KR101807323B1 - Tnfr2에 대한 천연 안티센스 전사체의 억제에 의한 종양 괴사 인자 수용체 2(tnfr2) 관련된 질환의 치료 - Google Patents
Tnfr2에 대한 천연 안티센스 전사체의 억제에 의한 종양 괴사 인자 수용체 2(tnfr2) 관련된 질환의 치료 Download PDFInfo
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- KR101807323B1 KR101807323B1 KR1020127001135A KR20127001135A KR101807323B1 KR 101807323 B1 KR101807323 B1 KR 101807323B1 KR 1020127001135 A KR1020127001135 A KR 1020127001135A KR 20127001135 A KR20127001135 A KR 20127001135A KR 101807323 B1 KR101807323 B1 KR 101807323B1
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- oligonucleotide
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21991109P | 2009-06-24 | 2009-06-24 | |
| US61/219,911 | 2009-06-24 | ||
| PCT/US2010/039824 WO2010151671A2 (en) | 2009-06-24 | 2010-06-24 | Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20120029474A KR20120029474A (ko) | 2012-03-26 |
| KR101807323B1 true KR101807323B1 (ko) | 2017-12-08 |
Family
ID=43387126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127001135A Expired - Fee Related KR101807323B1 (ko) | 2009-06-24 | 2010-06-24 | Tnfr2에 대한 천연 안티센스 전사체의 억제에 의한 종양 괴사 인자 수용체 2(tnfr2) 관련된 질환의 치료 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8859515B2 (enExample) |
| EP (1) | EP2446036B1 (enExample) |
| JP (1) | JP6073133B2 (enExample) |
| KR (1) | KR101807323B1 (enExample) |
| CN (1) | CN102597238B (enExample) |
| CA (1) | CA2765889A1 (enExample) |
| ES (1) | ES2618894T3 (enExample) |
| WO (1) | WO2010151671A2 (enExample) |
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| JP5959795B2 (ja) | 2006-08-18 | 2016-08-02 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | 血液脳関門送達のための物質 |
| EP2182980A4 (en) | 2007-07-27 | 2012-04-18 | Armagen Technologies Inc | METHOD AND COMPOSITIONS FOR INCREASED ALPHA IDURONIDASE ACTIVITY IN THE CNS |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| CA2748889A1 (en) | 2009-03-18 | 2010-09-23 | Armagen Technologies, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| HRP20190690T1 (hr) | 2009-10-09 | 2019-06-28 | Armagen, Inc. | Postupci i pripravci za povećanje aktiviteta iduronat-2-sulfataze u centralnom nervnom sustavu |
| EP3260540A1 (en) | 2010-11-12 | 2017-12-27 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| EP2785378B1 (en) | 2011-12-02 | 2020-05-13 | Armagen, Inc. | Methods and compositions for increasing arylsulfatase a activity in the cns |
| DK2850189T3 (en) | 2012-05-16 | 2019-02-25 | Translate Bio Ma Inc | COMPOSITIONS AND PROCEDURES FOR MODULATING GENEPRESSION |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| DK2850186T3 (en) | 2012-05-16 | 2019-04-08 | Translate Bio Ma Inc | COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION |
| EP2850182A4 (en) | 2012-05-16 | 2016-01-20 | Rana Therapeutics Inc | COMPOSITIONS AND METHODS FOR MODULATING ATP2A2 GENE EXPRESSION |
| CA2873769A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating hemoglobin gene family expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| KR20160074368A (ko) | 2012-05-16 | 2016-06-28 | 라나 테라퓨틱스, 인크. | Utrn 발현을 조절하기 위한 조성물 및 방법 |
| AU2014241162A1 (en) | 2013-03-27 | 2015-10-22 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways |
| WO2015009961A1 (en) * | 2013-07-19 | 2015-01-22 | Armagen Technologies, Inc. | Compositions and methods related to structures that cross the blood brain barrier |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| CA2966044A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
| AU2016226415B2 (en) * | 2015-03-02 | 2021-09-09 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using a TNF receptor 2 antagonist |
| EP3271460A4 (en) | 2015-03-17 | 2019-03-13 | The General Hospital Corporation | RNA INTERACTOM OF POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) |
| WO2017070076A1 (en) * | 2015-10-20 | 2017-04-27 | Albert Einstein College Of Medicine, Inc. | Therapeutic tnfr-1b targets and uses thereof |
| CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
| WO2018195328A1 (en) * | 2017-04-20 | 2018-10-25 | Cedars-Sinai Medical Center | Methods of predicting non-response to anti-tnf treatment in subjects with inflammatory bowel disease |
| CN107541499B (zh) * | 2017-07-27 | 2020-04-14 | 山东兴瑞生物科技有限公司 | 一种靶向免疫检测点tnfr2的cik的制备及其应用 |
| CN110478485B (zh) * | 2019-08-13 | 2022-01-18 | 复旦大学附属华山医院 | Asb3在制备治疗非酒精性脂肪性肝病药物中的应用 |
| JP7356650B2 (ja) * | 2019-11-05 | 2023-10-05 | 日本電気株式会社 | ヒトt細胞白血病ウイルス1型(htlv-1)関連疾患の診断方法 |
| CA3186629A1 (en) * | 2020-07-22 | 2022-01-27 | The Florey Institute Of Neuroscience And Mental Health | Compositions and methods for treating disorders associated with loss-of-function mutations in scn2a |
| CN116492464B (zh) * | 2023-04-12 | 2025-08-19 | 天津医科大学总医院 | TNFRSF1A抑制剂miR-3059-5p在治疗脑卒中疾病中的用途 |
| CN119241620B (zh) * | 2024-12-03 | 2025-04-08 | 羿美诚健(上海)生物医药有限公司 | 一种双链siRNA及其制备方法,药物组合物和用途 |
Citations (1)
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| US20070248590A1 (en) * | 2005-12-02 | 2007-10-25 | Sirtris Pharmaceuticals, Inc. | Modulators of CDC2-like kinases (CLKS) and methods of use thereof |
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| WO2008066672A2 (en) | 2006-11-06 | 2008-06-05 | Beth Israel Deaconess Medical Center | Identification and use of small molecules to modulate transcription factor function and to treat transcription factor associated diseases |
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| AU2008308499A1 (en) * | 2007-10-04 | 2009-04-09 | Board Of Regents, The University Of Texas System | Modulating gene expression with agRNA and gapmers targeting antisense transcripts |
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2010
- 2010-06-24 CA CA2765889A patent/CA2765889A1/en active Pending
- 2010-06-24 US US13/379,728 patent/US8859515B2/en active Active
- 2010-06-24 JP JP2012517730A patent/JP6073133B2/ja not_active Expired - Fee Related
- 2010-06-24 CN CN201080038294.7A patent/CN102597238B/zh not_active Expired - Fee Related
- 2010-06-24 WO PCT/US2010/039824 patent/WO2010151671A2/en not_active Ceased
- 2010-06-24 ES ES10792665.1T patent/ES2618894T3/es active Active
- 2010-06-24 EP EP10792665.1A patent/EP2446036B1/en not_active Not-in-force
- 2010-06-24 KR KR1020127001135A patent/KR101807323B1/ko not_active Expired - Fee Related
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2014
- 2014-09-04 US US14/477,457 patent/US9771593B2/en not_active Expired - Fee Related
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| US20070248590A1 (en) * | 2005-12-02 | 2007-10-25 | Sirtris Pharmaceuticals, Inc. | Modulators of CDC2-like kinases (CLKS) and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2618894T3 (es) | 2017-06-22 |
| KR20120029474A (ko) | 2012-03-26 |
| WO2010151671A2 (en) | 2010-12-29 |
| US8859515B2 (en) | 2014-10-14 |
| US9771593B2 (en) | 2017-09-26 |
| JP2012531204A (ja) | 2012-12-10 |
| CA2765889A1 (en) | 2010-12-29 |
| EP2446036A4 (en) | 2013-09-18 |
| US20120094934A1 (en) | 2012-04-19 |
| WO2010151671A3 (en) | 2011-07-21 |
| CN102597238B (zh) | 2016-06-29 |
| US20140371301A1 (en) | 2014-12-18 |
| JP6073133B2 (ja) | 2017-02-01 |
| CN102597238A (zh) | 2012-07-18 |
| EP2446036B1 (en) | 2017-03-01 |
| EP2446036A2 (en) | 2012-05-02 |
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