KR101978534B1 - 변형된 미생물 이를 테면 피치아 파스토리스(pichia pastoris)에서 다수의 아단위 단백질들, 이를 테면 항체의 고역가 및 고순도 생산을 위한 다중-복사체 전략 - Google Patents
변형된 미생물 이를 테면 피치아 파스토리스(pichia pastoris)에서 다수의 아단위 단백질들, 이를 테면 항체의 고역가 및 고순도 생산을 위한 다중-복사체 전략 Download PDFInfo
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P21/00—Preparation of peptides or proteins
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- C07K—PEPTIDES
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- C07K2319/00—Fusion polypeptide
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| PCT/US2012/051619 WO2013028635A1 (en) | 2011-08-19 | 2012-08-20 | Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as a antibodies in transformed microbes such as pichia pastoris |
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| US10202630B2 (en) | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
| ES2834113T3 (es) | 2013-03-15 | 2021-06-16 | H Lundbeck As | Purificación de anticuerpos y monitorización de la pureza |
| WO2014145650A1 (en) | 2013-03-15 | 2014-09-18 | Alder Biopharmaceuticals, Inc. | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
| JP6206873B2 (ja) * | 2013-09-30 | 2017-10-04 | 国立研究開発法人農業・食品産業技術総合研究機構 | ニワトリリゾチーム由来の分泌シグナルペプチドを用いたブタリゾチームの製造方法 |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| AU2015230933B2 (en) | 2014-03-21 | 2020-08-13 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| KR20220031944A (ko) | 2016-09-23 | 2022-03-14 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 불응성 편두통의 치료 |
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| WO2025141786A1 (ja) * | 2023-12-27 | 2025-07-03 | 中外製薬株式会社 | 抗体の製造方法 |
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| US20060270045A1 (en) | 2003-10-22 | 2006-11-30 | Keck Graduate Institute | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
| US20090028784A1 (en) | 2007-05-21 | 2009-01-29 | Alder Biopharmaceuticals, Inc. | Antibodies to IL-6 and use thereof |
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| US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| US4818700A (en) | 1985-10-25 | 1989-04-04 | Phillips Petroleum Company | Pichia pastoris argininosuccinate lyase gene and uses thereof |
| US4812405A (en) | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
| US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
| WO1994021293A1 (en) | 1993-03-19 | 1994-09-29 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
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2012
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| US20060270045A1 (en) | 2003-10-22 | 2006-11-30 | Keck Graduate Institute | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
| US20090028784A1 (en) | 2007-05-21 | 2009-01-29 | Alder Biopharmaceuticals, Inc. | Antibodies to IL-6 and use thereof |
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| IL230978A0 (en) | 2014-03-31 |
| EP2744903B1 (en) | 2018-10-10 |
| EP2744903A1 (en) | 2014-06-25 |
| KR20140057613A (ko) | 2014-05-13 |
| NZ621199A (en) | 2016-07-29 |
| WO2013028635A9 (en) | 2013-09-26 |
| BR112014003841A2 (pt) | 2017-03-14 |
| NZ721102A (en) | 2020-01-31 |
| EP2744903A4 (en) | 2014-12-31 |
| AU2012299035B2 (en) | 2017-11-02 |
| AU2012299035A1 (en) | 2014-03-13 |
| WO2013028635A1 (en) | 2013-02-28 |
| CA2845579A1 (en) | 2013-02-28 |
| SG2014011878A (en) | 2014-04-28 |
| SG10201609752YA (en) | 2017-01-27 |
| MX355890B (es) | 2018-05-03 |
| TWI666318B (zh) | 2019-07-21 |
| JP6138788B2 (ja) | 2017-05-31 |
| DK2744903T3 (en) | 2019-01-28 |
| IL230978B (en) | 2018-08-30 |
| TW201313899A (zh) | 2013-04-01 |
| JP2014525247A (ja) | 2014-09-29 |
| CN103890178A (zh) | 2014-06-25 |
| BR112014003841B1 (pt) | 2022-02-15 |
| MX2014001951A (es) | 2016-02-05 |
| AR087612A1 (es) | 2014-04-03 |
| MX383145B (es) | 2025-03-13 |
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