KR102006200B1 - 매크로라이드의 결정 형태들 및 그 용도들 - Google Patents

매크로라이드의 결정 형태들 및 그 용도들 Download PDF

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KR102006200B1
KR102006200B1 KR1020127027222A KR20127027222A KR102006200B1 KR 102006200 B1 KR102006200 B1 KR 102006200B1 KR 1020127027222 A KR1020127027222 A KR 1020127027222A KR 20127027222 A KR20127027222 A KR 20127027222A KR 102006200 B1 KR102006200 B1 KR 102006200B1
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rti
cem
peaks
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ray powder
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KR20130056226A (ko
Inventor
데이비드 이. 페레이라
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셈프라 파마슈티컬스, 인크.
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Application filed by 셈프라 파마슈티컬스, 인크. filed Critical 셈프라 파마슈티컬스, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020127027222A 2010-03-22 2011-03-22 매크로라이드의 결정 형태들 및 그 용도들 Expired - Fee Related KR102006200B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31606310P 2010-03-22 2010-03-22
US61/316,063 2010-03-22
PCT/US2011/029424 WO2011119604A1 (en) 2010-03-22 2011-03-22 Crystalline forms of a macrolide, and uses therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020187025895A Division KR20180101643A (ko) 2010-03-22 2011-03-22 매크로라이드의 결정 형태들 및 그 용도들

Publications (2)

Publication Number Publication Date
KR20130056226A KR20130056226A (ko) 2013-05-29
KR102006200B1 true KR102006200B1 (ko) 2019-08-01

Family

ID=44673574

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020127027222A Expired - Fee Related KR102006200B1 (ko) 2010-03-22 2011-03-22 매크로라이드의 결정 형태들 및 그 용도들
KR1020187025895A Ceased KR20180101643A (ko) 2010-03-22 2011-03-22 매크로라이드의 결정 형태들 및 그 용도들

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187025895A Ceased KR20180101643A (ko) 2010-03-22 2011-03-22 매크로라이드의 결정 형태들 및 그 용도들

Country Status (19)

Country Link
US (4) US8975386B2 (https=)
EP (2) EP3009442B1 (https=)
JP (4) JP5711352B2 (https=)
KR (2) KR102006200B1 (https=)
CN (2) CN103080122A (https=)
AU (2) AU2011232627B2 (https=)
BR (1) BR112012023950A2 (https=)
CA (1) CA2793884C (https=)
DK (1) DK2550286T3 (https=)
ES (1) ES2564097T3 (https=)
HR (1) HRP20160168T1 (https=)
IL (1) IL222018B (https=)
MX (1) MX361413B (https=)
MY (1) MY162411A (https=)
NZ (1) NZ602544A (https=)
PL (1) PL2550286T3 (https=)
RU (1) RU2650883C2 (https=)
SI (1) SI2550286T1 (https=)
WO (1) WO2011119604A1 (https=)

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US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es) * 2010-03-22 2018-12-05 Cempra Pharmaceuticals Inc Star Formas cristalinas de un macrólido y usos para las mismas.
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EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
SG11201700827RA (en) * 2014-08-05 2017-03-30 Cempra Pharmaceuticals Inc Powder oral suspension formulations of antibacterial agents
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
CN106998685A (zh) 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
JP6112696B1 (ja) * 2015-10-05 2017-04-12 富山化学工業株式会社 ソリスロマイシンを含む錠剤
EP3190122A1 (en) * 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
WO2018045294A1 (en) * 2016-09-02 2018-03-08 Cempra Pharmaceuticals, Inc. Processes for preparing fluoroketolides
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WO2011119604A1 (en) 2011-09-29
BR112012023950A2 (pt) 2016-07-05
AU2016203986A1 (en) 2016-06-30
US20160244472A1 (en) 2016-08-25
JP6121387B2 (ja) 2017-04-26
AU2011232627B2 (en) 2016-03-17
US20130252915A1 (en) 2013-09-26
MY162411A (en) 2017-06-15
CN103080122A (zh) 2013-05-01
KR20180101643A (ko) 2018-09-12
US20190040096A1 (en) 2019-02-07
MX2012010895A (es) 2013-02-15
KR20130056226A (ko) 2013-05-29
MX361413B (es) 2018-12-05
CA2793884C (en) 2019-09-10
ES2564097T3 (es) 2016-03-17
US20130018008A1 (en) 2013-01-17
HK1177937A1 (en) 2013-08-30
EP2550286A1 (en) 2013-01-30
RU2650883C2 (ru) 2018-04-18
HRP20160168T1 (hr) 2016-03-25
SI2550286T1 (sl) 2016-04-29
PL2550286T3 (pl) 2016-07-29
US8975386B2 (en) 2015-03-10
CN108570083A (zh) 2018-09-25
JP2020002168A (ja) 2020-01-09
AU2011232627A1 (en) 2012-10-18
EP3009442A1 (en) 2016-04-20
AU2016203986B2 (en) 2016-10-06
IL222018B (en) 2019-05-30
RU2012144614A (ru) 2014-04-27
NZ602544A (en) 2014-11-28
EP2550286A4 (en) 2013-10-02
EP2550286B1 (en) 2015-12-09
JP2013522367A (ja) 2013-06-13
EP3009442B1 (en) 2019-06-19
JP2015063536A (ja) 2015-04-09
JP5711352B2 (ja) 2015-04-30
JP2017081953A (ja) 2017-05-18
CA2793884A1 (en) 2011-09-29
US8759500B2 (en) 2014-06-24
DK2550286T3 (en) 2016-02-29

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