KR101695866B1 - 전립선 암 마커로서의 포스포디에스테라제 9a - Google Patents

전립선 암 마커로서의 포스포디에스테라제 9a Download PDF

Info

Publication number
KR101695866B1
KR101695866B1 KR1020117029709A KR20117029709A KR101695866B1 KR 101695866 B1 KR101695866 B1 KR 101695866B1 KR 1020117029709 A KR1020117029709 A KR 1020117029709A KR 20117029709 A KR20117029709 A KR 20117029709A KR 101695866 B1 KR101695866 B1 KR 101695866B1
Authority
KR
South Korea
Prior art keywords
pde9a
expression
prostate cancer
sample
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020117029709A
Other languages
English (en)
Korean (ko)
Other versions
KR20120034650A (ko
Inventor
랄프 호프만
마일즈 디. 하우스레이
피. 헨더슨 데이비드 제이.
Original Assignee
코닌클리케 필립스 엔.브이.
더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 코닌클리케 필립스 엔.브이., 더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우 filed Critical 코닌클리케 필립스 엔.브이.
Publication of KR20120034650A publication Critical patent/KR20120034650A/ko
Application granted granted Critical
Publication of KR101695866B1 publication Critical patent/KR101695866B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57434Specifically defined cancers of prostate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020117029709A 2009-05-12 2010-05-11 전립선 암 마커로서의 포스포디에스테라제 9a Active KR101695866B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09159957.1 2009-05-12
EP09159957 2009-05-12
PCT/IB2010/052069 WO2010131193A1 (en) 2009-05-12 2010-05-11 Phosphodiesterase 9a as prostate cancer marker

Publications (2)

Publication Number Publication Date
KR20120034650A KR20120034650A (ko) 2012-04-12
KR101695866B1 true KR101695866B1 (ko) 2017-01-13

Family

ID=40847939

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117029709A Active KR101695866B1 (ko) 2009-05-12 2010-05-11 전립선 암 마커로서의 포스포디에스테라제 9a

Country Status (8)

Country Link
US (1) US9828604B2 (enExample)
EP (1) EP2430189B1 (enExample)
JP (1) JP5918694B2 (enExample)
KR (1) KR101695866B1 (enExample)
CN (1) CN102459645B (enExample)
BR (1) BRPI1007620A2 (enExample)
RU (1) RU2592668C2 (enExample)
WO (1) WO2010131193A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101675664B1 (ko) 2015-01-30 2016-11-11 경희대학교 산학협력단 전립선암 예방 또는 치료용 조성물
EP3303616B1 (en) 2015-05-29 2021-01-06 Koninklijke Philips N.V. Methods of prostate cancer prognosis
KR20180085387A (ko) 2016-12-27 2018-07-27 경희대학교 산학협력단 Trail 저항성 암 예방 또는 치료용 조성물
CN107119124B (zh) * 2017-05-10 2021-05-11 清华大学 一种检测待测样本中目标miRNA的含量的方法
KR102080887B1 (ko) * 2017-11-07 2020-02-24 고려대학교 산학협력단 Gcc2 유전자 또는 단백질을 과발현하는 엑소좀 기반 폐암 진단 또는 예후 예측용 마커 조성물
CN114349857B (zh) * 2022-03-15 2022-05-24 诺赛联合(北京)生物医学科技有限公司 一种Treg细胞制备方法以及在自身免疫性疾病方面的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029873A1 (en) * 1997-12-09 1999-06-17 Incyte Pharmaceuticals, Inc. Cyclic gmp phosphodiesterase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090176722A9 (en) 2000-01-28 2009-07-09 Shiv Srivastava Androgen-regulated PMEPA1 gene and polypeptides
AU2003301894A1 (en) 2002-11-08 2004-06-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)
WO2004053494A1 (en) * 2002-12-09 2004-06-24 Bayer Healthcare Ag DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 9a2 (PDE9a2)
AU2003288171A1 (en) * 2002-12-09 2004-06-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 9a3 (pde9a3)
AU2003289894A1 (en) * 2002-12-09 2004-06-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 9a4 (pde9a4)
AU2003283427A1 (en) 2002-12-09 2004-06-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with phosphodiesterase 9a1 (pde9a1)
US7405237B2 (en) 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
EP2074225B1 (en) 2006-10-10 2014-12-03 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029873A1 (en) * 1997-12-09 1999-06-17 Incyte Pharmaceuticals, Inc. Cyclic gmp phosphodiesterase

Also Published As

Publication number Publication date
CN102459645B (zh) 2023-05-30
EP2430189A1 (en) 2012-03-21
US20120065100A1 (en) 2012-03-15
JP2012526543A (ja) 2012-11-01
CN102459645A (zh) 2012-05-16
BRPI1007620A2 (pt) 2016-02-23
WO2010131193A1 (en) 2010-11-18
US9828604B2 (en) 2017-11-28
JP5918694B2 (ja) 2016-05-18
KR20120034650A (ko) 2012-04-12
EP2430189B1 (en) 2018-11-21
WO2010131193A8 (en) 2011-12-08
RU2592668C2 (ru) 2016-07-27
RU2011150291A (ru) 2013-06-20

Similar Documents

Publication Publication Date Title
KR102657306B1 (ko) 전립선암의 진단 및 치료에서 필라민을 포함하는 마커의 용도
CN101687050A (zh) 用于鉴别原发起源不明的癌的起源的方法和材料
TW201632629A (zh) 用於癌症診斷與預後的方法
KR20150023904A (ko) 전립선암의 진단 및 치료에서의 마커의 용도
US20090305284A1 (en) Methods for Identifying Risk of Breast Cancer and Treatments Thereof
KR102613599B1 (ko) 뇌경색 발증 리스크 예측 방법
KR20130123357A (ko) 저산소증과 관련된 질환의 진단방법 및 키트
KR20180049093A (ko) 신규한 바이오마커 및 암의 치료 방법
KR101695866B1 (ko) 전립선 암 마커로서의 포스포디에스테라제 9a
EP3102697A1 (en) Method for predicting the response to an anti-her2 containing therapy and/or chemotherapy in patients with breast cancer
KR101818352B1 (ko) 방광암의 진단 및 예후 예측용 바이오 마커 및 그의 용도
TWI849576B (zh) 基因標記的用途
AU2023203393A1 (en) Compositions and methods for screening and identifying clinically aggressive prostate cancer
CN114450591A (zh) 基于确定fgfr的分类样本的方法
DK2951317T3 (en) PROCEDURE FOR PREDICTING THE BENEFIT OF INCLUSING TAXAN IN A CHEMOTHERAPY PLAN FOR BREAST CANCER PATIENTS
WO2006022638A1 (en) Methods for identifying risk of type ii diabetes and treatments thereof
KR20130087585A (ko) 저도 염증을 검출하는 방법
KR20050008644A (ko) 위암에서의 유전자 발현 프로파일
US20090258344A1 (en) Methods for identifying risk of breast cancer and treatments thereof
KR102326582B1 (ko) 청각장애의 진단용 마커 및 그의 용도
KR102274721B1 (ko) 난소암 진단을 위한 돌연변이 유전자 및 이를 이용한 진단 방법
CN116355923A (zh) 先天性心脏病相关dgkd基因新发变异位点及其应用
KR20130048240A (ko) Pcbp―1 항원에 대한 모노클로날 항체, 및 그의 용도
Class et al. Patent application title: MARKERS OF MELANOMA AND USES THEREOF Inventors: Luca Sigalotti (Maniago (pn), IT) Michele Maio (Roveredo In Piano (pn), IT) Assignees: CENTRO DI RIFERIMENTO ONCOLOGICO-INSTITUTO NAZIONALE TUMORI-AVIANO AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
JP2003102483A (ja) アクチン脱重合因子・コフィリンを脱リン酸化する酵素を含む、ヒト由来の新規タンパク質およびその遺伝子

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20111212

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20150511

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20160523

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20161128

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20170106

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20170109

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20200103

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20200103

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20221228

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20231228

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20241224

Start annual number: 9

End annual number: 9