KR101700722B1 - 응고 인자 ｖｉｉｉ을 정제하는 방법 - Google Patents

응고 인자 ｖｉｉｉ을 정제하는 방법 Download PDF

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KR101700722B1
KR101700722B1 KR1020107028866A KR20107028866A KR101700722B1 KR 101700722 B1 KR101700722 B1 KR 101700722B1 KR 1020107028866 A KR1020107028866 A KR 1020107028866A KR 20107028866 A KR20107028866 A KR 20107028866A KR 101700722 B1 KR101700722 B1 KR 101700722B1
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fviii
resin
chromatography
buffer
column
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KR20110038634A (ko
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카린 보르그발
울리카 에릭손
구스타브 길리암
매츠 예른베르그
스테판 빙게
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옥타파마 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
KR1020107028866A 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법 Active KR101700722B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12940208P 2008-06-24 2008-06-24
US61/129,402 2008-06-24
EP08158893.1 2008-06-24
EP08158893 2008-06-24
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167023450A Division KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법

Publications (2)

Publication Number Publication Date
KR20110038634A KR20110038634A (ko) 2011-04-14
KR101700722B1 true KR101700722B1 (ko) 2017-01-31

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ID=40076764

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020107028866A Active KR101700722B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법
KR1020167023450A Abandoned KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법
KR1020177024076A Active KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법

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KR1020167023450A Abandoned KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법
KR1020177024076A Active KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법

Country Status (19)

Country Link
US (1) US8329871B2 (cg-RX-API-DMAC10.html)
EP (2) EP2300497B1 (cg-RX-API-DMAC10.html)
JP (1) JP5619738B2 (cg-RX-API-DMAC10.html)
KR (3) KR101700722B1 (cg-RX-API-DMAC10.html)
CN (1) CN102066417B (cg-RX-API-DMAC10.html)
AU (1) AU2009264282B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0914695B1 (cg-RX-API-DMAC10.html)
CA (1) CA2728047C (cg-RX-API-DMAC10.html)
DK (2) DK2300497T3 (cg-RX-API-DMAC10.html)
ES (2) ES2538706T3 (cg-RX-API-DMAC10.html)
IL (3) IL209758A (cg-RX-API-DMAC10.html)
MX (1) MX2010013908A (cg-RX-API-DMAC10.html)
PL (1) PL2300497T3 (cg-RX-API-DMAC10.html)
PT (1) PT2300497E (cg-RX-API-DMAC10.html)
RU (2) RU2567811C2 (cg-RX-API-DMAC10.html)
SI (1) SI2300497T1 (cg-RX-API-DMAC10.html)
UA (1) UA100901C2 (cg-RX-API-DMAC10.html)
WO (1) WO2009156430A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201009162B (cg-RX-API-DMAC10.html)

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JP2011525523A (ja) 2011-09-22
RU2698392C2 (ru) 2019-08-26
US20110160435A1 (en) 2011-06-30
ZA201009162B (en) 2011-10-26
UA100901C2 (ru) 2013-02-11
EP2537862A1 (en) 2012-12-26
BRPI0914695B1 (pt) 2022-04-19
PT2300497E (pt) 2012-10-30
DK2300497T3 (da) 2012-10-29
US8329871B2 (en) 2012-12-11
WO2009156430A1 (en) 2009-12-30
RU2015141849A (ru) 2018-12-28
SI2300497T1 (sl) 2013-02-28
KR101804136B1 (ko) 2017-12-04
RU2567811C2 (ru) 2015-11-10
AU2009264282A1 (en) 2009-12-30
KR20170102065A (ko) 2017-09-06
EP2300497A1 (en) 2011-03-30
KR20110038634A (ko) 2011-04-14
RU2015141849A3 (cg-RX-API-DMAC10.html) 2018-12-28
IL229583A0 (en) 2014-01-30
RU2011102437A (ru) 2012-07-27
IL209758A0 (en) 2011-02-28
JP5619738B2 (ja) 2014-11-05
CA2728047C (en) 2019-07-30
CN102066417A (zh) 2011-05-18
CA2728047A1 (en) 2009-12-30
BRPI0914695A2 (pt) 2015-10-20
ES2538706T3 (es) 2015-06-23
PL2300497T3 (pl) 2013-02-28
CN102066417B (zh) 2015-11-25
IL209758A (en) 2014-02-27
KR20160104740A (ko) 2016-09-05
AU2009264282B2 (en) 2013-04-18
EP2537862B1 (en) 2015-03-18
MX2010013908A (es) 2011-01-21
EP2300497B1 (en) 2012-08-08
IL229583B (en) 2018-03-29
DK2537862T3 (en) 2015-06-15
ES2391613T3 (es) 2012-11-28

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