KR101708065B1 - 지방산 아세틸화 살리실레이트 및 그 용도 - Google Patents
지방산 아세틸화 살리실레이트 및 그 용도 Download PDFInfo
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- KR101708065B1 KR101708065B1 KR1020117002838A KR20117002838A KR101708065B1 KR 101708065 B1 KR101708065 B1 KR 101708065B1 KR 1020117002838 A KR1020117002838 A KR 1020117002838A KR 20117002838 A KR20117002838 A KR 20117002838A KR 101708065 B1 KR101708065 B1 KR 101708065B1
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- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/609—Amides, e.g. salicylamide
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7898308P | 2008-07-08 | 2008-07-08 | |
| US61/078,983 | 2008-07-08 | ||
| US10436308P | 2008-10-10 | 2008-10-10 | |
| US10436608P | 2008-10-10 | 2008-10-10 | |
| US10436408P | 2008-10-10 | 2008-10-10 | |
| US61/104,366 | 2008-10-10 | ||
| US61/104,364 | 2008-10-10 | ||
| US61/104,363 | 2008-10-10 | ||
| US14865809P | 2009-01-30 | 2009-01-30 | |
| US61/148,658 | 2009-01-30 | ||
| PCT/US2009/049982 WO2010006085A1 (en) | 2008-07-08 | 2009-07-08 | Fatty acid acetylated salicylates and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110042071A KR20110042071A (ko) | 2011-04-22 |
| KR101708065B1 true KR101708065B1 (ko) | 2017-02-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117002838A Expired - Fee Related KR101708065B1 (ko) | 2008-07-08 | 2009-07-08 | 지방산 아세틸화 살리실레이트 및 그 용도 |
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Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5337479B2 (ja) | 2005-05-04 | 2013-11-06 | プロノヴァ・バイオファーマ・ノルゲ・アーエス | 新規化合物 |
| EP2094640A4 (en) | 2006-11-01 | 2015-05-20 | Pronova Biopharma Norge As | ALPHA-SUBSTITUTED OMEGA-3 LIPIDS WHICH ARE ACTIVATORS OR MODULATORS OF THE PEROXISOMPROLIPATOR ACTOR-ACTIVATED RECEPTOR (PPAR) |
| US8741966B2 (en) | 2007-11-09 | 2014-06-03 | Pronova Biopharma Norge As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
| LT2315740T (lt) | 2008-07-08 | 2018-02-26 | Catabasis Pharmaceuticals, Inc. | Acetilinti riebalų rūgščių salicilatai ir jų panaudojimas |
| US9085527B2 (en) | 2008-07-08 | 2015-07-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid acylated salicylates and their uses |
| EP2147910A1 (en) | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
| HRP20190732T1 (hr) | 2009-05-08 | 2019-06-14 | Basf As | Polinezasićene masne kiseline za liječenje bolesti povezanih s kardiovaskularnim, metaboličkim i upalnim područjima bolesti |
| USRE46608E1 (en) | 2009-09-01 | 2017-11-14 | Catabasis Pharmaceuticals, Inc. | Fatty acid niacin conjugates and their uses |
| IN2012DN02661A (enExample) | 2009-09-01 | 2015-09-11 | Catabasis Pharmaceuticals Inc | |
| CN102822141A (zh) * | 2010-01-20 | 2012-12-12 | 普罗诺瓦生物医药挪威公司 | 水杨酸脂肪酸衍生物 |
| US20130190327A1 (en) * | 2010-02-26 | 2013-07-25 | Catabasis Pharmaceuticals Inc | Bis-fatty acid conjugates and their uses |
| US9216224B2 (en) | 2010-03-05 | 2015-12-22 | Catabasis Pharmaceuticals, Inc. | Fatty acid COX inhibitor derivatives and their uses |
| WO2011141341A1 (en) | 2010-05-14 | 2011-11-17 | Iberhospitex, S.A. | Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers |
| JP2014505017A (ja) | 2010-11-05 | 2014-02-27 | プロノヴァ・バイオファーマ・ノルゲ・アーエス | 脂質化合物を用いる処置方法 |
| EP2657227B1 (en) | 2010-12-22 | 2016-04-27 | D. Western Therapeutics Institute, Inc. | Novel substituted isoquinoline derivative |
| US20140315786A1 (en) * | 2011-03-18 | 2014-10-23 | Catabasis Pharmaceuticals, Inc. | Use of intracellular enzymes for the release of covalently linked bioactives |
| WO2012154564A1 (en) * | 2011-05-06 | 2012-11-15 | Catabasis Pharmaceuticals, Inc. | Fatty acid phenolic derivatives and their uses |
| WO2014037832A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
| WO2013045854A1 (fr) * | 2011-09-29 | 2013-04-04 | Ecole Normale Superieure De Lyon | Substrat de peptidase fluorogene |
| BR112014008223A2 (pt) | 2011-10-06 | 2017-04-25 | Bayer Ip Gmbh | heterociclilpiri (mi) dinilpirazol |
| SG11201407300VA (en) | 2012-05-07 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of neurological disorders |
| CA2873093A1 (en) * | 2012-05-07 | 2013-11-14 | Cellixbio Private Limited | Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders |
| WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
| US9266823B2 (en) | 2012-05-08 | 2016-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of parkinson's disease |
| US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
| US9403826B2 (en) | 2012-05-08 | 2016-08-02 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory disorders |
| WO2013168025A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of blood clotting disorders |
| WO2013167991A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic disorders |
| US9242939B2 (en) | 2012-05-10 | 2016-01-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
| WO2013168033A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
| WO2013167999A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurologic diseases |
| US9346742B2 (en) | 2012-05-10 | 2016-05-24 | Cellix Bio Private Limited | Compositions and methods for the treatment of fibromyalgia pain |
| US9315478B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| WO2013168015A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of asthma and allergy |
| US9339484B2 (en) | 2012-05-10 | 2016-05-17 | Cellix Bio Private Limited | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
| WO2013168001A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| WO2013168011A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of chronic pain |
| WO2013168014A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| WO2013168002A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological conditions |
| SG11201407318UA (en) | 2012-05-10 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of metabolic syndrome |
| US9573927B2 (en) | 2012-05-10 | 2017-02-21 | Cellix Bio Private Limited | Compositions and methods for the treatment of severe pain |
| US9227974B2 (en) | 2012-05-23 | 2016-01-05 | Cellex Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
| WO2013175357A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of inflammatory bowel disease |
| US9492409B2 (en) | 2012-05-23 | 2016-11-15 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| AU2013264820A1 (en) | 2012-05-23 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for treatment of mucositis |
| US9434729B2 (en) | 2012-05-23 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
| AU2013264896A1 (en) | 2012-05-23 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| AU2013266087A1 (en) | 2012-05-25 | 2014-12-04 | Catabasis Pharmaceuticals, Inc. | Methods of lowering proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| WO2014004951A1 (en) * | 2012-06-28 | 2014-01-03 | Kean University | Novel fatty acid-salicylate conjugates with enhanced therapeutic properties |
| US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| WO2014020480A2 (en) | 2012-08-03 | 2014-02-06 | Mahesh Kandula | Compositions and methods for the treatment migraine and neurologic diseases |
| US9624168B2 (en) | 2012-09-06 | 2017-04-18 | Cellix Bio Private Limited | Compositions and methods for the treatment inflammation and lipid disorders |
| CA2873029A1 (en) | 2012-09-08 | 2014-03-13 | Cellixbio Private Limited | Compositions and methods for the treatment of inflammation and lipid disorders |
| WO2014115098A1 (en) * | 2013-01-26 | 2014-07-31 | Mahesh Kandula | Compositions and methods for the treatment of neurological diseases and inflammation |
| US11351139B2 (en) | 2013-02-28 | 2022-06-07 | Basf As | Composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same |
| US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| CA2914461A1 (en) | 2013-06-04 | 2014-12-11 | Cellixbio Private Limited | Compositions and methods for the treatment of diabetes and pre-diabetes |
| US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
| EP2889286B1 (en) * | 2013-12-30 | 2016-05-18 | Pax Forschung GmbH | Pharmaceutically active compound for use as anti-inflammatory agent |
| EP3116469B1 (en) | 2014-03-10 | 2018-10-03 | Mary Kay, Inc. | Skin lightening compositions |
| US20170158599A1 (en) * | 2014-07-18 | 2017-06-08 | Joseph D. Ceccoli | Compositions and methods comprising salicylates and polysalicylates |
| EP3240779B1 (en) | 2014-09-26 | 2020-10-28 | Cellixbio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
| CN107207403A (zh) | 2014-09-29 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | 用于治疗多发性硬化的组合物和方法 |
| EP3212626B1 (en) | 2014-10-27 | 2018-11-07 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
| US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
| US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
| US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
| MA41031A (fr) | 2014-11-26 | 2017-10-03 | Catabasis Pharmaceuticals Inc | Conjugués cystéamine-acide gras et leur utilisation comme activateurs de l'autophagie |
| US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| CN110845355A (zh) | 2015-01-06 | 2020-02-28 | 塞尔利克斯生物私人有限公司 | 用于治疗炎症和疼痛的组合物和方法 |
| US20180104201A1 (en) | 2015-04-28 | 2018-04-19 | Pronova Biopharma Norge As | Use of structurally enhanced fatty acids containing sulphur for preventing and or treating non alcoholic steatohepatitis |
| WO2016178066A1 (en) * | 2015-05-01 | 2016-11-10 | Mohan M Alapati | Compositions and methods for the treatment of hyperglycemia and metabolic syndrome |
| NZ750126A (en) * | 2016-08-11 | 2022-07-01 | Cellix Bio Private Ltd | Compositions and methods for the treatment of irritable bowel syndrome |
| WO2018067847A1 (en) * | 2016-10-05 | 2018-04-12 | Baylor College Of Medicine | Structure of gii.4 norovirus protease -design of broad-spectrum protease inhibitors |
| EP3676243A4 (en) * | 2017-09-01 | 2021-05-26 | Curtin University | SYNTHETIC DERIVATIVES OF OLEOYL-LYSOPHOSPHATIDYLINOSITOL (OLEOLYL-LPI) AND ASSOCIATED USES |
| WO2019067975A1 (en) | 2017-09-28 | 2019-04-04 | Sarepta Therapeutics, Inc. | POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY |
| WO2019067981A1 (en) | 2017-09-28 | 2019-04-04 | Sarepta Therapeutics, Inc. | POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY |
| WO2019067979A1 (en) | 2017-09-28 | 2019-04-04 | Sarepta Therapeutics, Inc. | POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY |
| SG11202004115WA (en) * | 2017-11-06 | 2020-06-29 | Catabasis Pharmaceuticals Inc | Edasalonexent dosing regimen for treating muscular dystrophy |
| CN111556748B (zh) * | 2017-11-17 | 2023-04-14 | 浙江越甲药业有限公司 | 一种局部麻醉药物 |
| PT3720431T (pt) | 2017-12-06 | 2024-12-05 | Basf As | Derivados de ácidos gordos para o tratamento da esteato-hepatite não alcoólica |
| WO2020191087A1 (en) | 2019-03-18 | 2020-09-24 | Ptc Therapeutics, Inc. | Therapeutic combinations for use in treating a muscular dystrophy |
| CN114853627B (zh) * | 2022-04-26 | 2023-06-20 | 自然资源部第三海洋研究所 | 一种取代苯甲酸二十二碳六烯酰胺乙基酯衍生物及其制备方法与应用 |
| CN114853628B (zh) * | 2022-05-07 | 2023-10-13 | 自然资源部第三海洋研究所 | 一种二十二碳六烯酰酯衍生物及其制备方法和应用 |
| CN119504664B (zh) * | 2025-01-17 | 2025-06-24 | 广东医科大学附属医院 | 二十碳五烯酸衍生物及其制备方法和应用、防治神经系统疾病药物 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036951A (en) * | 1973-03-12 | 1977-07-19 | Synergistics, Inc. | Ultra-violet filtration with certain aminosalicylic acid esters |
| ES428254A1 (es) | 1974-07-15 | 1976-08-16 | Inst Internacional Terapeutico | Procedimiento para la obtencion de 2-acetoxibenzoatos de n-(2-hidroxietil) amidas de acidos grasos. |
| US4276430A (en) | 1976-12-15 | 1981-06-30 | The Procter & Gamble Company | Analgesic and anti-inflammatory compounds and compositions containing same |
| US4199576A (en) | 1976-12-15 | 1980-04-22 | The Procter & Gamble Company | Analgesic and anti-inflammatory compositions for topical application |
| CA1113486A (en) | 1977-04-01 | 1981-12-01 | Alfred Halpern | Ultra-violet filtration with certain aminosalicylic acid esters |
| US4204517A (en) * | 1978-03-30 | 1980-05-27 | Rumsey Joseph N | Fireplace furnace |
| US4264517A (en) * | 1978-12-11 | 1981-04-28 | G.D. Searle & Co. | Alkylphenyl 5Z,8Z,11Z,14Z,17Z-eicosapentaenoates |
| US4551279A (en) | 1984-01-09 | 1985-11-05 | G. D. Searle & Co. | Protease inhibitors |
| IT1196348B (it) | 1984-11-29 | 1988-11-16 | Italfarmaco Spa | Composti ad attivita'antiinfiammatoria |
| JPS62223159A (ja) | 1986-03-25 | 1987-10-01 | Ono Pharmaceut Co Ltd | (n−置換フエニル)不飽和脂肪酸アミド誘導体、それらの製造方法及びそれらを有効成分として含有する5−リポキシゲナ−ゼ阻害剤 |
| US4670465A (en) * | 1986-05-21 | 1987-06-02 | Syntex (U.S.A.) Inc. | Arachidonic acid analogs |
| US5760261A (en) * | 1990-02-28 | 1998-06-02 | Guttag; Alvin | Higher fatty acid derivatives of salicylic acid and salts thereof |
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| CA2167818A1 (en) | 1993-08-02 | 1995-02-09 | Robert George Whittaker | Therapeutic compound - fatty acid conjugates |
| GB9403857D0 (en) * | 1994-03-01 | 1994-04-20 | Scotia Holdings Plc | Fatty acid derivatives |
| GB9508023D0 (en) * | 1995-04-20 | 1995-06-07 | Scotia Holdings Plc | Fatty acid derivatives |
| MY118354A (en) | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| USRE40546E1 (en) | 1996-05-01 | 2008-10-21 | Scarista, Ltd. | 1,3-Propane diol esters and ethers and methods for their use in drug delivery |
| ATE272055T1 (de) | 1995-05-01 | 2004-08-15 | Scarista Ltd | Nicotinsäureester und diese enthaltende pharmazeutischen zusammensetzungen |
| CN1187813A (zh) * | 1995-05-01 | 1998-07-15 | 斯科舍集团有限公司 | 作为生物活性化合物的脂肪酸酯 |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| GB9622636D0 (en) | 1996-10-30 | 1997-01-08 | Scotia Holdings Plc | Presentation of bioactives |
| US5728732A (en) | 1996-11-27 | 1998-03-17 | Elizabeth Arden Company, Division Of Conopco, Inc. | Skin treatment with salicylic acid esters and retinoids |
| WO2000044800A1 (en) | 1999-01-29 | 2000-08-03 | Amersham Pharmacia Biotech K.K. | Temperature-responsive polymer compound and process for producing the same |
| GB9930026D0 (en) * | 1999-12-21 | 2000-02-09 | Univ Sheffield | Novel compounds of unsaturated fatty acids |
| US6387945B2 (en) | 2000-04-11 | 2002-05-14 | The Regents Of The University Of California | Lipoic acid analogs |
| WO2003080556A1 (en) | 2001-01-19 | 2003-10-02 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. | Amine derivative with potassium channel regulatory function, its preparation and use |
| US6821529B2 (en) | 2001-09-05 | 2004-11-23 | Deanna Jean Nelson | Oligo(ethylene glycoll)-terminated 1,2-dithiolanes and their conjugates useful for preparing self-assembled monolayers |
| JP4321174B2 (ja) | 2002-10-24 | 2009-08-26 | ソニー株式会社 | 可逆性多色記録媒体、及びこれを用いた記録方法 |
| US20040254357A1 (en) * | 2002-12-19 | 2004-12-16 | Zaloga Gary P. | Fatty acid phenolic conjugates |
| WO2006066894A1 (en) | 2004-12-24 | 2006-06-29 | Ctg Pharma S.R.L. | Compounds for treating metabolic syndrome |
| US20070155747A1 (en) | 2005-12-29 | 2007-07-05 | Kadmus Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| WO2007116027A1 (en) | 2006-04-12 | 2007-10-18 | Unilever Plc | Oral composition comprising a polyunsaturated fatty acid and salicylic acid for obtaining an antiinflammatory effect in skin |
| EP2291182A1 (en) | 2008-05-13 | 2011-03-09 | Genmedica Therapeutics SL | Salicylate conjugates useful for treating metabolic disorders |
| LT2315740T (lt) | 2008-07-08 | 2018-02-26 | Catabasis Pharmaceuticals, Inc. | Acetilinti riebalų rūgščių salicilatai ir jų panaudojimas |
| US9085527B2 (en) | 2008-07-08 | 2015-07-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid acylated salicylates and their uses |
| WO2011044138A1 (en) | 2009-10-05 | 2011-04-14 | Catabasis Pharmaceuticals, Inc. | Lipoic acid acylated salicylate derivatives and their uses |
| US20110082120A1 (en) | 2009-10-05 | 2011-04-07 | Milne Jill C | Substituted thioacetic acid salicylate derivatives and their uses |
| CN102822141A (zh) | 2010-01-20 | 2012-12-12 | 普罗诺瓦生物医药挪威公司 | 水杨酸脂肪酸衍生物 |
| WO2012003563A1 (pt) | 2010-07-07 | 2012-01-12 | Universidade Federal De Minas Gerais - Ufmg | Composições farmacêuticas antineoplásicas contendo compostos nitroaromáticos substituídos |
| US20140315786A1 (en) | 2011-03-18 | 2014-10-23 | Catabasis Pharmaceuticals, Inc. | Use of intracellular enzymes for the release of covalently linked bioactives |
| EP2701509A4 (en) | 2011-04-29 | 2015-06-17 | Catabasis Pharmaceuticals Inc | GUANIDINE DERIVATIVES OF FATTY ACID AND GUANIDINE OF SALICYLATE AND USES THEREOF |
| US20130059801A1 (en) | 2011-08-31 | 2013-03-07 | Catabasis Pharmaceuticals, Inc. | Fatty acid amides, compositions and methods of use |
| WO2013175357A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of inflammatory bowel disease |
-
2009
- 2009-07-08 LT LTEP09790168.0T patent/LT2315740T/lt unknown
- 2009-07-08 NZ NZ601932A patent/NZ601932A/en not_active IP Right Cessation
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