KR101987736B1 - 글루코실세라마이드 합성효소 억제제 - Google Patents

글루코실세라마이드 합성효소 억제제 Download PDF

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KR101987736B1
KR101987736B1 KR1020137027592A KR20137027592A KR101987736B1 KR 101987736 B1 KR101987736 B1 KR 101987736B1 KR 1020137027592 A KR1020137027592 A KR 1020137027592A KR 20137027592 A KR20137027592 A KR 20137027592A KR 101987736 B1 KR101987736 B1 KR 101987736B1
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methyl
heteroaryl
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KR20140092239A (ko
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일리스 부케
카산드라 셀라트카
브래드포드 허스
마르쿠스 메츠
중 자오
레나토 스케르리
이빈 샹
캐서린 잰시식스
존 마셜
썽 청
로날트 쇼일레
마리오 카브레라-살라자르
앤드류 굿
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젠자임 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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KR1020137027592A 2011-03-18 2012-03-16 글루코실세라마이드 합성효소 억제제 Active KR101987736B1 (ko)

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Application Number Priority Date Filing Date Title
US201161454034P 2011-03-18 2011-03-18
US61/454,034 2011-03-18
US201261590711P 2012-01-25 2012-01-25
US61/590,711 2012-01-25
PCT/US2012/029417 WO2012129084A2 (en) 2011-03-18 2012-03-16 Glucosylceramide synthase inhibitors

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KR20140092239A KR20140092239A (ko) 2014-07-23
KR101987736B1 true KR101987736B1 (ko) 2019-06-11

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US (5) US9139580B2 (https=)
EP (3) EP2685986B1 (https=)
JP (2) JP6117708B2 (https=)
KR (1) KR101987736B1 (https=)
CN (2) CN103917094B (https=)
AR (1) AR085425A1 (https=)
AU (2) AU2012231275A1 (https=)
BR (2) BR122019017719B1 (https=)
CA (1) CA2830540C (https=)
CL (1) CL2013002688A1 (https=)
CO (1) CO6801749A2 (https=)
CR (1) CR20190034A (https=)
DK (2) DK2685986T3 (https=)
DO (1) DOP2013000209A (https=)
EC (1) ECSP13012978A (https=)
ES (2) ES3037907T3 (https=)
FI (1) FI3673906T3 (https=)
GT (1) GT201300215A (https=)
HR (2) HRP20250907T1 (https=)
HU (2) HUE072576T2 (https=)
IL (1) IL228514B (https=)
LT (2) LT3673906T (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
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KR20150053972A (ko) * 2012-09-11 2015-05-19 젠자임 코포레이션 글루코실세라마이드 합성효소 억제제

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KR101987736B1 (ko) * 2011-03-18 2019-06-11 젠자임 코포레이션 글루코실세라마이드 합성효소 억제제
AU2019222801B2 (en) * 2012-09-11 2021-02-18 Genzyme Corporation Glucosylceramide synthase inhibitors
MX365464B (es) * 2013-03-15 2019-06-04 Genzyme Corp Prodecimiento para preparar inhibidores de la glucosilceramida sintasa.
JO3713B1 (ar) * 2013-03-15 2021-01-31 Genzyme Corp أشكال ملح (s)-كوينوكليدين-3-يل(2-(2-(4-فلوروفينيل)ثيازول-4-يل)بروبان-2-يل)كارباميت
CN104418851A (zh) * 2013-09-02 2015-03-18 上海龙翔生物医药开发有限公司 奎宁环衍生物的制备方法及纯化方法
EP3079695B1 (en) * 2013-12-11 2021-03-17 Genzyme Corporation Glucosylceramide synthase inhibitors
BR112016028081A2 (pt) * 2014-05-30 2017-08-22 Sphaera Pharma Private Ltd Novos compostos como agentes antituberculares
WO2016126572A2 (en) 2015-02-02 2016-08-11 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
TW201642855A (zh) * 2015-03-10 2016-12-16 健臻公司 用於治療蛋白質病變之方法
CN108290855A (zh) 2015-07-01 2018-07-17 西北大学 被取代的喹唑啉化合物及其调节葡糖脑苷脂酶活性的用途
US9802942B2 (en) 2015-07-01 2017-10-31 Northwestern University Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
AR107483A1 (es) 2016-01-29 2018-05-02 Hanmi Pharm Ind Co Ltd Conjugado de enzimas terapéuticas
KR20180124971A (ko) * 2016-03-25 2018-11-21 젠자임 코포레이션 단백질병증의 바이오마커 및 이의 용도
EP3318277A1 (en) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases
WO2018090054A1 (en) * 2016-11-14 2018-05-17 Berg Llc Methods for treating parkinson's disease
WO2018122746A1 (en) 2016-12-28 2018-07-05 Minoryx Therapeutics S.L. Isoquinoline compounds, methods for their preparation, and therapeutic uses thereof in conditions associated with the alteration of the activity of beta galactosidase
CN110325516A (zh) 2016-12-29 2019-10-11 米尼奥尔克斯治疗有限公司 杂芳基化合物和它们的用途
CN108341822B (zh) * 2017-01-23 2021-04-16 广州市恒诺康医药科技有限公司 Fxr受体调节剂及其制备方法和应用
WO2019099294A1 (en) * 2017-11-14 2019-05-23 Merck Sharp & Dohme Corp. Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
JP2021506920A (ja) 2017-12-21 2021-02-22 リソソーマル・セラピューティクス・インコーポレイテッドＬｙｓｏｓｏｍａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 結晶性の置換シクロヘキシルピラゾロ［１，５−ａ］ピリミジニルカルボキサミド化合物およびその治療的使用
WO2019151269A1 (ja) * 2018-01-31 2019-08-08 武田薬品工業株式会社 複素環化合物
US10519157B2 (en) * 2018-02-09 2019-12-31 X-Cutag Therapeutics, Inc. Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof
KR102342901B1 (ko) * 2018-11-22 2021-12-24 (주)프로스테믹스 엑소좀 및 이의 다양한 용도
KR102342902B1 (ko) * 2018-11-22 2021-12-24 (주)프로스테믹스 엑소좀 및 이의 다양한 용도
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