JP6704099B1 - Sterilizing or virus inactivating agent composition, and method for enhancing efficacy of sterilizing or virus inactivating agent - Google Patents
Sterilizing or virus inactivating agent composition, and method for enhancing efficacy of sterilizing or virus inactivating agent Download PDFInfo
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- JP6704099B1 JP6704099B1 JP2020506286A JP2020506286A JP6704099B1 JP 6704099 B1 JP6704099 B1 JP 6704099B1 JP 2020506286 A JP2020506286 A JP 2020506286A JP 2020506286 A JP2020506286 A JP 2020506286A JP 6704099 B1 JP6704099 B1 JP 6704099B1
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- Prior art keywords
- virus inactivating
- virus
- sodium
- seed extract
- bactericidal
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- 241000700605 Viruses Species 0.000 title claims abstract description 189
- 230000000415 inactivating effect Effects 0.000 title claims abstract description 162
- 239000000203 mixture Substances 0.000 title claims abstract description 107
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 71
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims description 29
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 111
- 229940107702 grapefruit seed extract Drugs 0.000 claims abstract description 92
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 72
- 238000002156 mixing Methods 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract description 14
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 14
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940049920 malate Drugs 0.000 claims abstract description 14
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 claims abstract description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 13
- GRSZFWQUAKGDAV-KQYNXXCUSA-L IMP(2-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(N=CNC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-L 0.000 claims abstract description 13
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 claims abstract description 13
- 229940075554 sorbate Drugs 0.000 claims abstract description 13
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims abstract description 13
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 11
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000010452 phosphate Substances 0.000 claims abstract description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 72
- -1 sorbates Chemical class 0.000 claims description 51
- 238000004659 sterilization and disinfection Methods 0.000 claims description 50
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 36
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 36
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 28
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 25
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 19
- 239000004302 potassium sorbate Substances 0.000 claims description 19
- 235000010241 potassium sorbate Nutrition 0.000 claims description 19
- 229940069338 potassium sorbate Drugs 0.000 claims description 19
- 239000001509 sodium citrate Substances 0.000 claims description 16
- AANLCWYVVNBGEE-IDIVVRGQSA-L Disodium inosinate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 AANLCWYVVNBGEE-IDIVVRGQSA-L 0.000 claims description 14
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 14
- 239000004194 disodium inosinate Substances 0.000 claims description 14
- 235000013890 disodium inosinate Nutrition 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 14
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims description 14
- 235000010265 sodium sulphite Nutrition 0.000 claims description 14
- 230000002779 inactivation Effects 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 235000021317 phosphate Nutrition 0.000 claims description 12
- 239000001508 potassium citrate Substances 0.000 claims description 12
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 12
- 235000015870 tripotassium citrate Nutrition 0.000 claims description 12
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical group [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 12
- 229940038773 trisodium citrate Drugs 0.000 claims description 12
- 235000019263 trisodium citrate Nutrition 0.000 claims description 12
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 11
- 238000013329 compounding Methods 0.000 claims description 11
- 230000000855 fungicidal effect Effects 0.000 claims description 11
- 239000001632 sodium acetate Substances 0.000 claims description 11
- 235000017281 sodium acetate Nutrition 0.000 claims description 11
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 11
- 239000004299 sodium benzoate Substances 0.000 claims description 11
- 235000010234 sodium benzoate Nutrition 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 239000003899 bactericide agent Substances 0.000 claims description 8
- 244000309711 non-enveloped viruses Species 0.000 claims description 8
- 239000000417 fungicide Substances 0.000 claims description 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 235000017550 sodium carbonate Nutrition 0.000 claims description 4
- 235000011083 sodium citrates Nutrition 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 240000000560 Citrus x paradisi Species 0.000 claims description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 3
- 230000002070 germicidal effect Effects 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 2
- 230000000937 inactivator Effects 0.000 claims description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
- 230000003014 reinforcing effect Effects 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 34
- 235000002639 sodium chloride Nutrition 0.000 description 32
- 230000000052 comparative effect Effects 0.000 description 15
- PJAHUDTUZRZBKM-UHFFFAOYSA-K potassium citrate monohydrate Chemical compound O.[K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PJAHUDTUZRZBKM-UHFFFAOYSA-K 0.000 description 14
- 241000894006 Bacteria Species 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- MQRJBSHKWOFOGF-UHFFFAOYSA-L disodium;carbonate;hydrate Chemical compound O.[Na+].[Na+].[O-]C([O-])=O MQRJBSHKWOFOGF-UHFFFAOYSA-L 0.000 description 8
- 239000004332 silver Substances 0.000 description 8
- 229910052709 silver Inorganic materials 0.000 description 8
- 229940076133 sodium carbonate monohydrate Drugs 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000012085 test solution Substances 0.000 description 8
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 7
- 241000714201 Feline calicivirus Species 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 239000003242 anti bacterial agent Substances 0.000 description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 241001263478 Norovirus Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 150000001734 carboxylic acid salts Chemical class 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 5
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 5
- 150000007524 organic acids Chemical group 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 4
- 230000010261 cell growth Effects 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
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- 241000951471 Citrus junos Species 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 2
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 2
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- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 231100000645 Reed–Muench method Toxicity 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 239000004855 amber Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical compound OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 description 1
- 229940005991 chloric acid Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- IERHLVCPSMICTF-XVFCMESISA-N cytidine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IERHLVCPSMICTF-XVFCMESISA-N 0.000 description 1
- GYOZYWVXFNDGLU-XLPZGREQSA-N dTMP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 GYOZYWVXFNDGLU-XLPZGREQSA-N 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- QCPTVXCMROGZOL-UHFFFAOYSA-L dipotassium;oxalate;hydrate Chemical compound O.[K+].[K+].[O-]C(=O)C([O-])=O QCPTVXCMROGZOL-UHFFFAOYSA-L 0.000 description 1
- PVBRXXAAPNGWGE-LGVAUZIVSA-L disodium 5'-guanylate Chemical compound [Na+].[Na+].C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O PVBRXXAAPNGWGE-LGVAUZIVSA-L 0.000 description 1
- 235000013896 disodium guanylate Nutrition 0.000 description 1
- 239000004198 disodium guanylate Substances 0.000 description 1
- MSJMDZAOKORVFC-UAIGNFCESA-L disodium maleate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C/C([O-])=O MSJMDZAOKORVFC-UAIGNFCESA-L 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical class OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-M hexanoate Chemical compound CCCCCC([O-])=O FUZZWVXGSFPDMH-UHFFFAOYSA-M 0.000 description 1
- 239000008235 industrial water Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 235000013902 inosinic acid Nutrition 0.000 description 1
- 239000004245 inosinic acid Substances 0.000 description 1
- 229940028843 inosinic acid Drugs 0.000 description 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical class OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 150000004701 malic acid derivatives Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 235000014786 phosphorus Nutrition 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- IWZKICVEHNUQTL-UHFFFAOYSA-M potassium hydrogen phthalate Chemical compound [K+].OC(=O)C1=CC=CC=C1C([O-])=O IWZKICVEHNUQTL-UHFFFAOYSA-M 0.000 description 1
- BLGUIMKBRCQORR-UHFFFAOYSA-M potassium;hexanoate Chemical compound [K+].CCCCCC([O-])=O BLGUIMKBRCQORR-UHFFFAOYSA-M 0.000 description 1
- VZOPRCCTKLAGPN-ZFJVMAEJSA-L potassium;sodium;(2r,3r)-2,3-dihydroxybutanedioate;tetrahydrate Chemical compound O.O.O.O.[Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VZOPRCCTKLAGPN-ZFJVMAEJSA-L 0.000 description 1
- VZOPRCCTKLAGPN-UHFFFAOYSA-L potassium;sodium;2,3-dihydroxybutanedioate;tetrahydrate Chemical compound O.O.O.O.[Na+].[K+].[O-]C(=O)C(O)C(O)C([O-])=O VZOPRCCTKLAGPN-UHFFFAOYSA-L 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- KYKFCSHPTAVNJD-UHFFFAOYSA-L sodium adipate Chemical compound [Na+].[Na+].[O-]C(=O)CCCCC([O-])=O KYKFCSHPTAVNJD-UHFFFAOYSA-L 0.000 description 1
- 235000011049 sodium adipate Nutrition 0.000 description 1
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- PRWXGRGLHYDWPS-UHFFFAOYSA-L sodium malonate Chemical compound [Na+].[Na+].[O-]C(=O)CC([O-])=O PRWXGRGLHYDWPS-UHFFFAOYSA-L 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940074446 sodium potassium tartrate tetrahydrate Drugs 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- LHYPLJGBYPAQAK-UHFFFAOYSA-M sodium;pentanoate Chemical compound [Na+].CCCCC([O-])=O LHYPLJGBYPAQAK-UHFFFAOYSA-M 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N59/26—Phosphorus; Compounds thereof
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
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Abstract
（Ａ）殺菌またはウイルス不活性化成分としてグレープフルーツ種子抽出物と、（Ｂ）殺菌またはウイルス不活性化効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上と、を水に混合してなる殺菌またはウイルス不活性化剤組成物。(A) Grapefruit seed extract as a bactericidal or virus inactivating component, and (B) citrate, benzoate, malate, inosinate, guanylate as a bactericidal or virus inactivating potency enhancing component, A sterilizing or virus inactivating agent composition which is obtained by mixing water with one or more selected from acetate, succinate, sorbate, carbonate, sulfite, and phosphate.
Description
本発明は、殺菌、ウイルス不活性化成分を水溶液中に配合して成る殺菌、ウイルス不活性化剤組成物、および殺菌、ウイルス不活性化剤組成物の殺菌、ウイルス不活性化効力増強方法に関する。 TECHNICAL FIELD The present invention relates to sterilization, sterilization in which a virus inactivating component is mixed in an aqueous solution, a virus inactivating agent composition, and sterilization, sterilization of virus inactivating agent composition, and method for enhancing virus inactivating effect. .
浴室・トイレ、キッチン等のタイル、目地、プラスチックに付着する汚れの中には、細菌やカビによって発生する汚れやぬめりなどがある。このような細菌やカビによる汚れは、次亜塩素酸塩を主成分とする液体洗浄剤などで、日常的に殺菌を行うことで、発生を予防することができる。しかし、次亜塩素酸製剤は、酸性タイプの漂白剤等と混用すると危険な塩素ガスを発生することから、本来的には使用を制限すべき製品であるが、他に置き換える製品が存在しないため現在でも広く使用されている。こうした現状から、安全性が高く、且つ殺菌効果の高い洗浄剤が要望されている。 Among the stains that adhere to tiles, joints, and plastics in bathrooms, toilets, kitchens, etc., there are stains and slime generated by bacteria and mold. Such stains caused by bacteria and mold can be prevented by routinely sterilizing with a liquid detergent containing hypochlorite as a main component. However, hypochlorous acid formulations generate dangerous chlorine gas when mixed with acid type bleaching agents, so their use should be restricted, but there is no other product to replace them. It is still widely used today. Under these circumstances, a cleaning agent having high safety and a high bactericidal effect has been demanded.
このような細菌を除菌、殺菌するために、殺菌成分としてエタノールを配合したスプレータイプの殺菌剤が広く用いられている。しかし、エタノールは引火性を有するため、キッチン周り等の火を使う場所での使用には注意が必要であった。また、エタノールを含む殺菌剤を樹脂製部材に塗布した際に塗装やワックスの剥がれが発生するおそれもあり、エタノールの匂いが苦手な人やエタノールで手が荒れる人には使用し難いという問題点もあった。さらに、キッチン周りには食品や食器等が存在するため、それらに付着しても健康に影響のない安全性の高い殺菌剤が要望されていた。 In order to sterilize and sterilize such bacteria, spray-type bactericides containing ethanol as a bactericidal component are widely used. However, since ethanol is flammable, it was necessary to be careful when using it in a place where fire is used, such as around the kitchen. Further, when a sterilizing agent containing ethanol is applied to a resin member, there is a risk that coating or wax peeling may occur, and it is difficult to use for people who are not good at smelling ethanol or who have rough hands with ethanol. There was also. Further, since food and tableware are present around the kitchen, there is a demand for a highly safe bactericide that does not affect health even if it adheres to them.
そこで、食品添加物として使用される安全性の高い殺菌成分を配合した、アルコールの配合量を低減させた殺菌剤が種々提案されている。例えば、特許文献１には、（Ａ）成分としてエタノール、（Ｂ）成分として有機酸及び／又は有機酸塩、（Ｃ）成分としてグリセリン脂肪酸エステル、（Ｄ）グレープフルーツ種子抽出物、及び（Ｅ）水を含有し、ｐＨが２５℃で２．５以上、６．０以下である、アルコール製剤が開示されている。 Therefore, various bactericides containing a highly safe bactericidal component used as a food additive and having a reduced alcohol content have been proposed. For example, Patent Document 1 discloses that (A) component is ethanol, (B) component is an organic acid and/or organic acid salt, (C) component is glycerin fatty acid ester, (D) grapefruit seed extract, and (E). Disclosed is an alcohol preparation which contains water and has a pH of 2.5 or more and 6.0 or less at 25°C.
また、特許文献２には、強アルカリ電解水と柑橘類の種子から抽出した成分を含む洗浄ならびに除菌用組成物が開示されており、抽出成分としてグレープフルーツ種子抽出物を用いることも記載されている。 Further, Patent Document 2 discloses a composition for cleaning and disinfecting containing components extracted from strongly alkaline electrolyzed water and citrus seeds, and also describes using a grapefruit seed extract as an extraction component. ..
特許文献１、２に記載されているグレープフルーツ種子抽出物は、天然由来の除菌成分であり、それ自体が殺菌、抗菌活性を有することが知られている。また、グレープフルーツ種子抽出物は水溶性であるとともに、特有の匂いもないため、殺菌、抗菌成分として水系製剤に配合し易いという利点を有する。 The grapefruit seed extract described in Patent Documents 1 and 2 is a naturally derived sterilizing component, and is known to have bactericidal and antibacterial activity itself. Further, since the grapefruit seed extract is water-soluble and has no peculiar odor, it has an advantage that it can be easily incorporated into a water-based preparation as a sterilizing and antibacterial component.
また、食品製造及び調理施設、医療施設、教育施設等においてカリシウイルス科のノロウイルスによる食中毒が問題となっている。ノロウイルスの不活性化の方法としては、次亜塩素酸ナトリウム溶液を用いる方法や、熱湯消毒による方法が知られている。しかし、次亜塩素酸による消毒では処理面を漂白したり、悪臭が発生したりするなど使い勝手が悪く、酸性タイプの漂白剤等と混用すると塩素ガスを発生するため安全性の面で十分ではなかった。また、熱湯消毒では、被消毒物との接触によって温度が低下してしまい所望の温度を保持することが困難である。さらに、熱湯によるやけどの危険もある。 Further, food poisoning due to norovirus of Caliciviridae has become a problem in food manufacturing and cooking facilities, medical facilities, educational facilities, and the like. As a method for inactivating the norovirus, a method using a sodium hypochlorite solution and a method using hot water disinfection are known. However, disinfection with hypochlorous acid is not easy to use, such as bleaching the treated surface or generating a bad odor, and chlorine gas is generated when mixed with an acid type bleaching agent, so it is not sufficient in terms of safety. It was Further, in hot water sterilization, it is difficult to maintain a desired temperature because the temperature lowers due to contact with the object to be sterilized. There is also the risk of burns from hot water.
特許文献３には、少なくとも１種以上のビス四級アンモニウム化合物、ならびに銀系抗菌剤を含有するウイルス不活性化剤が開示されている。 Patent Document 3 discloses a virus inactivating agent containing at least one bis-quaternary ammonium compound and a silver-based antibacterial agent.
しかしながら、特許文献１のアルコール製剤は、エタノールを含有するため引火性やエタノールによる刺激性の問題があった。また、ｐＨが２．５以上６．０以下と酸性であるため、酸による刺激性の問題もあった。特許文献２の洗浄ならびに除菌用組成物は強アルカリ性であるため、アルカリによる刺激性の問題があった。 However, the alcohol preparation of Patent Document 1 has problems of flammability and irritation due to ethanol because it contains ethanol. In addition, since the pH is acidic at 2.5 or more and 6.0 or less, there is a problem of irritation due to acid. Since the composition for cleaning and disinfecting of Patent Document 2 is strongly alkaline, there is a problem of irritation due to alkali.
また、特許文献３のウイルス不活性化剤は、銀系抗菌剤を含有するため、銀イオンによる樹脂の変色、着色という問題点があった。 Further, since the virus inactivating agent of Patent Document 3 contains a silver-based antibacterial agent, there is a problem that the resin is discolored or colored by silver ions.
本発明は、上記問題点に鑑み、殺菌成分として次亜塩素酸やアルコールを含まず、ウイルス不活性化成分として銀系抗菌剤を含まない殺菌、ウイルス不活性化剤組成物、および殺菌、ウイルス不活性化効力増強方法を提供することを目的とする。 The present invention, in view of the above problems, does not contain hypochlorous acid or alcohol as a bactericidal component, sterilization not containing a silver-based antibacterial agent as a virus inactivating component, a virus inactivating agent composition, and sterilization, virus It is intended to provide a method for enhancing inactivation potency.
上記目的を達成するために本発明は、（Ａ）殺菌成分としてグレープフルーツ種子抽出物と、（Ｂ）殺菌効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上と、を水に混合してなる殺菌剤組成物（ただし、グレープフルーツ種子抽出物とベンジルアルコールと安息香酸ナトリウムとの組み合わせ、グレープフルーツ種子抽出物と酢酸ナトリウムとの組み合わせ、および／又はグレープフルーツ種子抽出物と澱粉加水分解物と、炭酸水素ナトリウム、クエン酸ナトリウム、ソルビン酸カリウム、リン酸一ナトリウムから選ばれた１種以上との組み合わせを除く）である。また本発明は、（Ａ）ウイルス不活性化成分としてグレープフルーツ種子抽出物と、（Ｂ）ウイルス不活性化効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上と、を水に混合してなるウイルス不活性化剤組成物である。 In order to achieve the above object, the present invention provides (A) a grapefruit seed extract as a bactericidal component , and (B) a citrate, benzoate, malate, inosinate, guanylate as a bactericidal effect enhancing component. , An acetate, a succinate, a sorbate, a carbonate, a sulfite and a phosphate, and one or more kinds selected from the mixture, and a bactericidal composition obtained by mixing it with water (however, grapefruit seed extraction And benzyl alcohol and sodium benzoate, grapefruit seed extract and sodium acetate, and/or grapefruit seed extract and starch hydrolyzate, sodium hydrogen carbonate, sodium citrate, potassium sorbate, phosphorus (Excluding combinations with one or more selected from monosodium acid) . The present invention also relates to (A) a grapefruit seed extract as a virus inactivating component, and (B) a citrate, benzoate, malate, inosinate, guanylate as a virus inactivating potency enhancing component. The virus inactivator composition is a mixture of water, and one or more selected from acetate, succinate, sorbate, carbonate, sulfite, and phosphate.
また本発明は、上記構成の殺菌またはウイルス不活性化剤組成物のｐＨが６〜１１であることを特徴としている。 Further, the present invention is characterized in that the sterilizing or virus inactivating agent composition having the above-mentioned constitution has a pH of 6 to 11.
また本発明は、上記構成の殺菌剤組成物において、前記殺菌効力増強成分が、クエン酸三ナトリウム、クエン酸三カリウム、イノシン酸二ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、炭酸水素ナトリウム、炭酸ナトリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムから選ばれた１種又は２種以上であることを特徴としている。 Further, the present invention, in the bactericidal composition having the above-mentioned constitution, the bactericidal effect enhancing component is trisodium citrate, tripotassium citrate, disodium inosinate, disodium succinate, potassium sorbate, sodium hydrogen carbonate, carbonic acid. One or two or more selected from sodium, sodium sulfite, and disodium hydrogen phosphate are featured.
また本発明は、上記構成の殺菌剤組成物において、前記グレープフルーツ種子抽出物の配合量が０．００５質量％以上であることを特徴としている。 Further, the present invention is characterized in that, in the bactericide composition having the above-mentioned constitution, the blending amount of the grapefruit seed extract is 0.005% by mass or more.
また本発明は、上記構成の殺菌剤組成物において、前記殺菌効力増強成分の配合量が０．０００５質量％以上であることを特徴としている。 Further, the present invention is characterized in that, in the bactericidal composition having the above constitution, the blending amount of the bactericidal efficacy enhancing component is 0.0005 mass% or more.
また本発明は、上記構成のウイルス不活性化剤組成物において、前記ウイルス不活性化効力増強成分が、クエン酸三ナトリウム、クエン酸三カリウム、炭酸水素ナトリウムから選ばれた１種又は２種以上であることを特徴としている。 The present invention also provides the virus inactivating agent composition having the above-mentioned constitution, wherein the virus inactivating potency enhancing component is one or more selected from trisodium citrate, tripotassium citrate, and sodium hydrogen carbonate. It is characterized by
また本発明は、上記構成のウイルス不活性化剤組成物において、前記グレープフルーツ種子抽出物の配合量が０．１質量％以上であることを特徴としている。 Further, the present invention is characterized in that, in the virus inactivating agent composition having the above-mentioned constitution, the compounding amount of the grapefruit seed extract is 0.1% by mass or more.
また本発明は、上記構成のウイルス不活性化剤組成物において、前記ウイルス不活性化効力増強成分の配合量が０．０１質量％以上であることを特徴としている。 Further, the present invention is characterized in that, in the virus inactivating agent composition having the above-mentioned constitution, the compounding amount of the virus inactivating potency enhancing component is 0.01% by mass or more.
また本発明は、（Ａ）殺菌成分としてグレープフルーツ種子抽出物と、（Ｃ）水と、を含有する殺菌剤組成物に、（Ｂ）殺菌効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上を添加することを特徴とする殺菌効力増強方法（ただし、グレープフルーツ種子抽出物とベンジルアルコールとを含む殺菌剤組成物に、安息香酸ナトリウムを添加する場合、グレープフルーツ種子抽出物を含む殺菌剤組成物に酢酸ナトリウムを添加する場合、および／又はグレープフルーツ種子抽出物と澱粉加水分解物とを含む殺菌剤組成物に、炭酸水素ナトリウム、クエン酸ナトリウム、ソルビン酸カリウム、リン酸一ナトリウムから選ばれた１種以上を添加する場合を除く）である。また本発明は、（Ａ）ウイルス不活性化成分としてグレープフルーツ種子抽出物と、（Ｃ）水と、を含有するウイルス不活性化剤組成物に、（Ｂ）ウイルス不活性化効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上を添加することを特徴とするウイルス不活性化効力増強方法である。 The present invention, (A) and grapefruit seed extract as bactericidal component, a fungicidal composition containing, and (C) water, (B) citrate as the germicidal effect reinforcing component, benzoate, malate Bactericidal efficacy characterized by adding one or more selected from salts, inosinates, guanylates, acetates, succinates, sorbates, carbonates, sulfites and phosphates Enhancement method (provided that sodium benzoate is added to a fungicide composition containing a grapefruit seed extract and benzyl alcohol, sodium acetate is added to a fungicide composition containing a grapefruit seed extract, and/or (Except when one or more selected from sodium hydrogen carbonate, sodium citrate, potassium sorbate, and monosodium phosphate is added to a fungicide composition containing a grapefruit seed extract and a starch hydrolyzate) . .. The present invention also provides a virus inactivating agent composition containing (A) a grapefruit seed extract as a virus inactivating component, and (C) water, and a (B) virus inactivating potency enhancing component as a quenching agent. Acid salt, benzoate, malate, inosinate, guanylate, acetate, succinate, sorbate, carbonate, sulfite, phosphate selected from one or more It is a method for enhancing the efficacy of virus inactivation, which is characterized in that it is added.
また本発明は、上記構成の殺菌効力増強方法において、前記殺菌効力増強成分が、クエン酸三ナトリウム、クエン酸三カリウム、イノシン酸二ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、炭酸水素ナトリウム、炭酸ナトリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムから選ばれた１種又は２種以上であることを特徴としている。 Further, the present invention, in the bactericidal efficacy enhancing method of the above configuration, the bactericidal efficacy enhancing component is trisodium citrate, tripotassium citrate, disodium inosinate, disodium succinate, potassium sorbate, sodium hydrogen carbonate, carbonic acid. One or two or more selected from sodium, sodium sulfite, and disodium hydrogen phosphate are featured.
また本発明は、上記構成の殺菌またはウイルス不活性化効力増強方法において、前記殺菌効力増強成分が、炭酸水素ナトリウムであることを特徴としている。 Further, the present invention is characterized in that, in the sterilizing or virus inactivating potency enhancing method having the above-mentioned constitution, the bactericidal potency enhancing component is sodium hydrogen carbonate.
また本発明は、上記構成の殺菌効力増強方法において、前記殺菌効力増強成分の添加量が、前記殺菌剤組成物に対して０．０００５質量％以上であることを特徴としている。 Further, the present invention is characterized in that, in the bactericidal efficacy enhancing method having the above-mentioned constitution, the amount of the bactericidal efficacy enhancing component added is 0.0005% by mass or more based on the bactericidal composition.
また本発明は、上記構成のウイルス不活性化効力増強方法において、前記ウイルス不活性化効力増強成分が、クエン酸三ナトリウム、クエン酸三カリウム、炭酸水素ナトリウムから選ばれた１種又は２種以上であることを特徴としている。 Further, the present invention provides the virus inactivating potency enhancing method having the above-mentioned constitution, wherein the virus inactivating potency enhancing component is one or more selected from trisodium citrate, tripotassium citrate and sodium hydrogen carbonate. It is characterized by
また本発明は、上記構成のウイルス不活性化効力増強方法において、前記ウイルス不活性化効力増強成分の添加量が、前記ウイルス不活性化剤組成物に対して０．０１質量％以上であることを特徴としている。 Further, in the present invention, in the virus inactivating potency enhancing method having the above constitution, the amount of the virus inactivating potency enhancing component added is 0.01% by mass or more based on the virus inactivating agent composition. Is characterized by.
また本発明は、上記構成のウイルス不活性化剤組成物をノンエンベロープウイルスに対して接触させるノンエンベロープウイルスの不活性化方法である。 The present invention also provides a method for inactivating a non-enveloped virus, which comprises contacting the non-enveloped virus with the virus inactivating agent composition having the above structure.
本発明の第１の構成によれば、（Ａ）殺菌成分としてグレープフルーツ種子抽出物と、（Ｂ）殺菌効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上と、を水に混合することにより、また、本発明の第２の構成によれば、（Ａ）ウイルス不活性化成分としてグレープフルーツ種子抽出物と、（Ｂ）ウイルス不活性化効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上と、を水に混合することにより、殺菌またはウイルス不活性化成分として次亜塩素酸やアルコールを含まず低刺激性であり、且つ高い殺菌またはウイルス不活性化効力を備えた殺菌またはウイルス不活性化剤組成物となる。 According to the first aspect of the present invention, (A) a grapefruit seed extract as a bactericidal component , and (B) a citrate, benzoate, malate, inosinate, guanylate as a bactericidal effect enhancing component. And one or more selected from acetate, succinate, sorbate, carbonate, sulfite, and phosphate in water, and the second constitution of the present invention. According to (A) a grapefruit seed extract as a virus inactivating component, and (B) a virus inactivating potency enhancing component, citrate, benzoate, malate, inosinate, guanylate, By mixing one or more selected from acetate, succinate, sorbate, carbonate, sulfite, and phosphate with water, hypochlorite is used as a bactericidal or virus inactivating component. The composition is a bactericidal or virus inactivating agent composition that does not contain chloric acid or alcohol, is hypoallergenic, and has a high bactericidal or virus inactivating effect.
また、本発明の第３の構成によれば、上記第１又は第２の構成の殺菌またはウイルス不活性化剤組成物のｐＨを６〜１１とすることにより、酸性や強アルカリ性の殺菌またはウイルス不活性化剤組成物に比べて皮膚に対する刺激性も少なく、使用感に優れた殺菌またはウイルス不活性化剤組成物となる。 Moreover, according to the 3rd structure of this invention, the pH of the sterilization or virus inactivating agent composition of the said 1st or 2nd structure is set to 6-11, and acid or strong alkaline sterilization or virus is carried out. The bactericidal or virus inactivating agent composition is less irritating to the skin as compared with the inactivating agent composition and is excellent in usability.
また、本発明の第４の構成によれば、上記第１又は第３の構成の殺菌剤組成物において、殺菌効力増強成分として、クエン酸三ナトリウム、クエン酸三カリウム、イノシン酸二ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、炭酸水素ナトリウム、炭酸ナトリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムから選ばれた１種又は２種以上を用いることにより、より殺菌効力が高く安全性にも優れた殺菌剤組成物となる。 Moreover, according to the 4th structure of this invention, in the bactericide composition of the said 1st or 3rd structure, as a bactericidal effect enhancing component, trisodium citrate, tripotassium citrate, disodium inosinate, amber Sterilization with higher bactericidal effect and superior safety by using one or more selected from disodium acid salt, potassium sorbate, sodium hydrogen carbonate, sodium carbonate, sodium sulfite, and disodium hydrogen phosphate. It becomes an agent composition.
また、本発明の第５の構成によれば、上記第１、第３、第４のいずれかの構成の殺菌剤組成物において、殺菌成分であるグレープフルーツ種子抽出物の配合量を０．００５質量％以上とすることにより、グレープフルーツ種子抽出物の配合量を、十分な殺菌効力を発揮するために必要な配合量とすることができる。 Moreover, according to the 5th structure of this invention, the compounding quantity of the grapefruit seed extract which is a bactericidal component is 0.005 mass in the bactericidal composition of said 1st , 3rd, or 4th structure. By setting it to be at least %, the blending amount of the grapefruit seed extract can be set to a blending amount necessary for exhibiting a sufficient bactericidal effect.
また、本発明の第６の構成によれば、上記第１、第３乃至第５のいずれかの構成の殺菌剤組成物において、殺菌効力増強成分の配合量を０．０００５質量％以上とすることにより、殺菌効力増強成分の配合量を、殺菌成分であるグレープフルーツ種子抽出物の殺菌効力を十分に増強するために必要な配合量とすることができる。 Moreover, according to the 6th structure of this invention, the compounding quantity of the bactericidal efficacy enhancing component is 0.0005 mass% or more in the bactericidal composition of any of the said 1st , 3rd thru|or 5th structures. As a result, the blending amount of the bactericidal efficacy enhancing component can be set to a blending amount necessary for sufficiently enhancing the bactericidal efficacy of the grapefruit seed extract which is the bactericidal component.
また、本発明の第７の構成によれば、上記第２又は第３の構成のウイルス不活性化剤組成物において、ウイルス不活性化効力増強成分として、クエン酸三ナトリウム、クエン酸三カリウム、炭酸水素ナトリウムから選ばれた１種又は２種以上を用いることにより、よりウイルス不活性化効力が高く安全性にも優れたウイルス不活性化剤組成物となる。 Moreover, according to the 7th structure of this invention, in the virus inactivating agent composition of the said 2nd or 3rd structure, trisodium citrate, tripotassium citrate, as a virus inactivating potency enhancing component, By using one or more selected from sodium hydrogen carbonate, a virus inactivating agent composition having a higher virus inactivating effect and an excellent safety can be obtained.
また、本発明の第８の構成によれば、上記第２、第３、第７のいずれかの構成のウイルス不活性化剤組成物において、ウイルス不活性化成分であるグレープフルーツ種子抽出物の配合量を０．１質量％以上とすることにより、グレープフルーツ種子抽出物の配合量を、十分なウイルス不活性化効力を発揮するために必要な配合量とすることができる。 According to an eighth aspect of the present invention, in the virus inactivating agent composition of any one of the second, third and seventh configurations, the grapefruit seed extract, which is a virus inactivating component, is blended. By setting the amount to 0.1% by mass or more, the blending amount of the grapefruit seed extract can be set to a blending amount required to exert a sufficient virus inactivating effect.
また、本発明の第９の構成によれば、上記第２、第３、第７、第８のいずれかの構成のウイルス不活性化剤組成物において、ウイルス不活性化効力増強成分の配合量を０．０１質量％以上とすることにより、ウイルス不活性化効力増強成分の配合量を、ウイルス不活性化成分であるグレープフルーツ種子抽出物のウイルス不活性化効力を十分に増強するために必要な配合量とすることができる。 Further, according to the ninth constitution of the present invention, in the virus inactivating agent composition of any of the second, third, seventh and eighth constitutions, the compounding amount of the virus inactivating potency enhancing component is Is 0.01% by mass or more, the amount of the virus inactivating potency enhancing component blended is required to sufficiently enhance the virus inactivating potency of the grapefruit seed extract which is the virus inactivating component. It can be a blending amount.
また、本発明の第１０の構成によれば、上記第２、第３、第７乃至第９のいずれかの構成のウイルス不活性化剤組成物をノンエンベロープウイルスに対して接触させることにより、従来のウイルス除去剤では不活性化が困難であったノロウイルス等のノンエンベロープウイルスの不活性化方法となる。 Further, according to the tenth constitution of the present invention, by bringing the virus inactivating agent composition of the second, third, seventh to ninth constitution into contact with a non-enveloped virus, It is a method for inactivating non-enveloped viruses such as norovirus, which was difficult to inactivate with conventional virus removing agents.
また、本発明の第１１の構成によれば、（Ａ）殺菌成分としてグレープフルーツ種子抽出物と、（Ｃ）水と、を含有する殺菌剤組成物に、（Ｂ）殺菌効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上を添加することにより、また、本発明の第１２の構成によれば、（Ａ）ウイルス不活性化成分としてグレープフルーツ種子抽出物と、（Ｃ）水と、を含有するウイルス不活性化剤組成物に、（Ｂ）ウイルス不活性化効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上を添加することにより、殺菌またはウイルス不活性化成分であるグレープフルーツ種子抽出物の殺菌またはウイルス不活性化効力を向上させることができ、高い殺菌またはウイルス不活性化力を備えた殺菌またはウイルス不活性化剤組成物を製造可能となる。 According to the eleventh configuration of the present invention, a fungicidal composition containing (A) a grapefruit seed extract as a bactericidal component and (C) water, and (B) citric acid as a bactericidal efficacy enhancing component. Add one or more selected from salt, benzoate, malate, inosinate, guanylate, acetate, succinate, sorbate, carbonate, sulfite and phosphate. According to the twelfth configuration of the present invention, a virus inactivating agent composition containing (A) grapefruit seed extract as a virus inactivating component and (C) water, (B) Citrate, benzoate, malate, inosinate, guanylate, acetate, succinate, sorbate, carbonate, sulfite, phosphoric acid as a virus inactivating potency enhancing component by adding one or more selected from the salts, it is possible to improve the sterilization or virus inactivation efficacy of grapefruit seed extract is sterilized or viral inactivation ingredient, high bactericidal or viruses not It becomes possible to produce a bactericidal or virus inactivating agent composition having an activating power.
また、本発明の第１３の構成によれば、上記第１１の構成の殺菌効力増強方法において、殺菌効力増強成分として、クエン酸三ナトリウム、クエン酸三カリウム、イノシン酸二ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、炭酸水素ナトリウム、炭酸ナトリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムから選ばれた１種又は２種以上を用いることにより、より殺菌効力が高く安全性にも優れた殺菌剤組成物を製造可能となる。 According to a thirteenth configuration of the present invention, in the bactericidal efficacy enhancing method of the eleventh configuration, as the bactericidal efficacy enhancing component, trisodium citrate, tripotassium citrate, disodium inosinate, disodium succinate is used. , A bactericidal composition having a higher bactericidal effect and an excellent safety by using one or more selected from the group consisting of, potassium sorbate, sodium hydrogen carbonate, sodium carbonate, sodium sulfite and disodium hydrogen phosphate. Can be manufactured.
また、本発明の第１４の構成によれば、上記第１２の構成のウイルス不活性化効力増強方法において、ウイルス不活性化効力増強成分として、クエン酸三ナトリウム、クエン酸三カリウム、炭酸水素ナトリウムから選ばれた１種又は２種以上を用いることにより、よりウイルス不活性化効力が高く安全性にも優れたウイルス不活性化剤組成物を製造可能となる。 According to the fourteenth configuration of the present invention, in the method for enhancing the virus inactivating potency of the twelfth configuration, trisodium citrate, tripotassium citrate, sodium hydrogen carbonate are used as the virus inactivating potency enhancing component. By using one or two or more selected from the above, it becomes possible to produce a virus inactivating agent composition having a higher virus inactivating effect and an excellent safety.
また、本発明の第１５の構成によれば、上記第１３又は第１４の構成の殺菌またはウイルス不活性化効力増強方法において、殺菌またはウイルス不活性化効力増強成分として、化学製品として汎用されており入手が容易な炭酸水素ナトリウムを用いることにより、低い配合量で殺菌またはウイルス不活性化成分であるグレープフルーツ種子抽出物の殺菌またはウイルス不活性化効力をより効果的に向上させることができ、高い殺菌またはウイルス不活性化効力と安全性とを兼ね備えた殺菌またはウイルス不活性化剤組成物を簡単に且つ低コストで製造可能となる。 According to a fifteenth configuration of the present invention, in the sterilization or virus inactivation efficacy enhancing method of the thirteenth or fourteenth configuration, it is widely used as a chemical product as a sterilization or virus inactivation efficacy enhancing component. By using sodium hydrogencarbonate, which is easily available in the market, it is possible to more effectively improve the sterilization or virus inactivating effect of the grapefruit seed extract, which is a sterilizing or virus inactivating component, in a low blending amount, and is high. A sterilizing or virus inactivating agent composition having both sterilizing or virus inactivating effect and safety can be easily produced at low cost.
また、本発明の第１６の構成によれば、上記第１１、第１３、第１５のいずれかの構成の殺菌効力増強方法において、殺菌効力増強成分の配合量を０．０００５質量％以上とすることにより、殺菌効力増強成分の配合量を殺菌成分であるグレープフルーツ種子抽出物の殺菌効力を向上させるために必要な配合量とすることができる。 Further, according to the 16th configuration of the present invention, in the bactericidal efficacy enhancing method of any of the 11th, 13th and 15th configurations, the blending amount of the bactericidal efficacy enhancing component is 0.0005 mass% or more. Thereby, the blending amount of the bactericidal efficacy enhancing component can be set to a blending amount necessary for improving the bactericidal efficacy of the grapefruit seed extract which is the bactericidal component.
また、本発明の第１７の構成によれば、上記第１２、第１４、第１５のいずれかのウイルス不活性化効力増強方法において、ウイルス不活性化効力増強成分の配合量を０．０１質量％以上とすることにより、ウイルス不活性化効力増強成分の配合量をウイルス不活性化成分であるグレープフルーツ種子抽出物のウイルス不活性化効力を向上させるために必要な配合量とすることができる。 Further, according to the seventeenth constitution of the present invention, in the virus inactivating potency enhancing method of any one of the twelfth , fourteenth and fifteenth aspects, the amount of the virus inactivating potency enhancing component is 0.01 mass. When the content is at least %, the amount of the virus inactivating potency enhancing component can be made to be the amount required for improving the virus inactivating potency of the grapefruit seed extract which is the virus inactivating component.
以下、本発明の殺菌、ウイルス不活性化剤組成物について詳細に説明する。本発明の殺菌、ウイルス不活性化剤組成物は、（Ａ）殺菌、ウイルス不活性化成分としてグレープフルーツ種子抽出物と、（Ｂ）殺菌、ウイルス不活性化効力増強成分として特定の有機酸塩及び／又は無機酸塩から選ばれた１種又は２種以上と、を（Ｃ）水に混合して水溶液としたものである。 Hereinafter, the sterilizing and virus inactivating agent composition of the present invention will be described in detail. The sterilizing and virus inactivating agent composition of the present invention comprises (A) a sterilizing and virus inactivating component, a grapefruit seed extract, and (B) a sterilizing and virus inactivating potency enhancing component, and a specific organic acid salt and And/or one or more selected from inorganic acid salts, and (C) is mixed with water to form an aqueous solution.
本発明の殺菌、ウイルス不活性化剤組成物に殺菌、ウイルス不活性化成分として配合される（Ａ）グレープフルーツ種子抽出物は、グレープフルーツの種子から抽出した天然由来の殺菌、抗菌、ウイルス不活性化成分であり、食品添加物として認められている。また、揮発性が小さく持続的な殺菌、抗菌、ウイルス不活性化活性を有する。従来、グレープフルーツ種子抽出物が単独である程度の殺菌効力を有することは知られていた。しかし、グレープフルーツ種子抽出物と、後述する特定の有機酸塩及び／又は無機酸塩とを併用することで、相乗的に殺菌、ウイルス不活性化効力を発揮することは、本発明者らによって初めて発見された知見である。 The (A) grapefruit seed extract, which is added to the bactericidal and virus inactivating agent composition of the present invention as a bactericidal and virus inactivating component, is a naturally-occurring bactericidal, antibacterial, and virus inactive extract extracted from grapefruit seeds. It is an ingredient and is recognized as a food additive. In addition, it has low volatility and has persistent bactericidal, antibacterial and virus inactivating activities. Heretofore, it has been known that grapefruit seed extract alone has a certain bactericidal effect. However, by using the grapefruit seed extract in combination with a specific organic acid salt and/or inorganic acid salt described below, synergistic bactericidal and virus inactivating effects can be exerted for the first time by the present inventors. This is the discovered finding.
本発明の殺菌、ウイルス不活性化剤組成物におけるグレープフルーツ種子抽出物の配合量は、特に限定されないものの、配合量が少なすぎる場合は十分な殺菌、ウイルス不活性化効力が得られない可能性がある。後述の実施例において示すように、十分な殺菌効力を得るためには、グレープフルーツ種子抽出物を殺菌剤組成物全体に対して０．００５質量％以上配合することが好ましい。また、十分なウイルス不活性化効力を得るためには、グレープフルーツ種子抽出物を殺菌剤組成物全体に対して０．０１質量％以上配合することが好ましい。 Sterilization of the present invention, the amount of the grapefruit seed extract in the virus inactivating agent composition is not particularly limited, but if the amount is too small, sufficient sterilization, virus inactivating effect may not be obtained. is there. As will be shown in Examples described later, in order to obtain a sufficient bactericidal effect, it is preferable to blend the grapefruit seed extract in an amount of 0.005% by mass or more based on the entire bactericidal composition. Further, in order to obtain a sufficient virus inactivating effect, it is preferable to blend the grapefruit seed extract in an amount of 0.01% by mass or more based on the entire fungicide composition.
一方、グレープフルーツ種子抽出物の配合量が多すぎる場合、殺菌、ウイルス不活性化効力の顕著な向上が期待できない上に、非常に高価なものになり、汎用性がなくなってしまう。配合量と殺菌、ウイルス不活性化効力とのバランスを考慮すると、グレープフルーツ種子抽出物の配合量を殺菌またはウイルス不活性化剤組成物全体に対して１０．０質量％以下とすることが好ましく、５．０質量％以下とすることがより好ましく、１．０質量％以下とすることがさらに好ましい。 On the other hand, if the blended amount of the grapefruit seed extract is too large, it is not possible to expect a significant improvement in the sterilization and virus inactivating effects, and it becomes very expensive and loses its versatility. Considering the balance between the blending amount and sterilization, virus inactivating efficacy, it is preferable that the blending amount of the grapefruit seed extract is 10.0% by mass or less based on the entire sterilizing or virus inactivating agent composition, It is more preferably 5.0% by mass or less, and further preferably 1.0% by mass or less.
本発明の殺菌、ウイルス不活性化剤組成物に（Ｂ）殺菌、ウイルス不活性化効力増強成分として配合される有機酸塩は、有機酸のナトリウム塩、カリウム塩等が挙げられる。１つの水酸基を有し、窒素原子を有さない２価以上のカルボン酸塩、水酸基と窒素原子を有さない１価以上のカルボン酸塩、ヌクレオシド一リン酸塩が挙げられる。１つの水酸基を有し、窒素原子を有さない２価以上のカルボン酸塩としては、炭素数２〜８であるカルボン酸塩が挙げられ、具体的には、クエン酸三ナトリウム二水和物、クエン酸三カリウム一水和物等のクエン酸塩、ＤＬ−リンゴ酸二ナトリウム１／２水和物等のリンゴ酸塩、ＤＬ−イソクエン酸三ナトリウム等のイソクエン酸塩等が挙げられる。水酸基と窒素原子を有さない１価以上のカルボン酸塩としては、炭素数２〜８であるカルボン酸塩が挙げられ、具体的には、安息香酸ナトリウム等の安息香酸塩、酢酸ナトリウム等の酢酸塩、コハク酸二ナトリウム等のコハク酸塩、ソルビン酸カリウム等のソルビン酸塩、プロピオン酸ナトリウム等のプロピオン酸塩、酪酸ナトリウム等の酪酸塩、吉草酸ナトリウム等の吉草酸塩、カプロン酸カリウム等のカプロン酸塩、フタル酸水素カリウム等のフタル酸塩、シュウ酸カリウム一水和物等のシュウ酸塩、マロン酸二ナトリウム等のマロン酸塩、アジピン酸二ナトリウム等のアジピン酸塩、グルタル酸二ナトリウム等のグルタル酸塩、マレイン酸二ナトリウム等のマレイン酸塩、フマル酸一ナトリウム等のフマル酸塩等が挙げられる。ヌクレオシド一リン酸塩としては、イノシン酸二ナトリウム等のイノシン酸塩、グアニル酸二ナトリウム等のグアニル酸塩、アデニル酸二ナトリウム等のアデニル酸塩、シチジル酸二ナトリウム等のシチジル酸塩、チミジル酸二ナトリウム等のチミジル酸塩、ウリジル酸二ナトリウム等のウリジル酸塩等が挙げられる。これら有機酸の中でも、クエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩が好ましい。これらの有機酸塩は単独で用いても良いし、２種以上を混合して用いても良い。 Examples of the organic acid salt to be blended in the bactericidal/virus inactivating agent composition of the present invention as the component (B) bactericidal/virus inactivating effect enhancing component include sodium salts and potassium salts of organic acids. Examples thereof include divalent or higher carboxylic acid salts having one hydroxyl group and no nitrogen atom, monovalent or higher carboxylic acid salts having no hydroxyl group and nitrogen atom, and nucleoside monophosphate salts. Examples of the divalent or higher carboxylic acid salt having one hydroxyl group and no nitrogen atom include a carboxylic acid salt having 2 to 8 carbon atoms, and specifically, trisodium citrate dihydrate. , Citrates such as tripotassium citrate monohydrate, malates such as DL-disodium malate hemihydrate, and isocitrates such as DL-isosodium citrate. Examples of the monovalent or higher carboxylic acid salt having no hydroxyl group and nitrogen atom include carboxylic acid salts having 2 to 8 carbon atoms, and specific examples include benzoic acid salts such as sodium benzoate and sodium acetate. Acetate, succinate such as disodium succinate, sorbate such as potassium sorbate, propionate such as sodium propionate, butyrate such as sodium butyrate, valerate such as sodium valerate, potassium caproate Such as caproate, phthalate such as potassium hydrogen phthalate, oxalate such as potassium oxalate monohydrate, malonate such as disodium malonate, adipate such as disodium adipate, glutar Examples thereof include glutarate salts such as disodium acid salt, maleate salts such as disodium maleate, and fumarate salts such as monosodium fumarate. The nucleoside monophosphates include inosinates such as disodium inosinate, guanylates such as disodium guanylate, adenylates such as disodium adenylate, cytidylates such as disodium cytidylate, and thymidylate. Examples thereof include thymidylates such as disodium and uridylates such as disodium uridylate. Among these organic acids, citrate, benzoate, malate, inosinate, guanylate, acetate, succinate and sorbate are preferable. These organic acid salts may be used alone or in combination of two or more.
本発明の殺菌、ウイルス不活性化剤組成物に（Ｂ）殺菌、ウイルス不活性化効力増強成分として配合される無機酸塩は、無機酸のナトリウム塩、カリウム塩等が挙げられ、その具体例としては、炭酸水素ナトリウム、炭酸ナトリウム一水和物等の炭酸塩、亜硫酸ナトリウム等の亜硫酸塩、リン酸水素二ナトリウム等のリン酸塩が挙げられる。これらの無機酸塩は単独で用いても良いし、２種以上を混合して用いても良い。また、前述した有機酸塩の１種又は２種以上と混合して用いても良い。 Examples of the inorganic acid salt to be added to the bactericidal/virus inactivating agent composition of the present invention as the component (B) bactericidal/virus inactivating efficacy enhancing component include sodium salts and potassium salts of inorganic acids, and specific examples thereof. Examples thereof include carbonates such as sodium hydrogen carbonate and sodium carbonate monohydrate, sulfites such as sodium sulfite, and phosphates such as disodium hydrogen phosphate. These inorganic acid salts may be used alone or in combination of two or more. Moreover, you may use it in mixture with 1 type, or 2 or more types of the above-mentioned organic acid salt.
上記の有機酸塩の中でも、特にクエン酸三ナトリウム二水和物、クエン酸三カリウム一水和物、イノシン酸二ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウムを用いることで、低い配合量で殺菌成分であるグレープフルーツ種子抽出物の殺菌効力を顕著に向上することができる。また、クエン酸三ナトリウム二水和物、クエン酸三カリウム一水和物を用いることで、低い配合量でウイルス不活性化成分であるグレープフルーツ種子抽出物のウイルス不活性化効力を顕著に向上することができる。 Among the above organic acid salts, especially by using trisodium citrate dihydrate, tripotassium citrate monohydrate, disodium inosinate, disodium succinate, potassium sorbate, sterilization with a low compounding amount It is possible to remarkably improve the bactericidal effect of the grapefruit seed extract which is a component. Further, by using trisodium citrate dihydrate and tripotassium citrate monohydrate, the virus inactivating effect of grapefruit seed extract, which is a virus inactivating component, can be significantly improved at a low compounding amount. be able to.
上記の無機酸塩の中でも、特に化学製品として汎用されており入手が容易で、且つ殺菌、ウイルス不活性化効力の増強効果も顕著である炭酸水素ナトリウムが好ましい。 Among the above-mentioned inorganic acid salts, sodium hydrogen carbonate is preferable because it is widely used as a chemical product, is easily available, and has a remarkable effect of enhancing sterilization and virus inactivating effects.
本発明の殺菌、ウイルス不活性化剤組成物のｐＨは６〜１１とすることが好ましい。これにより、殺菌、ウイルス不活性化剤組成物が中性〜弱アルカリ性となり、酸性や強アルカリ性の殺菌、ウイルス不活性化剤組成物に比べて皮膚に対する刺激性も少なく、使用感に優れた殺菌、ウイルス不活性化剤組成物となる。 The sterilization and virus inactivating agent composition of the present invention preferably has a pH of 6-11. As a result, sterilization, the virus inactivating agent composition becomes neutral to weakly alkaline, acid or strong alkaline sterilization, less irritating to the skin than the virus inactivating agent composition, and sterilization excellent in usability. , A virus inactivating agent composition.
本発明の殺菌、ウイルス不活性化剤組成物における殺菌、ウイルス不活性化効力増強成分の配合量は、特に限定されないものの、配合量が少なすぎる場合はグレープフルーツ種子抽出物の殺菌、ウイルス不活性化効力に対する十分な増強効果が得られない可能性がある。後述の実施例において示すように、十分な殺菌効力増強効果を得るためには、殺菌効力増強成分である有機酸塩及び／又は無機酸塩を殺菌剤組成物全体に対して０．０００５質量％以上配合することが好ましい。また、十分なウイルス不活性化効力増強効果を得るためには、ウイルス不活性化効力増強成分である有機酸塩及び／又は無機酸塩をウイルス不活性化剤組成物全体に対して０．０１質量％以上配合することが好ましい。 Sterilization of the present invention, sterilization in the virus inactivating agent composition, the amount of the virus inactivating potency enhancing component is not particularly limited, but if the amount is too small, sterilization of grapefruit seed extract, virus inactivation It may not be possible to obtain a sufficient potentiation effect on efficacy. As shown in Examples below, in order to obtain a sufficient bactericidal efficacy enhancing effect, 0.0005% by mass of an organic acid salt and/or an inorganic acid salt which is a bactericidal efficacy enhancing component is used with respect to the entire bactericidal composition. It is preferable to mix the above. Further, in order to obtain a sufficient effect of enhancing the virus inactivating effect, an organic acid salt and/or an inorganic acid salt which is a virus inactivating effect enhancing component is added to the whole virus inactivating agent composition in an amount of 0.01 It is preferable to blend in a mass% or more.
一方、殺菌、ウイルス不活性化効力増強成分の配合量が多すぎる場合、殺菌、ウイルス不活性化効力増強効果の顕著な向上が期待できない上に、殺菌、ウイルス不活性化剤組成物のコストが高くなる。配合量と殺菌、ウイルス不活性化効力増強効果とのバランスを考慮すると、殺菌、ウイルス不活性化効力増強成分の配合量を殺菌またはウイルス不活性化剤組成物全体に対して１０．０質量％以下とすることが好ましく、５．０質量％以下とすることがより好ましく、０．５質量％以下とすることがさらに好ましい。 On the other hand, sterilization, when the amount of the virus inactivating potency-enhancing component is too large, sterilization, a significant improvement in the virus inactivating potency-enhancing effect cannot be expected, and sterilization and the cost of the virus inactivating agent composition are high. Get higher Considering the balance between the blending amount and the bactericidal and virus inactivating potency enhancing effect, the blending amount of the bactericidal and virus inactivating potency enhancing component is 10.0% by mass based on the entire sterilizing or virus inactivating agent composition. The content is preferably the following, more preferably 5.0% by mass or less, and further preferably 0.5% by mass or less.
本発明の殺菌、ウイルス不活性化剤組成物は、従来に比べて短時間の処理で高い殺菌、ウイルス不活性化効果を発現する。後述の実施例において示すように、細菌に対しては１分以下、ウイルスに対しては５分以下の処理時間で十分な殺菌、ウイルス不活性化効果が認められた。 The bactericidal and virus inactivating agent composition of the present invention exhibits a high bactericidal and virus inactivating effect in a shorter treatment time as compared with conventional compositions. As shown in Examples described later, sufficient bactericidal and virus inactivating effects were observed with a treatment time of 1 minute or less for bacteria and 5 minutes or less for viruses.
本発明の殺菌、ウイルス不活性化剤組成物には、必要に応じて界面活性剤を配合することができる。例えば、界面活性剤には泡を発生する性質（泡立ち性）があり、泡立ち性に優れた界面活性剤を使用することで、本発明の殺菌、ウイルス不活性化剤組成物をトリガースプレー等で壁面にスプレーしたときの液ダレを抑制するとともに塗布領域も視認しやすくなる。 A surfactant may be added to the bactericidal and virus inactivating agent composition of the present invention, if necessary. For example, a surfactant has a property of generating foam (foaming property), and by using a surfactant having excellent foaming property, the sterilization of the present invention, the virus inactivating agent composition can be applied by a trigger spray or the like. The liquid dripping when sprayed on the wall surface is suppressed, and the application area is easily visible.
本発明の殺菌、ウイルス不活性化剤組成物に配合される界面活性剤としては、アニオン界面活性剤、カチオン界面活性剤、ノニオン界面活性剤、両性界面活性剤のいずれも好適に用いられる。本発明の殺菌、ウイルス不活性化剤組成物中における界面活性剤の配合量は、特に限定されないものの、０．１質量％以上１０質量％以下であることが好ましい。 Any of anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants can be preferably used as the surfactant incorporated in the bactericidal and virus inactivating agent composition of the present invention. The blending amount of the surfactant in the sterilization/virus inactivating agent composition of the present invention is not particularly limited, but is preferably 0.1% by mass or more and 10% by mass or less.
アニオン界面活性剤の例としては、例えば脂肪酸石けん、アルキルベンゼンスルホン酸塩、直鎖アルキルベンゼンスルホン酸塩、アルキル硫酸塩、α―オレフィンスルホン酸塩、アルキルリン酸エステル塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテルリン酸塩などが挙げられる。 Examples of the anionic surfactant include, for example, fatty acid soap, alkylbenzene sulfonate, linear alkylbenzene sulfonate, alkyl sulfate, α-olefin sulfonate, alkyl phosphate ester salt, polyoxyethylene alkyl ether sulfate, Examples thereof include polyoxyethylene alkylphenyl ether sulfate and polyoxyethylene alkyl ether phosphate.
カチオン界面活性剤の例としては、ラウリルトリメチルアンモニウムクロリド、塩化ベンザルコニウム等の第４級アンモニウム塩が挙げられる。 Examples of cationic surfactants include quaternary ammonium salts such as lauryl trimethyl ammonium chloride and benzalkonium chloride.
ノニオン界面活性剤の例としては、例えばポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレン高級脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ヤシ油脂肪酸ジエタノールアミド、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、脂肪酸アルカノールアミド、アルキルアミンオキシドなどが挙げられる。 Examples of nonionic surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene higher fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil. , Coconut oil fatty acid diethanolamide, polyoxyethylene polyoxypropylene alkyl ether, fatty acid alkanolamide, alkylamine oxide and the like.
両性界面活性剤の例としては、ベタイン型界面活性剤が挙げられる。具体的には、ラウリル−Ｎ，Ｎ−ジメチル酢酸ベタイン、ラウリルアミドプロピル−Ｎ，Ｎ−ジメチル酢酸ベタイン、ヤシアルキルアミドプロピル−Ｎ，Ｎ−ジメチルヒドロキシプロピルスルホベタイン等が挙げられる。 Examples of amphoteric surfactants include betaine-type surfactants. Specific examples include lauryl-N,N-dimethyl acetic acid betaine, lauryl amidopropyl-N,N-dimethyl acetic acid betaine, and cocoalkylamidopropyl-N,N-dimethylhydroxypropyl sulfobetaine.
本発明の殺菌、ウイルス不活性化剤組成物は、水系タイプであり、溶媒としては主に水が用いられる。水としては、イオン交換水や逆浸透膜水等の精製水や、通常の水道水や工業用水、海洋深層水等が挙げられる。 The sterilizing and virus inactivating agent composition of the present invention is of an aqueous type, and water is mainly used as a solvent. Examples of water include purified water such as ion-exchanged water and reverse osmosis water, ordinary tap water, industrial water, and deep sea water.
更に、本発明の殺菌、ウイルス不活性化剤組成物には、その他の成分として、必要に応じて、無機抗菌、ウイルス不活性化剤、有機抗菌、ウイルス不活性化剤、防藻剤、防錆剤、溶剤、キレート剤、香料、消臭成分等を、本発明の効果を損なわない範囲で配合することにより、抗菌効果、ウイルス不活性化効果、防藻効果、防錆効果、洗浄効果、芳香性、消臭性等を付与するようにしてもよい。 Further, the bactericidal and virus inactivating agent composition of the present invention may further contain, as necessary, inorganic antibacterial agents, virus inactivating agents, organic antibacterial agents, virus inactivating agents, antialgae agents, and antiprophylactic agents. Rust agents, solvents, chelating agents, fragrances, deodorant components, etc., by blending within the range that does not impair the effects of the present invention, antibacterial effect, virus inactivating effect, algae preventing effect, rust preventing effect, cleaning effect, Aroma, deodorant properties, etc. may be imparted.
こうして得られた本発明の殺菌、ウイルス不活性化剤組成物を、キッチンや浴室の排水口、タイル目地等、細菌やカビの発生しやすい箇所、ウイルス感染者が触れた場所、ウイルス感染者の嘔吐物を処理した場所、衣服等のウイルスで汚染された場所に塗布あるいはスプレーすることで、細菌やカビ、ウイルスを効果的に除去することができる。そして、本発明の殺菌、ウイルス不活性化剤組成物は、危険で取り扱いにくい次亜塩素酸殺菌剤や刺激臭のある酸性殺菌剤と異なり、安全に、かつ簡単に施用できるので極めて実用性が高いものである。 Thus obtained sterilization of the present invention, the virus inactivating agent composition, kitchen and bathroom drainage, tile joints, places where bacteria and mold are likely to occur, places where virus infected persons touch, virus infected persons' Bacteria, fungi, and viruses can be effectively removed by applying or spraying the vomit substance to a treated place or a place contaminated with a virus such as clothes. And, the sterilization and virus inactivating agent composition of the present invention is very practical because it is safe and easy to apply, unlike the dangerous and difficult-to-handle hypochlorous acid bactericide or the acidic bactericide having an irritating odor. It is expensive.
また、本発明のウイルス不活性化組成物は、インフルエンザウイルス等のエンベロープウイルスに加えて、ノロウイルス等のノンエンベロープウイルスに対しても高い不活性化効果を有する。従って、従来のウイルス除去剤では不活性化が困難であったノロウイルスの不活性化に好適に使用することができる。 Moreover, the virus inactivating composition of the present invention has a high inactivating effect against non-enveloped viruses such as Norovirus in addition to envelope viruses such as influenza virus. Therefore, it can be suitably used for inactivating norovirus, which was difficult to inactivate by conventional virus removing agents.
また、本発明の殺菌、ウイルス不活性化剤組成物は、殺菌、ウイルス不活性化成分としてグレープフルーツ種子抽出物と、殺菌、ウイルス不活性化効力増強成分として特定の有機酸塩及び／又は無機酸塩とを水に配合するだけの、非常に単純な組成であり、エタノール等のアルコールや銀系抗菌剤の配合を必須としない。そのため、製造が簡便なうえ、多くの殺菌、ウイルス不活性化剤で問題となる皮膚への刺激性も小さく、安全性が極めて高いものである。また、銀イオンによる変色の問題もないため、使用性にも優れている。 Further, the sterilization and virus inactivating agent composition of the present invention comprises a grapefruit seed extract as a sterilization and virus inactivating component, and a specific organic acid salt and/or an inorganic acid as a sterilization and virus inactivating potency enhancing component. It is a very simple composition that only salt and water are mixed, and it is not necessary to mix alcohol such as ethanol or silver antibacterial agent. Therefore, the production is simple, and the irritation to the skin, which is a problem with many sterilizing and virus inactivating agents, is small, and the safety is extremely high. Further, since there is no problem of discoloration due to silver ions, it is excellent in usability.
なお、本発明は上述した実施形態に限定されるものではなく、請求項に示した範囲で種々の変更が可能であり、異なる実施形態にそれぞれ開示された技術的手段を適宜組み合わせて得られる実施形態についても本発明の技術的範囲に含まれる。以下、実施例により本発明の効果について更に具体的に説明するが、本発明はこれらの実施例に制約されるものではない。 It should be noted that the present invention is not limited to the above-described embodiments, and various modifications can be made within the scope shown in the claims, and an embodiment obtained by appropriately combining the technical means disclosed in the different embodiments. The form is also included in the technical scope of the present invention. Hereinafter, the effects of the present invention will be described more specifically with reference to Examples, but the present invention is not limited to these Examples.
[試験液の調製]
（Ａ）グレープフルーツ種子抽出物（エービーシーテクノ社製）、（Ｂ）炭酸水素ナトリウム、クエン酸三ナトリウム二水和物、安息香酸ナトリウム、炭酸ナトリウム一水和物、クエン酸三カリウム一水和物、酢酸ナトリウム、リン酸水素二ナトリウム（以上、和光純薬工業社製）、コハク酸二ナトリウム、ソルビン酸カリウム、亜硫酸ナトリウム（以上、ナカライテスク社製）、ＤＬ−リンゴ酸二ナトリウム１／２水和物（扶桑化学工業社製）、イノシン酸二ナトリウム（PT.CJ.Indonasia社製）を表１、表２、表６に示す配合割合（質量％）で配合し、精製水を加えて１００重量％として試験液（本発明１〜３８）を得た。[Preparation of test solution]
(A) Grapefruit seed extract (manufactured by ABC Techno), (B) sodium hydrogen carbonate, trisodium citrate dihydrate, sodium benzoate, sodium carbonate monohydrate, tripotassium citrate monohydrate, Sodium acetate, disodium hydrogen phosphate (above, Wako Pure Chemical Industries, Ltd.), disodium succinate, potassium sorbate, sodium sulfite (above, Nacalai Tesque, Inc.), DL-disodium malate 1/2 hydrate Compound (manufactured by Fuso Chemical Industry Co., Ltd.) and disodium inosinate (manufactured by PT.CJ.Indonasia) at the compounding ratios (% by mass) shown in Tables 1, 2 and 6, and 100% by weight of purified water. The test liquid (the present invention 1 to 38) was obtained as a percentage.
（Ａ）グレープフルーツ種子抽出物（エービーシーテクノ社製）、ユズ種子抽出物（オリザ油化社製）（Ｂ）炭酸水素ナトリウム、クエン酸三ナトリウム二水和物、安息香酸ナトリウム、炭酸ナトリウム一水和物、クエン酸三カリウム一水和物、酢酸ナトリウム、リン酸水素二ナトリウム、グリシン、乳酸ナトリウム、水酸化ナトリウム（以上、和光純薬工業社製）、コハク酸二ナトリウム、ソルビン酸カリウム、亜硫酸ナトリウム、Ｄ−パントテン酸ナトリウム、ビタミンＢ１塩酸塩、Ｌ−アスパラギン酸ナトリウム、グルコン酸ナトリウム、（＋）酒石酸ナトリウムカリウム四水和物（以上、ナカライテスク社製）、ＤＬ−リンゴ酸二ナトリウム１／２水和物、エリソルビン酸ナトリウム（以上、扶桑化学工業社製）、イノシン酸二ナトリウム（PT.CJ.Indonasia社製）、エチレンジアミン四酢酸二ナトリウム（同仁化学研究所社製）、グリチルリチン酸二カリウム（丸善製薬社製）を表３、表４、表５、表７に示す配合割合（質量％）で配合し、精製水を加えて１００重量％として試験液（比較例１〜３９）を得た。 (A) Grapefruit seed extract (manufactured by ABC Techno), Yuzu seed extract (manufactured by Oriza Yuka) (B) Sodium hydrogen carbonate, trisodium citrate dihydrate, sodium benzoate, sodium carbonate monohydrate Substance, tripotassium citrate monohydrate, sodium acetate, disodium hydrogen phosphate, glycine, sodium lactate, sodium hydroxide (above, Wako Pure Chemical Industries, Ltd.), disodium succinate, potassium sorbate, sodium sulfite , D-sodium pantothenate, vitamin B1 hydrochloride, sodium L-aspartate, sodium gluconate, sodium potassium tartrate tetrahydrate (+, manufactured by Nacalai Tesque, Inc.), DL-disodium malate 1/2 Hydrate, sodium erythorbate (above, manufactured by Fuso Chemical Co., Ltd.), disodium inosinate (manufactured by PT.CJ.Indonasia), disodium ethylenediaminetetraacetate (manufactured by Dojindo Laboratories), dipotassium glycyrrhizinate ( (Manufactured by Maruzen Pharmaceutical Co., Ltd.) was blended at the blending proportions (mass %) shown in Tables 3, 4, 5, and 7, and purified water was added to 100% by weight to obtain test solutions (Comparative Examples 1 to 39). ..
［除菌効果の確認試験（Staphylococcus aureus）］
実施例１で調製した本発明１〜２６、比較例１〜３２の試験液９９０μＬに、黄色ブドウ球菌（S.aureus）の培養液１０μＬを接種してよく攪拌した後、混合液をＳＣＤＬＰ培地で１００倍希釈した。接種から希釈までの処理時間は３００秒、６０秒、３０秒、１５秒とした。この希釈液を滅菌済みのプラスチックシャーレに固化させておいたＳＣＤＬＰ寒天培地上に１００μＬ滴下し、コンラージ棒でよく延ばした後、３７℃で培養を行い、発生するコロニー数を計測した。また、対照例（ネガティブコントロール）として試験液の代わりに滅菌水を用いたものも用意した。試験液で処理したものと対照例のコロニー数の比較により除菌率を算出した。[Confirmation test of sterilization effect (Staphylococcus aureus)]
The test liquids of the present invention 1 to 26 and Comparative Examples 1 to 32 prepared in Example 1 were inoculated with 10 μL of the culture solution of S. aureus and well stirred, and then the mixture was mixed with SCDLP medium. Diluted 100 times. The processing time from inoculation to dilution was 300 seconds, 60 seconds, 30 seconds, and 15 seconds. 100 μL of this diluted solution was dropped on SCDLP agar medium which had been solidified on a sterilized plastic petri dish, and well spread with a conradi stick, followed by culturing at 37° C. and counting the number of colonies generated. Also, as a control example (negative control), a test solution using sterilized water instead of the test solution was prepared. The sterilization rate was calculated by comparing the number of colonies of the test solution and that of the control.
評価基準としては、除菌率が９９％以上の場合を◎、除菌率が９０％以上９９％未満の場合を○、除菌率が９０％未満の場合を×とした。除菌効果の試験結果を試験液の配合、ｐＨおよび処理時間と併せて表１〜表５に示す。 As the evaluation criteria, the case where the sterilization rate was 99% or more was marked with ⊚, the case where the sterilization rate was 90% or more and less than 99% was marked with ◯, and the case where the eradication rate was less than 90% was marked with x. The test results of the sterilization effect are shown in Tables 1 to 5 together with the formulation of the test solution, pH and treatment time.
表１〜表２に示すように、（Ａ）グレープフルーツ種子抽出物と、（Ｂ）炭酸水素ナトリウム、炭酸ナトリウム一水和物、クエン酸三ナトリウム二水和物、安息香酸ナトリウム、ＤＬ−リンゴ酸二ナトリウム１／２水和物、イノシン酸二ナトリウム、クエン酸三カリウム一水和物、酢酸ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムから選ばれる１種以上の有機酸又は無機酸塩とを配合した本発明１〜２６では、黄色ブドウ球菌（S.aureus）に対して除菌率が９０％以上となった。 As shown in Tables 1 and 2, (A) grapefruit seed extract and (B) sodium hydrogen carbonate, sodium carbonate monohydrate, trisodium citrate dihydrate, sodium benzoate, DL-malic acid. One or more selected from disodium hemihydrate, disodium inosinate, tripotassium citrate monohydrate, sodium acetate, disodium succinate, potassium sorbate, sodium sulfite, disodium hydrogen phosphate In the present inventions 1 to 26 containing the organic acid or the inorganic acid salt, the sterilization rate was 90% or more with respect to S. aureus.
特に、グレープフルーツ種子抽出物と、炭酸水素ナトリウム、炭酸ナトリウム一水和物、クエン酸三ナトリウム二水和物、イノシン酸二ナトリウム、クエン酸三カリウム一水和物、コハク酸二ナトリウム、ソルビン酸カリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムのいずれかを配合した本発明１〜４、７、８、１０〜１６では除菌率が９９％以上となり、短時間（１分間）の処理で細菌が完全に死滅した。さらに、グレープフルーツ種子抽出物の配合量を０．２０質量％とした本発明２０、２５では、より短時間（３０秒）の処理で細菌が完全に死滅し、グレープフルーツ種子抽出物の配合量を０．５０質量％とした本発明２１、２６では、一層短時間（１５秒）の処理で細菌が完全に死滅した。 In particular, grapefruit seed extract, sodium bicarbonate, sodium carbonate monohydrate, trisodium citrate dihydrate, disodium inosinate, tripotassium citrate monohydrate, disodium succinate, potassium sorbate In the present invention 1 to 4, 7, 8 and 10 to 16 containing any one of sodium sulfite and disodium hydrogen phosphate, the sterilization rate becomes 99% or more, and the bacteria are completely removed in a short time (1 minute) treatment. Died into. Furthermore, in the present invention 20 and 25 in which the content of the grapefruit seed extract was 0.20% by mass, the bacteria were completely killed by the treatment for a shorter time (30 seconds), and the content of the grapefruit seed extract was 0. In the present invention 21 and 26 in which the content was set to 0.50% by mass, the bacteria were completely killed by the treatment for a shorter time (15 seconds).
また、グレープフルーツ種子抽出物の配合量が０．００５質量％、炭酸水素ナトリウムの配合量が０．１０質量％である本発明１９、およびグレープフルーツ種子抽出物の配合量が０．００１質量％、炭酸水素ナトリウムの配合量が０．１０質量％である比較例３１の結果より、グレープフルーツ種子抽出物の配合量が０．００５質量％以上で即効的かつ十分な除菌効果が認められた。 The present invention 19 in which the amount of grapefruit seed extract is 0.005% by mass, the amount of sodium hydrogen carbonate is 0.10% by mass, and the amount of grapefruit seed extract is 0.001% by mass, carbonic acid From the results of Comparative Example 31 in which the content of sodium hydrogen was 0.10% by mass, a rapid and sufficient sterilization effect was observed when the content of the grapefruit seed extract was 0.005% by mass or more.
また、グレープフルーツ種子抽出物の配合量が０．１０質量％、炭酸水素ナトリウムの配合量が０．０００５質量％である本発明１７、およびグレープフルーツ種子抽出物の配合量が０．１０質量％、炭酸水素ナトリウムの配合量が０．０００１質量％である比較例３０の結果より、炭酸水素ナトリウムの配合量が０．０００５質量％以上で即効的かつ十分な除菌効果が認められた。 The present invention 17 in which the content of the grapefruit seed extract is 0.10% by mass and the content of sodium hydrogen carbonate is 0.0005% by mass, and the content of the grapefruit seed extract is 0.10% by mass, carbonic acid From the results of Comparative Example 30 in which the content of sodium hydrogen was 0.0001% by mass, it was confirmed that the content of sodium hydrogencarbonate was 0.0005% by mass or more, the immediate and sufficient bactericidal effect was obtained.
これに対し、表３〜表５に示すように、グレープフルーツ種子抽出物、炭酸水素ナトリウム、炭酸ナトリウム一水和物、クエン酸三ナトリウム二水和物、安息香酸ナトリウム、ＤＬ−リンゴ酸二ナトリウム１／２水和物、イノシン酸二ナトリウム、クエン酸三カリウム一水和物、酢酸ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムのみを配合した比較例１〜１４では除菌率が９０％未満となり、除菌効果が十分でなかった。 On the other hand, as shown in Tables 3 to 5, grapefruit seed extract, sodium hydrogen carbonate, sodium carbonate monohydrate, trisodium citrate dihydrate, sodium benzoate, DL-disodium malate 1 /2 hydrate, disodium inosinate, tripotassium citrate monohydrate, sodium acetate, disodium succinate, potassium sorbate, sodium sulfite, and Comparative Examples 1 to 14 in which only disodium hydrogen phosphate was blended. The eradication rate was less than 90%, and the eradication effect was not sufficient.
特に、グレープフルーツ種子抽出物の配合量が０．２質量％、炭酸水素ナトリウムの配合量が０．１質量％である本発明２０、およびグレープフルーツ種子抽出物の配合量が０．２質量％、クエン酸三ナトリウム二水和物の配合量が０．１質量％である本発明２５と、グレープフルーツ種子抽出物のみを０．２質量％配合した比較例１の結果より、グレープフルーツ種子抽出物のみの配合では、配合量を増加しても十分な除菌効果が認められないのに対し、グレープフルーツ種子抽出物と共に有機酸又は無機酸塩を配合することで即効的かつ十分な除菌効果が認められた。 In particular, the present invention 20 in which the content of grapefruit seed extract is 0.2% by mass and the content of sodium hydrogen carbonate is 0.1% by mass, and the content of grapefruit seed extract is 0.2% by mass, From the results of Comparative Example 1 in which the compounding amount of trisodium acid dihydrate is 0.1% by mass and Comparative Example 1 in which only 0.2% by mass of the grapefruit seed extract is compounded, only the grapefruit seed extract is compounded. On the other hand, although the sufficient bactericidal effect was not recognized even if the compounding amount was increased, the immediate and sufficient bactericidal effect was recognized by combining the organic acid or the inorganic acid salt with the grapefruit seed extract. ..
また、グレープフルーツ種子抽出物と共に、Ｄ−パントテン酸ナトリウム、乳酸ナトリウム、グリチルリチン酸二カリウム、ビタミンＢ１塩酸塩、グリシン、Ｌ−アスパラギン酸ナトリウム、グルコン酸ナトリウム、（＋）酒石酸ナトリウムカリウム四水和物、エリソルビン酸ナトリウム、エチレンジアミン四酢酸二ナトリウムのいずれかを配合した比較例１５〜２４、グレープフルーツ種子抽出物に代えてユズ種子抽出物を炭酸水素ナトリウムと併せて配合した比較例３２では十分な除菌効果は認められなかった。即ち、グレープフルーツ種子抽出物と配合する有機酸塩、無機酸塩の種類によって十分な除菌効果が認められるものと、除菌効果が十分でないものがあることが確認された。また、同じ柑橘系であってもユズ種子抽出物では除菌効果が認められないことが確認された。 Also, along with the grapefruit seed extract, D-sodium pantothenate, sodium lactate, dipotassium glycyrrhizinate, vitamin B1 hydrochloride, glycine, sodium L-aspartate, sodium gluconate, (+) sodium potassium tartrate tetrahydrate, Comparative Examples 15 to 24 containing sodium erythorbate or disodium ethylenediaminetetraacetate, and Comparative Example 32 containing Yuzu seed extract in combination with sodium hydrogencarbonate in place of the grapefruit seed extract had a sufficient sterilizing effect. Was not recognized. That is, it was confirmed that depending on the types of organic acid salts and inorganic acid salts to be blended with the grapefruit seed extract, a sufficient bactericidal effect was observed and a bactericidal effect was not sufficient. In addition, it was confirmed that even if the same citrus fruits were used, no disinfecting effect was observed with the Yuzu seed extract.
さらに、グレープフルーツ種子抽出物の水溶液に、水酸化ナトリウムを配合してｐＨを６．２〜９．８に調整した比較例２５〜２９では十分な除菌効果は認められなかった。即ち、グレープフルーツ種子抽出物を単にｐＨ６〜１１の中性〜弱アルカリ性環境下で使用することだけでは殺菌効力の向上は認められず、特定の有機酸塩、無機酸塩との併用によって相乗的に殺菌効力が向上することが確認された。 Further, in Comparative Examples 25 to 29 in which sodium hydroxide was added to the aqueous solution of the grapefruit seed extract to adjust the pH to 6.2 to 9.8, sufficient bactericidal effect was not observed. That is, no improvement in bactericidal efficacy was observed only by using the grapefruit seed extract in a neutral to weakly alkaline environment of pH 6 to 11, and synergistically by combining with a specific organic acid salt or inorganic acid salt. It was confirmed that the bactericidal efficacy was improved.
以上の結果から、グレープフルーツ種子抽出物と、炭酸水素ナトリウム、炭酸ナトリウム一水和物、クエン酸三ナトリウム二水和物、安息香酸ナトリウム、ＤＬ−リンゴ酸二ナトリウム１／２水和物、イノシン酸二ナトリウム、クエン酸三カリウム一水和物、酢酸ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムから選ばれた１種又は２種以上と、を水に配合することで、黄色ブドウ球菌に対する殺菌剤組成物として作用することが確認された。 From the above results, grapefruit seed extract, sodium hydrogen carbonate, sodium carbonate monohydrate, trisodium citrate dihydrate, sodium benzoate, DL-disodium malate hemihydrate, inosinic acid Mixing with water one or more selected from disodium, tripotassium citrate monohydrate, sodium acetate, disodium succinate, potassium sorbate, sodium sulfite, disodium hydrogen phosphate. Thus, it was confirmed that it acts as a fungicide composition against Staphylococcus aureus.
また、炭酸水素ナトリウム、炭酸ナトリウム一水和物、クエン酸三ナトリウム二水和物、安息香酸ナトリウム、ＤＬ−リンゴ酸二ナトリウム１／２水和物、イノシン酸二ナトリウム、クエン酸三カリウム一水和物、酢酸ナトリウム、コハク酸二ナトリウム、ソルビン酸カリウム、亜硫酸ナトリウム、リン酸水素二ナトリウムは、グレープフルーツ種子抽出物と共に配合することで、グレープフルーツ種子抽出物の殺菌効力増強成分として作用することが確認された。 Also, sodium hydrogen carbonate, sodium carbonate monohydrate, trisodium citrate dihydrate, sodium benzoate, DL-disodium malate hemihydrate, disodium inosinate, tripotassium citrate monohydrate. It has been confirmed that hydrate, sodium acetate, disodium succinate, potassium sorbate, sodium sulfite, disodium hydrogen phosphate, when combined with grapefruit seed extract, act as a bactericidal effect-enhancing component of grapefruit seed extract. Was done.
［ウイルス不活性化効果の確認試験（Feline calicivirus）］
（試験ウイルス液の調製）
ＭＥＭ培地（ナカライテスク社製）に牛胎仔血清を１０％加えた細胞増殖培地を用いてＣＲＦＫ細胞（ＪＣＲＢ細胞バンク）を組織培養シャーレ内に単層培養した。単層培養シャーレ内から細胞増殖培地を除去し、ネコカリシウイルス（Feline calicivirus F-9 ATCC VR-782）を接種した。次に、ＭＥＭ培地に牛胎仔血清を２％加えた細胞維持培地を加えて３７±１℃の炭酸ガスインキュベーター（ＣＯ2濃度５％）内で１〜５日間培養した。ネコカリシウイルスはノンエンベロープウイルスの一種であり、細胞培養できないノロウイルスの代替ウイルスとして広く使用されている。[Confirmation test of virus inactivating effect (Feline calicivirus)]
(Preparation of test virus solution)
CRFK cells (JCRB cell bank) were monolayer-cultured in a tissue culture dish using a cell growth medium containing 10% fetal bovine serum in MEM medium (Nacalai Tesque). The cell growth medium was removed from the inside of the monolayer culture dish and inoculated with feline calicivirus (Feline calicivirus F-9 ATCC VR-782). Next, a cell maintenance medium prepared by adding 2% fetal calf serum to the MEM medium was added, and the cells were cultured in a carbon dioxide gas incubator (CO 2 concentration 5%) at 37±1° C. for 1 to 5 days. Feline calicivirus is a type of non-enveloped virus and is widely used as a substitute virus for norovirus that cannot be cultured in cells.
培養後、倒立位相差顕微鏡を用いて細胞の形態を観察し、細胞に形態変化（細胞変性効果）が起こっていることを確認した。次に、培養液を１０００ｒｐｍ／分で３分間遠心分離し、得られた上澄み液を限外ろ過して試験ウイルス液とした。 After culturing, the morphology of the cells was observed using an inverted phase contrast microscope, and it was confirmed that the cells undergo morphological changes (cytopathic effect). Next, the culture solution was centrifuged at 1000 rpm/min for 3 minutes, and the obtained supernatant was ultrafiltered to obtain a test virus solution.
実施例１で調製した本発明２７〜３８、比較例３３〜３９の試験液０．９ｍＬに、試験ウイルス液０．１ｍＬを添加混合し、作用液とした。５分後に作用液をＭＥＭ培地で１００倍希釈し、１０倍希釈系列を作製した。なお、精製水に試験ウイルス液を添加したものを対照として同様の操作を行った。 0.1 mL of the test virus solution was added to 0.9 mL of the test solutions of the present invention 27 to 38 and Comparative Examples 33 to 39 prepared in Example 1 to prepare a working solution. After 5 minutes, the working solution was diluted 100-fold with MEM medium to prepare a 10-fold dilution series. In addition, the same operation was performed using a test virus solution added to purified water as a control.
（ウイルス感染価の測定）
細胞増殖培地を用い、使用細胞を組織培養用マイクロプレート（９６穴）内で単層培養した後、細胞増殖培地を除去して細胞維持培地を０．１ｍＬずつ加えた。次に、作用液の１０倍希釈系列０．１ｍＬをそれぞれ４穴ずつに接種し、３７±１℃の炭酸ガスインキュベーター（ＣＯ2濃度５％）内で４〜７日間培養した。培養後、倒立位相差顕微鏡を用いて細胞の形態変化（細胞変性効果）の有無を観察し、Ｒｅｅｄ−Ｍｕｅｎｃｈ法により５０％細胞培養感染量（ＴＣＩＤ50）を算出して作用液１ｍＬ当たりの感染価に換算し、対照とした精製水の感染価と比較して、感染価対数減少値を算出した。ウイルス感染価の測定結果を試験液の配合、ｐＨと併せて表６、表７に示す。(Measurement of virus infectivity)
The cells to be used were monolayer-cultured in a tissue culture microplate (96 wells) using a cell growth medium, the cell growth medium was removed, and 0.1 mL of each cell maintenance medium was added. Then, 0.1 mL of a 10-fold dilution series of the working solution was inoculated into each 4 wells, and cultured in a carbon dioxide incubator (CO 2 concentration 5%) at 37±1° C. for 4 to 7 days. After culturing, the presence or absence of cell morphological changes (cytopathic effect) was observed using an inverted phase contrast microscope, and the 50% cell culture infectious dose (TCID 50 ) was calculated by the Reed-Muench method to infect per 1 mL of the working solution. The value was converted into a titer and compared with the infectivity titer of purified water used as a control to calculate a logarithmic reduction value of the infectivity titer. The measurement results of the virus infectivity are shown in Tables 6 and 7 together with the formulation of the test solution and the pH.
表６に示すように、（Ａ）グレープフルーツ種子抽出物と、（Ｂ）炭酸水素ナトリウム、クエン酸三ナトリウム二水和物、クエン酸三カリウム一水和物のいずれかとを配合した本発明２７〜３８では、ネコカリシウイルス（Feline calicivirus）に対して感染価対数減少値が１以上となり、ウイルス不活性化効果を有することが確認された。 As shown in Table 6, the present invention 27 to which (A) grapefruit seed extract and (B) any one of sodium hydrogencarbonate, trisodium citrate dihydrate and tripotassium citrate monohydrate are blended. In No. 38, feline calicivirus (Feline calicivirus) had an infectious titer log reduction value of 1 or more, and thus it was confirmed that it has a virus inactivating effect.
特に、グレープフルーツ種子抽出物の配合量を０．５０質量％とした本発明２７、２９、３１、３６では、感染価対数減少値が２．８３よりも大きくなり、より一層顕著なウイルス不活性化効果が得られることが確認された。また、本発明２７、２９、３１、３６および比較例３３、３５の結果より、グレープフルーツ種子抽出物のみを０．５０質量％配合した場合でもウイルス不活性化効果が認められるが、炭酸水素ナトリウム、クエン酸三ナトリウム二水和物を配合することでウイルス不活性化効果が相乗的に高くなることが確認された。 In particular, in the present invention 27, 29, 31, 36 in which the content of the grapefruit seed extract was 0.50% by mass, the infectious titer logarithmic reduction value was larger than 2.83 and the virus inactivation was much more remarkable. It was confirmed that the effect was obtained. Further, from the results of the present invention 27, 29, 31, 36 and Comparative Examples 33, 35, a virus inactivating effect is recognized even when only 0.50% by mass of the grapefruit seed extract is blended, but sodium hydrogen carbonate, It was confirmed that the virus inactivating effect was synergistically increased by adding trisodium citrate dihydrate.
また、本発明２８、３０、３４、３７、３８および比較例３４、３６、３７の結果より、グレープフルーツ種子抽出物のみを０．２０質量％配合した場合はウイルス不活性化効果が認められないが、炭酸水素ナトリウム、クエン酸三ナトリウム二水和物、クエン酸三カリウム一水和物のいずれかを配合することでウイルス不活性化効果を発現することが確認された。 Further, from the results of the present invention 28, 30, 34, 37, 38 and Comparative Examples 34, 36, 37, when 0.20% by mass of the grapefruit seed extract alone was blended, no virus inactivating effect was observed. , Sodium bicarbonate, trisodium citrate dihydrate, or tripotassium citrate monohydrate was confirmed to exhibit a virus inactivating effect.
また、グレープフルーツ種子抽出物の配合量が０．１０質量％、クエン酸三ナトリウム二水和物の配合量が０．２０質量％である本発明３２、およびグレープフルーツ種子抽出物の配合量が０．０１質量％、クエン酸三ナトリウム二水和物の配合量が０．５０質量％である比較例３８の結果より、グレープフルーツ種子抽出物の配合量を０．１０質量％以上とすることで、クエン酸三ナトリウム二水和物の配合によりウイルス不活性化効果が相乗的に高くなることが確認された。 Further, the present invention 32 in which the blending amount of the grapefruit seed extract is 0.10 mass% and the blending amount of trisodium citrate dihydrate is 0.20 mass%, and the blending amount of the grapefruit seed extract is 0. From the result of Comparative Example 38 in which the blending amount of 01 mass% and trisodium citrate dihydrate is 0.50 mass%, the content of the grapefruit seed extract was set to 0.10 mass% or more, and It was confirmed that the virus inactivating effect was synergistically increased by the addition of trisodium acid dihydrate.
また、グレープフルーツ種子抽出物の配合量が０．５０質量％、クエン酸三ナトリウム二水和物の配合量が０．０１質量％である本発明３６、およびグレープフルーツ種子抽出物の配合量が０．５０質量％、クエン酸三ナトリウム二水和物の配合量が０．００１質量％である比較例３９の結果より、クエン酸三ナトリウム二水和物の配合量を０．０１質量％以上とすることで、グレープフルーツ種子抽出物によるウイルス不活性化効力の増強効果が発現することが確認された。 Further, the present invention 36 in which the blending amount of the grapefruit seed extract is 0.50% by mass and the blending amount of trisodium citrate dihydrate is 0.01% by mass, and the blending amount of the grapefruit seed extract is 0. From the result of Comparative Example 39 in which the content of trisodium citrate dihydrate is 50% by mass and the content of trisodium citrate dihydrate is 0.001% by mass, the content of trisodium citrate dihydrate is 0.01% by mass or more. Thus, it was confirmed that the grapefruit seed extract exhibited an effect of enhancing the virus inactivating effect.
以上の結果から、グレープフルーツ種子抽出物と、炭酸水素ナトリウム、クエン酸三ナトリウム二水和物、クエン酸三カリウム一水和物から選ばれた１種又は２種以上と、を水に配合することで、ネコカリシウイルスに対するウイルス不活性化剤組成物として作用することが確認された。 From the above results, blend the grapefruit seed extract and water with one or more selected from sodium hydrogen carbonate, trisodium citrate dihydrate and tripotassium citrate monohydrate. It was confirmed that the compound acts as a virus inactivating agent composition for feline calicivirus.
また、炭酸水素ナトリウム、クエン酸三ナトリウム二水和物、クエン酸三カリウム一水和物は、グレープフルーツ種子抽出物と共に配合することで、グレープフルーツ種子抽出物のウイルス不活性化効力増強成分として作用することが確認された。 Further, sodium hydrogen carbonate, trisodium citrate dihydrate, and tripotassium citrate monohydrate act as a virus inactivating potency-enhancing component of grapefruit seed extract by blending with grapefruit seed extract. It was confirmed.
なお、ここでは本発明のウイルス不活性化組成物によるエンベロープウイルスに対する不活性化効果は示していないが、エンベロープウイルスはノンエンベロープウイルスに比べて薬剤に対する感受性が高いため、本発明のウイルス不活性化組成物がエンベロープウイルスに対しても即効的な不活性効果を有するのはもちろんである。 Although the inactivating effect on the envelope virus by the virus inactivating composition of the present invention is not shown here, since the envelope virus is more sensitive to the drug than the non-envelope virus, the virus inactivating agent of the present invention is inactivated. It goes without saying that the composition also has an immediate inactivating effect also on enveloped viruses.
本発明は、殺菌、ウイルス不活性化成分として次亜塩素酸やアルコール、銀系抗菌剤を含まず、低刺激性で銀イオンによる変色のおそれもなく、安全性にも優れた殺菌、ウイルス不活性化剤組成物、および殺菌、ウイルス不活性化効力増強方法であり、特にキッチンや浴室、ウイルスで汚染された場所等に直接スプレー等により塗布される殺菌、ウイルス不活性化剤組成物として好適に用いられる。 The present invention does not contain hypochlorous acid, alcohol, or silver-based antibacterial agent as a bactericidal or virus inactivating component, is hypoallergenic, has no risk of discoloration due to silver ions, and has excellent safety in bactericidal or virus-free. Activator composition, and sterilization, virus inactivation efficacy enhancement method, particularly suitable as a sterilization and virus inactivating agent composition that is directly applied to kitchens, bathrooms, places contaminated with viruses, etc. by spraying, etc. Used for.
Claims (17)
（Ｂ）殺菌効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上を添加することを特徴とする殺菌効力増強方法（ただし、グレープフルーツ種子抽出物とベンジルアルコールとを含む殺菌剤組成物に、安息香酸ナトリウムを添加する場合、グレープフルーツ種子抽出物を含む殺菌剤組成物に酢酸ナトリウムを添加する場合、および／又はグレープフルーツ種子抽出物と澱粉加水分解物とを含む殺菌剤組成物に、炭酸水素ナトリウム、クエン酸ナトリウム、ソルビン酸カリウム、リン酸一ナトリウムから選ばれた１種以上を添加する場合を除く）。 (A) A germicidal composition containing a grapefruit seed extract as a germicidal component and (C) water,
(B) selected from citrate, benzoate, malate, inosinate, guanylate, acetate, succinate, sorbate, carbonate, sulfite and phosphate as a bactericidal efficacy enhancing component one or bacterial potentiation method killing you characterized by the addition of two or more members (however, the fungicidal composition comprising a benzyl alcohol grapefruit seed extract, when adding sodium benzoate, grapefruit When sodium acetate is added to a fungicide composition containing a seed extract, and/or a fungicide composition containing a grapefruit seed extract and a starch hydrolyzate, sodium hydrogen carbonate, sodium citrate, potassium sorbate, (Except when one or more selected from monosodium phosphate is added) .
（Ｂ）ウイルス不活性化効力増強成分としてクエン酸塩、安息香酸塩、リンゴ酸塩、イノシン酸塩、グアニル酸塩、酢酸塩、コハク酸塩、ソルビン酸塩、炭酸塩、亜硫酸塩、リン酸塩から選ばれた１種又は２種以上を添加することを特徴とするウイルス不活性化効力増強方法。 (A) A virus inactivating agent composition containing a grapefruit seed extract as a virus inactivating component and (C) water,
(B) Citrate, benzoate, malate, inosinate, guanylate, acetate, succinate, sorbate, carbonate, sulfite, phosphoric acid as a virus inactivating potency enhancing component features and to roux virus inactivation efficacy enhancing method the addition of one or more kinds selected from the salts.
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| JP2021050196A (en) * | 2020-07-22 | 2021-04-01 | フマキラー株式会社 | Bactericidal agent |
| JP2021050195A (en) * | 2020-07-22 | 2021-04-01 | フマキラー株式会社 | Bactericidal agent |
| JP2021059512A (en) * | 2019-10-08 | 2021-04-15 | フマキラー株式会社 | Virus inactivating agent |
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