KR102014565B1 - 부프레노르핀을 포함하는 경피 전달 시스템 - Google Patents

부프레노르핀을 포함하는 경피 전달 시스템 Download PDF

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KR102014565B1
KR102014565B1 KR1020147019186A KR20147019186A KR102014565B1 KR 102014565 B1 KR102014565 B1 KR 102014565B1 KR 1020147019186 A KR1020147019186 A KR 1020147019186A KR 20147019186 A KR20147019186 A KR 20147019186A KR 102014565 B1 KR102014565 B1 KR 102014565B1
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buprenorphine
hours
pressure sensitive
sensitive adhesive
adhesive layer
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Korean (ko)
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KR20140101858A (ko
Inventor
토마스 힐레
가브리엘 바우어
케빈 존 스미스
질리언 엘리자베스 문딘
헬렌 엘리자베스 존슨
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에르테에스 로만 테라피-시스테메 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147019186A 2011-12-12 2012-12-12 부프레노르핀을 포함하는 경피 전달 시스템 Active KR102014565B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161569609P 2011-12-12 2011-12-12
US61/569,609 2011-12-12
PCT/IB2012/002973 WO2013088254A1 (en) 2011-12-12 2012-12-12 Transdermal delivery system comprising buprenorphine

Publications (2)

Publication Number Publication Date
KR20140101858A KR20140101858A (ko) 2014-08-20
KR102014565B1 true KR102014565B1 (ko) 2019-08-26

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KR1020147019186A Active KR102014565B1 (ko) 2011-12-12 2012-12-12 부프레노르핀을 포함하는 경피 전달 시스템

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US (4) US20140363487A1 (enExample)
EP (1) EP2790685B1 (enExample)
JP (2) JP6289378B2 (enExample)
KR (1) KR102014565B1 (enExample)
CN (2) CN107669662A (enExample)
AP (1) AP4036A (enExample)
AR (1) AR089201A1 (enExample)
AU (1) AU2012327247B2 (enExample)
BR (1) BR112014014137A2 (enExample)
CA (1) CA2858531C (enExample)
CL (1) CL2014001559A1 (enExample)
CO (1) CO7000779A2 (enExample)
CR (1) CR20140321A (enExample)
DE (1) DE112012005185T5 (enExample)
EA (1) EA201491164A1 (enExample)
ES (1) ES2647516T3 (enExample)
GB (1) GB2512007B8 (enExample)
IL (1) IL233025A0 (enExample)
MX (1) MX352795B (enExample)
PE (1) PE20142341A1 (enExample)
PH (1) PH12014501231A1 (enExample)
PL (1) PL2790685T3 (enExample)
SG (2) SG11201403162XA (enExample)
TN (1) TN2014000233A1 (enExample)
TW (1) TW201338813A (enExample)
WO (1) WO2013088254A1 (enExample)

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JP6289378B2 (ja) 2018-03-07
US20170049713A1 (en) 2017-02-23
SG11201403162XA (en) 2014-10-30
CR20140321A (es) 2014-11-13
WO2013088254A1 (en) 2013-06-20
EP2790685B1 (en) 2017-08-16
US20200306204A1 (en) 2020-10-01
AU2012327247A1 (en) 2013-06-27
EP2790685A1 (en) 2014-10-22
AP2014007779A0 (en) 2014-07-31
IL233025A0 (en) 2014-07-31
JP2017036304A (ja) 2017-02-16
PH12014501231A1 (en) 2014-09-08
MX352795B (es) 2017-12-07
CO7000779A2 (es) 2014-07-21
KR20140101858A (ko) 2014-08-20
MX2014007020A (es) 2014-07-14
TN2014000233A1 (en) 2015-09-30
SG10201604754VA (en) 2016-08-30
GB2512007B (en) 2017-04-26
ES2647516T3 (es) 2017-12-22
GB2512007B8 (en) 2017-06-28
GB2512007A (en) 2014-09-17
CL2014001559A1 (es) 2014-10-03
CN104114161A (zh) 2014-10-22
GB201412385D0 (en) 2014-08-27
AR089201A1 (es) 2014-08-06
CN107669662A (zh) 2018-02-09
JP2015500329A (ja) 2015-01-05
HK1203048A1 (en) 2015-10-16
GB2512007A8 (en) 2017-06-28
EA201491164A1 (ru) 2014-10-30
US9549903B2 (en) 2017-01-24
HK1201760A1 (en) 2015-09-11
AU2012327247B2 (en) 2015-12-24
AP4036A (en) 2017-02-22
PE20142341A1 (es) 2015-01-17
DE112012005185T5 (de) 2014-08-28
US20160120823A1 (en) 2016-05-05
BR112014014137A2 (pt) 2017-06-13
NZ626535A (en) 2017-02-24
TW201338813A (zh) 2013-10-01
PL2790685T3 (pl) 2018-04-30
US20140363487A1 (en) 2014-12-11
CA2858531C (en) 2019-12-17
CA2858531A1 (en) 2013-06-20

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