KR101705446B1 - 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도 - Google Patents

면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도 Download PDF

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KR101705446B1
KR101705446B1 KR1020150060182A KR20150060182A KR101705446B1 KR 101705446 B1 KR101705446 B1 KR 101705446B1 KR 1020150060182 A KR1020150060182 A KR 1020150060182A KR 20150060182 A KR20150060182 A KR 20150060182A KR 101705446 B1 KR101705446 B1 KR 101705446B1
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cells
present
immune
diseases
compound
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KR20150124923A (ko
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조미라
신동윤
박성환
양철우
최종영
박민정
손혜진
이성희
이선영
김은경
김재경
이승훈
박성혁
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가톨릭대학교 산학협력단
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Priority to AU2015254037A priority Critical patent/AU2015254037B2/en
Priority to JP2016565203A priority patent/JP6462002B2/ja
Priority to CA2946516A priority patent/CA2946516C/en
Priority to PCT/KR2015/004299 priority patent/WO2015167243A1/ko
Publication of KR20150124923A publication Critical patent/KR20150124923A/ko
Priority to US15/339,410 priority patent/US20170114008A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020150060182A 2014-04-29 2015-04-29 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도 Active KR101705446B1 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2015254037A AU2015254037B2 (en) 2014-04-29 2015-04-29 Novel compound having immune disease treatment effect and use thereof
JP2016565203A JP6462002B2 (ja) 2014-04-29 2015-04-29 免疫疾患治療効果を有する新規化合物およびその使用
CA2946516A CA2946516C (en) 2014-04-29 2015-04-29 Compound having immune disease treatment effect and use thereof
PCT/KR2015/004299 WO2015167243A1 (ko) 2014-04-29 2015-04-29 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도
US15/339,410 US20170114008A1 (en) 2014-04-29 2016-10-31 Novel compound having immune disease treatment effect and use thereof
US15/819,758 US10100006B2 (en) 2014-04-29 2017-11-21 Compound having immune disease treatment effect and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140051261 2014-04-29
KR1020140051261 2014-04-29

Publications (2)

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KR20150124923A KR20150124923A (ko) 2015-11-06
KR101705446B1 true KR101705446B1 (ko) 2017-02-09

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KR1020150060182A Active KR101705446B1 (ko) 2014-04-29 2015-04-29 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도

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US (2) US20170114008A1 (https=)
EP (1) EP3130582B8 (https=)
JP (1) JP6462002B2 (https=)
KR (1) KR101705446B1 (https=)
CN (2) CN106458869A (https=)
AU (1) AU2015254037B2 (https=)
CA (1) CA2946516C (https=)
ES (1) ES2702337T3 (https=)

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SI3043785T1 (sl) 2013-09-13 2022-02-28 National University Corporation Chiba University Uporaba R-ketamina in njegove soli kot farmacevtska sredstva
KR101949451B1 (ko) 2015-10-13 2019-05-10 주식회사 이노파마스크린 염증성 장 질환 및 아토피 피부염 치료용 조성물
US20180325931A1 (en) 2017-01-21 2018-11-15 Ningbo Zhiming Biotechnology Co., Ltd. Use of paeoniflorin-6'-o-benzenesulfonate in treatment of sjögren's syndrome
EP3679015B1 (en) * 2017-09-05 2024-07-03 1Globe Biomedical Co., Ltd. Novel therapeutics for central nervous system disorders
JP7548669B2 (ja) * 2018-02-15 2024-09-10 国立大学法人千葉大学 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物
AU2019334202A1 (en) 2018-09-06 2021-03-25 Innopharmascreen, Inc. Methods and compositions for treatment of asthma or parkinson's disease
KR102147802B1 (ko) * 2018-11-07 2020-08-25 가톨릭대학교 산학협력단 신규 화합물 및 칼시뉴린 억제제를 포함하는 이식 거부 반응 또는 이식 거부 질환의 예방 및 치료용 조성물
CA3121664A1 (en) * 2018-12-04 2020-06-11 The Children's Medical Center Corporation Methods and compositions for treating asthma
KR102316961B1 (ko) * 2020-01-29 2021-10-26 프라비바이오 주식회사 면역억제제로서의 벤젠 유도체의 면역억제용 약학적 조성물
CN113907047B (zh) * 2021-12-13 2022-03-11 天津医科大学总医院空港医院 一种自身抗原表位诱导的eam小鼠模型的建立方法
CN115152700B (zh) * 2022-06-28 2023-06-27 广东省人民医院 胶体锰佐剂在制备原发性干燥综合征动物模型中的应用

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US20130095140A1 (en) * 2011-01-07 2013-04-18 Elcelyx Therapeutics, Inc. Biguanide Compositions and Methods of Treating Metabolic Disorders
KR101613371B1 (ko) * 2014-11-10 2016-04-18 가톨릭대학교 산학협력단 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도

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Publication number Priority date Publication date Assignee Title
US20130095140A1 (en) * 2011-01-07 2013-04-18 Elcelyx Therapeutics, Inc. Biguanide Compositions and Methods of Treating Metabolic Disorders
KR101613371B1 (ko) * 2014-11-10 2016-04-18 가톨릭대학교 산학협력단 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도

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Publication number Publication date
EP3130582B8 (en) 2019-01-02
CN106458869A (zh) 2017-02-22
CA2946516A1 (en) 2015-11-05
US20180118668A1 (en) 2018-05-03
KR20150124923A (ko) 2015-11-06
EP3130582A4 (en) 2017-08-30
EP3130582A1 (en) 2017-02-15
ES2702337T3 (es) 2019-02-28
US10100006B2 (en) 2018-10-16
CN111407753A (zh) 2020-07-14
AU2015254037B2 (en) 2019-03-21
AU2015254037A1 (en) 2016-11-17
CA2946516C (en) 2022-02-01
JP2017519723A (ja) 2017-07-20
EP3130582B1 (en) 2018-10-10
US20170114008A1 (en) 2017-04-27
JP6462002B2 (ja) 2019-01-30

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