KR101989762B1 - 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가 - Google Patents

락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가 Download PDF

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KR101989762B1
KR101989762B1 KR1020187016873A KR20187016873A KR101989762B1 KR 101989762 B1 KR101989762 B1 KR 101989762B1 KR 1020187016873 A KR1020187016873 A KR 1020187016873A KR 20187016873 A KR20187016873 A KR 20187016873A KR 101989762 B1 KR101989762 B1 KR 101989762B1
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nucleic acid
pdhk
heterologous nucleic
acid sequence
sirna
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KR20180069130A (ko
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메익시아 자우
브래들리 리차드 스네데코어
치 킨 도밍고스 엔지
에이미 셴
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제넨테크, 인크.
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KR1020187016873A 2010-05-28 2011-05-26 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가 Expired - Fee Related KR101989762B1 (ko)

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US34972710P 2010-05-28 2010-05-28
US61/349,727 2010-05-28
PCT/US2011/038191 WO2011150241A2 (en) 2010-05-28 2011-05-26 Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

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KR1020127033948A Division KR101869987B1 (ko) 2010-05-28 2011-05-26 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가

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KR1020197016381A Division KR20190067277A (ko) 2010-05-28 2011-05-26 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가

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KR20180069130A KR20180069130A (ko) 2018-06-22
KR101989762B1 true KR101989762B1 (ko) 2019-06-14

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KR1020187016873A Expired - Fee Related KR101989762B1 (ko) 2010-05-28 2011-05-26 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가
KR1020127033948A Expired - Fee Related KR101869987B1 (ko) 2010-05-28 2011-05-26 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가
KR1020197016381A Withdrawn KR20190067277A (ko) 2010-05-28 2011-05-26 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가

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KR1020197016381A Withdrawn KR20190067277A (ko) 2010-05-28 2011-05-26 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가

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EP (1) EP2576580B1 (cg-RX-API-DMAC10.html)
JP (3) JP6050226B2 (cg-RX-API-DMAC10.html)
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