KR101987861B1 - Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 - Google Patents

Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 Download PDF

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KR101987861B1
KR101987861B1 KR1020147014236A KR20147014236A KR101987861B1 KR 101987861 B1 KR101987861 B1 KR 101987861B1 KR 1020147014236 A KR1020147014236 A KR 1020147014236A KR 20147014236 A KR20147014236 A KR 20147014236A KR 101987861 B1 KR101987861 B1 KR 101987861B1
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pharmaceutically acceptable
acceptable salt
cancer
pyrimidin
hydroxycyclopentyl
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Korean (ko)
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KR20140097229A (ko
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피터 쥐. 스미스
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밀레니엄 파머슈티컬스 인코퍼레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147014236A 2011-11-03 2012-11-02 Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 Expired - Fee Related KR101987861B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161555049P 2011-11-03 2011-11-03
US61/555,049 2011-11-03
PCT/US2012/063382 WO2013067396A2 (en) 2011-11-03 2012-11-02 Administration of nedd8-activating enzyme inhibitor and hypomethylating agent

Publications (2)

Publication Number Publication Date
KR20140097229A KR20140097229A (ko) 2014-08-06
KR101987861B1 true KR101987861B1 (ko) 2019-06-11

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KR1020147014236A Expired - Fee Related KR101987861B1 (ko) 2011-11-03 2012-11-02 Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여

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Country Link
US (2) US8980850B2 (https=)
EP (1) EP2773360B1 (https=)
JP (2) JP6231988B2 (https=)
KR (1) KR101987861B1 (https=)
CN (1) CN104245699B (https=)
AU (1) AU2012321106C1 (https=)
BR (1) BR112014010699B1 (https=)
CA (1) CA2854461C (https=)
EA (1) EA028380B1 (https=)
ES (1) ES2668272T3 (https=)
GE (2) GEP20186940B (https=)
HK (1) HK1201733A1 (https=)
IL (1) IL232353B (https=)
MA (1) MA35662B1 (https=)
MX (1) MX357835B (https=)
MY (1) MY176125A (https=)
PH (1) PH12014501001B1 (https=)
PL (1) PL2773360T3 (https=)
SG (1) SG11201401895WA (https=)
TN (1) TN2014000194A1 (https=)
TR (1) TR201807342T4 (https=)
UA (1) UA114414C2 (https=)
WO (1) WO2013067396A2 (https=)

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SG175929A1 (en) 2009-05-14 2011-12-29 Millennium Pharm Inc Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
SG11201400102WA (en) * 2011-08-24 2014-03-28 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
EP2764866A1 (en) * 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
CA2923752A1 (en) 2013-05-14 2014-11-20 Millennium Pharmaceuticals, Inc. Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents
EP3024488A1 (en) * 2013-07-26 2016-06-01 Boehringer Ingelheim International GmbH Volasertib in combination with azacitidine for the treatment of acute myeloid leukemia and myelodysplastic syndrome ii
SG11201608303QA (en) 2014-04-04 2016-11-29 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
CN103948590A (zh) * 2014-05-22 2014-07-30 中国药科大学 Nedd8激活酶抑制剂及其医药用途
US10695352B2 (en) * 2015-10-15 2020-06-30 Celgene Corporation Combination therapy for treating malignancies
US11701406B2 (en) 2017-05-25 2023-07-18 The Board Of Trustees Of The Leland Stanford Junior University Combination of low dose IL-2 and an inhibitor of Treg IL-2R desensitization to treat autoimmune and allergic inflammatory diseases
WO2019060536A1 (en) * 2017-09-21 2019-03-28 Millennium Pharmaceuticals, Inc. CO-CRYSTALLINE FORMS OF ((1S, 2S, 4R) -4- {4 - [(1S) -2,3-DIHYDRO-1H-INDEN-1-YLAMINO] -7H-PYRROLO [2,3-D] PYRIMIDIN -7-YL} -2-HYDROXYCYCLOPENTYL) METHYLSULFAMATE, THEIR FORMULATIONS AND USES
WO2020106876A2 (en) * 2018-11-20 2020-05-28 Fulcrum Therapeutics, Inc. Compositions and methods for increasing fetal hemoglobin and treating sickle cell disease
WO2020190754A1 (en) 2019-03-15 2020-09-24 Fulcrum Therapeutics, Inc. Macrocyclic azolopyridine derivatives as eed and prc2 modulators
WO2023025668A1 (en) 2021-08-25 2023-03-02 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for the generation of stem cell memory t cells for adoptive t cell therapy
WO2023242235A1 (en) * 2022-06-14 2023-12-21 Scandion Oncology A/S Abcg2 inhibitor and nae inhibitor for the treatment of cancer
CN115007323B (zh) * 2022-06-17 2024-01-23 中南大学 一种抑制矿物中黄铁矿浮选的方法
US20260023068A1 (en) * 2022-07-11 2026-01-22 Westlake University Use of a fbxo42 specific inhibitor in treating notch signaling-dependent disease

Citations (2)

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WO2008019124A1 (en) 2006-08-08 2008-02-14 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of e1 activating enzymes
US20100292177A1 (en) 2009-03-23 2010-11-18 Armstrong Robert C Methods of treatment using combination therapy

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US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US20060063735A1 (en) 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
US20060128654A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
PT1848718E (pt) 2005-02-04 2012-10-11 Millennium Pharm Inc Inibidores de enzimas de activação e1
KR101450535B1 (ko) 2006-02-02 2014-10-14 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｅ１ 활성화 효소의 억제제
US20080057086A1 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
EP2211870A1 (en) 2007-11-01 2010-08-04 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
US20110021517A1 (en) * 2008-02-26 2011-01-27 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents
PL3692983T3 (pl) 2008-05-15 2021-12-27 Celgene Corporation Doustne formulacje analogów cytydyny i sposoby ich zastosowania
AU2009259136B2 (en) * 2008-06-09 2014-09-25 Cyclacel Limited Combinations of sapacitabine or CNDAC with DNA methyltransferase inhibitors such as decitabine and procaine
SG175929A1 (en) 2009-05-14 2011-12-29 Millennium Pharm Inc Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
JP2014503597A (ja) 2011-01-31 2014-02-13 セルジーン コーポレイション シチジンアナログの医薬組成物及びその使用方法
TW201700103A (zh) 2011-11-01 2017-01-01 西建公司 利用胞嘧啶核苷類似物之口服配方治療癌症的方法

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2008019124A1 (en) 2006-08-08 2008-02-14 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of e1 activating enzymes
US20100292177A1 (en) 2009-03-23 2010-11-18 Armstrong Robert C Methods of treatment using combination therapy

Non-Patent Citations (2)

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Title
Current Opinion in Oncology, 20(6), 705-710, 2008.
Expert Opinion on Therapeutic Targets, 15(3), 253-264, 2011.

Also Published As

Publication number Publication date
EA201400539A1 (ru) 2014-12-30
UA114414C2 (uk) 2017-06-12
KR20140097229A (ko) 2014-08-06
US8980850B2 (en) 2015-03-17
IL232353B (en) 2018-11-29
EP2773360A4 (en) 2015-09-23
ES2668272T3 (es) 2018-05-17
GEAP201813483A (en) 2018-09-10
MY176125A (en) 2020-07-24
US20150366886A1 (en) 2015-12-24
MA35662B1 (fr) 2014-11-01
AU2012321106C1 (en) 2016-11-24
JP6231988B2 (ja) 2017-11-15
HK1201733A1 (en) 2015-09-11
GEP20196940B (en) 2019-01-10
CN104245699A (zh) 2014-12-24
EA028380B1 (ru) 2017-11-30
PH12014501001B1 (en) 2018-05-04
GEP20186940B (en) 2019-01-10
US20130116208A1 (en) 2013-05-09
MX2014005323A (es) 2014-06-05
CN104245699B (zh) 2017-06-27
MX357835B (es) 2018-07-26
TN2014000194A1 (en) 2015-09-30
PL2773360T3 (pl) 2018-09-28
AU2012321106B2 (en) 2016-08-04
BR112014010699B1 (pt) 2020-12-15
BR112014010699A2 (pt) 2017-04-25
AU2012321106A1 (en) 2013-05-23
TR201807342T4 (tr) 2018-06-21
PH12014501001A1 (en) 2014-06-09
JP2015505816A (ja) 2015-02-26
WO2013067396A2 (en) 2013-05-10
CA2854461A1 (en) 2013-05-10
NZ624881A (en) 2016-10-28
CA2854461C (en) 2021-01-19
WO2013067396A3 (en) 2014-10-16
JP2018009035A (ja) 2018-01-18
SG11201401895WA (en) 2014-05-29
IL232353A0 (en) 2014-06-30
EP2773360A2 (en) 2014-09-10
EP2773360B1 (en) 2018-02-28

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