KR101826531B1 - 약물 저항성 미생물 치료를 위한 메틸설포닐메탄 - Google Patents

약물 저항성 미생물 치료를 위한 메틸설포닐메탄 Download PDF

Info

Publication number
KR101826531B1
KR101826531B1 KR1020127013999A KR20127013999A KR101826531B1 KR 101826531 B1 KR101826531 B1 KR 101826531B1 KR 1020127013999 A KR1020127013999 A KR 1020127013999A KR 20127013999 A KR20127013999 A KR 20127013999A KR 101826531 B1 KR101826531 B1 KR 101826531B1
Authority
KR
South Korea
Prior art keywords
msm
staphylococcus aureus
oxacillin
resistant
pathogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020127013999A
Other languages
English (en)
Korean (ko)
Other versions
KR20120107951A (ko
Inventor
로드니 벤자민
제프리 바렐만
안쏘니 켈러
Original Assignee
바이오제닉 이노베이션스 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이오제닉 이노베이션스 엘엘씨 filed Critical 바이오제닉 이노베이션스 엘엘씨
Publication of KR20120107951A publication Critical patent/KR20120107951A/ko
Application granted granted Critical
Publication of KR101826531B1 publication Critical patent/KR101826531B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/10—Sulfones; Sulfoxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127013999A 2009-10-30 2010-10-29 약물 저항성 미생물 치료를 위한 메틸설포닐메탄 Expired - Fee Related KR101826531B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US25693509P 2009-10-30 2009-10-30
US61/256,935 2009-10-30
US25775109P 2009-11-03 2009-11-03
US61/257,751 2009-11-03
US25909809P 2009-11-06 2009-11-06
US61/259,098 2009-11-06
US29443710P 2010-01-12 2010-01-12
US61/294,437 2010-01-12
PCT/US2010/054837 WO2011053848A1 (en) 2009-10-30 2010-10-29 Methylsulfonylmethane (msm) for treatment of drug resistant microorganisms

Publications (2)

Publication Number Publication Date
KR20120107951A KR20120107951A (ko) 2012-10-04
KR101826531B1 true KR101826531B1 (ko) 2018-02-07

Family

ID=43922597

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020127013999A Expired - Fee Related KR101826531B1 (ko) 2009-10-30 2010-10-29 약물 저항성 미생물 치료를 위한 메틸설포닐메탄
KR1020127014002A Expired - Fee Related KR101763560B1 (ko) 2009-10-30 2010-10-29 미생물 활성을 조절하기 위한 메틸술포닐메탄의 이용

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020127014002A Expired - Fee Related KR101763560B1 (ko) 2009-10-30 2010-10-29 미생물 활성을 조절하기 위한 메틸술포닐메탄의 이용

Country Status (15)

Country Link
US (7) US20110105623A1 (cg-RX-API-DMAC7.html)
EP (2) EP2494059B1 (cg-RX-API-DMAC7.html)
JP (2) JP2013509197A (cg-RX-API-DMAC7.html)
KR (2) KR101826531B1 (cg-RX-API-DMAC7.html)
CN (2) CN102724973B (cg-RX-API-DMAC7.html)
AU (2) AU2010313228B2 (cg-RX-API-DMAC7.html)
BR (2) BR112012010272A2 (cg-RX-API-DMAC7.html)
CA (2) CA2778142C (cg-RX-API-DMAC7.html)
DK (2) DK2494059T3 (cg-RX-API-DMAC7.html)
ES (2) ES2674019T3 (cg-RX-API-DMAC7.html)
IL (2) IL219321A (cg-RX-API-DMAC7.html)
MX (3) MX367373B (cg-RX-API-DMAC7.html)
NZ (2) NZ600145A (cg-RX-API-DMAC7.html)
SG (1) SG10201500283UA (cg-RX-API-DMAC7.html)
WO (2) WO2011053854A1 (cg-RX-API-DMAC7.html)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007033082A2 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (dmso)
US8435224B2 (en) 2005-09-12 2013-05-07 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
AU2006291134C1 (en) 2005-09-12 2013-08-15 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same
BRPI0921494A2 (pt) * 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
US9839609B2 (en) 2009-10-30 2017-12-12 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis
AU2010313228B2 (en) 2009-10-30 2014-05-29 Biogenic Innovations, Llc Methylsulfonylmethane (MSM) for treatment of drug resistant microorganisms
WO2011123695A1 (en) * 2010-03-31 2011-10-06 Abela Pharmaceuticals, Inc. Dimethy sulfoxxide (dmso) formulations for treating autism
WO2012122457A2 (en) * 2011-03-09 2012-09-13 Baum Marc Michael Keratin-based hair straightening formulations, methods and systems
RU2446815C1 (ru) * 2011-03-03 2012-04-10 Общество С Ограниченной Ответственностью "Парафарм" Биологически активная добавка к пище для нормализации функции щитовидной железы
US9114902B2 (en) 2011-03-22 2015-08-25 Polyone Designed Structures And Solutions Llc Methods and systems for use in forming an article from a multi-layer sheet structure
US9446089B1 (en) 2011-09-20 2016-09-20 Aja Henderson Oil blend for skin treatment
US8932656B1 (en) 2011-09-20 2015-01-13 Aja Henderson Oil blend for skin treatment
US9717757B1 (en) 2011-12-28 2017-08-01 Samuel N. Gasque, Jr. Composition and method to treat and prevent muscle cramping
US11931393B2 (en) * 2012-04-10 2024-03-19 Parapharm Llc Biologically active food additive for normalizing the function of the thyroid gland
KR101381794B1 (ko) * 2012-04-10 2014-04-07 씨제이제일제당 (주) 타가토스 및 프로바이오틱 유산균을 함유하는 신바이오틱 식품 조성물
RU2525426C2 (ru) * 2012-07-16 2014-08-10 Государственное научное учреждение Научно-исследовательский ветеринарный институт Нечерноземной зоны Российской Федерации Российской академии сельскохозяйственных наук Способ коррекции вторичных иммунодефицитов у телят
RU2694758C2 (ru) * 2012-12-20 2019-07-16 Раджив Бхушан Антимикробные композиции
KR101460777B1 (ko) 2013-03-04 2014-11-19 주식회사 씨앤피코스메틱스 여드름 개선용 화장료 조성물
US9484589B1 (en) * 2013-08-13 2016-11-01 The United States Of America As Represented By Secretary Of The Navy Microbial fuel cell with sediment agitator
CN103435151B (zh) * 2013-08-20 2014-10-08 珠海市德莱环保科技有限公司 提高废水好氧微生物降解cod能力的生物增强剂及方法
GB2521632B (en) * 2013-12-23 2020-12-16 Linscott Goode Steven Vermin control compositions
US20150328139A1 (en) * 2014-05-15 2015-11-19 Keith Marz Orally Ingested or Topically Applied Skin Health and Nutrition Product
US10766799B2 (en) * 2014-05-23 2020-09-08 Nch Corporation Method for improving quality of aquaculture pond water using a nutrient germinant composition and spore incubation method
MX382504B (es) 2014-09-30 2025-03-13 Kimberly Clark Co Papel tisu crepado prebiotico.
BR112017004630B1 (pt) 2014-09-30 2023-04-11 Kimberly-Clark Worldwide, Inc Formulação prebiótica sinérgica, lenço prebiótico, e, lenço umedecido prebiótico
EP3286731B1 (en) * 2015-04-23 2020-09-16 BD Kiestra B.V. Colony contrast gathering
WO2016210074A1 (en) * 2015-06-23 2016-12-29 Carrie D. Alspaugh, M.D., P.A. Hand sanitizing compositions
RU2577816C1 (ru) * 2015-07-10 2016-03-20 Олег Иванович Квасенков Способ получения хлебного кваса
RU2577973C1 (ru) * 2015-07-13 2016-03-20 Олег Иванович Квасенков Способ получения хлебного кваса
RU2590148C1 (ru) * 2015-07-14 2016-07-10 Олег Иванович Квасенков Способ получения хлебного кваса
RU2590147C1 (ru) * 2015-07-14 2016-07-10 Олег Иванович Квасенков Способ получения хлебного кваса
RU2590146C1 (ru) * 2015-07-14 2016-07-10 Олег Иванович Квасенков Способ получения хлебного кваса
US20170156289A1 (en) * 2015-12-04 2017-06-08 Woojo Chung Gait Helper
US10327480B2 (en) * 2015-12-21 2019-06-25 Misbah Khan Disposable liners for body areas
KR101948772B1 (ko) * 2016-01-26 2019-05-10 김양희 표고버섯 재배 방법
WO2017173240A1 (en) 2016-03-31 2017-10-05 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
EP3436041B1 (en) 2016-03-31 2023-05-24 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
AU2017240064B8 (en) 2016-03-31 2021-11-11 Gojo Industries, Inc. Antimicrobial peptide stimulating sanitizing composition
US10897922B2 (en) 2016-04-05 2021-01-26 Nch Corporation Composition and method for germinative compounds in probiotic food and beverage products for human consumption
US12097226B2 (en) 2016-04-05 2024-09-24 Nch Corporation System and method for using a single-serve nutrient spore composition for small scale farm applications
CA3019732A1 (en) 2016-04-05 2017-10-12 Nch Corporation Nutrient rich germinant composition and spore incubation method
ITUA20162680A1 (it) * 2016-04-18 2017-10-18 Univ Degli Studi Cagliari Composti sulfamidici e/o tiosolfonici anti-batterici per l’utilizzo nel trattamento del virus herpes 8 in fase latente
WO2017195173A1 (en) 2016-05-12 2017-11-16 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
US10076551B2 (en) 2016-11-14 2018-09-18 FREDRICK COBBLE, Jr. Method for treating interstitial lung disease
JP2020500860A (ja) 2016-11-23 2020-01-16 ゴジョ・インダストリーズ・インコーポレイテッド プロバイオティック／プレバイオティックな有効成分を含む消毒薬組成物
KR101878599B1 (ko) * 2017-03-28 2018-07-13 전북대학교산학협력단 메틸설포닐메테인과 만니톨의 흡수촉진 및 고미감소를 위한 공침조성물과 이의 제조방법
CA3058394A1 (en) 2017-03-28 2018-10-04 Verdesian Life Sciences U.S., Llc Triarylmethane compounds for controlling enzyme-induced urea decomposition
EP3618931B1 (en) * 2017-05-17 2023-03-29 Colgate-Palmolive Company Oral care compositions and methods of use
US20180333349A1 (en) 2017-05-17 2018-11-22 Colgate-Palmolive Company Oral Care Compositions and Methods of Use
KR102065848B1 (ko) * 2017-07-05 2020-01-13 고려대학교 산학협력단 엔테로코코스 카니테스티니(Enterococcus canintestini)균주를 함유하는 항인플루엔자 바이러스 조성물
US10238103B2 (en) * 2017-08-08 2019-03-26 Valent Biosciences Llc Rhizobia and mycorrhizal granular formulations and mixtures thereof
EA202090556A1 (ru) * 2017-09-21 2020-07-10 Сами Лабс Лимитед Композиция алкогольного напитка, содержащая bacillus coagulans
WO2019104249A1 (en) * 2017-11-22 2019-05-31 Progeneron Topical compositions, process of manufacture and method of use
US11564963B2 (en) 2017-11-22 2023-01-31 Progeneron, Llc Topical compositions, process of large-scale manufacture, and method of use
CN107937290B (zh) * 2017-12-15 2021-01-19 北京工商大学 一株用于水果采后病害防治的拜耳接合酵母及其制备方法与用途
KR102050286B1 (ko) * 2018-02-08 2019-12-02 전북대학교산학협력단 건강기능식품 및 이의 제조방법
US10792320B2 (en) * 2018-03-28 2020-10-06 Michael Alan Beller Methods for treatment of bladder dysfunction
CN108342324A (zh) * 2018-04-10 2018-07-31 中盐工程技术研究院有限公司 一种小球藻保存方法
CN108707568A (zh) * 2018-06-13 2018-10-26 河北康泰药业有限公司 一种混合益生菌的发酵生产方法
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
SG11202101255UA (en) 2018-08-09 2021-03-30 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
WO2020041193A1 (en) * 2018-08-20 2020-02-27 Ian Mitchell Lipofullerene conjugates and their use for promotion of hair growth and prevention of hair loss
CN111265502B (zh) * 2018-12-05 2022-05-20 中国医学科学院药物研究所 香紫苏醇和香紫苏内酯在抗丝状病毒感染中的应用
WO2020210784A1 (en) 2019-04-12 2020-10-15 Ecolab Usa Inc. Antimicrobial multi-purpose cleaner and methods of making and using the same
CN110172420B (zh) * 2019-05-15 2022-03-01 福建省农业科学院农业工程技术研究所 一株鼠李糖乳杆菌及其应用
WO2020237244A1 (en) * 2019-05-23 2020-11-26 Professional Compounding Centers Of America, Inc. Skin permeation enhancing composition
US20220386643A1 (en) * 2019-10-29 2022-12-08 Fuji Oil Holdings Inc. Cocoa substitute
RU2723907C1 (ru) * 2019-12-27 2020-06-18 Сергей Александрович Савчук Способ идентификации наркотических и психоактивных веществ в биосубстрате человека
WO2021159068A1 (en) 2020-02-06 2021-08-12 Nch Corportion Composition and method of using germinative compounds in probiotics for inflammation reduction in humans
AU2021254780A1 (en) * 2020-04-16 2022-10-20 Atossa Therapeutics, Inc. Compositions and methods to reduce the infectivity of a virus
KR20220000029A (ko) 2020-06-24 2022-01-03 주식회사 해피마스타 면역력 증강을 위한 건강 기능 식품 및 그 조성물
CN112098384B (zh) * 2020-09-22 2023-09-01 华东交通大学 一种快速预测水质是否生物稳定的简捷方法
CN112237551A (zh) * 2020-11-13 2021-01-19 深圳市薇美经典科技发展有限公司 一种修复护肤制剂制备方法
CN112220966A (zh) * 2020-11-23 2021-01-15 北京大学口腔医学院 一种注射剂、注射剂的制备方法及其在牙髓再生中的应用
CN112516117A (zh) * 2020-11-30 2021-03-19 中国人民解放军陆军特色医学中心 Msm在制备破坏细胞壁及脏器保护药物中的应用
IN202041055641A (cg-RX-API-DMAC7.html) * 2020-12-21 2021-11-19
CN113009051A (zh) * 2021-02-22 2021-06-22 中国食品药品检定研究院 肠道病毒71型灭活疫苗中β-内酰胺类抗生素的检测方法
CN113057933A (zh) * 2021-04-04 2021-07-02 山西医科大学 一种维护和重塑皮肤微生态的润肤剂及制备方法
US20220362126A1 (en) * 2021-05-13 2022-11-17 Mark A. Foglietti Cosmetic composition and method
US20230058302A1 (en) * 2021-08-03 2023-02-23 Purina Animal Nutrition Llc Products and methods for inhibiting respiratory conditions
CN114480167B (zh) * 2021-12-23 2024-01-12 美益添生物医药(武汉)有限公司 乳酸乳球菌md-622及其应用
US20260015574A1 (en) * 2022-02-16 2026-01-15 Yeda Research And Development Co. Ltd. Methods for shortening lag phase duration in microorganisms
CN114965766B (zh) * 2022-05-20 2024-03-08 重庆市食品药品检验检测研究院 豆瓣酱中有害污染源的评估方法
CN114794029B (zh) * 2022-06-09 2023-02-28 上海大学 一种计数秀丽隐杆线虫子宫内发育胚胎数目的方法
CN115517166B (zh) * 2022-10-21 2023-10-10 玉溪中烟种子有限责任公司 一种高活力液体负载复合花粉的制备及授粉应用方法
CN116287069B (zh) * 2023-02-15 2026-02-17 河北农业大学 一种微生物发酵核桃粕制备核桃肽的方法及核桃肽
CN117363529A (zh) * 2023-06-27 2024-01-09 深圳市波尔顿科技有限公司 具有肠炎治疗作用的鼠李糖乳杆菌及其应用
CN117126906B (zh) * 2023-07-13 2024-10-25 中国农业大学 大豆分离蛋白的改性方法、改性大豆分离蛋白及其应用
WO2025205045A1 (ja) * 2024-03-29 2025-10-02 マイキャン・テクノロジーズ株式会社 ウイルス易感染性細胞の製造方法
CN118333240B (zh) * 2024-06-12 2024-08-27 吉林农业大学 一种尿囊素参与下的大豆产量的预测方法
CN118374413B (zh) * 2024-06-21 2024-09-13 青岛诺和诺康生物科技有限公司 一株减少口腔病原菌致病性的唾液联合乳杆菌nhnk-612及其制品和应用
US12605417B2 (en) 2024-09-27 2026-04-21 Codex Labs Corporation Compositions and methods for ameliorating symptoms associated with inflammatory skin disorders
CN119875925B (zh) * 2025-01-21 2025-10-03 浙江工业大学 一株具有羟苯甲酮降解能力的嗜麦芽窄食单胞菌及其应用
CN119912274B (zh) * 2025-04-07 2025-06-27 成都贝雅医疗科技有限公司 一种表面包覆改性的磷酸钙微球及其制备方法
CN120535353A (zh) * 2025-05-30 2025-08-26 商洛学院 一种葡萄专用富有机硒肥料及其制备方法和应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654165A (en) * 1970-09-10 1972-04-04 Stanley Charles Bryant Telephone cleaner-sanitizer
US4333922A (en) * 1974-09-12 1982-06-08 Herschler R J Method for the treatment of water-living animals with health modifying agents
US4296130A (en) * 1979-08-30 1981-10-20 Herschler R J Methylsulfonylmethane and methods of use
US4514421A (en) * 1979-08-30 1985-04-30 Herschler R J Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it
US4568547A (en) * 1979-08-30 1986-02-04 Herschler R J Solid pharmaceutical compositions comprising MSM and their production
US4914135A (en) * 1979-08-30 1990-04-03 Herschler R J Use of Methylsulfonylmethane to treat parasitic infections
US4973605A (en) * 1979-08-30 1990-11-27 Herschler R J Use of methylsulfonylmethane to relieve pain and relieve pain and nocturnal cramps and to reduce stress-induced deaths in animals
US4559329A (en) * 1982-09-14 1985-12-17 Herschler R J Dietary and pharmaceutical uses of methyl-sulfonylmethane and compositions comprising it
US5071878A (en) * 1979-08-30 1991-12-10 Herschler R J Use of methylsulfonylmethane to enhance diet of an animal
US4477469A (en) * 1979-08-30 1984-10-16 Herschler R J Preparations containing methylsulfonylmethane and methods of use and purification
US4863748A (en) * 1979-08-30 1989-09-05 Herschler R J Dietary products and uses comprising methylsulfonylmethane
US4616039A (en) * 1979-08-30 1986-10-07 Herschler R J Methylsulfonylmethane in dietary products
JPH0740911B2 (ja) * 1986-07-31 1995-05-10 麒麟麦酒株式会社 酵母入りビ−ル
US4902517A (en) * 1987-12-28 1990-02-20 The Calpis Food Industry Co., Ltd. Processes for producing milk-derived alcoholic beverages
AU4974793A (en) 1992-09-04 1994-03-29 Aws Shakir Mustafa Salim Skin treatment compositions containing dimethylsulphone and dimethylsulphoxide
CN1069192C (zh) * 1994-04-21 2001-08-08 王世立 一种气溶胶制剂及其配制方法
WO1995029897A1 (en) * 1994-04-29 1995-11-09 G.D. Searle & Co. METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS
US5753696A (en) * 1996-12-12 1998-05-19 Cluster Technology Corp. Compositions and methods for enhancement of dehydroepiandrosterone
DE19735120A1 (de) * 1997-08-13 1999-02-18 Peter Hans Prof D Hofschneider Verwendung von Thiolverbindungen zur Inaktivierung von Viren
US6183758B1 (en) * 1998-01-29 2001-02-06 Highland Laboratories, Inc. Phytochemicals, nutrients & medication absorption &/or treatment
EP1212093B1 (en) * 1999-08-26 2004-07-07 Ganeden Biotech, Inc. Use of emu oil as a carrier for antifungal, antibacterial and antiviral medications
WO2001073096A1 (en) * 2000-03-28 2001-10-04 Cubist Pharmaceuticals, Inc. Enhanced production of secondary metabolites in the presence of organic additives
CN1282577A (zh) * 2000-05-31 2001-02-07 陈小川 二甲基亚砜在提高各类抗生素对细菌的敏感性等方面用途
US6440391B1 (en) * 2000-06-02 2002-08-27 Elstan Corporation Management of snoring by oral administration of dimethyl sulfone
GB2368012A (en) * 2000-10-19 2002-04-24 Nicholas John Larkins Preparation for the relief of inflammatory disease
US6328987B1 (en) * 2000-11-03 2001-12-11 Jan Marini Skin Research, Inc. Cosmetic skin care compositions containing alpha interferon
US6416772B1 (en) * 2001-01-12 2002-07-09 H. Wayne Van Engelen Topical dermal anaesthetic
JP3895224B2 (ja) * 2001-12-03 2007-03-22 東京応化工業株式会社 ポジ型レジスト組成物及びそれを用いたレジストパターン形成方法
US6579543B1 (en) * 2002-02-22 2003-06-17 Jackie H. McClung Composition for topical application to skin
US20040001817A1 (en) * 2002-05-14 2004-01-01 Giampapa Vincent C. Anti-aging nutritional supplement
GB0212622D0 (en) * 2002-05-31 2002-07-10 Natural Technologies Group Ltd Bacterial transforming agent
US6776979B2 (en) * 2002-12-30 2004-08-17 Marvin B. Frager Periodontal treatment compound and method of use
ATE513551T1 (de) * 2003-01-24 2011-07-15 Flora Technology Inc Zusammensetzungen und verfahren zur wiederherstellung der bakterienflora
US7572473B2 (en) * 2003-02-19 2009-08-11 Franklin Foods, Inc. Process for making yogurt cream cheese, and the resulting products
US20040229825A1 (en) 2003-05-13 2004-11-18 Tomihiko Higuchi Pharmaceutical composition for treatment of infection with drug resistant bacterium and disinfectant
US20050118291A1 (en) * 2003-09-10 2005-06-02 Mian-Ying Wang Formulations and methods for treating breast cancer with Morinda citrifolia and methylsulfonymethane
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
ITBS20040068A1 (it) * 2004-05-24 2004-08-24 Gen Topics Srl Composizione cosmetica e/o farmaceutica per il trattamento della rosacea
US20060084573A1 (en) * 2004-10-12 2006-04-20 Biagro Western Sales, Inc. High calcium fertilizer composition
EP1906754A4 (en) * 2005-05-31 2009-03-11 Limited Wockhardt NEW ADDITIVES FOR POULTRY AND ANIMALS
US20070021376A1 (en) * 2005-07-21 2007-01-25 Suracell, Inc. Supplement composition and method of use in enhancement of methylation process
US8435224B2 (en) * 2005-09-12 2013-05-07 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
US9265792B2 (en) * 2005-11-16 2016-02-23 Patricia A. Riley Integument cell regeneration formulation
WO2007134294A2 (en) * 2006-05-12 2007-11-22 Arizona Board Of Regents, A Body Corporate Of The State Of Az Acting For & On Behalf Of Az State Unviversity Novel chlorella species and uses therefor
US20080038219A1 (en) * 2006-08-07 2008-02-14 Calgenex Corporation Novel Composition for a Topical Skin Treatment Base and Medicated Applications Thereof
US20080260708A1 (en) * 2007-04-19 2008-10-23 Hall Mickey A Methods and related systems and formulations to normalize and improve human body chemistry and healing ability
US7960098B2 (en) * 2007-07-12 2011-06-14 Warsaw Orthoperic, Inc. Methods and compositions for the preservation of cells and tissues
US7892724B2 (en) * 2007-07-12 2011-02-22 Warsaw Orthopedic, Inc Method for enhancing the viability of mammalian cells, tissues and organs using a solution comprising two low molecular weight PEGs
AP2011006001A0 (en) * 2009-04-30 2011-12-31 Bakteriefritt As Composition for sterilizing surfaces.
IT1393712B1 (it) * 2009-05-13 2012-05-08 Bruschettini Srl Composizioni oftalmiche per la riepitelizzazione, la cicatrizzazione, e la disinfezione dei tessuti oculari
AU2010313228B2 (en) * 2009-10-30 2014-05-29 Biogenic Innovations, Llc Methylsulfonylmethane (MSM) for treatment of drug resistant microorganisms

Also Published As

Publication number Publication date
US20120149672A1 (en) 2012-06-14
US20130065967A9 (en) 2013-03-14
KR20120107951A (ko) 2012-10-04
ES2674019T3 (es) 2018-06-26
US20110136210A1 (en) 2011-06-09
JP5651186B2 (ja) 2015-01-07
KR101763560B1 (ko) 2017-08-01
CA2778144A1 (en) 2011-05-05
CA2778144C (en) 2020-04-21
JP2013509437A (ja) 2013-03-14
ES2616630T3 (es) 2017-06-13
CA2778142A1 (en) 2011-05-05
IL219320A (en) 2016-02-29
WO2011053854A1 (en) 2011-05-05
NZ600134A (en) 2014-08-29
EP2493464A1 (en) 2012-09-05
CN102724973B (zh) 2014-08-27
KR20140015146A (ko) 2014-02-06
US20130338130A1 (en) 2013-12-19
CN102834520B (zh) 2016-05-25
US20140349375A1 (en) 2014-11-27
MX367373B (es) 2019-08-01
CA2778142C (en) 2018-04-24
EP2493464B1 (en) 2018-04-18
AU2010281739A1 (en) 2011-05-26
BR112012010270A2 (pt) 2016-11-29
US8841100B2 (en) 2014-09-23
AU2010313228B2 (en) 2014-05-29
CN102834520A (zh) 2012-12-19
WO2011053848A1 (en) 2011-05-05
BR112012010272A2 (pt) 2019-10-01
DK2494059T3 (en) 2017-02-20
EP2494059A1 (en) 2012-09-05
MX353059B (es) 2017-12-13
EP2493464B8 (en) 2018-06-27
EP2494059A4 (en) 2013-12-04
AU2010281739B2 (en) 2011-06-09
SG10201500283UA (en) 2015-03-30
US20110152231A1 (en) 2011-06-23
MX2012005159A (es) 2012-08-03
NZ600145A (en) 2013-12-20
US8217085B2 (en) 2012-07-10
JP2013509197A (ja) 2013-03-14
IL219321A0 (en) 2012-06-28
US20110105623A1 (en) 2011-05-05
US20120220667A1 (en) 2012-08-30
IL219320A0 (en) 2012-06-28
EP2493464A4 (en) 2013-04-24
EP2494059B1 (en) 2016-11-23
US9487749B2 (en) 2016-11-08
IL219321A (en) 2017-06-29
CN102724973A (zh) 2012-10-10
DK2493464T3 (en) 2018-06-18
AU2010313228A1 (en) 2012-06-14

Similar Documents

Publication Publication Date Title
KR101826531B1 (ko) 약물 저항성 미생물 치료를 위한 메틸설포닐메탄
Zhang et al. Quantitative proteomics reveals the mechanism of silver nanoparticles against multidrug-resistant Pseudomonas aeruginosa biofilms
Zemke et al. Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells
US20230149518A1 (en) Compositions and methods for disrupting biofilm formation and maintenance
Zhao et al. Can we arrest the evolution of antibiotic resistance? The differences between the effects of silver nanoparticles and silver ions
US9913862B2 (en) Methods of treating gram-negative microbial infections
King et al. Pseudomonas aeruginosa in the cystic fibrosis lung
HK1174849B (en) Methylsulfonylmethane (msm) for treatment of drug resistant microorganisms
CN103396471B (zh) 一种金属β-内酰胺酶抑制肽及其应用
Ahmed et al. Early Therapeutic Nutrition: A key strategy for preventing sepsis in critically ill patients
HK40110019A (zh) 处理细菌细胞群体的方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

X091 Application refused [patent]
AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PX0901 Re-examination

St.27 status event code: A-2-3-E10-E12-rex-PX0901

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PX0701 Decision of registration after re-examination

St.27 status event code: A-3-4-F10-F13-rex-PX0701

X701 Decision to grant (after re-examination)
GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20210202

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20210202