KR102019530B1 - 피라진 키나아제 저해제 - Google Patents

피라진 키나아제 저해제 Download PDF

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KR102019530B1
KR102019530B1 KR1020147016958A KR20147016958A KR102019530B1 KR 102019530 B1 KR102019530 B1 KR 102019530B1 KR 1020147016958 A KR1020147016958 A KR 1020147016958A KR 20147016958 A KR20147016958 A KR 20147016958A KR 102019530 B1 KR102019530 B1 KR 102019530B1
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mmol
alkyl
ylamino
delete delete
amino
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KR20140093285A (ko
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용홍 송
칭 수
자오종 제이. 지아
브라이언 케인
숀 엠. 바우어
안잘리 판데이
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포톨라 파마슈티컬스, 인코포레이티드
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
KR1020147016958A 2011-11-23 2012-11-23 피라진 키나아제 저해제 Expired - Fee Related KR102019530B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563466P 2011-11-23 2011-11-23
US61/563,466 2011-11-23
PCT/US2012/066468 WO2013078466A1 (en) 2011-11-23 2012-11-23 Pyrazine kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20140093285A KR20140093285A (ko) 2014-07-25
KR102019530B1 true KR102019530B1 (ko) 2019-09-06

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US (2) US9359308B2 (OSRAM)
EP (1) EP2782579B1 (OSRAM)
JP (1) JP6039683B2 (OSRAM)
KR (1) KR102019530B1 (OSRAM)
CN (1) CN104066431B (OSRAM)
AU (1) AU2012340555B2 (OSRAM)
BR (1) BR112014012396B1 (OSRAM)
CA (2) CA2856301C (OSRAM)
CL (1) CL2014001346A1 (OSRAM)
CO (1) CO6990735A2 (OSRAM)
EA (1) EA026939B1 (OSRAM)
IL (1) IL232701A (OSRAM)
IN (1) IN2014CN04065A (OSRAM)
MX (1) MX363551B (OSRAM)
SG (2) SG10201601352UA (OSRAM)
WO (1) WO2013078466A1 (OSRAM)
ZA (1) ZA201403651B (OSRAM)

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US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
AU2009244897B2 (en) 2008-04-16 2014-11-13 Alexion Pharmaceuticals, Inc. 2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors
SG10201601352UA (en) 2011-11-23 2016-03-30 Portola Pharm Inc Pyrazine kinase inhibitors
US20130310387A1 (en) * 2012-05-16 2013-11-21 Novartis Ag Monocyclic Heteroaryl Cycloalkyldiamine Derivatives
RU2015116532A (ru) * 2012-10-19 2016-12-10 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы syk
KR20160093675A (ko) * 2013-12-05 2016-08-08 파마싸이클릭스 엘엘씨 브루톤 티로신 키나제의 억제제
WO2015138273A1 (en) * 2014-03-13 2015-09-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
CZ306322B6 (cs) 2014-12-17 2016-11-30 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující
RU2017145650A (ru) * 2015-06-02 2019-07-15 Фармасайкликс Элэлси Ингибиторы тирозинкиназы брутона
EP3801525A4 (en) * 2018-06-08 2022-03-23 The General Hospital Corporation PROLYL TRNA SYNTHETASE INHIBITORS
CN112047899A (zh) * 2020-10-19 2020-12-08 成都睿智化学研究有限公司 一种合成3-取代氨基苯并[c]异噻唑衍生物的方法
JP2025509598A (ja) * 2022-03-14 2025-04-11 パーデュー・リサーチ・ファウンデーション 脾臓チロシンキナーゼ阻害薬、組成物、および使用の方法

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Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20230903