KR101860487B1 - N-[4-(1-시클로부틸 피페리딘-4-일옥시) 페닐]-2-(모르폴린-4-일) 아세트아미드 디히드로클로리드의 대규모 생산을 위한 방법 - Google Patents
N-[4-(1-시클로부틸 피페리딘-4-일옥시) 페닐]-2-(모르폴린-4-일) 아세트아미드 디히드로클로리드의 대규모 생산을 위한 방법 Download PDFInfo
- Publication number
- KR101860487B1 KR101860487B1 KR1020177005182A KR20177005182A KR101860487B1 KR 101860487 B1 KR101860487 B1 KR 101860487B1 KR 1020177005182 A KR1020177005182 A KR 1020177005182A KR 20177005182 A KR20177005182 A KR 20177005182A KR 101860487 B1 KR101860487 B1 KR 101860487B1
- Authority
- KR
- South Korea
- Prior art keywords
- hours
- yloxy
- cyclobutylpiperidin
- phenyl
- morpholin
- Prior art date
Links
- YNAVUWVOSKDBBP-UHFFFAOYSA-N C1NCCOC1 Chemical compound C1NCCOC1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4010/CHE/2014 | 2014-08-16 | ||
| IN4010CH2014 | 2014-08-16 | ||
| PCT/IN2014/000666 WO2016027275A1 (en) | 2014-08-16 | 2014-10-20 | Process for large scale production of n-[4-(1- cyclobutyl piperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acet amide dihydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170036044A KR20170036044A (ko) | 2017-03-31 |
| KR101860487B1 true KR101860487B1 (ko) | 2018-05-23 |
Family
ID=52339255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177005182A KR101860487B1 (ko) | 2014-08-16 | 2014-10-20 | N-[4-(1-시클로부틸 피페리딘-4-일옥시) 페닐]-2-(모르폴린-4-일) 아세트아미드 디히드로클로리드의 대규모 생산을 위한 방법 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9802896B2 (ja) |
| EP (1) | EP3180334B1 (ja) |
| JP (1) | JP6385580B2 (ja) |
| KR (1) | KR101860487B1 (ja) |
| CN (1) | CN106573925B (ja) |
| AP (1) | AP2017009753A0 (ja) |
| AU (1) | AU2014403999B2 (ja) |
| BR (1) | BR112017002922B1 (ja) |
| CA (1) | CA2957494C (ja) |
| CY (1) | CY1121253T1 (ja) |
| DK (1) | DK3180334T3 (ja) |
| EA (1) | EA032823B1 (ja) |
| ES (1) | ES2693378T3 (ja) |
| HK (1) | HK1231472A1 (ja) |
| HR (1) | HRP20181801T1 (ja) |
| HU (1) | HUE041465T2 (ja) |
| IL (1) | IL250412B (ja) |
| LT (1) | LT3180334T (ja) |
| MX (1) | MX364931B (ja) |
| NZ (1) | NZ728915A (ja) |
| PL (1) | PL3180334T3 (ja) |
| PT (1) | PT3180334T (ja) |
| RS (1) | RS57927B1 (ja) |
| SG (1) | SG11201701104SA (ja) |
| SI (1) | SI3180334T1 (ja) |
| TR (1) | TR201816175T4 (ja) |
| WO (1) | WO2016027275A1 (ja) |
| ZA (1) | ZA201700936B (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019229509A1 (en) * | 2018-05-31 | 2019-12-05 | Suven Life Sciences Limited | Method of treatment with histamine-3 receptor inverse agonist |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012114348A1 (en) * | 2011-02-23 | 2012-08-30 | Suven Life Sciences Limited | Novel compounds as histamine h3 receptor ligands |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
| CN103415510B (zh) * | 2011-02-04 | 2016-01-13 | 庵原化学工业株式会社 | 氨苯基嘧啶基醇衍生物的制备方法及其合成中间体 |
-
2014
- 2014-10-20 NZ NZ728915A patent/NZ728915A/en unknown
- 2014-10-20 WO PCT/IN2014/000666 patent/WO2016027275A1/en active Application Filing
- 2014-10-20 JP JP2017527992A patent/JP6385580B2/ja active Active
- 2014-10-20 TR TR2018/16175T patent/TR201816175T4/tr unknown
- 2014-10-20 EA EA201790388A patent/EA032823B1/ru unknown
- 2014-10-20 US US15/504,210 patent/US9802896B2/en active Active
- 2014-10-20 MX MX2017002043A patent/MX364931B/es active IP Right Grant
- 2014-10-20 CN CN201480081244.5A patent/CN106573925B/zh active Active
- 2014-10-20 SI SI201430937T patent/SI3180334T1/sl unknown
- 2014-10-20 CA CA2957494A patent/CA2957494C/en active Active
- 2014-10-20 BR BR112017002922-7A patent/BR112017002922B1/pt active IP Right Grant
- 2014-10-20 SG SG11201701104SA patent/SG11201701104SA/en unknown
- 2014-10-20 AU AU2014403999A patent/AU2014403999B2/en active Active
- 2014-10-20 LT LTEP14825190.3T patent/LT3180334T/lt unknown
- 2014-10-20 KR KR1020177005182A patent/KR101860487B1/ko active IP Right Grant
- 2014-10-20 RS RS20181306A patent/RS57927B1/sr unknown
- 2014-10-20 PT PT14825190T patent/PT3180334T/pt unknown
- 2014-10-20 EP EP14825190.3A patent/EP3180334B1/en active Active
- 2014-10-20 DK DK14825190.3T patent/DK3180334T3/en active
- 2014-10-20 PL PL14825190T patent/PL3180334T3/pl unknown
- 2014-10-20 ES ES14825190.3T patent/ES2693378T3/es active Active
- 2014-10-20 AP AP2017009753A patent/AP2017009753A0/en unknown
- 2014-10-20 HU HUE14825190A patent/HUE041465T2/hu unknown
-
2017
- 2017-02-02 IL IL25041217A patent/IL250412B/en active IP Right Grant
- 2017-02-07 ZA ZA2017/00936A patent/ZA201700936B/en unknown
- 2017-05-18 HK HK17105031.1A patent/HK1231472A1/zh unknown
-
2018
- 2018-10-30 CY CY20181101122T patent/CY1121253T1/el unknown
- 2018-10-30 HR HRP20181801TT patent/HRP20181801T1/hr unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012114348A1 (en) * | 2011-02-23 | 2012-08-30 | Suven Life Sciences Limited | Novel compounds as histamine h3 receptor ligands |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI454471B (zh) | 製備細胞凋亡促進劑之方法 | |
| JP2021035947A (ja) | ブルトンチロシンキナーゼ阻害剤の合成 | |
| EP3060551B1 (en) | Process for the preparation of a pde4 inhibitor | |
| EP2970263B1 (en) | Processes for the preparation of an apoptosis-inducing agent | |
| JP6151453B2 (ja) | １−［（２−ブロモフェニル）スルホニル］−５−メトキシ−３−［（４−メチル−１−ピペラジニル）メチル］−１ｈ−インドールジメシラート一水和物の大規模合成法 | |
| US11542245B2 (en) | Preparative process | |
| CN110799503A (zh) | 美卡奥美坎替的合成 | |
| JP6454707B2 (ja) | ｔｒａｎｓ−８−クロロ−５−メチル−１−［４−（ピリジン−２−イルオキシ）−シクロヘキシル］−５，６−ジヒドロ−４Ｈ−２，３，５，１０ｂ−テトラアザ−ベンゾ［ｅ］アズレン及びその結晶形態の合成 | |
| WO2012004391A1 (en) | Process for the preparation of flupirtine maleate | |
| KR101860487B1 (ko) | N-[4-(1-시클로부틸 피페리딘-4-일옥시) 페닐]-2-(모르폴린-4-일) 아세트아미드 디히드로클로리드의 대규모 생산을 위한 방법 | |
| TWI534126B (zh) | 用於製備吡唑羧酸醯胺之方法 | |
| KR101085170B1 (ko) | (ｓ)-리바스티그민의 제조방법 | |
| CN108033902A (zh) | 一种高纯度贝利司他顺式异构体的制备方法 | |
| CN105712920B (zh) | 一种维格列汀的制备方法 | |
| NO311935B1 (no) | Nye heteroaryloksyetylaminer, anvendelse, fremgangsmåte for fremstilling derav og farmasöytiske preparater inneholdende dem | |
| CN115650935A (zh) | 一种高哌嗪衍生物的高纯制备方法 | |
| CN116217522A (zh) | Glp-1受体激动剂关键中间体的手性纯化方法 | |
| JPH0119378B2 (ja) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant |