JP2012136442A - Skin bactericidal detergent composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin bactericidal detergent composition which can exhibit high bactericidal properties in a sufficient degree even in use for a short period of time in consideration of a real hand-washing time at a busy site.SOLUTION: The skin bactericidal detergent composition comprises an (a) component: triclosan and/or parachlorometaxylenol of 0.05 to 2 mass%, a (b) component: alcohol represented by general formula (1): R-OH (wherein, Rdenotes a 6 to 10C hydrocarbon group), and a (c) component: an anionic surfactant of >2 to 35 mass%, and in which the mass ratio of the (c) component to the (b) component, (c)/(b)=0.9/1 to 15/1, and also, the pH of the composition at 25°C is <5.5.

Description

  The present invention relates to a skin sterilizing and cleaning composition that exhibits a high bactericidal effect even when used for a short time.

  In recent years, hand washing has been promoted in hospitals, nursing homes, food processing sites, kitchens, and the like for the purpose of preventing pathogenic bacteria from being transmitted and transmitted through fingers. In such a field, various skin sterilization detergent compositions are used in order to more reliably sterilize and clean the skin. For example, there are compositions containing a disinfectant in skin (finger) disinfectant and a composition containing a high disinfectant solvent such as ethanol.

  In Patent Document 1, a high bactericidal effect is obtained by the combined use of a specific anionic surfactant and triclosan, isopropylphenol and / or parachloroxylenol, and by containing glyceryl ether as a third component, foamability and low temperature stability are obtained. A liquid sterilizing detergent composition having excellent properties is proposed.

  Patent document 2 proposes to use a mixture containing glyceryl ether at a temperature of 25 ° C. or higher in order to sterilize the surface of the article.

JP 2008-138027 A JP 2004-315537 A

  In the above field, workers are often busy, and it is not practical to spend a long time washing hands.

  In order to reliably sterilize and clean the skin in a short time, for example, there is a method of increasing the content of various active ingredients. However, when the content of the active ingredient is increased, the stability of the composition particularly at low temperature storage tends to decrease. Since low-temperature storage is usually performed in the distribution process, if the stability of the composition is reduced, for example, when precipitation or separation of crystals occurs, the desired effect may not be exhibited during use.

  Accordingly, an object of the present invention is to provide a skin sterilizing and cleaning composition capable of exhibiting a sufficiently high degree of bactericidal properties even when used for a short time in consideration of the actual hand washing time in a busy site. It is.

  Therefore, as a result of studying various elements relating to the skin sterilizing detergent composition, the present inventors have found that by incorporating a specific component, sufficient bactericidal properties can be exhibited in a surprisingly short time, The present invention has been completed.

That is, the gist of the present invention is as follows.
(A) component: 0.05-2 mass% of triclosan and / or parachlorometaxylenol,
(B) Component: The following general formula (1)
R ¹ —OH (1)
(Wherein R ¹ is a hydrocarbon group having 6 to 10 carbon atoms), and (c) component: skin containing anionic surfactant more than 2 mass% and 35 mass% or less A sterilizing detergent composition comprising:
The mass ratio of the component (c) to the component (b) is (c) / (b) = 0.9 / 1 to 15/1, and the pH of the composition is less than 5.5. The present invention relates to a skin sterilizing and cleaning composition.

  The skin sterilizing detergent composition of the present invention has an excellent effect of having a detergency effect and exhibiting a high bactericidal property even when used for a short time. As a use form of the product of the present invention, it is possible to use the composition as a skin sterilization cleansing composition without diluting it, or to dilute it.

<(A) component>
The component (a) used in the present invention is triclosan and / or parachlorometaxylenol. The content of the component (a) in the skin sterilizing and cleaning composition of the present invention is 0.05 to 2% by mass, preferably 0.3 to 1.2% by mass. From the viewpoint of sufficiently exerting the bactericidal effect, the content is preferably 0.05% by mass or more, and from the viewpoint of ensuring the stability of the composition, the content is preferably 2% by mass or less.

  As the component (a), triclosan or parachlorometaxylenol can be used alone, but both can be used in combination.

  Moreover, it is more preferable to use (a) component and isopropylphenol together from the viewpoint of raw material odor. In this case, total (a) component / isopropylphenol = 5/1 to 1/3 (mass ratio) is preferable, 4/1 to 1/3 (mass ratio) is more preferable, and 3/1 to 1/2 (mass ratio). Ratio) is more preferable. Furthermore, it is more preferable to use triclosan and isopropylphenol in combination. In this case, triclosan / isopropylphenol = 5/1 to 1/3 (mass ratio) is preferable, 4/1 to 1/3 (mass ratio) is more preferable, and 3/1 to 1/2 (mass ratio) is further. preferable.

<(B) component>
The component (b) used in the present invention has the following general formula (1):
R ¹ —OH (1)
(Wherein R ¹ is a hydrocarbon group having 6 to 10 carbon atoms). The alcohol as the component (b) may be a primary alcohol or a secondary alcohol depending on the type of R ¹ .

Examples of the hydrocarbon group for R ¹ include a linear or branched alkyl group or alkenyl group. Examples of the alkyl group include an n-heptyl group, an n-octyl group, a 2-ethylhexyl group, an n-nonyl group, an n-decyl group, and an isodecyl group, and preferably an alkyl group having 8 to 10 carbon atoms. Specifically, an n-octyl group, 2-ethylhexyl group, n-nonyl group, n-decyl group, and isodecyl group can be mentioned. Examples of the alkenyl group include an octene group.

  Specific examples of the component (b) include 1-heptanol, 2-ethylhexanol, 1-octanol, 2-octanol, 1-decanol, 1-octen-3-ol, and citronellol. As the component (b), one type may be used alone, or two or more types may be used in combination.

  By blending such a component (b) into the skin sterilizing detergent composition, the effect of further exerting the sterilizing effect against bacteria such as Escherichia coli without reducing the cleaning effect of the detergent composition against oily and dirt. Is played.

  0.2-23 mass% is preferable, as for content of (b) component in a skin disinfection cleaning composition, 1-21 mass% is more preferable, and 1.2-20 mass% is further more preferable. From the viewpoint of further exerting a bactericidal effect against bacteria such as Escherichia coli without reducing the cleaning effect on fat and oil stains, the content is preferably 0.2% by mass or more, from the viewpoint of ensuring quality uniformity as a product. The content is preferably 23% by mass or less.

<(C) component>
The component (c) in the skin sterilizing and cleaning composition of the present invention is an anionic surfactant.

  The anionic surfactant used in the present invention is not particularly limited, but is alkyl or alkenyl sulfate, polyoxyalkylene alkyl or alkenyl ether sulfate, α-olefin sulfonate, alkyl benzene sulfonate, α-sulfo fatty acid. Examples thereof include salts or ester salts, alkyl or alkenyl ether carboxylates, and the like. As the component (c), one type of these compounds may be used alone, or a plurality of types may be used in combination.

Of these anionic surfactants, the following general formula (2):
R ² —O— (CH ₂ CH ₂ O) _m —SO ₃ M (2)
(In the formula, R ² is a hydrocarbon group having 8 to 16 carbon atoms, preferably a saturated or unsaturated aliphatic group having 8 to 16 carbon atoms, m represents the average number of added moles, and m = 0 to 3). And M is an ammonium ion, an alkali metal ion, an alkaline earth metal ion, or an alkanol ammonium ion). The number of carbon atoms of R ^2, preferably 10 to 16. As the average added mole number m, 0-3 are used, but 0-1 are preferable from the viewpoint of sterilization performance. Further, the counter ion represented by M is an ammonium ion, an alkali metal ion, an alkaline earth metal ion, or an alkanol ammonium ion, and specifically, an ammonium ion, a sodium ion, a potassium ion, a lithium ion, or calcium. Ions, triethanolammonium ions, diethanolammonium ions, and monoethanolammonium ions. Ammonium ions are preferred from the viewpoint of sterilization performance.

  Specific examples of the anionic surfactant include triethanolamine alkyl sulfate, ammonium alkyl sulfate, sodium alkyl sulfate, polyoxyethylene (1) alkyl ether triethanolamine, polyoxyethylene (1) alkyl ether ammonium sulfate, polyoxy Examples include ethylene (2) alkyl ether ammonium sulfate, polyoxyethylene (2) sodium alkyl ether sulfate and the like, and polyoxyethylene (1) alkyl ether sulfate triethanolamine and polyoxy from the viewpoint of foaming, bactericidal performance and skin irritation. Ethylene (1) alkyl ether ammonium sulfate is preferred. In addition, in this specification, the numerical value in the parenthesis of these compounds means the average added mole number of ethylene oxide.

  The content of the component (c) in the skin sterilizing and cleaning composition of the present invention exceeds 2% by mass and is 35% by mass or less, preferably 3 to 32% by mass, and more preferably 3 to 25% by mass. From the viewpoint of sufficiently exhibiting foamability and detergency, the content is preferably more than 2% by mass, and from the viewpoint of sufficiently exhibiting the bactericidal effect of the component (a), the content is 35% by mass. The following is preferred.

  The mass ratio of the component (c) to the component (b) is (c) / (b) = 0.9 / 1 to 15/1, preferably 1/1 to 12/1, 10/1 is more preferable. The mass ratio is preferably 0.9 / 1 or more from the viewpoint of the cleaning effect on fat and oil stains, and the mass ratio is preferably 15/1 or less from the viewpoint of exerting a bactericidal effect against bacteria such as Escherichia coli.

  The mass ratio of the component (c) and the component (a) is preferably (c) / (a) = 100/10 to 1000/5, and preferably 100/10 to 100/2, from the viewpoint of sufficiently exerting the bactericidal effect. Is more preferable.

<Skin disinfectant cleaning composition>
The skin sterilizing and cleaning composition of the present invention is preferably in a liquid state using water as a medium. The amount of water is not particularly limited, and can be appropriately set according to the amount of each component.

  The pH at 25 ° C. of the skin sterilizing and cleaning composition of the present invention is less than 5.5. pH can be calculated | required by measuring the undiluted | stock solution (25 degreeC) of the skin disinfection cleaning composition of this invention. Many conventional skin sterilizing and cleaning compositions have a neutral pH range (for example, 6 to 8) from the viewpoint of suppressing irritation to the skin. By reducing it to less than 5, the sterilization performance of the composition is further improved. By making the skin sterilization detergent composition acidic, adverse effects on the skin (irritation, hand feeling, etc.) may occur, but since the skin sterilization detergent composition of the present invention is excellent in sterilization performance, By using the composition of the present invention for a short time, sufficient sterilization performance can be exhibited, and as a result, such adverse effects can be greatly relieved.

  The pH of the skin sterilizing detergent composition (25 ° C.) of the present invention is preferably 3.0 or more and less than 5.5 from the viewpoint of achieving both improvement of bactericidal properties and low irritation to the skin, and 3.5 to 5. 2 is more preferable. . Less than 5.5 is preferable from the viewpoint of bactericidal properties, and 3.0 or more is preferable from the viewpoint of irritation.

  Although the details of the mechanism by which the pH of the skin sterilizing and cleaning composition (25 ° C.) of the present invention is less than 5.5 can ensure higher bactericidal properties even when used for a short time, the details are not clear. When the fungicide component is adsorbed to the cell surface by the component (b) in the system and acts, it is assumed that the pH has some influence on the penetration of the fungicide into the cell.

  Examples of the pH adjuster used for adjusting the pH of the skin sterilizing and cleaning composition of the present invention to a desired range include pH adjusters known in the technical field of the present invention, but citric acid, malic acid, Hydroxy acids such as tartaric acid are preferred.

<(D) component>
In the present invention, the component (d) preferably further contains at least one compound selected from the group consisting of benzoate, sorbate, propionate, salicylate and dehydroacetate. It is more preferable to contain an acid salt. (D) As content of a component, 0.01-2.5 mass% of the skin disinfection cleaning composition of this invention is preferable, 0.05-1.75 mass% is more preferable, 0.1-1 More preferred is mass%. From the viewpoint of sufficiently exhibiting the bactericidal effect, the content is preferably 0.01% by mass or more, and from the viewpoint of ensuring the stability of the composition, the content is preferably 2.5% by mass or less. As the salt, alkali metal salts such as sodium salt and potassium salt are preferable. As the compound of component (d), one type may be used alone, or two or more types may be used in combination.

  (D) Although the mechanism about the point which the disinfection performance of the skin disinfection cleaning composition of this invention improves further by including a component is not clear, (D), so that pH of the composition of this invention becomes lower. It is considered that the proportion of non-dissociable molecules increases in the component, and when the pH of the composition of the present invention (25 ° C.) becomes less than 5.5, the non-dissociable molecule is converted into component (a), It is estimated that it contributes to the sterilization performance by the component (b) and / or the component (c).

  Furthermore, the skin sterilizing detergent composition of the present invention is a component used in ordinary skin sterilizing detergent compositions, for example, lower alcohols such as ethanol; plant-derived polysaccharides such as guar gum; microorganism-derived polysaccharides such as xanthan gum. Celluloses such as hydroxypropylcellulose and carboxymethylcellulose; colorants such as dyes and pigments; inorganic salts such as sodium chloride and sodium sulfate; plant extracts; preservatives; chelating agents such as EDTA; vitamins; Anti-inflammatory agents such as dipotassium; antioxidants such as BHT; humectants such as ceramide analogs such as natural ceramide and synthetic ceramide, etc. may be contained within a range not impairing the effects of the present invention.

  The skin sterilizing and cleaning composition of the present invention can be used by filling it into a container that is usually used. However, by filling it into a former container, it has good foaming properties and good foam stability. Therefore, it is more preferable to fill the former container. The above shows the conditions when using the stock solution. In the case of dilution use, it is more preferable to fill the former container with the diluent.

  The skin sterilizing and cleaning composition of the present invention can be produced according to a conventional method. For example, after the component (a) is dissolved in the component (b), the component (c), water, the component (d), etc. are added, and the pH of the skin disinfectant cleaning composition (25 ° C.) is 5 with a pH adjuster. Can be manufactured to be less than .5. As for the blending amount of each component, the description of the content of each component described above can be applied as it is as the description of the blending amount.

  Furthermore, the skin sterilization cleaning composition of the present invention is preferably used as a liquid sterilization cleaning agent for the body, for example, a hand cleaning agent such as a hand soap, a body shampoo, and a hair shampoo. It is more preferable to be used as a cleaning agent, and as an application site, it is further preferable to be used for a hospital, a nursing facility, or a kitchen.

  Hereinafter, an example is given and it demonstrates in detail. In addition, content of each component in a following example etc. was shown by the mass% in Table 1 and Table 2 on the basis of the effective part. In addition, about the numerical value of the component ratio (c component / b component) in a table | surface, the denominator (/ 1) was abbreviate | omitted and described.

The components (b) and non- (b) in each table are as follows.
b-1: 1-heptanol b-2: 1-octanol b-3: 2-octanol b-4: 2-ethylhexanol b-5: 1-decanol b′-1: 1-butanol b′-2: myristyl alcohol

(C) component in each table | surface is as follows.
1: ammonium lauryl sulfate 2: triethanolamine lauryl sulfate 3: polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆ ) ether ammonium sulfate 4: coconut oil fatty acid acylglycine potassium (Ajinomoto Healthy Supply Co., Ltd., Amlite GCK-12K (30%))
5: Lauroyl sarcosine sodium (manufactured by Kawaken Fine Chemical Co., Ltd., Soypon SLE (30%))
6: Palm oil fatty acid methyl taurine sodium (Nikko Chemicals, NIKKOL CMT-30 (30%))

(Test method and evaluation criteria for bactericidal effect)
As test bacteria, Escherichia coli NBRC3972 and Staphylococcus aureus NBRC13276 were used. A culture solution pre-cultured in an SCD medium [manufactured by Nippon Pharmaceutical Co., Ltd.] was prepared in advance. Culture 0.1mL of ^{(10 9 ~10 10 cell / mL} ), a predetermined concentration with sterile water (compositions dilution × 3, × 10, × 40 ) in a dilute solution of the composition of 2mL diluted in Vaccinated. Every fixed time (15 seconds, 30 seconds), one platinum loop was taken from each diluted solution and inoculated into 1 mL of a growth medium (SCDLP medium [manufactured by Nippon Pharmaceutical Co., Ltd.]). After the growth liquid medium was cultured at 37 ° C. for 24 hours, the presence or absence of growth of the bacteria was observed.

  The presence or absence of fungal growth was determined visually. That is, when turbidity was observed in the cultured medium, it was determined that the bacteria had grown. Since one type of skin sterilizing detergent composition was tested for sterilizing effect at three dilution concentrations and two contact times, visual judgment was performed on a total of six growth media. The determination of the bactericidal effect was performed as follows according to the number of growth media in which the growth of bacteria was not observed. When no growth of bacteria was observed (that is, no growth of bacteria was observed for all 6 growth media), the highest score (full score) was 6, and the total dilution concentration and total reaction time were The case where the growth of bacteria was observed in all of the growth media was set to 0 as the lowest score. That is, it means that the higher the value between 0 and 6, the higher the bactericidal effect of the skin sterilizing detergent composition. About a result, the test was done 3 times about one sample and the average value of the obtained value was shown as sterilization performance.

(Cleaning effect test method and evaluation criteria)
Samples 1 and 2 below were used as a model for oily and dirt stains.
0.5 mL of the oil / fat sample of Sample 1 was taken and applied uniformly to the palm. Hands were washed with 1 mL of each composition (washing and rinsing for 15 seconds each, water temperature of about 30 ° C., tap water, constant amount of water). Subsequently, Sample 2 was also evaluated in the same manner.

Sample 1: Squalane (deep sea bream liver extract oil), reagent, [manufactured by Tokyo Chemical Industry Co., Ltd.]
Sample 2: Cottonseed oil, reagent, [manufactured by Kanto Chemical Co., Ltd.]

  The cleaning effect was evaluated by five panelists. The panelists were instructed to perform the hand washing operation in the same manner for all the compositions, and did not inform which of the compositions was the product of the present invention and which was a comparative product. The case where fat and oil stains were completely removed was set to 5, and the case where no oily stains were removed was set to 1, and the cleaning effect was sensory evaluated with an integer between 1 and 5. It means that the higher the value, the higher the cleaning effect of the composition against oil stains. The numerical value was determined by the average value of Sample 1 and Sample 2.

Example 1 and Comparative Example 1
Compositions having the compositions shown in Tables 1 and 2 were prepared according to a conventional method, and a bactericidal effect test and a cleaning effect test were conducted. The results are shown in Tables 1 and 2. The cleaning effect of the product of the present invention and the comparative product are all in the range of 4 to 5 except that the evaluation value of the comparative product 7 is 2, and it was shown that these compositions exhibit an excellent cleaning effect. .

  Thus, it was found that the product of the present invention effectively killed Escherichia coli and Staphylococcus aureus by contact for an extremely short time (for example, within 15 seconds) assuming actual hand washing.

On the other hand, when a comparative product was examined, when any of the component (a) and the component (b) was not contained, the bactericidal effect against Escherichia coli was not sufficient (Comparative products 1 and 2). The bactericidal effect was remarkably reduced when the number of carbon atoms of R ¹ of the component (b) was small and large (Comparative products 3, 4 and 8). When the amount of the component (c) was less than the prescribed amount, a tendency of low bactericidal effect against E. coli was observed (Comparative Product 7). Furthermore, when the mass ratio of (c) / (b) exceeded 15/1 or when the pH of the composition was 5.5 or more, the bactericidal effect on Escherichia coli was not particularly sufficient (Comparative products 5 and 6). ).

Example 2 (hand soap)
A hand soap having the following composition was produced by a conventional method. The pH of the resulting hand soap solution (25 ° C.) was 5.0, which was excellent in cleanability and high sterilization effect. In addition, five panelists replied that they did not experience irritation or touch when they cleaned their fingers for normal use over two weeks.

Polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆₎ ether sulfate: 5.0 (wt%)
・ 2-ethylhexanol: 2.5 (mass%)
・ Triclosan: 0.3 (mass%)
・ Isopropylmethylphenol: 0.1 (mass%)
・ Glycerin: 10.0 (mass%)
-PH adjuster (citric acid): appropriate amount (amount that makes hand soap pH 5.0)
・ Purified water: Balance ・ Total: 100 (mass%)

  The skin sterilizing and cleaning composition of the present invention has a high sterilizing effect in a short use time without increasing the amount of the sterilizing agent, and is therefore suitable for use in hospitals, nursing homes, food processing sites, kitchens and other sites. Applicable to.

Claims (2)

(A) component: 0.05-2 mass% of triclosan and / or parachlorometaxylenol,
(B) Component: The following general formula (1)
R ¹ —OH (1)
(Wherein R ¹ is a hydrocarbon group having 6 to 10 carbon atoms), and (c) component: skin containing anionic surfactant more than 2 mass% and 35 mass% or less A sterilizing detergent composition comprising:
The mass ratio of the component (c) to the component (b) is (c) / (b) = 0.9 / 1 to 15/1, and the pH of the composition is less than 5.5. Skin disinfectant cleaning composition.   The composition according to claim 1, which is used for hand soap, body shampoo or hair shampoo.