CN114450591A - 基于确定fgfr的分类样本的方法 - Google Patents
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Abstract
本发明涉及一种对患有患尿路上皮癌或膀胱癌或具有发展尿路上皮癌或膀胱癌的风险的患者的样本进行分类的方法，所述方法包括以下步骤：a)确定来自所述患者的所述样本中存在或不存在FGFR基因中的改变和/或至少一个编码选自FGFR1、FGFR2、FGFR3或FGFR4受体的基因的表达水平，和b)将步骤a)的结果得到的所述患者的样本分为至少两种分类中的一种，所述分类包括对于用抗癌剂的治疗的良好预后和不良预后。
Description
技术领域
本申请涉及分子诊断的领域。
背景技术
尿路上皮癌(UC)是全球10种最常见的恶性肿瘤之一，其具有近386000例新发病例和近150200例死亡/年，其特征是高复发率和进展率。几十年来，转移性UC的唯一治疗方案是基于铂的化疗，其伴随着≤15％的低5年总生存率且标准化疗方案失败的患者预后极差。
免疫疗法代表了一种新兴的抗癌治疗概念。特别是，靶向CTLA4、PD-1或PD-L1的抗体取得惊人的治疗成功，例如在被认为是高度免疫原性肿瘤的转移性黑色素瘤患者中。此外，抗体如纳武利尤单抗(Nivolumab)，已被成功用于治疗全身性晚期非小细胞肺癌和肾细胞癌。这些疗法的成功在突变负荷高的肿瘤类型中尤其令人信服，如非小细胞肺癌或黑色素瘤。
UC是一种体细胞突变率最高的癌症，并因此由于新抗原数量的增加，其被认为是高度免疫原性肿瘤。在过去两年，发表了几项对疗法应答具有良好结果的研究。而一些研究表明，获益与免疫组织化学染色确定的PD-L1表达无关。后来的研究证明了PD-L1表达状态依赖性的应答(阿替丽珠单抗(Atezolizumab)、帕博利珠单抗(Pembrolizumab))。
目前，肿瘤浸润免疫细胞(IC)的PD-L1染色似乎仅检测到潜在疗法应答者的一个子集，但到目前为止不是它们的全部。基因表达研究表明，阿替丽珠单抗对可以富集FGFR3突变的luminal I型肿瘤患者的获益较低。异常FGFR信号传导可以通过直接驱动癌细胞增殖和存活以及支持血管生成来促进肿瘤发展。
在晚期肌层浸润性膀胱癌(≥T2期)中，5％至20％的患者在FGFR3癌基因中存在点突变，而40％的患者存在FGFR3蛋白表达的上调。FGFR3在上尿路UC中也经常发生改变，而在高级别上尿路UC中的改变比在膀胱UC中的更常见(35.6％相较于21.6％，P＝0.065)。FGFR突变状态、免疫浸润、免疫疗法靶点(如PDL1)的表达与免疫疗法方法的应答之间的相互作用在很大程度上是未知的，但在FGFR抑制剂(如厄达替尼(Erdafitinib))方面有潜在的协同或互补治疗选择。
1.2研究范围
本研究旨在评价具有晚期尿路上皮癌的患者中FGFR3突变以及FGFR2和FGFR3基因融合物对抗PD-1和抗PD-L1治疗结局的预测值。在FGFR表达、分子亚型和PD1/PDL1状态的背景下，进一步评价了预后相关性。
因此，本发明的一个目的是鉴定化疗和/或免疫肿瘤疗法后预后不良的UC患者。
本发明的另一个目的是鉴定可以从FGFR抑制剂中获益的那些UC患者。
用根据本发明的独立权利要求的方法和手段，满足了这些和其他目的。从属权利要求与具体实施方案有关。
发明内容
本发明提供了一种对患有尿路上皮癌或膀胱癌或具有发展尿路上皮癌或膀胱癌的风险的患者的样本进行分类的方法。所述方法包括以下步骤：a)确定来自所述患者的所述样本中存在或不存在FGFR基因中的改变和/或至少一个编码选自FGFR1、FGFR2、FGFR3或FGFR4受体的基因的表达水平，和b)将步骤a)的结果得到的所述患者的样本分为至少两种分类中的一种。
附图简述
图1：比较男性和女性患者(A)以及用PD1抑制剂(纳武利尤单抗/帕博利珠单抗)治疗的患者与用PDL1抑制剂(阿替丽珠单抗，B)治疗的患者的总生存期的Kaplan Meier分析。在用抗PD1和抗PDL1免疫肿瘤疗法的这些患者组中，没有观察到显著的生存期差异。
图2：IO治疗后疾病特异性生存期(DSS)的Kaplan Meier分析，其比较原发性肿瘤组织队列中FGFR2 mRNA高表达和低表达的患者。
图3：IO治疗后疾病特异性生存期(DSS)的Kaplan Meier分析，其比较了总队列(包括转移)中FGFR2 mRNA高表达和低表达的患者。
图4：IO治疗后原发性肿瘤组织队列中疾病特异性生存期(DSS)的Kaplan Meier分析，其比较了按FGFR改变状态分层的(1)FGFR2 mRNA高表达患者与(2)FGFR2 mRNA低表达患者(2a：FGFR2 mRNA低表达且没有FGFR改变，2b：FGFR2 mRNA低表达且有FGFR改变)。
图5：IO治疗后总队列(包括转移)中疾病特异性生存期(DSS)的Kaplan Meier分析，其比较了按FGFR改变状态分层的(1)FGFR2 mRNA高表达患者与(2)FGFR2 mRNA低表达患者(2a：FGFR2 mRNA低表达且没有FGFR改变，2b：FGFR2 mRNA低表达且有FGFR改变)。
图6：IO治疗后原发性肿瘤组织队列中疾病特异性生存期(DSS)的Kaplan Meier分析，其比较了按FGFR3 mRNA水平分层的FGFR2 mRNA高表达患者与FGFR2 mRNA低表达患者。
图7：IO治疗后总队列(包括转移)中疾病特异性生存期(DSS)的Kaplan Meier分析，其比较按FGFR3 mRNA水平分层的FGFR2 mRNA高表达患者(29例患者)与FGFR2mRNA低表达患者。FGFR2 mRNA低表达和FGFR3 mRNA低表达(10例患者)。FGFR2mRNA低表达和FGFR3mRNA高表达(26例患者)。
图8：FGFR3-TACC3重排的结构。FGFR3和TACC3基因座的基因组组成(上图)。在报告的FGFR3-TACC3变体中，基因组重排导致FGFR3基因外显子17和一小部分内含子17与TACC3基因内含子10并列(juxtaposition)，导致FGFR3外显子17和TACC3外显子11的框内融合，如联合mRNA(joint mRNA)的Sanger序列所示。这一融合结构是鉴定出的最常见的mRNA融合变体之一。方框表示FGFR3-TACC3的RT-PCR筛选试验中使用的诊断性引物的位置。FGFR3-TACC3的结构总是包括FGFR3的TK结构域和TACC3的卷曲螺旋结构域。FGFR3的激酶结构域位于外显子12-18。图8还显示了将在下文讨论的引物组合。用于检测的探针未在图8示出。
A行显示引物组合，其可以用于检测和定量FGFR3-TACC3融合构建体的存在。
B行显示引物组合，其通过检测FGFR3的N端的存在和FGFR3的C端的存在或不存在(虚线)可以用于检测和定量野生型FGFR3与FGFR3-TACC3融合构建体。FGFR3的C端仅存在于FGFR3野生型中，而在融合构建体中缺失。
C行显示引物组合，其通过检测TACC3的C端的存在和TACC3的N端的存在或不存在(虚线)可以用于检测和定量野生型TACC3与FGFR3-TACC3融合构建体。TACC3的N端仅存在于TACC3野生型中，而在融合构建体中缺失。
D行显示引物组合，其通过检测FGFR3外显子16的存在(存在于FGFR3野生型和融合构建体中)以及FGFR3外显子18的存在或不存在(虚线)(存在于FGFR3野生型中而在融合构建体中缺失)可以用于检测和定量野生型FGFR3-TACC3融合构建体。
下表再次显示引物组合
图9：用根据图8中C行引物进行的表达实验的结果。通过检测靶向FGFR2和FGFR3(其在已知融合基因中得到保留或缺失，因此可以过表达)的3'-序列的RT-qPCR分析，所使用的引物组合能够检测和定量野生型FGFR3-TACC3融合构建体，其已经被建立。在
实时PCR系统(Applied
USA)中使用
快速高级mastermix(Applied
USA)进行FGFR2和FGFR3的定量PCR(qPCR)。用对各研究的基因特异性的反向引物使用Superscript
逆转录酶试剂盒(Invitrogen,USA)对FFPE组织样本中的RNA进行cDNA的合成。具有经验证的FGFR融合的细胞系和样本(粗体描述；例如RT4，RT112和Pt1至Pt4)显示断点的靶序列5’的mRNA表达升高，而融合断点的靶序列3’的mRNA表达降低，导致断点前后个体FGFR mRNA表达的相对失衡。使用对FGFR3-TACC3融合物的特异性PCR，分析了显示差异(超过1个CT)和/或高FGFR3和FGFR2表达的样本，并通过下一代测序和使用扩增引物的双向Sanger测序进一步进行验证。
a)FGFR3外显子16的存在(存在于FGFR3野生型以及融合产物中)
b)FGFR3外显子18的存在或不存在(其存在于FGFR3野生型中，但在融合产物中缺失)。
两个外显子表达相似的样本未显示FGFR3-TACCC3基因重排或融合，而外显子16和外显子18表达失衡(例如，外显子16的表达高于18)的样本确实显示FGFR3-TACCC3的此类基因重排或融合。
图10：使用根据图8中C行引物进行的表达实验结果的进一步分析。
A)总队列中FGFR3外显子16和外显子18水平的相对mRNA表达水平。红色方块表示的患者来自具有FGFR3的基因融合物的尿路上皮癌患者，而无FGF受体基因融合物的患者表示为实心黑色三角形圆圈。具有FGFR基因融合物的患者表现出相对较高的外显子16而中等外显子18的mRNA表达。
B)通过从外显子16表达中减去外显子18的相对mRNA表达，构建基因比(即((40-DCT FGFR3外显子16)-(40-DCT FGFR3外显子18))，这显示了显著较高的基因比(>DDCT 2)，尤其是在含FGFR3基因融合物的肿瘤中。相比之下，无FGFR3基因融合物的患者表现出较低的基因比(～DDCT 0)，这表明FGFR3外显子16和FGFR3外显子18的表达平衡。
图11：描述研究中患者队列和样本选择的流程图。
图12显示具有本申请所指外显子的TACC3的基因结构。
图13显示具有本申请所指外显子的FGFR3的基因结构。
图14显示FGFR3-TACC3融合蛋白的不同变体：(A)FGFR3-TACC3融合特异性RT-PCR扩增子的琼脂糖凝胶分离。(B)FGFR3-TACC3融合特异性RT-PCR产物的Sanger测序色谱图。箭头表示2个基因的断开点。摘自Kurobe et al(2016)，其内容通过引用并入本文。
发明详述
在对本发明进行详细描述之前，应理解的是，本发明不限于所描述的器械的特定组件部分或所描述的方法的工艺步骤，因为此类器械和方法可以发生变化。还应理解的是，本文使用的术语仅用于描述特定实施方案，并不旨在限制。必须指出的是，正如本说明书和所附权利要求中所使用的，单数形式“一(a)”、“一(an)”和“一(the)”包括单数和/或复数指代，除非上下文另有明确指明。此外，可以理解的是，如果给出了由数值分隔的参数范围，则认为该范围包括这些限值。
应进一步理解的是，本文公开的实施方案不应理解为彼此不相关的单个实施方案。与一个实施方案讨论的特征也意味着与本文所示的其他实施方案一起得到公开。在一种情况下，如果特定的特征不与一个实施方案一起公开，但与另一实施方案一起公开，则本领域技术人员将理解这不一定意味着所述特征并不意味着与所述其他实施方案一起公开。本领域技术人员将理解，本申请的主旨也是为其他实施方案公开所述特征，但是仅仅为了清楚的目的并且将本说明书保持在可管理范围内而没有这样做。
此外，本文所提及的现有技术文件的内容已通过引用并入本文。这尤其适用于公开标准或常规方法的现有技术文件。在这种情况下，通过引用并入的主要目的是提供充分的授权公开，并避免冗长的重复。
根据本发明的第一方面，提供了一种对患有尿路上皮癌或膀胱癌或具有发展尿路上皮癌或膀胱癌的风险的患者的样本进行分类的方法，所述方法包括以下步骤：
a)在所述患者的所述样本中确定：
·FGFR基因中是否存在改变，和/或
·编码选自FGFR1、FGFR2、FGFR3或FGFR4的受体的至少一个基因的表达水平，和
b)将步骤a)的结果得到的所述患者的所述样本分类为至少两种分类中的一种。
正如其名称所示，成纤维细胞生长因子受体(FGFR)是与成纤维细胞生长因子蛋白家族成员结合的受体。成纤维细胞生长因子受体由胞外配体结构域组成，胞外配体结构域由三个免疫球蛋白样结构域、一个单跨膜螺旋结构域和一个具有酪氨酸激酶活性的胞内结构域组成。这些受体结合成纤维细胞生长因子，这是最大的生长因子配体家族的成员，包括22个成员。
FGFR是具有多个结构域的～800个氨基酸的受体酪氨酸激酶，其包括3个胞外免疫球蛋白样结构域(D1-D3)、跨膜结构域(TM)和2个胞内酪氨酸激酶结构域(TK1和TK2)。
4个成纤维细胞生长因子受体(FGFR)基因的天然交替剪接导致产生超过48种不同的FGFR亚型。这些亚型在其配体结合特性和激酶结构域中各不相同。
三个免疫球蛋白(Ig)样结构域在D1和D2之间呈现一段酸性氨基酸(“酸盒”)。这一“酸盒”可以参与调节FGF与FGFR的结合。免疫球蛋白样结构域D2和D3足以与FGF结合。每个受体可以被几种FGF激活。在许多情况下，FGF本身也可以激活超过一种的受体(即FGF1，结合所有7种主要FGFR)。然而，FGF7只能激活FGFR2，最近发现FGF18激活FGFR3。
迄今为止，已在脊椎动物中鉴定出表1所示的以下FGFR以及相应的mRNA序列，以及所有这些FGFR均属于酪氨酸激酶超家族(FGFR1至FGFR4)。应该注意的是，本领域技术人员能够选择合适的引物组合(以及任选地探针)，以根据本文提供的公开结合其常规知识来鉴定和定量这些基因中任何一个的表达。
表1:FGFR1–FGFR4的详细信息
通常，术语“尿路上皮癌”和“膀胱癌”的范围重叠，并有时可以互换使用。有时，术语“尿路上皮癌”可用作通用定义，而“膀胱癌”用于确定给定种类的尿路上皮癌。有时，术语“尿路上皮癌”用于指定输尿管中的癌症，而“膀胱癌”用于指定膀胱中的癌症。
在一个实施方案中，确定其表达水平的两个基因是FGFR2和FGFR3。
如本文使用的，术语“FGFR基因中的改变”尤其涉及其中FGFR3基因发生改变的样本，例如，通过突变或融合。在一个实施方案中，确定其改变的基因是FGFR3。
FGFR3基因的典型改变是与TACC3的融合。
根据本发明的一个或多个实施方案，将步骤a)结果得到的所述患者的样本分类为至少两种分类中的一种的步骤b)包括分类为以下一种：
(i)对于用抗癌剂的治疗的预后良好，或
(ii)对于用抗癌剂的治疗的预后不良。
根据本发明的一个或多个实施方案，基于步骤b)中的分类，选择治疗模式，该治疗模式选自以下一种：
(i)在对于用抗癌剂的治疗预后良好的情况下施用抗癌剂，或
(ii)在对于用抗癌剂的治疗预后不良好的情况下施用FGFR抑制剂。
根据本发明的一个或多个实施方案，所述表达水平由以下至少一项进行确定：
(i)基于杂交的方法，其中使用标记的单链探针，
(ii)基于PCR的方法，所述方法包括聚合酶链式反应(PCR)，
(iii)基于特定分子的电化学检测的方法，所述方法涵盖分子在产生可检测信号的情况下结合的电极系统，
(iv)基于阵列的方法，其包括使用微阵列和/或生物芯片，和/或
(v)免疫学方法，其中使用一种或多种靶特异性蛋白结合剂。
如本文中使用的术语“基于PCR的方法”是指包括聚合酶链式反应(PCR)的方法。这是一种通过酶复制来指数扩增核酸(如DNA或RNA)无需使用活生物体的方法。由于PCR是体外技术，它可以在不限制DNA形式的情况下进行，并且可以被广泛的修饰来进行大量的基因操作。在确定表达水平时，例如，通过(1)借助逆转录酶将完整的mRNA库(所谓的转录组)逆转录为cDNA，和(2)借助各自的引物检测给定的cDNA的存在，基于PCR的方法可以用于检测给定mRNA的存在。这一方法通常被称为逆转录酶PCR(rtPCR)。此外，例如，基于PCR的方法包括实时PCR，和特别适用于表达水平分析、动力学或定量PCR(qPCR)。
术语“定量实时PCR”(qPCR)是指允许对样本中的模板进行定量的任何类型的PCR方法。定量实时PCR包括不同的性能或产品检测技术，例如TaqMan技术或LightCycler技术。例如，TaqMan技术使用双标记荧光探针。TaqMan实时PCR在PCR的指数阶段而不是像常规PCR那样在终点通过荧光团测量产物的积累。产物的指数增加用于确定阈值循环CT，即检测到荧光呈显著指数增加的PCR循环数，且其与反应中存在的DNA模板拷贝数直接相关。该反应的设置与传统PCR非常相似，但在实时热循环仪中进行，其允许测量PCR管中的荧光分子。与常规PCR不同，在TaqMan实时PCR中，在反应中加入探针，即与DNA模板内20-60个核苷酸片段互补并位于两个引物之间的单链寡核苷酸。荧光报告物或荧光团(例如，6-羧基荧光素，缩写词：FAM或四氯荧光素，缩写词：TET)和猝灭剂(例如，四甲基罗丹明，缩写词：TAMRA，二氢环吡咯并吲哚三肽“小沟结合剂”，缩写词：MGB)分别共价连接到探针的5′端和3′端[2]。连接在探针上的荧光团与猝灭剂之间的紧密接近抑制来自荧光团的荧光。在PCR期间，随着DNA合成的开始，Taq聚合酶的5′至3′核酸外切酶活性降低与模板退火的探针比例(因此其名称：Taq聚合酶+PacMan)。探针的降解将荧光团从其中释放出来，并打破与猝灭剂的紧密接近，从而解除猝灭效应并使荧光团产生荧光。因此，在实时PCR热循环仪中检测到的荧光与释放的荧光团和PCR中存在的DNA模板量成正比。
本文的“微阵列”也是指“生物芯片”或“生物学芯片”。离散区域密度为至少约100/cm2，优选至少约1000/cm2的区域阵列。微阵列中的区域具有典型的尺寸，例如直径，其范围为约10-250μm，并与阵列中的其他区域分开约相同的距离。
如本文使用的术语“基于杂交的方法”是指将互补的单链核酸或核苷酸类似物结合到单个双链分子中的过程的方法。核苷酸或核苷酸类似物在正常情况下会与其补体结合，因此两条完全互补的链会容易地相互结合。在生物分析中，经常标记的单链探针是为了找到互补的靶序列。如果样品中存在此类序列，探针将与所述序列杂交，然后由于标记可以被检测到。其他基于杂交的方法包括微阵列和/或生物芯片方法。因此，将探针固定在固相上，然后将其暴露于样本。如果样本中存在互补核酸，这些核酸将与探针杂交，并从而可以被检测到。这些方法也被称为“基于阵列的方法”。然而，另一种基于杂交的方法是PCR，如上所述。当确定表达水平时，基于杂交的方法可以例如用于确定给定基因的mRNA量。
术语“基于分子的电化学检测的方法”涉及使用电极系统的方法，分子特别是生物分子，如蛋白、核酸、抗原、抗体等，在产生可检测信号的情况下与之结合。例如，在本发明申请人提交的WO0242759、WO0241992和WO02097413中公开此类方法，其内容通过引用并入本文。这些探测器包括具有平坦表面的基底(例如，由硅芯片的晶体学表面形成)和电探测器(可以采用，例如，指状组合型电极或二维电极阵列的形状)。这些电极携带探针分子，例如核酸探针，能够特异性结合靶分子，例如靶核酸分子。例如，通过巯基-金结合固定探针分子。出于这个目的，在其5′-或3′端用巯基修饰探针，巯基与包含金表面的电极结合。例如，这些靶核酸分子可以携带酶标记，如辣根过氧化物酶(HRP)或碱性磷酸酶。靶分子与探针结合后，加入底物(例如，α-磷酸萘酯或3,3'5,5'-四甲基联苯胺，其通过所述酶转化，尤其是在氧化还原反应中)。所述反应的产物，或由于电子交换在所述反应中产生的电流，可以在电子检测器的帮助下以位点特异性方式被检测到。
术语“免疫学方法”是指使用一种或多种靶特异性蛋白结合剂的方法。此类方法包括Western Blot(WB)、免疫组织化学(IHC)、免疫荧光(IF)、免疫细胞化学(ICC)和ELISA等，均为常规方法。尤其是，适用于上述方法的此类蛋白结合剂是指与FGFR1、FGFR2、FGFR3或FGFR4中的任何一种或与其改变的变体结合的多克隆抗体或单克隆抗体。此类抗体可以由本领域技术人员用常规方法(免疫/杂交瘤)来产生，以及也可以购自常规供应商。下表仅显示示例的非限制性列表：
| 类型 | 目录号/克隆ID | 供应商 |
| 抗FGFR1抗体 | EPR806Y | AbCam |
| 抗FGFR2抗体 | PA5-14651 | ThermoFisher |
| 抗FGFR3抗体 | OTI1B10 | Origene |
| 抗FGFR4抗体 | sc-136988 | SantaCRuz Biotechnology |
根据本发明的一个或多个实施方案，所述FGFR基因的改变通过以下来确定：
(i)确定改变的FGFR变体的表达水平，
(ii)确定至少以下的表达水平
·并入改变的FGFR变体的FGFR外显子，和
·未并入改变的FGFR变体的FGFR外显子，
和将两者进行比较，
(iii)对各自的FGFR基因进行测序，以鉴定相应的改变，和/或
(iv)SNaPshot突变分析。
本领域技术人员熟知不同的方法，并在本文其他地方讨论。
此类改变的FGFR变体优选是FGFR3-TACC3融合，尤其是如Costa等人(2016)(其内容通过引用并入本文)或Lasorella等人(2017)(其内容通过引用并入本文)或Kurobe等人(2016)(其内容通过引用并入本文)所公开的。
根据本发明的一个或多个实施方案，所述表达水平通过以下至少一个的实时聚合酶链式反应(RT-PCR或qPCR)来确定：
·FGFR野生型mRNA和/或
·改变的FGFR变体的mRNA。
出于这一目的，合适的引物和任选地探针是必要的，并在本文其他地方进行公开。在此类方法中，将mRNA转录本逆转录为cDNA，并然后在qPCR反应中使用cDNA作为模板，以检测和定量基因表达产物。
在RT-PCR或qPCR中，在PCR期间监测靶向的DNA分子的扩增，即实时地，而不是像常规PCR一样在其终点。实时PCR可以定量使用(定量实时PCR)，以及半定量使用，即高于/低于一定量的DNA分子(半定量实时PCR)。
实时PCR中检测PCR产物的两种常用方法是：(1)嵌入任何双链DNA的非特异性荧光染料，和(2)由标记荧光报告物的寡核苷酸组成的序列特异性DNA探针，其允许仅在探针与其互补序列杂交后进行检测。
给定基因表达水平的一个量度是Ct(“循环阈值”)。Ct定义为荧光信号超过阈值(即超过背景水平)所需的循环数。Ct水平与样本中靶mRNA的量成反比，即Ct水平越低，样本中靶mRNA的量越大，即各自基因的表达水平越高。
根据本发明的一个或多个实施方案，方法的特征在于：步骤a)中确定的一个或多个表达水平在步骤b)之前用一个或多个参考基因的一个或多个表达水平进行归一化，以获得一个或多个归一化的表达水平。
Kozera和Rapacz(2013)讨论了PCR中的参考基因，其内容通过引用并入本文。
为了归一化给定基因的表达水平，优选与参考基因进行比较。在一个实施方案中，通过以下公式计算FGFR(在下文中称为靶基因)，优选FGFR2和FGFR3的归一化的基因表达：
40–((Ct靶基因)–(Ct管家))
本文也称为“ΔCT”。
根据本发明的一个或多个实施方案，方法的特征在于所述一个或多个参考基因是至少一个管家基因。
本文使用的术语“管家基因”是指参考基因的更专门的形式。它是指一组编码蛋白的基因，其活性对维持细胞功能至关重要。这些基因通常在所有细胞类型中都类似地进行表达。管家基因包括但不限于甘油醛-3-磷酸脱氢酶(GAPDH)、Cypl、白蛋白、肌动蛋白(例如β-肌动蛋白)、微管蛋白、亲环蛋白、次黄嘌呤磷酸核糖转移酶(hypoxantinephsophoribosyltransferase，HRPT)、L32、28S和18S。
根据本发明的一个或多个实施方案，选自CALM2、B2M和/或RPL37A的至少一个管家基因，如下表2所示。应该注意的是，本领域技术人员能够选择合适的引物组合(以及任选地探针)，以根据本文提供的公开结合其常规知识来鉴定和定量这些基因中任何一个的表达。
表2：管家基因的详细信息
根据本发明的一个或多个实施方案，确定选自KRT5、ERBB2、KRT20、PD1、PD-L1和/或TACC3的至少一个以上基因的表达水平并任选地归一化。这些基因见下表3。
应该注意的是，本领域技术人员能够选择合适的引物组合(以及任选地探针)，以根据本文提供的公开结合其常规知识来鉴定和定量这些基因中任何一个的表达。
表3：可确定的其他基因的详细信息
注意的是，表中给出的NCBI参考编号仅为示例。各自mRNA的其他亚型或变体可以是存在的，并容易被本领域技术人员在各自数据库中找到。
应该注意的是，本领域技术人员能够选择合适的引物组合(以及任选地探针)，以根据本文提供的公开结合其常规知识来鉴定和定量这些基因中任何一个的表达。
根据本发明的一个或多个实施方案，方法的特征在于尿路上皮癌或膀胱癌是T2、T3或T4期癌症。
尿路上皮癌或膀胱癌分为以下四个阶段：
T1：肿瘤已扩散到结缔组织(称为固有层)，将膀胱内壁与下方肌肉分开，但不累及膀胱壁肌肉。
T2：肿瘤已扩散至膀胱壁肌肉。
T3：肿瘤已生长到膀胱周组织(包围膀胱的脂肪组织)。
T4：肿瘤已扩散到以下任何部位：腹壁、盆壁、男性的前列腺或精囊(携带精液的管道)或女性的子宫或阴道。
根据本发明的一个或多个实施方案，步骤b)中的分类依赖于FGFR2和/或FGFR3的表达水平。
优选地，步骤b)中的分类分别依赖于FGFR2和FGFR3表达水平之间的比值或其归一化的表达水平。因此，此类方法致力于确定存在基因间失衡。
14.根据前述任何一项权利要求所述的方法，其中步骤b)中的分类依赖于是否存在FGFR基因中的改变，优选FGFR3基因中的改变。
例如，FGFR基因(优选FGFR3基因)中的此类改变是FGFR3与TACC3之间的融合，将在本文中进行讨论。此类改变导致基因内失衡。此类突变可以导致FGFR3激酶结构域的过度活性，并因此可以具有与FGFR3相对过表达相似的作用。
如本文使用的，术语“上调”涉及给定样本中基因表达(即转录的mRNA或翻译的蛋白的量)较高的情况。在一个实施方案中，其比健康患者或正常患者的比较样本中的表达高至少1.3倍。
如本文使用的，术语“过表达”涉及给定样本中基因表达(即转录的mRNA或翻译的蛋白的量)较高的情况。在一个实施方案中，其比健康患者或正常患者的比较样本中的表达高至少1.3倍。
在一个实施方案中，如果其ΔCT值≥35，则认为FGFR2是上调或过表达的。
在一个实施方案中，如果其ΔCT值≥33.97，则认为FGFR3是上调或过表达的。
如本文使用的，术语“下调”涉及给定样本中基因表达(即转录的mRNA或翻译的蛋白的量)较低的情况。在一个实施方案中，其比健康患者或正常患者的比较样本中的表达低至少1.3倍。
如本文使用的，术语“低表达”涉及给定样本中基因表达(即转录的mRNA或翻译的蛋白的量)较低的情况。在一个实施方案中，其比健康患者或正常患者的比较样本中的表达低至少1.3倍。
在一个实施方案中，如果其ΔCT值<35，则认为FGFR2是下调或低表达的。在一个实施方案中，如果其ΔCT值<33.97，则认为FGFR3是下调或低表达的。
如本文使用的，术语“FGFR基因中的改变”尤其涉及其中FGFR3基因发生改变(例如，通过突变或融合)的样本。例如，此类突变可以存在于FGFR3基因的外显子7、10和15中。最常观察到的突变之一是外显子7中的S249C(Tomlinson et al.，2007)。另一种常见的FGFR3的改变是FGFR3-TACC3融合，如Costa et al.(2016)所述，其内容通过引用并入本文，或Lasorella et al.(2017)所述，其内容通过引用并入本文。
如图所示，通常情况下，以下FGFR状态已确定为对(i)抗癌剂，如免疫肿瘤药物，或(ii)FGFR抑制剂治疗提供合适的预后价值。表4给出一些示例：
表4：根据本发明的不同预后结果
因此，如果FGFR2上调或过表达，则各自患者对于用抗癌剂的治疗预后良好。因此，应选择的治疗模式是抗癌剂，如免疫肿瘤药物。
如果FGFR3上调或过表达，应选择的治疗模式是FGFR抑制剂。同样，如果FGFR2下调或低表达，并且FGFR3发生改变，则应选择的治疗模式为FGFR抑制剂。
如果FGFR2和FGFR3下调或低表达，则各自患者对于用抗癌剂的治疗预后良好。因此，应选择的治疗模式是抗癌剂，如免疫肿瘤药物。
特别是，如果FGFR3下调或低表达，这可以导致免疫浸润增加，这反过来表明用免疫肿瘤药物(如免疫检查点抑制剂(见下文))治疗可以成功。
根据本发明的一个或多个实施方案，用二氧化硅包被的磁性颗粒和离液盐处理样本，以用于在步骤a)中确定之前纯化所述样本中所含的核酸。
根据本发明的一个或多个实施方案，抗癌剂包括至少一种化疗剂。
根据本发明的一个或多个实施方案，抗癌剂包括免疫检查点抑制剂。
检查点抑制剂是一种靶向免疫检查点(即刺激或抑制其作用的免疫系统的关键调节因子)的癌症免疫疗法药物形式。肿瘤可以利用这些检查点来保护自己免受免疫系统的攻击。检查点疗法可以阻断抑制性检查点，恢复免疫系统功能。
根据本发明的一个或多个实施方案，免疫检查点抑制剂是选自以下的至少一种：
·PD-1抑制剂
·PD-L1抑制剂
·CTLA-4抑制剂
·LAG 3抑制剂
·TIM3抑制剂，和/或
·OX40抑制剂
根据本发明的一个或多个实施方案，免疫检查点抑制剂是选自以下的至少一种：
·抗体，
·修饰的抗体形式，
·保留靶结合特性的抗体衍生物或片段
·基于抗体的结合蛋白，
·寡肽结合剂和/或
·抗体模拟物。
“抗体”，也称为“免疫球蛋白”(Ig)，通常包括4条多肽链，2条重链(H)和2条轻链(L)，并因此是多聚蛋白，或其等效的Ig同系物(例如，骆驼纳米抗体，其仅包括重链、可以来源于重链或轻链的单结构域抗体(dAb))；包括全长功能性突变、变体或其衍生物(包括但不限于鼠的、嵌合的、人源化的和全人的抗体，其保留Ig分子的基本表位结合特征，且包括双重特异性、双特异性、多特异性和双可变结构域免疫球蛋白；免疫球蛋白分子可以是任何类别(例如IgG、IgE、IgM、IgD、IgA和IgY)或亚类(例如IgG1、IgG2、IgG3、IgG4、IgA1和IgA2)和同种异型。
如本文使用的“基于抗体的结合蛋白”可以代表在其他非免疫球蛋白或非抗体衍生组分背景下含有至少一个抗体衍生的VH、VL或CH免疫球蛋白结构域的任何蛋白。此类基于抗体的蛋白包括但不限于(i)结合蛋白的Fc融合蛋白，包括具有免疫球蛋白CH结构域全部或部分的受体或受体组分，(ii)结合蛋白，其中VH和/或VL结构域与替代分子支架偶联，或(iii)分子，其中免疫球蛋白VH和/或VL和/或CH结构域以通常不在天然存在的抗体或抗体片段中发现的方式组合和/或组装。
本文使用的“抗体衍生物或片段”涉及包括至少一条多肽链的分子，该多肽链衍生于非全长抗体，包括但不限于(i)Fab片段，其为单价片段，由可变轻链(VL)、可变重链(VH)、恒定轻链(CL)和恒定重链1(CH1)结构域组成；(ii)F(ab')2片段，其为二价片段，包括铰链区二硫键连接的两个Fab片段；(iii)Fab(Fd)片段的重链部分，其由VH和CH1结构域组成；(iv)可变片段(Fv)片段，其由抗体单臂的VL和VH结构域组成；(v)结构域抗体(dAb)片段，其包括单个可变结构域；(vi)分离的互补决定区(CDR)；(vii)单链Fv片段(scFv)；(viii)双体，其是二价、双特异性抗体，其中VH和VL结构域在单一多肽链上表达，但使用的连接子太短无法在同一链上的两个结构域之间配对，从而迫使结构域与另一条链的互补结构域配对，并产生两个抗原结合位点；和(ix)线性抗体，其包括一对串联Fv片段(VH-CH1-VH-CH1)，其与互补轻链多肽一起形成一对抗原结合区域；和(x)免疫球蛋白重链和/或轻链的其他非全长部分，或其突变体、变体或衍生物，单独或任何组合。在任何情况下，所述衍生物或片段均保留靶结合特性。
如本文使用的，术语“修饰的抗体形式”涵盖抗体药物偶联物、聚亚烃氧化物修饰的scFv、单体、双体、骆驼抗体、结构域抗体、双特异性或三特异性抗体、IgA或通过J链和分泌性组分连接的两种IgG结构、鲨鱼抗体、新世界灵长类动物框架+非新世界灵长类动物CDR、去除铰链区的IgG4抗体、在CH3结构域中工程化另外两个结合位点的IgG、Fc区改变以增强Fcγ受体亲和力的抗体、包括CH3+VL+VH的二聚化构建体等。
如本文使用的，术语“抗体模拟物”是指不属于免疫球蛋白家族的蛋白，甚至是非蛋白，如适配子或合成聚合物。一些类型具有抗体样β折叠结构。“抗体模拟物”或“替代支架”相对于抗体的潜在优点是溶解度更好、组织渗透性更高、对热和酶的稳定性更高以及生产成本相对较低。
一些抗体模拟物可以在大文库中提供，其提供针对每个可设想靶的特异性结合候选物。就像抗体一样，通过使用高通量筛选(HTS)技术以及成熟的展示技术，可以开发靶向特异性抗体模拟物，就像噬菌体展示、细菌展示、酵母或哺乳动物展示一样。目前开发的抗体模拟物涵盖，例如，锚蛋白重复蛋白(称为DARPin)、C型凝集素、金黄色葡萄球菌的A结构域蛋白、转铁蛋白、脂钙蛋白、纤连蛋白的第10个III型结构域、Kunitz结构域蛋白酶抑制剂、泛素衍生的结合物(称为affilin)、γ晶体蛋白衍生的结合物、半胱氨酸结或打结素、基于硫氧还蛋白A支架的结合物、SH-3结构域、斯塔都体(stradobody)、通过二硫键和Ca2+稳定的膜受体的“A结构域”、基于CTLA4的化合物、Fyn SH3和适配子(与特定靶分子结合的肽分子)。
根据本发明的一个或多个实施方案，免疫检查点抑制剂是选自表5所示的至少一种。
表5：免疫检查点抑制剂
DART，双亲和重新靶向；mAb，单克隆抗体；NA，不适用。
FGFR抑制剂干扰FGFR信号传导，并因此提供了影响肿瘤存活的不同模式。它们允许在人癌细胞中增加肿瘤对紫杉醇、依托泊苷等常规抗癌药物的敏感性，并从而增强抗凋亡潜力。此外，在乳腺癌常用VEGFR-2治疗后，基于FGF2上调的自分泌FGF信号传导，FGF信号传导抑制显著减少血运重建(作用于癌症、血管生成的标志之一)，并降低人类肿瘤中的肿瘤负荷。通过此类方法，FGFR抑制剂可以与疗法协同作用，通过消除未来复发的潜在途径来切断癌症克隆的复发。
此外，由于靶向EGFR或VEGFR的疗法后FGFR激活的次要亚群的克隆演化，FGFR抑制剂可以对复发性肿瘤有效。由于FGFR抑制剂克服人类癌症中的耐药性有多种作用机制，FGFR靶向疗法是难治性癌症治疗的一种有前景的策略。
根据本发明的一个或多个实施方案，FGFR抑制剂是FGFR酪氨酸激酶抑制剂。酪氨酸激酶抑制剂(TKI)是一种抑制酪氨酸激酶的药物。酪氨酸激酶是负责通过信号转导级联激活许多蛋白的酶。通常，它们形成跨膜受体的细胞内部分，并在与细胞外配体结合时被激活。酪氨酸激酶通过向蛋白添加磷酸基团(磷酸化)激活蛋白，这是TKI抑制的步骤。TKI通常用作抗癌药物。例如，它们显著改善慢性粒细胞白血病的结局。
根据本发明的一个或多个实施方案，FGFR抑制剂是选自如下表6所示的至少一种：
表6：FGFR抑制剂
泛FGFR＝FGFR1、FGFR2、FGFR3和FGFR4
根据本发明的另一个方面，提供了一种寡核苷酸，其包括至少一个能够与以下杂交的核苷酸序列：
a)编码FGFR1、FGFR2、FGFR3或FGFR4中任何一个的核酸分子或改变的FGFR基因，或
b)编码FGFR1、FGFR2、FGFR3或FGFR4中任何一个或其同种型或改变的FGFR的mRNA，
其中寡核苷酸选自以下：
-扩增引物(正向和/或反向)
-标记的探针，和/或
-底物结合的探针。
根据本发明的一个或多个实施方案，提供所述寡核苷酸，用于制备用于根据上述说明书所述的方法的试剂盒。
优选地，提供一组(i)正向扩增引物，(ii)反向扩增引物和(iii)探针(标记的和/或底物结合的)。
除此之外，任选地，提供包括至少一个核苷酸序列的寡核苷酸，其能够与以下杂交：
a)编码参考基因或管家基因的核酸分子，或
b)编码参考蛋白或管家蛋白的mRNA，
其中寡核苷酸选自以下：
-扩增引物(正向和/或反向)
-标记的探针，和/或
-底物结合探针。
优选地，提供一组(i)正向扩增引物，(ii)反向扩增引物和(iii)探针(标记的和/或底物结合的)以用于该目的。优选地，参考基因或管家基因选自CALM2、B2M和/或RPL37A。
注意的是，一些合适的引物(正向和/或反向)和探针显示在本文的序列表中。
根据本发明的一个或多个实施方案，包括上述说明书中所述的至少一种寡核苷酸的试剂盒。
根据本发明的一个或多个实施方案，试剂盒包括至少一组反向引物、正向引物加上任选地探针，如上所述。
根据本发明的一个或多个实施方案，试剂盒包括：
a)能够与编码FGFR2的核酸分子杂交的正向/反向引物组，加上任选地合适探针，以及
b)能够与编码FGFR3的核酸分子杂交的正向/反向引物组，加上任选地合适探针。
此类引物和任选地探针的示例见序列表，SEQ ID NO 25-57(FGFR2)和SEQ IDNO58-75(FGFR3)。
基于本发明的启示和本文公开的序列信息，以及在显示FGFR2和FGFR3基因组和mRNA序列的公共数据库中，本领域技术人员可以找到同样合适的替代引物和探针，而无需任何创造性的活动。因此，此类替代物也应涵盖在本申请范围内。
根据本发明的一个或多个实施方案，试剂盒还包括能够检测FGFR3-TACC3融合蛋白存在的引物组。
根据本发明的一个或多个实施方案，试剂盒包括：
a)能够与编码FGFR2的核酸分子杂交的正向/反向引物组，和
b)能够检测FGFR3-TACC3融合蛋白存在的引物组。
根据本发明的一个或多个实施方案，能够检测FGFR3-TACC3融合蛋白存在的引物组包括：
a)能够与位于FGFR3和TACC3之间融合位点的N端的FGFR3外显子中的核酸分子杂交的正向引物，和能够与位于FGFR3和TACC3之间融合位点的C端的TACC3外显子中的核酸分子杂交的反向引物，
b)能够与编码FGFR3 N端区域的核酸分子杂交的正向引物和能够与编码FGFR3N端区域的核酸分子杂交的反向引物，加上能够与编码FGFR3 C端区域的核酸分子杂交的正向引物和能够与编码FGFR3 C端区域的核酸分子杂交的反向引物，
c)能够与编码TACC3的C端区域的核酸分子杂交的正向引物和能够与编码TACC3的N端区域的核酸分子杂交的反向引物，加上能够与编码TACC3的N端区域的核酸分子杂交的正向引物和能够与编码TACC3的N端区域的核酸分子杂交的反向引物，和/或
d)能够与位于FGFR3和TACC3之间融合位点的N端的FGFR3外显子中的核酸分子杂交的正向引物，和能够与位于FGFR3和TACC3之间融合位点的C端的FGFR3外显子中的核酸分子杂交的反向引物。
选项a)用于测量所定义的FGFR3-TACC3融合蛋白的表达。
选项b)用于测量FGFR3 N端和C端表达之间的Δ。当FGFR3-TACC3融合物存在时，FGFR3 C端的表达应小于FGFR3 N端的表达。通过这一实施方案，可以测量不同的FGFR3-TACC3融合蛋白变体。
选项c)用于测量TACC3 N端和C端表达之间的Δ。当FGFR3-TACC3融合物存在时，TACC3 C端的表达高于TACC3 N端的表达。通过这一实施方案，可以测量不同的FGFR3-TACC3融合蛋白变体。
选项d)用于测量位于FGFR3和TACC3之间融合位点的N端的FGFR3外显子和位于FGFR3和TACC3之间融合位点的C端的FGFR3外显子的表达之间的Δ。当FGFR3-TACC3融合物存在时，位于N端的FGFR3外显子的表达应高于位于C端的FGFR3外显子的表达。
选项a)至d)对应于图8A-D所示的实施方案。
TACC3和FGFR3的外显子结构如图12和13所示。TACC3基因由跨越23.6kb的16个经过验证的外显子组成。FGFR3基因由跨越16.5Kb的19个外显子组成，其中外显子1在人类中是未知的。基于这一信息，本领域技术人员能够在阅读本发明的启示时设计引物和任选地探针。
在选项a)的一个实施方案中，正向引物能够与FGFR3外显子1-18中的核酸分子杂交，以及反向引物能够与TACC3外显子11-16中的核酸分子杂交。
选项a)的此类引物和任选地探针示例示于序列表，SEQ ID NO 149和150。
选项b)的此类引物和任选地探针示例示于序列表，SEQ ID NO 153、154、157和158。
选项c)的此类引物和任选地探针示例示于序列表，SEQ ID NO 155、156、159和160。
在选项d)的一个实施方案中，正向引物能够与FGFR3外显子1-17中的核酸分子杂交和反向引物能够与FGFR3外显子18或更高中的核酸分子杂交。
选项d)的此类引物和任选地探针示例示于序列表，SEQ ID NO 161-166。
如在其他地方所讨论的，文献中描述FGFR3-TACC3融合蛋白。在一种情况下，如图8所示，融合包括N->C方向的FGFR3外显子1-17和TACC3外显子11-16。如上所示的引物试剂盒作为选项a)和d)的优选实施方案，已被设计为此类融合结构的基础之一。但是，在融合结构不同的情况下，可以或必须对引物和任选地探针进行修饰。
基于本发明的启示，和本文公开的序列信息，和在显示FGFR3和TACC3的基因组和mRNA序列的公共数据库中，以及替代FGFR3-TACC3融合蛋白结构的公共可用性(参见本文图8和14，以及Kurobe et al(2016)，其内容通过引用并入本文)，本领域技术人员可以找到同样合适的替代引物和探针，而无需任何创造性的活动。因此，此类替代方法也应涵盖在本申请范围内。
根据本发明的一个或多个实施方案，本发明的试剂盒包括引物/探针组，其包括：
a)正向引物和反向引物，和任选地探针，正如表1所示，和正向引物和反向引物，和任选地探针，正如表2所示，
b)a)的引物和任选地探针，和至少正向引物和反向引物，和任选地探针，正如表3所示，
c)正向引物和反向引物，和任选地探针，正如表1所示，和至少正向引物和反向引物，和任选地探针，正如表3所示。
任选地，试剂盒还包括一组反向引物、正向引物加上任选地探针，用于检测参考基因或管家基因，如上所述。优选地，所述基因选自CALM2、B2M和/或RPL37A。
如本文使用的，术语“改变的FGFR基因”例如涉及发生改变(例如，通过突变或融合)的FGFR3基因。例如，此类突变可以存在于FGFR3基因的外显子7、10和15中。最常观察到的突变之一是外显子7中的S249C(Tomlinson et al.，2007)。另一种常见的FGFR3的改变是FGFR3-TACC3融合，如Costa et al.(2016)所述，其内容通过引用并入本文。
如本文使用的，术语“改变的FGFR”涉及依赖于此类改变FGFR基因的基因产物，即蛋白或mRNNA。
根据本发明的一个或多个实施方案，试剂盒包括标记的探针，其用一个或多个荧光分子、发光分子、放射性分子、酶分子和/或猝灭分子标记。
在本发明背景下使用的一种典型探针类型是所谓的TaqMan探针。TaqMan探针由共价连接在寡核苷酸探针5’端的荧光团和3’端的猝灭剂组成。有几种不同的荧光团(例如6-羧基荧光素，缩写词：FAM，或四氯荧光素，缩写词：TET)和猝灭剂(例如四甲基罗丹明，缩写词：TAMRA)是可用的。当由循环仪的光源通过
共振能量转移(FRET)激发时，猝灭剂分子猝灭荧光团发出的荧光。只要荧光团和猝灭剂在附近，猝灭就会抑制任何荧光信号。TaqMan探针的设计使其在特定引物组扩增的DNA区域内退火。(与示意图不同，探针与单链DNA结合。)TaqMan探针可以与小沟结合剂(MGB)部分，二氢环吡咯并吲哚三肽(DPI3)缀合，以增加其与靶序列的结合亲和力；由于范德华力的稳定性增加，MGB缀合的探针具有更高的熔解温度(Tm)。当Taq聚合酶延伸引物并合成新生链时(再次，在单链模板上，但方向与示意图中所示相反，即从互补链的3'至5')，Taq聚合酶的5'至3'核酸外切酶活性降解退火至模板的探针。探针的降解将荧光团从其中释放出来，并打破与猝灭剂的紧密接近，从而解除猝灭效应并使荧光团产生荧光。因此，在定量PCR热循环仪中检测到的荧光与释放的荧光团和PCR中存在的DNA模板量成正比。
根据本发明的一个或多个实施方案，提供根据上述说明书的寡核苷酸或试剂盒在将患有尿路上皮癌或膀胱癌或具有发展尿路上皮癌或膀胱癌的风险的患者的样本分类为至少两种分类之一的方法中的用途。
实施例
虽然在附图和前面的说明书中对本发明进行详细的说明和描述，但是此类说明和描述应当被认为是说明性或示范性的，并且不具有限制性；本发明不限于所公开的实施方案。根据对附图、所公开内容和随附权利要求的研究，实施所要求发明的本领域技术人员可以理解和实现所公开实施方案的其他变体。在权利要求书中，词语“包括”并不排除其他要素或步骤，且非限定性冠词“一(a)”或“一(an)”并不排除复数。仅仅是某些量度在相互不同的从属权利要求中被引用的事实并不表明这些量度的组合不能被用来取得优点。本权利要求中的任何参考符号不应解释为限制范围。
本文公开的所有氨基酸序列均显示为从N端至C端；本文公开的所有核酸序列均显示为5'->3'。
材料和方法
分析的患者的临床状态和生存数据
在本研究中，72例福尔马林固定、石蜡包埋(FFPE)的晚期尿路上皮癌样本获自5家病理机构(采集日期为2016年至2018年)。所有标本根据2010年TNM分类按病理分期重新评价，并按常见分级系统(WHO 1974,AH,ME)分级。72例患者(男性52例[72％]；女性20例[28％])用免疫疗法治疗，49例(69％)患者接受PD1抑制剂(纳武利尤单抗、帕博利珠单抗)，以及22例(31％)接受PDL1抑制剂(阿替丽珠单抗)。免疫疗法开始后的中位随访时间为7.1个月(范围：1-25个月)。50例患者(69％)的肿瘤起源于膀胱，以及22例患者(31％)的肿瘤位于上尿路(输尿管和/或肾盂)。组织病理学中的TNM分期(膀胱切除术、肾输尿管切除术、初诊)显示52例患者(73％)为T3或T4期肿瘤。关于全身化疗，4例患者(6％)接受新辅助化疗，以及67例患者(94％)未接受新辅助化疗。在辅助治疗中，20例(28％)接受辅助化疗，以及52例患者(72％)未接受辅助化疗。组织病理学数据和手术总结见下表6。
表6：患者队列的组织学数据、肿瘤位置和手术
Kaplan Meier分析中，男性和女性患者的总生存期相当(图2A)。用PD1抑制剂(纳武利尤单抗/帕博利珠单抗)治疗的患者与用PDL1抑制剂(阿替丽珠单抗)治疗的患者相比也是如此。同样，在用IO疗法治疗的这些患者组中未观察到显著的生存差异。在KaplanMeier分析中，IO疗法下晚期膀胱肿瘤和晚期上尿路肿瘤患者的总生存期相当(数据未显示)。具有远处转移的患者(n＝19)的总生存期(12个月后生存概率25.3％)显著短于无远处转移的患者(n＝40；12个月后生存概率59.2％，p＝0.0048，(数据未显示))。
用于SNaPShot测序的DNA分离
使用自动化程序(Promega Maxwell,Promega,Wisconsin,USA)，从福尔马林固定石蜡包埋组织(FFPE)中分离DNA。一般而言，每例患者肿瘤使用5个10μm FFPE切片，其中肿瘤含量至少为50％。简言之，切片用二甲苯脱蜡，用无RNAse乙醇(100％，96％，70％)再水化。将分馏的肿瘤组织混悬于300μl孵育缓冲液(Promega)中，在80℃的恒温振荡器(350rpm)上预孵育10分钟，并用蛋白酶K(Promega)在56℃下处理过夜(550rpm)。然后使用Promega DNA纯化试剂盒(Promega,Wisconsin,USA)从裂解物中分离DNA。
FGFR3-SNaPshot的突变分析
如前所述，通过SNaPshot PCR进行FGFR3突变分析(参见van Oers 2007，其内容通过引用并入本文)。简言之，FGFR3基因的三个区域，包括在膀胱癌中发现的所有FGFR3突变(见van Rhijn 2002，其内容通过引用并入本文)，通过多重聚合酶链式反应(PCR)同时进行扩增。去除过量后引物和dNTP，检测9个FGFR3突变的8个SNaPshot引物退火到PCR产物并用标记的双脱氧核苷酸进行延伸。在自动测序仪上分析这些延伸的引物，而在结合的核苷酸上的标记表明是否存在突变。所有突变均通过第二和独立的SNaPshot分析进行验证。
FGFR融合基因的筛查和验证
如前所述，建立了靶向FGFR2和FGFR3的3'序列的通用RQ-PCR检测，其在已知融合基因中保留或缺失并因此可以过表达(Erben 2010)。在
实时PCR系统(Applied
USA)中，使用
快速高级Master Mix(Applied
USA)进行FGFR2和FGFR3的定量PCR(qPCR)。使用Superscript
逆转录酶试剂盒(Invitrogen,USA)和各研究基因特异性的反向引物，对FFPE组织样本中的RNA进行cDNA的合成。以下方案用于qPCR：95℃下20s，然后95℃下每3s 40个循环，以及60℃下30s。所有测量一式两份。使用FGFR3-TACC3融合物的特异性PCR，分析了显示差异(超过1个CT)和/或高FGFR3和FGFR2表达的样本，并通过下一代测序进一步进行验证。通过使用扩增引物的双向Sanger测序，确认单次或巢式PCR中FGFR3-TACC3融合基因阳性样本的PCR产物。
下一代测序
使用INVIEW Oncopanel一体化(Konstanz,Germany)，在GATC Biotech分析FFPE样本中的潜在相关基因改变，这是一种使用Agilent Sure select技术的基于杂交的靶捕获下一代测序方法。Panel在新一代Illumina平台上覆盖了597个癌症相关基因的外显子和启动子区域(https://www.eurofinsgenomics.eu/en/next-generation-sequencing/ngs-built-for-you/inview-panel/inview-oncopanel-all-in-one/)。对肉眼可见的健康尿路上皮组织进行大体解剖，并作为拷贝数分析的对照。根据生产商的说明书，使用基于微珠的系统(XTRACT试剂盒，STRATIFYER Molecular Pathology GmbH,Germany)提取核酸，并用于测序和基因表达分析。
来自FFPE组织的RNA分离，以用于经RT-qPCR的mRNA评估和定量
使用10μm切片从FFPE组织中提取RNA，这些切片通过市售基于微珠的提取方法进行全自动处理(XTRACT试剂盒；STRATIFYER Molecular Pathology GmbH,Cologne,Germany)。使用100μL洗脱缓冲液洗脱RNA，分析RNA洗脱液。如前所述，使用基于基因特异性
的试验，应用RT-qPCR对FGFR 1-4mRNA以及管家基因表达进行相对定量(Eckstein2018,Eckstein 2018,Worst 2018)。每份患者样本或对照品一式三份。根据以下方案，在罗氏光循环仪LC480(Roche,Germany)上运行该实验：50℃下5min，95℃下20s，然后95℃下15s的40个循环，以及60℃下60s。应用40个扩增循环，而每个样本的3个标记物和1个参考基因的循环定量阈值(Ct)值估计为一式三份测量的平均值。从管家基因的CT值中减去靶基因的CT值(ΔCT)，对ΔCT值进行归一化，并将其设定为正在进行的循环背景下(例如40个循环)。
统计学分析
所有p值都是双侧计算的，并且<0.05的值被认为是显著的。通过单变量Kaplan-Meier回归进行生存分析，并使用对数秩检验显著性。如果检验显示显著性水平低于0.05，则认为结果具有显著性。通过非参数检验(Wilcoxon秩和检验、Kruskal-Wallis检验)对数值连续变量进行统计分析。采用spearman等级相关进行连续变量的相关性分析。所有统计分析均通过GraphPad Prism 7.2(GraphPad Software Inc.,La Jolla,California,USA)以及JMP SAS 13.2(SAS,Cary,North Carolina,USA)进行。
患者队列
鉴定在多个中心(n＝5)用临床常规抗PD-1/抗PD-L1免疫肿瘤药物作为一线、二线和三线治疗的一部分治疗患者，并产生各自的原发性和转移性肿瘤组织选择的样本选择。
引物/探针组
下文显示了具有用于执行本发明的可选探针的PCR引物组。应该注意的是，本领域技术人员能够在未指定的情况下选择合适的探针。
表7：具有针对的FGFR2可选探针的引物组的SEQ ID NO
| 正向 | 探针 | 反向 |
| 25 | 26 | 27 |
| 28 | 29 | 30 |
| 31 | 32 | 33 |
| 34 | 35 | 36 |
| 37 | 38 | 39 |
| 40 | 41 | 42 |
| 43 | 44 | 45 |
| 46 | 47 | 48 |
| 49 | 50 | 51 |
| 52 | 53 | 54 |
| 55 | 56 | 57 |
表8：具有针对FGFR3的可选探针的引物组的SEQ ID NO
表9：具有针对FGFR3-TACC3的可选探针的引物组的SEQ ID NO
参考文献
Kozera and Rapacz,Reference genes in real-time PCR,J Appl Genet.2013；54(4):391–406
Tomlinson DC et al,Knockdown by shRNA identifies S249C mutant FGFR3as a potential therapeutic target in bladder cancer.Oncogene.2007Aug 30；26(40):5889–5899
Costa R et al,FGFR3-TACC3 fusion in solid tumors:minireview.Oncotarget.2016 Aug 23；7(34):55924-55938
Lasorella Aet al.,FGFR-TACC gene fusions in human glioma.NeuroOncol.2017 Apr；19(4):475–483
van Oers JM,et al,FGFR3 mutations and a normal CK20 staining patterndefine low-grade noninvasive urothelial bladder tumours.Eur Urol.2007 Sep；52(3):760-8.
van Rhijn BW,et al:Novel fibroblast growth factor receptor 3(FGFR3)mutations in bladder cancer previously identified in non-lethal skeletaldisorders.Eur J Hum Genet.2002 Dec；10(12):819-24.
Kurobe M et al.(2016)Development of RNA-FISH Assay for Detection ofOncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples.PLoS ONE 11(12):e0165109.doi:10.1371/journal.pone.0165109
序列
以下序列构成本申请公开的一部分。该申请还提供了WIPO ST 25兼容的电子序列表。为避免疑义，如果下表中的序列与电子序列表中的序列之间存在差异，则认为本表中的序列正确。
序列表
<110> 斯卓蒂费尔分子病理学有限责任公司
<120> 基于确定FGFR的分类样本的方法
<130> SD44528
<160> 166
<170> PatentIn version 3.5
<210> 1
<211> 18
<212> DNA
<213> Homo sapiens
<400> 1
atgcaggggc gcaaacgc 18
<210> 2
<211> 26
<212> DNA
<213> Homo sapiens
<400> 2
ctgtaggaag agaagggcag agcgcc 26
<210> 3
<211> 16
<212> DNA
<213> Homo sapiens
<400> 3
gagcgggccg agctgt 16
<210> 4
<211> 21
<212> DNA
<213> Homo sapiens
<400> 4
ccacctgctg gtcatcactg t 21
<210> 5
<211> 27
<212> DNA
<213> Homo sapiens
<400> 5
ctcactaagt ggattctggc tcccccg 27
<210> 6
<211> 23
<212> DNA
<213> Homo sapiens
<400> 6
ggagtggtag tttgagccat gag 23
<210> 7
<211> 24
<212> DNA
<213> Homo sapiens
<400> 7
gcacaggagt gtctttcctt gtaa 24
<210> 8
<211> 31
<212> DNA
<213> Homo sapiens
<400> 8
cagtgatgat aatttctgcc ttggccctac c 31
<210> 9
<211> 22
<212> DNA
<213> Homo sapiens
<400> 9
cccttcacac aacattgctt ca 22
<210> 10
<211> 32
<212> DNA
<213> Homo sapiens
<400> 10
ttactgctaa atacaaaaga aagttcaata tg 32
<210> 11
<211> 30
<212> DNA
<213> Homo sapiens
<400> 11
attgctgctt taaatttctg agctagggat 30
<210> 12
<211> 30
<212> DNA
<213> Homo sapiens
<400> 12
gtgctattta cagagagaaa caaagagaat 30
<210> 13
<211> 20
<212> DNA
<213> Homo sapiens
<400> 13
caaaccgtat gcccgtagct 20
<210> 14
<211> 28
<212> DNA
<213> Homo sapiens
<400> 14
tggacatccc cagaaaagat ggaaaaga 28
<210> 15
<211> 24
<212> DNA
<213> Homo sapiens
<400> 15
aagggcattt gaacttcact gtct 24
<210> 16
<211> 21
<212> DNA
<213> Homo sapiens
<400> 16
ggctgccaag acagtgaagt t 21
<210> 17
<211> 23
<212> DNA
<213> Homo sapiens
<400> 17
aaatgccctt ccagtgggac ccc 23
<210> 18
<211> 20
<212> DNA
<213> Homo sapiens
<400> 18
tttttcaacc agcgcagtgt 20
<210> 19
<211> 24
<212> DNA
<213> Homo sapiens
<400> 19
tctatcggac tctcccatca ctct 24
<210> 20
<211> 25
<212> DNA
<213> Homo sapiens
<400> 20
atggttgacc gttctggaag ccctg 25
<210> 21
<211> 18
<212> DNA
<213> Homo sapiens
<400> 21
tcactgccgg cctctctt 18
<210> 22
<211> 24
<212> DNA
<213> Homo sapiens
<400> 22
aattcaaacc tgaccacaga attg 24
<210> 23
<211> 25
<212> DNA
<213> Homo sapiens
<400> 23
aggctacaag gtccgttatg ccacc 25
<210> 24
<211> 24
<212> DNA
<213> Homo sapiens
<400> 24
caccacagag tccattatga tgct 24
<210> 25
<211> 19
<212> DNA
<213> Homo sapiens
<400> 25
aagcaggagc atcgcattg 19
<210> 26
<211> 28
<212> DNA
<213> Homo sapiens
<400> 26
aggctacaag gtacgaaacc agcactgg 28
<210> 27
<211> 21
<212> DNA
<213> Homo sapiens
<400> 27
cagatgggac cacactttcc a 21
<210> 28
<211> 27
<212> DNA
<213> Homo sapiens
<400> 28
cagaagccct gtttgataga gtataca 27
<210> 29
<211> 26
<212> DNA
<213> Homo sapiens
<400> 29
cagagtgatg tctggtcctt cggggt 26
<210> 30
<211> 27
<212> DNA
<213> Homo sapiens
<400> 30
cctaaagtga agatctccca cattaac 27
<210> 31
<211> 27
<212> DNA
<213> Homo sapiens
<400> 31
gttaatgtgg gagatcttca ctttagg 27
<210> 32
<211> 24
<212> DNA
<213> Homo sapiens
<400> 32
ctacccaggg attcccgtgg agga 24
<210> 33
<211> 23
<212> DNA
<213> Homo sapiens
<400> 33
tccttccttc agcagcttaa aaa 23
<210> 34
<211> 26
<212> DNA
<213> Homo sapiens
<400> 34
gaagacttgg atcgaattct cactct 26
<210> 35
<211> 35
<212> DNA
<213> Homo sapiens
<400> 35
acaaccaatg aggaatactt ggacctcagc caacc 35
<210> 36
<211> 28
<212> DNA
<213> Homo sapiens
<400> 36
tgtcagggta actaggtgaa tactgttc 28
<210> 37
<211> 21
<212> DNA
<213> Homo sapiens
<400> 37
tcagccaacc tctcgaacag t 21
<210> 38
<211> 29
<212> DNA
<213> Homo sapiens
<400> 38
ttcacctagt taccctgaca caagaagtt 29
<210> 39
<211> 26
<212> DNA
<213> Homo sapiens
<400> 39
aaacagaatc atctcctgaa gaacaa 26
<210> 40
<211> 21
<212> DNA
<213> Homo sapiens
<400> 40
cttggtgtca tgcacctacc a 21
<210> 41
<211> 30
<212> DNA
<213> Homo sapiens
<400> 41
agtacttggc ttcccaaaaa tgtattcatc 30
<210> 42
<211> 25
<212> DNA
<213> Homo sapiens
<400> 42
aaaacatttc tggctgctaa atctc 25
<210> 43
<211> 16
<212> DNA
<213> Homo sapiens
<400> 43
cccaccgcag gctgaa 16
<210> 44
<211> 22
<212> DNA
<213> Homo sapiens
<400> 44
attgcgcgta gtccatgccc gt 22
<210> 45
<211> 23
<212> DNA
<213> Homo sapiens
<400> 45
ttaatcccat ctgcacactt cct 23
<210> 46
<211> 16
<212> DNA
<213> Homo sapiens
<400> 46
cccggccctc cttcag 16
<210> 47
<211> 31
<212> DNA
<213> Homo sapiens
<400> 47
ttgaggatac cacattagag ccagaagagc c 31
<210> 48
<211> 26
<212> DNA
<213> Homo sapiens
<400> 48
ctggttgaga gatttggtat ttggtt 26
<210> 49
<211> 19
<212> DNA
<213> Homo sapiens
<400> 49
ggaacccaat gccaaccat 19
<210> 50
<211> 21
<212> DNA
<213> Homo sapiens
<400> 50
atgcgatgct cctgcttaaa c 21
<210> 51
<211> 22
<212> DNA
<213> Homo sapiens
<400> 51
cggtggctga aaaacgggaa gg 22
<210> 52
<211> 19
<212> DNA
<213> Homo sapiens
<400> 52
gcgcctggaa gagaaaagg 19
<210> 53
<211> 26
<212> DNA
<213> Homo sapiens
<400> 53
attacagctt ccccagacta cctgga 26
<210> 54
<211> 24
<212> DNA
<213> Homo sapiens
<400> 54
gacccctatg cagtaaatgg ctat 24
<210> 55
<211> 29
<212> DNA
<213> Homo sapiens
<400> 55
gattgggaaa cacaagaata tcataaatc 29
<210> 56
<211> 30
<212> DNA
<213> Homo sapiens
<400> 56
cacaggatgg gcctctctat gtcatagttg 30
<210> 57
<211> 28
<212> DNA
<213> Homo sapiens
<400> 57
gaacacggtt aatgtcatag gagtactc 28
<210> 58
<211> 23
<212> DNA
<213> Homo sapiens
<400> 58
gccttgtttg accgagtcta cac 23
<210> 59
<211> 23
<212> DNA
<213> Homo sapiens
<400> 59
agagtgacgt ctggtccttt ggg 23
<210> 60
<211> 19
<212> DNA
<213> Homo sapiens
<400> 60
cccccagcgt gaagatctc 19
<210> 61
<211> 19
<212> DNA
<213> Homo sapiens
<400> 61
agcgcgtact gtgccactt 19
<210> 62
<211> 23
<212> DNA
<213> Homo sapiens
<400> 62
agtgtgcggg tgacagacgc tcc 23
<210> 63
<211> 20
<212> DNA
<213> Homo sapiens
<400> 63
ctccccgtct tcgtcatctc 20
<210> 64
<211> 16
<212> DNA
<213> Homo sapiens
<400> 64
tgaggacgcc gcggcc 16
<210> 65
<211> 22
<212> DNA
<213> Homo sapiens
<400> 65
cccgccatgg gcgcccctgc ct 22
<210> 66
<211> 16
<212> DNA
<213> Homo sapiens
<400> 66
gccacgcaga gcgcga 16
<210> 67
<211> 17
<212> DNA
<213> Homo sapiens
<400> 67
atggggccca ctgtctg 17
<210> 68
<211> 21
<212> DNA
<213> Homo sapiens
<400> 68
cctggtgggg ccccagcggc t 21
<210> 69
<211> 20
<212> DNA
<213> Homo sapiens
<400> 69
gtgggaggca ttcagcacct 20
<210> 70
<211> 19
<212> DNA
<213> Homo sapiens
<400> 70
tgactggtgc tgcagcacc 19
<210> 71
<211> 24
<212> DNA
<213> Homo sapiens
<400> 71
cctttgttct ggggggaccc agtg 24
<210> 72
<211> 21
<212> DNA
<213> Homo sapiens
<400> 72
ggcccactta cattctgcac t 21
<210> 73
<211> 19
<212> DNA
<213> Homo sapiens
<400> 73
cccaccgtgc acaagatct 19
<210> 74
<211> 26
<212> DNA
<213> Homo sapiens
<400> 74
agcgacaggt gtccctggag tccaac 26
<210> 75
<211> 19
<212> DNA
<213> Homo sapiens
<400> 75
atgcgcacca gtggtgtgt 19
<210> 76
<211> 18
<212> DNA
<213> Homo sapiens
<400> 76
acaggaggtg ggccgctc 18
<210> 77
<211> 24
<212> DNA
<213> Homo sapiens
<400> 77
tcgcgggtac attcctcgct cccg 24
<210> 78
<211> 24
<212> DNA
<213> Homo sapiens
<400> 78
tcgcgggtac attcctcgct cccg 24
<210> 79
<211> 20
<212> DNA
<213> Homo sapiens
<400> 79
agcagcaaga gcaggagctg 20
<210> 80
<211> 25
<212> DNA
<213> Homo sapiens
<400> 80
agcagcaaga gcaggagctg tgctg 25
<210> 81
<211> 17
<212> DNA
<213> Homo sapiens
<400> 81
cacgctcagc ccgccca 17
<210> 82
<211> 16
<212> DNA
<213> Homo sapiens
<400> 82
tcctgctgct ggccgg 16
<210> 83
<211> 21
<212> DNA
<213> Homo sapiens
<400> 83
atcgagggca ggcgctccac g 21
<210> 84
<211> 21
<212> DNA
<213> Homo sapiens
<400> 84
ggagagcttc tgcacagtgg c 21
<210> 85
<211> 17
<212> DNA
<213> Homo sapiens
<400> 85
tctctcctcc agcggcc 17
<210> 86
<211> 28
<212> DNA
<213> Homo sapiens
<400> 86
cgccggcctc gtgagtctag atctacct 28
<210> 87
<211> 20
<212> DNA
<213> Homo sapiens
<400> 87
aactcccata gtgggtcgag 20
<210> 88
<211> 18
<212> DNA
<213> Homo sapiens
<400> 88
agcagctggt ggaggcgc 18
<210> 89
<211> 29
<212> DNA
<213> Homo sapiens
<400> 89
tcctgctggc cgtctctgag gagtacctc 29
<210> 90
<211> 19
<212> DNA
<213> Homo sapiens
<400> 90
ccgaaggtca ggcggaggt 19
<210> 91
<211> 20
<212> DNA
<213> Homo sapiens
<400> 91
ggatggacag gcctttcatg 20
<210> 92
<211> 21
<212> DNA
<213> Homo sapiens
<400> 92
cattggaggc attcggctgc g 21
<210> 93
<211> 21
<212> DNA
<213> Homo sapiens
<400> 93
cacgagactc cagtgctgat g 21
<210> 94
<211> 1377
<212> DNA
<213> Homo sapiens
<400> 94
gaggggaggg ggttggccgg gactcgtttg cgatgttccg ttatctggat gcggcggagg 60
gatctggcgg agggaggtgt ttatgaggcg ctgggggcgg aggaggcgaa ttagtccgag 120
tggagagagc gagctgagtg gttgtgtggt cgcgtctcgg aaaccggtag cgcttgcagc 180
atggttagct ttgtacatag catctcactt tgcacaacaa ccctgcaagg ctgaccaact 240
gactgaagag cagattgcag aattcaaaga agctttttca ctatttgaca aagatggtga 300
tggaactata acaacaaagg aattgggaac tgtaatgaga tctcttgggc agaatcccac 360
agaagcagag ttacaggaca tgattaatga agtagatgct gatggtaatg gcacaattga 420
cttccctgaa tttctgacaa tgatggcaag aaaaatgaaa gacacagaca gtgaagaaga 480
aattagagaa gcattccgtg tgtttgataa ggatggcaat ggctatatta gtgctgcaga 540
acttcgccat gtgatgacaa accttggaga gaagttaaca gatgaagaag ttgatgaaat 600
gatcagggaa gcagatattg atggtgatgg tcaagtaaac tatgaagagt ttgtacaaat 660
gatgacagca aagtgaagac cttgtacaga atgtgttaaa tttcttgtac aaaattgttt 720
atttgccttt tctttgtttg taacttatct gtaaaaggtt tctccctact gtcaaaaaaa 780
tatgcatgta tagtaattag gacttcattc ctccatgttt tcttccctta tcttactgtc 840
attgtcctaa aaccttattt tagaaaattg atcaagtaac atgttgcatg tggcttactc 900
tggatatatc taagcccttc tgcacatcta aacttagatg gagttggtca aatgagggaa 960
catctgggtt atgccttttt taaagtagtt ttctttagga actgtcagca tgttgttgtt 1020
gaagtgtgga gttgtaactc tgcgtggact atggacagtc aacaatatgt acttaaaagt 1080
tgcactattg caaaacgggt gtattatcca ggtactcgta cactattttt ttgtactgct 1140
ggtcctgtac cagaaacatt ttcttttatt gttacttgct ttttaaactt tgtttagcca 1200
cttaaaatct gcttatggca caatttgcct caaaatccat tccaagttgt atatttgttt 1260
tccaataaaa aaattacaat ttacccaatg gttgctctgc atctgagtca tttaactgtt 1320
gaagtctaat aattttgaaa ataaaatatg gcattggttt ctgcttggta aaaaaaa 1377
<210> 95
<211> 1236
<212> DNA
<213> Homo sapiens
<400> 95
agttgccagg acagcgcggc ccgagcagca acggcagaag ccgcaccgcg tcccggcggc 60
ggctgcgagt cccagtgacg cattgcaggc tgaccaactg actgaagagc agattgcaga 120
attcaaagaa gctttttcac tatttgacaa agatggtgat ggaactataa caacaaagga 180
attgggaact gtaatgagat ctcttgggca gaatcccaca gaagcagagt tacaggacat 240
gattaatgaa gtagatgctg atggtaatgg cacaattgac ttccctgaat ttctgacaat 300
gatggcaaga aaaatgaaag acacagacag tgaagaagaa attagagaag cattccgtgt 360
gtttgataag gatggcaatg gctatattag tgctgcagaa cttcgccatg tgatgacaaa 420
ccttggagag aagttaacag atgaagaagt tgatgaaatg atcagggaag cagatattga 480
tggtgatggt caagtaaact atgaagagtt tgtacaaatg atgacagcaa agtgaagacc 540
ttgtacagaa tgtgttaaat ttcttgtaca aaattgttta tttgcctttt ctttgtttgt 600
aacttatctg taaaaggttt ctccctactg tcaaaaaaat atgcatgtat agtaattagg 660
acttcattcc tccatgtttt cttcccttat cttactgtca ttgtcctaaa accttatttt 720
agaaaattga tcaagtaaca tgttgcatgt ggcttactct ggatatatct aagcccttct 780
gcacatctaa acttagatgg agttggtcaa atgagggaac atctgggtta tgcctttttt 840
aaagtagttt tctttaggaa ctgtcagcat gttgttgttg aagtgtggag ttgtaactct 900
gcgtggacta tggacagtca acaatatgta cttaaaagtt gcactattgc aaaacgggtg 960
tattatccag gtactcgtac actatttttt tgtactgctg gtcctgtacc agaaacattt 1020
tcttttattg ttacttgctt tttaaacttt gtttagccac ttaaaatctg cttatggcac 1080
aatttgcctc aaaatccatt ccaagttgta tatttgtttt ccaataaaaa aattacaatt 1140
tacccaatgg ttgctctgca tctgagtcat ttaactgttg aagtctaata attttgaaaa 1200
taaaatatgg cattggtttc tgcttggtaa aaaaaa 1236
<210> 96
<211> 4591
<212> DNA
<213> Homo sapiens
<400> 96
agattgctca tgtaactctt gagtttacat gtaatcaaca tatgctcatt gaaaacggga 60
ttgcttcaag aggactttga gtgcagggtg attaggtaag taaaagatgt aaaaaggtag 120
aaaatttttg tcacttgagt ctaaataatt gttcttataa gtgccaacgc ctgtttctgt 180
taggctcaga agatcaaagg atttggctct tttaaaatat agaaagctct agcttcagct 240
agaatttagg cctttagtaa tagccctaat ttttatgaag ccattttgtt ccagtgatct 300
tttggtgaga gatgctatgt aagtactatt cttcagaatt aggtgtcttt ttaccctaat 360
gaaataattt agattgcttt tgatacaggt aaaacaaata tcctggcttc cataattgta 420
gaaaaaactt catataggaa tccttgttgt atcaaagtag cacctgatgg gaatgaacag 480
acaggaatgg atgaaggata gcagtttgcg ttccatttca agcctatggg ctcacacatt 540
tattcagata agaacaccac ctttcactag ataaactcca acagtattca tgcatacttt 600
tgaatggcat gtaggaaatg tttgataggt acataatgta ttcacttcag gtcactaatg 660
taatacgggg tcgtgctcct tagtgttgac agatcaccta tggttctcca aaatgaacat 720
tctagtacag gaggtctagg gaggaacctg agagtatact aatgcctagg aactttctct 780
ggagtggcaa gagcagtggg aagaattatg tcaatagcta cagaaataag ggagtaagaa 840
caagtcatct ctctagtgaa ttcttcttca ctttactgag ataaacatac atgttaatga 900
gcttgagttt tcccaaaagt ataattcttc tggttcttct aagaaaatgg cactccctgg 960
aaacaaggaa gaaccaaatt tattcgcctt tgtagcagtt gggaaagtta gtgctaggaa 1020
gtcttcttga tttatagtag gctttaatct ggatattgct ggtaaaagtt tattctaaaa 1080
cctgaactct ggataagtaa tacaaaaagc ttctcaacct tccaagcaaa attgagagct 1140
ttcaggttat gtgagtaatt tggtctcttg ggtgcttaat tcattccttg aagctcattt 1200
ttgtgatctc ttccaagatt gcatttgctt ggaggtaggg agttagacaa gatggtatga 1260
ggtccctaaa ttttgacttt ccaagcaaaa ttggacagtg gttcctaaat tgctaacatc 1320
ctcgtttctt cctaaggctt ctcatgtttc atatatagta gccttcccaa agtcccattt 1380
cccacccccc cccccccccc aacccatgta gagagaacga acctgtctcc cttcctgtac 1440
agagtacggg atccttcaac tttcacacag gctgcagtgt ctgccacaca tttagctcaa 1500
ctttttttta gccttaaagt gatgtccgct gcatctgtcg ctgggttgca ccttgtggat 1560
ttagtttgca taaattttct cagcttaaac aaagttaaca ttgaatagag taagcttacc 1620
ataaagggct taataaatgc catgcatgtc tacattcggt gtggaaattg agctagtcag 1680
gttgatattt aacattgtag gttctttgtt aatttatatg aaataatggt tatcatttaa 1740
ctctttaggt tagctttgta catagcatct cactttgcac aacaaccctg caaggtaagt 1800
attgttattc ttgtgctaca aatgaagttg actgagagga ggagtaccac gtccaaggtc 1860
acacagctat taaatggcag ggctgggata ctggcctgtg actcagaact tgatgctttc 1920
cccccacgcc acgcatgcca ggttgccctt cctttcagaa atggtggaag tcctgcaaaa 1980
tgcaataaac tgaagtaatg tagcttctat taatacaaag taaataactc agatttactg 2040
gattttaaac cttattcctt gggtaaacaa tctgtgactg acttcacacc aaatatttgt 2100
tggcggagga tttggacttt agggataaaa gtggatacat tttttatttt acaaactctg 2160
tatttgaact taattattgg ctcttcaatt ttacgttacc agcttttttt tttttttttt 2220
tttttaatga atttgattta catcatggtc aaacaaaaat tgttgagcag ggaaaataaa 2280
ctgctttctg gattccttct tgaattttct catgtgccct agagaaaatg tgttccacat 2340
taaggtgtta ctttttccag gggtgtgttc atttaaaaag aatgaagcca ggcaatgttt 2400
atttttcttt tacctataaa taaatgaatg gattaatcat tgtatacttg actcccatgt 2460
tggtagggat tttagatagg aggctatttc ttgtctgtgc ttctcaatac cccataagca 2520
gttgcttcat ggatgtatat actaataagc agtgaaagaa agtgcatgtt caaagaatac 2580
aacaaggagt ctggatattt tgcaatcatc tttatatatt acggtgctct gaattaaaag 2640
ctaaaagtta ctgggtatgt ctgacacctt agtgctttat ctttgttcta ctaattttct 2700
gtgccccaat cccacttaac cctagcctca ttccttatct gtaagatagg ggataatacc 2760
actgtaaggt tattattaag attgaataag gataaaattt ataatgggtt ttagcaaatg 2820
gcagaaaata ttttctgaag aaaaccaagt gctattaaaa aaacatcaca agccttgggc 2880
ttactttggg attttaaaaa ccaagagaaa atggatggct gaactttcaa acatttggta 2940
aatattatag tactgtagtt cagagctctg gattctttgc attttgcctg ctgggtgaga 3000
aggaataaaa gtttgtgcct tttttttttt ttaatcactt taatttcaaa acaatgtgtt 3060
taaccatttg tgggagtaat tttcattttg tgagcctgaa gcattttgat tcagtgggaa 3120
tttctggtga tttatatctg gaatagaagt gagcttaagt ttagctattc taacgttgaa 3180
aaaggaagca atgtttctat tggattctaa agtatatttt caaaaatatt ctgaagtatt 3240
tgtatatctt aaacttggag ttaagacagc ttagctttga agataagaga aactagatgt 3300
gtgcattttc tatccagatg tgtttgttgc tggaactaaa tgaaacagta catggtaacc 3360
cttgaaaggt tttaaacttg tttctgtaac tgctaatcta catactctca agtcactaac 3420
cttcctcttt gatctctttg taggctgacc aactgactga agagcagatt gcagaattca 3480
aagaagcttt ttcactattt gacaaagatg gtgatggaac tataacaaca aaggaattgg 3540
gaactgtaat gagatctctt gggcagaatc ccacagaagc agagttacag gacatgatta 3600
atgaagtaga tgctgatggt aatggcacaa ttgacttccc tgaatttctg acaatgatgg 3660
caagaaaaat gaaagacaca gacagtgaag aagaaattag agaagcattc cgtgtgtttg 3720
ataaggatgg caatggctat attagtgctg cagaacttcg ccatgtgatg acaaaccttg 3780
gagagaagtt aacagatgaa gaagttgatg aaatgatcag ggaagcagat attgatggtg 3840
atggtcaagt aaactatgaa gagtttgtac aaatgatgac agcaaagtga agaccttgta 3900
cagaatgtgt taaatttctt gtacaaaatt gtttatttgc cttttctttg tttgtaactt 3960
atctgtaaaa ggtttctccc tactgtcaaa aaaatatgca tgtatagtaa ttaggacttc 4020
attcctccat gttttcttcc cttatcttac tgtcattgtc ctaaaacctt attttagaaa 4080
attgatcaag taacatgttg catgtggctt actctggata tatctaagcc cttctgcaca 4140
tctaaactta gatggagttg gtcaaatgag ggaacatctg ggttatgcct tttttaaagt 4200
agttttcttt aggaactgtc agcatgttgt tgttgaagtg tggagttgta actctgcgtg 4260
gactatggac agtcaacaat atgtacttaa aagttgcact attgcaaaac gggtgtatta 4320
tccaggtact cgtacactat ttttttgtac tgctggtcct gtaccagaaa cattttcttt 4380
tattgttact tgctttttaa actttgttta gccacttaaa atctgcttat ggcacaattt 4440
gcctcaaaat ccattccaag ttgtatattt gttttccaat aaaaaaatta caatttaccc 4500
aatggttgct ctgcatctga gtcatttaac tgttgaagtc taataatttt gaaaataaaa 4560
tatggcattg gtttctgctt ggtaaaaaaa a 4591
<210> 97
<211> 1210
<212> DNA
<213> Homo sapiens
<400> 97
agtccgagtg gagagagcga gctgagtggt tgtgtggtcg cgtctcggaa accggtagcg 60
cttgcagcat ggctgaccaa ctgactgaag agcagattgc agaattcaaa gaagcttttt 120
cactatttga caaagatggt gatggaacta taacaacaaa ggaattggga actgtaatga 180
gatctcttgg gcagaatccc acagaagcag agttacagga catgattaat gaagtagatg 240
ctgatggtaa tggcacaatt gacttccctg aatttctgac aatgatggca agaaaaatga 300
aagacacaga cagtgaagaa gaaattagag aagcattccg tgtgtttgat aaggatggca 360
atggctatat tagtgctgca gaacttcgcc atgtgatgac aaaccttgga gagaagttaa 420
cagatgaaga agttgatgaa atgatcaggg aagcagatat tgatggtgat ggtcaagtaa 480
actatgaaga gtttgtacaa atgatgacag caaagtgaag accttgtaca gaatgtgtta 540
aatttcttgt acaaaattgt ttatttgcct tttctttgtt tgtaacttat ctgtaaaagg 600
tttctcccta ctgtcaaaaa aatatgcatg tatagtaatt aggacttcat tcctccatgt 660
tttcttccct tatcttactg tcattgtcct aaaaccttat tttagaaaat tgatcaagta 720
acatgttgca tgtggcttac tctggatata tctaagccct tctgcacatc taaacttaga 780
tggagttggt caaatgaggg aacatctggg ttatgccttt tttaaagtag ttttctttag 840
gaactgtcag catgttgttg ttgaagtgtg gagttgtaac tctgcgtgga ctatggacag 900
tcaacaatat gtacttaaaa gttgcactat tgcaaaacgg gtgtattatc caggtactcg 960
tacactattt ttttgtactg ctggtcctgt accagaaaca ttttctttta ttgttacttg 1020
ctttttaaac tttgtttagc cacttaaaat ctgcttatgg cacaatttgc ctcaaaatcc 1080
attccaagtt gtatatttgt tttccaataa aaaaattaca atttacccaa tggttgctct 1140
gcatctgagt catttaactg ttgaagtcta ataattttga aaataaaata tggcattggt 1200
ttctgcttgg 1210
<210> 98
<211> 16855
<212> DNA
<213> Homo sapiens
<400> 98
agttgccagg acagcgcggc ccgagcagca acggcagaag ccgcaccgcg tcccggcggc 60
ggctgcgagt cccagtgacg cattgcaggt acaaaccagc caatcagagg caggctcaac 120
gaccaacggg ggacgcatcg ccgccacgat gctcctccgc gccgcaaagt agcgcccctc 180
aggggccgct ccaccggcct tttaacggct cgctggaaat gaaacccact tacgtcatcc 240
gttcgcccac tttccttgat ctcttgcctc atcgaccaaa taactgtgaa gaaaggggtc 300
ccgagaagag tttgagggga gggggttggc cgggactcgt ttgcgatgtt ccgttatctg 360
gatgcggcgg agggatctgg cggagggagg tgtttatgag gcgctggggg cggaggaggc 420
gaattagtcc gagtggagag agcgagctga gtggttgtgt ggtcgcgtct cggaaaccgg 480
tagcgcttgc agcatggtga gtgcatcgct gagctgccgg cgctgggcct gtggggggaa 540
gagactggag cgaactgact aaacaaagga aactcgcctc ccttacacct tcaaggagtg 600
gtttctgcca gagggatggc gcgaaagagg ccagggatgc cggcgacggt tgtgtcgcag 660
gtgctccccc acccccattc tcttcagggg ggcttcctct agtgagttga gggccggacg 720
cacagttccc gaggtggtga agctcctcgg gggcttggct ggaggaggat gggtccggga 780
tgagggacag cccagtgcac gggaaggaga gaaagtgaag gaagggagag agggagcgta 840
gagagccttc tgtcgggcgt ctggaaaggt caagcagggg gcgaattcaa tccacccgac 900
cgacggttag tgcgggcgcc aggaagcgcc tttgtccgct tgcggccgcc atgcgcccag 960
ggggcgggag gagcgcgcgg ggccctgggg cgagcgtcgg cgtcgcagtt agcccgcgtc 1020
ctccgcgtgc cgggatccag ggggcgcgcg ggcgggcggg cggcgcgctg tgtgggccga 1080
gcccgcgcgg cgcagggagc ggccggtggg ggcggggcgg gcgagcgcct cgcgggaccc 1140
ggagccgccg ccccgctcgg ccccgctcga gctccagctg ctctgctggc acctgcagga 1200
ctgcggagat ctccttggcg ctgcggggcc attggcgggg atgggcgggg gaggggggcc 1260
tcgacggttt cccatccccc tctggcaacc ctaatcttcc ttctccatct gggccctggg 1320
gcgtcttcca ccacccaggc cggatgcttt aaaaaaaatt gctttttaaa gtgtctgtcg 1380
ttgaaagaaa ttagtcttac ccttgaagtc aggggcgcgt cctcgcaata cacatcttgt 1440
tagggaaagt gttcggctcc agctagggtt ctacaaggcg tttcttgttc accgccggag 1500
ggaagcaggc tccggagtga ctgccttctg aaagtcggtc ttgtaacaat tggatggatg 1560
cctttgaaga gcccctgtcc ctattctatg cttgaaaaca gcgtgcagtc ctaatgttca 1620
agaaccacga ccacataaaa acattgctcc ccttctgctg ctttgaaaac gacccctaaa 1680
ttccgtgtag aagttgccag gtcgtcttga cgtacacttc gtttgtatga tgtttgtctg 1740
tcaaatactg tgatggaaga gtgtatgcgg gggaggagca gggaattttt aaaagcattt 1800
tccggtcacc tcagactggg agatcatgtt ctttcctgaa aaaaaaaaaa aaaaacacct 1860
aatgagggcg gtgatctgtg atacttactt tgtggttcct cctgccaagt ggttacagcg 1920
atgggtgtgt ccaggaggca aggtgacatc ttaaacagga gttagggatc cttgccaact 1980
gaaacctcca gcctgtatgg gtgtggggag acgatttcac cttaaataaa actagcgttc 2040
attgacgttt gatggatttg cttcatcttg atgcttcaaa tgttattctg aatttgaatg 2100
tgctggttac atttgctttc ttaaagatgt agttacaggc atatgtaata aacattacaa 2160
gttgtggagt aagctttttt ttttaaataa acgaagggta aagttttctt taatcagttt 2220
tgataattga atcagtaatt cgaatagatt ttttcttggt agagttggta tctacgcatt 2280
tgtggtccct tgcccagtgt taagcttttg tagttactgt ttgcatcact ggtgctttgg 2340
gggttttctg ttaaattgac agctcttact ataagagaca aagtcgaaaa aaaaaatctt 2400
aataaaaatt gacagatatc attatttgtg acagatacag taaatttgaa aattgccttc 2460
acataacttt ataattagag gactgagatt ttacattagg aatccaatta aaaaaaatta 2520
gccggacata atggcctgtg cgtgtagtcc tggctagtca atgggctgag gcaggaggat 2580
catcttgggc ccgggagttg gagactgtag tgagctatga tcacaccact gcactccctg 2640
ggcaacagag tgagaccctg tctctcaaaa aataaaaaaa attaggaccc caagttaaag 2700
tataaaaaat tttatacgga agtaaagtaa gattgctcat gtaactcttg agtttacatg 2760
taatcaacat atgctcattg aaaacgggat tgcttcaaga ggactttgag tgcagggtga 2820
ttaggtaagt aaaagatgta aaaaggtaga aaatttttgt cacttgagtc taaataattg 2880
ttcttataag tgccaacgcc tgtttctgtt aggctcagaa gatcaaagga tttggctctt 2940
ttaaaatata gaaagctcta gcttcagcta gaatttaggc ctttagtaat agccctaatt 3000
tttatgaagc cattttgttc cagtgatctt ttggtgagag atgctatgta agtactattc 3060
ttcagaatta ggtgtctttt taccctaatg aaataattta gattgctttt gatacaggta 3120
aaacaaatat cctggcttcc ataattgtag aaaaaacttc atataggaat ccttgttgta 3180
tcaaagtagc acctgatggg aatgaacaga caggaatgga tgaaggatag cagtttgcgt 3240
tccatttcaa gcctatgggc tcacacattt attcagataa gaacaccacc tttcactaga 3300
taaactccaa cagtattcat gcatactttt gaatggcatg taggaaatgt ttgataggta 3360
cataatgtat tcacttcagg tcactaatgt aatacggggt cgtgctcctt agtgttgaca 3420
gatcacctat ggttctccaa aatgaacatt ctagtacagg aggtctaggg aggaacctga 3480
gagtatacta atgcctagga actttctctg gagtggcaag agcagtggga agaattatgt 3540
caatagctac agaaataagg gagtaagaac aagtcatctc tctagtgaat tcttcttcac 3600
tttactgaga taaacataca tgttaatgag cttgagtttt cccaaaagta taattcttct 3660
ggttcttcta agaaaatggc actccctgga aacaaggaag aaccaaattt attcgccttt 3720
gtagcagttg ggaaagttag tgctaggaag tcttcttgat ttatagtagg ctttaatctg 3780
gatattgctg gtaaaagttt attctaaaac ctgaactctg gataagtaat acaaaaagct 3840
tctcaacctt ccaagcaaaa ttgagagctt tcaggttatg tgagtaattt ggtctcttgg 3900
gtgcttaatt cattccttga agctcatttt tgtgatctct tccaagattg catttgcttg 3960
gaggtaggga gttagacaag atggtatgag gtccctaaat tttgactttc caagcaaaat 4020
tggacagtgg ttcctaaatt gctaacatcc tcgtttcttc ctaaggcttc tcatgtttca 4080
tatatagtag ccttcccaaa gtcccatttc ccaccccccc ccccccccca acccatgtag 4140
agagaacgaa cctgtctccc ttcctgtaca gagtacggga tccttcaact ttcacacagg 4200
ctgcagtgtc tgccacacat ttagctcaac ttttttttag ccttaaagtg atgtccgctg 4260
catctgtcgc tgggttgcac cttgtggatt tagtttgcat aaattttctc agcttaaaca 4320
aagttaacat tgaatagagt aagcttacca taaagggctt aataaatgcc atgcatgtct 4380
acattcggtg tggaaattga gctagtcagg ttgatattta acattgtagg ttctttgtta 4440
atttatatga aataatggtt atcatttaac tctttaggtt agctttgtac atagcatctc 4500
actttgcaca acaaccctgc aaggtaagta ttgttattct tgtgctacaa atgaagttga 4560
ctgagaggag gagtaccacg tccaaggtca cacagctatt aaatggcagg gctgggatac 4620
tggcctgtga ctcagaactt gatgctttcc ccccacgcca cgcatgccag gttgcccttc 4680
ctttcagaaa tggtggaagt cctgcaaaat gcaataaact gaagtaatgt agcttctatt 4740
aatacaaagt aaataactca gatttactgg attttaaacc ttattccttg ggtaaacaat 4800
ctgtgactga cttcacacca aatatttgtt ggcggaggat ttggacttta gggataaaag 4860
tggatacatt ttttatttta caaactctgt atttgaactt aattattggc tcttcaattt 4920
tacgttacca gctttttttt tttttttttt ttttaatgaa tttgatttac atcatggtca 4980
aacaaaaatt gttgagcagg gaaaataaac tgctttctgg attccttctt gaattttctc 5040
atgtgcccta gagaaaatgt gttccacatt aaggtgttac tttttccagg ggtgtgttca 5100
tttaaaaaga atgaagccag gcaatgttta tttttctttt acctataaat aaatgaatgg 5160
attaatcatt gtatacttga ctcccatgtt ggtagggatt ttagatagga ggctatttct 5220
tgtctgtgct tctcaatacc ccataagcag ttgcttcatg gatgtatata ctaataagca 5280
gtgaaagaaa gtgcatgttc aaagaataca acaaggagtc tggatatttt gcaatcatct 5340
ttatatatta cggtgctctg aattaaaagc taaaagttac tgggtatgtc tgacacctta 5400
gtgctttatc tttgttctac taattttctg tgccccaatc ccacttaacc ctagcctcat 5460
tccttatctg taagataggg gataatacca ctgtaaggtt attattaaga ttgaataagg 5520
ataaaattta taatgggttt tagcaaatgg cagaaaatat tttctgaaga aaaccaagtg 5580
ctattaaaaa aacatcacaa gccttgggct tactttggga ttttaaaaac caagagaaaa 5640
tggatggctg aactttcaaa catttggtaa atattatagt actgtagttc agagctctgg 5700
attctttgca ttttgcctgc tgggtgagaa ggaataaaag tttgtgcctt tttttttttt 5760
taatcacttt aatttcaaaa caatgtgttt aaccatttgt gggagtaatt ttcattttgt 5820
gagcctgaag cattttgatt cagtgggaat ttctggtgat ttatatctgg aatagaagtg 5880
agcttaagtt tagctattct aacgttgaaa aaggaagcaa tgtttctatt ggattctaaa 5940
gtatattttc aaaaatattc tgaagtattt gtatatctta aacttggagt taagacagct 6000
tagctttgaa gataagagaa actagatgtg tgcattttct atccagatgt gtttgttgct 6060
ggaactaaat gaaacagtac atggtaaccc ttgaaaggtt ttaaacttgt ttctgtaact 6120
gctaatctac atactctcaa gtcactaacc ttcctctttg atctctttgt aggctgacca 6180
actgactgaa gagcagattg caggtgagaa atactcagct agattgtacc cattagattc 6240
ttattataaa ttgaatagcc aacgtcagaa taagagactt gtatgaaata attgactttg 6300
gtatatgtca tggatactaa catatgggta taatataata cagtaattca acctgctttg 6360
gcaagtggga ttgtaaactt gccgatggaa gatgtgcagg gctaattgta gttaaagaca 6420
tgtattttag tctgcgtgga tatactttgg agccttgtgg tgtagtggtg gtctttgttt 6480
tgttttctga agactacctt agtataaaac aggaattctg ggctagctaa cacgctagaa 6540
aaggaggcca agaagtaact aaggcaactt gaaatggaga atcaaaaaag gaacaattga 6600
atttacccta gttaaaatta gctaacattt taacctaaga attgcatata taatcagtca 6660
gggaataacc atttctcaag tgaaaaaatt taagaagttg gcattctatt ctataaatgt 6720
cactgtagca atgtggattt ttctcttaaa aaacagtgac agctgttgaa atgaagccgc 6780
ttaaatcttg tcccttttag tttgctatgg aagtatgcaa aattattaca taaaacctga 6840
tgtcatgttc tctttatgcc atgccataga acattaatac ttttgattta tccttgtaca 6900
ttgagatggc tggttaatgt caatgttggg gaaacttttt tttcccccct tgccggagtt 6960
gttttttttt tttattgtag tgttgaaatg ctttgcaaac tattcctttg ttttcattag 7020
acacttttat tagcatgagc accaagcagt ttatttgcca cagttttcac agtaagcagg 7080
aagggtttga taagagctca aaagcacttg agcacttttt cttaggctgg agaaaactga 7140
gaagcccagt tggaactata tagcccattt aaagcaagct ccccacttcc ataagcatat 7200
agaagtttgg gggataccag aattacacta gtcacctcaa atactatttg ataggactgt 7260
aggtagaaag ctattagtat taaagacaaa tttaagcagg ttttattttt atttattgtg 7320
taatttgact taaacttagt ttttactttc tgaggttggt aaattacatg tattgactgt 7380
tatgaacaaa aagcaaacag ttttgggaat aatttttttt ttgttgagtt acactgtttt 7440
aaaggtatca cctatttgat ctcatgtctc ctcaaaaaaa atagactggg cctgatggct 7500
ggtaatctta tcactttggg aggctgaggc agcaggatca cttgagccca ggagtttgag 7560
accagcctgg gcaacatagt gagaccccat ctctacaaag taaatgtatc gtcaaaatgt 7620
ttttctgaag tagttttttt tataaatata ctgtctcctt cccaaattgt ctcaggctgt 7680
ctaatacttt cactcttaaa ctctgacctt ctgtaataca tttcttaata ttcccagtca 7740
ggtacaggta ccaactgtat gcagtacagc atgttcactt tagggtagaa aacgttactc 7800
agtgtgccat tgcatagttg atggtctgct ctcttaaaca actctttgaa aagaaagttt 7860
gttggccggg cgcagtggct cacgcctgta attccagcac tttgggaggc cgaggcggat 7920
cacttgaggt caggagttca tgaccagcct ggccaacgtg gtgaaacccc atctctccta 7980
aaaatacaaa aattagccag gcatggtggc gtgcacctgt aatcccagcc actcaggagg 8040
ctgatgcagg agaatcactt gaacctggga ggcagaggtt gcagtgaggc aagatcatgc 8100
cactgcactc cagcctgggc aacagagcga gactttgcct caaaaaaaaa aaagtttgtg 8160
tctattgaat ataagaggat ccctcttcag tgattgatag catttttatt ttttaattta 8220
ttttgagaca gtttcactct tgttgcccag gctggagtgc agtggctcaa cttctgtctc 8280
ccgggttcaa gctgttctgc ttcagtctcc cgagtagctg ggattagagg catgcaccac 8340
ctggctattt ttgtattttt agtagagatg gggtttctcc atgttggtca ggctggtctc 8400
aaactcgcaa cctcaggtga tccacccgcc tcagcctcct aaagtgctgg gattacaggt 8460
gtgaatcacc atgcctggcc tggtagaatt cttataaaga atacttgtag ttcatcaaaa 8520
ctgtgacatt caggacctgt tctctttatt gtctttaagt taaatcctat cttttcttgg 8580
ctttcatcat aaaattaggt ttccaatggg agtagaggga aaaaaatctg ttcttaggtt 8640
ctcttcttat cctgcctttt cctagaccac agatttcttt aaagccattc cttggacctc 8700
caggtttcag ttaagattta gggcagagga accaaaactt ctatgctact aaaataaaaa 8760
tcatgtgcgg tcagggacct ttttgttcta ctttgtaggc ccggtacctg ccacatagta 8820
atcattgaat attccttgaa taaattttat tctcaatgag tgtgtaacac aaaaaagttc 8880
tagagcacta ctatcctaag atttctgcct actctccaag tcccttcctc ccaaatttgg 8940
tatatttcag tgtttacctt tgagatgaag gcaatttttt aatctggtaa attgtaattg 9000
ttggtggctg ggcatggtgg cgcatgtcta atcccaacac tttgggaggc tgaggcagtg 9060
ggattgcttg agcccaggag ttcaagacca gtctgggcaa cacagcaaga ccctgtctca 9120
aagaaaagaa aaaaaaattt tttttttttt ttttttagtt gtaagtgctg gtgaccgcta 9180
acatccttgt gtagatgaag ttactaaatt tttttttttt tttttttttt tttttttttt 9240
tttgagacgg agcttcactc tcttgcccag gctggagtgc agtagcatga tcttggctca 9300
ctgcaacctt tgctgtccaa cttcaagcaa ttctcctggc tcagtctccc aagtagctgg 9360
gattacaggc gtgcaccacc acacccggct agtttttgta tttttaggag agatggggtt 9420
tcaccatgtt ggccaggctg gtcttgaact gctgacgtca ggtgatccgc ttaccttgac 9480
ctcccaaagt gttgggatta caggcatgag ccactgctcc cggcctaaaa ttttttatat 9540
tacttggtcg tataaagcat tccagtctag tatgacatca ctaacaattt cattttgttg 9600
ataactctgc catgatgtca ttagttgttg ctgtttgact tttggaagac tgataggaaa 9660
aatgtacagt attttttcct taagaagtct gtacctaaac tttcattaaa ttttcaaggt 9720
ccaaatttgt ttgagaaaaa tattaatatt actcaatgta tagcaacaac tgcatgaagc 9780
gccaaaagag ttccagtaca tgatctttaa gggattatta agttcagaat tttgtgaaga 9840
aatagaagtt aataaacagt catttgattt gttttgtaat tgtcttgtga taacctattt 9900
taataaaatt tttaaaacat gttattttaa taaaattata tgtttaggta ataaactaat 9960
tagggaaggg ccttggggtt gctaatgaac aaataaaact tgagtaatag atttttctga 10020
aagtttcagt ttggtcagct aaaatggatt ttggtaggtt ccttatatct atcaattatg 10080
tagaagatag ctgttctgtg gcattcagga cctgttctct ttattgtgtg tttaggtttt 10140
gactcttgga tttaatttca ggtcattcct gggagttaca gtttagaatt atatgcttct 10200
atacataaag attacgctag ttctgaagta caggaaaact gtaaaggcag gtgaattaaa 10260
attttacttt ggggtttatt attttgagtt tttacaggta ttttttactc tttagtataa 10320
aaatacaagt aaaaatttgg aataaacctt gacctttaaa agaaatgtta tttgttcctt 10380
tcttgaatga ataacaaatg gtattagcat agatacggtt ttattttctg cattttactt 10440
attctagcaa acattttaag tgttattaga tttttaaatt tctcgaaagt tatacatagt 10500
cttacactat gcatcttcca gtatttagct ttttgttaaa tcatgtaata gaaaggtgat 10560
tactgctaat taaacattgg gaatttatgc acctaatggt ggtgttaaaa gatacccata 10620
gcagagaatg taatataaac aaatacctca aagtccttta attttcttgt aacctaaatt 10680
aggtgaaagg tgcaatgtgt ctgaactcca atatatgtat ttctagatat ttctacattc 10740
tgtttaaaaa cagtaaaatt gaaatgtctt tatcaattgt gctatttgta ggtggagact 10800
ccctgatcta tttttgtcat taggttgatc taggttagca ctgtatacta tcttcataaa 10860
atcaattagt gtggtatgaa ccttctgatt ggtattagat gagttcctct ataaaccagt 10920
aatatttaaa taagaaagaa tgcagttagg aggcaattgt aatagccctg gcaaaggacg 10980
atggagcctt gaaccaaaat actggttgta gagatggagg aaaaatcagg cagtatttaa 11040
atgatagaat tcgagacctg ttgacagatt tcagactgaa agagttaaaa gtggctcttg 11100
ggcttttgct agtaccttta gggttgcctg ggagtataga attcattttc atatgttttg 11160
cttgtcatca gccaggggag ctatatcctg tagacagcca gaaataaaga catttattga 11220
gcgagatggg tagactaaag atatcttcgt tgtaagtggg tatagatgaa gtggccaagg 11280
agtggaaaaa aaggataaaa ttggtcacat ctagacataa gagacaggag taagagcctt 11340
tggcagtata tggtaggagg aaaatcaaag tactgttacg aaggccaaga aaaattttga 11400
gagtttttcc atgcagtttt ggatgctgca aaaaaatgag atagtcttta tcttgacatt 11460
tattaagtat gtatttgttg gacatagttc taagtgtttg acacatacta atttttttat 11520
ggggggtgac caggtgaata ccccttgtgg gcatggtata ctgtgtcacc ccacttactg 11580
ggcacattta tgtcatttca cagaaatgag gaagctgagg cagaaaaggt ttagtagctt 11640
gtccatattg cattgccaga agaagaaaca gagctaggaa attctaaccc agtagtcaag 11700
ttacaaagtc tcattttagt ttctatgcca tatggcttca cattgaagca tgcttgatgg 11760
attgggtgac tgactagtag tcattggtaa actcagcatt ttcaggtgat gagttggagc 11820
tggatgtcat tttaaaatag tggattgttt ggagagagga aattggtatg agtagtagtg 11880
ccttccaaaa tttggggagg gataagggca agcatttaaa atataactaa ggtttcaatt 11940
tagttttagg ctaagcgatg tgaagatatt tatgtggtaa tgggcaaatt agtggaagaa 12000
tagttgagtc cagggaagag gtaatacgga atgaaactgg aaggtgtacg cgaattggag 12060
ttagggataa gcaggcaggg aataaattgg ccttggaccg taaagaaggt acaccatttc 12120
ttacacatgt gtcacataaa ttttcaaatg tatggctatg ttgggaaagc ttaatggccc 12180
aatgaacttg gaaacttttt gtattcattt gctgataggg tctaatattt tctgggaaat 12240
gacttacttg gaaaatacta gctttattat ttactgattg gtataacttt gcagtatcaa 12300
agttagtctg ttttagtttc tttctttctt tttttttttt tgagacaagt ctcactctgt 12360
tgcccaagct ggagtgcagt ggtgtgatct cggctcactg caacctccgc ctctcgggtt 12420
caagcagttc tgctgctgca gcctccccag tagctgggac tacaggcgca cgccgccaca 12480
cccagcttgt gtgtgtgttt gtgttttaat agagacgggg gactacaggc ccacgctgcc 12540
acacccagcg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt ttagtagaga 12600
cgggggacta caggcacacg ccgccacacc cagcttgtgt gtgtgtgtgt tttagtagag 12660
acggggtttc ttttcttttt cttctttttt tttttttttg agacggagtc tcgctctgtc 12720
gcccaggctg gagtgcagtg gcgcaatatc agctcactgc aagctctgcc tcccaggttc 12780
acgccattct cctgcctcag cctcccgagt agctgggact ataggcgccc gccaccacgc 12840
ccggctaatt tttttgtatt tttagtagag atggggtttc accgtgttag ccaggatggt 12900
ctcgatctcc tgacctcatg atccacccgc ctcagcctcc caaagtgctg ggattacagg 12960
cttgagccac cgcgcccggc ctgagacggg gtttcaccct gttgttcagg ctggtctgga 13020
actcaccctg agctcaggca gtctgcccac cttggcctcc caaagtgcta ggattacagg 13080
tgtgagccac tgcacctggc ttgttttagt ttatctgtaa atggtgaatg aagccaggta 13140
gtctggagtg ttgcaccagc aggaggtttc catgtaatct agtgatgtat tagaaggaac 13200
atatagccgg gcacagtggc tcatgccctg taatcccagc actttgggag gcagagacag 13260
gcggatcacc tgaggttggg agttcgaggc cagcctgacc aacgtggaga aaccccatct 13320
ctactaaaaa tagaaaatta gctgggcgtg gtggtgcatg cctgtaattc cagctactcg 13380
ggaggctgag gcaggagaat tgcttgatcc tgggaggagg aggttgcggt gggctgagat 13440
tgcaccattg cactccagcc tggacaacaa gagcgaaagt ccatctcaaa aaaaaaaaca 13500
acagcaggaa ggaacatact atcacaacaa gatgttgagg aataatcagt ttcactatat 13560
aaggttgggg ttttaatatt ccaaagaaag ctcaaaatga tctttgttct cagtgacatg 13620
catttagcta aaactggaca tttatatctt gatcagccca ttgttataga ctctttatat 13680
agtcccttct cctgccttac tagaaaggga aagtagcctg ttttaattta gtaggtgatt 13740
gatttagaca tagtggctaa ctctaaacac agtatacaga aacagtttaa ttactctgta 13800
gaaatacgta tttgggtacc agtagtctta tttttgtttt gtgagtgtag gttaggtctg 13860
taattttgaa ttatgttcca cagagcagct tcagtgacag aggagccagt catttgggga 13920
tttggttctt ttcctctgta aacctaggat aattttactt aggtcagcat gaaagtacag 13980
tggtatgatt ggtcaaagat atatttgaaa tattatcata aggtatcata aagattggtt 14040
aatctttagg agtcaaagtc acatttcaat tgctacctcc attggtattt ttccgttaaa 14100
agtttttggg tttttctgag acgtggggtc ttacagtttg gccaggctga agtgcagtgg 14160
ctgttcactg gcacgatccc accactgagt aggctttaag agttaatacg tttcatttag 14220
gttacatttt attattaatc tgtgtatttg gattgtggtc tttctttcaa acagaattca 14280
aagaagcttt ttcactattt gacaaagatg gtgatggaac tataacaaca aaggaattgg 14340
gaactgtaat gagatctctt gggcagaatc ccacagaagc agagttacag gacatgatta 14400
atgaagtaga tgctgatggt aagtcttcaa ttttgtgggg ctgggagggg ttgaagaagt 14460
gatacttaga tgtttccact aaacctttgc tgtttgctta tatgtttcca ctaaagcttt 14520
gatgtttcca ctaaaccatt tcaggtaatg gcacaattga cttccctgaa tttctgacaa 14580
tgatggcaag aaaaatgaaa gacacagaca gtgaagaaga aattagagaa gcattccgtg 14640
tgtttgataa ggtacgtcaa ggactggata tgttaaattt tgaggatgaa atgaagatac 14700
caggactcat tatgaagact tgtgtttttt tggttgtttt tttttttttt tttttttttt 14760
tttttgatga tttaccaaca tattttaatt accaagcaaa agctttttaa gaattcagta 14820
tagactttct aatatatgta ttgcgttcat cttgtcaaag gaggtgtcac ttgactttgg 14880
gactaggaaa taatgatttc aatgtaggac attttgcttg gctcttaatg acatttgtag 14940
gtcaactgtg tagatttgta tgcatttcta aagtatgttt ttcccccaat gtgaaattta 15000
gtagtaaact taataaattt ccattccaac tctcaagtct gtaatttgac tcagaaacta 15060
tactaaattt tttgctagga tggcaatggc tatattagtg ctgcagaact tcgccatgtg 15120
atgacaaacc ttggagagaa gttaacagat gaagaagttg atgaaatgat cagggaagca 15180
gatattgatg gtgatggtca agtaaactat gaaggtaaat gtttcagtct cacgcctcat 15240
tcttcacttt gatttttaag ataagaggct ctttgttagg gaactgatcg aaattagtga 15300
cccttcccct gaaattaggt tgctaaaaca gttacttaca tttaaccttc ttaaaattca 15360
gagtgttgtc tgcagactag gtaacattgc tctgacttga gaacttaatt tagaaatatt 15420
tactatcagg ttctatccct acacctggaa tcagcatttt aataggattc ttgggtgatt 15480
catgtataaa gtttgagaag cactgttcag tgtttgtgtg attgtggaac aatgtggaaa 15540
gcaaacttat tccaagtttc ctaaaatgaa attaatgtga ctttctttcc ccgcactgta 15600
ttgtcttttt tctttaattg gctttagtct gaaactgaag tttacatgtg cttcaaaagt 15660
atcgtatcta ctaactttta agatggccat atcaggaagc aaggcatatg aaactgaagg 15720
attttgagta aaactctgta tttttttcat gatgtaacta cttaacttag aaaagagcat 15780
aaaatgtaat gttataaaaa ttaaacctag cccatagcat tgaatttaca atattgtctt 15840
gtaatccagc agacttaaaa ttcaagtcta aactaagagc caagaatgct cttttttata 15900
ttggcctatc taaagcgtta atttggctct tactaataaa cctgaatagt tatggttaat 15960
gaagttccag cctgggcaat aaactagctt ccctctgtac ttaatggtaa ttctgaggaa 16020
agagaggaat ggaaagagta ctcagtaatt gagtaaatgt gatttttttt tttttttttt 16080
ttttttggtc ttttgctatt gactcatttt ttgtgtactt cttctttttc agagtttgta 16140
caaatgatga cagcaaagtg aagaccttgt acagaatgtg ttaaatttct tgtacaaaat 16200
tgtttatttg ccttttcttt gtttgtaact tatctgtaaa aggtttctcc ctactgtcaa 16260
aaaaatatgc atgtatagta attaggactt cattcctcca tgttttcttc ccttatctta 16320
ctgtcattgt cctaaaacct tattttagaa aattgatcaa gtaacatgtt gcatgtggct 16380
tactctggat atatctaagc ccttctgcac atctaaactt agatggagtt ggtcaaatga 16440
gggaacatct gggttatgcc ttttttaaag tagttttctt taggaactgt cagcatgttg 16500
ttgttgaagt gtggagttgt aactctgcgt ggactatgga cagtcaacaa tatgtactta 16560
aaagttgcac tattgcaaaa cgggtgtatt atccaggtac tcgtacacta tttttttgta 16620
ctgctggtcc tgtaccagaa acattttctt ttattgttac ttgcttttta aactttgttt 16680
agccacttaa aatctgctta tggcacaatt tgcctcaaaa tccattccaa gttgtatatt 16740
tgttttccaa taaaaaaatt acaatttacc caatggttgc tctgcatctg agtcatttaa 16800
ctgttgaagt ctaataattt tgaaaataaa atatggcatt ggtttctgct tggta 16855
<210> 99
<211> 1675
<212> DNA
<213> Homo sapiens
<400> 99
attcctgaag ctgacagcat tcgggccgag atgtctcgct ccgtggcctt agctgtgctc 60
gcgctactct ctctttctgg cctggaggct atccagcgta ctccaaagat tcaggtttac 120
tcacgtcatc cagcagagaa tggaaagtca aatttcctga attgctatgt gtctgggttt 180
catccatccg acattgaagt tgacttactg aagaatggag agagaattga aaaagtggag 240
cattcagact tgtctttcag caaggactgg tctttctatc tcttgtacta cactgaattc 300
acccccactg aaaaagatga gtatgcctgc cgtgtgaacc atgtgacttt gtcacagccc 360
aagatagtta agtgggatcg agacatgtaa gcagcatcat ggaggtttga agatgccgca 420
tttggattgg atgaattcca aattctgctt gcttgctttt taatattgat atgcttatac 480
acttacactt tatgcacaaa atgtagggtt ataataatgt taacatggac atgatcttct 540
ttataattct actttgagtg ctgtctccat gtttgatgta tctgagcagg ttgctccaca 600
ggtagctcta ggagggctgg caacttagag gtggggagca gagaattctc ttatccaaca 660
tcaacatctt ggtcagattt gaactcttca atctcttgca ctcaaagctt gttaagatag 720
ttaagcgtgc ataagttaac ttccaattta catactctgc ttagaatttg ggggaaaatt 780
tagaaatata attgacagga ttattggaaa tttgttataa tgaatgaaac attttgtcat 840
ataagattca tatttacttc ttatacattt gataaagtaa ggcatggttg tggttaatct 900
ggtttatttt tgttccacaa gttaaataaa tcataaaact tgatgtgtta tctcttatat 960
ctcactccca ctattacccc tttattttca aacagggaaa cagtcttcaa gttccacttg 1020
gtaaaaaatg tgaacccctt gtatatagag tttggctcac agtgtaaagg gcctcagtga 1080
ttcacatttt ccagattagg aatctgatgc tcaaagaagt taaatggcat agttggggtg 1140
acacagctgt ctagtgggag gccagccttc tatattttag ccagcgttct ttcctgcggg 1200
ccaggtcatg aggagtatgc agactctaag agggagcaaa agtatctgaa ggatttaata 1260
ttttagcaag gaatagatat acaatcatcc cttggtctcc ctgggggatt ggtttcagga 1320
ccccttcttg gacaccaaat ctatggatat ttaagtccct tctataaaat ggtatagtat 1380
ttgcatataa cctatccaca tcctcctgta tactttaaat catttctaga ttacttgtaa 1440
tacctaatac aatgtaaatg ctatgcaaat agttgttatt gtttaaggaa taatgacaag 1500
aaaaaaaagt ctgtacatgc tcagtaaaga cacaaccatc cctttttttc cccagtgttt 1560
ttgatccatg gtttgctgaa tccacagatg tggagcccct ggatacggaa ggcccgctgt 1620
actttgaatg acaaataaca gatttaaaat tttcaaggca tagttttata cctga 1675
<210> 100
<211> 6673
<212> DNA
<213> Homo sapiens
<400> 100
aatataagtg gaggcgtcgc gctggcgggc attcctgaag ctgacagcat tcgggccgag 60
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct 120
atccagcgtg agtctctcct accctcccgc tctggtcctt cctctcccgc tctgcaccct 180
ctgtggccct cgctgtgctc tctcgctccg tgacttccct tctccaagtt ctccttggtg 240
gcccgccgtg gggctagtcc agggctggat ctcggggaag cggcggggtg gcctgggagt 300
ggggaagggg gtgcgcaccc gggacgcgcg ctacttgccc ctttcggcgg ggagcagggg 360
agacctttgg cctacggcga cgggagggtc gggacaaagt ttagggcgtc gataagcgtc 420
agagcgccga ggttggggga gggtttctct tccgctcttt cgcggggcct ctggctcccc 480
cagcgcagct ggagtggggg acgggtaggc tcgtcccaaa ggcgcggcgc tgaggtttgt 540
gaacgcgtgg aggggcgctt ggggtctggg ggaggcgtcg cccgggtaag cctgtctgct 600
gcggctctgc ttcccttaga ctggagagct gtggacttcg tctaggcgcc cgctaagttc 660
gcatgtccta gcacctctgg gtctatgtgg ggccacaccg tggggaggaa acagcacgcg 720
acgtttgtag aatgcttggc tgtgatacaa agcggtttcg aataattaac ttatttgttc 780
ccatcacatg tcacttttaa aaaattataa gaactacccg ttattgacat ctttctgtgt 840
gccaaggact ttatgtgctt tgcgtcattt aattttgaaa acagttatct tccgccatag 900
ataactacta tggttatctt ctgcctctca cagatgaaga aactaaggca ccgagatttt 960
aagaaactta attacacagg ggataaatgg cagcaatcga gattgaagtc aagcctaacc 1020
agggcttttg cgggagcgca tgccttttgg ctgtaattcg tgcatttttt tttaagaaaa 1080
acgcctgcct tctgcgtgag attctccaga gcaaactggg cggcatgggc cctgtggtct 1140
tttcgtacag agggcttcct ctttggctct ttgcctggtt gtttccaaga tgtactgtgc 1200
ctcttacttt cggttttgaa aacatgaggg ggttgggcgt ggtagcttac gcctgtaatc 1260
ccagcactta gggaggccga ggcgggagga tggcttgagg tccgtagttg agaccagcct 1320
ggccaacatg gtgaagcctg gtctctacaa aaaataataa caaaaattag ccgggtgtgg 1380
tggctcgtgc ctgtggtccc agctgctccg gtggctgagg cgggaggatc tcttgagctt 1440
aggcttttga gctatcatgg cgccagtgca ctccagcgtg ggcaacagag cgagaccctg 1500
tctctcaaaa aagaaaaaaa aaaaaaaaga aagagaaaag aaaagaaaga aagaagtgaa 1560
ggtttgtcag tcaggggagc tgtaaaacca ttaataaaga taatccaaga tggttaccaa 1620
gactgttgag gacgccagag atcttgagca ctttctaagt acctggcaat acactaagcg 1680
cgctcacctt ttcctctggc aaaacatgat cgaaagcaga atgttttgat catgagaaaa 1740
ttgcatttaa tttgaataca atttatttac aacataaagg ataatgtata tatcaccacc 1800
attactggta tttgctggtt atgttagatg tcattttaaa aaataacaat ctgatattta 1860
aaaaaaaatc ttattttgaa aatttccaaa gtaatacatg ccatgcatag accatttctg 1920
gaagatacca caagaaacat gtaatgatga ttgcctctga aggtctattt tcctcctctg 1980
acctgtgtgt gggttttgtt tttgttttac tgtgggcata aattaatttt tcagttaagt 2040
tttggaagct taaataactc tccaaaagtc ataaagccag taactggttg agcccaaatt 2100
caaacccagc ctgtctgata cttgtcctct tcttagaaaa gattacagtg atgctctcac 2160
aaaatcttgc cgccttccct caaacagaga gttccaggca ggatgaatct gtgctctgat 2220
ccctgaggca tttaatatgt tcttattatt agaagctcag atgcaaagag ctctcttagc 2280
ttttaatgtt atgaaaaaaa tcaggtcttc attagattcc ccaatccacc tcttgatggg 2340
gctagtagcc tttccttaat gatagggtgt ttctagagag atatatctgg tcaaggtggc 2400
ctggtactcc tccttctccc cacagcctcc cagacaagga ggagtagctg ccttttagtg 2460
atcatgtacc ctgaatataa gtgtatttaa aagaatttta tacacatata tttagtgtca 2520
atctgtatat ttagtagcac taacacttct cttcattttc aatgaaaaat atagagttta 2580
taatattttc ttcccacttc cccatggatg gtctagtcat gcctctcatt ttggaaagta 2640
ctgtttctga aacattaggc aatatattcc caacctggct agtttacagc aatcacctgt 2700
ggatgctaat taaaacgcaa atcccactgt cacatgcatt actccatttg atcataatgg 2760
aaagtatgtt ctgtcccatt tgccatagtc ctcacctatc cctgttgtat tttatcgggt 2820
ccaactcaac catttaaggt atttgccagc tcttgtatgc atttaggttt tgtttctttg 2880
ttttttagct catgaaatta ggtacaaagt cagagagggg tctggcatat aaaacctcag 2940
cagaaataaa gaggttttgt tgtttggtaa gaacatacct tgggttggtt gggcacggtg 3000
gctcgtgcct gtaatcccaa cactttggga ggccaaggca ggctgatcac ttgaagttgg 3060
gagttcaaga ccagcctggc caacatggtg aaatcccgtc tctactgaaa atacaaaaat 3120
taaccaggca tggtggtgtg tgcctgtagt cccaggaatc acttgaaccc aggaggcgga 3180
ggttgcagtg agctgagatc tcaccactgc acactgcact ccagcctggg caatggaatg 3240
agattccatc ccaaaaaata aaaaaataaa aaaataaaga acataccttg ggttgatcca 3300
cttaggaacc tcagataata acatctgcca cgtatagagc aattgctatg tcccaggcac 3360
tctactagac acttcataca gtttagaaaa tcagatgggt gtagatcaag gcaggagcag 3420
gaaccaaaaa gaaaggcata aacataagaa aaaaaatgga aggggtggaa acagagtaca 3480
ataacatgag taatttgatg ggggctatta tgaactgaga aatgaacttt gaaaagtatc 3540
ttggggccaa atcatgtaga ctcttgagtg atgtgttaag gaatgctatg agtgctgaga 3600
gggcatcaga agtccttgag agcctccaga gaaaggctct taaaaatgca gcgcaatctc 3660
cagtgacaga agatactgct agaaatctgc tagaaaaaaa acaaaaaagg catgtataga 3720
ggaattatga gggaaagata ccaagtcacg gtttattctt caaaatggag gtggcttgtt 3780
gggaaggtgg aagctcattt ggccagagtg gaaatggaat tgggagaaat cgatgaccaa 3840
atgtaaacac ttggtgcctg atatagcttg acaccaagtt agccccaagt gaaataccct 3900
ggcaatatta atgtgtcttt tcccgatatt cctcaggtac tccaaagatt caggtttact 3960
cacgtcatcc agcagagaat ggaaagtcaa atttcctgaa ttgctatgtg tctgggtttc 4020
atccatccga cattgaagtt gacttactga agaatggaga gagaattgaa aaagtggagc 4080
attcagactt gtctttcagc aaggactggt ctttctatct cttgtactac actgaattca 4140
cccccactga aaaagatgag tatgcctgcc gtgtgaacca tgtgactttg tcacagccca 4200
agatagttaa gtggggtaag tcttacattc ttttgtaagc tgctgaaagt tgtgtatgag 4260
tagtcatatc ataaagctgc tttgatataa aaaaggtcta tggccatact accctgaatg 4320
agtcccatcc catctgatat aaacaatctg catattggga ttgtcaggga atgttcttaa 4380
agatcagatt agtggcacct gctgagatac tgatgcacag catggtttct gaaccagtag 4440
tttccctgca gttgagcagg gagcagcagc agcacttgca caaatacata tacactctta 4500
acacttctta cctactggct tcctctagct tttgtggcag cttcaggtat atttagcact 4560
gaacgaacat ctcaagaagg tataggcctt tgtttgtaag tcctgctgtc ctagcatcct 4620
ataatcctgg acttctccag tactttctgg ctggattggt atctgaggct agtaggaagg 4680
gcttgttcct gctgggtagc tctaaacaat gtattcatgg gtaggaacag cagcctattc 4740
tgccagcctt atttctaacc attttagaca tttgttagta catggtattt taaaagtaaa 4800
acttaatgtc ttcctttttt ttctccactg tctttttcat agatcgagac atgtaagcag 4860
catcatggag gtaagttttt gaccttgaga aaatgttttt gtttcactgt cctgaggact 4920
atttatagac agctctaaca tgataaccct cactatgtgg agaacattga cagagtaaca 4980
ttttagcagg gaaagaagaa tcctacaggg tcatgttccc ttctcctgtg gagtggcatg 5040
aagaaggtgt atggccccag gtatggccat attactgacc ctctacagag agggcaaagg 5100
aactgccagt atggtattgc aggataaagg caggtggtta cccacattac ctgcaaggct 5160
ttgatctttc ttctgccatt tccacattgg acatctctgc tgaggagaga aaatgaacca 5220
ctcttttcct ttgtataatg ttgttttatt cttcagacag aagagaggag ttatacagct 5280
ctgcagacat cccattcctg tatggggact gtgtttgcct cttagaggtt cccaggccac 5340
tagaggagat aaagggaaac agattgttat aacttgatat aatgatacta taatagatgt 5400
aactacaagg agctccagaa gcaagagaga gggaggaact tggacttctc tgcatcttta 5460
gttggagtcc aaaggctttt caatgaaatt ctactgccca gggtacattg atgctgaaac 5520
cccattcaaa tctcctgtta tattctagaa cagggaattg atttgggaga gcatcaggaa 5580
ggtggatgat ctgcccagtc acactgttag taaattgtag agccaggacc tgaactctaa 5640
tatagtcatg tgttacttaa tgacggggac atgttctgag aaatgcttac acaaacctag 5700
gtgttgtagc ctactacacg cataggctac atggtatagc ctattgctcc tagactacaa 5760
acctgtacag cctgttactg tactgaatac tgtgggcagt tgtaacacaa tggtaagtat 5820
ttgtgtatct aaacatagaa gttgcagtaa aaatatgcta ttttaatctt atgagaccac 5880
tgtcatatat acagtccatc attgaccaaa acatcatatc agcatttttt cttctaagat 5940
tttgggagca ccaaagggat acactaacag gatatactct ttataatggg tttggagaac 6000
tgtctgcagc tacttctttt aaaaaggtga tctacacagt agaaattaga caagtttggt 6060
aatgagatct gcaatccaaa taaaataaat tcattgctaa cctttttctt ttcttttcag 6120
gtttgaagat gccgcatttg gattggatga attccaaatt ctgcttgctt gctttttaat 6180
attgatatgc ttatacactt acactttatg cacaaaatgt agggttataa taatgttaac 6240
atggacatga tcttctttat aattctactt tgagtgctgt ctccatgttt gatgtatctg 6300
agcaggttgc tccacaggta gctctaggag ggctggcaac ttagaggtgg ggagcagaga 6360
attctcttat ccaacatcaa catcttggtc agatttgaac tcttcaatct cttgcactca 6420
aagcttgtta agatagttaa gcgtgcataa gttaacttcc aatttacata ctctgcttag 6480
aatttggggg aaaatttaga aatataattg acaggattat tggaaatttg ttataatgaa 6540
tgaaacattt tgtcatataa gattcatatt tacttcttat acatttgata aagtaaggca 6600
tggttgtggt taatctggtt tatttttgtt ccacaagtta aataaatcat aaaacttgat 6660
gtgttatctc tta 6673
<210> 101
<211> 434
<212> DNA
<213> Homo sapiens
<400> 101
acttccgctc gtccgcctaa taccgcgcct gcgcaccgcg tctcttcctt tctgggctcg 60
gacctaggtc gcggcgacat ggccaaacgt accaagaaag tcgggatcgt cggtaaatac 120
gggacccgct atggggcctc cctccggaaa atggtgaaga aaattgaaat cagccagcac 180
gccaagtaca cttgctcttt ctgtggcaaa accaagatga agagacgagc tgtggggatc 240
tggcactgtg gttcctgcat gaagacagtg gctggcggtg cctggacgta caataccact 300
tccgctgtca cggtaaagtc cgccatcaga agactgaagg agttgaaaga ccagtagacg 360
ctcctctact ctttgagaca tcactggcct ataataaatg ggttaattta tgtaacaaaa 420
aaaaaaaaaa aaaa 434
<210> 102
<211> 2671
<212> DNA
<213> Homo sapiens
<400> 102
acttccgctc gtccgcctaa taccgcgcct gcgcaccgcg tctcttcctt tctgggctcg 60
gacctaggtc gcggcgacat ggtgagtgtg ggtctctgtg cggcctagaa ctctatctgc 120
ctgcatctgt ccttgttttc ttctcccgca cccatctcct ctcctgcctt accccgtgtt 180
ctctcctgtc tccatgcctt tgcaggagac accattgtcg gaagctcccc aaggcggagg 240
ggcgggggcg ccttggctgg gcctggcgcg ctccagccgg gttaacgccg ggccttcgga 300
gcgcgcggcc agccctgggc actggtttcg ttgggttgaa tttagggaaa actaggtcat 360
atgtaattca catgtcggtc acacgtcagt gaggtggagg aacggtgtgt ggaggctcca 420
gggcctgcct gggttccagg tctatcactg gtttctccct tcactctaaa caggccaaac 480
gtaccaagaa agtcgggatc gtcggtaaat acgggacccg ctatggggcc tccctccgga 540
aaatggtgaa gaaaattgaa atcagccagc acgccaagta cacttgctct ttctgtggca 600
aagtaagtaa ggcaaagtct ctggtgagag gagagggagg gcaggtttct tacccaagtg 660
aggcctgact tcaaggtatt ttataagccg tgtgctggtg ggcagttgga attactcata 720
ccgttgatta tgagttttaa gataaaagtg ttgatggtaa cttcagattt tgtgagacgt 780
ttttcattta aagaaaaccg cttaaacgtt aatgggtaaa ataatcattt gacagagtgc 840
ccccagccta agccaaacct gctttgtggg aaatgattcc atcagttttg tctactgatg 900
tttctgcacc aactcccaag atgtctgtgc atctaatacc attctacttg ttctgcgagg 960
gatttttgtt tgataaaggt ttgaacgttt atgtgcaaaa tactgcatta cagcaatccc 1020
tgttttgttt ttgagggaga aagggaggct ttcacatccc tgacaataag gtgaatccaa 1080
atttagactt ctggatgctt gtaagagaaa atacttactt ggttcatagt gaaaattggt 1140
tctcttttat agaccaagat gaagagacga gctgtgggga tctggcactg tggttcctgc 1200
atgaagacag tggctggcgg tgcctggacg tacaagtgag tctagttcct tgtggtattt 1260
ggaagtgtgt ggaccacata ggcccaaatt ccaggttgct gctggatggg ctagttttaa 1320
cactttctca ggactgagag aataaggatg cctttgtatt ttcaggattc ttccgtggtg 1380
gtttattttc agttattgaa agagtaaaca caaaactacc aaaatagaag tcggaaatct 1440
aattcacaga ctactttaga atttgatggt cactgggcac attgttgtga acattgtcat 1500
gatactgtgc aggtccatta gtggggctga atctactgaa cgttgatttg cactgcaagt 1560
tttgataaaa ataggtgaag gggtcagtta gttcaaaact gtatttggaa cttgaggcca 1620
tcaggaccac cacagtttcg tctttctgaa cagtattaga ctgctgcagg tttgtgaatc 1680
tgcaactcag tatcacctga cagggcgata ctacaaacac tatactacaa actagcatct 1740
agacctgtgt tgtccaatac actaagcaca tatatggcta gtgtaattaa agaattggat 1800
tttaaagttt cagtcaattt aaacttaaac cgaagcagtg gaaaatgttg aaatatatat 1860
atattccttg tgggggtttt tattagggca gaatggaaaa tgggaactag agtgctttct 1920
tggttctgat aggaaagtga attatttata tacttacaat acaggatggt gattttcagg 1980
tatagttcct gaattttatg gtaaaacttt tgtagtcatt tcaatagctg tctttcccaa 2040
aggcacttta gtgtccgctc ttatttcctt aatcattgtt ctcactgtat catcttgtaa 2100
tttattcatt tcttgtaatc tgtccattcc cttttaataa gtttaggtca gcctcttaga 2160
accatttctt tttcatggga tggggtaggg ggagttaaag cttgcttgtc cacaactgag 2220
ttacttataa aaaaaaaagc aactctggtt gagaaatcag atgcatgaga ttgtatgtct 2280
aattctgcaa gatcctgaag gcatggctct taaaggatgc catcatgtag tttagaagcc 2340
actaatttcc gaggagtaat ctaatgttgg ttagatcttt ggattgactg cagcaaagta 2400
ttggtagagc agtctatctc agtataattc tttctaggaa aatttgggaa gcgactttaa 2460
cacaaaaacg aggcagattt acttatttgc cattttctat gttaacatgc ttaattatgt 2520
tggaaactga atctttcttt ccagtaccac ttccgctgtc acggtaaagt ccgccatcag 2580
aagactgaag gagttgaaag accagtagac gctcctctac tctttgagac atcactggcc 2640
tataataaat gggttaattt atgtaacaaa a 2671
<210> 103
<211> 5895
<212> DNA
<213> Homo sapiens
<400> 103
agatgcaggg gcgcaaacgc caaaggagac caggctgtag gaagagaagg gcagagcgcc 60
ggacagctcg gcccgctccc cgtcctttgg ggccgcggct ggggaactac aaggcccagc 120
aggcagctgc agggggcgga ggcggaggag ggaccagcgc gggtgggagt gagagagcga 180
gccctcgcgc cccgccggcg catagcgctc ggagcgctct tgcggccaca ggcgcggcgt 240
cctcggcggc gggcggcagc tagcgggagc cgggacgccg gtgcagccgc agcgcgcgga 300
ggaacccggg tgtgccggga gctgggcggc cacgtccgga cgggaccgag acccctcgta 360
gcgcattgcg gcgacctcgc cttccccggc cgcgagcgcg ccgctgcttg aaaagccgcg 420
gaacccaagg acttttctcc ggtccgagct cggggcgccc cgcagggcgc acggtacccg 480
tgctgcagtc gggcacgccg cggcgccggg gcctccgcag ggcgatggag cccggtctgc 540
aaggaaagtg aggcgccgcc gctgcgttct ggaggagggg ggcacaaggt ctggagaccc 600
cgggtggcgg acgggagccc tccccccgcc ccgcctccgg ggcaccagct ccggctccat 660
tgttcccgcc cgggctggag gcgccgagca ccgagcgccg ccgggagtcg agcgccggcc 720
gcggagctct tgcgaccccg ccaggacccg aacagagccc gggggcggcg ggccggagcc 780
ggggacgcgg gcacacgccc gctcgcacaa gccacggcgg actctcccga ggcggaacct 840
ccacgccgag cgagggtcag tttgaaaagg aggatcgagc tcactgtgga gtatccatgg 900
agatgtggag ccttgtcacc aacctctaac tgcagaactg ggatgtggag ctggaagtgc 960
ctcctcttct gggctgtgct ggtcacagcc acactctgca ccgctaggcc gtccccgacc 1020
ttgcctgaac aagcccagcc ctggggagcc cctgtggaag tggagtcctt cctggtccac 1080
cccggtgacc tgctgcagct tcgctgtcgg ctgcgggacg atgtgcagag catcaactgg 1140
ctgcgggacg gggtgcagct ggcggaaagc aaccgcaccc gcatcacagg ggaggaggtg 1200
gaggtgcagg actccgtgcc cgcagactcc ggcctctatg cttgcgtaac cagcagcccc 1260
tcgggcagtg acaccaccta cttctccgtc aatgtttcag atgctctccc ctcctcggag 1320
gatgatgatg atgatgatga ctcctcttca gaggagaaag aaacagataa caccaaacca 1380
aaccgtatgc ccgtagctcc atattggaca tccccagaaa agatggaaaa gaaattgcat 1440
gcagtgccgg ctgccaagac agtgaagttc aaatgccctt ccagtgggac cccaaacccc 1500
acactgcgct ggttgaaaaa tggcaaagaa ttcaaacctg accacagaat tggaggctac 1560
aaggtccgtt atgccacctg gagcatcata atggactctg tggtgccctc tgacaagggc 1620
aactacacct gcattgtgga gaatgagtac ggcagcatca accacacata ccagctggat 1680
gtcgtggagc ggtcccctca ccggcccatc ctgcaagcag ggttgcccgc caacaaaaca 1740
gtggccctgg gtagcaacgt ggagttcatg tgtaaggtgt acagtgaccc gcagccgcac 1800
atccagtggc taaagcacat cgaggtgaat gggagcaaga ttggcccaga caacctgcct 1860
tatgtccaga tcttgaagac tgctggagtt aataccaccg acaaagagat ggaggtgctt 1920
cacttaagaa atgtctcctt tgaggacgca ggggagtata cgtgcttggc gggtaactct 1980
atcggactct cccatcactc tgcatggttg accgttctgg aagccctgga agagaggccg 2040
gcagtgatga cctcgcccct gtacctggag atcatcatct attgcacagg ggccttcctc 2100
atctcctgca tggtggggtc ggtcatcgtc tacaagatga agagtggtac caagaagagt 2160
gacttccaca gccagatggc tgtgcacaag ctggccaaga gcatccctct gcgcagacag 2220
gtgtctgctg actccagtgc atccatgaac tctggggttc ttctggttcg gccatcacgg 2280
ctctcctcca gtgggactcc catgctagca ggggtctctg agtatgagct tcccgaagac 2340
cctcgctggg agctgcctcg ggacagactg gtcttaggca aacccctggg agagggctgc 2400
tttgggcagg tggtgttggc agaggctatc gggctggaca aggacaaacc caaccgtgtg 2460
accaaagtgg ctgtgaagat gttgaagtcg gacgcaacag agaaagactt gtcagacctg 2520
atctcagaaa tggagatgat gaagatgatc gggaagcata agaatatcat caacctgctg 2580
ggggcctgca cgcaggatgg tcccttgtat gtcatcgtgg agtatgcctc caagggcaac 2640
ctgcgggagt acctgcaggc ccggaggccc ccagggctgg aatactgcta caaccccagc 2700
cacaacccag aggagcagct ctcctccaag gacctggtgt cctgcgccta ccaggtggcc 2760
cgaggcatgg agtatctggc ctccaagaag tgcatacacc gagacctggc agccaggaat 2820
gtcctggtga cagaggacaa tgtgatgaag atagcagact ttggcctcgc acgggacatt 2880
caccacatcg actactataa aaagacaacc aacggccgac tgcctgtgaa gtggatggca 2940
cccgaggcat tatttgaccg gatctacacc caccagagtg atgtgtggtc tttcggggtg 3000
ctcctgtggg agatcttcac tctgggcggc tccccatacc ccggtgtgcc tgtggaggaa 3060
cttttcaagc tgctgaagga gggtcaccgc atggacaagc ccagtaactg caccaacgag 3120
ctgtacatga tgatgcggga ctgctggcat gcagtgccct cacagagacc caccttcaag 3180
cagctggtgg aagacctgga ccgcatcgtg gccttgacct ccaaccagga gtacctggac 3240
ctgtccatgc ccctggacca gtactccccc agctttcccg acacccggag ctctacgtgc 3300
tcctcagggg aggattccgt cttctctcat gagccgctgc ccgaggagcc ctgcctgccc 3360
cgacacccag cccagcttgc caatggcgga ctcaaacgcc gctgactgcc acccacacgc 3420
cctccccaga ctccaccgtc agctgtaacc ctcacccaca gcccctgctg ggcccaccac 3480
ctgtccgtcc ctgtcccctt tcctgctggc aggagccggc tgcctaccag gggccttcct 3540
gtgtggcctg ccttcacccc actcagctca cctctccctc cacctcctct ccacctgctg 3600
gtgagaggtg caaagaggca gatctttgct gccagccact tcatcccctc ccagatgttg 3660
gaccaacacc cctccctgcc accaggcact gcctggaggg cagggagtgg gagccaatga 3720
acaggcatgc aagtgagagc ttcctgagct ttctcctgtc ggtttggtct gttttgcctt 3780
cacccataag cccctcgcac tctggtggca ggtgccttgt cctcagggct acagcagtag 3840
ggaggtcagt gcttcgtgcc tcgattgaag gtgacctctg ccccagatag gtggtgccag 3900
tggcttatta attccgatac tagtttgctt tgctgaccaa atgcctggta ccagaggatg 3960
gtgaggcgaa ggccaggttg ggggcagtgt tgtggccctg gggcccagcc ccaaactggg 4020
ggctctgtat atagctatga agaaaacaca aagtgtataa atctgagtat atatttacat 4080
gtctttttaa aagggtcgtt accagagatt tacccatcgg gtaagatgct cctggtggct 4140
gggaggcatc agttgctata tattaaaaac aaaaaagaaa aaaaaggaaa atgtttttaa 4200
aaaggtcata tattttttgc tacttttgct gttttatttt tttaaattat gttctaaacc 4260
tattttcagt ttaggtccct caataaaaat tgctgctgct tcatttatct atgggctgta 4320
tgaaaagggt gggaatgtcc actggaaaga agggacaccc acgggccctg gggctaggtc 4380
tgtcccgagg gcaccgcatg ctcccggcgc aggttccttg taacctcttc ttcctaggtc 4440
ctgcacccag acctcacgac gcacctcctg cctctccgct gcttttggaa agtcagaaaa 4500
agaagatgtc tgcttcgagg gcaggaaccc catccatgca gtagaggcgc tgggcagaga 4560
gtcaaggccc agcagccatc gaccatggat ggtttcctcc aaggaaaccg gtggggttgg 4620
gctggggagg gggcacctac ctaggaatag ccacggggta gagctacagt gattaagagg 4680
aaagcaaggg cgcggttgct cacgcctgta atcccagcac tttgggacac cgaggtgggc 4740
agatcacttc aggtcaggag tttgagacca gcctggccaa cttagtgaaa ccccatctct 4800
actaaaaatg caaaaattat ccaggcatgg tggcacacgc ctgtaatccc agctccacag 4860
gaggctgagg cagaatccct tgaagctggg aggcggaggt tgcagtgagc cgagattgcg 4920
ccattgcact ccagcctggg caacagagaa aacaaaaagg aaaacaaatg atgaaggtct 4980
gcagaaactg aaacccagac atgtgtctgc cccctctatg tgggcatggt tttgccagtg 5040
cttctaagtg caggagaaca tgtcacctga ggctagtttt gcattcaggt ccctggcttc 5100
gtttcttgtt ggtatgcctc cccagatcgt ccttcctgta tccatgtgac cagactgtat 5160
ttgttgggac tgtcgcagat cttggcttct tacagttctt cctgtccaaa ctccatcctg 5220
tccctcagga acggggggaa aattctccga atgtttttgg ttttttggct gcttggaatt 5280
tacttctgcc acctgctggt catcactgtc ctcactaagt ggattctggc tcccccgtac 5340
ctcatggctc aaactaccac tcctcagtcg ctatattaaa gcttatattt tgctggatta 5400
ctgctaaata caaaagaaag ttcaatatgt tttcatttct gtagggaaaa tgggattgct 5460
gctttaaatt tctgagctag ggattttttg gcagctgcag tgttggcgac tattgtaaaa 5520
ttctctttgt ttctctctgt aaatagcacc tgctaacatt acaatttgta tttatgttta 5580
aagaaggcat catttggtga acagaactag gaaatgaatt tttagctctt aaaagcattt 5640
gctttgagac cgcacaggag tgtctttcct tgtaaaacag tgatgataat ttctgccttg 5700
gccctacctt gaagcaatgt tgtgtgaagg gatgaagaat ctaaaagtct tcataagtcc 5760
ttgggagagg tgctagaaaa atataaggca ctatcataat tacagtgatg tccttgctgt 5820
tactactcaa atcacccaca aatttcccca aagactgcgc tagctgtcaa ataaaagaca 5880
gtgaaattga cctga 5895
<210> 104
<211> 5963
<212> DNA
<213> Homo sapiens
<400> 104
agatgcaggg gcgcaaacgc caaaggagac caggctgtag gaagagaagg gcagagcgcc 60
ggacagctcg gcccgctccc cgtcctttgg ggccgcggct ggggaactac aaggcccagc 120
aggcagctgc agggggcgga ggcggaggag ggaccagcgc gggtgggagt gagagagcga 180
gccctcgcgc cccgccggcg catagcgctc ggagcgctct tgcggccaca ggcgcggcgt 240
cctcggcggc gggcggcagc tagcgggagc cgggacgccg gtgcagccgc agcgcgcgga 300
ggaacccggg tgtgccggga gctgggcggc cacgtccgga cgggaccgag acccctcgta 360
gcgcattgcg gcgacctcgc cttccccggc cgcgagcgcg ccgctgcttg aaaagccgcg 420
gaacccaagg acttttctcc ggtccgagct cggggcgccc cgcagggcgc acggtacccg 480
tgctgcagtc gggcacgccg cggcgccggg gcctccgcag ggcgatggag cccggtctgc 540
aaggaaagtg aggcgccgcc gctgcgttct ggaggagggg ggcacaaggt ctggagaccc 600
cgggtggcgg acgggagccc tccccccgcc ccgcctccgg ggcaccagct ccggctccat 660
tgttcccgcc cgggctggag gcgccgagca ccgagcgccg ccgggagtcg agcgccggcc 720
gcggagctct tgcgaccccg ccaggacccg aacagagccc gggggcggcg ggccggagcc 780
ggggacgcgg gcacacgccc gctcgcacaa gccacggcgg actctcccga ggcggaacct 840
ccacgccgag cgagggtcag tttgaaaagg aggatcgagc tcactgtgga gtatccatgg 900
agatgtggag ccttgtcacc aacctctaac tgcagaactg ggatgtggag ctggaagtgc 960
ctcctcttct gggctgtgct ggtcacagcc acactctgca ccgctaggcc gtccccgacc 1020
ttgcctgaac aaggatggca gctgtgaccc gggatttcgg tgagatgctt ctgcactctg 1080
gccgggtcct gccagccgaa gcccagccct ggggagcccc tgtggaagtg gagtccttcc 1140
tggtccaccc cggtgacctg ctgcagcttc gctgtcggct gcgggacgat gtgcagagca 1200
tcaactggct gcgggacggg gtgcagctgg cggaaagcaa ccgcacccgc atcacagggg 1260
aggaggtgga ggtgcaggac tccgtgcccg cagactccgg cctctatgct tgcgtaacca 1320
gcagcccctc gggcagtgac accacctact tctccgtcaa tgtttcagat gctctcccct 1380
cctcggagga tgatgatgat gatgatgact cctcttcaga ggagaaagaa acagataaca 1440
ccaaaccaaa ccgtatgccc gtagctccat attggacatc cccagaaaag atggaaaaga 1500
aattgcatgc agtgccggct gccaagacag tgaagttcaa atgcccttcc agtgggaccc 1560
caaaccccac actgcgctgg ttgaaaaatg gcaaagaatt caaacctgac cacagaattg 1620
gaggctacaa ggtccgttat gccacctgga gcatcataat ggactctgtg gtgccctctg 1680
acaagggcaa ctacacctgc attgtggaga atgagtacgg cagcatcaac cacacatacc 1740
agctggatgt cgtggagcgg tcccctcacc ggcccatcct gcaagcaggg ttgcccgcca 1800
acaaaacagt ggccctgggt agcaacgtgg agttcatgtg taaggtgtac agtgacccgc 1860
agccgcacat ccagtggcta aagcacatcg aggtgaatgg gagcaagatt ggcccagaca 1920
acctgcctta tgtccagatc ttgaagactg ctggagttaa taccaccgac aaagagatgg 1980
aggtgcttca cttaagaaat gtctcctttg aggacgcagg ggagtatacg tgcttggcgg 2040
gtaactctat cggactctcc catcactctg catggttgac cgttctggaa gccctggaag 2100
agaggccggc agtgatgacc tcgcccctgt acctggagat catcatctat tgcacagggg 2160
ccttcctcat ctcctgcatg gtggggtcgg tcatcgtcta caagatgaag agtggtacca 2220
agaagagtga cttccacagc cagatggctg tgcacaagct ggccaagagc atccctctgc 2280
gcagacaggt gtctgctgac tccagtgcat ccatgaactc tggggttctt ctggttcggc 2340
catcacggct ctcctccagt gggactccca tgctagcagg ggtctctgag tatgagcttc 2400
ccgaagaccc tcgctgggag ctgcctcggg acagactggt cttaggcaaa cccctgggag 2460
agggctgctt tgggcaggtg gtgttggcag aggctatcgg gctggacaag gacaaaccca 2520
accgtgtgac caaagtggct gtgaagatgt tgaagtcgga cgcaacagag aaagacttgt 2580
cagacctgat ctcagaaatg gagatgatga agatgatcgg gaagcataag aatatcatca 2640
acctgctggg ggcctgcacg caggatggtc ccttgtatgt catcgtggag tatgcctcca 2700
agggcaacct gcgggagtac ctgcaggccc ggaggccccc agggctggaa tactgctaca 2760
accccagcca caacccagag gagcagctct cctccaagga cctggtgtcc tgcgcctacc 2820
aggtggcccg aggcatggag tatctggcct ccaagaagtg catacaccga gacctggcag 2880
ccaggaatgt cctggtgaca gaggacaatg tgatgaagat agcagacttt ggcctcgcac 2940
gggacattca ccacatcgac tactataaaa agacaaccaa cggccgactg cctgtgaagt 3000
ggatggcacc cgaggcatta tttgaccgga tctacaccca ccagagtgat gtgtggtctt 3060
tcggggtgct cctgtgggag atcttcactc tgggcggctc cccatacccc ggtgtgcctg 3120
tggaggaact tttcaagctg ctgaaggagg gtcaccgcat ggacaagccc agtaactgca 3180
ccaacgagct gtacatgatg atgcgggact gctggcatgc agtgccctca cagagaccca 3240
ccttcaagca gctggtggaa gacctggacc gcatcgtggc cttgacctcc aaccaggagt 3300
acctggacct gtccatgccc ctggaccagt actcccccag ctttcccgac acccggagct 3360
ctacgtgctc ctcaggggag gattccgtct tctctcatga gccgctgccc gaggagccct 3420
gcctgccccg acacccagcc cagcttgcca atggcggact caaacgccgc tgactgccac 3480
ccacacgccc tccccagact ccaccgtcag ctgtaaccct cacccacagc ccctgctggg 3540
cccaccacct gtccgtccct gtcccctttc ctgctggcag gagccggctg cctaccaggg 3600
gccttcctgt gtggcctgcc ttcaccccac tcagctcacc tctccctcca cctcctctcc 3660
acctgctggt gagaggtgca aagaggcaga tctttgctgc cagccacttc atcccctccc 3720
agatgttgga ccaacacccc tccctgccac caggcactgc ctggagggca gggagtggga 3780
gccaatgaac aggcatgcaa gtgagagctt cctgagcttt ctcctgtcgg tttggtctgt 3840
tttgccttca cccataagcc cctcgcactc tggtggcagg tgccttgtcc tcagggctac 3900
agcagtaggg aggtcagtgc ttcgtgcctc gattgaaggt gacctctgcc ccagataggt 3960
ggtgccagtg gcttattaat tccgatacta gtttgctttg ctgaccaaat gcctggtacc 4020
agaggatggt gaggcgaagg ccaggttggg ggcagtgttg tggccctggg gcccagcccc 4080
aaactggggg ctctgtatat agctatgaag aaaacacaaa gtgtataaat ctgagtatat 4140
atttacatgt ctttttaaaa gggtcgttac cagagattta cccatcgggt aagatgctcc 4200
tggtggctgg gaggcatcag ttgctatata ttaaaaacaa aaaagaaaaa aaaggaaaat 4260
gtttttaaaa aggtcatata ttttttgcta cttttgctgt tttatttttt taaattatgt 4320
tctaaaccta ttttcagttt aggtccctca ataaaaattg ctgctgcttc atttatctat 4380
gggctgtatg aaaagggtgg gaatgtccac tggaaagaag ggacacccac gggccctggg 4440
gctaggtctg tcccgagggc accgcatgct cccggcgcag gttccttgta acctcttctt 4500
cctaggtcct gcacccagac ctcacgacgc acctcctgcc tctccgctgc ttttggaaag 4560
tcagaaaaag aagatgtctg cttcgagggc aggaacccca tccatgcagt agaggcgctg 4620
ggcagagagt caaggcccag cagccatcga ccatggatgg tttcctccaa ggaaaccggt 4680
ggggttgggc tggggagggg gcacctacct aggaatagcc acggggtaga gctacagtga 4740
ttaagaggaa agcaagggcg cggttgctca cgcctgtaat cccagcactt tgggacaccg 4800
aggtgggcag atcacttcag gtcaggagtt tgagaccagc ctggccaact tagtgaaacc 4860
ccatctctac taaaaatgca aaaattatcc aggcatggtg gcacacgcct gtaatcccag 4920
ctccacagga ggctgaggca gaatcccttg aagctgggag gcggaggttg cagtgagccg 4980
agattgcgcc attgcactcc agcctgggca acagagaaaa caaaaaggaa aacaaatgat 5040
gaaggtctgc agaaactgaa acccagacat gtgtctgccc cctctatgtg ggcatggttt 5100
tgccagtgct tctaagtgca ggagaacatg tcacctgagg ctagttttgc attcaggtcc 5160
ctggcttcgt ttcttgttgg tatgcctccc cagatcgtcc ttcctgtatc catgtgacca 5220
gactgtattt gttgggactg tcgcagatct tggcttctta cagttcttcc tgtccaaact 5280
ccatcctgtc cctcaggaac ggggggaaaa ttctccgaat gtttttggtt ttttggctgc 5340
ttggaattta cttctgccac ctgctggtca tcactgtcct cactaagtgg attctggctc 5400
ccccgtacct catggctcaa actaccactc ctcagtcgct atattaaagc ttatattttg 5460
ctggattact gctaaataca aaagaaagtt caatatgttt tcatttctgt agggaaaatg 5520
ggattgctgc tttaaatttc tgagctaggg attttttggc agctgcagtg ttggcgacta 5580
ttgtaaaatt ctctttgttt ctctctgtaa atagcacctg ctaacattac aatttgtatt 5640
tatgtttaaa gaaggcatca tttggtgaac agaactagga aatgaatttt tagctcttaa 5700
aagcatttgc tttgagaccg cacaggagtg tctttccttg taaaacagtg atgataattt 5760
ctgccttggc cctaccttga agcaatgttg tgtgaaggga tgaagaatct aaaagtcttc 5820
ataagtcctt gggagaggtg ctagaaaaat ataaggcact atcataatta cagtgatgtc 5880
cttgctgtta ctactcaaat cacccacaaa tttccccaaa gactgcgcta gctgtcaaat 5940
aaaagacagt gaaattgacc tga 5963
<210> 105
<211> 5215
<212> DNA
<213> Homo sapiens
<400> 105
ccctttcacc tcctggctcc ctcccgggcg atccgcgccc cttgggtctc ccctcccttc 60
cctccgtccg cgtctcctgc gccccctccc tgcgctcgtc ccgccgctct tcccgccgcc 120
caacttttcc tccaactcgc gctcgggagc tggcgaggcg gcggcggctc ctcaggtcag 180
tttgaaaagg aggatcgagc tcactgtgga gtatccatgg agatgtggag ccttgtcacc 240
aacctctaac tgcagaactg ggatgtggag ctggaagtgc ctcctcttct gggctgtgct 300
ggtcacagcc acactctgca ccgctaggcc gtccccgacc ttgcctgaac aagcccagcc 360
ctggggagcc cctgtggaag tggagtcctt cctggtccac cccggtgacc tgctgcagct 420
tcgctgtcgg ctgcgggacg atgtgcagag catcaactgg ctgcgggacg gggtgcagct 480
ggcggaaagc aaccgcaccc gcatcacagg ggaggaggtg gaggtgcagg actccgtgcc 540
cgcagactcc ggcctctatg cttgcgtaac cagcagcccc tcgggcagtg acaccaccta 600
cttctccgtc aatgtttcag atgctctccc ctcctcggag gatgatgatg atgatgatga 660
ctcctcttca gaggagaaag aaacagataa caccaaacca aaccccgtag ctccatattg 720
gacatcccca gaaaagatgg aaaagaaatt gcatgcagtg ccggctgcca agacagtgaa 780
gttcaaatgc ccttccagtg ggaccccaaa ccccacactg cgctggttga aaaatggcaa 840
agaattcaaa cctgaccaca gaattggagg ctacaaggtc cgttatgcca cctggagcat 900
cataatggac tctgtggtgc cctctgacaa gggcaactac acctgcattg tggagaatga 960
gtacggcagc atcaaccaca cataccagct ggatgtcgtg gagcggtccc ctcaccggcc 1020
catcctgcaa gcagggttgc ccgccaacaa aacagtggcc ctgggtagca acgtggagtt 1080
catgtgtaag gtgtacagtg acccgcagcc gcacatccag tggctaaagc acatcgaggt 1140
gaatgggagc aagattggcc cagacaacct gccttatgtc cagatcttga agactgctgg 1200
agttaatacc accgacaaag agatggaggt gcttcactta agaaatgtct cctttgagga 1260
cgcaggggag tatacgtgct tggcgggtaa ctctatcgga ctctcccatc actctgcatg 1320
gttgaccgtt ctggaagccc tggaagagag gccggcagtg atgacctcgc ccctgtacct 1380
ggagatcatc atctattgca caggggcctt cctcatctcc tgcatggtgg ggtcggtcat 1440
cgtctacaag atgaagagtg gtaccaagaa gagtgacttc cacagccaga tggctgtgca 1500
caagctggcc aagagcatcc ctctgcgcag acaggtaaca gtgtctgctg actccagtgc 1560
atccatgaac tctggggttc ttctggttcg gccatcacgg ctctcctcca gtgggactcc 1620
catgctagca ggggtctctg agtatgagct tcccgaagac cctcgctggg agctgcctcg 1680
ggacagactg gtcttaggca aacccctggg agagggctgc tttgggcagg tggtgttggc 1740
agaggctatc gggctggaca aggacaaacc caaccgtgtg accaaagtgg ctgtgaagat 1800
gttgaagtcg gacgcaacag agaaagactt gtcagacctg atctcagaaa tggagatgat 1860
gaagatgatc gggaagcata agaatatcat caacctgctg ggggcctgca cgcaggatgg 1920
tcccttgtat gtcatcgtgg agtatgcctc caagggcaac ctgcgggagt acctgcaggc 1980
ccggaggccc ccagggctgg aatactgcta caaccccagc cacaacccag aggagcagct 2040
ctcctccaag gacctggtgt cctgcgccta ccaggtggcc cgaggcatgg agtatctggc 2100
ctccaagaag tgcatacacc gagacctggc agccaggaat gtcctggtga cagaggacaa 2160
tgtgatgaag atagcagact ttggcctcgc acgggacatt caccacatcg actactataa 2220
aaagacaacc aacggccgac tgcctgtgaa gtggatggca cccgaggcat tatttgaccg 2280
gatctacacc caccagagtg atgtgtggtc tttcggggtg ctcctgtggg agatcttcac 2340
tctgggcggc tccccatacc ccggtgtgcc tgtggaggaa cttttcaagc tgctgaagga 2400
gggtcaccgc atggacaagc ccagtaactg caccaacgag ctgtacatga tgatgcggga 2460
ctgctggcat gcagtgccct cacagagacc caccttcaag cagctggtgg aagacctgga 2520
ccgcatcgtg gccttgacct ccaaccagga gtacctggac ctgtccatgc ccctggacca 2580
gtactccccc agctttcccg acacccggag ctctacgtgc tcctcagggg aggattccgt 2640
cttctctcat gagccgctgc ccgaggagcc ctgcctgccc cgacacccag cccagcttgc 2700
caatggcgga ctcaaacgcc gctgactgcc acccacacgc cctccccaga ctccaccgtc 2760
agctgtaacc ctcacccaca gcccctgctg ggcccaccac ctgtccgtcc ctgtcccctt 2820
tcctgctggc aggagccggc tgcctaccag gggccttcct gtgtggcctg ccttcacccc 2880
actcagctca cctctccctc cacctcctct ccacctgctg gtgagaggtg caaagaggca 2940
gatctttgct gccagccact tcatcccctc ccagatgttg gaccaacacc cctccctgcc 3000
accaggcact gcctggaggg cagggagtgg gagccaatga acaggcatgc aagtgagagc 3060
ttcctgagct ttctcctgtc ggtttggtct gttttgcctt cacccataag cccctcgcac 3120
tctggtggca ggtgccttgt cctcagggct acagcagtag ggaggtcagt gcttcgtgcc 3180
tcgattgaag gtgacctctg ccccagatag gtggtgccag tggcttatta attccgatac 3240
tagtttgctt tgctgaccaa atgcctggta ccagaggatg gtgaggcgaa ggccaggttg 3300
ggggcagtgt tgtggccctg gggcccagcc ccaaactggg ggctctgtat atagctatga 3360
agaaaacaca aagtgtataa atctgagtat atatttacat gtctttttaa aagggtcgtt 3420
accagagatt tacccatcgg gtaagatgct cctggtggct gggaggcatc agttgctata 3480
tattaaaaac aaaaaagaaa aaaaaggaaa atgtttttaa aaaggtcata tattttttgc 3540
tacttttgct gttttatttt tttaaattat gttctaaacc tattttcagt ttaggtccct 3600
caataaaaat tgctgctgct tcatttatct atgggctgta tgaaaagggt gggaatgtcc 3660
actggaaaga agggacaccc acgggccctg gggctaggtc tgtcccgagg gcaccgcatg 3720
ctcccggcgc aggttccttg taacctcttc ttcctaggtc ctgcacccag acctcacgac 3780
gcacctcctg cctctccgct gcttttggaa agtcagaaaa agaagatgtc tgcttcgagg 3840
gcaggaaccc catccatgca gtagaggcgc tgggcagaga gtcaaggccc agcagccatc 3900
gaccatggat ggtttcctcc aaggaaaccg gtggggttgg gctggggagg gggcacctac 3960
ctaggaatag ccacggggta gagctacagt gattaagagg aaagcaaggg cgcggttgct 4020
cacgcctgta atcccagcac tttgggacac cgaggtgggc agatcacttc aggtcaggag 4080
tttgagacca gcctggccaa cttagtgaaa ccccatctct actaaaaatg caaaaattat 4140
ccaggcatgg tggcacacgc ctgtaatccc agctccacag gaggctgagg cagaatccct 4200
tgaagctggg aggcggaggt tgcagtgagc cgagattgcg ccattgcact ccagcctggg 4260
caacagagaa aacaaaaagg aaaacaaatg atgaaggtct gcagaaactg aaacccagac 4320
atgtgtctgc cccctctatg tgggcatggt tttgccagtg cttctaagtg caggagaaca 4380
tgtcacctga ggctagtttt gcattcaggt ccctggcttc gtttcttgtt ggtatgcctc 4440
cccagatcgt ccttcctgta tccatgtgac cagactgtat ttgttgggac tgtcgcagat 4500
cttggcttct tacagttctt cctgtccaaa ctccatcctg tccctcagga acggggggaa 4560
aattctccga atgtttttgg ttttttggct gcttggaatt tacttctgcc acctgctggt 4620
catcactgtc ctcactaagt ggattctggc tcccccgtac ctcatggctc aaactaccac 4680
tcctcagtcg ctatattaaa gcttatattt tgctggatta ctgctaaata caaaagaaag 4740
ttcaatatgt tttcatttct gtagggaaaa tgggattgct gctttaaatt tctgagctag 4800
ggattttttg gcagctgcag tgttggcgac tattgtaaaa ttctctttgt ttctctctgt 4860
aaatagcacc tgctaacatt acaatttgta tttatgttta aagaaggcat catttggtga 4920
acagaactag gaaatgaatt tttagctctt aaaagcattt gctttgagac cgcacaggag 4980
tgtctttcct tgtaaaacag tgatgataat ttctgccttg gccctacctt gaagcaatgt 5040
tgtgtgaagg gatgaagaat ctaaaagtct tcataagtcc ttgggagagg tgctagaaaa 5100
atataaggca ctatcataat tacagtgatg tccttgctgt tactactcaa atcacccaca 5160
aatttcccca aagactgcgc tagctgtcaa ataaaagaca gtgaaattga cctga 5215
<210> 106
<211> 4954
<212> DNA
<213> Homo sapiens
<400> 106
ccctttcacc tcctggctcc ctcccgggcg atccgcgccc cttgggtctc ccctcccttc 60
cctccgtccg cgtctcctgc gccccctccc tgcgctcgtc ccgccgctct tcccgccgcc 120
caacttttcc tccaactcgc gctcgggagc tggcgaggcg gcggcggctc ctcaggtcag 180
tttgaaaagg aggatcgagc tcactgtgga gtatccatgg agatgtggag ccttgtcacc 240
aacctctaac tgcagaactg ggatgtggag ctggaagtgc ctcctcttct gggctgtgct 300
ggtcacagcc acactctgca ccgctaggcc gtccccgacc ttgcctgaac aagatgctct 360
cccctcctcg gaggatgatg atgatgatga tgactcctct tcagaggaga aagaaacaga 420
taacaccaaa ccaaaccgta tgcccgtagc tccatattgg acatccccag aaaagatgga 480
aaagaaattg catgcagtgc cggctgccaa gacagtgaag ttcaaatgcc cttccagtgg 540
gaccccaaac cccacactgc gctggttgaa aaatggcaaa gaattcaaac ctgaccacag 600
aattggaggc tacaaggtcc gttatgccac ctggagcatc ataatggact ctgtggtgcc 660
ctctgacaag ggcaactaca cctgcattgt ggagaatgag tacggcagca tcaaccacac 720
ataccagctg gatgtcgtgg agcggtcccc tcaccggccc atcctgcaag cagggttgcc 780
cgccaacaaa acagtggccc tgggtagcaa cgtggagttc atgtgtaagg tgtacagtga 840
cccgcagccg cacatccagt ggctaaagca catcgaggtg aatgggagca agattggccc 900
agacaacctg ccttatgtcc agatcttgaa gactgctgga gttaatacca ccgacaaaga 960
gatggaggtg cttcacttaa gaaatgtctc ctttgaggac gcaggggagt atacgtgctt 1020
ggcgggtaac tctatcggac tctcccatca ctctgcatgg ttgaccgttc tggaagccct 1080
ggaagagagg ccggcagtga tgacctcgcc cctgtacctg gagatcatca tctattgcac 1140
aggggccttc ctcatctcct gcatggtggg gtcggtcatc gtctacaaga tgaagagtgg 1200
taccaagaag agtgacttcc acagccagat ggctgtgcac aagctggcca agagcatccc 1260
tctgcgcaga caggtaacag tgtctgctga ctccagtgca tccatgaact ctggggttct 1320
tctggttcgg ccatcacggc tctcctccag tgggactccc atgctagcag gggtctctga 1380
gtatgagctt cccgaagacc ctcgctggga gctgcctcgg gacagactgg tcttaggcaa 1440
acccctggga gagggctgct ttgggcaggt ggtgttggca gaggctatcg ggctggacaa 1500
ggacaaaccc aaccgtgtga ccaaagtggc tgtgaagatg ttgaagtcgg acgcaacaga 1560
gaaagacttg tcagacctga tctcagaaat ggagatgatg aagatgatcg ggaagcataa 1620
gaatatcatc aacctgctgg gggcctgcac gcaggatggt cccttgtatg tcatcgtgga 1680
gtatgcctcc aagggcaacc tgcgggagta cctgcaggcc cggaggcccc cagggctgga 1740
atactgctac aaccccagcc acaacccaga ggagcagctc tcctccaagg acctggtgtc 1800
ctgcgcctac caggtggccc gaggcatgga gtatctggcc tccaagaagt gcatacaccg 1860
agacctggca gccaggaatg tcctggtgac agaggacaat gtgatgaaga tagcagactt 1920
tggcctcgca cgggacattc accacatcga ctactataaa aagacaacca acggccgact 1980
gcctgtgaag tggatggcac ccgaggcatt atttgaccgg atctacaccc accagagtga 2040
tgtgtggtct ttcggggtgc tcctgtggga gatcttcact ctgggcggct ccccataccc 2100
cggtgtgcct gtggaggaac ttttcaagct gctgaaggag ggtcaccgca tggacaagcc 2160
cagtaactgc accaacgagc tgtacatgat gatgcgggac tgctggcatg cagtgccctc 2220
acagagaccc accttcaagc agctggtgga agacctggac cgcatcgtgg ccttgacctc 2280
caaccaggag tacctggacc tgtccatgcc cctggaccag tactccccca gctttcccga 2340
cacccggagc tctacgtgct cctcagggga ggattccgtc ttctctcatg agccgctgcc 2400
cgaggagccc tgcctgcccc gacacccagc ccagcttgcc aatggcggac tcaaacgccg 2460
ctgactgcca cccacacgcc ctccccagac tccaccgtca gctgtaaccc tcacccacag 2520
cccctgctgg gcccaccacc tgtccgtccc tgtccccttt cctgctggca ggagccggct 2580
gcctaccagg ggccttcctg tgtggcctgc cttcacccca ctcagctcac ctctccctcc 2640
acctcctctc cacctgctgg tgagaggtgc aaagaggcag atctttgctg ccagccactt 2700
catcccctcc cagatgttgg accaacaccc ctccctgcca ccaggcactg cctggagggc 2760
agggagtggg agccaatgaa caggcatgca agtgagagct tcctgagctt tctcctgtcg 2820
gtttggtctg ttttgccttc acccataagc ccctcgcact ctggtggcag gtgccttgtc 2880
ctcagggcta cagcagtagg gaggtcagtg cttcgtgcct cgattgaagg tgacctctgc 2940
cccagatagg tggtgccagt ggcttattaa ttccgatact agtttgcttt gctgaccaaa 3000
tgcctggtac cagaggatgg tgaggcgaag gccaggttgg gggcagtgtt gtggccctgg 3060
ggcccagccc caaactgggg gctctgtata tagctatgaa gaaaacacaa agtgtataaa 3120
tctgagtata tatttacatg tctttttaaa agggtcgtta ccagagattt acccatcggg 3180
taagatgctc ctggtggctg ggaggcatca gttgctatat attaaaaaca aaaaagaaaa 3240
aaaaggaaaa tgtttttaaa aaggtcatat attttttgct acttttgctg ttttattttt 3300
ttaaattatg ttctaaacct attttcagtt taggtccctc aataaaaatt gctgctgctt 3360
catttatcta tgggctgtat gaaaagggtg ggaatgtcca ctggaaagaa gggacaccca 3420
cgggccctgg ggctaggtct gtcccgaggg caccgcatgc tcccggcgca ggttccttgt 3480
aacctcttct tcctaggtcc tgcacccaga cctcacgacg cacctcctgc ctctccgctg 3540
cttttggaaa gtcagaaaaa gaagatgtct gcttcgaggg caggaacccc atccatgcag 3600
tagaggcgct gggcagagag tcaaggccca gcagccatcg accatggatg gtttcctcca 3660
aggaaaccgg tggggttggg ctggggaggg ggcacctacc taggaatagc cacggggtag 3720
agctacagtg attaagagga aagcaagggc gcggttgctc acgcctgtaa tcccagcact 3780
ttgggacacc gaggtgggca gatcacttca ggtcaggagt ttgagaccag cctggccaac 3840
ttagtgaaac cccatctcta ctaaaaatgc aaaaattatc caggcatggt ggcacacgcc 3900
tgtaatccca gctccacagg aggctgaggc agaatccctt gaagctggga ggcggaggtt 3960
gcagtgagcc gagattgcgc cattgcactc cagcctgggc aacagagaaa acaaaaagga 4020
aaacaaatga tgaaggtctg cagaaactga aacccagaca tgtgtctgcc ccctctatgt 4080
gggcatggtt ttgccagtgc ttctaagtgc aggagaacat gtcacctgag gctagttttg 4140
cattcaggtc cctggcttcg tttcttgttg gtatgcctcc ccagatcgtc cttcctgtat 4200
ccatgtgacc agactgtatt tgttgggact gtcgcagatc ttggcttctt acagttcttc 4260
ctgtccaaac tccatcctgt ccctcaggaa cggggggaaa attctccgaa tgtttttggt 4320
tttttggctg cttggaattt acttctgcca cctgctggtc atcactgtcc tcactaagtg 4380
gattctggct cccccgtacc tcatggctca aactaccact cctcagtcgc tatattaaag 4440
cttatatttt gctggattac tgctaaatac aaaagaaagt tcaatatgtt ttcatttctg 4500
tagggaaaat gggattgctg ctttaaattt ctgagctagg gattttttgg cagctgcagt 4560
gttggcgact attgtaaaat tctctttgtt tctctctgta aatagcacct gctaacatta 4620
caatttgtat ttatgtttaa agaaggcatc atttggtgaa cagaactagg aaatgaattt 4680
ttagctctta aaagcatttg ctttgagacc gcacaggagt gtctttcctt gtaaaacagt 4740
gatgataatt tctgccttgg ccctaccttg aagcaatgtt gtgtgaaggg atgaagaatc 4800
taaaagtctt cataagtcct tgggagaggt gctagaaaaa tataaggcac tatcataatt 4860
acagtgatgt ccttgctgtt actactcaaa tcacccacaa atttccccaa agactgcgct 4920
agctgtcaaa taaaagacag tgaaattgac ctga 4954
<210> 107
<211> 5375
<212> DNA
<213> Homo sapiens
<400> 107
ccctttcacc tcctggctcc ctcccgggcg atccgcgccc cttgggtctc ccctcccttc 60
cctccgtccg cgtctcctgc gccccctccc tgcgctcgtc ccgccgctct tcccgccgcc 120
caacttttcc tccaactcgc gctcgggagc tggcgaggcg gcggcggctc ctcaaagtgg 180
gagagcttca aggtcacgtg gtccgtccag cccctgctat ctcaccagac actgtccacc 240
ctgtatgttg gatcagtact ccagtgagaa gacagcaggc actttcaccc atgcagccca 300
ttcagtcttc ataaccacct gtgatggagg caagggtcag tttgaaaagg aggatcgagc 360
tcactgtgga gtatccatgg agatgtggag ccttgtcacc aacctctaac tgcagaactg 420
ggatgtggag ctggaagtgc ctcctcttct gggctgtgct ggtcacagcc acactctgca 480
ccgctaggcc gtccccgacc ttgcctgaac aagcccagcc ctggggagcc cctgtggaag 540
tggagtcctt cctggtccac cccggtgacc tgctgcagct tcgctgtcgg ctgcgggacg 600
atgtgcagag catcaactgg ctgcgggacg gggtgcagct ggcggaaagc aaccgcaccc 660
gcatcacagg ggaggaggtg gaggtgcagg actccgtgcc cgcagactcc ggcctctatg 720
cttgcgtaac cagcagcccc tcgggcagtg acaccaccta cttctccgtc aatgtttcag 780
atgctctccc ctcctcggag gatgatgatg atgatgatga ctcctcttca gaggagaaag 840
aaacagataa caccaaacca aaccccgtag ctccatattg gacatcccca gaaaagatgg 900
aaaagaaatt gcatgcagtg ccggctgcca agacagtgaa gttcaaatgc ccttccagtg 960
ggaccccaaa ccccacactg cgctggttga aaaatggcaa agaattcaaa cctgaccaca 1020
gaattggagg ctacaaggtc cgttatgcca cctggagcat cataatggac tctgtggtgc 1080
cctctgacaa gggcaactac acctgcattg tggagaatga gtacggcagc atcaaccaca 1140
cataccagct ggatgtcgtg gagcggtccc ctcaccggcc catcctgcaa gcagggttgc 1200
ccgccaacaa aacagtggcc ctgggtagca acgtggagtt catgtgtaag gtgtacagtg 1260
acccgcagcc gcacatccag tggctaaagc acatcgaggt gaatgggagc aagattggcc 1320
cagacaacct gccttatgtc cagatcttga agactgctgg agttaatacc accgacaaag 1380
agatggaggt gcttcactta agaaatgtct cctttgagga cgcaggggag tatacgtgct 1440
tggcgggtaa ctctatcgga ctctcccatc actctgcatg gttgaccgtt ctggaagccc 1500
tggaagagag gccggcagtg atgacctcgc ccctgtacct ggagatcatc atctattgca 1560
caggggcctt cctcatctcc tgcatggtgg ggtcggtcat cgtctacaag atgaagagtg 1620
gtaccaagaa gagtgacttc cacagccaga tggctgtgca caagctggcc aagagcatcc 1680
ctctgcgcag acaggtaaca gtgtctgctg actccagtgc atccatgaac tctggggttc 1740
ttctggttcg gccatcacgg ctctcctcca gtgggactcc catgctagca ggggtctctg 1800
agtatgagct tcccgaagac cctcgctggg agctgcctcg ggacagactg gtcttaggca 1860
aacccctggg agagggctgc tttgggcagg tggtgttggc agaggctatc gggctggaca 1920
aggacaaacc caaccgtgtg accaaagtgg ctgtgaagat gttgaagtcg gacgcaacag 1980
agaaagactt gtcagacctg atctcagaaa tggagatgat gaagatgatc gggaagcata 2040
agaatatcat caacctgctg ggggcctgca cgcaggatgg tcccttgtat gtcatcgtgg 2100
agtatgcctc caagggcaac ctgcgggagt acctgcaggc ccggaggccc ccagggctgg 2160
aatactgcta caaccccagc cacaacccag aggagcagct ctcctccaag gacctggtgt 2220
cctgcgccta ccaggtggcc cgaggcatgg agtatctggc ctccaagaag tgcatacacc 2280
gagacctggc agccaggaat gtcctggtga cagaggacaa tgtgatgaag atagcagact 2340
ttggcctcgc acgggacatt caccacatcg actactataa aaagacaacc aacggccgac 2400
tgcctgtgaa gtggatggca cccgaggcat tatttgaccg gatctacacc caccagagtg 2460
atgtgtggtc tttcggggtg ctcctgtggg agatcttcac tctgggcggc tccccatacc 2520
ccggtgtgcc tgtggaggaa cttttcaagc tgctgaagga gggtcaccgc atggacaagc 2580
ccagtaactg caccaacgag ctgtacatga tgatgcggga ctgctggcat gcagtgccct 2640
cacagagacc caccttcaag cagctggtgg aagacctgga ccgcatcgtg gccttgacct 2700
ccaaccagga gtacctggac ctgtccatgc ccctggacca gtactccccc agctttcccg 2760
acacccggag ctctacgtgc tcctcagggg aggattccgt cttctctcat gagccgctgc 2820
ccgaggagcc ctgcctgccc cgacacccag cccagcttgc caatggcgga ctcaaacgcc 2880
gctgactgcc acccacacgc cctccccaga ctccaccgtc agctgtaacc ctcacccaca 2940
gcccctgctg ggcccaccac ctgtccgtcc ctgtcccctt tcctgctggc aggagccggc 3000
tgcctaccag gggccttcct gtgtggcctg ccttcacccc actcagctca cctctccctc 3060
cacctcctct ccacctgctg gtgagaggtg caaagaggca gatctttgct gccagccact 3120
tcatcccctc ccagatgttg gaccaacacc cctccctgcc accaggcact gcctggaggg 3180
cagggagtgg gagccaatga acaggcatgc aagtgagagc ttcctgagct ttctcctgtc 3240
ggtttggtct gttttgcctt cacccataag cccctcgcac tctggtggca ggtgccttgt 3300
cctcagggct acagcagtag ggaggtcagt gcttcgtgcc tcgattgaag gtgacctctg 3360
ccccagatag gtggtgccag tggcttatta attccgatac tagtttgctt tgctgaccaa 3420
atgcctggta ccagaggatg gtgaggcgaa ggccaggttg ggggcagtgt tgtggccctg 3480
gggcccagcc ccaaactggg ggctctgtat atagctatga agaaaacaca aagtgtataa 3540
atctgagtat atatttacat gtctttttaa aagggtcgtt accagagatt tacccatcgg 3600
gtaagatgct cctggtggct gggaggcatc agttgctata tattaaaaac aaaaaagaaa 3660
aaaaaggaaa atgtttttaa aaaggtcata tattttttgc tacttttgct gttttatttt 3720
tttaaattat gttctaaacc tattttcagt ttaggtccct caataaaaat tgctgctgct 3780
tcatttatct atgggctgta tgaaaagggt gggaatgtcc actggaaaga agggacaccc 3840
acgggccctg gggctaggtc tgtcccgagg gcaccgcatg ctcccggcgc aggttccttg 3900
taacctcttc ttcctaggtc ctgcacccag acctcacgac gcacctcctg cctctccgct 3960
gcttttggaa agtcagaaaa agaagatgtc tgcttcgagg gcaggaaccc catccatgca 4020
gtagaggcgc tgggcagaga gtcaaggccc agcagccatc gaccatggat ggtttcctcc 4080
aaggaaaccg gtggggttgg gctggggagg gggcacctac ctaggaatag ccacggggta 4140
gagctacagt gattaagagg aaagcaaggg cgcggttgct cacgcctgta atcccagcac 4200
tttgggacac cgaggtgggc agatcacttc aggtcaggag tttgagacca gcctggccaa 4260
cttagtgaaa ccccatctct actaaaaatg caaaaattat ccaggcatgg tggcacacgc 4320
ctgtaatccc agctccacag gaggctgagg cagaatccct tgaagctggg aggcggaggt 4380
tgcagtgagc cgagattgcg ccattgcact ccagcctggg caacagagaa aacaaaaagg 4440
aaaacaaatg atgaaggtct gcagaaactg aaacccagac atgtgtctgc cccctctatg 4500
tgggcatggt tttgccagtg cttctaagtg caggagaaca tgtcacctga ggctagtttt 4560
gcattcaggt ccctggcttc gtttcttgtt ggtatgcctc cccagatcgt ccttcctgta 4620
tccatgtgac cagactgtat ttgttgggac tgtcgcagat cttggcttct tacagttctt 4680
cctgtccaaa ctccatcctg tccctcagga acggggggaa aattctccga atgtttttgg 4740
ttttttggct gcttggaatt tacttctgcc acctgctggt catcactgtc ctcactaagt 4800
ggattctggc tcccccgtac ctcatggctc aaactaccac tcctcagtcg ctatattaaa 4860
gcttatattt tgctggatta ctgctaaata caaaagaaag ttcaatatgt tttcatttct 4920
gtagggaaaa tgggattgct gctttaaatt tctgagctag ggattttttg gcagctgcag 4980
tgttggcgac tattgtaaaa ttctctttgt ttctctctgt aaatagcacc tgctaacatt 5040
acaatttgta tttatgttta aagaaggcat catttggtga acagaactag gaaatgaatt 5100
tttagctctt aaaagcattt gctttgagac cgcacaggag tgtctttcct tgtaaaacag 5160
tgatgataat ttctgccttg gccctacctt gaagcaatgt tgtgtgaagg gatgaagaat 5220
ctaaaagtct tcataagtcc ttgggagagg tgctagaaaa atataaggca ctatcataat 5280
tacagtgatg tccttgctgt tactactcaa atcacccaca aatttcccca aagactgcgc 5340
tagctgtcaa ataaaagaca gtgaaattga cctga 5375
<210> 108
<211> 5917
<212> DNA
<213> Homo sapiens
<400> 108
agatgcaggg gcgcaaacgc caaaggagac caggctgtag gaagagaagg gcagagcgcc 60
ggacagctcg gcccgctccc cgtcctttgg ggccgcggct ggggaactac aaggcccagc 120
aggcagctgc agggggcgga ggcggaggag ggaccagcgc gggtgggagt gagagagcga 180
gccctcgcgc cccgccggcg catagcgctc ggagcgctct tgcggccaca ggcgcggcgt 240
cctcggcggc gggcggcagc tagcgggagc cgggacgccg gtgcagccgc agcgcgcgga 300
ggaacccggg tgtgccggga gctgggcggc cacgtccgga cgggaccgag acccctcgta 360
gcgcattgcg gcgacctcgc cttccccggc cgcgagcgcg ccgctgcttg aaaagccgcg 420
gaacccaagg acttttctcc ggtccgagct cggggcgccc cgcagggcgc acggtacccg 480
tgctgcagtc gggcacgccg cggcgccggg gcctccgcag ggcgatggag cccggtctgc 540
aaggaaagtg aggcgccgcc gctgcgttct ggaggagggg ggcacaaggt ctggagaccc 600
cgggtggcgg acgggagccc tccccccgcc ccgcctccgg ggcaccagct ccggctccat 660
tgttcccgcc cgggctggag gcgccgagca ccgagcgccg ccgggagtcg agcgccggcc 720
gcggagctct tgcgaccccg ccaggacccg aacagagccc gggggcggcg ggccggagcc 780
ggggacgcgg gcacacgccc gctcgcacaa gccacggcgg actctcccga ggcggaacct 840
ccacgccgag cgagggtcag tttgaaaagg aggatcgagc tcactgtgga gtatccatgg 900
agatgtggag ccttgtcacc aacctctaac tgcagaactg ggatgtggag ctggaagtgc 960
ctcctcttct gggctgtgct ggtcacagcc acactctgca ccgctaggcc gtccccgacc 1020
ttgcctgaac aagcccagcc ctggggagcc cctgtggaag tggagtcctt cctggtccac 1080
cccggtgacc tgctgcagct tcgctgtcgg ctgcgggacg atgtgcagag catcaactgg 1140
ctgcgggacg gggtgcagct ggcggaaagc aaccgcaccc gcatcacagg ggaggaggtg 1200
gaggtgcagg actccgtgcc cgcagactcc ggcctctatg cttgcgtaac cagcagcccc 1260
tcgggcagtg acaccaccta cttctccgtc aatgtttcag atgctctccc ctcctcggag 1320
gatgatgatg atgatgatga ctcctcttca gaggagaaag aaacagataa caccaaacca 1380
aaccgtatgc ccgtagctcc atattggaca tccccagaaa agatggaaaa gaaattgcat 1440
gcagtgccgg ctgccaagac agtgaagttc aaatgccctt ccagtgggac cccaaacccc 1500
acactgcgct ggttgaaaaa tggcaaagaa ttcaaacctg accacagaat tggaggctac 1560
aaggtccgtt atgccacctg gagcatcata atggactctg tggtgccctc tgacaagggc 1620
aactacacct gcattgtgga gaatgagtac ggcagcatca accacacata ccagctggat 1680
gtcgtggagc ggtcccctca ccggcccatc ctgcaagcag ggttgcccgc caacaaaaca 1740
gtggccctgg gtagcaacgt ggagttcatg tgtaaggtgt acagtgaccc gcagccgcac 1800
atccagtggc taaagcacat cgaggtgaat gggagcaaga ttggcccaga caacctgcct 1860
tatgtccaga tcttgaagac tgctggagtt aataccaccg acaaagagat ggaggtgctt 1920
cacttaagaa atgtctcctt tgaggacgca ggggagtata cgtgcttggc gggtaactct 1980
atcggactct cccatcactc tgcatggttg accgttctgg aagccctgga agagaggccg 2040
gcagtgatga cctcgcccct gtacctggag atcatcatct attgcacagg ggccttcctc 2100
atctcctgca tggtggggtc ggtcatcgtc tacaagatga agagtggtac caagaagagt 2160
gacttccaca gccagatggc tgtgcacaag ctggccaaga gcatccctct gcgcagacag 2220
gtaacagtgt ctgctgactc cagtgcatcc atgaactctg gggttcttct ggttcggcca 2280
tcacggctct cctccagtgg gactcccatg ctagcagggg tctctgagta tgagcttccc 2340
gaagaccctc gctgggagct gcctcgggac agactggtct taggcaaacc cctgggagag 2400
ggctgctttg ggcaggtggt gttggcagag gctatcgggc tggacaagga caaacccaac 2460
cgtgtgacca aagtggctgt gaagatgttg aagtcggacg caacagagaa agacttgtca 2520
gacctgatct cagaaatgga gatgatgaag atgatcggga agcataagaa tatcatcaac 2580
ctgctggggg cctgcacgca ggatggtccc ttgtatgtca tcgtggagta tgcctccaag 2640
ggcaacctgc gggagtacct gcaggcccgg aggcccccag ggctggaata ctgctacaac 2700
cccagccaca acccagagga gcagctctcc tccaaggacc tggtgtcctg cgcctaccag 2760
gtggcccgag gcatggagta tctggcctcc aagaagtgca tacaccgaga cctggcagcc 2820
aggaatgtcc tggtgacaga ggacaatgtg atgaagatag cagactttgg cctcgcacgg 2880
gacattcacc acatcgacta ctataaaaag acaaccaacg gccgactgcc tgtgaagtgg 2940
atggcacccg aggcattatt tgaccggatc tacacccacc agagtgatgt gtggtctttc 3000
ggggtgctcc tgtgggagat cttcactctg ggcggctccc cataccccgg tgtgcctgtg 3060
gaggaacttt tcaagctgct gaaggagggt caccgcatgg acaagcccag taactgcacc 3120
aacgagctgt acatgatgat gcgggactgc tggcatgcag tgccctcaca gagacccacc 3180
ttcaagcagc tggtggaaga cctggaccgc atcgtggcct tgacctccaa ccaggagtac 3240
ctggacctgt ccatgcccct ggaccagtac tcccccagct ttcccgacac ccggagctct 3300
acgtgctcct caggggagga ttccgtcttc tctcatgagc cgctgcccga ggagccctgc 3360
ctgccccgac acccagccca gcttgccaat ggcggactca aacgccgctg actgccaccc 3420
acacgccctc cccagactcc accgtcagct gtaaccctca cccacagccc ctgctgggcc 3480
caccacctgt ccgtccctgt cccctttcct gctggcagga gccggctgcc taccaggggc 3540
cttcctgtgt ggcctgcctt caccccactc agctcacctc tccctccacc tcctctccac 3600
ctgctggtga gaggtgcaaa gaggcagatc tttgctgcca gccacttcat cccctcccag 3660
atgttggacc aacacccctc cctgccacca ggcactgcct ggagggcagg gagtgggagc 3720
caatgaacag gcatgcaagt gagagcttcc tgagctttct cctgtcggtt tggtctgttt 3780
tgccttcacc cataagcccc tcgcactctg gtggcaggtg ccttgtcctc agggctacag 3840
cagtagggag gtcagtgctt cgtgcctcga ttgaaggtga cctctgcccc agataggtgg 3900
tgccagtggc ttattaattc cgatactagt ttgctttgct gaccaaatgc ctggtaccag 3960
aggatggtga ggcgaaggcc aggttggggg cagtgttgtg gccctggggc ccagccccaa 4020
actgggggct ctgtatatag ctatgaagaa aacacaaagt gtataaatct gagtatatat 4080
ttacatgtct ttttaaaagg gtcgttacca gagatttacc catcgggtaa gatgctcctg 4140
gtggctggga ggcatcagtt gctatatatt aaaaacaaaa aagaaaaaaa aggaaaatgt 4200
ttttaaaaag gtcatatatt ttttgctact tttgctgttt tattttttta aattatgttc 4260
taaacctatt ttcagtttag gtccctcaat aaaaattgct gctgcttcat ttatctatgg 4320
gctgtatgaa aagggtggga atgtccactg gaaagaaggg acacccacgg gccctggggc 4380
taggtctgtc ccgagggcac cgcatgctcc cggcgcaggt tccttgtaac ctcttcttcc 4440
taggtcctgc acccagacct cacgacgcac ctcctgcctc tccgctgctt ttggaaagtc 4500
agaaaaagaa gatgtctgct tcgagggcag gaaccccatc catgcagtag aggcgctggg 4560
cagagagtca aggcccagca gccatcgacc atggatggtt tcctccaagg aaaccggtgg 4620
ggttgggctg gggagggggc acctacctag gaatagccac ggggtagagc tacagtgatt 4680
aagaggaaag caagggcgcg gttgctcacg cctgtaatcc cagcactttg ggacaccgag 4740
gtgggcagat cacttcaggt caggagtttg agaccagcct ggccaactta gtgaaacccc 4800
atctctacta aaaatgcaaa aattatccag gcatggtggc acacgcctgt aatcccagct 4860
ccacaggagg ctgaggcaga atcccttgaa gctgggaggc ggaggttgca gtgagccgag 4920
attgcgccat tgcactccag cctgggcaac agagaaaaca aaaaggaaaa caaatgatga 4980
aggtctgcag aaactgaaac ccagacatgt gtctgccccc tctatgtggg catggttttg 5040
ccagtgcttc taagtgcagg agaacatgtc acctgaggct agttttgcat tcaggtccct 5100
ggcttcgttt cttgttggta tgcctcccca gatcgtcctt cctgtatcca tgtgaccaga 5160
ctgtatttgt tgggactgtc gcagatcttg gcttcttaca gttcttcctg tccaaactcc 5220
atcctgtccc tcaggaacgg ggggaaaatt ctccgaatgt ttttggtttt ttggctgctt 5280
ggaatttact tctgccacct gctggtcatc actgtcctca ctaagtggat tctggctccc 5340
ccgtacctca tggctcaaac taccactcct cagtcgctat attaaagctt atattttgct 5400
ggattactgc taaatacaaa agaaagttca atatgttttc atttctgtag ggaaaatggg 5460
attgctgctt taaatttctg agctagggat tttttggcag ctgcagtgtt ggcgactatt 5520
gtaaaattct ctttgtttct ctctgtaaat agcacctgct aacattacaa tttgtattta 5580
tgtttaaaga aggcatcatt tggtgaacag aactaggaaa tgaattttta gctcttaaaa 5640
gcatttgctt tgagaccgca caggagtgtc tttccttgta aaacagtgat gataatttct 5700
gccttggccc taccttgaag caatgttgtg tgaagggatg aagaatctaa aagtcttcat 5760
aagtccttgg gagaggtgct agaaaaatat aaggcactat cataattaca gtgatgtcct 5820
tgctgttact actcaaatca cccacaaatt tccccaaaga ctgcgctagc tgtcaaataa 5880
aagacagtga aattgacctg aaaaaaaaaa aaaaaaa 5917
<210> 109
<211> 57697
<212> DNA
<213> Homo sapiens
<400> 109
agatgcaggg gcgcaaacgc caaaggagac caggctgtag gaagagaagg gcagagcgcc 60
ggacagctcg gcccgctccc cgtcctttgg ggccgcggct ggggaactac aaggcccagc 120
aggcagctgc agggggcgga ggcggaggag ggaccagcgc gggtgggagt gagagagcga 180
gccctcgcgc cccgccggcg catagcgctc ggagcgctct tgcggccaca ggcgcggcgt 240
cctcggcggc gggcggcagc tagcgggagc cgggacgccg gtgcagccgc agcgcgcgga 300
ggaacccggg tgtgccggga gctgggcggc cacgtccgga cgggaccgag acccctcgta 360
gcgcattgcg gcgacctcgc cttccccggc cgcgagcgcg ccgctgcttg aaaagccgcg 420
gaacccaagg acttttctcc ggtccgagct cggggcgccc cgcagggcgc acggtacccg 480
tgctgcagtc gggcacgccg cggcgccggg gcctccgcag ggcgatggag cccggtctgc 540
aaggaaagtg aggcgccgcc gctgcgttct ggaggagggg ggcacaaggt ctggagaccc 600
cgggtggcgg acgggagccc tccccccgcc ccgcctccgg ggcaccagct ccggctccat 660
tgttcccgcc cgggctggag gcgccgagca ccgagcgccg ccgggagtcg agcgccggcc 720
gcggagctct tgcgaccccg ccaggacccg aacagagccc gggggcggcg ggccggagcc 780
ggggacgcgg gcacacgccc gctcgcacaa gccacggcgg actctcccga ggcggaacct 840
ccacgccgag cgaggtaaga gccgcggcgc ccccggatct ggggcgggct tggcgtcccg 900
agcggccccc ggcgccggag cctcccggct gcgcgctttg cccgccgcag cccagccggg 960
gccggcgcct ccctccgctc gccgcccgcc cctttcacct cctggctccc tcccgggcga 1020
tccgcgcccc ttgggtctcc cctcccttcc ctccgtccgc gtctcctgcg ccccctccct 1080
gcgctcgtcc cgccgctctt cccgccgccc aacttttcct ccaactcgcg ctcgggagct 1140
ggcgaggcgg cggcggctcc tcagtgagtc ccgggaggga caggcccggg gcgaaggcgg 1200
cgaggcccgc ggtttcctgg actggggagg agggcgggag tgggcggcga ggtgggatgc 1260
gttgtgtgtg ttatgtgtgt gtgttgcatt ccactccatg tctttttggt ccccttttgg 1320
ggattcaccc ccaattcagc aggtagcttt gggctcaacg ctaaaaatcc ggggcattcc 1380
taagtccttt tccacccccg ggaaagcctg gggtgcgggt tggggtcgga tggggtggga 1440
gatgaactgc ggaggacgtg gagggctagg ttagcttctc ttggaatagg ttttaaggag 1500
gtgtcgtcac caaatggctg aatctgcttg agctgagagc gaaaaacgac tcccctttcc 1560
agaaggggtg atcttatgac ttggacggtc tctgaaaggg tcggaagttt ggggaacggg 1620
aggacaaccc acggtcgtta agccgaggtg tgggatgggg gcggaaggac cgttcggtcc 1680
caatctggtt cctagaggtg ggggaaggga tgagggtttt tgtccggtgt ggttcactcg 1740
gcagcgatgc gtatgcttct ctggcccaga cccctctgca cctcgcttcc cctaccgtta 1800
tgtttggggt tgggagaaaa gtgaggctac gacccatgtt tgcggaggaa ttttatggac 1860
cttgtagatg ggggttcata tagaacacac accccctatg aggcagccag acactttttt 1920
ggtggtggtg gggggggggt ggggtgtgaa gcctgtttct tgttctgagc ccagaagcta 1980
tcaacccttt tgaaaaacat taccacggtg cctttctccc ccagcactcc cccaccccca 2040
atttccagat gtagcagccg catctggttc cgtttcaccc cacacgggta caccgcagcc 2100
gcattattaa cttccctctt cctcccctcc ccctccccca aattaaaact cagattcttc 2160
agcctgtctt gaccacctcc ctccttaaca tttctggaga cttggagatg cggcgttgag 2220
attcggggga gaaaagaaag ttcccttgga tcccgagtta tttaagatct caccaagtta 2280
ttcgccgccg ctggtgggtg gcggcggtcc gggtgctttc tggattgcgc agtaaagagg 2340
catcttggga gatggggcca aggttttagg gggtgccact cgcgaacggt tcatccgcta 2400
gactaggggg gctctttggc tgtgcgtctg gccagaactg gccttgacga tggaagtttc 2460
tggaaccaaa gcgttgcttt ctctcccttg tgttatagct ggagctgcgg gagcgcctgc 2520
cctgcccgga gcccgcggtc ccctctcggc tgccccgcgg tggcgtcacg cgcccctccc 2580
ggagcaagcc cggtgcgcag ggccgggggc gtgggcggct gctgccagag gcgctctctg 2640
tgtgttttta aggactgatt tgggccgcat cccccggaaa ctaaagtggg gtgttttacc 2700
gtttaaataa cggctacagg tttgaaagcg gggttggatt ttcgagttgt gtttggtaat 2760
agtctttgag gcaggaaagc gccttgtggt ccaaagttgc cgggagggtg gggagagtcg 2820
gtgtcttacc cgcttctttc cagcctcttt caaattgaaa acacttctct ggtttccttc 2880
tttgggcggt agttttggag gctgtaatga aatcgcactt tctctagacg tggtaattaa 2940
ggtgactgtt tcctccgcag atgtgcccta ccctttgcac ctccggacca gcgctttttt 3000
tggaatacta tctagccttg agactgttta gcagaaagtg gccattttcc tcccttggcc 3060
cgggctcccg gtttcctccc tgaggcttgt ttaaaagcga agtagcaggg ccccgtggga 3120
cgcgccttgg tctgggtaat cacccccacg cccgggtcat ccaccttcct ctcggtgacc 3180
gaggttcagc agcctctgct attgccggcc gtctttgccg atggcctgcc tccctaatga 3240
cttgtttaca tatcctaccc ccagtgggtt aggagaagct ccggggctgc cccgaccctc 3300
cgagtgcagg gtgtttgggg accgggaggc tgctggggcc tgactccagc tgggagggtt 3360
atgaactgca tcagtgacga gctgcttgaa atatctgttg catttactct tagtcatagc 3420
tgagtgtcag ctttttaatg aggttcatcc agattgagag ccacttggac tgcgtacttc 3480
actgcctgct tttccaaaca tgcctgcaga aatgctcatt ttcgaggtat ttttcccaat 3540
gggaattcag gccagagtgg gcaccacttg aacaatctta gggtgcttct tttccttggc 3600
ctctggccat ggagggtgtt agacagttcc attaggtggc cctttgatag caagggaagc 3660
aaaggctcag gaagaaatgg agaagcgtcc cccactccct aggggcagag gattagatac 3720
atcggtgcat ccctcaggct gggctagctt tattcctggt ggactccaga gggcaagaaa 3780
attgaattga acactgggta ggcagattca agccttagag accaaggaaa atccatgggt 3840
tttgctttta gtggtgtgct ctttgttttc agtattgacc tgaaacaaga ctcctaaaat 3900
gagagatttg ctggtatgaa cttgggggtt tagcagccgg cttctacaaa ggcttttttc 3960
ttgccttcgt ttctaaagtg tctttcgtca aaatggctgt tagttataga acatcctagc 4020
aaagtttgag cctgttgctg ctggaggaaa aggagttaga attgattcaa atgtcttatt 4080
ctgaaagggc ctcacatcac ttgatagttt aatttcctcc tgggaaattt gtgtcttaca 4140
tttgtcttcc ccagagcttt gtaaaaggcc tgaacgcacc agggactagt gggagcccag 4200
atgcagagct ttagagaaga ttctggtgtt tccagagagg atgaaatgtc agacttgggc 4260
taggatattt gtttttcctc ctaaggttgc atctacttta aacagaaatt ctctcctcgc 4320
caccatttat ctctcccctg caatgaaaga aaccatgttt agggccctct cccccattta 4380
atagccctca catggatgaa ctatcccaag aatttggtgg ggttccactc atagtacatc 4440
ctgtcttcaa gagcaaggtt ttctagatta tgtgcagcag ttcgtgtttc acttgttgct 4500
tttttttttt tttttttttt ttgagatagt ctcgctctgt cgcccaggct ggagtgctgt 4560
ggcgctatct caggtcactg caacctccgc cttccggttg aagcgattct cctgccccag 4620
cctccctagt agctgggatt gcaagcatgc gccaccatgt ccggctaatt ttttgtgttt 4680
ttaatagaga tggtgtttca ccatgttggc caggctgggc ttgaactcct gacctcaagc 4740
aatccgctgg cctcggcctc ccaaaatgct gggattacag gtgtgagcca ttgtgcctga 4800
ccacttattg ctaatttttt atatgtctct tacttccaag gacatttaga cacttttttt 4860
ttttaaagag actcaaaaaa ttagcatttc cattggacca actaaaattt agcaagctga 4920
gctgagtaac tttctccata tgtttattaa gtacttgccc cctgccctct caacatgtga 4980
gtagagaatg gtcactttgg ggaagaaata agtcttattc tcatctgaag ggattaatgt 5040
tttggtgtta cttcctcaat tctgaagaac caagttgtcc agaaattttc tcagggttct 5100
ttggactaga gtttggctgg ttaacaaggg gtactaccta attgcttttc tctgatattc 5160
tcagcctctt tttctggagg agtatctctg tcagtttctt ttcatcagcc cttttttttc 5220
cttcattcac ttactcattc atccagttaa caaacatgtt ggcatctcct gtgtacatgc 5280
taggtgccga gggtgttagc aaaggttagg gaggcacaga ccctgttctg aaggagcctg 5340
cagtttcgtg gggagagaag agaatgaaga acataaataa caatcatata atatgaccta 5400
agtgctatgt gagaggggct agtaatgtgg tttgcaaatt tggaggaatg aaattctcca 5460
gctagaaggc ccaagaaagt cttatggaag aaacagcttc ttaaggtggg gttcagagaa 5520
aagggaaggg ctggcctgtt gcagaacaag gaatggcatg aagaaagtct tgcacagagg 5580
catggatgtt gcttcgagct gtggcgccct atagaaatag aacatgagca gctggtcaca 5640
gtggctcatg cctgtaatcc cagcactttg ggaggccaag gcaggcggat tgcttgagcc 5700
catgagatgg agatgagcct ggacaacatg gtgagaccct gtgtctacca aaaaatacac 5760
aaattagatg agtatgctcg tgcttactgg tagtcccggc tattcaggag gctgaggtgg 5820
gaggatcact tgagcctagg aggcagaggc tgcaataagc tgtgattgca ccactgcatt 5880
ccagcctggg ggacagagga agaccctgtt taaaaaaaaa aaaaaaaaaa aagccaggca 5940
cagtggctca tgcctgtaat cccagccctt tgggaggcca aggcaggtgg atcacctgag 6000
gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ctatttctac taaaaataaa 6060
aaaattagcc gggcttggtg gctcatgtct gtaatcccag ctacttggga ggcaggagaa 6120
tcgtttgaac ccgggaggcg gtggttgagc caagattgcg ccactgcaac tccagcctga 6180
gtgacagagc aagactccat ctcaaagaaa aaaagaaagg aagaaagaaa tataacatta 6240
taacatgagt tatgtatatg ttcagatttt ctagaagcca cattggaaat taagttaaaa 6300
gaaagaaata ggtaaaaaaa attttttttt ttgagacgga gtctcacttt gttgccaggc 6360
tggagtgcag tggcgcaatc tcggctcact gcaacctctg cctcccgggt tcaagcaatt 6420
ctcctgcctc agcctcctga gtagctggga ctacaggcgc gcgccactgc acgcagctaa 6480
tttttgtact tttagtagag acggggtttc accatgttgg ccaggatggt gtcgacctct 6540
tgacctcgtg atttgcccac ctcagcctcc caaagtgctg ggattacagg cgtgagccac 6600
cgcgcctggc caatatttgt tttttaatta acttgtttgt ttagatttta tttaatgtaa 6660
ctatatttcc aaaatattat catttgaaca tgtaatcaat atagaaatta ttgatgagat 6720
actttacatt tttttcataa caagttttta agatgcggtg tatacttttt acttatagca 6780
tatccgttag caccagccac atttcaagtg tgcagtggcc actgtgtggg ccacaggtct 6840
agaatataag acatgaagat ggagagtgag aaatgccttt ggaaaggttg gaagttcctg 6900
tccttctgct gccaattacc aaatctcctg agagtgctat taaggagtga ctcaaagcac 6960
tacacaaaga gaattataaa tatcttaata ttatatctga aatccaaatg cataattctt 7020
tacatttggt tggtacttta gagaggagag aatgggcaca gtcacccaca ccacccattt 7080
gagcctcata atcacctgtg atgtggcttc ctctaggtgg gaaaccgagg cttagaacgg 7140
ttaagtgact atcccagggt ggcaagatca taagtggaag ggtgtgaatt catactgtct 7200
ccagcggaca agaataaaaa gacccaggct gggtgtggtg gctcatgcct gtaatcccag 7260
cactttggga ggccactgta ggtggatctc ctgagcccag gagttcatta ccagcatggg 7320
caacatggtg agaccccatt tttattaaat atacagaaaa ttagcccagc ttctcgggag 7380
gctgaggtgg gaggatcact tgagtctggg ggatggaggt tgtagtgagt tgagatcgtg 7440
ccactgcact ctagcttggg tgacagagca acactctgtc tcagaaagaa taaaaagatt 7500
tggccatgaa ttcgtcagct agttttcctt acataatttt tggacaagga gatctgacat 7560
tcataggttt ttctcttaga agtgggagag cttcaaggtc acgtggtccg tccagcccct 7620
gctatctcac cagacactgt ccaccctgta tgttggatca gtactccagt gagaagacag 7680
caggcacttt cacccatgca gcccattcag tcttcataac cacctgtgat ggaggcaagg 7740
caagtatttc agccccctct gatgagtggg aaactgagat gtgccccctc tctgctcccc 7800
accgaggacc tctgcatgca ggcatgaatc ccaggagcct agctgatatt ggagagacgg 7860
ggcgggggga accagctgca gggtcttgga ggaagctgct gtgtacacct gcaaggctgc 7920
aggttacatc tatctgtcaa gcagtgaagg aaggaagttg tttctaaggg attggaaaaa 7980
ttcattaatt agtagaatga gaaactgagg tgaagcagga ggtggcaggg tcccagacag 8040
catgttggac tagtggcctg tgtcactgtg ttttttgcag gcgggtggca tggggtgtat 8100
gctgacttct tattccagga gttggtgcca ggaggccagg ttttcttaac atccttgttt 8160
tacagatgtc aaacttgagg gccagagggg taggagagga agagactttt tgtacctttt 8220
ttgggaaaga acaagaggga agctggcaga tgaatttgaa gtgcattgac cagggagctg 8280
agagagggcg gtctgcagcc agcccacacc tgggaggagg cggcaggctt ttctggggac 8340
agagtggcca agtcgaagca agcttaacca tctcaacatg acaccactct ttcccattgg 8400
aacctgagaa cttgttcagt attctgacac ttagcaaggg acctgggttt tcttggtcag 8460
gtgtgcgttt ctgggtgaca ggcctgcatc aggtgtattt tcgggatgta gtaagttgtg 8520
gaatatgggt ttaggggcat cctctggcaa gcactgcttc tatcccagct ctgggaatgt 8580
gccccatgca gtgtcctaga tggcccatct gtggtctgct tccaagggtc tttcttttag 8640
ttagttagtt ttgagacaga gtctcactcc gtcacccagg ctggagtgca gtgatgcaat 8700
ctcggctcac tgcaacctcc acctcccaaa ttcaagcaat tctcatgcgt tagcctcctg 8760
agtagctggg attacaggcg tgcaccacca cacccagcta atttttgtat ttttagtaga 8820
cgaggaattt caccatgttg gccagtctgg tctcaactcc ccacctcagg tgatactccc 8880
gcctcagcct cccaaagtcc cgggattgta ggtatgagcc aacatgccct ggcacaaggg 8940
tctatctttg accaatggaa ctgcaaatca agcctctttt gttaccagag ttaccttgga 9000
tttaccctta tctacttggt ttggataaat tgagtttgca tcagatggag tcaggcttga 9060
tcaatccctt atttacttcc tcccaccctg ttctctaata tccaaaaacc ttgaggcact 9120
attacatgct agctacattt ccttgagtaa agtacttaac ctctttgagc ctcagtttct 9180
ccattgcata aaaggaataa taaaacttat cccccataag tttatagtga ggaatgaatt 9240
aattcctcac tatagttcta aattaattct acttagggca tccttggtac atagtgggtg 9300
ttcagtattc atttcatttt ctcttttctg attcctttcg taaaagtaga aaaatgaaag 9360
agaaatgttg acttctcttt tgatttgaaa tcattaaaac attttagtaa gccttgggag 9420
ggagctagtg gtgtggcatg tgtatcccgc tggccaagca catgtgaacg aagccaagaa 9480
tccaggggct tttctgccag ccagcactga ctcacttgcg aggggccctg cctggctcgg 9540
gggaggcagg gctgaagtac cacattaggg catgttccgg ggaagtagat tctctgaata 9600
acttggatgg ctccctggag catttaggac agaagccacc tggaaaatag agatggtcac 9660
ccccacgtag ccttgacagt gcccagaaag tcttgtcact tggtaaatgt taacagctat 9720
gatccgttct ttaagaccct ggggagtttt aagttttacc ccaccagacc tgagaagggt 9780
aaagggctgc agattctgtt cttttaactg gggccagtgt gagccatctt tgactcagtg 9840
cttgcaatag accttgattc tgcagtggga cctcccaggc ccccttgccc cccgcaactt 9900
ctggactcat atccgtcaga catcacttgt caccttccag catcagggag aactggatcc 9960
ctcctggctc cacactctta ggctctttgt aagtagctgg tgagggtttt cttctctctg 10020
caagggaggc tggtagaact atggatgtga ttcgtacaat tttagagaca aaaagaaagt 10080
acccaggagg tcatttattt cagctgcttc attgcatagg tcggggagtt gagcatggag 10140
tccagcagct actaactagt tatctctgta cctggcttcc atttactggt ccttagcttg 10200
ttccgtgatt cttcattgcc ccttatttct caccagaggg actggttggc cctagatgga 10260
gtggtctttt taaaattttt tttttaaatt ttttgagaca gagtctcact ctgtcaccta 10320
ggctgtagtg cagtgctgcg atctcggctc actgcaacct ccgcctcctg agttcaagca 10380
attctcctgt ctcagcctcc tgagtagctg ggattacagg tgtgtaccac tatgcccagc 10440
taatttttgt atttttagta gagatgggat ttcaccatat tggccaggtt ggtcttgaac 10500
tcctgacctc aaatgatctg cccaccttag cctcccgaag tgctgggatt gcaggtgtga 10560
gccaccgcac ctggcctggg cagagtgaag tcttatgctg gggagccatc agcatgctca 10620
aacctcctgc aattgtagca cactttgtaa aactgtttcc cacaaaaggg cagaactatt 10680
tgggactttc atgagaccat tcactttgta gcacatacta ctttgaagtt tataccttgg 10740
aaaacctcat gatggtattc ccaggcttgc acgtaatctg cactcaaaac atagctgtag 10800
aattgaacta aagcatccct ctgtccaatt aagacctata acctctcttt ttgagacaga 10860
atctcgctct gtcacccagg ttggagtgca gtggtgcaat ctcagctcac tgcatccttc 10920
gcctcctgga ttcaagcgat tctcttgcct tagcctccga agtaactggg actacaggtg 10980
cgcgccacca cgcctgggta atttttgtat ttttagtaga gacggggttt cgccatggcc 11040
aggctggtct caaactcctg gcctcaagtg atcctcccgc ctcagcctcc caaagtgctg 11100
ggattacagg gtgcaccacc acacccagcc aggacctatg atctaattca ttgttggggt 11160
agcttcacaa ttttcttctg gacgccttag taagtccaca ctttaagcag ccaccacatg 11220
gcatacttta ccttctgttt ttcctttccc ctcccctacc tagaccctcc taacttttgg 11280
ggtttttttc ctttcctcag ggtcagtttg aaaaggagga tcgagctcac tgtggagtat 11340
ccatggagat gtggagcctt gtcaccaacc tctaactgca gaactgggat gtggagctgg 11400
aagtgcctcc tcttctgggc tgtgctggtc acagccacac tctgcaccgc taggccgtcc 11460
ccgaccttgc ctgaacaagg taaggtgctg gctgggggca gcctggactc ctgggccttg 11520
ggaacaggat gggctgggag ggaggtgata tggttgcagg tgatgtggtc aacagggaag 11580
gctccttccc aagtggagca aagaactccc ttcctgtagg agaaactctc aagatacctg 11640
ggttggttct ggtctggtta taaacataac tgacttcatc agaggttggg gtcatgaagg 11700
ctggtgacat ccatttacct gagatgacat gtttgtgggg ggtaatttat gcttttctct 11760
ttctgaggaa agaatatctg atgaggaccc tagtgtcaca ctttaacata ggtgatgtat 11820
aaaatgcagc tggtggtgca atggggagag aatgacctta gaatttgcgt gtagaacttg 11880
ggtcagacta caggggatgt tgtaggaggt gagagcttgc taaagacctc tgacttccag 11940
aaaattgttt caaggccaca tcttcgccag gcatagtggg tcacacatgt aacctcagca 12000
ctctgggagg ctaaggcaag aggatcactt gaggccagga gttcaagatc agcctaggca 12060
atatagcgag accccatctc tacaaaaaaa aaggaaatta actgggtgtg atggtgcacg 12120
ctgctagtcc cagctacttg ctactcagga ggctgagaca ggaagattgc atgatcctaa 12180
gagttgaggc tgcagtgaat tatgattgca ctactgcgct ccagcctggg tgaaaaaaag 12240
gcacatcttc tataagggtc agcagtcatg gcttcacgcc tgcattttcc tatccttaac 12300
tgtgtctcac aggttctgtt tgggggcctg ccaagcgatt tgctttggat aggtactgtt 12360
tgaggggttt tgaagtgatt gagacccagg aagcataaag gggcatggag acctatggcg 12420
tgttggaaat tcagagccat catcggtaac aggaaggact taccccacca ttcttgggat 12480
ctgtgtgagc tgtggaaagg cctcttggga gattataggt acagaatacc ggtggctttc 12540
gcgggacttt gaaaactaat gtatgagcat ttctgctgcc agaggatagt gtggttcgtg 12600
actcagtggc tggtcacaca gagaaggttg acacacagtg ggtgaaaggt tggaggtgcg 12660
cgtgatgggg tggctgtgtg caaaaggctg ccactcagct ggtcagggac tcgtttgaat 12720
gatgagtgat gggtgagaat atgtgtcctc tggatggagt tggggatgaa cagggaaagt 12780
tgtgtgagac tttatagaag gtgcagtggc tagagcaggc atattcatgt tgctgtcagt 12840
aacagaaccg aaggcaaggt ctgagctgga gcacggtggg gacccaaagt gggagagact 12900
gtgtctgccc acagggagtt tatggtcagg agggatgggc aagtacaggg ataagtaaca 12960
caagacagac tgtgtttaaa ccacccagtg aagttacaac cagaggtggt gggaatgcag 13020
aggaagaggg gagcagagag cacctgagat gggcttgagt tcagaagggg aaaaatgaag 13080
ggccctccag gttgaacagc atgagtgttc agagacagca tgtatatggt ttatggagaa 13140
cggtttgcct ggtgagtagg tagctctggg aaacaacact tggaaaaatt ggattgagtt 13200
agcatatgga aggcttaatg ccctgctaag aaaactatac ttagggccgg gcacggtggc 13260
tcacgcctgt aatcccagca ctttgggagg ctgaggcggg tggatcacaa ggtcaggagt 13320
tcgagaccat cctgcctaac acggtgaaac cccatctcta ttaaaaatac aaaaaaatta 13380
gccgggcgta gtggcaggcg cctgtagtcc cagctactcc agctccagtc tccagctgag 13440
gcaggagaat ggcgtgaacc cgggaggcag agcatgcagt gagctgagat cgcgccactg 13500
cactccagcc tgggcaacag agtgagactc cgtctcaaaa aagaaaaaga aaactatact 13560
taggccaggc gtggattatg ctggtaatct caacattttg ggaagccgag gcaggaggat 13620
tgcttgagcc aagaagtttg agaccagcct gggcaacatg atgagaccct gtgtctacaa 13680
aaaatagaaa aattagccag gtgtggtggc acatgcttgt agtcccaact attagggagg 13740
ctgaggtggg aggatcactt gaacctggga ggtagaggtt gcagtgagcc atgatcacac 13800
cgcttcactt cagcctgggt gacagagtga aactctgtct aaaaaaaaaa aaaaaaaaaa 13860
agcaagaaaa gaaaactaga cttaaatggg tagatgctgg gaaacttgaa aagtttttag 13920
caagtagtga cactatcagc tttcagaaag ttaatttggc agctcagtgt ggatggctgg 13980
gaggaaagag tgaggtgcac ctgtgtttgc atcctgctct gccacttgat agctgcatta 14040
tttacttcaa caaactactc aaacaccata cgtcacagtt tgctcatctg taaaacaggg 14100
ataaataata aagggttaag tggggtaatc cagatgaagc acttccatgt aaggtgttaa 14160
tagttgctat tgctgccact gctgctgcca gaaggatgag gtcgcaggtt attttgagtg 14220
tctggctaga ggaagtgcag gtactgacca ggatggggac tgggagatga tagaggaagg 14280
aaaaagtagt aaagacacta cagcaatagc atctgtgggt ttaagtaggt tgggtgtcaa 14340
ctgtgggcaa ctggagactg agatgagagt gtaaagggag tgagtcagag tgggaggttt 14400
gaggggagtt tagatttgaa tccgccaatt gtagacagcg ataaaggagt ggaagagtag 14460
caaggagcta gttgaggttt gagaatgtga atttataatg gagcctaaag tactttcttt 14520
tttttgcagc ccaagaaggg agaagtggat ctcgggcctg gctgcttgtg agccagcccg 14580
acgggatgag tataaggaac tttagggcca gggtgggggt gctagtagag gagggggctt 14640
cacggaagct gctggggcag ggtggaggct ggaacctggg ggctgaagat cttgatgagg 14700
acaaagtacc ggccctgtga acagaagaaa gggagtaaga gaggtggatg gggctcttag 14760
gagccatgta cccaggaaga ctgacattaa atgaccattt tttaaaaatc aacttaattt 14820
tcaaaggcac attggctccc acctataatc ccagtactgt gggaggcaga ggcaggagga 14880
tcacttgagc ccaggagttt aagatcagct gggtttgttt gtttgttggt tggttggttt 14940
taagagacag agtttcactc tgttgcccag gctggaatgc agtggcatga tcttggctta 15000
ctgcaacctc tgcctcccag gttcaagcga ttctcctgcc tcagcctcct aagtagctgg 15060
aattacaggt gctcaccact atgcctggct aatttttata tttttagtag agatgggttt 15120
caccaggttg gccttgaact cctgacctca agtgatctgc ccacctcggc ttcccaaagt 15180
gctgggacta taggtgtgag ccaccacacc tggccaaacc aacttaattt aggtataaca 15240
gtttgggcta ttgtaataag actgctgtga accttcatgt gcaagcctgg gtgggcacac 15300
attttccttg gactgccctg gttttgattt tggctccaca ccttactgac tgttggctct 15360
tggggaagtt cctctttgtg cccttttata aaatatattg ataatgaatg tgtgctcata 15420
aggtcattgt gaatatcaaa taagcatgtc tgcagagctc ataggacatt gcctggtccg 15480
taggccatga gcagtcaatg gccgttgtgg gtccctttcc ctgggcctcc aggggagacg 15540
gcacatggcg aggagcatgt tgtttcatgg gacacagcaa cggaaagccc ctgcacttgg 15600
agaacaagcc ccaggtctct gtttggtgga gtaagccccc gtctcagtgt gagtgtggtg 15660
ctttcacata gcctgtctct catgagcttt gtgacagaac agagaactgc tgtgcccagg 15720
acattctaag gggagatctg gcttcatgct ttgtaagctg taaggaacct tgtaagtgta 15780
aagtatattg catagtcttg ggcctgctga ttattaaata ataatgctga tattttttaa 15840
ttaattaatt aatttatttg agacggagtc tcactctgtc gcgaggctgg agtgcagtgg 15900
cgtgatcttg gctcactgca acctccacct cctgggttca agcgattctt ctgcctcagc 15960
ctcccaagta gctgggatta caggcgcgtg ccaccacgcc cagctagttt ttttgtatat 16020
ttagtagaga cggggtttca ccatgttggc caggatggtc tcggtctcct gacctcatga 16080
tctgcccacc tcggcctccc aaagtgctgg gattacaggt gttagccacc atgcctggcc 16140
aatgctgctg ttgtcctaaa aaaaaaatca tagggcgagc acagtggctc acacctgtaa 16200
tcccagcact ataggaggcc gatgcaggag gattgcacga gcccgggagt tccagaccag 16260
cctgggcaac atagcaagac cccatctcta aaaattttaa aaattagctg ggtaacgtgg 16320
cacacatcgg cagtcctagc tattcaggag gctgagatgg gagaattgct tgagagttgc 16380
ttgagcccag gagttgaggc tacagtgagc tataatcaag ccactgcact ccagcctggg 16440
tgtcagaagg agaccctgtc tttaaaaaaa agaagaaaca cattataatc tatgtattaa 16500
gggctttgtc caaaaggtga gagcaaacca cctaaaaccc tgttcacact gagttttccc 16560
catttaaaag gccttgctgt gattttaagt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 16620
gtgtgtgtgt gtgtctgtgt gtctgtgtgt ctgtcgggag cccctcccca ctgagcgcag 16680
taccaacgcc cctcagtctg caagtgctcc tgagggattg gggagggcct ggagtttctg 16740
gctgtccttg gaaagttgat ttaataaggg ttccaggaaa accagcctcc ctcccctctc 16800
cctctccttc ccctcctttg gtttgggatc ttacagagcc tcagcttgtt tcagatcagg 16860
ctttgagagt ggtgagggag ttgtttggaa agactgaagc cggtttcaga tgataagccc 16920
caacattctg agcttgcaga gggtgcattt gtctgtcttt tgcaataagt caagtcttgg 16980
tgggcaaagc cagtgagtga gtacaacact gcttgcaagg ccactgctgg tagttggggt 17040
gggggtcctg cccccttttc agcagtactg tgggttaaac accccagtgc tcagaaaacc 17100
tgcagctcag aagtgattta atgggctgag ttttacagct cctcccaccc acccagattt 17160
gaaggagtct ggtggcttgt tagagggggg agaggttgca cttaatggaa aaaccacaca 17220
tttccattct ggcctcaagc cccctggatg ccctgtgtgc accacaaagc ggggctttgt 17280
ctctgtgttt tgcagaaacc tgcacctatg ggggagaggc tgtgcgtggt gccagagcca 17340
ttgcctagcc tcagatcata gggcccttgc aggtcctcca tccctgggcg tctccagctg 17400
cctttggccc aaaggggtgt gcgtttcagc ctggctgcag ggagagtctc aaataggtac 17460
tacaggtttg gtagtgggac accctctgtt ccactatcag acctgtagtc tagcatctac 17520
actggactgt ggtcctgtgt cccaaggctg ccttgggaca caggcaagac cctcccctac 17580
tcccacccca tctccagcat gatttcttat gatgaaaaga acttgtttgc ttctcattca 17640
acctggatgg taagaggagt ttcttcatcc cctgccagaa ggcgaatgga attccatgga 17700
gcaaaaggtg atgtcagatg accctcttga gaacaagggt ggaggattta ggcctctaga 17760
aatctgcaag gtgctaagct cataacaggt ttccccagag gatcagctct gtcccacttc 17820
ccctggagaa gtggctccag tgcctggaag gggtgtttgc aagtgttcag agctggacag 17880
ggaggaccca gccctcggcc tgtgagagaa tgtgaggacg ctcacgtggc cctcttgacc 17940
aagctggggc aagcgcagca aagccactcc gaggctgtgt tcttggctcc ggcttctgca 18000
ttgctacacc attagcttca ctgattttcc actctggctc tgccaggccc gctccctgaa 18060
gtcagggagg aggaatttct cagggaagaa caaatggctg tccagagatc ttgctgccag 18120
tgggggaagg gagggatccc aaacaaagac tctgtcaggg tttccatcac ctggttcctg 18180
tgactacctg gagtcgggtc agcaggaact ggagagacag catcagggat tctttgggag 18240
cctgtggccc cagcacggag gggtgtttgc tcctggccag gcagaagcag tgagtgatgg 18300
cttgtgtctg ggcggtgatg aatggccctg ggagaagtga gtcctgggga gtcattatcc 18360
gggagggcga ggtctggggt cagagagccc gaccagcagc tggccctatt ttcacaatgc 18420
ctcgttcctc cggggccact gggggctcca gctcaccctg tagacaccac ctttgcctct 18480
ttcttccttc cctgaggctt ggaaatgaga caactgtttc cctgttgacc ggggaagtcc 18540
agctgctctc attctcctgg gctcctgaac ggggcggccc aggccttcct cctgggcctg 18600
gctctttcac caacttgcag gcaggcaatc ccttctcccc acccaccata ctccccagcc 18660
ccactgcacc ctaaataatt aagctgaaag ctaactgccc tacctggatc tgaagggcct 18720
gggctaaatc ccaaactgtt tcctcctagg agaagcctgc tggagtctgg gccacttctg 18780
accttggggt ttgctctgac ttacagctgg tggcagccaa gtagcagggc caattgccct 18840
aacccctcct ccccggtagt gggcctgttg cctcttagca ttgccagtgt ggcaccaaga 18900
gacattgaac ttctaccctc agagttccct cccttctcct gtttcttggc tcacaacagt 18960
tcttgccttt ccacttgcca aacaggtatc tactgccttc atgtaaagca tttgtgccct 19020
gcaaactagg ggctgtgggg tgagggctcc gtgtagctgg tttcaggcac tgagaaagat 19080
ccaccctggc agagcttgaa actccacgcc ctctcctcgt tcacatgctg tggcgtggct 19140
gagcctcccg ggatgggttg tgtaaaaggt ggggtggggg ctgtgccatt tgtgttccca 19200
ggccctggac atggagacac agggagcctg aagtgggtga gagggtcaag gagttccgca 19260
aagagtagac ttagtggtta cgaggttggg cagagaaaga ggtcagaaac agcaacacgg 19320
aggtttctag gagttaacca acagtgaaca ttgaattcag agcttagccc ttcctcactt 19380
ttctctagga tcaaaaacta gcttctggct aatggtccat tcattgactg attttttttc 19440
actcattcat ttattcattc atctagtcaa gcaagtctct tcctttttcc gtaaatacaa 19500
tgtatacttt atacattgtt ttatcctagt cccttagctg gaaatatctg ttcctgtcct 19560
tttcttcctt ttcacttttt ataattcctg ctcaaatctt agtttaaggt ttagcttggg 19620
tttagattaa agcttaactt aagggccacc tcccttttga agccttcccc tatctccaaa 19680
ttaattaccc cattttttct ctttttcttt tttctgtgtt ttttttttct cctgagacct 19740
agtctcgctc tgttgcccag gctagagtgc agtggagtga tcatggctca ctgcagcctc 19800
gacctcctgg gatcaagcga tcctctggcc tcagcctcct aaagtgttag gattacaggc 19860
atgagccacc atgccctttt gagatgtagt ctcgcttagt catccaggct ggagtgcagt 19920
ggcgcgatct cggctcactg caacctctgc ctcccaggtg ctagcgattc ttctgcctca 19980
ccctcccgag aagctgggat tacaggcacc caccaccatg cccagctaat ttttgtattt 20040
tttgtagaga caggttttcg ccatgttggc cagtctggtc ttgagctcct gacttcaagt 20100
gatccacccg cctcagcctc ccaaagtgct gggattacag gcgtgagcca ccacacctgg 20160
cctcttttta actttcattc taacacttac tttactctgc ctcacattat gtggagtttt 20220
taatagatgt ctgtttactc cactagagca aagttctcta tagtcagcaa gtatatcttt 20280
atcactcttt taaaaacatt agtgtttagg ctgggcgcgg tggctcactc ctgtaatccc 20340
agcactggcc agcctggcga aaccctgtct ctactaaaaa tacaaaaatt ggccaggtgt 20400
ggtggcacgc acctataatc ccatctactc aggtggctga agcaggagaa tcacttgaac 20460
ccgcgaggcg gaagttgcag tgagccgaga tcgcaccact tcacttcagc ctgggcaaaa 20520
gagcgaaact ccgtctcaaa aaaaaaaaaa aaaaaattgg tgttttgtta gataatctgg 20580
gttcatcttt caaaattcag aaaatacaga cctgtaaaga ggaaaaggaa gactcctata 20640
attccatcat tcaaaagcaa tcactgttaa ctgaatttat tgttttagac ttttttcttg 20700
catttatgta aacctgactt ttcagaatta ggatttatac tgtatacgat gttttgtgac 20760
tgatatcagc atttagagcc atacagagaa tgtttttcat tatgcttaag aactacataa 20820
tgttccattg tgtgggtgta caaagttgat ccagttctct acatttgggc atttaggtta 20880
ttttcaatag tttgcattca atagaacata ttcttacaaa taaaatctgt ccatgtatcc 20940
aaggatagtt ccatttgttt taagttttga ttttatcact attacatcac tataccaaat 21000
atcccccaaa agattatacc agtaaatgtc ttttaaaata taataataaa taccagccgg 21060
gtgcagttgc tcacacctat aatcccagca ctttgggagg ccgaggcagg cagatcactt 21120
aaggtcagga gtttgagacc agccttggta acatggcaaa acccttctct actaaaaata 21180
caaaaattag ccggtcatga tggcggccac ctgtagtccc agctactcag gaggctgagg 21240
caggagaata gcttgaaccc aggaggtgga ggttgcagtg agctgagatt gcaccactgc 21300
actccatcct gggcgacaga gcaacgctct gtctcaaaag taataataat aaatatcatc 21360
tccacactct gcatgcttga cattttccca tttttacaat gattccatag gcataggttt 21420
tatgaccata atcagatgag taaactgagg tttgaggggt taagtaacct atcttaagtt 21480
tatatagtgg gtgaggggtg gaactaggat ttaaactcag gtggttctgc tatagtattt 21540
ttttcccatt gtattacact atttttctat atcaaattgg gtttccccac aaaatctagg 21600
tggaccaact tctgaatgta aacattgctg gctcagtccc ctttgtctca caggagtcag 21660
gcatcccctc cctttgtcag gggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 21720
gtgtgtgtgt gtgtgtttgc ttgcagtaat atctcctgtg gcattctgta gagaggttac 21780
acatcagtca caggtctgtg aactgcctta atgaacaagg ttccctagcc tagaataatc 21840
aatggaacaa aatccccatg gacgctgcca tttccactgt tgccaaagac ctacatggag 21900
aaggttccca aggtgtcaga tccgacacct gagttttctt tataggtcac agttagccta 21960
gaatgtgtgg tatgggtatt gcctggacgc ataaactaga ttgcttctaa tatggatgtg 22020
gtccaacaat ctctgatgaa tggaagtaaa catatcaaaa gcttcagagg ctgggacatt 22080
aacatttttt tgaggctact agtgtttttt ataaataatg aagaagggcc aggcgcagtg 22140
gctcacacct gtaatcccag cactttggga ggccgaggtg ggcagataga gtgagctcag 22200
aagacccgct tgggcaacat ggcataaacc ccatctctac aaaaaataca aaaaattacc 22260
tgggcgtggt ggtgggcgcc tgtaatccca gctactcggg aggctaaggt aggaggatca 22320
cctaggcctg gtgtggtggg tcacacctgt aatcctagca cttttggggg ccaaggtggg 22380
ctgattgcct gagctcagga gttcgagacc agcctgggca acacggtgaa accctgtttc 22440
tactaaaata caaaaaacta gccgggtgtg gtggcgggcg cctgtaatcc caagtactcg 22500
ggaggctgag gcgggagaat cgcttgaacc agggagtcag aggttgcaat gagccgagat 22560
tgtgccactg cactgcagcc tggctacata gcaagacttc ctctttaaaa aaaaaaaaaa 22620
aaaaaaaaag gtgggagagg gctgagtcag tttgccttgg aggcatgggg gaggagaagg 22680
atgtgaacag ggaagtgatc taagagcttc cctaggaagg aaggacaccc ttttcctgga 22740
atgctctcct gctctgccac agctttcagt caattatcac tgcctttaga atgcttatca 22800
gcactccagc ccttcagaag tgtccttctc ctcctctggt gtcaaactcc agagtttact 22860
tttggaatta aggtttattt tccttaggtt ttaggaagta gcttttgaac cttagaagag 22920
tcagtttcct ttactaacta ctgaatgaag ttaggcattc aaaacttggg tagtcatgat 22980
ttgaagtgtc acttgcggcc aggcacagtg gctcacctgt aatcccagca ttttgggagg 23040
ttgaggcggg cagatcacct gaagtcagga gttcaagccc agcctggcca acatagtgtc 23100
tctactaaaa atattaaaaa aaaaaaaaaa taaccgggcg tgatggcagg cgcctgtaat 23160
cccagctact ctggaggctg agacaggaga agcacttgaa tccaggaggc ggaggttgca 23220
gtgagccaag attgcaccat tgcactccag cctgggcaac agagtgagac tccgttcccc 23280
aaaaaatgaa atgtcaattt cattgagact gtatgaatgc ctgacatgca cttgaaagtg 23340
atgtttattt tataatttta gcccttcttc actaccccaa actcccagtg catttaaaaa 23400
atttattggc ctagccattc tcatggggta atatatcatg accatcaaaa gatgacacta 23460
aagtgaatcc tccatgtata gctgggcttt ctgccagcct tagattctgg agaagcaccc 23520
caggccaggg agaacgggtg aagaggagaa gcatttattg aaggtgctgg tagccggagc 23580
cctgagacca acacagaatc gttttttctg aaggacaact caaggacagt tgagggctct 23640
tcacttccct cacatcagag ggagctttgt gctcacgatg ggcacggaaa gggatgccag 23700
taagcgatgc ccctctatca tctcacaaga cccaggtgaa acaggacatt ggttagggct 23760
gggacagggt cagtcagcct tctcatttta cagtggagga agctgaggct tgagagggga 23820
ggtgacttgc ctgaggtcac acagtaagtg atcagctgtc atctgagtga tttcttcagg 23880
tactctctct ggctggaccc agccagtgac aactacctgt ggctcaagct gagtttggga 23940
ctaaatggtt ttacaaggac ctcaaagtat actctctctc ttctagtagg acatggggaa 24000
tactgacttt gctgagagta agggctcttt tcccaggatt gttctagatc cccagatcac 24060
tggaaccctg agcatagata ctaggcttta gcttcctggc taccacagag ccacacactc 24120
tcaggtagaa aaatccctaa actggctggg catggtggct catgccagta atcccagcac 24180
ttttggaggc ccaggcaggt ggatcacctg acgtcaggag ttcaagacca gcctggccaa 24240
catggtaaaa ccctgtctct acaaaaaaaa aaaaaaaatt tagccacgcg tggtggcaag 24300
tgcctatact cccagctgct tggggggctg aggtgggggg atcacttgag ccagggaggt 24360
ggaggctgca gtgagctgaa atcatggcac tgttctttag cctgggctac agaatgagac 24420
cctgtctcaa agaaaaaaaa aaaaaaaccc gaaccatgtt tttaatttct taaaactgag 24480
agtactaaat gctcaacgtt catgttgtgt gcataaaagt gagactgaag gatgaatgtg 24540
tggggtatgg atagatggga tgtgaatgaa gcagtctctg ggtccaagct ctcctggaaa 24600
ttcgtggaac agaccagtgg tcccagattt ttagatttca taggccagta aaatttccct 24660
ccagattttt ggaaccaaca aaggatcatc aacttttttg ccaagtaaga acgtttttaa 24720
taaactaatg ctgcctgcta ccattaccac ctgattcttt tttttttttt tttttttttt 24780
tttgagacag tttcattctt gttgcccagg ctggggtgca atggtgcgat ctcagctcac 24840
tgcaacctcc acctcctgag ttcacgcagt tctcctgcct cagcctcctg agtaggtggg 24900
attacaggca ttcgccacca cacctggctc attttgtatt tttagtagac acggggtttc 24960
tccatgttgg tcaggctggt ctcgaactcc tgacctcatg tgatccgccc acctcagctt 25020
cccaaagtgc tgggtttaca ggcgtgagcc accgagccca gcgccatcta attcttttgt 25080
tgtggtaaaa tatatgtaac ataaaattaa ccattttaac tatttttatt tttttaagtt 25140
aaattgatta tgtaatgttt ttgagacagg gtcacacttt gtcacccagg ctggagtgca 25200
gtgttgctat ctcagctcac tgcagcctcg acctcccggg ctcaagagat cctcccacct 25260
cagcctccca agtagctggg accacaggtg cacgctacca tgcctggcta attttgtttt 25320
tctttttttt ttttttttgt agagatgagg tctcactttg ttgctcaggc tgatctctaa 25380
cccctggact caaacaatcc tctcacctca gcctcccgaa gtattggagt taagagatgt 25440
gagccactgt gcccggccaa tttttaaatt tgtaattgat gcataatggt tatgtataat 25500
cgtcgggtac ggtatgatgt tttgatccac gcacacatta tgtaacgacc aaatcatggt 25560
aattgctgta ttgtatccat cactttaaat atttatcatt tctttgtggt gcattttcac 25620
caattttaag tgcacagttt tgtagcataa aatttattca cgctgtgtag ccatcaccac 25680
catccatttc accttccctg acaccttacc tgttcaacgc taactccccc ttctcccctc 25740
ttccagcccc ttggtaacca ctattctaca gcttttcatt ttcaaaggat gttttattgt 25800
ctttagtctc atcgtgtgaa accttaagag aatttcttta cggtggagaa aaagtaactt 25860
tatgaagccc attcctttct ctactctgga gaggctggtg acccagcccc accattgcag 25920
gaatgagacg ggattgcggg gatatggcag gcacttgggg tgctgagagt ccaggtgaac 25980
tgtgagctca agcacccatg tcgggcttgg gggaccagaa gacacatcct gaaacagctg 26040
aagcctctac taattcatca gcaagtttag ggagcggcaa cttttccctg cccagctgct 26100
ggcgtttcct tccccataca atttctgctg agtttggggg aggggaggtt gttcgagagg 26160
ccccagctgg gagaggtggg gggagggcga tacattcttt tccttaagga acctgaccga 26220
actttaaggt cagagctcag tggagagtgg gagctgcagg gttacctctt tgccgttgat 26280
tcatctctcc accctccccc actcttaatg atctttccat tacagaaccc agaccaggaa 26340
gtgcatgaca ggtcgcagct gcagacacat ggctgggagg cctgggctcc gggccagtgg 26400
tgggagagtc tgagctcccc tccagcagtg ggacccctgc acacacacac acacacacac 26460
acacacacac accactttaa caacttggtg gaagatgttc tttcttatgc actgtcacag 26520
gtgatgacga gttggacttt gctttgagtt taggatgtga tttatattat aataaaggca 26580
ggagaagaca ctccccctgc cccggtccaa cctgagtgtt tagatccccc caacttacag 26640
tccacctaag tggtccttac cagatcctgg gagctttcta ttatcgtgca gatgccccaa 26700
cttcttttcc caaaatagga cccacccaat atggccttag aagcttccca gggtatccgg 26760
ggcagttgct agtcacagtc ttaatgtctc cgaaatagta tgttttcctc tctatgtttc 26820
tattaaaatg tcagccccaa aacatgtttc tgggtggagg tctaggtgca acagcacagc 26880
ctttgcaaac acagatagac ttgggttcaa gtcataatag atgagttgag cctctcattt 26940
ttcagtcttc attggggatg gctctttcca tttgcaagtt gttcaggaaa tgttaattga 27000
ccctaaactg tgtcctaggg ggcagttgtc acacaggagt ttctgtcttc accaccagct 27060
gtgtccttgg cttccttccc tgaatctgcc aaggctggat tctggtgcta aatgtgaaat 27120
ggtgacacaa acttctagga actgtgagct tggacggccc tcctccatag ccgcagggca 27180
tctacctttg ctcttcttgg atgagtgaat gaacttccct ctttccagag caatgctttc 27240
ttcctgttta gataggaggg agagaagcaa agtgtattgg gaataggttg agcgaaagag 27300
tgtagtaaga gttttctgta cagctctgtc cttaatgtat cagtaaacaa tagggtgaga 27360
acttttgctg gggagagagg aaggagggaa atttcttttc agacaactct tgggtgcatt 27420
cctttgttaa tcacttaatt acagcccttc tcccagtgag gtagtgaact ccccattgtg 27480
agaggtaggg aggaggtggg ggacactggt gctgattgga gaaaggtggc aaaatcccta 27540
ggggaaaaaa gtacagattt gaaggaggca tcagatgaat ccgtgcatag aagcttgagc 27600
cccaaactca gttctcaggc tgcgttatcc tttacgacac ccagagtccc tctgtctttt 27660
aagatccaca cacaactctc caggccaata gctcttggcg cctgcgattc ccaagtggga 27720
ttctacacgt gtcttgctgc ccagctcggg gggatctgtt tttggggggt ctcggggcgg 27780
gtgcagggtc ctggctgtgg ctttggctag tgcaggcggc tcggcactaa attacagtga 27840
cgaggtggga cgcacaaaag gccgaaatct ttttttaata aaaacaaaac aaaactctgg 27900
gccccaagcc cctgggctgc tgaatggcca tggcttcctg tcaggattag ccgggctgcc 27960
tgggcctgtg tgctcggcct ttctcctcag gaaatacctt tagtaagccc cggtggggtc 28020
cccatggcaa cgcacggggg gacctgctgg cagaggccat tcagtctgcc attgtccccc 28080
ggcccctttg ttgtgagctt tattgccggc cctctggcaa acacagcagt ttgcaccgtt 28140
ttgtcaggct gaatgtggag tttttacatt ttaatgggct cttctggcag tggcccattt 28200
gcatgcaaaa tgtcccctct tactcttttc actttcttca atttaaaaaa aaaaaaaaag 28260
cccttctcca aatcccctgg gtcggggggc tggtggacgc cattggccct gggtgtcagg 28320
ccctgctaat tgatttggtg ctcccggctc tctttccaca catacctgtg ccccccattt 28380
ttgcagctct ccttctattt ggggactccg agagttgaga gaaacacatt tttggggctc 28440
tctccaccca aacccttgta ggatggcagc tgtgacccgg gatttcggtg agatgcttct 28500
gcactctggc cgggtcctgc cagccgaagg taagttttca gttccatttc aaagccaaaa 28560
tacgtaataa aaaaacctct gcagagggcc cccggagccc cgctgcgctg ttctgtgctc 28620
cttttaagtt gctttcaaag ccaccccgag ttcctccccc acccacaatt gccccctcat 28680
ttatctctgg ggagtttata ccaagactgt aaacattcct ggaccaccag tttcccccat 28740
gttgctgagg agtttagcct ttctctccta attttcttaa ctcagaaatc aaaaagatgg 28800
aatagggatg atagaaattg ctaccctgag acatcatgct catggaggat gcctggattt 28860
tgttgggggc cagttatcca agccctaagc cctttggagt gtagaacgta gagtaggtaa 28920
tacaaatacc tactgtcagc ccagcacccc agcaacatga gtaagtgcaa gacacaggca 28980
tgaacatttt cagctctagg gaaaggcaca ttcatgttgg ggagaggtgg agaatgcagt 29040
ttggccagtc tcagaagagt gagttttaag gcctaggaaa gtgatggaga tgattgcttg 29100
ttggagagag agaaggagaa aggcatttag gggaagaaaa ggaaaatgaa aggagcagtg 29160
aggatattgg ctccactggg gaggtggaac tggggtagtg gccgaaccag gggtgggaga 29220
ggacgtggtt gagaggctcc agaccagctg gggctgtcat ggagtgttgg gggtctggag 29280
cagtcaggac ttgaaagccg ggacccttgt gagccctgtg cagtcctgag gatgtggccc 29340
aagggggagg gcggaccagc tcttttgcct cgtgttctta atcttctcag tgggtcatca 29400
ggggtcatca gctgtaagct gtaatcaacg gtgaggggct cgagaagaga aggtgtcagg 29460
tgactgctgg ggattgagct gaggacagga gaggcagggt gctgtctcct gtggcccagg 29520
cagagcggca cagacctgga gtgggccacc cctcatcacc ccatgtgctg cgacagtgct 29580
ggctggactg aaccctggaa gagtacctgg acacagtgga ggggccagga cccagcagat 29640
gcagcctcta gagcttgtcc ctgttttgtg actttgggag ccatttttcc atgtttaaat 29700
gggaaggaac acaagtcacc tggtcacaag gaagcaggcc ctatgaaata ttaagtgcaa 29760
tgccaaaaca gggcattgtt actggtcttg agtctgccac aatcacaatg aacacctccc 29820
ccattttctc acctgccaca tttggacagc cgagcctgct ggactcgcag gggcaggaga 29880
gtgcatttta taattaaaag cactcaactg taaggtaatg attgatatga gctatgggct 29940
tgaggaaatg agggaaggag gggaggataa ggccaaagca accaacttca gaatctcacg 30000
ggaggaggta ggatgcaggg ggtgccatta gacagaatca aagggctgaa ccagaagggc 30060
ttcctcacct ggggaagtca agacactgtg aagattgagg ctgccttgca cagcggtaaa 30120
gctggactct ggatgtatga tgtatgtgga ttctggagaa ccaggctacc tgtgtttgaa 30180
tcccagctct gccacttaac aacctagctg ggccatcttg gactaatccc aaatctttct 30240
gtgccccagt ttccccctct gaagataata attccttttt tttttttttt ttgagacgga 30300
gtctgggtct gtcacccagg ctggagtgca gtggtgtgat ttcggttcac tgcaacctct 30360
gcctcctagg ttcaagtgat tctcctgcct cagcctcctc agtagctggg attacaggcg 30420
tgcatcacca cgcctggcta attttttgta tttttagtag aaatagggtt tcaccatgtt 30480
ggccaggctg gtctcaaact cctgatctca ggtgatccac ccacttcggc ctcccaaagt 30540
gctaggatta caggcattag ccactgcact gggcccgaag ataataattc taactcttaa 30600
atacttcaca agattctaag ttaacacatg ctgagaacta tgctggtatg tagtaagcct 30660
ccgcatccat aggatagaaa tcatagtagg atcaacctca taagtttcct atgaggatga 30720
aatgggaggg tctgtgttaa aagctttgtg cagcctatgg gatatagtga gcgtgctgga 30780
aatattggcc agtagtagta ttgctgttta ctcagatgtt tatggatccc tagataatat 30840
atgggaaggc acatggtaaa ttacaaagtg ctatgcaaat gtgttgttat tcttcactgg 30900
gttcctgtta agttgtgggg tttggggatg gataacttcc agaccagagt ggctgctgtg 30960
ggaccgggct ggtgaagcgg tatttcaaaa tacattttca ggtgtgtttg tccatgtggc 31020
atgaatgccc tgcattcata gtctctgcag agaggtgtgt tccctgggat atctttggtg 31080
gctctgttct atccctcaac ttacaaattg aaatcattat ttgttactgt tttctcccat 31140
gaaccttctg ttcctggcca gctgtacagc ctggcctcat ctcccactgc ccctcagacc 31200
agggtacagc catgcctgta agcacttcat tctcttctgt tccccccaga catttcactt 31260
ctcatctaaa tcctctcttt tcccttcccc gtcattttgt ccaacctctg ctctcactgc 31320
tgatactttt ctttatgttt catgacgtca gagcctgtgc tagacctgcc tgtacttggt 31380
cctgacattc tccatttgtc tcatgttgca gtataaaatc ttaatccata ttaaggtgct 31440
gtgcaaatct gagcacccct gttagggcaa gacatatgcc ttctgggcct ttgtttcacc 31500
catttctcct tgcacagtga caagggctcc cagagtcacc taatggtagc tatgttgatg 31560
aaagttccct gactcctcct tggatttttg agaactgggg tctcatcttg tcataagaat 31620
agcaaggttt gtatgggttt gggtctctga tggttcccat gactggtgga agacacagat 31680
ttagaatcaa gaattgggag gccgaggtgg gtggatcact taagttcagg agttcaagac 31740
cagcctggcc aacatggcaa aactccatct ctactaaaaa tacaaaatta gccgggcgtg 31800
gtggcgcttg tctatagtcc cagctactcg ggactgaggc acgagaatca cttgaacctg 31860
ggaggcggaa gttgcagtga gccaagatcc cagaactgcc ttctaaatga ctgtgggaga 31920
tttttgtcca gtcctgctag aagcaaaatg ctgtacctgt tggcttgttg gaagtacaag 31980
cctgcagtat ttggggggaa agtaggaagg gaagagggat tcagtagggc ctcattatca 32040
ttaatcgtgt tcctgaactt gaaagcacca tgggaaaatc ccctcccacc cctgcctctg 32100
tcctttctag ctgcttcctt gaggattatc aaaaagtgtg ggtctccggt gggctcctaa 32160
ttccttctta ggggatagag acaccttaga gaagcagggt aggtttgatg tatgaatcct 32220
tgtcactcgc actaaaagga gcactggttg cagcctgcac aaattcccaa ggtccacccg 32280
ccagctgctt tgacccagga acctgcgtgg taatgagatc agcagcctga gttctcgaac 32340
gatgttcaag gcaaacccta accctgacct tcccactcct gttgatgaga acggtgactc 32400
cattctattg gcatcaaagc ataaggcccc ttttttttca caatgcactt tttttgttgt 32460
tgttgagaca gtgtctctgt tgcccaggct ggagtgcagt ggcaagatta tagctcctgc 32520
agccttgagt tcctgggctc aagggatcct ccctcctctg cctcccaagt gcctggggac 32580
tacaggcatg caccactatg cctggctaat ttttttattt ttcgcagaga cagggtctca 32640
ctatgttgcc agggctggtt ttgaactcct ggcctcaagc agtcctccca ccttggcctc 32700
ccaaagggct gggattacag gcatgagcca ctgcacccag tccgcaatgc actgttaaca 32760
catggcacct agagcctgta atagtgaaca gccagtcttt ttcagcctca ggctaggtca 32820
ccagggaatc cagataccag atgccctcca gcctccattc cccacctcat ctctcaggaa 32880
acagatgcac aaagcaagtg ttttggtgct gcttccctca cagcatcccc atgtgcattt 32940
tgaggacaac ctttgtatct gattccaatt aatcaggttc tccaggagtt ggaatgttgg 33000
tttcaagtga ctgaacaata aagtggcttt cttcatcttt cttggccagt ccaataaaag 33060
tgtcaggtag cttttctctt gctaatggac acctaacgac accctggcct gttggtcttg 33120
accagagaaa ggccagctca gggcagctgg agctgaagag gcaaggacct ttctaatgag 33180
gacataagtg agggacactg gaaagaccaa aagagaatgg aaagtactga catggtagtt 33240
gcagggtgct agtgagcagt catgccccca aatcagccac cttacataga actccccaag 33300
ttcagggcca ctggatgggg ttgtgacgca gtcaagcagg gcccagaaag catacaagca 33360
gttggtttca tctcctgtaa gaaagtggca tcatccctgc tttgtaaacg gagaacctga 33420
cacacaccaa gagcactcct agccgtggaa aaaagccgct agaacccgag gttagtctga 33480
tttttggttc ctctgaaaat tagcttttgc tggatgctag attcagttct ggacttactg 33540
agtagtctct gggtttttga cattgttagg cactgtggga aaattataac aggtacgtct 33600
gcgctgagtt gcttgctaat tcctaggaga gacttggaca ttttggacaa ttaagaagca 33660
atacaggcca ggcacggtgg ctcacgtctg taatcccagc actttgggag gctgaggcgg 33720
gtggctcatc tgaggtcagg agttcgagac cagcctgacc agcatggtga aaccccatct 33780
ctactaaaaa tacaaaatta gccaggcgtg gtggcacatg cctgtaataa tcccagctac 33840
tcgggaggct gaggcaggag aattgcttga actggggagg caaaggttgc agtgatccga 33900
gatcacgcca ttgcactcca gcctgggcaa caagagtgaa attctgtctc aaaaaaacaa 33960
acaaacaaaa agaagcaata cagctctttg agaaagatgc agtcataagt ggtgcagagt 34020
tgcagtctgc ccattcctgc tcctcactca tcgctgttcc gaacaagtca gccaggaagc 34080
cgcactgcac caaggctttt aaagatacca gaaaacacct gtgaagctgg aggtgaccat 34140
tcaccaaatt cgaatccctc taatgatccg cagcgtaaaa tccctggaga aggtgtgtgc 34200
tgacttgatt cagaggagga aaggaaaaga atgtctaagt gaagggacca gtttgaatgc 34260
ctgccaagac tttgagaatc actataagaa aatctccttg tggtgaaggt tcagagacat 34320
gggatcgttt ccagatgaga atccacaagc tacccactga cttgcacagt ccttctgaga 34380
ttgttaagca gttgacttcc atcagtgttg agccaggaat tgaggtggaa gtcaccattg 34440
cagatgctca aagtcaacta ttttaataaa ctgattagcg gttgttataa aaaaaaaaaa 34500
aaaaagcagc agcaatatgg gttgagcgca gcggctcaca cctgtaatcc caacactttg 34560
ggaggtcaag gtgggtgggt tgcttgagtc caggagttca agaccagcct gggcaacatt 34620
tgaaatttta acttattttt taaaaaagaa agaaacatta tacccaatat ctgtcaattg 34680
atgactgcaa tgtggtatgt ctacacaatt gaatattatt aggtcattaa aaggaacaaa 34740
gtgctgattc tatgctataa catggaggaa gtttgaacac atgctaagtg aaagaagcca 34800
gtcacaaaag atcacatatt gtatgattcc attgatatga aatatctaga atagccaaat 34860
ccatagacag aaagcagatt agtggttgct tagactgggg ataggggatg gaggagtgac 34920
tactatgggt caggcatttt ttgaggggcg agggatggta aaaatgttct aaagtgagat 34980
tgtggtgaat gattgcacaa ctctgaatat acaaaaacca ttaaatggat gaatattaca 35040
gcatgtgaat tacctgtctg ctgtttaaat aaaatagaaa caatacaaaa tggaatgtaa 35100
ttgagtgtga atttgtgtga ttcaggcggt aactgtttta cagaaaatta gagatgagac 35160
attgatataa acaaggcttc ctagtttctt gttttgtttt aagacagggt ctggctgggt 35220
gcggtggctc acacctgtaa tcccagcact tgctaactga agatgcaagg accgaggcgg 35280
gcagatcact taaggtctgg agttcaagga cagcctggct aacatggtga aaccccatct 35340
ctactaaaat gcaaaaataa gccagccatt gtggcatatg cctgtagtcc cagctgctcc 35400
agaggctgaa gtgggaaaat ggcttgaacc tgggaggcag aagttgcagc aagccaagat 35460
tgtgccactg cactccagac tgggcaacaa agcaactctg tcttaaaaaa aaaaaagggt 35520
ctttgtcatc ccgtccagtg gcatgatcat agctcaccgt agcctccaac tcctgggctc 35580
aagcaatcct gtctcagccc actgagtagc tgggactaca ggcatgtgcc accaagtctg 35640
gctagttttt aaattttttt gtagagacga ggtctcacta tgttgcctag gctggtcttg 35700
aactcctggg ctcaaatgag cctcctgcct cagcctcccc aagtgctggg attgcaggca 35760
taagccactg cacccagccc ctggacgttt tggatggtgg actttgagta gtttggggta 35820
ggaggactct ggagtggcgc tgacagtcct caggaaggag taagctttgc catgccaggg 35880
aggatgcagc cgtgctgaaa gcatcccaac tggggagggg ggggggcgcg gtggggaggg 35940
acagcccctg gtagagagaa tggggctggg tggagagagt ggaagccaat tgcagggagt 36000
cttgaaggtg aggcagggat gtggatttta ctctgtacac agggtagatt ttgatcagga 36060
aaataatgtc aagcacatga cagcttggaa gcaggagtct gagctgcagc cccagggagg 36120
ccatttaaaa gattatcccg gctgggcgcc atggctcatg ccagcacttt gggaggccga 36180
ggcaggcaga tcacgaggtc aggagcttta gaccagcctg accaacattc cccttctcta 36240
ctaaaaatac aaaaattagc tgggcatggt ggcgcatgcc tgtaatccca gcaactcagg 36300
aggctgaggc aggagaatca cttgaacccg ggaggcagag gttgcagtga gccgagatcg 36360
cagcacttca ctccagcctg ggcgaaagag caaaactcca tctcaaaaaa aaaaaaaaaa 36420
aaaatttatc ccgagatggt tccggtaaag ggataggaca gagcatacct gagccacgtt 36480
tggaagggaa ccggggtcta aacttgcatc aggaggaaag cgagctggtt cttgaggctt 36540
ttacagatca cgtatagtgg agttttgttt gcacgttctg gttgggacgg gcaggaagtt 36600
acggatccaa gctggtatca gctagagcgg gtctcaccag ggccagtgtt cctttgctgc 36660
attctcttgg ggggaaataa atgcctgggg gttctctttg ctacattttt gtctttggga 36720
gctgcttttt tctctgggat cggctgcaat aggccttgtg atgccagagg gtaagaattc 36780
aagtttactc ttgaccaatg ggttgcacag atcacaagct gcaaaatatt taatcaccga 36840
ggtcatttga gggaaatgag atttgatcaa tagaagtgtc tgctctgttc cttaagagtt 36900
gagtctaaac tgcttttctc cttaccttcg tttggcaaaa ccacagacca ttaaaaatgg 36960
aaagaataac tttttctaag gcccacaaaa gcttattttt aatcagttgt gtggtctact 37020
cacctttgtg gtgttcccct tgaccggact cacaaaaata aacgtgtgca agcctagtgg 37080
tttctgagcc cttttaaagc agtacccctg tttctgacaa ctcttattta agataaagcc 37140
catgggtcaa tgcaggactg ggtctgcaac cttggccccc ccaagagaaa ccactgtcag 37200
tccctgtcag ttgctgatca tgatgcgcgg gacacccatt ttcattttta aggtttctag 37260
cggaagcctg ttgagcactt gaggaagacc gtgtttcaaa taagggggag tgaaagagaa 37320
aagggagagt agaaaggaag gcagtgaaga gccagagtga ctgcacgtgt ggtatttatt 37380
gagcaagcat ttcttgagca actcctgggc gccaggcatc gtagtaggtg ctggggattt 37440
aaaggtaccg atgacacatc accgcactca ggttcagaaa gaggactgcc cttcagtgtg 37500
acaggtgcca ggagggggag ggcacctaac ccagactggg agtcagcacc gccctggagg 37560
agaagtcacc agctaggctg agacagaaga gtgagtagtg agagctggac agaaaaaaat 37620
caggggccct gtggccactg gggcagccgt gagccacagc aggggctgag ggagaacatg 37680
ctgtttcaga gccttatgca tcggggagcg gcagtcgctc cactgagtct cttagggtga 37740
acaaatggtg agaaaagtcc tctccaaggc tgtgggcggg atgtgggtgg taggtgagag 37800
gtggaagatg ccaggagtac atttgaacat cctaaaagga aatagaaagt tcatttcccc 37860
tcgtgagtgc agaggggtgt gctcaggaga tgggtaacag cccaggatgg tgaactcagg 37920
tgtgtccggg ccacgggcct tcttgaacgc gtgcgggaag aggcactggt caggggaggg 37980
acaggtgctc ttggtggtat cagatcttgt gaggtgcaga caccccggtg ggtccagtgc 38040
tcccacccag ggacagagaa ggatggggca cggggaggga gagtggatgg tggggggcct 38100
gagggtgtgc ccagtcagag ggctgaggag aaaggacctt tgtgtgcgac agctcctgct 38160
gccagagcaa gtgtgggttt tatggcagct gtggcctccc gtcctaatat agtcaacagc 38220
tccaaatccc ctgccctgac acctgttagc gagaggttcc ctgagctgac ctctccttgg 38280
gctgcccccc cagcatgtgc atctgacgcg tcgagggcca gacccccacc ctctccgaat 38340
cacacgcatc ctggtcagcc cccagttgac aaattgcctt ctctcgactt gggcaggggc 38400
tgctggggtt ttgaggggcg gggtttgttc agctgttgct agggaagggt gaggctgagc 38460
tatcccaaag gaaatggggt gttcctctgg caagtggcaa tcttggcaaa gaactgagca 38520
tctggggagg gggcaactcc ggacacaaag aagtcctggg gagggccgac ctttcccctt 38580
aggatggggg aaatgaaatg cgcttaatgc tgctacagct gcttcctaac tttgcctctt 38640
tcttcctttg acttttggag gagtggggtg gaaaagagat gggggttccc aggcagccag 38700
ctgttttccc cactgaccca tgctccaatt cccactgccc tggctcagta gcctccagta 38760
agtgatgccc aggatggtgc ggctccgtgt ggccagcgta attccctttg tctctcccct 38820
cctcccctct ccctgtcttc ctctctcgcc ccttggcttc ccttcccggc cccgtggtgg 38880
ctgcagccca gccctgggga gcccctgtgg aagtggagtc cttcctggtc caccccggtg 38940
acctgctgca gcttcgctgt cggctgcggg acgatgtgca gagcatcaac tggctgcggg 39000
acggggtgca gctggcggaa agcaaccgca cccgcatcac aggggaggag gtggaggtgc 39060
aggactccgt gcccgcagac tccggcctct atgcttgcgt aaccagcagc ccctcgggca 39120
gtgacaccac ctacttctcc gtcaatgttt caggttggta gccaagccct gcccttgccc 39180
ctccctagac ccaccccctc cagccctctc tgccagtttc agaggaaggt gaacctcctc 39240
cccctccgtg atctgccccc actctgcttc agaaactgct gcccactaac attgctccct 39300
gcctgccgcg tggcttggct ctcagagagg tgactaggtg gggtgggccc cagggccgga 39360
gatctggggc ttccaggaca cacctcggag gtgattgcca gggctcttgg gatgttaaga 39420
ccctgtgatt tttttccacc acagcttgcc cagatctcca ggaggctaag tggtgctcgg 39480
ccagcttcca ctccatcact cccttgccat ttggacttgg tactcggctt agtgattaga 39540
ggccctgaac aggtggtggt atccctgctc tgctggagag gaacccaggt gcaccgcaag 39600
ggagctgtgc gagggcagcc agggagccct ggagctctgt gaacttggga acttgccact 39660
cttagaatgt gactttcaca aaactaggag ttgaggaagt ggagctgaaa ttttctttat 39720
gccatttatg cacctcaggg tgtggacttg gcagcagatc cccaaaggtg ataggaagga 39780
ctggagaaag atctggcatg aaccctgatg ggtgaccaca tgtgtatcaa gcgtgttctt 39840
acaagaaata aatacttatt ggggagaggt gttggcagct gctggggtgg tgggtgccct 39900
atctgctctg attaaggagg gcagccccca aaccttagta gacacatgct agaaaaattc 39960
tgactgtggg gtgtttagcc catcctttgg aaatagcatc tagccacagt gtgtctagac 40020
ctgcctgggt ttccctatag tcagccgtcc aaagaagaat acaggttgcc tggctccagc 40080
acacccaggt ggcaccacaa gttgagaaag cgcctttgaa tgtaggacgg aattaagtta 40140
aataggaaca gctgaccctg atggaaccac ccagtgtgaa ggcttccagg cagtgggggc 40200
agtgcttcgg ggaaggaagc aaacacgcac aggaactgtt cttaaacagt ttccatccca 40260
ccaagagatc atcactaagg gagcagtggg actgggatcc ccatggggag ggtgtccgtg 40320
ttcatctgga actgcactag ccttggtgaa atctaggggt ccctaggagg aacctcagtg 40380
ccccttcttc ttcccataga tgctctcccc tcctcggagg atgatgatga tgatgatgac 40440
tcctcttcag aggagaaaga aacagataac accaaaccaa accgtatgcg tgagacactg 40500
tttcctatct tactgccctt tgggtctggg cattgggttt aagaggggag gggaaggctg 40560
aaaggggagg aagaggaggg cacatggggt cacggtgcct gttctgctaa gtgccaggca 40620
ctgctcacag gtgttgggca gatgggcaag acacctccag gtcctggcct gggccctgct 40680
cctgagcctg accagctgct cctctccacc ctgcctgtct ctcttggctt tccccgggca 40740
gccgtagctc catattggac atccccagaa aagatggaaa agaaattgca tgcagtgccg 40800
gctgccaaga cagtgaagtt caaatgccct tccagtggga ccccaaaccc cacactgcgc 40860
tggttgaaaa atggcaaaga attcaaacct gaccacagaa ttggaggcta caaggtacgt 40920
gtgtgtgcat gcgaaagtta gagtaatggg aacaggggag gccgagttag gaagtcctga 40980
ttacatgctt ttcatttttt taagtaatac tttccaccta tacaggttat tcattaaaat 41040
ttttaaatac aaaaaaatgc aaataaagtt taaacatttc ttcagtcttc tttctgtaat 41100
atggttttta catagttgat cacatcatgt atgtaatttc cttgccttgt catttgttaa 41160
catgagtctt ttcctgatat atttcaagca tgaatatttg aaacataatt tttcatgact 41220
gtataagatt ccattatttt aaaatcccat aatttggctg ggcatggtgg ctcacgccta 41280
aaatcctatc actttgggag gccgaggtgg gcggattgcc tgagctcagg agttcgagac 41340
cagcctgggc aacatggcga aacctcctct gtactaaaaa tacaaaaaat tagccatgtg 41400
tggtggcagg ctcctgtaat cccagctact ggggaggctg aagcaggaga ttgcttgaac 41460
ccaggagaca gaggttgcag tgagctgaga tcacgtcatt tcactctagc ctgggtgaca 41520
gagtgagact ctgtctccaa aaaacaacag aaaaagtcct ataatttaat gaactatttt 41580
gtgatattag gtattttctg gtttttcacc ataataaata atgttgcagt gaatctctgt 41640
cagcattttt ttaagcgtgc ttccttagga cagattgtta caagtgaaat tactaactta 41700
aagggtgtaa gcattttttt ttttttttta gacggagtct cactctgtca cccaggctgg 41760
agtgcagtgg tgccatcttg gctcactgca agctccacct cccaggttca tgccattctc 41820
ctgcctcagc ctcccgagta cctgggatgt gcagccacca ttcccagcta atttttgtat 41880
ttttagtaga gacggggttt ccccatgttg gccaggctgg tcttgaactc atgacctcaa 41940
gtgatctgtc cgcctgggcc tcccaaagag ctgggattac aggcttgagc caccgcaccc 42000
agccagaaat attttaaatt aattcaccat gcactcacta catgcaagac accatgcttt 42060
aaatgctgca agatagcgtt cctgcccata aaaattttgc agtctgatag gaggcaaatg 42120
tccatgagca gctaccgtaa aaagtagact gtgatcagtg ctttggtagg cagagaggaa 42180
agggtgagca cagttctgac cagagactgg actggaggag atggtttttg aaatgagctg 42240
tcaaggacag tgggggctgg attcttagtg taataggaga ggtgcacagt tgggaacatt 42300
cttggtgtat ttgggagtgt ttgcagaagg cacatctgtc cggatcacga atgatcttga 42360
acgtcacagt ggagacttct ggagtcttta caccccatct gccagcttgc agagtgtgaa 42420
cgggctggta ggggggcaat ccacgccttg tcctagccaa ccctgcagcc tggggccctg 42480
tgccaccagg ctctgatatg gagggcaggt gccacggggt gccgacattg tcatggggcc 42540
tgcattttcc tctggaccct caatgtatcc ctttggcatt tcccctcagg tccgttatgc 42600
cacctggagc atcataatgg actctgtggt gccctctgac aagggcaact acacctgcat 42660
tgtggagaat gagtacggca gcatcaacca cacataccag ctggatgtcg tgggtaagag 42720
ggcagaggca gcaggaggaa tgagtttagt gggaagagcc aggcttggag aacacagccg 42780
gggtgtccag gtttcttagg ggcagagtca ggatagcgat tggcacttct tggctttgtc 42840
accttgagca ggtcacttct cccttttgag cctcactttt cttatctgta aaatagagtt 42900
aagatcagac agtaacacgg tcaaagctgg ttgtcactgt gaaattgaag gtgctgttca 42960
gagtctgtcc tgaaggaggc gttgttggag aggtgttaaa tgtagcgtaa taggagctgt 43020
cgcttaatgc tagcaagatg ccaggctcct taaatacctg ccctgtaatg ctcatggcac 43080
acctgcaagg tgggcagtat tagtctagcc ctgcacagga gcacaggcgc ataggctcag 43140
agaggtcaga caccttgcta atgcagaact gcacacctgt gccaacttca gggcatcaca 43200
ggagactctg ggaagaacat tgagcctctt ggagctatta ccgcaacctt ttccttctag 43260
gagttctgaa actcactccc tagagatcat tgggtacaga atctctcagc cagtgttctt 43320
cttgattatg atgatatggt ctaagaagga gattgtggcc aggagcagtg gcttatgagc 43380
tccaggtggc atgatgggat tactcacgcc tgtgatccca tcactttagg aggccaaggc 43440
tggaggattg cttgaggcca ggagtgtgag accagcctgg gcaacacagt gagaccctgt 43500
ctctataaaa aaatttaaaa attagcctag tgcagtgtca tgtacttgta gtaccagctg 43560
agttaactga ggctactgag gtgggaagat cacttgagcc caggaattcg aagctgcagt 43620
gagctatgat gacacccttg tgctccagca tgggtgacag agtgagaccc tgcctttaaa 43680
aaaaaaaaag gtaaaaagga gattctgatc caagaggttg gggtaagatc tgagattccg 43740
cgtttctaac aagctcctag gggatgctgg tagcactgct cgtggaccac actttgaata 43800
gcaggagtca aagtgactct ggttttttaa ggaggagcag gttgtgctga ggtctggggg 43860
tgcaactgaa ttagaaggtt ctccattaaa gcatgagcga cttactgtga ctgtaaatat 43920
gatgactgcc ttggggagga ggatcctgat ggcttagggc ctgaagagag ggtgtccctt 43980
tccccagctc tgttttgaga ggcttgggct cagcagaagt gctgggaggt ttacaaccca 44040
tcactgggaa agccaagtgg ggcgcaggtg agcccacccc tctttagcca tggcaaggtc 44100
cccatgacaa gtgcctcctc tcccatcttc cacagagcgg tcccctcacc ggcccatcct 44160
gcaagcaggg ttgcccgcca acaaaacagt ggccctgggt agcaacgtgg agttcatgtg 44220
taaggtgtac agtgacccgc agccgcacat ccagtggcta aagcacatcg aggtgaatgg 44280
gagcaagatt ggcccagaca acctgcctta tgtccagatc ttgaaggtaa tcatggcacc 44340
agtcttcgtg ggccagtcta ctgggaagga gaccactgtc tcgggggctc aagttcctgt 44400
gggcaggctc agttgccccc gaatgggatc attcctcacg cttcaggcac acacactcca 44460
tctcagtagg gatctagcca catcccccag gactagtaac agaggtcaca aagtggaggt 44520
gagctgggaa cagagggctg cagggatggg tggtgctggt ctgtaataag ctttgagagc 44580
aacgtcactg gggctttggg gtcagctaca caaggaaggc atttggaccc ctgccttttc 44640
attgcccgaa accagagcct ttccaccaag cgtttcccag tcttagccct gtgtcctgag 44700
ttacgtacga tctttctggc aaatggggtg catgataaga gcatctctta cgaagagttg 44760
gaaaaacaaa tgccatatat aaattctaag ccatatgagg acgaggagta atggcatttt 44820
cttccttttt cctctcactc ccagacattc attgtccctg aatgctccat taatccaggg 44880
aaggtaattg cctaaatctc cagtggatct cgcaacagga aggaaccaga agctgggaaa 44940
gttgtttacc tctttgtccc agagttagac ctcatcctcc cctagcttag ctgtctcaga 45000
gatatactgg ccctcccttc tcttctcttt gctgctggtg ctaaaactgc tctgtaggtc 45060
attggccact gtctccactc acaacccctg ctccagtcct ggagggagtg ggttaaacac 45120
aaatagaaca ttccatttga agcagtgatt cttttttttt tttttttttt ttaatcaaat 45180
gctttggact tttgaagtcc acttgttctg tacttgtaaa agggaaagaa ggccgggcgc 45240
agtggctcac gcctgtaatc ccagcacttt agatcacttg aggtcaggag tttgagacca 45300
gcccggccaa catggtgaaa ccccatctct actaaaaata caaaaattag ctgtgcatag 45360
tggttggcac ctgtagtccc agctactcag gaggctgagg caagctaact gcttgaaccc 45420
agaaggcaga ggttgcagtg agctgagatc acgccactgc actccagcct gggtgacaga 45480
gtgagtgaga ctctgcgtta aaaaaaaaaa aaaaaaaaaa aactaaaagg gaaaggtaat 45540
aaatctcact taacatctcc cttcgctccc tgggcctgcc tgaaagttac acgggagcaa 45600
cgtgcgtggc cacatctcag ctttgcccaa ctgactggtg tgtcgttggt ttgttccagc 45660
attcggggat taatagctcg gatgcggagg tgctgaccct gttcaatgtg acagaggccc 45720
agagcgggga gtatgtgtgt aaggtttcca attatattgg tgaagctaac cagtctgcgt 45780
ggctcactgt caccagacct gtggcaaaag gtaatgggga gatggatggg accctgtgct 45840
ggggatttga tgtaggcccc aagctgctgg ggcaggcggg gaagccagta ctggactgtc 45900
cttgccaccc tactgtattt ctagtgccca gagccatgga aaaatacccg gcctgggagg 45960
ctggtttggt ttggtattgt gttggtgtct gtgggttccc tctctgcctt ctgtgtgttc 46020
cttggctttg tgtggatcca tgtgaggact cacggggaca cggttttgct gtgttacaaa 46080
tggtacttca gactgaagtt gtgagtgagt ggtgattaag agaaggggcc ataggccagg 46140
cacagtggct cacgcctgtc atcccagcac tttgggaggc tgaggtggga ggatcgcttg 46200
aagccaggag tttgagacca gcctgggcaa catagcaaga ccccatctct acaaattaaa 46260
taaattagcc aagtatggtg gcgtgtgcct gtagtcccag ctagtctgaa ggctgaggca 46320
ggaggattgc ctgagcttag gtcgaggctg cagtgagcta tgtttatgcc actgcacccc 46380
agcctgggtt gacagaatgg taccccatct cttaaaaaag agagagaagg ggttaggcat 46440
tcccttgcat actcgcatct gctggctgtg tatgcacatg tgcgtgtgtg tatgcgtgtg 46500
catgtgtgtg tctgcagccc ccgccatccc tcctgtgttc accttctggc tatctttacc 46560
tgaaaccaaa cagcccctgc ccgccggccc catttctcca tgccgctcac cgcccgcatg 46620
ctcggatggg ccagtggctg ccagcatctg gtgaagggtc gtaaccagcc atcgtcttct 46680
caggtctgcc ggagttcttc cctcagggtc tcaccctctt cctctaacag gttttgctgc 46740
ctggtggttt tcgtttgttc cttgttgcaa agaagatgtc agggagcatt tcttcctcta 46800
gtcccccttc tttctgtctc cttcccttgc tctgcgtctc ttagaggtct catgtcctgt 46860
gcttgtccat tttgcttccg ttgtctcttc tagactgctg gagttaatac caccgacaaa 46920
gagatggagg tgcttcactt aagaaatgtc tcctttgagg acgcagggga gtatacgtgc 46980
ttggcgggta actctatcgg actctcccat cactctgcat ggttgaccgt tctggaaggt 47040
acacactgta acttctcctc tcgatgtcct gccctcgcca cgggcacggg gggagcatgc 47100
atttccaggc ttggggagac acagaggcag gagagctgga agaatgggct cctgcctgcc 47160
tggtgccaca tcctgcccca gctttgaggg ctgaatcctc tcagctcaga gaagagcttc 47220
cctagttttg caggcgcacg gaggcctccc acccgtacac ctgcctctgc tctccccctg 47280
gccattgcaa tgcatgcccg ggatctgggt ttaccctgca gcccgactcc tccagggcag 47340
gctccttccg tccttgggtc cagcagcctc ccccctccgc tgggtactga gcatctgaaa 47400
agtctcagat agggccctac acctcttctc ccttctcaag tgctcagccc aggggtgggg 47460
cttgctgctt gcaaagagca gcccaccctc ctgtactgcc atcctattgc ctttgaagaa 47520
ggaggtcagc ctggacaggt gaactgagtt gccttcagaa aggcctgtct caggcagccg 47580
cagcaggctt cacgatgtcc atgtatcctg tttgcctgct gccgtctctc ctctcccaag 47640
aggggaggtc tgcgtgttga gccagggagg aaggagcctg cagcctgctc agggtggtgg 47700
ctggtgactg cggggccagg gcttgctgct gtctctcgga atgtcctgca tgtgggtctg 47760
gctgttcctg ctggcactgc cctcttctct ctcccctcct ttcccactct gccctgcttg 47820
cccgtcaggg tctccggatg cccctgctgg aggcagagaa gcgttctgtt tttatcatcg 47880
tccctgtctt ggtcctgtcc gtgctcccca tgtgctccca atcagttgtc ttcgttcctc 47940
aacatcaggg aaagaaaaaa cagcaacact tctccctgtc atcagctctg ctgtctcctt 48000
gtcaggcctt gggacgttct ctgggctcag tctagggtcg tgcctcatgc ctcatgcctc 48060
tctgggaagg ttcccagggg cgccgcctcc atggttggct ggtgggtttt aaaggggaag 48120
gttgggagga ggcctgtgga aggaggaggg ccgtccacac ccgtggggca aagcgtgttc 48180
catgaaacca gtgctgtgcg tgctgggatg aaagcctccc agcctctcgt gctgaaggga 48240
aaggtggacc gaactggctt agctgctgtg gcaatggggt ggggggtgag tcctaatcag 48300
aaggtgggag aagagaataa caaaatggaa ctccgccccc tgccgccaca tttccttaag 48360
ttttaggagt tggggcctat gagtagaatt tgaaagaact accaaaaaag cttatttttg 48420
gaaattaagt cagctttgcc tgtggtttgg ctaggaataa atatttacct gtgtgcccct 48480
acagagatga cacagaccca aagtgggaca ttgagcaagg cacaggctgg ttcccctcct 48540
gtcctctgtc ctcattctgt gagtgccacc atcaccaggt actgtggcct gcagaaataa 48600
acgaggcacc aaccctgccc tcagggaccc cgtgtcttct tagggacaga ggactcagaa 48660
acatctgtgt ccccgcatgt taagtgcatg cacacagtgc tgaggctttg cagagaaggg 48720
ccatggctcc ctgaggagac caagaaaggc acatagaagt gacttctcag ctggcccttg 48780
caggatccct gggtgcctgt acctctccag tccagctgag caaggaggct caggaattaa 48840
tgaagatggg gcttgtgtag cacgatggtt ctaggccatc ccttttccat ggctcaagtc 48900
cattgaaggc agcctccaaa atcagggggt tgcctgatcc tcctagtgcc acaatcccag 48960
tcctagctag aacttgccat ggttcttctc cctaaaagtt cccaggggac aggagacagg 49020
tgttgctttt ctaatggagc gggacctcgc atggacgggg ccctccaagc ctgctaacac 49080
cctgttcgca ctgactcagc cctggaagag aggccggcag tgatgacctc gcccctgtac 49140
ctggagatca tcatctattg cacaggggcc ttcctcatct cctgcatggt ggggtcggtc 49200
atcgtctaca agatgaagag tggtaccaag aagagtgact tccacagcca gatggctgtg 49260
cacaagctgg ccaagagcat ccctctgcgc agacaggtaa cagaaagtag atgggggatt 49320
tgcacactca gcaccacctc tctctctggg cctctaatgc cctgccctct ccattgtccc 49380
taatttatag ctttgggcct tattttctgg cttctgggca aggcacagtg gaatatcatg 49440
aactaagtgc tctagagtct gtttcaagct agtgtagccc gtgaatttcc tgcaccctcc 49500
atatcacact gcaagtcctc cggactcctg ggacatggat tgggaggaag tcctatttgg 49560
acagaatgtg cagccaatag catgaatttg aactgtcccc aagggctgct tagaagtgca 49620
gagatgcagg gtagagaaga gaactgtttg tattagtcca ttttcacact gctgagaaag 49680
acatacccaa gaccgggcaa tttacaaaag aaagaggttt aatggactca cagttccacg 49740
tggctgggga ggcctcacaa ttgcagaagg caaaaggcac gtctcacatg gcggcagacg 49800
agaagagagc ttgtacaggg aaactcccct ttataaaatc atcagatctc gtgagattta 49860
ttcactatca caagaacagc acagggaaga cctgccccca tgagtcaatg acctcctacc 49920
aggtccctcc cataacacgt gggaattcaa gatgagattt gggtggggac acagccaaac 49980
catctcagcc ataccatacc cttgtcccct gtgtgcccac ccttccccac gggaggaaat 50040
ggtacagatg gcacaggtgt gtgcaagaat gaccgttccc tcagaagcct gtgctcattc 50100
tggaaggtgc tttgggagtt aggaatccat aagctaaggc aaagtatttg caaagagtca 50160
ggagaacaga gttgttactg caatgatcag ttataaaatg tcaagctgga agaggtgcat 50220
ttggtctgct tattttaaag gtgagtgaag tccagaaagg ccagcttgtg gcagaaatag 50280
gtcagtccta gaagttgggc ctcctggcct accatggtct ttggaccact ctgtgttgag 50340
gaaagaacat cagatacaca gacatgtgcc tctgccattg ttgggaagcc ctgactaaga 50400
atgggaagga gtcaccccgt cccccctcct tgctctaggg tgaccccact cttccttgca 50460
ggtgtctgct gactccagtg catccatgaa ctctggggtt cttctggttc ggccatcacg 50520
gctctcctcc agtgggactc ccatgctagc aggggtctct gagtatgagc ttcccgaaga 50580
ccctcgctgg gagctgcctc gggacaggta ataatacttt gactcccaac tttttgaagg 50640
cattccttgc ttgctattct agtggtggaa ggtgtgtata ctaacacctt ctgggcggtg 50700
aaggttcatg aaatgcctgc agaaacattc attccacttt ctgctcgcag ttgggtgaaa 50760
tacagagagg tggagatggg gtgcctctca aggtttgaac ttcaccagcc ccaacttatg 50820
ccactctctg tttcccccga aagactggtc ttaggcaaac ccctgggaga gggctgcttt 50880
gggcaggtgg tgttggcaga ggctatcggg ctggacaagg acaaacccaa ccgtgtgacc 50940
aaagtggctg tgaagatgtt gaagtgtaag tgatgcttct gtccttgcaa agaaaatctt 51000
gtcccattcc aagcaaacag caggcctcgg gcccagcaga acagcttctc tggtgccttt 51060
gctgcccaca cctgctccgc tgcctgcttg gggttacctg ggagtggagg gggtgttctg 51120
caccttgaga ttgttctatg acgtcactct gttccttggc gtcaacctgg gctgtggtca 51180
ggtgtttatc ctggatccat cgcttgcagg ctttcctcac cacatccctg cccactcact 51240
accacctatt gcaacaacgg ctcccatgag agggaagaga aaacaagttt ggatgaagtg 51300
gggaggagag aatcaagtcc cagggaaaag cagcccctcg acacataccc cactccctta 51360
gcctttatcc tgccctcctc ccttcccaag taaatgagtc tcaacgtgtt ctttaaagcg 51420
gacgcaacag agaaagactt gtcagacctg atctcagaaa tggagatgat gaagatgatc 51480
gggaagcata agaatatcat caacctgctg ggggcctgca cgcaggatgg tgggtgccgg 51540
ccagactggc tttccctgcc cagcggggag aagatctgag ctggggtatc agtcccaagg 51600
cctctctcag ccacagctag ggaagggggt taagagaggc tgctttggca gaggtttaaa 51660
atgtgttatc tcgggatctg ggctccgctc attggtgttc attcaggaat acagatacct 51720
agattcacac acgtggtgtg ttaacagagg cagctgagta attatggtct aagagcgctc 51780
aggctgggtg cagtggctca tgcctgtaat cccagcaatt tgggaggccg aggcaggaag 51840
atcacttgag atcaggagtt cgagaccagt ctggtcaaaa tggtgaaacc ccatctctac 51900
taaaaaatac aaaagttagc caggcatggt cacgcatgcc tataatccca gctactcagg 51960
aggctgacgc ataagacttg cttgaacccg ggaggtggag gttgcagtga gccaagatca 52020
cgccattgta ctccagcttg ggagatactc ccgctgtctc aaaaataaaa taaataaata 52080
ggccaggcac agtggctcac gcctgtaatc ccagcacctt gggagggtga ggcgggtgga 52140
tcacttgagg tcaggagttg gagaccagcc tggccaacag gtgaaacccc atctctacta 52200
aaaatacaaa aagtagccgg gcgtggtggc gcatgcctgt aattccagct actcgggagg 52260
ctgtggcagg agaatcgttt gaacacggga ggcggaggtt gcggttagcc gagatcgcgc 52320
cattgcactc cagcttgggc aacgagcaaa actccatctc aaaaaaaaaa aaaaaaaaaa 52380
aaaaaattag ccaggcattg ttcatgcctg taatcccagc tgcttgggag gctgaggcag 52440
gagaatcact tgaatccaga aggcagaggt tgcagtgagc cgaaattgcg ccactgcact 52500
ccagcctggg caacagagtg agactccatc tcaaaataaa cagacaaact ggggctctta 52560
ccccaatgtt gctcgggaat tttctggact atgctgggag taattatttc tctgattttt 52620
tttgggtagt agaatggatt tcccaggtcc cctaagagga ggcaggagat gggaggttgg 52680
ccggggtgtg ctgctggggg tggggtttct ttgaggtgaa gccaaacctg ctcacctgct 52740
gctggcccca tggcctcttc tcctgtgcct gcaggtccct tgtatgtcat cgtggagtat 52800
gcctccaagg gcaacctgcg ggagtacctg caggcccgga ggcccccagg gctggaatac 52860
tgctacaacc ccagccacaa cccagaggag cagctctcct ccaaggacct ggtgtcctgc 52920
gcctaccagg tggcccgagg catggagtat ctggcctcca agaaggtgtg gaacctgaag 52980
gctcccctgg gtaatgccag ggtgggaaca gagcccccct agtcttccag cctgtgactt 53040
atcatcttgt ggtggcgttg tggatgcact gagcactggc cctgtgtgcc ctgtgtgttg 53100
tcttaggctc tctgggaact gcagagtcag gagcaccagt gtagccaggt ggccttgggg 53160
tcagactgat gcagggtccg atctgtgcac tgccactttc tgcgtagcct caggcagcta 53220
cttagcatct taaaattctt caaatacaaa ataataataa tatcagctgg gtgcagtggc 53280
caaggcggga ggattgcttg agctcaggag tgtgagacca ggttgggcaa tatattgaaa 53340
ccccgtcttt aaaaaaaaaa aaaaaattaa aaaattagct gggtgtggta gtgcgtgccg 53400
atagtcccag ctactcggga ggctgaggtg ggaggctagc ttgagcccaa gagtttgagg 53460
ctgcactgag ccatgatcac accactgcac cccagccggg gcgacagagc aaggccctgt 53520
ctcaaaagaa aataaagtat aacaatacct gttgtagaat tgttatgaag ataaaatgaa 53580
actgtctgtg agtgttgagt gcagtgtttg gtgtgtaagg gctggcctgg tttgagccca 53640
gccccatgtg gacttgctgt gctgggaggc aggacctagg agcatgcatc gctgcagacg 53700
cagcagaggc ataaggggcc agtctttggg gaaggaaggg aggagcgctt gctgtgatga 53760
gaagcctgga gctggcagag aatgttagaa gagggaaagc aaaggttcgg ggggcagagc 53820
agtgtggcag aagttctatg agacaagtcg gctagttgca tgggtggcgg ccgcccagag 53880
ccttccagct ccctcacctc cccgcctccc gctctccctt cctccttcct cagtgcatac 53940
accgagacct ggcagccagg aatgtcctgg tgacagagga caatgtgatg aagatagcag 54000
actttggcct cgcacgggac attcaccaca tcgactacta taaaaagaca accaacgtga 54060
gtgccgacaa ggccgccctg tgctggtggt ttcatctgag aagcaaggag tggggtgggc 54120
tgagaaccca ccccccagtc ccttcccacc tgtgccctca tggccctgcc tggggccact 54180
ccaacctccc ctgtgctgct ttcagggccg actgcctgtg aagtggatgg cacccgaggc 54240
attatttgac cggatctaca cccaccagag tgatgtgtga gtttgtaata gcaattgcca 54300
gggaggtgtg ggatagagag cttctagcac tgtagagtcc tgctttctcc ctggactgag 54360
gagtcctctt tctgccccag agagaaaaac aaaacattgt ctgtggccat tccctctgct 54420
ccagatgttg aaaggctgat ctgttctcca tgctgtctcc tggcactgcc ctgggtagag 54480
gatttgtgct gggggagggg aggcggagaa gctctaacac cctgtggctc tccgcccatt 54540
tgcaggtggt ctttcggggt gctcctgtgg gagatcttca ctctgggcgg ctccccatac 54600
cccggtgtgc ctgtggagga acttttcaag ctgctgaagg agggtcaccg catggacaag 54660
cccagtaact gcaccaacga gctgtaagcc cgaggagatg tcggaggccc tgagccaggc 54720
cttggggcaa gagtgggctt gaggggcagg gggctagact agagagtatc catctccagg 54780
agacgtccct gaccttacag tcctgccgca ggtacatgat gatgcgggac tgctggcatg 54840
cagtgccctc acagagaccc accttcaagc agctggtgga agacctggac cgcatcgtgg 54900
ccttgacctc caaccaggta aggctgcccg tgccagagcc agagctcagg ccgtccccac 54960
tgcgtgcacg cacctccctg agcagggagg aggggcccgg cccatcgctg cttcctctcg 55020
cccatcacag gagtacctgg acctgtccat gcccctggac cagtactccc ccagctttcc 55080
cgacacccgg agctctacgt gctcctcagg ggaggattcc gtcttctctc atgagccgct 55140
gcccgaggag ccctgcctgc cccgacaccc agcccagctt gccaatggcg gactcaaacg 55200
ccgctgactg ccacccacac gccctcccca gactccaccg tcagctgtaa ccctcaccca 55260
cagcccctgc tgggcccacc acctgtccgt ccctgtcccc tttcctgctg gcaggagccg 55320
gctgcctacc aggggccttc ctgtgtggcc tgccttcacc ccactcagct cacctctccc 55380
tccacctcct ctccacctgc tggtgagagg tgcaaagagg cagatctttg ctgccagcca 55440
cttcatcccc tcccagatgt tggaccaaca cccctccctg ccaccaggca ctgcctggag 55500
ggcagggagt gggagccaat gaacaggcat gcaagtgaga gcttcctgag ctttctcctg 55560
tcggtttggt ctgttttgcc ttcacccata agcccctcgc actctggtgg caggtgcctt 55620
gtcctcaggg ctacagcagt agggaggtca gtgcttcgtg cctcgattga aggtgacctc 55680
tgccccagat aggtggtgcc agtggcttat taattccgat actagtttgc tttgctgacc 55740
aaatgcctgg taccagagga tggtgaggcg aaggccaggt tgggggcagt gttgtggccc 55800
tggggcccag ccccaaactg ggggctctgt atatagctat gaagaaaaca caaagtgtat 55860
aaatctgagt atatatttac atgtcttttt aaaagggtcg ttaccagaga tttacccatc 55920
gggtaagatg ctcctggtgg ctgggaggca tcagttgcta tatattaaaa acaaaaaaga 55980
aaaaaaagga aaatgttttt aaaaaggtca tatatttttt gctacttttg ctgttttatt 56040
tttttaaatt atgttctaaa cctattttca gtttaggtcc ctcaataaaa attgctgctg 56100
cttcatttat ctatgggctg tatgaaaagg gtgggaatgt ccactggaaa gaagggacac 56160
ccacgggccc tggggctagg tctgtcccga gggcaccgca tgctcccggc gcaggttcct 56220
tgtaacctct tcttcctagg tcctgcaccc agacctcacg acgcacctcc tgcctctccg 56280
ctgcttttgg aaagtcagaa aaagaagatg tctgcttcga gggcaggaac cccatccatg 56340
cagtagaggc gctgggcaga gagtcaaggc ccagcagcca tcgaccatgg atggtttcct 56400
ccaaggaaac cggtggggtt gggctgggga gggggcacct acctaggaat agccacgggg 56460
tagagctaca gtgattaaga ggaaagcaag ggcgcggttg ctcacgcctg taatcccagc 56520
actttgggac accgaggtgg gcagatcact tcaggtcagg agtttgagac cagcctggcc 56580
aacttagtga aaccccatct ctactaaaaa tgcaaaaatt atccaggcat ggtggcacac 56640
gcctgtaatc ccagctccac aggaggctga ggcagaatcc cttgaagctg ggaggcggag 56700
gttgcagtga gccgagattg cgccattgca ctccagcctg ggcaacagag aaaacaaaaa 56760
ggaaaacaaa tgatgaaggt ctgcagaaac tgaaacccag acatgtgtct gccccctcta 56820
tgtgggcatg gttttgccag tgcttctaag tgcaggagaa catgtcacct gaggctagtt 56880
ttgcattcag gtccctggct tcgtttcttg ttggtatgcc tccccagatc gtccttcctg 56940
tatccatgtg accagactgt atttgttggg actgtcgcag atcttggctt cttacagttc 57000
ttcctgtcca aactccatcc tgtccctcag gaacgggggg aaaattctcc gaatgttttt 57060
ggttttttgg ctgcttggaa tttacttctg ccacctgctg gtcatcactg tcctcactaa 57120
gtggattctg gctcccccgt acctcatggc tcaaactacc actcctcagt cgctatatta 57180
aagcttatat tttgctggat tactgctaaa tacaaaagaa agttcaatat gttttcattt 57240
ctgtagggaa aatgggattg ctgctttaaa tttctgagct agggattttt tggcagctgc 57300
agtgttggcg actattgtaa aattctcttt gtttctctct gtaaatagca cctgctaaca 57360
ttacaatttg tatttatgtt taaagaaggc atcatttggt gaacagaact aggaaatgaa 57420
tttttagctc ttaaaagcat ttgctttgag accgcacagg agtgtctttc cttgtaaaac 57480
agtgatgata atttctgcct tggccctacc ttgaagcaat gttgtgtgaa gggatgaaga 57540
atctaaaagt cttcataagt ccttgggaga ggtgctagaa aaatataagg cactatcata 57600
attacagtga tgtccttgct gttactactc aaatcaccca caaatttccc caaagactgc 57660
gctagctgtc aaataaaaga cagtgaaatt gacctga 57697
<210> 110
<211> 4654
<212> DNA
<213> Homo sapiens
<400> 110
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg 60
ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta 120
cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg 180
ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg 240
tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc 300
cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt 360
ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg 420
ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag 480
gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc 540
gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa 600
cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg 660
gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct 720
tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct 780
ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga 840
aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga 900
cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct 960
atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca 1020
cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca 1080
gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc 1140
ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc 1200
caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg 1260
gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg 1320
acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc 1380
acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa 1440
atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc 1500
agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg 1560
ggctgcccta cctcaaggtt ctcaaggccg ccggtgttaa caccacggac aaagagattg 1620
aggttctcta tattcggaat gtaacttttg aggacgctgg ggaatatacg tgcttggcgg 1680
gtaattctat tgggatatcc tttcactctg catggttgac agttctgcca gcgcctggaa 1740
gagaaaagga gattacagct tccccagact acctggagat agccatttac tgcatagggg 1800
tcttcttaat cgcctgtatg gtggtaacag tcatcctgtg ccgaatgaag aacacgacca 1860
agaagccaga cttcagcagc cagccggctg tgcacaagct gaccaaacgt atccccctgc 1920
ggagacaggt aacagtttcg gctgagtcca gctcctccat gaactccaac accccgctgg 1980
tgaggataac aacacgcctc tcttcaacgg cagacacccc catgctggca ggggtctccg 2040
agtatgaact tccagaggac ccaaaatggg agtttccaag agataagctg acactgggca 2100
agcccctggg agaaggttgc tttgggcaag tggtcatggc ggaagcagtg ggaattgaca 2160
aagacaagcc caaggaggcg gtcaccgtgg ccgtgaagat gttgaaagat gatgccacag 2220
agaaagacct ttctgatctg gtgtcagaga tggagatgat gaagatgatt gggaaacaca 2280
agaatatcat aaatcttctt ggagcctgca cacaggatgg gcctctctat gtcatagttg 2340
agtatgcctc taaaggcaac ctccgagaat acctccgagc ccggaggcca cccgggatgg 2400
agtactccta tgacattaac cgtgttcctg aggagcagat gaccttcaag gacttggtgt 2460
catgcaccta ccagctggcc agaggcatgg agtacttggc ttcccaaaaa tgtattcatc 2520
gagatttagc agccagaaat gttttggtaa cagaaaacaa tgtgatgaaa atagcagact 2580
ttggactcgc cagagatatc aacaatatag actattacaa aaagaccacc aatgggcggc 2640
ttccagtcaa gtggatggct ccagaagccc tgtttgatag agtatacact catcagagtg 2700
atgtctggtc cttcggggtg ttaatgtggg agatcttcac tttagggggc tcgccctacc 2760
cagggattcc cgtggaggaa ctttttaagc tgctgaagga aggacacaga atggataagc 2820
cagccaactg caccaacgaa ctgtacatga tgatgaggga ctgttggcat gcagtgccct 2880
cccagagacc aacgttcaag cagttggtag aagacttgga tcgaattctc actctcacaa 2940
ccaatgagga atacttggac ctcagccaac ctctcgaaca gtattcacct agttaccctg 3000
acacaagaag ttcttgttct tcaggagatg attctgtttt ttctccagac cccatgcctt 3060
acgaaccatg ccttcctcag tatccacaca taaacggcag tgttaaaaca tgaatgactg 3120
tgtctgcctg tccccaaaca ggacagcact gggaacctag ctacactgag cagggagacc 3180
atgcctccca gagcttgttg tctccacttg tatatatgga tcagaggagt aaataattgg 3240
aaaagtaatc agcatatgtg taaagattta tacagttgaa aacttgtaat cttccccagg 3300
aggagaagaa ggtttctgga gcagtggact gccacaagcc accatgtaac ccctctcacc 3360
tgccgtgcgt actggctgtg gaccagtagg actcaaggtg gacgtgcgtt ctgccttcct 3420
tgttaatttt gtaataattg gagaagattt atgtcagcac acacttacag agcacaaatg 3480
cagtatatag gtgctggatg tatgtaaata tattcaaatt atgtataaat atatattata 3540
tatttacaag gagttatttt ttgtattgat tttaaatgga tgtcccaatg cacctagaaa 3600
attggtctct ctttttttaa tagctatttg ctaaatgctg ttcttacaca taatttctta 3660
attttcaccg agcagaggtg gaaaaatact tttgctttca gggaaaatgg tataacgtta 3720
atttattaat aaattggtaa tatacaaaac aattaatcat ttatagtttt ttttgtaatt 3780
taagtggcat ttctatgcag gcagcacagc agactagtta atctattgct tggacttaac 3840
tagttatcag atcctttgaa aagagaatat ttacaatata tgactaattt ggggaaaatg 3900
aagttttgat ttatttgtgt ttaaatgctg ctgtcagacg attgttctta gacctcctaa 3960
atgccccata ttaaaagaac tcattcatag gaaggtgttt cattttggtg tgcaaccctg 4020
tcattacgtc aacgcaacgt ctaactggac ttcccaagat aaatggtacc agcgtcctct 4080
taaaagatgc cttaatccat tccttgagga cagaccttag ttgaaatgat agcagaatgt 4140
gcttctctct ggcagctggc cttctgcttc tgagttgcac attaatcaga ttagcctgta 4200
ttctcttcag tgaattttga taatggcttc cagactcttt ggcgttggag acgcctgtta 4260
ggatcttcaa gtcccatcat agaaaattga aacacagagt tgttctgctg atagttttgg 4320
ggatacgtcc atctttttaa gggattgctt tcatctaatt ctggcaggac ctcaccaaaa 4380
gatccagcct catacctaca tcagacaaaa tatcgccgtt gttccttctg tactaaagta 4440
ttgtgttttg ctttggaaac acccactcac tttgcaatag ccgtgcaaga tgaatgcaga 4500
ttacactgat cttatgtgtt acaaaattgg agaaagtatt taataaaacc tgttaatttt 4560
tatactgaca ataaaaatgt ttctacagat attaatgtta acaagacaaa ataaatgtca 4620
cgcaacttat ttttttaata aaaaaaaaaa aaaa 4654
<210> 111
<211> 2781
<212> DNA
<213> Homo sapiens
<400> 111
tgactgcagc agcagcggca gcgcctcggt tcctgagccc accgcaggct gaaggcattg 60
cgcgtagtcc atgcccgtag aggaagtgtg cagatgggat taacgtccac atggagatat 120
ggaagaggac cggggattgg taccgtaacc atggtcagct ggggtcgttt catctgcctg 180
gtcgtggtca ccatggcaac cttgtccctg gcccggccct ccttcagttt agttgaggat 240
accacattag agccagaaga gccaccaacc aaataccaaa tctctcaacc agaagtgtac 300
gtggctgcgc caggggagtc gctagaggtg cgctgcctgt tgaaagatgc cgccgtgatc 360
agttggacta aggatggggt gcacttgggg cccaacaata ggacagtgct tattggggag 420
tacttgcaga taaagggcgc cacgcctaga gactccggcc tctatgcttg tactgccagt 480
aggactgtag acagtgaaac ttggtacttc atggtgaatg tcacagatgc catctcatcc 540
ggagatgatg aggatgacac cgatggtgcg gaagattttg tcagtgagaa cagtaacaac 600
aagagagcac catactggac caacacagaa aagatggaaa agcggctcca tgctgtgcct 660
gcggccaaca ctgtcaagtt tcgctgccca gccgggggga acccaatgcc aaccatgcgg 720
tggctgaaaa acgggaagga gtttaagcag gagcatcgca ttggaggcta caaggtacga 780
aaccagcact ggagcctcat tatggaaagt gtggtcccat ctgacaaggg aaattatacc 840
tgtgtagtgg agaatgaata cgggtccatc aatcacacgt accacctgga tgttgtggag 900
cgatcgcctc accggcccat cctccaagcc ggactgccgg caaatgcctc cacagtggtc 960
ggaggagacg tagagtttgt ctgcaaggtt tacagtgatg cccagcccca catccagtgg 1020
atcaagcacg tggaaaagaa cggcagtaaa tacgggcccg acgggctgcc ctacctcaag 1080
gttctcaagc actcggggat aaatagttcc aatgcagaag tgctggctct gttcaatgtg 1140
accgaggcgg atgctgggga atatatatgt aaggtctcca attatatagg gcaggccaac 1200
cagtctgcct ggctcactgt cctgccaaaa cagcaagcgc ctggaagaga aaaggagatt 1260
acagcttccc cagactacct ggagatagcc atttactgca taggggtctt cttaatcgcc 1320
tgtatggtgg taacagtcat cctgtgccga atgaagaaca cgaccaagaa gccagacttc 1380
agcagccagc cggctgtgca caagctgacc aaacgtatcc ccctgcggag acaggtaaca 1440
gtttcggctg agtccagctc ctccatgaac tccaacaccc cgctggtgag gataacaaca 1500
cgcctctctt caacggcaga cacccccatg ctggcagggg tctccgagta tgaacttcca 1560
gaggacccaa aatgggagtt tccaagagat aagctgacac tgggcaagcc cctgggagaa 1620
ggttgctttg ggcaagtggt catggcggaa gcagtgggaa ttgacaaaga caagcccaag 1680
gaggcggtca ccgtggccgt gaagatgttg aaagatgatg ccacagagaa agacctttct 1740
gatctggtgt cagagatgga gatgatgaag atgattggga aacacaagaa tatcataaat 1800
cttcttggag cctgcacaca ggatgggcct ctctatgtca tagttgagta tgcctctaaa 1860
ggcaacctcc gagaatacct ccgagcccgg aggccacccg ggatggagta ctcctatgac 1920
attaaccgtg ttcctgagga gcagatgacc ttcaaggact tggtgtcatg cacctaccag 1980
ctggccagag gcatggagta cttggcttcc caaaaatgta ttcatcgaga tttagcagcc 2040
agaaatgttt tggtaacaga aaacaatgtg atgaaaatag cagactttgg actcgccaga 2100
gatatcaaca atatagacta ttacaaaaag accaccaatg ggcggcttcc agtcaagtgg 2160
atggctccag aagccctgtt tgatagagta tacactcatc agagtgatgt ctggtccttc 2220
ggggtgttaa tgtgggagat cttcacttta gggggctcgc cctacccagg gattcccgtg 2280
gaggaacttt ttaagctgct gaaggaagga cacagaatgg ataagccagc caactgcacc 2340
aacgaactgt acatgatgat gagggactgt tggcatgcag tgccctccca gagaccaacg 2400
ttcaagcagt tggtagaaga cttggatcga attctcactc tcacaaccaa tgagatctga 2460
aagtttatgg cttcattgag aaactgggaa aagttggtca ggcgcagtgg ctcatgcctg 2520
taatcccagc actttgggag gccgaggcag gcggatcatg aggtcaggag ttccagacca 2580
gcctggccaa catggtgaaa ccctgtctct actaaagata caaaaaatta gccgggcgtg 2640
ttggtgtgca cctgtaatcc cagctactcc gggaggctga ggcaggagag tcacttgaac 2700
cggggaggcg gaggttgcag tgagccgaga tcatgccatt gcattccagc cttggcgaca 2760
gagcgagact ccgtctcaaa a 2781
<210> 112
<211> 3821
<212> DNA
<213> Homo sapiens
<400> 112
tgactgcagc agcagcggca gcgcctcggt tcctgagccc accgcaggct gaaggcattg 60
cgcgtagtcc atgcccgtag aggaagtgtg cagatgggat taacgtccac atggagatat 120
ggaagaggac cggggattgg taccgtaacc atggtcagct ggggtcgttt catctgcctg 180
gtcgtggtca ccatggcaac cttgtccctg gcccggccct ccttcagttt agttgaggat 240
accacattag agccagaaga gccaccaacc aaataccaaa tctctcaacc agaagtgtac 300
gtggctgcgc caggggagtc gctagaggtg cgctgcctgt tgaaagatgc cgccgtgatc 360
agttggacta aggatggggt gcacttgggg cccaacaata ggacagtgct tattggggag 420
tacttgcaga taaagggcgc cacgcctaga gactccggcc tctatgcttg tactgccagt 480
aggactgtag acagtgaaac ttggtacttc atggtgaatg tcacagatgc catctcatcc 540
ggagatgatg aggatgacac cgatggtgcg gaagattttg tcagtgagaa cagtaacaac 600
aagagagcac catactggac caacacagaa aagatggaaa agcggctcca tgctgtgcct 660
gcggccaaca ctgtcaagtt tcgctgccca gccgggggga acccaatgcc aaccatgcgg 720
tggctgaaaa acgggaagga gtttaagcag gagcatcgca ttggaggcta caaggtacga 780
aaccagcact ggagcctcat tatggaaagt gtggtcccat ctgacaaggg aaattatacc 840
tgtgtagtgg agaatgaata cgggtccatc aatcacacgt accacctgga tgttgtggcg 900
cctggaagag aaaaggagat tacagcttcc ccagactacc tggagatagc catttactgc 960
ataggggtct tcttaatcgc ctgtatggtg gtaacagtca tcctgtgccg aatgaagaac 1020
acgaccaaga agccagactt cagcagccag ccggctgtgc acaagctgac caaacgtatc 1080
cccctgcgga gacaggtaac agtttcggct gagtccagct cctccatgaa ctccaacacc 1140
ccgctggtga ggataacaac acgcctctct tcaacggcag acacccccat gctggcaggg 1200
gtctccgagt atgaacttcc agaggaccca aaatgggagt ttccaagaga taagctgaca 1260
ctgggcaagc ccctgggaga aggttgcttt gggcaagtgg tcatggcgga agcagtggga 1320
attgacaaag acaagcccaa ggaggcggtc accgtggccg tgaagatgtt gaaagatgat 1380
gccacagaga aagacctttc tgatctggtg tcagagatgg agatgatgaa gatgattggg 1440
aaacacaaga atatcataaa tcttcttgga gcctgcacac aggatgggcc tctctatgtc 1500
atagttgagt atgcctctaa aggcaacctc cgagaatacc tccgagcccg gaggccaccc 1560
gggatggagt actcctatga cattaaccgt gttcctgagg agcagatgac cttcaaggac 1620
ttggtgtcat gcacctacca gctggccaga ggcatggagt acttggcttc ccaaaaatgt 1680
attcatcgag atttagcagc cagaaatgtt ttggtaacag aaaacaatgt gatgaaaata 1740
gcagactttg gactcgccag agatatcaac aatatagact attacaaaaa gaccaccaat 1800
gggcggcttc cagtcaagtg gatggctcca gaagccctgt ttgatagagt atacactcat 1860
cagagtgatg tctggtcctt cggggtgtta atgtgggaga tcttcacttt agggggctcg 1920
ccctacccag ggattcccgt ggaggaactt tttaagctgc tgaaggaagg acacagaatg 1980
gataagccag ccaactgcac caacgaactg tacatgatga tgagggactg ttggcatgca 2040
gtgccctccc agagaccaac gttcaagcag ttggtagaag acttggatcg aattctcact 2100
ctcacaacca atgaggaata cttggacctc agccaacctc tcgaacagta ttcacctagt 2160
taccctgaca caagaagttc ttgttcttca ggagatgatt ctgttttttc tccagacccc 2220
atgccttacg aaccatgcct tcctcagtat ccacacataa acggcagtgt taaaacatga 2280
atgactgtgt ctgcctgtcc ccaaacagga cagcactggg aacctagcta cactgagcag 2340
ggagaccatg cctcccagag cttgttgtct ccacttgtat atatggatca gaggagtaaa 2400
taattggaaa agtaatcagc atatgtgtaa agatttatac agttgaaaac ttgtaatctt 2460
ccccaggagg agaagaaggt ttctggagca gtggactgcc acaagccacc atgtaacccc 2520
tctcacctgc cgtgcgtact ggctgtggac cagtaggact caaggtggac gtgcgttctg 2580
ccttccttgt taattttgta ataattggag aagatttatg tcagcacaca cttacagagc 2640
acaaatgcag tatataggtg ctggatgtat gtaaatatat tcaaattatg tataaatata 2700
tattatatat ttacaaggag ttattttttg tattgatttt aaatggatgt cccaatgcac 2760
ctagaaaatt ggtctctctt tttttaatag ctatttgcta aatgctgttc ttacacataa 2820
tttcttaatt ttcaccgagc agaggtggaa aaatactttt gctttcaggg aaaatggtat 2880
aacgttaatt tattaataaa ttggtaatat acaaaacaat taatcattta tagttttttt 2940
tgtaatttaa gtggcatttc tatgcaggca gcacagcaga ctagttaatc tattgcttgg 3000
acttaactag ttatcagatc ctttgaaaag agaatattta caatatatga ctaatttggg 3060
gaaaatgaag ttttgattta tttgtgttta aatgctgctg tcagacgatt gttcttagac 3120
ctcctaaatg ccccatatta aaagaactca ttcataggaa ggtgtttcat tttggtgtgc 3180
aaccctgtca ttacgtcaac gcaacgtcta actggacttc ccaagataaa tggtaccagc 3240
gtcctcttaa aagatgcctt aatccattcc ttgaggacag accttagttg aaatgatagc 3300
agaatgtgct tctctctggc agctggcctt ctgcttctga gttgcacatt aatcagatta 3360
gcctgtattc tcttcagtga attttgataa tggcttccag actctttggc gttggagacg 3420
cctgttagga tcttcaagtc ccatcataga aaattgaaac acagagttgt tctgctgata 3480
gttttgggga tacgtccatc tttttaaggg attgctttca tctaattctg gcaggacctc 3540
accaaaagat ccagcctcat acctacatca gacaaaatat cgccgttgtt ccttctgtac 3600
taaagtattg tgttttgctt tggaaacacc cactcacttt gcaatagccg tgcaagatga 3660
atgcagatta cactgatctt atgtgttaca aaattggaga aagtatttaa taaaacctgt 3720
taatttttat actgacaata aaaatgtttc tacagatatt aatgttaaca agacaaaata 3780
aatgtcacgc aacttatttt tttaataaaa aaaaaaaaaa a 3821
<210> 113
<211> 3708
<212> DNA
<213> Homo sapiens
<400> 113
aatttgttga ggaatttccc cctagccttg accccttgac agctcccgct cctactcagt 60
gctggggaga agtagggagg ccttaagcga agagatgggt ctgcactttg gaggagccgg 120
acactgttga ctttcctgat gtgaaatcta cccaggaaca aaacaccagt gactgcagca 180
gcagcggcag cgcctcggtt cctgagccca ccgcaggctg aaggcattgc gcgtagtcca 240
tgcccgtaga ggaagtgtgc agatgggatt aacgtccaca tggagatatg gaagaggacc 300
ggggattggt accgtaacca tggtcagctg gggtcgtttc atctgcctgg tcgtggtcac 360
catggcaacc ttgtccctgg cccggccctc cttcagttta gttgaggata ccacattaga 420
gccagaagat gccatctcat ccggagatga tgaggatgac accgatggtg cggaagattt 480
tgtcagtgag aacagtaaca acaagagagc accatactgg accaacacag aaaagatgga 540
aaagcggctc catgctgtgc ctgcggccaa cactgtcaag tttcgctgcc cagccggggg 600
gaacccaatg ccaaccatgc ggtggctgaa aaacgggaag gagtttaagc aggagcatcg 660
cattggaggc tacaaggtac gaaaccagca ctggagcctc attatggaaa gtgtggtccc 720
atctgacaag ggaaattata cctgtgtagt ggagaatgaa tacgggtcca tcaatcacac 780
gtaccacctg gatgttgtgg agcgatcgcc tcaccggccc atcctccaag ccggactgcc 840
ggcaaatgcc tccacagtgg tcggaggaga cgtagagttt gtctgcaagg tttacagtga 900
tgcccagccc cacatccagt ggatcaagca cgtggaaaag aacggcagta aatacgggcc 960
cgacgggctg ccctacctca aggttctcaa ggccgccggt gttaacacca cggacaaaga 1020
gattgaggtt ctctatattc ggaatgtaac ttttgaggac gctggggaat atacgtgctt 1080
ggcgggtaat tctattggga tatcctttca ctctgcatgg ttgacagttc tgccagcgcc 1140
tggaagagaa aaggagatta cagcttcccc agactacctg gagatagcca tttactgcat 1200
aggggtcttc ttaatcgcct gtatggtggt aacagtcatc ctgtgccgaa tgaagaacac 1260
gaccaagaag ccagacttca gcagccagcc ggctgtgcac aagctgacca aacgtatccc 1320
cctgcggaga caggtaacag tttcggctga gtccagctcc tccatgaact ccaacacccc 1380
gctggtgagg ataacaacac gcctctcttc aacggcagac acccccatgc tggcaggggt 1440
ctccgagtat gaacttccag aggacccaaa atgggagttt ccaagagata agctgacact 1500
gggcaagccc ctgggagaag gttgctttgg gcaagtggtc atggcggaag cagtgggaat 1560
tgacaaagac aagcccaagg aggcggtcac cgtggccgtg aagatgttga aagatgatgc 1620
cacagagaaa gacctttctg atctggtgtc agagatggag atgatgaaga tgattgggaa 1680
acacaagaat atcataaatc ttcttggagc ctgcacacag gatgggcctc tctatgtcat 1740
agttgagtat gcctctaaag gcaacctccg agaatacctc cgagcccgga ggccacccgg 1800
gatggagtac tcctatgaca ttaaccgtgt tcctgaggag cagatgacct tcaaggactt 1860
ggtgtcatgc acctaccagc tggccagagg catggagtac ttggcttccc aaaaatgtat 1920
tcatcgagat ttagcagcca gaaatgtttt ggtaacagaa aacaatgtga tgaaaatagc 1980
agactttgga ctcgccagag atatcaacaa tatagactat tacaaaaaga ccaccaatgg 2040
gcggcttcca gtcaagtgga tggctccaga agccctgttt gatagagtat acactcatca 2100
gagtgatgtc tggtccttcg gggtgttaat gtgggagatc ttcactttag ggggctcgcc 2160
ctacccaggg attcccgtgg aggaactttt taagctgctg aaggaaggac acagaatgga 2220
taagccagcc aactgcacca acgaactgta catgatgatg agggactgtt ggcatgcagt 2280
gccctcccag agaccaacgt tcaagcagtt ggtagaagac ttggatcgaa ttctcactct 2340
cacaaccaat gaggaggaga agaaggtttc tggagcagtg gactgccaca agccaccatg 2400
taacccctct cacctgccgt gcgtactggc tgtggaccag taggactcaa ggtggacgtg 2460
cgttctgcct tccttgttaa ttttgtaata attggagaag atttatgtca gcacacactt 2520
acagagcaca aatgcagtat ataggtgctg gatgtatgta aatatattca aattatgtat 2580
aaatatatat tatatattta caaggagtta ttttttgtat tgattttaaa tggatgtccc 2640
aatgcaccta gaaaattggt ctctcttttt ttaatagcta tttgctaaat gctgttctta 2700
cacataattt cttaattttc accgagcaga ggtggaaaaa tacttttgct ttcagggaaa 2760
atggtataac gttaatttat taataaattg gtaatataca aaacaattaa tcatttatag 2820
ttttttttgt aatttaagtg gcatttctat gcaggcagca cagcagacta gttaatctat 2880
tgcttggact taactagtta tcagatcctt tgaaaagaga atatttacaa tatatgacta 2940
atttggggaa aatgaagttt tgatttattt gtgtttaaat gctgctgtca gacgattgtt 3000
cttagacctc ctaaatgccc catattaaaa gaactcattc ataggaaggt gtttcatttt 3060
ggtgtgcaac cctgtcatta cgtcaacgca acgtctaact ggacttccca agataaatgg 3120
taccagcgtc ctcttaaaag atgccttaat ccattccttg aggacagacc ttagttgaaa 3180
tgatagcaga atgtgcttct ctctggcagc tggccttctg cttctgagtt gcacattaat 3240
cagattagcc tgtattctct tcagtgaatt ttgataatgg cttccagact ctttggcgtt 3300
ggagacgcct gttaggatct tcaagtccca tcatagaaaa ttgaaacaca gagttgttct 3360
gctgatagtt ttggggatac gtccatcttt ttaagggatt gctttcatct aattctggca 3420
ggacctcacc aaaagatcca gcctcatacc tacatcagac aaaatatcgc cgttgttcct 3480
tctgtactaa agtattgtgt tttgctttgg aaacacccac tcactttgca atagccgtgc 3540
aagatgaatg cagattacac tgatcttatg tgttacaaaa ttggagaaag tatttaataa 3600
aacctgttaa tttttatact gacaataaaa atgtttctac agatattaat gttaacaaga 3660
caaaataaat gtcacgcaac ttattttttt aataaaaaaa aaaaaaaa 3708
<210> 114
<211> 4103
<212> DNA
<213> Homo sapiens
<400> 114
gagcacacat tgcctcactg aagtggctgc acgtatctga gtcctgtagc tactgtttta 60
tctctgtttc ttaaaagtat gcttttaaaa agattagcct cacacatttc tgtggaccgg 120
tctggtggta tcacctggga ctctgaggtg aggatggaag gatttagcag ataatgaaaa 180
agaactctgt ttgcgcacat ttgagaggct gaaaaatggt tttatcccac ttgggctgga 240
gtgatttggc attggggaag attccctgac tcgccaatct ctttccttta gtgactgcag 300
cagcagcggc agcgcctcgg ttcctgagcc caccgcaggc tgaaggcatt gcgcgtagtc 360
catgcccgta gaggaagtgt gcagatggga ttaacgtcca catggagata tggaagagga 420
ccggggattg gtaccgtaac catggtcagc tggggtcgtt tcatctgcct ggtcgtggtc 480
accatggcaa ccttgtccct ggcccggccc tccttcagtt tagttgagga taccacatta 540
gagccagaag gagcaccata ctggaccaac acagaaaaga tggaaaagcg gctccatgct 600
gtgcctgcgg ccaacactgt caagtttcgc tgcccagccg gggggaaccc aatgccaacc 660
atgcggtggc tgaaaaacgg gaaggagttt aagcaggagc atcgcattgg aggctacaag 720
gtacgaaacc agcactggag cctcattatg gaaagtgtgg tcccatctga caagggaaat 780
tatacctgtg tagtggagaa tgaatacggg tccatcaatc acacgtacca cctggatgtt 840
gtggagcgat cgcctcaccg gcccatcctc caagccggac tgccggcaaa tgcctccaca 900
gtggtcggag gagacgtaga gtttgtctgc aaggtttaca gtgatgccca gccccacatc 960
cagtggatca agcacgtgga aaagaacggc agtaaatacg ggcccgacgg gctgccctac 1020
ctcaaggttc tcaaggccgc cggtgttaac accacggaca aagagattga ggttctctat 1080
attcggaatg taacttttga ggacgctggg gaatatacgt gcttggcggg taattctatt 1140
gggatatcct ttcactctgc atggttgaca gttctgccag cgcctggaag agaaaaggag 1200
attacagctt ccccagacta cctggagata gccatttact gcataggggt cttcttaatc 1260
gcctgtatgg tggtaacagt catcctgtgc cgaatgaaga acacgaccaa gaagccagac 1320
ttcagcagcc agccggctgt gcacaagctg accaaacgta tccccctgcg gagacaggta 1380
acagtttcgg ctgagtccag ctcctccatg aactccaaca ccccgctggt gaggataaca 1440
acacgcctct cttcaacggc agacaccccc atgctggcag gggtctccga gtatgaactt 1500
ccagaggacc caaaatggga gtttccaaga gataagctga cactgggcaa gcccctggga 1560
gaaggttgct ttgggcaagt ggtcatggcg gaagcagtgg gaattgacaa agacaagccc 1620
aaggaggcgg tcaccgtggc cgtgaagatg ttgaaagatg atgccacaga gaaagacctt 1680
tctgatctgg tgtcagagat ggagatgatg aagatgattg ggaaacacaa gaatatcata 1740
aatcttcttg gagcctgcac acaggatggg cctctctatg tcatagttga gtatgcctct 1800
aaaggcaacc tccgagaata cctccgagcc cggaggccac ccgggatgga gtactcctat 1860
gacattaacc gtgttcctga ggagcagatg accttcaagg acttggtgtc atgcacctac 1920
cagctggcca gaggcatgga gtacttggct tcccaaaaat gtattcatcg agatttagca 1980
gccagaaatg ttttggtaac agaaaacaat gtgatgaaaa tagcagactt tggactcgcc 2040
agagatatca acaatataga ctattacaaa aagaccacca atgggcggct tccagtcaag 2100
tggatggctc cagaagccct gtttgataga gtatacactc atcagagtga tgtctggtcc 2160
ttcggggtgt taatgtggga gatcttcact ttagggggct cgccctaccc agggattccc 2220
gtggaggaac tttttaagct gctgaaggaa ggacacagaa tggataagcc agccaactgc 2280
accaacgaac tgtacatgat gatgagggac tgttggcatg cagtgccctc ccagagacca 2340
acgttcaagc agttggtaga agacttggat cgaattctca ctctcacaac caatgaggaa 2400
tacttggacc tcagccaacc tctcgaacag tattcaccta gttaccctga cacaagaagt 2460
tcttgttctt caggagatga ttctgttttt tctccagacc ccatgcctta cgaaccatgc 2520
cttcctcagt atccacacat aaacggcagt gttaaaacat gaatgactgt gtctgcctgt 2580
ccccaaacag gacagcactg ggaacctagc tacactgagc agggagacca tgcctcccag 2640
agcttgttgt ctccacttgt atatatggat cagaggagta aataattgga aaagtaatca 2700
gcatatgtgt aaagatttat acagttgaaa acttgtaatc ttccccagga ggagaagaag 2760
gtttctggag cagtggactg ccacaagcca ccatgtaacc cctctcacct gccgtgcgta 2820
ctggctgtgg accagtagga ctcaaggtgg acgtgcgttc tgccttcctt gttaattttg 2880
taataattgg agaagattta tgtcagcaca cacttacaga gcacaaatgc agtatatagg 2940
tgctggatgt atgtaaatat attcaaatta tgtataaata tatattatat atttacaagg 3000
agttattttt tgtattgatt ttaaatggat gtcccaatgc acctagaaaa ttggtctctc 3060
tttttttaat agctatttgc taaatgctgt tcttacacat aatttcttaa ttttcaccga 3120
gcagaggtgg aaaaatactt ttgctttcag ggaaaatggt ataacgttaa tttattaata 3180
aattggtaat atacaaaaca attaatcatt tatagttttt tttgtaattt aagtggcatt 3240
tctatgcagg cagcacagca gactagttaa tctattgctt ggacttaact agttatcaga 3300
tcctttgaaa agagaatatt tacaatatat gactaatttg gggaaaatga agttttgatt 3360
tatttgtgtt taaatgctgc tgtcagacga ttgttcttag acctcctaaa tgccccatat 3420
taaaagaact cattcatagg aaggtgtttc attttggtgt gcaaccctgt cattacgtca 3480
acgcaacgtc taactggact tcccaagata aatggtacca gcgtcctctt aaaagatgcc 3540
ttaatccatt ccttgaggac agaccttagt tgaaatgata gcagaatgtg cttctctctg 3600
gcagctggcc ttctgcttct gagttgcaca ttaatcagat tagcctgtat tctcttcagt 3660
gaattttgat aatggcttcc agactctttg gcgttggaga cgcctgttag gatcttcaag 3720
tcccatcata gaaaattgaa acacagagtt gttctgctga tagttttggg gatacgtcca 3780
tctttttaag ggattgcttt catctaattc tggcaggacc tcaccaaaag atccagcctc 3840
atacctacat cagacaaaat atcgccgttg ttccttctgt actaaagtat tgtgttttgc 3900
tttggaaaca cccactcact ttgcaatagc cgtgcaagat gaatgcagat tacactgatc 3960
ttatgtgtta caaaattgga gaaagtattt aataaaacct gttaattttt atactgacaa 4020
taaaaatgtt tctacagata ttaatgttaa caagacaaaa taaatgtcac gcaacttatt 4080
tttttaataa aaaaaaaaaa aaa 4103
<210> 115
<211> 57697
<212> DNA
<213> Homo sapiens
<400> 115
agatgcaggg gcgcaaacgc caaaggagac caggctgtag gaagagaagg gcagagcgcc 60
ggacagctcg gcccgctccc cgtcctttgg ggccgcggct ggggaactac aaggcccagc 120
aggcagctgc agggggcgga ggcggaggag ggaccagcgc gggtgggagt gagagagcga 180
gccctcgcgc cccgccggcg catagcgctc ggagcgctct tgcggccaca ggcgcggcgt 240
cctcggcggc gggcggcagc tagcgggagc cgggacgccg gtgcagccgc agcgcgcgga 300
ggaacccggg tgtgccggga gctgggcggc cacgtccgga cgggaccgag acccctcgta 360
gcgcattgcg gcgacctcgc cttccccggc cgcgagcgcg ccgctgcttg aaaagccgcg 420
gaacccaagg acttttctcc ggtccgagct cggggcgccc cgcagggcgc acggtacccg 480
tgctgcagtc gggcacgccg cggcgccggg gcctccgcag ggcgatggag cccggtctgc 540
aaggaaagtg aggcgccgcc gctgcgttct ggaggagggg ggcacaaggt ctggagaccc 600
cgggtggcgg acgggagccc tccccccgcc ccgcctccgg ggcaccagct ccggctccat 660
tgttcccgcc cgggctggag gcgccgagca ccgagcgccg ccgggagtcg agcgccggcc 720
gcggagctct tgcgaccccg ccaggacccg aacagagccc gggggcggcg ggccggagcc 780
ggggacgcgg gcacacgccc gctcgcacaa gccacggcgg actctcccga ggcggaacct 840
ccacgccgag cgaggtaaga gccgcggcgc ccccggatct ggggcgggct tggcgtcccg 900
agcggccccc ggcgccggag cctcccggct gcgcgctttg cccgccgcag cccagccggg 960
gccggcgcct ccctccgctc gccgcccgcc cctttcacct cctggctccc tcccgggcga 1020
tccgcgcccc ttgggtctcc cctcccttcc ctccgtccgc gtctcctgcg ccccctccct 1080
gcgctcgtcc cgccgctctt cccgccgccc aacttttcct ccaactcgcg ctcgggagct 1140
ggcgaggcgg cggcggctcc tcagtgagtc ccgggaggga caggcccggg gcgaaggcgg 1200
cgaggcccgc ggtttcctgg actggggagg agggcgggag tgggcggcga ggtgggatgc 1260
gttgtgtgtg ttatgtgtgt gtgttgcatt ccactccatg tctttttggt ccccttttgg 1320
ggattcaccc ccaattcagc aggtagcttt gggctcaacg ctaaaaatcc ggggcattcc 1380
taagtccttt tccacccccg ggaaagcctg gggtgcgggt tggggtcgga tggggtggga 1440
gatgaactgc ggaggacgtg gagggctagg ttagcttctc ttggaatagg ttttaaggag 1500
gtgtcgtcac caaatggctg aatctgcttg agctgagagc gaaaaacgac tcccctttcc 1560
agaaggggtg atcttatgac ttggacggtc tctgaaaggg tcggaagttt ggggaacggg 1620
aggacaaccc acggtcgtta agccgaggtg tgggatgggg gcggaaggac cgttcggtcc 1680
caatctggtt cctagaggtg ggggaaggga tgagggtttt tgtccggtgt ggttcactcg 1740
gcagcgatgc gtatgcttct ctggcccaga cccctctgca cctcgcttcc cctaccgtta 1800
tgtttggggt tgggagaaaa gtgaggctac gacccatgtt tgcggaggaa ttttatggac 1860
cttgtagatg ggggttcata tagaacacac accccctatg aggcagccag acactttttt 1920
ggtggtggtg gggggggggt ggggtgtgaa gcctgtttct tgttctgagc ccagaagcta 1980
tcaacccttt tgaaaaacat taccacggtg cctttctccc ccagcactcc cccaccccca 2040
atttccagat gtagcagccg catctggttc cgtttcaccc cacacgggta caccgcagcc 2100
gcattattaa cttccctctt cctcccctcc ccctccccca aattaaaact cagattcttc 2160
agcctgtctt gaccacctcc ctccttaaca tttctggaga cttggagatg cggcgttgag 2220
attcggggga gaaaagaaag ttcccttgga tcccgagtta tttaagatct caccaagtta 2280
ttcgccgccg ctggtgggtg gcggcggtcc gggtgctttc tggattgcgc agtaaagagg 2340
catcttggga gatggggcca aggttttagg gggtgccact cgcgaacggt tcatccgcta 2400
gactaggggg gctctttggc tgtgcgtctg gccagaactg gccttgacga tggaagtttc 2460
tggaaccaaa gcgttgcttt ctctcccttg tgttatagct ggagctgcgg gagcgcctgc 2520
cctgcccgga gcccgcggtc ccctctcggc tgccccgcgg tggcgtcacg cgcccctccc 2580
ggagcaagcc cggtgcgcag ggccgggggc gtgggcggct gctgccagag gcgctctctg 2640
tgtgttttta aggactgatt tgggccgcat cccccggaaa ctaaagtggg gtgttttacc 2700
gtttaaataa cggctacagg tttgaaagcg gggttggatt ttcgagttgt gtttggtaat 2760
agtctttgag gcaggaaagc gccttgtggt ccaaagttgc cgggagggtg gggagagtcg 2820
gtgtcttacc cgcttctttc cagcctcttt caaattgaaa acacttctct ggtttccttc 2880
tttgggcggt agttttggag gctgtaatga aatcgcactt tctctagacg tggtaattaa 2940
ggtgactgtt tcctccgcag atgtgcccta ccctttgcac ctccggacca gcgctttttt 3000
tggaatacta tctagccttg agactgttta gcagaaagtg gccattttcc tcccttggcc 3060
cgggctcccg gtttcctccc tgaggcttgt ttaaaagcga agtagcaggg ccccgtggga 3120
cgcgccttgg tctgggtaat cacccccacg cccgggtcat ccaccttcct ctcggtgacc 3180
gaggttcagc agcctctgct attgccggcc gtctttgccg atggcctgcc tccctaatga 3240
cttgtttaca tatcctaccc ccagtgggtt aggagaagct ccggggctgc cccgaccctc 3300
cgagtgcagg gtgtttgggg accgggaggc tgctggggcc tgactccagc tgggagggtt 3360
atgaactgca tcagtgacga gctgcttgaa atatctgttg catttactct tagtcatagc 3420
tgagtgtcag ctttttaatg aggttcatcc agattgagag ccacttggac tgcgtacttc 3480
actgcctgct tttccaaaca tgcctgcaga aatgctcatt ttcgaggtat ttttcccaat 3540
gggaattcag gccagagtgg gcaccacttg aacaatctta gggtgcttct tttccttggc 3600
ctctggccat ggagggtgtt agacagttcc attaggtggc cctttgatag caagggaagc 3660
aaaggctcag gaagaaatgg agaagcgtcc cccactccct aggggcagag gattagatac 3720
atcggtgcat ccctcaggct gggctagctt tattcctggt ggactccaga gggcaagaaa 3780
attgaattga acactgggta ggcagattca agccttagag accaaggaaa atccatgggt 3840
tttgctttta gtggtgtgct ctttgttttc agtattgacc tgaaacaaga ctcctaaaat 3900
gagagatttg ctggtatgaa cttgggggtt tagcagccgg cttctacaaa ggcttttttc 3960
ttgccttcgt ttctaaagtg tctttcgtca aaatggctgt tagttataga acatcctagc 4020
aaagtttgag cctgttgctg ctggaggaaa aggagttaga attgattcaa atgtcttatt 4080
ctgaaagggc ctcacatcac ttgatagttt aatttcctcc tgggaaattt gtgtcttaca 4140
tttgtcttcc ccagagcttt gtaaaaggcc tgaacgcacc agggactagt gggagcccag 4200
atgcagagct ttagagaaga ttctggtgtt tccagagagg atgaaatgtc agacttgggc 4260
taggatattt gtttttcctc ctaaggttgc atctacttta aacagaaatt ctctcctcgc 4320
caccatttat ctctcccctg caatgaaaga aaccatgttt agggccctct cccccattta 4380
atagccctca catggatgaa ctatcccaag aatttggtgg ggttccactc atagtacatc 4440
ctgtcttcaa gagcaaggtt ttctagatta tgtgcagcag ttcgtgtttc acttgttgct 4500
tttttttttt tttttttttt ttgagatagt ctcgctctgt cgcccaggct ggagtgctgt 4560
ggcgctatct caggtcactg caacctccgc cttccggttg aagcgattct cctgccccag 4620
cctccctagt agctgggatt gcaagcatgc gccaccatgt ccggctaatt ttttgtgttt 4680
ttaatagaga tggtgtttca ccatgttggc caggctgggc ttgaactcct gacctcaagc 4740
aatccgctgg cctcggcctc ccaaaatgct gggattacag gtgtgagcca ttgtgcctga 4800
ccacttattg ctaatttttt atatgtctct tacttccaag gacatttaga cacttttttt 4860
ttttaaagag actcaaaaaa ttagcatttc cattggacca actaaaattt agcaagctga 4920
gctgagtaac tttctccata tgtttattaa gtacttgccc cctgccctct caacatgtga 4980
gtagagaatg gtcactttgg ggaagaaata agtcttattc tcatctgaag ggattaatgt 5040
tttggtgtta cttcctcaat tctgaagaac caagttgtcc agaaattttc tcagggttct 5100
ttggactaga gtttggctgg ttaacaaggg gtactaccta attgcttttc tctgatattc 5160
tcagcctctt tttctggagg agtatctctg tcagtttctt ttcatcagcc cttttttttc 5220
cttcattcac ttactcattc atccagttaa caaacatgtt ggcatctcct gtgtacatgc 5280
taggtgccga gggtgttagc aaaggttagg gaggcacaga ccctgttctg aaggagcctg 5340
cagtttcgtg gggagagaag agaatgaaga acataaataa caatcatata atatgaccta 5400
agtgctatgt gagaggggct agtaatgtgg tttgcaaatt tggaggaatg aaattctcca 5460
gctagaaggc ccaagaaagt cttatggaag aaacagcttc ttaaggtggg gttcagagaa 5520
aagggaaggg ctggcctgtt gcagaacaag gaatggcatg aagaaagtct tgcacagagg 5580
catggatgtt gcttcgagct gtggcgccct atagaaatag aacatgagca gctggtcaca 5640
gtggctcatg cctgtaatcc cagcactttg ggaggccaag gcaggcggat tgcttgagcc 5700
catgagatgg agatgagcct ggacaacatg gtgagaccct gtgtctacca aaaaatacac 5760
aaattagatg agtatgctcg tgcttactgg tagtcccggc tattcaggag gctgaggtgg 5820
gaggatcact tgagcctagg aggcagaggc tgcaataagc tgtgattgca ccactgcatt 5880
ccagcctggg ggacagagga agaccctgtt taaaaaaaaa aaaaaaaaaa aagccaggca 5940
cagtggctca tgcctgtaat cccagccctt tgggaggcca aggcaggtgg atcacctgag 6000
gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ctatttctac taaaaataaa 6060
aaaattagcc gggcttggtg gctcatgtct gtaatcccag ctacttggga ggcaggagaa 6120
tcgtttgaac ccgggaggcg gtggttgagc caagattgcg ccactgcaac tccagcctga 6180
gtgacagagc aagactccat ctcaaagaaa aaaagaaagg aagaaagaaa tataacatta 6240
taacatgagt tatgtatatg ttcagatttt ctagaagcca cattggaaat taagttaaaa 6300
gaaagaaata ggtaaaaaaa attttttttt ttgagacgga gtctcacttt gttgccaggc 6360
tggagtgcag tggcgcaatc tcggctcact gcaacctctg cctcccgggt tcaagcaatt 6420
ctcctgcctc agcctcctga gtagctggga ctacaggcgc gcgccactgc acgcagctaa 6480
tttttgtact tttagtagag acggggtttc accatgttgg ccaggatggt gtcgacctct 6540
tgacctcgtg atttgcccac ctcagcctcc caaagtgctg ggattacagg cgtgagccac 6600
cgcgcctggc caatatttgt tttttaatta acttgtttgt ttagatttta tttaatgtaa 6660
ctatatttcc aaaatattat catttgaaca tgtaatcaat atagaaatta ttgatgagat 6720
actttacatt tttttcataa caagttttta agatgcggtg tatacttttt acttatagca 6780
tatccgttag caccagccac atttcaagtg tgcagtggcc actgtgtggg ccacaggtct 6840
agaatataag acatgaagat ggagagtgag aaatgccttt ggaaaggttg gaagttcctg 6900
tccttctgct gccaattacc aaatctcctg agagtgctat taaggagtga ctcaaagcac 6960
tacacaaaga gaattataaa tatcttaata ttatatctga aatccaaatg cataattctt 7020
tacatttggt tggtacttta gagaggagag aatgggcaca gtcacccaca ccacccattt 7080
gagcctcata atcacctgtg atgtggcttc ctctaggtgg gaaaccgagg cttagaacgg 7140
ttaagtgact atcccagggt ggcaagatca taagtggaag ggtgtgaatt catactgtct 7200
ccagcggaca agaataaaaa gacccaggct gggtgtggtg gctcatgcct gtaatcccag 7260
cactttggga ggccactgta ggtggatctc ctgagcccag gagttcatta ccagcatggg 7320
caacatggtg agaccccatt tttattaaat atacagaaaa ttagcccagc ttctcgggag 7380
gctgaggtgg gaggatcact tgagtctggg ggatggaggt tgtagtgagt tgagatcgtg 7440
ccactgcact ctagcttggg tgacagagca acactctgtc tcagaaagaa taaaaagatt 7500
tggccatgaa ttcgtcagct agttttcctt acataatttt tggacaagga gatctgacat 7560
tcataggttt ttctcttaga agtgggagag cttcaaggtc acgtggtccg tccagcccct 7620
gctatctcac cagacactgt ccaccctgta tgttggatca gtactccagt gagaagacag 7680
caggcacttt cacccatgca gcccattcag tcttcataac cacctgtgat ggaggcaagg 7740
caagtatttc agccccctct gatgagtggg aaactgagat gtgccccctc tctgctcccc 7800
accgaggacc tctgcatgca ggcatgaatc ccaggagcct agctgatatt ggagagacgg 7860
ggcgggggga accagctgca gggtcttgga ggaagctgct gtgtacacct gcaaggctgc 7920
aggttacatc tatctgtcaa gcagtgaagg aaggaagttg tttctaaggg attggaaaaa 7980
ttcattaatt agtagaatga gaaactgagg tgaagcagga ggtggcaggg tcccagacag 8040
catgttggac tagtggcctg tgtcactgtg ttttttgcag gcgggtggca tggggtgtat 8100
gctgacttct tattccagga gttggtgcca ggaggccagg ttttcttaac atccttgttt 8160
tacagatgtc aaacttgagg gccagagggg taggagagga agagactttt tgtacctttt 8220
ttgggaaaga acaagaggga agctggcaga tgaatttgaa gtgcattgac cagggagctg 8280
agagagggcg gtctgcagcc agcccacacc tgggaggagg cggcaggctt ttctggggac 8340
agagtggcca agtcgaagca agcttaacca tctcaacatg acaccactct ttcccattgg 8400
aacctgagaa cttgttcagt attctgacac ttagcaaggg acctgggttt tcttggtcag 8460
gtgtgcgttt ctgggtgaca ggcctgcatc aggtgtattt tcgggatgta gtaagttgtg 8520
gaatatgggt ttaggggcat cctctggcaa gcactgcttc tatcccagct ctgggaatgt 8580
gccccatgca gtgtcctaga tggcccatct gtggtctgct tccaagggtc tttcttttag 8640
ttagttagtt ttgagacaga gtctcactcc gtcacccagg ctggagtgca gtgatgcaat 8700
ctcggctcac tgcaacctcc acctcccaaa ttcaagcaat tctcatgcgt tagcctcctg 8760
agtagctggg attacaggcg tgcaccacca cacccagcta atttttgtat ttttagtaga 8820
cgaggaattt caccatgttg gccagtctgg tctcaactcc ccacctcagg tgatactccc 8880
gcctcagcct cccaaagtcc cgggattgta ggtatgagcc aacatgccct ggcacaaggg 8940
tctatctttg accaatggaa ctgcaaatca agcctctttt gttaccagag ttaccttgga 9000
tttaccctta tctacttggt ttggataaat tgagtttgca tcagatggag tcaggcttga 9060
tcaatccctt atttacttcc tcccaccctg ttctctaata tccaaaaacc ttgaggcact 9120
attacatgct agctacattt ccttgagtaa agtacttaac ctctttgagc ctcagtttct 9180
ccattgcata aaaggaataa taaaacttat cccccataag tttatagtga ggaatgaatt 9240
aattcctcac tatagttcta aattaattct acttagggca tccttggtac atagtgggtg 9300
ttcagtattc atttcatttt ctcttttctg attcctttcg taaaagtaga aaaatgaaag 9360
agaaatgttg acttctcttt tgatttgaaa tcattaaaac attttagtaa gccttgggag 9420
ggagctagtg gtgtggcatg tgtatcccgc tggccaagca catgtgaacg aagccaagaa 9480
tccaggggct tttctgccag ccagcactga ctcacttgcg aggggccctg cctggctcgg 9540
gggaggcagg gctgaagtac cacattaggg catgttccgg ggaagtagat tctctgaata 9600
acttggatgg ctccctggag catttaggac agaagccacc tggaaaatag agatggtcac 9660
ccccacgtag ccttgacagt gcccagaaag tcttgtcact tggtaaatgt taacagctat 9720
gatccgttct ttaagaccct ggggagtttt aagttttacc ccaccagacc tgagaagggt 9780
aaagggctgc agattctgtt cttttaactg gggccagtgt gagccatctt tgactcagtg 9840
cttgcaatag accttgattc tgcagtggga cctcccaggc ccccttgccc cccgcaactt 9900
ctggactcat atccgtcaga catcacttgt caccttccag catcagggag aactggatcc 9960
ctcctggctc cacactctta ggctctttgt aagtagctgg tgagggtttt cttctctctg 10020
caagggaggc tggtagaact atggatgtga ttcgtacaat tttagagaca aaaagaaagt 10080
acccaggagg tcatttattt cagctgcttc attgcatagg tcggggagtt gagcatggag 10140
tccagcagct actaactagt tatctctgta cctggcttcc atttactggt ccttagcttg 10200
ttccgtgatt cttcattgcc ccttatttct caccagaggg actggttggc cctagatgga 10260
gtggtctttt taaaattttt tttttaaatt ttttgagaca gagtctcact ctgtcaccta 10320
ggctgtagtg cagtgctgcg atctcggctc actgcaacct ccgcctcctg agttcaagca 10380
attctcctgt ctcagcctcc tgagtagctg ggattacagg tgtgtaccac tatgcccagc 10440
taatttttgt atttttagta gagatgggat ttcaccatat tggccaggtt ggtcttgaac 10500
tcctgacctc aaatgatctg cccaccttag cctcccgaag tgctgggatt gcaggtgtga 10560
gccaccgcac ctggcctggg cagagtgaag tcttatgctg gggagccatc agcatgctca 10620
aacctcctgc aattgtagca cactttgtaa aactgtttcc cacaaaaggg cagaactatt 10680
tgggactttc atgagaccat tcactttgta gcacatacta ctttgaagtt tataccttgg 10740
aaaacctcat gatggtattc ccaggcttgc acgtaatctg cactcaaaac atagctgtag 10800
aattgaacta aagcatccct ctgtccaatt aagacctata acctctcttt ttgagacaga 10860
atctcgctct gtcacccagg ttggagtgca gtggtgcaat ctcagctcac tgcatccttc 10920
gcctcctgga ttcaagcgat tctcttgcct tagcctccga agtaactggg actacaggtg 10980
cgcgccacca cgcctgggta atttttgtat ttttagtaga gacggggttt cgccatggcc 11040
aggctggtct caaactcctg gcctcaagtg atcctcccgc ctcagcctcc caaagtgctg 11100
ggattacagg gtgcaccacc acacccagcc aggacctatg atctaattca ttgttggggt 11160
agcttcacaa ttttcttctg gacgccttag taagtccaca ctttaagcag ccaccacatg 11220
gcatacttta ccttctgttt ttcctttccc ctcccctacc tagaccctcc taacttttgg 11280
ggtttttttc ctttcctcag ggtcagtttg aaaaggagga tcgagctcac tgtggagtat 11340
ccatggagat gtggagcctt gtcaccaacc tctaactgca gaactgggat gtggagctgg 11400
aagtgcctcc tcttctgggc tgtgctggtc acagccacac tctgcaccgc taggccgtcc 11460
ccgaccttgc ctgaacaagg taaggtgctg gctgggggca gcctggactc ctgggccttg 11520
ggaacaggat gggctgggag ggaggtgata tggttgcagg tgatgtggtc aacagggaag 11580
gctccttccc aagtggagca aagaactccc ttcctgtagg agaaactctc aagatacctg 11640
ggttggttct ggtctggtta taaacataac tgacttcatc agaggttggg gtcatgaagg 11700
ctggtgacat ccatttacct gagatgacat gtttgtgggg ggtaatttat gcttttctct 11760
ttctgaggaa agaatatctg atgaggaccc tagtgtcaca ctttaacata ggtgatgtat 11820
aaaatgcagc tggtggtgca atggggagag aatgacctta gaatttgcgt gtagaacttg 11880
ggtcagacta caggggatgt tgtaggaggt gagagcttgc taaagacctc tgacttccag 11940
aaaattgttt caaggccaca tcttcgccag gcatagtggg tcacacatgt aacctcagca 12000
ctctgggagg ctaaggcaag aggatcactt gaggccagga gttcaagatc agcctaggca 12060
atatagcgag accccatctc tacaaaaaaa aaggaaatta actgggtgtg atggtgcacg 12120
ctgctagtcc cagctacttg ctactcagga ggctgagaca ggaagattgc atgatcctaa 12180
gagttgaggc tgcagtgaat tatgattgca ctactgcgct ccagcctggg tgaaaaaaag 12240
gcacatcttc tataagggtc agcagtcatg gcttcacgcc tgcattttcc tatccttaac 12300
tgtgtctcac aggttctgtt tgggggcctg ccaagcgatt tgctttggat aggtactgtt 12360
tgaggggttt tgaagtgatt gagacccagg aagcataaag gggcatggag acctatggcg 12420
tgttggaaat tcagagccat catcggtaac aggaaggact taccccacca ttcttgggat 12480
ctgtgtgagc tgtggaaagg cctcttggga gattataggt acagaatacc ggtggctttc 12540
gcgggacttt gaaaactaat gtatgagcat ttctgctgcc agaggatagt gtggttcgtg 12600
actcagtggc tggtcacaca gagaaggttg acacacagtg ggtgaaaggt tggaggtgcg 12660
cgtgatgggg tggctgtgtg caaaaggctg ccactcagct ggtcagggac tcgtttgaat 12720
gatgagtgat gggtgagaat atgtgtcctc tggatggagt tggggatgaa cagggaaagt 12780
tgtgtgagac tttatagaag gtgcagtggc tagagcaggc atattcatgt tgctgtcagt 12840
aacagaaccg aaggcaaggt ctgagctgga gcacggtggg gacccaaagt gggagagact 12900
gtgtctgccc acagggagtt tatggtcagg agggatgggc aagtacaggg ataagtaaca 12960
caagacagac tgtgtttaaa ccacccagtg aagttacaac cagaggtggt gggaatgcag 13020
aggaagaggg gagcagagag cacctgagat gggcttgagt tcagaagggg aaaaatgaag 13080
ggccctccag gttgaacagc atgagtgttc agagacagca tgtatatggt ttatggagaa 13140
cggtttgcct ggtgagtagg tagctctggg aaacaacact tggaaaaatt ggattgagtt 13200
agcatatgga aggcttaatg ccctgctaag aaaactatac ttagggccgg gcacggtggc 13260
tcacgcctgt aatcccagca ctttgggagg ctgaggcggg tggatcacaa ggtcaggagt 13320
tcgagaccat cctgcctaac acggtgaaac cccatctcta ttaaaaatac aaaaaaatta 13380
gccgggcgta gtggcaggcg cctgtagtcc cagctactcc agctccagtc tccagctgag 13440
gcaggagaat ggcgtgaacc cgggaggcag agcatgcagt gagctgagat cgcgccactg 13500
cactccagcc tgggcaacag agtgagactc cgtctcaaaa aagaaaaaga aaactatact 13560
taggccaggc gtggattatg ctggtaatct caacattttg ggaagccgag gcaggaggat 13620
tgcttgagcc aagaagtttg agaccagcct gggcaacatg atgagaccct gtgtctacaa 13680
aaaatagaaa aattagccag gtgtggtggc acatgcttgt agtcccaact attagggagg 13740
ctgaggtggg aggatcactt gaacctggga ggtagaggtt gcagtgagcc atgatcacac 13800
cgcttcactt cagcctgggt gacagagtga aactctgtct aaaaaaaaaa aaaaaaaaaa 13860
agcaagaaaa gaaaactaga cttaaatggg tagatgctgg gaaacttgaa aagtttttag 13920
caagtagtga cactatcagc tttcagaaag ttaatttggc agctcagtgt ggatggctgg 13980
gaggaaagag tgaggtgcac ctgtgtttgc atcctgctct gccacttgat agctgcatta 14040
tttacttcaa caaactactc aaacaccata cgtcacagtt tgctcatctg taaaacaggg 14100
ataaataata aagggttaag tggggtaatc cagatgaagc acttccatgt aaggtgttaa 14160
tagttgctat tgctgccact gctgctgcca gaaggatgag gtcgcaggtt attttgagtg 14220
tctggctaga ggaagtgcag gtactgacca ggatggggac tgggagatga tagaggaagg 14280
aaaaagtagt aaagacacta cagcaatagc atctgtgggt ttaagtaggt tgggtgtcaa 14340
ctgtgggcaa ctggagactg agatgagagt gtaaagggag tgagtcagag tgggaggttt 14400
gaggggagtt tagatttgaa tccgccaatt gtagacagcg ataaaggagt ggaagagtag 14460
caaggagcta gttgaggttt gagaatgtga atttataatg gagcctaaag tactttcttt 14520
tttttgcagc ccaagaaggg agaagtggat ctcgggcctg gctgcttgtg agccagcccg 14580
acgggatgag tataaggaac tttagggcca gggtgggggt gctagtagag gagggggctt 14640
cacggaagct gctggggcag ggtggaggct ggaacctggg ggctgaagat cttgatgagg 14700
acaaagtacc ggccctgtga acagaagaaa gggagtaaga gaggtggatg gggctcttag 14760
gagccatgta cccaggaaga ctgacattaa atgaccattt tttaaaaatc aacttaattt 14820
tcaaaggcac attggctccc acctataatc ccagtactgt gggaggcaga ggcaggagga 14880
tcacttgagc ccaggagttt aagatcagct gggtttgttt gtttgttggt tggttggttt 14940
taagagacag agtttcactc tgttgcccag gctggaatgc agtggcatga tcttggctta 15000
ctgcaacctc tgcctcccag gttcaagcga ttctcctgcc tcagcctcct aagtagctgg 15060
aattacaggt gctcaccact atgcctggct aatttttata tttttagtag agatgggttt 15120
caccaggttg gccttgaact cctgacctca agtgatctgc ccacctcggc ttcccaaagt 15180
gctgggacta taggtgtgag ccaccacacc tggccaaacc aacttaattt aggtataaca 15240
gtttgggcta ttgtaataag actgctgtga accttcatgt gcaagcctgg gtgggcacac 15300
attttccttg gactgccctg gttttgattt tggctccaca ccttactgac tgttggctct 15360
tggggaagtt cctctttgtg cccttttata aaatatattg ataatgaatg tgtgctcata 15420
aggtcattgt gaatatcaaa taagcatgtc tgcagagctc ataggacatt gcctggtccg 15480
taggccatga gcagtcaatg gccgttgtgg gtccctttcc ctgggcctcc aggggagacg 15540
gcacatggcg aggagcatgt tgtttcatgg gacacagcaa cggaaagccc ctgcacttgg 15600
agaacaagcc ccaggtctct gtttggtgga gtaagccccc gtctcagtgt gagtgtggtg 15660
ctttcacata gcctgtctct catgagcttt gtgacagaac agagaactgc tgtgcccagg 15720
acattctaag gggagatctg gcttcatgct ttgtaagctg taaggaacct tgtaagtgta 15780
aagtatattg catagtcttg ggcctgctga ttattaaata ataatgctga tattttttaa 15840
ttaattaatt aatttatttg agacggagtc tcactctgtc gcgaggctgg agtgcagtgg 15900
cgtgatcttg gctcactgca acctccacct cctgggttca agcgattctt ctgcctcagc 15960
ctcccaagta gctgggatta caggcgcgtg ccaccacgcc cagctagttt ttttgtatat 16020
ttagtagaga cggggtttca ccatgttggc caggatggtc tcggtctcct gacctcatga 16080
tctgcccacc tcggcctccc aaagtgctgg gattacaggt gttagccacc atgcctggcc 16140
aatgctgctg ttgtcctaaa aaaaaaatca tagggcgagc acagtggctc acacctgtaa 16200
tcccagcact ataggaggcc gatgcaggag gattgcacga gcccgggagt tccagaccag 16260
cctgggcaac atagcaagac cccatctcta aaaattttaa aaattagctg ggtaacgtgg 16320
cacacatcgg cagtcctagc tattcaggag gctgagatgg gagaattgct tgagagttgc 16380
ttgagcccag gagttgaggc tacagtgagc tataatcaag ccactgcact ccagcctggg 16440
tgtcagaagg agaccctgtc tttaaaaaaa agaagaaaca cattataatc tatgtattaa 16500
gggctttgtc caaaaggtga gagcaaacca cctaaaaccc tgttcacact gagttttccc 16560
catttaaaag gccttgctgt gattttaagt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 16620
gtgtgtgtgt gtgtctgtgt gtctgtgtgt ctgtcgggag cccctcccca ctgagcgcag 16680
taccaacgcc cctcagtctg caagtgctcc tgagggattg gggagggcct ggagtttctg 16740
gctgtccttg gaaagttgat ttaataaggg ttccaggaaa accagcctcc ctcccctctc 16800
cctctccttc ccctcctttg gtttgggatc ttacagagcc tcagcttgtt tcagatcagg 16860
ctttgagagt ggtgagggag ttgtttggaa agactgaagc cggtttcaga tgataagccc 16920
caacattctg agcttgcaga gggtgcattt gtctgtcttt tgcaataagt caagtcttgg 16980
tgggcaaagc cagtgagtga gtacaacact gcttgcaagg ccactgctgg tagttggggt 17040
gggggtcctg cccccttttc agcagtactg tgggttaaac accccagtgc tcagaaaacc 17100
tgcagctcag aagtgattta atgggctgag ttttacagct cctcccaccc acccagattt 17160
gaaggagtct ggtggcttgt tagagggggg agaggttgca cttaatggaa aaaccacaca 17220
tttccattct ggcctcaagc cccctggatg ccctgtgtgc accacaaagc ggggctttgt 17280
ctctgtgttt tgcagaaacc tgcacctatg ggggagaggc tgtgcgtggt gccagagcca 17340
ttgcctagcc tcagatcata gggcccttgc aggtcctcca tccctgggcg tctccagctg 17400
cctttggccc aaaggggtgt gcgtttcagc ctggctgcag ggagagtctc aaataggtac 17460
tacaggtttg gtagtgggac accctctgtt ccactatcag acctgtagtc tagcatctac 17520
actggactgt ggtcctgtgt cccaaggctg ccttgggaca caggcaagac cctcccctac 17580
tcccacccca tctccagcat gatttcttat gatgaaaaga acttgtttgc ttctcattca 17640
acctggatgg taagaggagt ttcttcatcc cctgccagaa ggcgaatgga attccatgga 17700
gcaaaaggtg atgtcagatg accctcttga gaacaagggt ggaggattta ggcctctaga 17760
aatctgcaag gtgctaagct cataacaggt ttccccagag gatcagctct gtcccacttc 17820
ccctggagaa gtggctccag tgcctggaag gggtgtttgc aagtgttcag agctggacag 17880
ggaggaccca gccctcggcc tgtgagagaa tgtgaggacg ctcacgtggc cctcttgacc 17940
aagctggggc aagcgcagca aagccactcc gaggctgtgt tcttggctcc ggcttctgca 18000
ttgctacacc attagcttca ctgattttcc actctggctc tgccaggccc gctccctgaa 18060
gtcagggagg aggaatttct cagggaagaa caaatggctg tccagagatc ttgctgccag 18120
tgggggaagg gagggatccc aaacaaagac tctgtcaggg tttccatcac ctggttcctg 18180
tgactacctg gagtcgggtc agcaggaact ggagagacag catcagggat tctttgggag 18240
cctgtggccc cagcacggag gggtgtttgc tcctggccag gcagaagcag tgagtgatgg 18300
cttgtgtctg ggcggtgatg aatggccctg ggagaagtga gtcctgggga gtcattatcc 18360
gggagggcga ggtctggggt cagagagccc gaccagcagc tggccctatt ttcacaatgc 18420
ctcgttcctc cggggccact gggggctcca gctcaccctg tagacaccac ctttgcctct 18480
ttcttccttc cctgaggctt ggaaatgaga caactgtttc cctgttgacc ggggaagtcc 18540
agctgctctc attctcctgg gctcctgaac ggggcggccc aggccttcct cctgggcctg 18600
gctctttcac caacttgcag gcaggcaatc ccttctcccc acccaccata ctccccagcc 18660
ccactgcacc ctaaataatt aagctgaaag ctaactgccc tacctggatc tgaagggcct 18720
gggctaaatc ccaaactgtt tcctcctagg agaagcctgc tggagtctgg gccacttctg 18780
accttggggt ttgctctgac ttacagctgg tggcagccaa gtagcagggc caattgccct 18840
aacccctcct ccccggtagt gggcctgttg cctcttagca ttgccagtgt ggcaccaaga 18900
gacattgaac ttctaccctc agagttccct cccttctcct gtttcttggc tcacaacagt 18960
tcttgccttt ccacttgcca aacaggtatc tactgccttc atgtaaagca tttgtgccct 19020
gcaaactagg ggctgtgggg tgagggctcc gtgtagctgg tttcaggcac tgagaaagat 19080
ccaccctggc agagcttgaa actccacgcc ctctcctcgt tcacatgctg tggcgtggct 19140
gagcctcccg ggatgggttg tgtaaaaggt ggggtggggg ctgtgccatt tgtgttccca 19200
ggccctggac atggagacac agggagcctg aagtgggtga gagggtcaag gagttccgca 19260
aagagtagac ttagtggtta cgaggttggg cagagaaaga ggtcagaaac agcaacacgg 19320
aggtttctag gagttaacca acagtgaaca ttgaattcag agcttagccc ttcctcactt 19380
ttctctagga tcaaaaacta gcttctggct aatggtccat tcattgactg attttttttc 19440
actcattcat ttattcattc atctagtcaa gcaagtctct tcctttttcc gtaaatacaa 19500
tgtatacttt atacattgtt ttatcctagt cccttagctg gaaatatctg ttcctgtcct 19560
tttcttcctt ttcacttttt ataattcctg ctcaaatctt agtttaaggt ttagcttggg 19620
tttagattaa agcttaactt aagggccacc tcccttttga agccttcccc tatctccaaa 19680
ttaattaccc cattttttct ctttttcttt tttctgtgtt ttttttttct cctgagacct 19740
agtctcgctc tgttgcccag gctagagtgc agtggagtga tcatggctca ctgcagcctc 19800
gacctcctgg gatcaagcga tcctctggcc tcagcctcct aaagtgttag gattacaggc 19860
atgagccacc atgccctttt gagatgtagt ctcgcttagt catccaggct ggagtgcagt 19920
ggcgcgatct cggctcactg caacctctgc ctcccaggtg ctagcgattc ttctgcctca 19980
ccctcccgag aagctgggat tacaggcacc caccaccatg cccagctaat ttttgtattt 20040
tttgtagaga caggttttcg ccatgttggc cagtctggtc ttgagctcct gacttcaagt 20100
gatccacccg cctcagcctc ccaaagtgct gggattacag gcgtgagcca ccacacctgg 20160
cctcttttta actttcattc taacacttac tttactctgc ctcacattat gtggagtttt 20220
taatagatgt ctgtttactc cactagagca aagttctcta tagtcagcaa gtatatcttt 20280
atcactcttt taaaaacatt agtgtttagg ctgggcgcgg tggctcactc ctgtaatccc 20340
agcactggcc agcctggcga aaccctgtct ctactaaaaa tacaaaaatt ggccaggtgt 20400
ggtggcacgc acctataatc ccatctactc aggtggctga agcaggagaa tcacttgaac 20460
ccgcgaggcg gaagttgcag tgagccgaga tcgcaccact tcacttcagc ctgggcaaaa 20520
gagcgaaact ccgtctcaaa aaaaaaaaaa aaaaaattgg tgttttgtta gataatctgg 20580
gttcatcttt caaaattcag aaaatacaga cctgtaaaga ggaaaaggaa gactcctata 20640
attccatcat tcaaaagcaa tcactgttaa ctgaatttat tgttttagac ttttttcttg 20700
catttatgta aacctgactt ttcagaatta ggatttatac tgtatacgat gttttgtgac 20760
tgatatcagc atttagagcc atacagagaa tgtttttcat tatgcttaag aactacataa 20820
tgttccattg tgtgggtgta caaagttgat ccagttctct acatttgggc atttaggtta 20880
ttttcaatag tttgcattca atagaacata ttcttacaaa taaaatctgt ccatgtatcc 20940
aaggatagtt ccatttgttt taagttttga ttttatcact attacatcac tataccaaat 21000
atcccccaaa agattatacc agtaaatgtc ttttaaaata taataataaa taccagccgg 21060
gtgcagttgc tcacacctat aatcccagca ctttgggagg ccgaggcagg cagatcactt 21120
aaggtcagga gtttgagacc agccttggta acatggcaaa acccttctct actaaaaata 21180
caaaaattag ccggtcatga tggcggccac ctgtagtccc agctactcag gaggctgagg 21240
caggagaata gcttgaaccc aggaggtgga ggttgcagtg agctgagatt gcaccactgc 21300
actccatcct gggcgacaga gcaacgctct gtctcaaaag taataataat aaatatcatc 21360
tccacactct gcatgcttga cattttccca tttttacaat gattccatag gcataggttt 21420
tatgaccata atcagatgag taaactgagg tttgaggggt taagtaacct atcttaagtt 21480
tatatagtgg gtgaggggtg gaactaggat ttaaactcag gtggttctgc tatagtattt 21540
ttttcccatt gtattacact atttttctat atcaaattgg gtttccccac aaaatctagg 21600
tggaccaact tctgaatgta aacattgctg gctcagtccc ctttgtctca caggagtcag 21660
gcatcccctc cctttgtcag gggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 21720
gtgtgtgtgt gtgtgtttgc ttgcagtaat atctcctgtg gcattctgta gagaggttac 21780
acatcagtca caggtctgtg aactgcctta atgaacaagg ttccctagcc tagaataatc 21840
aatggaacaa aatccccatg gacgctgcca tttccactgt tgccaaagac ctacatggag 21900
aaggttccca aggtgtcaga tccgacacct gagttttctt tataggtcac agttagccta 21960
gaatgtgtgg tatgggtatt gcctggacgc ataaactaga ttgcttctaa tatggatgtg 22020
gtccaacaat ctctgatgaa tggaagtaaa catatcaaaa gcttcagagg ctgggacatt 22080
aacatttttt tgaggctact agtgtttttt ataaataatg aagaagggcc aggcgcagtg 22140
gctcacacct gtaatcccag cactttggga ggccgaggtg ggcagataga gtgagctcag 22200
aagacccgct tgggcaacat ggcataaacc ccatctctac aaaaaataca aaaaattacc 22260
tgggcgtggt ggtgggcgcc tgtaatccca gctactcggg aggctaaggt aggaggatca 22320
cctaggcctg gtgtggtggg tcacacctgt aatcctagca cttttggggg ccaaggtggg 22380
ctgattgcct gagctcagga gttcgagacc agcctgggca acacggtgaa accctgtttc 22440
tactaaaata caaaaaacta gccgggtgtg gtggcgggcg cctgtaatcc caagtactcg 22500
ggaggctgag gcgggagaat cgcttgaacc agggagtcag aggttgcaat gagccgagat 22560
tgtgccactg cactgcagcc tggctacata gcaagacttc ctctttaaaa aaaaaaaaaa 22620
aaaaaaaaag gtgggagagg gctgagtcag tttgccttgg aggcatgggg gaggagaagg 22680
atgtgaacag ggaagtgatc taagagcttc cctaggaagg aaggacaccc ttttcctgga 22740
atgctctcct gctctgccac agctttcagt caattatcac tgcctttaga atgcttatca 22800
gcactccagc ccttcagaag tgtccttctc ctcctctggt gtcaaactcc agagtttact 22860
tttggaatta aggtttattt tccttaggtt ttaggaagta gcttttgaac cttagaagag 22920
tcagtttcct ttactaacta ctgaatgaag ttaggcattc aaaacttggg tagtcatgat 22980
ttgaagtgtc acttgcggcc aggcacagtg gctcacctgt aatcccagca ttttgggagg 23040
ttgaggcggg cagatcacct gaagtcagga gttcaagccc agcctggcca acatagtgtc 23100
tctactaaaa atattaaaaa aaaaaaaaaa taaccgggcg tgatggcagg cgcctgtaat 23160
cccagctact ctggaggctg agacaggaga agcacttgaa tccaggaggc ggaggttgca 23220
gtgagccaag attgcaccat tgcactccag cctgggcaac agagtgagac tccgttcccc 23280
aaaaaatgaa atgtcaattt cattgagact gtatgaatgc ctgacatgca cttgaaagtg 23340
atgtttattt tataatttta gcccttcttc actaccccaa actcccagtg catttaaaaa 23400
atttattggc ctagccattc tcatggggta atatatcatg accatcaaaa gatgacacta 23460
aagtgaatcc tccatgtata gctgggcttt ctgccagcct tagattctgg agaagcaccc 23520
caggccaggg agaacgggtg aagaggagaa gcatttattg aaggtgctgg tagccggagc 23580
cctgagacca acacagaatc gttttttctg aaggacaact caaggacagt tgagggctct 23640
tcacttccct cacatcagag ggagctttgt gctcacgatg ggcacggaaa gggatgccag 23700
taagcgatgc ccctctatca tctcacaaga cccaggtgaa acaggacatt ggttagggct 23760
gggacagggt cagtcagcct tctcatttta cagtggagga agctgaggct tgagagggga 23820
ggtgacttgc ctgaggtcac acagtaagtg atcagctgtc atctgagtga tttcttcagg 23880
tactctctct ggctggaccc agccagtgac aactacctgt ggctcaagct gagtttggga 23940
ctaaatggtt ttacaaggac ctcaaagtat actctctctc ttctagtagg acatggggaa 24000
tactgacttt gctgagagta agggctcttt tcccaggatt gttctagatc cccagatcac 24060
tggaaccctg agcatagata ctaggcttta gcttcctggc taccacagag ccacacactc 24120
tcaggtagaa aaatccctaa actggctggg catggtggct catgccagta atcccagcac 24180
ttttggaggc ccaggcaggt ggatcacctg acgtcaggag ttcaagacca gcctggccaa 24240
catggtaaaa ccctgtctct acaaaaaaaa aaaaaaaatt tagccacgcg tggtggcaag 24300
tgcctatact cccagctgct tggggggctg aggtgggggg atcacttgag ccagggaggt 24360
ggaggctgca gtgagctgaa atcatggcac tgttctttag cctgggctac agaatgagac 24420
cctgtctcaa agaaaaaaaa aaaaaaaccc gaaccatgtt tttaatttct taaaactgag 24480
agtactaaat gctcaacgtt catgttgtgt gcataaaagt gagactgaag gatgaatgtg 24540
tggggtatgg atagatggga tgtgaatgaa gcagtctctg ggtccaagct ctcctggaaa 24600
ttcgtggaac agaccagtgg tcccagattt ttagatttca taggccagta aaatttccct 24660
ccagattttt ggaaccaaca aaggatcatc aacttttttg ccaagtaaga acgtttttaa 24720
taaactaatg ctgcctgcta ccattaccac ctgattcttt tttttttttt tttttttttt 24780
tttgagacag tttcattctt gttgcccagg ctggggtgca atggtgcgat ctcagctcac 24840
tgcaacctcc acctcctgag ttcacgcagt tctcctgcct cagcctcctg agtaggtggg 24900
attacaggca ttcgccacca cacctggctc attttgtatt tttagtagac acggggtttc 24960
tccatgttgg tcaggctggt ctcgaactcc tgacctcatg tgatccgccc acctcagctt 25020
cccaaagtgc tgggtttaca ggcgtgagcc accgagccca gcgccatcta attcttttgt 25080
tgtggtaaaa tatatgtaac ataaaattaa ccattttaac tatttttatt tttttaagtt 25140
aaattgatta tgtaatgttt ttgagacagg gtcacacttt gtcacccagg ctggagtgca 25200
gtgttgctat ctcagctcac tgcagcctcg acctcccggg ctcaagagat cctcccacct 25260
cagcctccca agtagctggg accacaggtg cacgctacca tgcctggcta attttgtttt 25320
tctttttttt ttttttttgt agagatgagg tctcactttg ttgctcaggc tgatctctaa 25380
cccctggact caaacaatcc tctcacctca gcctcccgaa gtattggagt taagagatgt 25440
gagccactgt gcccggccaa tttttaaatt tgtaattgat gcataatggt tatgtataat 25500
cgtcgggtac ggtatgatgt tttgatccac gcacacatta tgtaacgacc aaatcatggt 25560
aattgctgta ttgtatccat cactttaaat atttatcatt tctttgtggt gcattttcac 25620
caattttaag tgcacagttt tgtagcataa aatttattca cgctgtgtag ccatcaccac 25680
catccatttc accttccctg acaccttacc tgttcaacgc taactccccc ttctcccctc 25740
ttccagcccc ttggtaacca ctattctaca gcttttcatt ttcaaaggat gttttattgt 25800
ctttagtctc atcgtgtgaa accttaagag aatttcttta cggtggagaa aaagtaactt 25860
tatgaagccc attcctttct ctactctgga gaggctggtg acccagcccc accattgcag 25920
gaatgagacg ggattgcggg gatatggcag gcacttgggg tgctgagagt ccaggtgaac 25980
tgtgagctca agcacccatg tcgggcttgg gggaccagaa gacacatcct gaaacagctg 26040
aagcctctac taattcatca gcaagtttag ggagcggcaa cttttccctg cccagctgct 26100
ggcgtttcct tccccataca atttctgctg agtttggggg aggggaggtt gttcgagagg 26160
ccccagctgg gagaggtggg gggagggcga tacattcttt tccttaagga acctgaccga 26220
actttaaggt cagagctcag tggagagtgg gagctgcagg gttacctctt tgccgttgat 26280
tcatctctcc accctccccc actcttaatg atctttccat tacagaaccc agaccaggaa 26340
gtgcatgaca ggtcgcagct gcagacacat ggctgggagg cctgggctcc gggccagtgg 26400
tgggagagtc tgagctcccc tccagcagtg ggacccctgc acacacacac acacacacac 26460
acacacacac accactttaa caacttggtg gaagatgttc tttcttatgc actgtcacag 26520
gtgatgacga gttggacttt gctttgagtt taggatgtga tttatattat aataaaggca 26580
ggagaagaca ctccccctgc cccggtccaa cctgagtgtt tagatccccc caacttacag 26640
tccacctaag tggtccttac cagatcctgg gagctttcta ttatcgtgca gatgccccaa 26700
cttcttttcc caaaatagga cccacccaat atggccttag aagcttccca gggtatccgg 26760
ggcagttgct agtcacagtc ttaatgtctc cgaaatagta tgttttcctc tctatgtttc 26820
tattaaaatg tcagccccaa aacatgtttc tgggtggagg tctaggtgca acagcacagc 26880
ctttgcaaac acagatagac ttgggttcaa gtcataatag atgagttgag cctctcattt 26940
ttcagtcttc attggggatg gctctttcca tttgcaagtt gttcaggaaa tgttaattga 27000
ccctaaactg tgtcctaggg ggcagttgtc acacaggagt ttctgtcttc accaccagct 27060
gtgtccttgg cttccttccc tgaatctgcc aaggctggat tctggtgcta aatgtgaaat 27120
ggtgacacaa acttctagga actgtgagct tggacggccc tcctccatag ccgcagggca 27180
tctacctttg ctcttcttgg atgagtgaat gaacttccct ctttccagag caatgctttc 27240
ttcctgttta gataggaggg agagaagcaa agtgtattgg gaataggttg agcgaaagag 27300
tgtagtaaga gttttctgta cagctctgtc cttaatgtat cagtaaacaa tagggtgaga 27360
acttttgctg gggagagagg aaggagggaa atttcttttc agacaactct tgggtgcatt 27420
cctttgttaa tcacttaatt acagcccttc tcccagtgag gtagtgaact ccccattgtg 27480
agaggtaggg aggaggtggg ggacactggt gctgattgga gaaaggtggc aaaatcccta 27540
ggggaaaaaa gtacagattt gaaggaggca tcagatgaat ccgtgcatag aagcttgagc 27600
cccaaactca gttctcaggc tgcgttatcc tttacgacac ccagagtccc tctgtctttt 27660
aagatccaca cacaactctc caggccaata gctcttggcg cctgcgattc ccaagtggga 27720
ttctacacgt gtcttgctgc ccagctcggg gggatctgtt tttggggggt ctcggggcgg 27780
gtgcagggtc ctggctgtgg ctttggctag tgcaggcggc tcggcactaa attacagtga 27840
cgaggtggga cgcacaaaag gccgaaatct ttttttaata aaaacaaaac aaaactctgg 27900
gccccaagcc cctgggctgc tgaatggcca tggcttcctg tcaggattag ccgggctgcc 27960
tgggcctgtg tgctcggcct ttctcctcag gaaatacctt tagtaagccc cggtggggtc 28020
cccatggcaa cgcacggggg gacctgctgg cagaggccat tcagtctgcc attgtccccc 28080
ggcccctttg ttgtgagctt tattgccggc cctctggcaa acacagcagt ttgcaccgtt 28140
ttgtcaggct gaatgtggag tttttacatt ttaatgggct cttctggcag tggcccattt 28200
gcatgcaaaa tgtcccctct tactcttttc actttcttca atttaaaaaa aaaaaaaaag 28260
cccttctcca aatcccctgg gtcggggggc tggtggacgc cattggccct gggtgtcagg 28320
ccctgctaat tgatttggtg ctcccggctc tctttccaca catacctgtg ccccccattt 28380
ttgcagctct ccttctattt ggggactccg agagttgaga gaaacacatt tttggggctc 28440
tctccaccca aacccttgta ggatggcagc tgtgacccgg gatttcggtg agatgcttct 28500
gcactctggc cgggtcctgc cagccgaagg taagttttca gttccatttc aaagccaaaa 28560
tacgtaataa aaaaacctct gcagagggcc cccggagccc cgctgcgctg ttctgtgctc 28620
cttttaagtt gctttcaaag ccaccccgag ttcctccccc acccacaatt gccccctcat 28680
ttatctctgg ggagtttata ccaagactgt aaacattcct ggaccaccag tttcccccat 28740
gttgctgagg agtttagcct ttctctccta attttcttaa ctcagaaatc aaaaagatgg 28800
aatagggatg atagaaattg ctaccctgag acatcatgct catggaggat gcctggattt 28860
tgttgggggc cagttatcca agccctaagc cctttggagt gtagaacgta gagtaggtaa 28920
tacaaatacc tactgtcagc ccagcacccc agcaacatga gtaagtgcaa gacacaggca 28980
tgaacatttt cagctctagg gaaaggcaca ttcatgttgg ggagaggtgg agaatgcagt 29040
ttggccagtc tcagaagagt gagttttaag gcctaggaaa gtgatggaga tgattgcttg 29100
ttggagagag agaaggagaa aggcatttag gggaagaaaa ggaaaatgaa aggagcagtg 29160
aggatattgg ctccactggg gaggtggaac tggggtagtg gccgaaccag gggtgggaga 29220
ggacgtggtt gagaggctcc agaccagctg gggctgtcat ggagtgttgg gggtctggag 29280
cagtcaggac ttgaaagccg ggacccttgt gagccctgtg cagtcctgag gatgtggccc 29340
aagggggagg gcggaccagc tcttttgcct cgtgttctta atcttctcag tgggtcatca 29400
ggggtcatca gctgtaagct gtaatcaacg gtgaggggct cgagaagaga aggtgtcagg 29460
tgactgctgg ggattgagct gaggacagga gaggcagggt gctgtctcct gtggcccagg 29520
cagagcggca cagacctgga gtgggccacc cctcatcacc ccatgtgctg cgacagtgct 29580
ggctggactg aaccctggaa gagtacctgg acacagtgga ggggccagga cccagcagat 29640
gcagcctcta gagcttgtcc ctgttttgtg actttgggag ccatttttcc atgtttaaat 29700
gggaaggaac acaagtcacc tggtcacaag gaagcaggcc ctatgaaata ttaagtgcaa 29760
tgccaaaaca gggcattgtt actggtcttg agtctgccac aatcacaatg aacacctccc 29820
ccattttctc acctgccaca tttggacagc cgagcctgct ggactcgcag gggcaggaga 29880
gtgcatttta taattaaaag cactcaactg taaggtaatg attgatatga gctatgggct 29940
tgaggaaatg agggaaggag gggaggataa ggccaaagca accaacttca gaatctcacg 30000
ggaggaggta ggatgcaggg ggtgccatta gacagaatca aagggctgaa ccagaagggc 30060
ttcctcacct ggggaagtca agacactgtg aagattgagg ctgccttgca cagcggtaaa 30120
gctggactct ggatgtatga tgtatgtgga ttctggagaa ccaggctacc tgtgtttgaa 30180
tcccagctct gccacttaac aacctagctg ggccatcttg gactaatccc aaatctttct 30240
gtgccccagt ttccccctct gaagataata attccttttt tttttttttt ttgagacgga 30300
gtctgggtct gtcacccagg ctggagtgca gtggtgtgat ttcggttcac tgcaacctct 30360
gcctcctagg ttcaagtgat tctcctgcct cagcctcctc agtagctggg attacaggcg 30420
tgcatcacca cgcctggcta attttttgta tttttagtag aaatagggtt tcaccatgtt 30480
ggccaggctg gtctcaaact cctgatctca ggtgatccac ccacttcggc ctcccaaagt 30540
gctaggatta caggcattag ccactgcact gggcccgaag ataataattc taactcttaa 30600
atacttcaca agattctaag ttaacacatg ctgagaacta tgctggtatg tagtaagcct 30660
ccgcatccat aggatagaaa tcatagtagg atcaacctca taagtttcct atgaggatga 30720
aatgggaggg tctgtgttaa aagctttgtg cagcctatgg gatatagtga gcgtgctgga 30780
aatattggcc agtagtagta ttgctgttta ctcagatgtt tatggatccc tagataatat 30840
atgggaaggc acatggtaaa ttacaaagtg ctatgcaaat gtgttgttat tcttcactgg 30900
gttcctgtta agttgtgggg tttggggatg gataacttcc agaccagagt ggctgctgtg 30960
ggaccgggct ggtgaagcgg tatttcaaaa tacattttca ggtgtgtttg tccatgtggc 31020
atgaatgccc tgcattcata gtctctgcag agaggtgtgt tccctgggat atctttggtg 31080
gctctgttct atccctcaac ttacaaattg aaatcattat ttgttactgt tttctcccat 31140
gaaccttctg ttcctggcca gctgtacagc ctggcctcat ctcccactgc ccctcagacc 31200
agggtacagc catgcctgta agcacttcat tctcttctgt tccccccaga catttcactt 31260
ctcatctaaa tcctctcttt tcccttcccc gtcattttgt ccaacctctg ctctcactgc 31320
tgatactttt ctttatgttt catgacgtca gagcctgtgc tagacctgcc tgtacttggt 31380
cctgacattc tccatttgtc tcatgttgca gtataaaatc ttaatccata ttaaggtgct 31440
gtgcaaatct gagcacccct gttagggcaa gacatatgcc ttctgggcct ttgtttcacc 31500
catttctcct tgcacagtga caagggctcc cagagtcacc taatggtagc tatgttgatg 31560
aaagttccct gactcctcct tggatttttg agaactgggg tctcatcttg tcataagaat 31620
agcaaggttt gtatgggttt gggtctctga tggttcccat gactggtgga agacacagat 31680
ttagaatcaa gaattgggag gccgaggtgg gtggatcact taagttcagg agttcaagac 31740
cagcctggcc aacatggcaa aactccatct ctactaaaaa tacaaaatta gccgggcgtg 31800
gtggcgcttg tctatagtcc cagctactcg ggactgaggc acgagaatca cttgaacctg 31860
ggaggcggaa gttgcagtga gccaagatcc cagaactgcc ttctaaatga ctgtgggaga 31920
tttttgtcca gtcctgctag aagcaaaatg ctgtacctgt tggcttgttg gaagtacaag 31980
cctgcagtat ttggggggaa agtaggaagg gaagagggat tcagtagggc ctcattatca 32040
ttaatcgtgt tcctgaactt gaaagcacca tgggaaaatc ccctcccacc cctgcctctg 32100
tcctttctag ctgcttcctt gaggattatc aaaaagtgtg ggtctccggt gggctcctaa 32160
ttccttctta ggggatagag acaccttaga gaagcagggt aggtttgatg tatgaatcct 32220
tgtcactcgc actaaaagga gcactggttg cagcctgcac aaattcccaa ggtccacccg 32280
ccagctgctt tgacccagga acctgcgtgg taatgagatc agcagcctga gttctcgaac 32340
gatgttcaag gcaaacccta accctgacct tcccactcct gttgatgaga acggtgactc 32400
cattctattg gcatcaaagc ataaggcccc ttttttttca caatgcactt tttttgttgt 32460
tgttgagaca gtgtctctgt tgcccaggct ggagtgcagt ggcaagatta tagctcctgc 32520
agccttgagt tcctgggctc aagggatcct ccctcctctg cctcccaagt gcctggggac 32580
tacaggcatg caccactatg cctggctaat ttttttattt ttcgcagaga cagggtctca 32640
ctatgttgcc agggctggtt ttgaactcct ggcctcaagc agtcctccca ccttggcctc 32700
ccaaagggct gggattacag gcatgagcca ctgcacccag tccgcaatgc actgttaaca 32760
catggcacct agagcctgta atagtgaaca gccagtcttt ttcagcctca ggctaggtca 32820
ccagggaatc cagataccag atgccctcca gcctccattc cccacctcat ctctcaggaa 32880
acagatgcac aaagcaagtg ttttggtgct gcttccctca cagcatcccc atgtgcattt 32940
tgaggacaac ctttgtatct gattccaatt aatcaggttc tccaggagtt ggaatgttgg 33000
tttcaagtga ctgaacaata aagtggcttt cttcatcttt cttggccagt ccaataaaag 33060
tgtcaggtag cttttctctt gctaatggac acctaacgac accctggcct gttggtcttg 33120
accagagaaa ggccagctca gggcagctgg agctgaagag gcaaggacct ttctaatgag 33180
gacataagtg agggacactg gaaagaccaa aagagaatgg aaagtactga catggtagtt 33240
gcagggtgct agtgagcagt catgccccca aatcagccac cttacataga actccccaag 33300
ttcagggcca ctggatgggg ttgtgacgca gtcaagcagg gcccagaaag catacaagca 33360
gttggtttca tctcctgtaa gaaagtggca tcatccctgc tttgtaaacg gagaacctga 33420
cacacaccaa gagcactcct agccgtggaa aaaagccgct agaacccgag gttagtctga 33480
tttttggttc ctctgaaaat tagcttttgc tggatgctag attcagttct ggacttactg 33540
agtagtctct gggtttttga cattgttagg cactgtggga aaattataac aggtacgtct 33600
gcgctgagtt gcttgctaat tcctaggaga gacttggaca ttttggacaa ttaagaagca 33660
atacaggcca ggcacggtgg ctcacgtctg taatcccagc actttgggag gctgaggcgg 33720
gtggctcatc tgaggtcagg agttcgagac cagcctgacc agcatggtga aaccccatct 33780
ctactaaaaa tacaaaatta gccaggcgtg gtggcacatg cctgtaataa tcccagctac 33840
tcgggaggct gaggcaggag aattgcttga actggggagg caaaggttgc agtgatccga 33900
gatcacgcca ttgcactcca gcctgggcaa caagagtgaa attctgtctc aaaaaaacaa 33960
acaaacaaaa agaagcaata cagctctttg agaaagatgc agtcataagt ggtgcagagt 34020
tgcagtctgc ccattcctgc tcctcactca tcgctgttcc gaacaagtca gccaggaagc 34080
cgcactgcac caaggctttt aaagatacca gaaaacacct gtgaagctgg aggtgaccat 34140
tcaccaaatt cgaatccctc taatgatccg cagcgtaaaa tccctggaga aggtgtgtgc 34200
tgacttgatt cagaggagga aaggaaaaga atgtctaagt gaagggacca gtttgaatgc 34260
ctgccaagac tttgagaatc actataagaa aatctccttg tggtgaaggt tcagagacat 34320
gggatcgttt ccagatgaga atccacaagc tacccactga cttgcacagt ccttctgaga 34380
ttgttaagca gttgacttcc atcagtgttg agccaggaat tgaggtggaa gtcaccattg 34440
cagatgctca aagtcaacta ttttaataaa ctgattagcg gttgttataa aaaaaaaaaa 34500
aaaaagcagc agcaatatgg gttgagcgca gcggctcaca cctgtaatcc caacactttg 34560
ggaggtcaag gtgggtgggt tgcttgagtc caggagttca agaccagcct gggcaacatt 34620
tgaaatttta acttattttt taaaaaagaa agaaacatta tacccaatat ctgtcaattg 34680
atgactgcaa tgtggtatgt ctacacaatt gaatattatt aggtcattaa aaggaacaaa 34740
gtgctgattc tatgctataa catggaggaa gtttgaacac atgctaagtg aaagaagcca 34800
gtcacaaaag atcacatatt gtatgattcc attgatatga aatatctaga atagccaaat 34860
ccatagacag aaagcagatt agtggttgct tagactgggg ataggggatg gaggagtgac 34920
tactatgggt caggcatttt ttgaggggcg agggatggta aaaatgttct aaagtgagat 34980
tgtggtgaat gattgcacaa ctctgaatat acaaaaacca ttaaatggat gaatattaca 35040
gcatgtgaat tacctgtctg ctgtttaaat aaaatagaaa caatacaaaa tggaatgtaa 35100
ttgagtgtga atttgtgtga ttcaggcggt aactgtttta cagaaaatta gagatgagac 35160
attgatataa acaaggcttc ctagtttctt gttttgtttt aagacagggt ctggctgggt 35220
gcggtggctc acacctgtaa tcccagcact tgctaactga agatgcaagg accgaggcgg 35280
gcagatcact taaggtctgg agttcaagga cagcctggct aacatggtga aaccccatct 35340
ctactaaaat gcaaaaataa gccagccatt gtggcatatg cctgtagtcc cagctgctcc 35400
agaggctgaa gtgggaaaat ggcttgaacc tgggaggcag aagttgcagc aagccaagat 35460
tgtgccactg cactccagac tgggcaacaa agcaactctg tcttaaaaaa aaaaaagggt 35520
ctttgtcatc ccgtccagtg gcatgatcat agctcaccgt agcctccaac tcctgggctc 35580
aagcaatcct gtctcagccc actgagtagc tgggactaca ggcatgtgcc accaagtctg 35640
gctagttttt aaattttttt gtagagacga ggtctcacta tgttgcctag gctggtcttg 35700
aactcctggg ctcaaatgag cctcctgcct cagcctcccc aagtgctggg attgcaggca 35760
taagccactg cacccagccc ctggacgttt tggatggtgg actttgagta gtttggggta 35820
ggaggactct ggagtggcgc tgacagtcct caggaaggag taagctttgc catgccaggg 35880
aggatgcagc cgtgctgaaa gcatcccaac tggggagggg ggggggcgcg gtggggaggg 35940
acagcccctg gtagagagaa tggggctggg tggagagagt ggaagccaat tgcagggagt 36000
cttgaaggtg aggcagggat gtggatttta ctctgtacac agggtagatt ttgatcagga 36060
aaataatgtc aagcacatga cagcttggaa gcaggagtct gagctgcagc cccagggagg 36120
ccatttaaaa gattatcccg gctgggcgcc atggctcatg ccagcacttt gggaggccga 36180
ggcaggcaga tcacgaggtc aggagcttta gaccagcctg accaacattc cccttctcta 36240
ctaaaaatac aaaaattagc tgggcatggt ggcgcatgcc tgtaatccca gcaactcagg 36300
aggctgaggc aggagaatca cttgaacccg ggaggcagag gttgcagtga gccgagatcg 36360
cagcacttca ctccagcctg ggcgaaagag caaaactcca tctcaaaaaa aaaaaaaaaa 36420
aaaatttatc ccgagatggt tccggtaaag ggataggaca gagcatacct gagccacgtt 36480
tggaagggaa ccggggtcta aacttgcatc aggaggaaag cgagctggtt cttgaggctt 36540
ttacagatca cgtatagtgg agttttgttt gcacgttctg gttgggacgg gcaggaagtt 36600
acggatccaa gctggtatca gctagagcgg gtctcaccag ggccagtgtt cctttgctgc 36660
attctcttgg ggggaaataa atgcctgggg gttctctttg ctacattttt gtctttggga 36720
gctgcttttt tctctgggat cggctgcaat aggccttgtg atgccagagg gtaagaattc 36780
aagtttactc ttgaccaatg ggttgcacag atcacaagct gcaaaatatt taatcaccga 36840
ggtcatttga gggaaatgag atttgatcaa tagaagtgtc tgctctgttc cttaagagtt 36900
gagtctaaac tgcttttctc cttaccttcg tttggcaaaa ccacagacca ttaaaaatgg 36960
aaagaataac tttttctaag gcccacaaaa gcttattttt aatcagttgt gtggtctact 37020
cacctttgtg gtgttcccct tgaccggact cacaaaaata aacgtgtgca agcctagtgg 37080
tttctgagcc cttttaaagc agtacccctg tttctgacaa ctcttattta agataaagcc 37140
catgggtcaa tgcaggactg ggtctgcaac cttggccccc ccaagagaaa ccactgtcag 37200
tccctgtcag ttgctgatca tgatgcgcgg gacacccatt ttcattttta aggtttctag 37260
cggaagcctg ttgagcactt gaggaagacc gtgtttcaaa taagggggag tgaaagagaa 37320
aagggagagt agaaaggaag gcagtgaaga gccagagtga ctgcacgtgt ggtatttatt 37380
gagcaagcat ttcttgagca actcctgggc gccaggcatc gtagtaggtg ctggggattt 37440
aaaggtaccg atgacacatc accgcactca ggttcagaaa gaggactgcc cttcagtgtg 37500
acaggtgcca ggagggggag ggcacctaac ccagactggg agtcagcacc gccctggagg 37560
agaagtcacc agctaggctg agacagaaga gtgagtagtg agagctggac agaaaaaaat 37620
caggggccct gtggccactg gggcagccgt gagccacagc aggggctgag ggagaacatg 37680
ctgtttcaga gccttatgca tcggggagcg gcagtcgctc cactgagtct cttagggtga 37740
acaaatggtg agaaaagtcc tctccaaggc tgtgggcggg atgtgggtgg taggtgagag 37800
gtggaagatg ccaggagtac atttgaacat cctaaaagga aatagaaagt tcatttcccc 37860
tcgtgagtgc agaggggtgt gctcaggaga tgggtaacag cccaggatgg tgaactcagg 37920
tgtgtccggg ccacgggcct tcttgaacgc gtgcgggaag aggcactggt caggggaggg 37980
acaggtgctc ttggtggtat cagatcttgt gaggtgcaga caccccggtg ggtccagtgc 38040
tcccacccag ggacagagaa ggatggggca cggggaggga gagtggatgg tggggggcct 38100
gagggtgtgc ccagtcagag ggctgaggag aaaggacctt tgtgtgcgac agctcctgct 38160
gccagagcaa gtgtgggttt tatggcagct gtggcctccc gtcctaatat agtcaacagc 38220
tccaaatccc ctgccctgac acctgttagc gagaggttcc ctgagctgac ctctccttgg 38280
gctgcccccc cagcatgtgc atctgacgcg tcgagggcca gacccccacc ctctccgaat 38340
cacacgcatc ctggtcagcc cccagttgac aaattgcctt ctctcgactt gggcaggggc 38400
tgctggggtt ttgaggggcg gggtttgttc agctgttgct agggaagggt gaggctgagc 38460
tatcccaaag gaaatggggt gttcctctgg caagtggcaa tcttggcaaa gaactgagca 38520
tctggggagg gggcaactcc ggacacaaag aagtcctggg gagggccgac ctttcccctt 38580
aggatggggg aaatgaaatg cgcttaatgc tgctacagct gcttcctaac tttgcctctt 38640
tcttcctttg acttttggag gagtggggtg gaaaagagat gggggttccc aggcagccag 38700
ctgttttccc cactgaccca tgctccaatt cccactgccc tggctcagta gcctccagta 38760
agtgatgccc aggatggtgc ggctccgtgt ggccagcgta attccctttg tctctcccct 38820
cctcccctct ccctgtcttc ctctctcgcc ccttggcttc ccttcccggc cccgtggtgg 38880
ctgcagccca gccctgggga gcccctgtgg aagtggagtc cttcctggtc caccccggtg 38940
acctgctgca gcttcgctgt cggctgcggg acgatgtgca gagcatcaac tggctgcggg 39000
acggggtgca gctggcggaa agcaaccgca cccgcatcac aggggaggag gtggaggtgc 39060
aggactccgt gcccgcagac tccggcctct atgcttgcgt aaccagcagc ccctcgggca 39120
gtgacaccac ctacttctcc gtcaatgttt caggttggta gccaagccct gcccttgccc 39180
ctccctagac ccaccccctc cagccctctc tgccagtttc agaggaaggt gaacctcctc 39240
cccctccgtg atctgccccc actctgcttc agaaactgct gcccactaac attgctccct 39300
gcctgccgcg tggcttggct ctcagagagg tgactaggtg gggtgggccc cagggccgga 39360
gatctggggc ttccaggaca cacctcggag gtgattgcca gggctcttgg gatgttaaga 39420
ccctgtgatt tttttccacc acagcttgcc cagatctcca ggaggctaag tggtgctcgg 39480
ccagcttcca ctccatcact cccttgccat ttggacttgg tactcggctt agtgattaga 39540
ggccctgaac aggtggtggt atccctgctc tgctggagag gaacccaggt gcaccgcaag 39600
ggagctgtgc gagggcagcc agggagccct ggagctctgt gaacttggga acttgccact 39660
cttagaatgt gactttcaca aaactaggag ttgaggaagt ggagctgaaa ttttctttat 39720
gccatttatg cacctcaggg tgtggacttg gcagcagatc cccaaaggtg ataggaagga 39780
ctggagaaag atctggcatg aaccctgatg ggtgaccaca tgtgtatcaa gcgtgttctt 39840
acaagaaata aatacttatt ggggagaggt gttggcagct gctggggtgg tgggtgccct 39900
atctgctctg attaaggagg gcagccccca aaccttagta gacacatgct agaaaaattc 39960
tgactgtggg gtgtttagcc catcctttgg aaatagcatc tagccacagt gtgtctagac 40020
ctgcctgggt ttccctatag tcagccgtcc aaagaagaat acaggttgcc tggctccagc 40080
acacccaggt ggcaccacaa gttgagaaag cgcctttgaa tgtaggacgg aattaagtta 40140
aataggaaca gctgaccctg atggaaccac ccagtgtgaa ggcttccagg cagtgggggc 40200
agtgcttcgg ggaaggaagc aaacacgcac aggaactgtt cttaaacagt ttccatccca 40260
ccaagagatc atcactaagg gagcagtggg actgggatcc ccatggggag ggtgtccgtg 40320
ttcatctgga actgcactag ccttggtgaa atctaggggt ccctaggagg aacctcagtg 40380
ccccttcttc ttcccataga tgctctcccc tcctcggagg atgatgatga tgatgatgac 40440
tcctcttcag aggagaaaga aacagataac accaaaccaa accgtatgcg tgagacactg 40500
tttcctatct tactgccctt tgggtctggg cattgggttt aagaggggag gggaaggctg 40560
aaaggggagg aagaggaggg cacatggggt cacggtgcct gttctgctaa gtgccaggca 40620
ctgctcacag gtgttgggca gatgggcaag acacctccag gtcctggcct gggccctgct 40680
cctgagcctg accagctgct cctctccacc ctgcctgtct ctcttggctt tccccgggca 40740
gccgtagctc catattggac atccccagaa aagatggaaa agaaattgca tgcagtgccg 40800
gctgccaaga cagtgaagtt caaatgccct tccagtggga ccccaaaccc cacactgcgc 40860
tggttgaaaa atggcaaaga attcaaacct gaccacagaa ttggaggcta caaggtacgt 40920
gtgtgtgcat gcgaaagtta gagtaatggg aacaggggag gccgagttag gaagtcctga 40980
ttacatgctt ttcatttttt taagtaatac tttccaccta tacaggttat tcattaaaat 41040
ttttaaatac aaaaaaatgc aaataaagtt taaacatttc ttcagtcttc tttctgtaat 41100
atggttttta catagttgat cacatcatgt atgtaatttc cttgccttgt catttgttaa 41160
catgagtctt ttcctgatat atttcaagca tgaatatttg aaacataatt tttcatgact 41220
gtataagatt ccattatttt aaaatcccat aatttggctg ggcatggtgg ctcacgccta 41280
aaatcctatc actttgggag gccgaggtgg gcggattgcc tgagctcagg agttcgagac 41340
cagcctgggc aacatggcga aacctcctct gtactaaaaa tacaaaaaat tagccatgtg 41400
tggtggcagg ctcctgtaat cccagctact ggggaggctg aagcaggaga ttgcttgaac 41460
ccaggagaca gaggttgcag tgagctgaga tcacgtcatt tcactctagc ctgggtgaca 41520
gagtgagact ctgtctccaa aaaacaacag aaaaagtcct ataatttaat gaactatttt 41580
gtgatattag gtattttctg gtttttcacc ataataaata atgttgcagt gaatctctgt 41640
cagcattttt ttaagcgtgc ttccttagga cagattgtta caagtgaaat tactaactta 41700
aagggtgtaa gcattttttt ttttttttta gacggagtct cactctgtca cccaggctgg 41760
agtgcagtgg tgccatcttg gctcactgca agctccacct cccaggttca tgccattctc 41820
ctgcctcagc ctcccgagta cctgggatgt gcagccacca ttcccagcta atttttgtat 41880
ttttagtaga gacggggttt ccccatgttg gccaggctgg tcttgaactc atgacctcaa 41940
gtgatctgtc cgcctgggcc tcccaaagag ctgggattac aggcttgagc caccgcaccc 42000
agccagaaat attttaaatt aattcaccat gcactcacta catgcaagac accatgcttt 42060
aaatgctgca agatagcgtt cctgcccata aaaattttgc agtctgatag gaggcaaatg 42120
tccatgagca gctaccgtaa aaagtagact gtgatcagtg ctttggtagg cagagaggaa 42180
agggtgagca cagttctgac cagagactgg actggaggag atggtttttg aaatgagctg 42240
tcaaggacag tgggggctgg attcttagtg taataggaga ggtgcacagt tgggaacatt 42300
cttggtgtat ttgggagtgt ttgcagaagg cacatctgtc cggatcacga atgatcttga 42360
acgtcacagt ggagacttct ggagtcttta caccccatct gccagcttgc agagtgtgaa 42420
cgggctggta ggggggcaat ccacgccttg tcctagccaa ccctgcagcc tggggccctg 42480
tgccaccagg ctctgatatg gagggcaggt gccacggggt gccgacattg tcatggggcc 42540
tgcattttcc tctggaccct caatgtatcc ctttggcatt tcccctcagg tccgttatgc 42600
cacctggagc atcataatgg actctgtggt gccctctgac aagggcaact acacctgcat 42660
tgtggagaat gagtacggca gcatcaacca cacataccag ctggatgtcg tgggtaagag 42720
ggcagaggca gcaggaggaa tgagtttagt gggaagagcc aggcttggag aacacagccg 42780
gggtgtccag gtttcttagg ggcagagtca ggatagcgat tggcacttct tggctttgtc 42840
accttgagca ggtcacttct cccttttgag cctcactttt cttatctgta aaatagagtt 42900
aagatcagac agtaacacgg tcaaagctgg ttgtcactgt gaaattgaag gtgctgttca 42960
gagtctgtcc tgaaggaggc gttgttggag aggtgttaaa tgtagcgtaa taggagctgt 43020
cgcttaatgc tagcaagatg ccaggctcct taaatacctg ccctgtaatg ctcatggcac 43080
acctgcaagg tgggcagtat tagtctagcc ctgcacagga gcacaggcgc ataggctcag 43140
agaggtcaga caccttgcta atgcagaact gcacacctgt gccaacttca gggcatcaca 43200
ggagactctg ggaagaacat tgagcctctt ggagctatta ccgcaacctt ttccttctag 43260
gagttctgaa actcactccc tagagatcat tgggtacaga atctctcagc cagtgttctt 43320
cttgattatg atgatatggt ctaagaagga gattgtggcc aggagcagtg gcttatgagc 43380
tccaggtggc atgatgggat tactcacgcc tgtgatccca tcactttagg aggccaaggc 43440
tggaggattg cttgaggcca ggagtgtgag accagcctgg gcaacacagt gagaccctgt 43500
ctctataaaa aaatttaaaa attagcctag tgcagtgtca tgtacttgta gtaccagctg 43560
agttaactga ggctactgag gtgggaagat cacttgagcc caggaattcg aagctgcagt 43620
gagctatgat gacacccttg tgctccagca tgggtgacag agtgagaccc tgcctttaaa 43680
aaaaaaaaag gtaaaaagga gattctgatc caagaggttg gggtaagatc tgagattccg 43740
cgtttctaac aagctcctag gggatgctgg tagcactgct cgtggaccac actttgaata 43800
gcaggagtca aagtgactct ggttttttaa ggaggagcag gttgtgctga ggtctggggg 43860
tgcaactgaa ttagaaggtt ctccattaaa gcatgagcga cttactgtga ctgtaaatat 43920
gatgactgcc ttggggagga ggatcctgat ggcttagggc ctgaagagag ggtgtccctt 43980
tccccagctc tgttttgaga ggcttgggct cagcagaagt gctgggaggt ttacaaccca 44040
tcactgggaa agccaagtgg ggcgcaggtg agcccacccc tctttagcca tggcaaggtc 44100
cccatgacaa gtgcctcctc tcccatcttc cacagagcgg tcccctcacc ggcccatcct 44160
gcaagcaggg ttgcccgcca acaaaacagt ggccctgggt agcaacgtgg agttcatgtg 44220
taaggtgtac agtgacccgc agccgcacat ccagtggcta aagcacatcg aggtgaatgg 44280
gagcaagatt ggcccagaca acctgcctta tgtccagatc ttgaaggtaa tcatggcacc 44340
agtcttcgtg ggccagtcta ctgggaagga gaccactgtc tcgggggctc aagttcctgt 44400
gggcaggctc agttgccccc gaatgggatc attcctcacg cttcaggcac acacactcca 44460
tctcagtagg gatctagcca catcccccag gactagtaac agaggtcaca aagtggaggt 44520
gagctgggaa cagagggctg cagggatggg tggtgctggt ctgtaataag ctttgagagc 44580
aacgtcactg gggctttggg gtcagctaca caaggaaggc atttggaccc ctgccttttc 44640
attgcccgaa accagagcct ttccaccaag cgtttcccag tcttagccct gtgtcctgag 44700
ttacgtacga tctttctggc aaatggggtg catgataaga gcatctctta cgaagagttg 44760
gaaaaacaaa tgccatatat aaattctaag ccatatgagg acgaggagta atggcatttt 44820
cttccttttt cctctcactc ccagacattc attgtccctg aatgctccat taatccaggg 44880
aaggtaattg cctaaatctc cagtggatct cgcaacagga aggaaccaga agctgggaaa 44940
gttgtttacc tctttgtccc agagttagac ctcatcctcc cctagcttag ctgtctcaga 45000
gatatactgg ccctcccttc tcttctcttt gctgctggtg ctaaaactgc tctgtaggtc 45060
attggccact gtctccactc acaacccctg ctccagtcct ggagggagtg ggttaaacac 45120
aaatagaaca ttccatttga agcagtgatt cttttttttt tttttttttt ttaatcaaat 45180
gctttggact tttgaagtcc acttgttctg tacttgtaaa agggaaagaa ggccgggcgc 45240
agtggctcac gcctgtaatc ccagcacttt agatcacttg aggtcaggag tttgagacca 45300
gcccggccaa catggtgaaa ccccatctct actaaaaata caaaaattag ctgtgcatag 45360
tggttggcac ctgtagtccc agctactcag gaggctgagg caagctaact gcttgaaccc 45420
agaaggcaga ggttgcagtg agctgagatc acgccactgc actccagcct gggtgacaga 45480
gtgagtgaga ctctgcgtta aaaaaaaaaa aaaaaaaaaa aactaaaagg gaaaggtaat 45540
aaatctcact taacatctcc cttcgctccc tgggcctgcc tgaaagttac acgggagcaa 45600
cgtgcgtggc cacatctcag ctttgcccaa ctgactggtg tgtcgttggt ttgttccagc 45660
attcggggat taatagctcg gatgcggagg tgctgaccct gttcaatgtg acagaggccc 45720
agagcgggga gtatgtgtgt aaggtttcca attatattgg tgaagctaac cagtctgcgt 45780
ggctcactgt caccagacct gtggcaaaag gtaatgggga gatggatggg accctgtgct 45840
ggggatttga tgtaggcccc aagctgctgg ggcaggcggg gaagccagta ctggactgtc 45900
cttgccaccc tactgtattt ctagtgccca gagccatgga aaaatacccg gcctgggagg 45960
ctggtttggt ttggtattgt gttggtgtct gtgggttccc tctctgcctt ctgtgtgttc 46020
cttggctttg tgtggatcca tgtgaggact cacggggaca cggttttgct gtgttacaaa 46080
tggtacttca gactgaagtt gtgagtgagt ggtgattaag agaaggggcc ataggccagg 46140
cacagtggct cacgcctgtc atcccagcac tttgggaggc tgaggtggga ggatcgcttg 46200
aagccaggag tttgagacca gcctgggcaa catagcaaga ccccatctct acaaattaaa 46260
taaattagcc aagtatggtg gcgtgtgcct gtagtcccag ctagtctgaa ggctgaggca 46320
ggaggattgc ctgagcttag gtcgaggctg cagtgagcta tgtttatgcc actgcacccc 46380
agcctgggtt gacagaatgg taccccatct cttaaaaaag agagagaagg ggttaggcat 46440
tcccttgcat actcgcatct gctggctgtg tatgcacatg tgcgtgtgtg tatgcgtgtg 46500
catgtgtgtg tctgcagccc ccgccatccc tcctgtgttc accttctggc tatctttacc 46560
tgaaaccaaa cagcccctgc ccgccggccc catttctcca tgccgctcac cgcccgcatg 46620
ctcggatggg ccagtggctg ccagcatctg gtgaagggtc gtaaccagcc atcgtcttct 46680
caggtctgcc ggagttcttc cctcagggtc tcaccctctt cctctaacag gttttgctgc 46740
ctggtggttt tcgtttgttc cttgttgcaa agaagatgtc agggagcatt tcttcctcta 46800
gtcccccttc tttctgtctc cttcccttgc tctgcgtctc ttagaggtct catgtcctgt 46860
gcttgtccat tttgcttccg ttgtctcttc tagactgctg gagttaatac caccgacaaa 46920
gagatggagg tgcttcactt aagaaatgtc tcctttgagg acgcagggga gtatacgtgc 46980
ttggcgggta actctatcgg actctcccat cactctgcat ggttgaccgt tctggaaggt 47040
acacactgta acttctcctc tcgatgtcct gccctcgcca cgggcacggg gggagcatgc 47100
atttccaggc ttggggagac acagaggcag gagagctgga agaatgggct cctgcctgcc 47160
tggtgccaca tcctgcccca gctttgaggg ctgaatcctc tcagctcaga gaagagcttc 47220
cctagttttg caggcgcacg gaggcctccc acccgtacac ctgcctctgc tctccccctg 47280
gccattgcaa tgcatgcccg ggatctgggt ttaccctgca gcccgactcc tccagggcag 47340
gctccttccg tccttgggtc cagcagcctc ccccctccgc tgggtactga gcatctgaaa 47400
agtctcagat agggccctac acctcttctc ccttctcaag tgctcagccc aggggtgggg 47460
cttgctgctt gcaaagagca gcccaccctc ctgtactgcc atcctattgc ctttgaagaa 47520
ggaggtcagc ctggacaggt gaactgagtt gccttcagaa aggcctgtct caggcagccg 47580
cagcaggctt cacgatgtcc atgtatcctg tttgcctgct gccgtctctc ctctcccaag 47640
aggggaggtc tgcgtgttga gccagggagg aaggagcctg cagcctgctc agggtggtgg 47700
ctggtgactg cggggccagg gcttgctgct gtctctcgga atgtcctgca tgtgggtctg 47760
gctgttcctg ctggcactgc cctcttctct ctcccctcct ttcccactct gccctgcttg 47820
cccgtcaggg tctccggatg cccctgctgg aggcagagaa gcgttctgtt tttatcatcg 47880
tccctgtctt ggtcctgtcc gtgctcccca tgtgctccca atcagttgtc ttcgttcctc 47940
aacatcaggg aaagaaaaaa cagcaacact tctccctgtc atcagctctg ctgtctcctt 48000
gtcaggcctt gggacgttct ctgggctcag tctagggtcg tgcctcatgc ctcatgcctc 48060
tctgggaagg ttcccagggg cgccgcctcc atggttggct ggtgggtttt aaaggggaag 48120
gttgggagga ggcctgtgga aggaggaggg ccgtccacac ccgtggggca aagcgtgttc 48180
catgaaacca gtgctgtgcg tgctgggatg aaagcctccc agcctctcgt gctgaaggga 48240
aaggtggacc gaactggctt agctgctgtg gcaatggggt ggggggtgag tcctaatcag 48300
aaggtgggag aagagaataa caaaatggaa ctccgccccc tgccgccaca tttccttaag 48360
ttttaggagt tggggcctat gagtagaatt tgaaagaact accaaaaaag cttatttttg 48420
gaaattaagt cagctttgcc tgtggtttgg ctaggaataa atatttacct gtgtgcccct 48480
acagagatga cacagaccca aagtgggaca ttgagcaagg cacaggctgg ttcccctcct 48540
gtcctctgtc ctcattctgt gagtgccacc atcaccaggt actgtggcct gcagaaataa 48600
acgaggcacc aaccctgccc tcagggaccc cgtgtcttct tagggacaga ggactcagaa 48660
acatctgtgt ccccgcatgt taagtgcatg cacacagtgc tgaggctttg cagagaaggg 48720
ccatggctcc ctgaggagac caagaaaggc acatagaagt gacttctcag ctggcccttg 48780
caggatccct gggtgcctgt acctctccag tccagctgag caaggaggct caggaattaa 48840
tgaagatggg gcttgtgtag cacgatggtt ctaggccatc ccttttccat ggctcaagtc 48900
cattgaaggc agcctccaaa atcagggggt tgcctgatcc tcctagtgcc acaatcccag 48960
tcctagctag aacttgccat ggttcttctc cctaaaagtt cccaggggac aggagacagg 49020
tgttgctttt ctaatggagc gggacctcgc atggacgggg ccctccaagc ctgctaacac 49080
cctgttcgca ctgactcagc cctggaagag aggccggcag tgatgacctc gcccctgtac 49140
ctggagatca tcatctattg cacaggggcc ttcctcatct cctgcatggt ggggtcggtc 49200
atcgtctaca agatgaagag tggtaccaag aagagtgact tccacagcca gatggctgtg 49260
cacaagctgg ccaagagcat ccctctgcgc agacaggtaa cagaaagtag atgggggatt 49320
tgcacactca gcaccacctc tctctctggg cctctaatgc cctgccctct ccattgtccc 49380
taatttatag ctttgggcct tattttctgg cttctgggca aggcacagtg gaatatcatg 49440
aactaagtgc tctagagtct gtttcaagct agtgtagccc gtgaatttcc tgcaccctcc 49500
atatcacact gcaagtcctc cggactcctg ggacatggat tgggaggaag tcctatttgg 49560
acagaatgtg cagccaatag catgaatttg aactgtcccc aagggctgct tagaagtgca 49620
gagatgcagg gtagagaaga gaactgtttg tattagtcca ttttcacact gctgagaaag 49680
acatacccaa gaccgggcaa tttacaaaag aaagaggttt aatggactca cagttccacg 49740
tggctgggga ggcctcacaa ttgcagaagg caaaaggcac gtctcacatg gcggcagacg 49800
agaagagagc ttgtacaggg aaactcccct ttataaaatc atcagatctc gtgagattta 49860
ttcactatca caagaacagc acagggaaga cctgccccca tgagtcaatg acctcctacc 49920
aggtccctcc cataacacgt gggaattcaa gatgagattt gggtggggac acagccaaac 49980
catctcagcc ataccatacc cttgtcccct gtgtgcccac ccttccccac gggaggaaat 50040
ggtacagatg gcacaggtgt gtgcaagaat gaccgttccc tcagaagcct gtgctcattc 50100
tggaaggtgc tttgggagtt aggaatccat aagctaaggc aaagtatttg caaagagtca 50160
ggagaacaga gttgttactg caatgatcag ttataaaatg tcaagctgga agaggtgcat 50220
ttggtctgct tattttaaag gtgagtgaag tccagaaagg ccagcttgtg gcagaaatag 50280
gtcagtccta gaagttgggc ctcctggcct accatggtct ttggaccact ctgtgttgag 50340
gaaagaacat cagatacaca gacatgtgcc tctgccattg ttgggaagcc ctgactaaga 50400
atgggaagga gtcaccccgt cccccctcct tgctctaggg tgaccccact cttccttgca 50460
ggtgtctgct gactccagtg catccatgaa ctctggggtt cttctggttc ggccatcacg 50520
gctctcctcc agtgggactc ccatgctagc aggggtctct gagtatgagc ttcccgaaga 50580
ccctcgctgg gagctgcctc gggacaggta ataatacttt gactcccaac tttttgaagg 50640
cattccttgc ttgctattct agtggtggaa ggtgtgtata ctaacacctt ctgggcggtg 50700
aaggttcatg aaatgcctgc agaaacattc attccacttt ctgctcgcag ttgggtgaaa 50760
tacagagagg tggagatggg gtgcctctca aggtttgaac ttcaccagcc ccaacttatg 50820
ccactctctg tttcccccga aagactggtc ttaggcaaac ccctgggaga gggctgcttt 50880
gggcaggtgg tgttggcaga ggctatcggg ctggacaagg acaaacccaa ccgtgtgacc 50940
aaagtggctg tgaagatgtt gaagtgtaag tgatgcttct gtccttgcaa agaaaatctt 51000
gtcccattcc aagcaaacag caggcctcgg gcccagcaga acagcttctc tggtgccttt 51060
gctgcccaca cctgctccgc tgcctgcttg gggttacctg ggagtggagg gggtgttctg 51120
caccttgaga ttgttctatg acgtcactct gttccttggc gtcaacctgg gctgtggtca 51180
ggtgtttatc ctggatccat cgcttgcagg ctttcctcac cacatccctg cccactcact 51240
accacctatt gcaacaacgg ctcccatgag agggaagaga aaacaagttt ggatgaagtg 51300
gggaggagag aatcaagtcc cagggaaaag cagcccctcg acacataccc cactccctta 51360
gcctttatcc tgccctcctc ccttcccaag taaatgagtc tcaacgtgtt ctttaaagcg 51420
gacgcaacag agaaagactt gtcagacctg atctcagaaa tggagatgat gaagatgatc 51480
gggaagcata agaatatcat caacctgctg ggggcctgca cgcaggatgg tgggtgccgg 51540
ccagactggc tttccctgcc cagcggggag aagatctgag ctggggtatc agtcccaagg 51600
cctctctcag ccacagctag ggaagggggt taagagaggc tgctttggca gaggtttaaa 51660
atgtgttatc tcgggatctg ggctccgctc attggtgttc attcaggaat acagatacct 51720
agattcacac acgtggtgtg ttaacagagg cagctgagta attatggtct aagagcgctc 51780
aggctgggtg cagtggctca tgcctgtaat cccagcaatt tgggaggccg aggcaggaag 51840
atcacttgag atcaggagtt cgagaccagt ctggtcaaaa tggtgaaacc ccatctctac 51900
taaaaaatac aaaagttagc caggcatggt cacgcatgcc tataatccca gctactcagg 51960
aggctgacgc ataagacttg cttgaacccg ggaggtggag gttgcagtga gccaagatca 52020
cgccattgta ctccagcttg ggagatactc ccgctgtctc aaaaataaaa taaataaata 52080
ggccaggcac agtggctcac gcctgtaatc ccagcacctt gggagggtga ggcgggtgga 52140
tcacttgagg tcaggagttg gagaccagcc tggccaacag gtgaaacccc atctctacta 52200
aaaatacaaa aagtagccgg gcgtggtggc gcatgcctgt aattccagct actcgggagg 52260
ctgtggcagg agaatcgttt gaacacggga ggcggaggtt gcggttagcc gagatcgcgc 52320
cattgcactc cagcttgggc aacgagcaaa actccatctc aaaaaaaaaa aaaaaaaaaa 52380
aaaaaattag ccaggcattg ttcatgcctg taatcccagc tgcttgggag gctgaggcag 52440
gagaatcact tgaatccaga aggcagaggt tgcagtgagc cgaaattgcg ccactgcact 52500
ccagcctggg caacagagtg agactccatc tcaaaataaa cagacaaact ggggctctta 52560
ccccaatgtt gctcgggaat tttctggact atgctgggag taattatttc tctgattttt 52620
tttgggtagt agaatggatt tcccaggtcc cctaagagga ggcaggagat gggaggttgg 52680
ccggggtgtg ctgctggggg tggggtttct ttgaggtgaa gccaaacctg ctcacctgct 52740
gctggcccca tggcctcttc tcctgtgcct gcaggtccct tgtatgtcat cgtggagtat 52800
gcctccaagg gcaacctgcg ggagtacctg caggcccgga ggcccccagg gctggaatac 52860
tgctacaacc ccagccacaa cccagaggag cagctctcct ccaaggacct ggtgtcctgc 52920
gcctaccagg tggcccgagg catggagtat ctggcctcca agaaggtgtg gaacctgaag 52980
gctcccctgg gtaatgccag ggtgggaaca gagcccccct agtcttccag cctgtgactt 53040
atcatcttgt ggtggcgttg tggatgcact gagcactggc cctgtgtgcc ctgtgtgttg 53100
tcttaggctc tctgggaact gcagagtcag gagcaccagt gtagccaggt ggccttgggg 53160
tcagactgat gcagggtccg atctgtgcac tgccactttc tgcgtagcct caggcagcta 53220
cttagcatct taaaattctt caaatacaaa ataataataa tatcagctgg gtgcagtggc 53280
caaggcggga ggattgcttg agctcaggag tgtgagacca ggttgggcaa tatattgaaa 53340
ccccgtcttt aaaaaaaaaa aaaaaattaa aaaattagct gggtgtggta gtgcgtgccg 53400
atagtcccag ctactcggga ggctgaggtg ggaggctagc ttgagcccaa gagtttgagg 53460
ctgcactgag ccatgatcac accactgcac cccagccggg gcgacagagc aaggccctgt 53520
ctcaaaagaa aataaagtat aacaatacct gttgtagaat tgttatgaag ataaaatgaa 53580
actgtctgtg agtgttgagt gcagtgtttg gtgtgtaagg gctggcctgg tttgagccca 53640
gccccatgtg gacttgctgt gctgggaggc aggacctagg agcatgcatc gctgcagacg 53700
cagcagaggc ataaggggcc agtctttggg gaaggaaggg aggagcgctt gctgtgatga 53760
gaagcctgga gctggcagag aatgttagaa gagggaaagc aaaggttcgg ggggcagagc 53820
agtgtggcag aagttctatg agacaagtcg gctagttgca tgggtggcgg ccgcccagag 53880
ccttccagct ccctcacctc cccgcctccc gctctccctt cctccttcct cagtgcatac 53940
accgagacct ggcagccagg aatgtcctgg tgacagagga caatgtgatg aagatagcag 54000
actttggcct cgcacgggac attcaccaca tcgactacta taaaaagaca accaacgtga 54060
gtgccgacaa ggccgccctg tgctggtggt ttcatctgag aagcaaggag tggggtgggc 54120
tgagaaccca ccccccagtc ccttcccacc tgtgccctca tggccctgcc tggggccact 54180
ccaacctccc ctgtgctgct ttcagggccg actgcctgtg aagtggatgg cacccgaggc 54240
attatttgac cggatctaca cccaccagag tgatgtgtga gtttgtaata gcaattgcca 54300
gggaggtgtg ggatagagag cttctagcac tgtagagtcc tgctttctcc ctggactgag 54360
gagtcctctt tctgccccag agagaaaaac aaaacattgt ctgtggccat tccctctgct 54420
ccagatgttg aaaggctgat ctgttctcca tgctgtctcc tggcactgcc ctgggtagag 54480
gatttgtgct gggggagggg aggcggagaa gctctaacac cctgtggctc tccgcccatt 54540
tgcaggtggt ctttcggggt gctcctgtgg gagatcttca ctctgggcgg ctccccatac 54600
cccggtgtgc ctgtggagga acttttcaag ctgctgaagg agggtcaccg catggacaag 54660
cccagtaact gcaccaacga gctgtaagcc cgaggagatg tcggaggccc tgagccaggc 54720
cttggggcaa gagtgggctt gaggggcagg gggctagact agagagtatc catctccagg 54780
agacgtccct gaccttacag tcctgccgca ggtacatgat gatgcgggac tgctggcatg 54840
cagtgccctc acagagaccc accttcaagc agctggtgga agacctggac cgcatcgtgg 54900
ccttgacctc caaccaggta aggctgcccg tgccagagcc agagctcagg ccgtccccac 54960
tgcgtgcacg cacctccctg agcagggagg aggggcccgg cccatcgctg cttcctctcg 55020
cccatcacag gagtacctgg acctgtccat gcccctggac cagtactccc ccagctttcc 55080
cgacacccgg agctctacgt gctcctcagg ggaggattcc gtcttctctc atgagccgct 55140
gcccgaggag ccctgcctgc cccgacaccc agcccagctt gccaatggcg gactcaaacg 55200
ccgctgactg ccacccacac gccctcccca gactccaccg tcagctgtaa ccctcaccca 55260
cagcccctgc tgggcccacc acctgtccgt ccctgtcccc tttcctgctg gcaggagccg 55320
gctgcctacc aggggccttc ctgtgtggcc tgccttcacc ccactcagct cacctctccc 55380
tccacctcct ctccacctgc tggtgagagg tgcaaagagg cagatctttg ctgccagcca 55440
cttcatcccc tcccagatgt tggaccaaca cccctccctg ccaccaggca ctgcctggag 55500
ggcagggagt gggagccaat gaacaggcat gcaagtgaga gcttcctgag ctttctcctg 55560
tcggtttggt ctgttttgcc ttcacccata agcccctcgc actctggtgg caggtgcctt 55620
gtcctcaggg ctacagcagt agggaggtca gtgcttcgtg cctcgattga aggtgacctc 55680
tgccccagat aggtggtgcc agtggcttat taattccgat actagtttgc tttgctgacc 55740
aaatgcctgg taccagagga tggtgaggcg aaggccaggt tgggggcagt gttgtggccc 55800
tggggcccag ccccaaactg ggggctctgt atatagctat gaagaaaaca caaagtgtat 55860
aaatctgagt atatatttac atgtcttttt aaaagggtcg ttaccagaga tttacccatc 55920
gggtaagatg ctcctggtgg ctgggaggca tcagttgcta tatattaaaa acaaaaaaga 55980
aaaaaaagga aaatgttttt aaaaaggtca tatatttttt gctacttttg ctgttttatt 56040
tttttaaatt atgttctaaa cctattttca gtttaggtcc ctcaataaaa attgctgctg 56100
cttcatttat ctatgggctg tatgaaaagg gtgggaatgt ccactggaaa gaagggacac 56160
ccacgggccc tggggctagg tctgtcccga gggcaccgca tgctcccggc gcaggttcct 56220
tgtaacctct tcttcctagg tcctgcaccc agacctcacg acgcacctcc tgcctctccg 56280
ctgcttttgg aaagtcagaa aaagaagatg tctgcttcga gggcaggaac cccatccatg 56340
cagtagaggc gctgggcaga gagtcaaggc ccagcagcca tcgaccatgg atggtttcct 56400
ccaaggaaac cggtggggtt gggctgggga gggggcacct acctaggaat agccacgggg 56460
tagagctaca gtgattaaga ggaaagcaag ggcgcggttg ctcacgcctg taatcccagc 56520
actttgggac accgaggtgg gcagatcact tcaggtcagg agtttgagac cagcctggcc 56580
aacttagtga aaccccatct ctactaaaaa tgcaaaaatt atccaggcat ggtggcacac 56640
gcctgtaatc ccagctccac aggaggctga ggcagaatcc cttgaagctg ggaggcggag 56700
gttgcagtga gccgagattg cgccattgca ctccagcctg ggcaacagag aaaacaaaaa 56760
ggaaaacaaa tgatgaaggt ctgcagaaac tgaaacccag acatgtgtct gccccctcta 56820
tgtgggcatg gttttgccag tgcttctaag tgcaggagaa catgtcacct gaggctagtt 56880
ttgcattcag gtccctggct tcgtttcttg ttggtatgcc tccccagatc gtccttcctg 56940
tatccatgtg accagactgt atttgttggg actgtcgcag atcttggctt cttacagttc 57000
ttcctgtcca aactccatcc tgtccctcag gaacgggggg aaaattctcc gaatgttttt 57060
ggttttttgg ctgcttggaa tttacttctg ccacctgctg gtcatcactg tcctcactaa 57120
gtggattctg gctcccccgt acctcatggc tcaaactacc actcctcagt cgctatatta 57180
aagcttatat tttgctggat tactgctaaa tacaaaagaa agttcaatat gttttcattt 57240
ctgtagggaa aatgggattg ctgctttaaa tttctgagct agggattttt tggcagctgc 57300
agtgttggcg actattgtaa aattctcttt gtttctctct gtaaatagca cctgctaaca 57360
ttacaatttg tatttatgtt taaagaaggc atcatttggt gaacagaact aggaaatgaa 57420
tttttagctc ttaaaagcat ttgctttgag accgcacagg agtgtctttc cttgtaaaac 57480
agtgatgata atttctgcct tggccctacc ttgaagcaat gttgtgtgaa gggatgaaga 57540
atctaaaagt cttcataagt ccttgggaga ggtgctagaa aaatataagg cactatcata 57600
attacagtga tgtccttgct gttactactc aaatcaccca caaatttccc caaagactgc 57660
gctagctgtc aaataaaaga cagtgaaatt gacctga 57697
<210> 116
<211> 4304
<212> DNA
<213> Homo sapiens
<400> 116
gtcgcgggca gctggcgccg cgcggtcctg ctctgccggt cgcacggacg caccggcggg 60
ccgccggccg gagggacggg gcgggagctg ggcccgcgga cagcgagccg gagcgggagc 120
cgcgcgtagc gagccgggct ccggcgctcg ccagtctccc gagcggcgcc cgcctcccgc 180
cggtgcccgc gccgggccgt ggggggcagc atgcccgcgc gcgctgcctg aggacgccgc 240
ggcccccgcc cccgccatgg gcgcccctgc ctgcgccctc gcgctctgcg tggccgtggc 300
catcgtggcc ggcgcctcct cggagtcctt ggggacggag cagcgcgtcg tggggcgagc 360
ggcagaagtc ccgggcccag agcccggcca gcaggagcag ttggtcttcg gcagcgggga 420
tgctgtggag ctgagctgtc ccccgcccgg gggtggtccc atggggccca ctgtctgggt 480
caaggatggc acagggctgg tgccctcgga gcgtgtcctg gtggggcccc agcggctgca 540
ggtgctgaat gcctcccacg aggactccgg ggcctacagc tgccggcagc ggctcacgca 600
gcgcgtactg tgccacttca gtgtgcgggt gacagacgct ccatcctcgg gagatgacga 660
agacggggag gacgaggctg aggacacagg tgtggacaca ggggcccctt actggacacg 720
gcccgagcgg atggacaaga agctgctggc cgtgccggcc gccaacaccg tccgcttccg 780
ctgcccagcc gctggcaacc ccactccctc catctcctgg ctgaagaacg gcagggagtt 840
ccgcggcgag caccgcattg gaggcatcaa gctgcggcat cagcagtgga gcctggtcat 900
ggaaagcgtg gtgccctcgg accgcggcaa ctacacctgc gtcgtggaga acaagtttgg 960
cagcatccgg cagacgtaca cgctggacgt gctggagcgc tccccgcacc ggcccatcct 1020
gcaggcgggg ctgccggcca accagacggc ggtgctgggc agcgacgtgg agttccactg 1080
caaggtgtac agtgacgcac agccccacat ccagtggctc aagcacgtgg aggtgaatgg 1140
cagcaaggtg ggcccggacg gcacacccta cgttaccgtg ctcaagacgg cgggcgctaa 1200
caccaccgac aaggagctag aggttctctc cttgcacaac gtcacctttg aggacgccgg 1260
ggagtacacc tgcctggcgg gcaattctat tgggttttct catcactctg cgtggctggt 1320
ggtgctgcca gccgaggagg agctggtgga ggctgacgag gcgggcagtg tgtatgcagg 1380
catcctcagc tacggggtgg gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct 1440
ctgccgcctg cgcagccccc ccaagaaagg cctgggctcc cccaccgtgc acaagatctc 1500
ccgcttcccg ctcaagcgac aggtgtccct ggagtccaac gcgtccatga gctccaacac 1560
accactggtg cgcatcgcaa ggctgtcctc aggggagggc cccacgctgg ccaatgtctc 1620
cgagctcgag ctgcctgccg accccaaatg ggagctgtct cgggcccggc tgaccctggg 1680
caagcccctt ggggagggct gcttcggcca ggtggtcatg gcggaggcca tcggcattga 1740
caaggaccgg gccgccaagc ctgtcaccgt agccgtgaag atgctgaaag acgatgccac 1800
tgacaaggac ctgtcggacc tggtgtctga gatggagatg atgaagatga tcgggaaaca 1860
caaaaacatc atcaacctgc tgggcgcctg cacgcagggc gggcccctgt acgtgctggt 1920
ggagtacgcg gccaagggta acctgcggga gtttctgcgg gcgcggcggc ccccgggcct 1980
ggactactcc ttcgacacct gcaagccgcc cgaggagcag ctcaccttca aggacctggt 2040
gtcctgtgcc taccaggtgg cccggggcat ggagtacttg gcctcccaga agtgcatcca 2100
cagggacctg gctgcccgca atgtgctggt gaccgaggac aacgtgatga agatcgcaga 2160
cttcgggctg gcccgggacg tgcacaacct cgactactac aagaagacaa ccaacggccg 2220
gctgcccgtg aagtggatgg cgcctgaggc cttgtttgac cgagtctaca ctcaccagag 2280
tgacgtctgg tcctttgggg tcctgctctg ggagatcttc acgctggggg gctccccgta 2340
ccccggcatc cctgtggagg agctcttcaa gctgctgaag gagggccacc gcatggacaa 2400
gcccgccaac tgcacacacg acctgtacat gatcatgcgg gagtgctggc atgccgcgcc 2460
ctcccagagg cccaccttca agcagctggt ggaggacctg gaccgtgtcc ttaccgtgac 2520
gtccaccgac gagtacctgg acctgtcggc gcctttcgag cagtactccc cgggtggcca 2580
ggacaccccc agctccagct cctcagggga cgactccgtg tttgcccacg acctgctgcc 2640
cccggcccca cccagcagtg ggggctcgcg gacgtgaagg gccactggtc cccaacaatg 2700
tgaggggtcc ctagcagccc accctgctgc tggtgcacag ccactccccg gcatgagact 2760
cagtgcagat ggagagacag ctacacagag ctttggtctg tgtgtgtgtg tgtgcgtgtg 2820
tgtgtgtgtg tgtgcacatc cgcgtgtgcc tgtgtgcgtg cgcatcttgc ctccaggtgc 2880
agaggtaccc tgggtgtccc cgctgctgtg caacggtctc ctgactggtg ctgcagcacc 2940
gaggggcctt tgttctgggg ggacccagtg cagaatgtaa gtgggcccac ccggtgggac 3000
ccccgtgggg cagggagctg ggcccgacat ggctccggcc tctgcctttg caccacggga 3060
catcacaggg tgggcctcgg cccctcccac acccaaagct gagcctgcag ggaagcccca 3120
catgtccagc accttgtgcc tggggtgtta gtggcaccgc ctccccacct ccaggctttc 3180
ccacttccca ccctgcccct cagagactga aattacgggt acctgaagat gggagccttt 3240
accttttatg caaaaggttt attccggaaa ctagtgtaca tttctataaa tagatgctgt 3300
gtatatggta tatatacata tatatatata acatatatgg aagaggaaaa ggctggtaca 3360
acggaggcct gcgaccctgg gggcacagga ggcaggcatg gccctgggcg gggcgtgggg 3420
gggcgtggag ggaggcccca gggggtctca cccatgcaag cagaggacca gggccttttc 3480
tggcaccgca gttttgtttt aaaactggac ctgtatattt gtaaagctat ttatgggccc 3540
ctggcactct tgttcccaca ccccaacact tccagcattt agctggccac atggcggaga 3600
gttttaattt ttaacttatt gacaaccgag aaggtttatc ccgccgatag agggacggcc 3660
aagaatgtac gtccagcctg ccccggagct ggaggatccc ctccaagcct aaaaggttgt 3720
taatagttgg aggtgattcc agtgaagata ttttatttcc tttgtccttt ttcaggagaa 3780
ttagatttct ataggatttt tctttaggag atttattttt tggacttcaa agcaagctgg 3840
tattttcata caaattcttc taattgctgt gtgtcccagg cagggagacg gtttccaggg 3900
aggggccggc cctgtgtgca ggttccgatg ttattagatg ttacaagttt atatatatct 3960
atatatataa tttattgagt ttttacaaga tgtatttgtt gtagacttaa cacttcttac 4020
gcaatgcttc tagagtttta tagcctggac tgctaccttt caaagcttgg agggaagccg 4080
tgaattcagt tggttcgttc tgtactgtta ctgggccctg agtctgggca gctgtccctt 4140
gcttgcctgc agggccatgg ctcagggtgg tctcttcttg gggcccagtg catggtggcc 4200
agaggtgtca cccaaaccgg caggtgcgat tttgttaacc cagcgacgaa ctttccgaaa 4260
aataaagaca cctggttgct aacctggaaa aaaaaaaaaa aaaa 4304
<210> 117
<211> 4310
<212> DNA
<213> Homo sapiens
<400> 117
gtcgcgggca gctggcgccg cgcggtcctg ctctgccggt cgcacggacg caccggcggg 60
ccgccggccg gagggacggg gcgggagctg ggcccgcgga cagcgagccg gagcgggagc 120
cgcgcgtagc gagccgggct ccggcgctcg ccagtctccc gagcggcgcc cgcctcccgc 180
cggtgcccgc gccgggccgt ggggggcagc atgcccgcgc gcgctgcctg aggacgccgc 240
ggcccccgcc cccgccatgg gcgcccctgc ctgcgccctc gcgctctgcg tggccgtggc 300
catcgtggcc ggcgcctcct cggagtcctt ggggacggag cagcgcgtcg tggggcgagc 360
ggcagaagtc ccgggcccag agcccggcca gcaggagcag ttggtcttcg gcagcgggga 420
tgctgtggag ctgagctgtc ccccgcccgg gggtggtccc atggggccca ctgtctgggt 480
caaggatggc acagggctgg tgccctcgga gcgtgtcctg gtggggcccc agcggctgca 540
ggtgctgaat gcctcccacg aggactccgg ggcctacagc tgccggcagc ggctcacgca 600
gcgcgtactg tgccacttca gtgtgcgggt gacagacgct ccatcctcgg gagatgacga 660
agacggggag gacgaggctg aggacacagg tgtggacaca ggggcccctt actggacacg 720
gcccgagcgg atggacaaga agctgctggc cgtgccggcc gccaacaccg tccgcttccg 780
ctgcccagcc gctggcaacc ccactccctc catctcctgg ctgaagaacg gcagggagtt 840
ccgcggcgag caccgcattg gaggcatcaa gctgcggcat cagcagtgga gcctggtcat 900
ggaaagcgtg gtgccctcgg accgcggcaa ctacacctgc gtcgtggaga acaagtttgg 960
cagcatccgg cagacgtaca cgctggacgt gctggagcgc tccccgcacc ggcccatcct 1020
gcaggcgggg ctgccggcca accagacggc ggtgctgggc agcgacgtgg agttccactg 1080
caaggtgtac agtgacgcac agccccacat ccagtggctc aagcacgtgg aggtgaatgg 1140
cagcaaggtg ggcccggacg gcacacccta cgttaccgtg ctcaagtcct ggatcagtga 1200
gagtgtggag gccgacgtgc gcctccgcct ggccaatgtg tcggagcggg acgggggcga 1260
gtacctctgt cgagccacca atttcatagg cgtggccgag aaggcctttt ggctgagcgt 1320
tcacgggccc cgagcagccg aggaggagct ggtggaggct gacgaggcgg gcagtgtgta 1380
tgcaggcatc ctcagctacg gggtgggctt cttcctgttc atcctggtgg tggcggctgt 1440
gacgctctgc cgcctgcgca gcccccccaa gaaaggcctg ggctccccca ccgtgcacaa 1500
gatctcccgc ttcccgctca agcgacaggt gtccctggag tccaacgcgt ccatgagctc 1560
caacacacca ctggtgcgca tcgcaaggct gtcctcaggg gagggcccca cgctggccaa 1620
tgtctccgag ctcgagctgc ctgccgaccc caaatgggag ctgtctcggg cccggctgac 1680
cctgggcaag ccccttgggg agggctgctt cggccaggtg gtcatggcgg aggccatcgg 1740
cattgacaag gaccgggccg ccaagcctgt caccgtagcc gtgaagatgc tgaaagacga 1800
tgccactgac aaggacctgt cggacctggt gtctgagatg gagatgatga agatgatcgg 1860
gaaacacaaa aacatcatca acctgctggg cgcctgcacg cagggcgggc ccctgtacgt 1920
gctggtggag tacgcggcca agggtaacct gcgggagttt ctgcgggcgc ggcggccccc 1980
gggcctggac tactccttcg acacctgcaa gccgcccgag gagcagctca ccttcaagga 2040
cctggtgtcc tgtgcctacc aggtggcccg gggcatggag tacttggcct cccagaagtg 2100
catccacagg gacctggctg cccgcaatgt gctggtgacc gaggacaacg tgatgaagat 2160
cgcagacttc gggctggccc gggacgtgca caacctcgac tactacaaga agacaaccaa 2220
cggccggctg cccgtgaagt ggatggcgcc tgaggccttg tttgaccgag tctacactca 2280
ccagagtgac gtctggtcct ttggggtcct gctctgggag atcttcacgc tggggggctc 2340
cccgtacccc ggcatccctg tggaggagct cttcaagctg ctgaaggagg gccaccgcat 2400
ggacaagccc gccaactgca cacacgacct gtacatgatc atgcgggagt gctggcatgc 2460
cgcgccctcc cagaggccca ccttcaagca gctggtggag gacctggacc gtgtccttac 2520
cgtgacgtcc accgacgagt acctggacct gtcggcgcct ttcgagcagt actccccggg 2580
tggccaggac acccccagct ccagctcctc aggggacgac tccgtgtttg cccacgacct 2640
gctgcccccg gccccaccca gcagtggggg ctcgcggacg tgaagggcca ctggtcccca 2700
acaatgtgag gggtccctag cagcccaccc tgctgctggt gcacagccac tccccggcat 2760
gagactcagt gcagatggag agacagctac acagagcttt ggtctgtgtg tgtgtgtgtg 2820
cgtgtgtgtg tgtgtgtgtg cacatccgcg tgtgcctgtg tgcgtgcgca tcttgcctcc 2880
aggtgcagag gtaccctggg tgtccccgct gctgtgcaac ggtctcctga ctggtgctgc 2940
agcaccgagg ggcctttgtt ctggggggac ccagtgcaga atgtaagtgg gcccacccgg 3000
tgggaccccc gtggggcagg gagctgggcc cgacatggct ccggcctctg cctttgcacc 3060
acgggacatc acagggtggg cctcggcccc tcccacaccc aaagctgagc ctgcagggaa 3120
gccccacatg tccagcacct tgtgcctggg gtgttagtgg caccgcctcc ccacctccag 3180
gctttcccac ttcccaccct gcccctcaga gactgaaatt acgggtacct gaagatggga 3240
gcctttacct tttatgcaaa aggtttattc cggaaactag tgtacatttc tataaataga 3300
tgctgtgtat atggtatata tacatatata tatataacat atatggaaga ggaaaaggct 3360
ggtacaacgg aggcctgcga ccctgggggc acaggaggca ggcatggccc tgggcggggc 3420
gtgggggggc gtggagggag gccccagggg gtctcaccca tgcaagcaga ggaccagggc 3480
cttttctggc accgcagttt tgttttaaaa ctggacctgt atatttgtaa agctatttat 3540
gggcccctgg cactcttgtt cccacacccc aacacttcca gcatttagct ggccacatgg 3600
cggagagttt taatttttaa cttattgaca accgagaagg tttatcccgc cgatagaggg 3660
acggccaaga atgtacgtcc agcctgcccc ggagctggag gatcccctcc aagcctaaaa 3720
ggttgttaat agttggaggt gattccagtg aagatatttt atttcctttg tcctttttca 3780
ggagaattag atttctatag gatttttctt taggagattt attttttgga cttcaaagca 3840
agctggtatt ttcatacaaa ttcttctaat tgctgtgtgt cccaggcagg gagacggttt 3900
ccagggaggg gccggccctg tgtgcaggtt ccgatgttat tagatgttac aagtttatat 3960
atatctatat atataattta ttgagttttt acaagatgta tttgttgtag acttaacact 4020
tcttacgcaa tgcttctaga gttttatagc ctggactgct acctttcaaa gcttggaggg 4080
aagccgtgaa ttcagttggt tcgttctgta ctgttactgg gccctgagtc tgggcagctg 4140
tcccttgctt gcctgcaggg ccatggctca gggtggtctc ttcttggggc ccagtgcatg 4200
gtggccagag gtgtcaccca aaccggcagg tgcgattttg ttaacccagc gacgaacttt 4260
ccgaaaaata aagacacctg gttgctaacc tggaaaaaaa aaaaaaaaaa 4310
<210> 118
<211> 4310
<212> DNA
<213> Homo sapiens
<400> 118
gtcgcgggca gctggcgccg cgcggtcctg ctctgccggt cgcacggacg caccggcggg 60
ccgccggccg gagggacggg gcgggagctg ggcccgcgga cagcgagccg gagcgggagc 120
cgcgcgtagc gagccgggct ccggcgctcg ccagtctccc gagcggcgcc cgcctcccgc 180
cggtgcccgc gccgggccgt ggggggcagc atgcccgcgc gcgctgcctg aggacgccgc 240
ggcccccgcc cccgccatgg gcgcccctgc ctgcgccctc gcgctctgcg tggccgtggc 300
catcgtggcc ggcgcctcct cggagtcctt ggggacggag cagcgcgtcg tggggcgagc 360
ggcagaagtc ccgggcccag agcccggcca gcaggagcag ttggtcttcg gcagcgggga 420
tgctgtggag ctgagctgtc ccccgcccgg gggtggtccc atggggccca ctgtctgggt 480
caaggatggc acagggctgg tgccctcgga gcgtgtcctg gtggggcccc agcggctgca 540
ggtgctgaat gcctcccacg aggactccgg ggcctacagc tgccggcagc ggctcacgca 600
gcgcgtactg tgccacttca gtgtgcgggt gacagacgct ccatcctcgg gagatgacga 660
agacggggag gacgaggctg aggacacagg tgtggacaca ggggcccctt actggacacg 720
gcccgagcgg atggacaaga agctgctggc cgtgccggcc gccaacaccg tccgcttccg 780
ctgcccagcc gctggcaacc ccactccctc catctcctgg ctgaagaacg gcagggagtt 840
ccgcggcgag caccgcattg gaggcatcaa gctgcggcat cagcagtgga gcctggtcat 900
ggaaagcgtg gtgccctcgg accgcggcaa ctacacctgc gtcgtggaga acaagtttgg 960
cagcatccgg cagacgtaca cgctggacgt gctggagcgc tccccgcacc ggcccatcct 1020
gcaggcgggg ctgccggcca accagacggc ggtgctgggc agcgacgtgg agttccactg 1080
caaggtgtac agtgacgcac agccccacat ccagtggctc aagcacgtgg aggtgaatgg 1140
cagcaaggtg ggcccggacg gcacacccta cgttaccgtg ctcaagtcct ggatcagtga 1200
gagtgtggag gccgacgtgc gcctccgcct ggccaatgtg tcggagcggg acgggggcga 1260
gtacctctgt cgagccacca atttcatagg cgtggccgag aaggcctttt ggctgagcgt 1320
tcacgggccc cgagcagccg aggaggagct ggtggaggct gacgaggcgg gcagtgtgta 1380
tgcaggcatc ctcagctacg gggtgggctt cttcctgttc atcctggtgg tggcggctgt 1440
gacgctctgc cgcctgcgca gcccccccaa gaaaggcctg ggctccccca ccgtgcacaa 1500
gatctcccgc ttcccgctca agcgacaggt gtccctggag tccaacgcgt ccatgagctc 1560
caacacacca ctggtgcgca tcgcaaggct gtcctcaggg gagggcccca cgctggccaa 1620
tgtctccgag ctcgagctgc ctgccgaccc caaatgggag ctgtctcggg cccggctgac 1680
cctgggcaag ccccttgggg agggctgctt cggccaggtg gtcatggcgg aggccatcgg 1740
cattgacaag gaccgggccg ccaagcctgt caccgtagcc gtgaagatgc tgaaagacga 1800
tgccactgac aaggacctgt cggacctggt gtctgagatg gagatgatga agatgatcgg 1860
gaaacacaaa aacatcatca acctgctggg cgcctgcacg cagggcgggc ccctgtacgt 1920
gctggtggag tacgcggcca agggtaacct gcgggagttt ctgcgggcgc ggcggccccc 1980
gggcctggac tactccttcg acacctgcaa gccgcccgag gagcagctca ccttcaagga 2040
cctggtgtcc tgtgcctacc aggtggcccg gggcatggag tacttggcct cccagaagtg 2100
catccacagg gacctggctg cccgcaatgt gctggtgacc gaggacaacg tgatgaagat 2160
cgcagacttc gggctggccc gggacgtgca caacctcgac tactacaaga agacaaccaa 2220
cggccggctg cccgtgaagt ggatggcgcc tgaggccttg tttgaccgag tctacactca 2280
ccagagtgac gtctggtcct ttggggtcct gctctgggag atcttcacgc tggggggctc 2340
cccgtacccc ggcatccctg tggaggagct cttcaagctg ctgaaggagg gccaccgcat 2400
ggacaagccc gccaactgca cacacgacct gtacatgatc atgcgggagt gctggcatgc 2460
cgcgccctcc cagaggccca ccttcaagca gctggtggag gacctggacc gtgtccttac 2520
cgtgacgtcc accgacgagt acctggacct gtcggcgcct ttcgagcagt actccccggg 2580
tggccaggac acccccagct ccagctcctc aggggacgac tccgtgtttg cccacgacct 2640
gctgcccccg gccccaccca gcagtggggg ctcgcggacg tgaagggcca ctggtcccca 2700
acaatgtgag gggtccctag cagcccaccc tgctgctggt gcacagccac tccccggcat 2760
gagactcagt gcagatggag agacagctac acagagcttt ggtctgtgtg tgtgtgtgtg 2820
cgtgtgtgtg tgtgtgtgtg cacatccgcg tgtgcctgtg tgcgtgcgca tcttgcctcc 2880
aggtgcagag gtaccctggg tgtccccgct gctgtgcaac ggtctcctga ctggtgctgc 2940
agcaccgagg ggcctttgtt ctggggggac ccagtgcaga atgtaagtgg gcccacccgg 3000
tgggaccccc gtggggcagg gagctgggcc cgacatggct ccggcctctg cctttgcacc 3060
acgggacatc acagggtggg cctcggcccc tcccacaccc aaagctgagc ctgcagggaa 3120
gccccacatg tccagcacct tgtgcctggg gtgttagtgg caccgcctcc ccacctccag 3180
gctttcccac ttcccaccct gcccctcaga gactgaaatt acgggtacct gaagatggga 3240
gcctttacct tttatgcaaa aggtttattc cggaaactag tgtacatttc tataaataga 3300
tgctgtgtat atggtatata tacatatata tatataacat atatggaaga ggaaaaggct 3360
ggtacaacgg aggcctgcga ccctgggggc acaggaggca ggcatggccc tgggcggggc 3420
gtgggggggc gtggagggag gccccagggg gtctcaccca tgcaagcaga ggaccagggc 3480
cttttctggc accgcagttt tgttttaaaa ctggacctgt atatttgtaa agctatttat 3540
gggcccctgg cactcttgtt cccacacccc aacacttcca gcatttagct ggccacatgg 3600
cggagagttt taatttttaa cttattgaca accgagaagg tttatcccgc cgatagaggg 3660
acggccaaga atgtacgtcc agcctgcccc ggagctggag gatcccctcc aagcctaaaa 3720
ggttgttaat agttggaggt gattccagtg aagatatttt atttcctttg tcctttttca 3780
ggagaattag atttctatag gatttttctt taggagattt attttttgga cttcaaagca 3840
agctggtatt ttcatacaaa ttcttctaat tgctgtgtgt cccaggcagg gagacggttt 3900
ccagggaggg gccggccctg tgtgcaggtt ccgatgttat tagatgttac aagtttatat 3960
atatctatat atataattta ttgagttttt acaagatgta tttgttgtag acttaacact 4020
tcttacgcaa tgcttctaga gttttatagc ctggactgct acctttcaaa gcttggaggg 4080
aagccgtgaa ttcagttggt tcgttctgta ctgttactgg gccctgagtc tgggcagctg 4140
tcccttgctt gcctgcaggg ccatggctca gggtggtctc ttcttggggc ccagtgcatg 4200
gtggccagag gtgtcaccca aaccggcagg tgcgattttg ttaacccagc gacgaacttt 4260
ccgaaaaata aagacacctg gttgctaacc tggaaaaaaa aaaaaaaaaa 4310
<210> 119
<211> 4290
<212> DNA
<213> Homo sapiens
<400> 119
gtcgcgggca gctggcgccg cgcggtcctg ctctgccggt cgcacggacg caccggcggg 60
ccgccggccg gagggacggg gcgggagctg ggcccgcgga cagcgagccg gagcgggagc 120
cgcgcgtagc gagccgggct ccggcgctcg ccagtctccc gagcggcgcc cgcctcccgc 180
cggtgcccgc gccgggccgt ggggggcagc atgcccgcgc gcgctgcctg aggacgccgc 240
ggcccccgcc cccgccatgg gcgcccctgc ctgcgccctc gcgctctgcg tggccgtggc 300
catcgtggcc ggcgcctcct cggagtcctt ggggacggag cagcgcgtcg tggggcgagc 360
ggcagaagtc ccgggcccag agcccggcca gcaggagcag ttggtcttcg gcagcgggga 420
tgctgtggag ctgagctgtc ccccgcccgg gggtggtccc atggggccca ctgtctgggt 480
caaggatggc acagggctgg tgccctcgga gcgtgtcctg gtggggcccc agcggctgca 540
ggtgctgaat gcctcccacg aggactccgg ggcctacagc tgccggcagc ggctcacgca 600
gcgcgtactg tgccacttca gtgtgcgggt gacagacgct ccatcctcgg gagatgacga 660
agacggggag gacgaggctg aggacacagg tgtggacaca ggggcccctt actggacacg 720
gcccgagcgg atggacaaga agctgctggc cgtgccggcc gccaacaccg tccgcttccg 780
ctgcccagcc gctggcaacc ccactccctc catctcctgg ctgaagaacg gcagggagtt 840
ccgcggcgag caccgcattg gaggcatcaa gctgcggcat cagcagtgga gcctggtcat 900
ggaaagcgtg gtgccctcgg accgcggcaa ctacacctgc gtcgtggaga acaagtttgg 960
cagcatccgg cagacgtaca cgctggacgt gctggagcgc tccccgcacc ggcccatcct 1020
gcaggcgggg ctgccggcca accagacggc ggtgctgggc agcgacgtgg agttccactg 1080
caaggtgtac agtgacgcac agccccacat ccagtggctc aagcacgtgg aggtgaatgg 1140
cagcaaggtg ggcccggacg gcacacccta cgttaccgtg ctcaagacgg cgggcgctaa 1200
caccaccgac aaggagctag aggttctctc cttgcacaac gtcacctttg aggacgccgg 1260
ggagtacacc tgcctggcgg gcaattctat tgggttttct catcactctg cgtggctggt 1320
ggtgctgcca gccgaggagg agctggtgga ggctgacgag gcgggcagtg tgtatgcagg 1380
catcctcagc tacggggtgg gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct 1440
ctgccgcctg cgcagccccc ccaagaaagg cctgggctcc cccaccgtgc acaagatctc 1500
ccgcttcccg ctcaagcgac agcaggtgtc cctggagtcc aacgcgtcca tgagctccaa 1560
cacaccactg gtgcgcatcg caaggctgtc ctcaggggag ggccccacgc tggccaatgt 1620
ctccgagctc gagctgcctg ccgaccccaa atgggagctg tctcgggccc ggctgaccct 1680
gggcaagccc cttggggagg gctgcttcgg ccaggtggtc atggcggagg ccatcggcat 1740
tgacaaggac cgggccgcca agcctgtcac cgtagccgtg aagatgctga aagacgatgc 1800
cactgacaag gacctgtcgg acctggtgtc tgagatggag atgatgaaga tgatcgggaa 1860
acacaaaaac atcatcaacc tgctgggcgc ctgcacgcag ggcgggcccc tgtacgtgct 1920
ggtggagtac gcggccaagg gtaacctgcg ggagtttctg cgggcgcggc ggcccccggg 1980
cctggactac tccttcgaca cctgcaagcc gcccgaggag cagctcacct tcaaggacct 2040
ggtgtcctgt gcctaccagg tggcccgggg catggagtac ttggcctccc agaagtgcat 2100
ccacagggac ctggctgccc gcaatgtgct ggtgaccgag gacaacgtga tgaagatcgc 2160
agacttcggg ctggcccggg acgtgcacaa cctcgactac tacaagaaga caaccaacgg 2220
ccggctgccc gtgaagtgga tggcgcctga ggccttgttt gaccgagtct acactcacca 2280
gagtgacgtc tggtcctttg gggtcctgct ctgggagatc ttcacgctgg ggggctcccc 2340
gtaccccggc atccctgtgg aggagctctt caagctgctg aaggagggcc accgcatgga 2400
caagcccgcc aactgcacac acgacctgta catgatcatg cgggagtgct ggcatgccgc 2460
gccctcccag aggcccacct tcaagcagct ggtggaggac ctggaccgtg tccttaccgt 2520
gacgtccacc gacgagtacc tggacctgtc ggcgcctttc gagcagtact ccccgggtgg 2580
ccaggacacc cccagctcca gctcctcagg ggacgactcc gtgtttgccc acgacctgct 2640
gcccccggcc ccacccagca gtgggggctc gcggacgtga agggccactg gtccccaaca 2700
atgtgagggg tccctagcag cccaccctgc tgctggtgca cagccactcc ccggcatgag 2760
actcagtgca gatggagaga cagctacaca gagctttggt ctgtgtgtgt gtgtgtgcgt 2820
gtgtgtgtgt gtgtgtgcac atccgcgtgt gcctgtgtgc gtgcgcatct tgcctccagg 2880
tgcagaggta ccctgggtgt ccccgctgct gtgcaacggt ctcctgactg gtgctgcagc 2940
accgaggggc ctttgttctg gggggaccca gtgcagaatg taagtgggcc cacccggtgg 3000
gacccccgtg gggcagggag ctgggcccga catggctccg gcctctgcct ttgcaccacg 3060
ggacatcaca gggtgggcct cggcccctcc cacacccaaa gctgagcctg cagggaagcc 3120
ccacatgtcc agcaccttgt gcctggggtg ttagtggcac cgcctcccca cctccaggct 3180
ttcccacttc ccaccctgcc cctcagagac tgaaattacg ggtacctgaa gatgggagcc 3240
tttacctttt atgcaaaagg tttattccgg aaactagtgt acatttctat aaatagatgc 3300
tgtgtatatg gtatatatac atatatatat ataacatata tggaagagga aaaggctggt 3360
acaacggagg cctgcgaccc tgggggcaca ggaggcaggc atggccctgg gcggggcgtg 3420
ggggggcgtg gagggaggcc ccagggggtc tcacccatgc aagcagagga ccagggcctt 3480
ttctggcacc gcagttttgt tttaaaactg gacctgtata tttgtaaagc tatttatggg 3540
cccctggcac tcttgttccc acaccccaac acttccagca tttagctggc cacatggcgg 3600
agagttttaa tttttaactt attgacaacc gagaaggttt atcccgccga tagagggacg 3660
gccaagaatg tacgtccagc ctgccccgga gctggaggat cccctccaag cctaaaaggt 3720
tgttaatagt tggaggtgat tccagtgaag atattttatt tcctttgtcc tttttcagga 3780
gaattagatt tctataggat ttttctttag gagatttatt ttttggactt caaagcaagc 3840
tggtattttc atacaaattc ttctaattgc tgtgtgtccc aggcagggag acggtttcca 3900
gggaggggcc ggccctgtgt gcaggttccg atgttattag atgttacaag tttatatata 3960
tctatatata taatttattg agtttttaca agatgtattt gttgtagact taacacttct 4020
tacgcaatgc ttctagagtt ttatagcctg gactgctacc tttcaaagct tggagggaag 4080
ccgtgaattc agttggttcg ttctgtactg ttactgggcc ctgagtctgg gcagctgtcc 4140
cttgcttgcc tgcagggcca tggctcaggg tggtctcttc ttggggccca gtgcatggtg 4200
gccagaggtg tcacccaaac cggcaggtgc gattttgtta acccagcgac gaactttccg 4260
aaaaataaag acacctggtt gctaacctgg 4290
<210> 120
<211> 4219
<212> DNA
<213> Homo sapiens
<400> 120
gtcgcgggca gctggcgccg cgcggtcctg ctctgccggt cgcacggacg caccggcggg 60
ccgccggccg gagggacggg gcgggagctg ggcccgcgga cagcgagccg gagcgggagc 120
cgcgcgtagc gagccgggct ccggcgctcg ccagtctccc gagcggcgcc cgcctcccgc 180
cggtgcccgc gccgggccgt ggggggcagc atgcccgcgc gcgctgcctg aggacgccgc 240
ggcccccgcc cccgccatgg gcgcccctgc ctgcgccctc gcgctctgcg tggccgtggc 300
catcgtggcc ggcgcctcct cggagtcctt ggggacggag cagcgcgtcg tggggcgagc 360
ggcagaagtc ccgggcccag agcccggcca gcaggagcag ttggtcttcg gcagcgggga 420
tgctgtggag ctgagctgtc ccccgcccgg gggtggtccc atggggccca ctgtctgggt 480
caaggatggc acagggctgg tgccctcgga gcgtgtcctg gtggggcccc agcggctgca 540
ggtgctgaat gcctcccacg aggactccgg ggcctacagc tgccggcagc ggctcacgca 600
gcgcgtactg tgccacttca gtgtgcgggt gacagacgct ccatcctcgg gagatgacga 660
agacggggag gacgaggctg aggacacagg tgtggacaca ggggcccctt actggacacg 720
gcccgagcgg atggacaaga agctgctggc cgtgccggcc gccaacaccg tccgcttccg 780
ctgcccagcc gctggcaacc ccactccctc catctcctgg ctgaagaacg gcagggagtt 840
ccgcggcgag caccgcattg gaggcatcaa gctgcggcat cagcagtgga gcctggtcat 900
ggaaagcgtg gtgccctcgg accgcggcaa ctacacctgc gtcgtggaga acaagtttgg 960
cagcatccgg cagacgtaca cgctggacgt gctggagcgc tccccgcacc ggcccatcct 1020
gcaggcgggg ctgccggcca accagacggc ggtgctgggc agcgacgtgg agttccactg 1080
caaggtgtac agtgacgcac agccccacat ccagtggctc aagcacgtgg aggtgaatgg 1140
cagcaaggtg ggcccggacg gcacacccta cgttaccgtg ctcaagacgg cgggcgctaa 1200
caccaccgac aaggagctag aggttctctc cttgcacaac gtcacctttg aggacgccgg 1260
ggagtacacc tgcctggcgg gcaattctat tgggttttct catcactctg cgtggctggt 1320
ggtgctgcca gccgaggagg agctggtgga ggctgacgag gcgggcagtg tgtatgcagg 1380
catcctcagc tacggggtgg gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct 1440
ctgccgcctg cgcagccccc ccaagaaagg cctgggctcc cccaccgtgc acaagatctc 1500
ccgcttcccg ctcaagcgac agcaggtgtc cctggagtcc aacgcgtcca tgagctccaa 1560
cacaccactg gtgcgcatcg caaggctgtc ctcaggggag ggccccacgc tggccaatgt 1620
ctccgagctc gagctgcctg ccgaccccaa atgggagctg tctcgggccc ggctgaccct 1680
gggcaagccc cttggggagg gctgcttcgg ccaggtggtc atggcggagg ccatcggcat 1740
tgacaaggac cgggccgcca agcctgtcac cgtagccgtg aagatgctga aagacgatgc 1800
cactgacaag gacctgtcgg acctggtgtc tgagatggag atgatgaaga tgatcgggaa 1860
acacaaaaac atcatcaacc tgctgggcgc ctgcacgcag ggcgggcccc tgtacgtgct 1920
ggtggagtac gcggccaagg gtaacctgcg ggagtttctg cgggcgcggc ggcccccggg 1980
cctggactac tccttcgaca cctgcaagcc gcccgaggag cagctcacct tcaaggacct 2040
ggtgtcctgt gcctaccagg tggcccgggg catggagtac ttggcctccc agaagtgcat 2100
ccacagggac ctggctgccc gcaatgtgct ggtgaccgag gacaacgtga tgaagatcgc 2160
agacttcggg ctggcccggg acgtgcacaa cctcgactac tacaagaaga caaccaacct 2220
ggtcctttgg ggtcctgctc tgggagatct tcacgctggg gggctccccg taccccggca 2280
tccctgtgga ggagctcttc aagctgctga aggagggcca ccgcatggac aagcccgcca 2340
actgcacaca cgacctgtac atgatcatgc gggagtgctg gcatgccgcg ccctcccaga 2400
ggcccacctt caagcagctg gtggaggacc tggaccgtgt ccttaccgtg acgtccaccg 2460
acgagtacct ggacctgtcg gcgcctttcg agcagtactc cccgggtggc caggacaccc 2520
ccagctccag ctcctcaggg gacgactccg tgtttgccca cgacctgctg cccccggccc 2580
cacccagcag tgggggctcg cggacgtgaa gggccactgg tccccaacaa tgtgaggggt 2640
ccctagcagc ccaccctgct gctggtgcac agccactccc cggcatgaga ctcagtgcag 2700
atggagagac agctacacag agctttggtc tgtgtgtgtg tgtgtgcgtg tgtgtgtgtg 2760
tgtgtgcaca tccgcgtgtg cctgtgtgcg tgcgcatctt gcctccaggt gcagaggtac 2820
cctgggtgtc cccgctgctg tgcaacggtc tcctgactgg tgctgcagca ccgaggggcc 2880
tttgttctgg ggggacccag tgcagaatgt aagtgggccc acccggtggg acccccgtgg 2940
ggcagggagc tgggcccgac atggctccgg cctctgcctt tgcaccacgg gacatcacag 3000
ggtgggcctc ggcccctccc acacccaaag ctgagcctgc agggaagccc cacatgtcca 3060
gcaccttgtg cctggggtgt tagtggcacc gcctccccac ctccaggctt tcccacttcc 3120
caccctgccc ctcagagact gaaattacgg gtacctgaag atgggagcct ttacctttta 3180
tgcaaaaggt ttattccgga aactagtgta catttctata aatagatgct gtgtatatgg 3240
tatatataca tatatatata taacatatat ggaagaggaa aaggctggta caacggaggc 3300
ctgcgaccct gggggcacag gaggcaggca tggccctggg cggggcgtgg gggggcgtgg 3360
agggaggccc cagggggtct cacccatgca agcagaggac cagggccttt tctggcaccg 3420
cagttttgtt ttaaaactgg acctgtatat ttgtaaagct atttatgggc ccctggcact 3480
cttgttccca caccccaaca cttccagcat ttagctggcc acatggcgga gagttttaat 3540
ttttaactta ttgacaaccg agaaggttta tcccgccgat agagggacgg ccaagaatgt 3600
acgtccagcc tgccccggag ctggaggatc ccctccaagc ctaaaaggtt gttaatagtt 3660
ggaggtgatt ccagtgaaga tattttattt cctttgtcct ttttcaggag aattagattt 3720
ctataggatt tttctttagg agatttattt tttggacttc aaagcaagct ggtattttca 3780
tacaaattct tctaattgct gtgtgtccca ggcagggaga cggtttccag ggaggggccg 3840
gccctgtgtg caggttccga tgttattaga tgttacaagt ttatatatat ctatatatat 3900
aatttattga gtttttacaa gatgtatttg ttgtagactt aacacttctt acgcaatgct 3960
tctagagttt tatagcctgg actgctacct ttcaaagctt ggagggaagc cgtgaattca 4020
gttggttcgt tctgtactgt tactgggccc tgagtctggg cagctgtccc ttgcttgcct 4080
gcagggccat ggctcagggt ggtctcttct tggggcccag tgcatggtgg ccagaggtgt 4140
cacccaaacc ggcaggtgcg attttgttaa cccagcgacg aactttccga aaaataaaga 4200
cacctggttg ctaacctgg 4219
<210> 121
<211> 15574
<212> DNA
<213> Homo sapiens
<400> 121
cggtggcggc ggcgtcgcgg gcagctggcg ccgcgcggtc ctgctctgcc ggtcgcacgg 60
acgcaccggc gggccgccgg ccggagggac ggggcgggag ctgggcccgc ggacagcgag 120
ccggagcggg agccgcgcgt agcgagccgg gctccggcgc tcgccaggtc cgtgcttggg 180
gccgggcagg ctcgcggagg ggtccaacgg tgctcgcgga ggggtcgggg cgcggctgtc 240
gcggaaccac agaggtccct gcagcgggcc gggccggggc gcgggcttcc cgctccggaa 300
agtttgccgc cgccgccgcc ctgggagggc tttgcagcag ccagggaggg aagggggagg 360
agggagggac cgcggcgggg aggaggcggc cggcgccagg cggcccggga gccctgggcg 420
gcggcggcgg cgggcggggc ggctgggggt cggaggggtc gggacgcagg agccggccac 480
cgccgctttc gtccctgtcc gcccctctaa cgagctgcct tcctcctcct gtagtctccc 540
gagcggcgcc cgcctcccgc cggtgcccgc gccgggccgt ggggggcagc atgcccgcgc 600
gcgctgcctg aggacgccgc ggcccccgcc cccgccatgg gcgcccctgc ctgcgccctc 660
gcgctctgcg tggccgtggc catcgtggcc ggcgcctcct cggagtcctt ggggacggag 720
cagcgcgtcg tggggcgagc ggcaggtaag aagggaccca ctaggcacgg gagaggccgg 780
cccgtgcggg cagaggcgtt ggggacggga accggccccg ggtcggaggg gccgccgggt 840
gtgagtgacg ccccggggtt agagcccgga ttccgctgcc tccttgccgg agagcgcggc 900
cagagctagc gcggcgactt gtggtgcgcc cggagccgca gctaccctcc aagtgcgagg 960
ccaccacggg gagccaggct gggggttggc gtccgcagcc ccgatcccct gcgactccct 1020
agccctggcc tgtcgggagg gcgcgggggg ccccatttcc acgattcccg ctgttgttat 1080
tcgggttctg cgcagacgga aagttcccat tgttggcgtc cccctccccc gggccccagt 1140
ttgtggccag cttcggccaa ggcgagagac cggacttcta agggtgggtg tgcgcgtcag 1200
cgaagcccgg cccctgcccg cccgaagagg cagcagcctc cagcgtcccc gctgccgacc 1260
ctgcccctgc ctgggggccg agggcgcttc cccgtgggtg cgcgccgagc tccaggcaag 1320
cgaggggcgc gtgtcccagc gtcgcgggcc ctagactggg ctggcggtcc aggtcccgcg 1380
ggacgtcgag ggtctgaagg gaggtcccaa ggggcgaggg gaggggaagg ggcgcccggc 1440
cggacctgca cacgcgccgc ggttcctcgt gggccgggcc gagagctccg gtgccgccgc 1500
cgcgtacacc cgcagccggc tccggacggg cgaggggggc gcgcacagct cagcccggcg 1560
gccgcgcgga gggaggcctt ggcccggtga gctcgcgccc cacccgggcc gaggcccgaa 1620
cagccgcttc tttgtacctc gacgcggcca cagaccgcgc attgatggcg gctcggcggc 1680
tcgcggggag gtgtgagcga ccgcgggcgc ggcgggccgg ggagggcgcc tggagggccg 1740
aggcagatgg cgtccgcccc gcccgcgccc ccgcgcccct ttctccgtcg gcggctgcag 1800
cctcccggaa caatgtcatt ttttttatga atgaaagtgg cccggcgctt gaatgtgcgt 1860
gtcattcagc ggcgtgacag gggccgtcgg gaggtcagcg cgcgctttta gcgtctgctc 1920
gggcggcccc gcttccaggg gtgccggagg ggcggccgcg gggggagctt ggctttcgca 1980
ttctcattca gataaagata ttactcccta cggcccggga atgtcagcca gccccgggga 2040
agggcggcgg ccaggctgcg gagcctctcc tggaccccct gcgggcgcgc ggggcctccc 2100
ccagtcgctc ctggaacgcc ccgcccaccc ctcccccggg gcggcgcccc cgcccgcact 2160
ggagctggtg aaacaggtag tgagttgatc ggtcaataaa cttaatccgg ttccttaaca 2220
agatgggccg ggcagtaaaa atacaaagac ctcgtgaaat ggactgaggt ctaggctggc 2280
gcttgcccgg gaacataaat tatggagcct tggctcgcag gggtcaaggg cggtgggaaa 2340
ggttttggcc actggactgc cctggccacc ccaggccctg ccaggacagc ccccatctcc 2400
ccagggggcc gtattcctgg ttgggacctg gagtgacccc ccagggtgca gggaggtaca 2460
caaggtcggc tctcccacag tcccacccca cccagcaggg gtctgggggt gcagggcctt 2520
tcccgaaggt gctggctgca acctccccca ctcctcctct gcagggctgg actttgagcc 2580
gcgtgggcct ctgggtggtt cattaacctg ggctgagcct ggcctccagg tccttgtgtg 2640
agcctaggaa ccccttgtta cccacccccc agctccccag ccctcaggtc tcacttgggg 2700
ctagatctgg ggctgtggca ccccttgtta cagctgagct tgagtgggag cccaggggct 2760
tggggtctcc tggaggacgg ggatctaaag tcacctcatc tagggaggca tgcagccctc 2820
acctgagtga ttcaggagtg aatgagccag gagtggagcc acctttggtg gggtaggggt 2880
cagcctggac ctctaggctg ccagctcagg ctcgggtgcc ctcttcgaac ctcagtttcc 2940
ttacctgtcc aagagaaccg ataatggcag gctgtttgaa ggattaggcc agataaccct 3000
ggcaagccct ctttagcctg cccagcctcc agatcccttt tttccggact ttattgtgaa 3060
actccaggtg gggagacagg gaggctggac ttttgggggc cccctcctct taggctattt 3120
tatagctcct acctggcaat acctcctgta ccccagagag ctgcagagaa cttcatgtgc 3180
atccgaaacc agaatgtgtt gtttcctgac cccaggccct catctcaccc caaaacccaa 3240
ataaacccct ggggcagcca gctccggaag cgagtctgga tttgatcctt gttctctggg 3300
gtcaacccga ggggcttatg atggagcaag gctcccccat cctctcagcc atgctccctc 3360
acatgcactg ggcctccact gcagagaccc agagcctgga gaaaggttcc ccaggccaga 3420
gtttggccgt ccccagcacc ctgcctaatg gacatcagtc ttggggccag agacccaggg 3480
cagggagcgc ctctcacccc taccctcact cctgcagcca tttcagggcc tggtgccctc 3540
cctgagctcc tgggcctgtg gggtgggatt tttactttgt gccacagtgg gggaaactga 3600
ggtacaggac cagtgagtgg cagagttgtg gagactctgg gacacagcag agggctgtcg 3660
ttggcatgtg gagcccaagt tgaggtcggc actgtgtggg gttggggcgc cggcaggagc 3720
acgtgttgtg ggatccatag aagggtggga ggtgggacgc gttgcctcct accccgcctt 3780
gggtacagca ggagttttgt ctccaacgtg tttgggcacc agtgtctgtg tggtgtcagt 3840
ggggcctccc ttttgtggat caagaaagaa agaacccttc ctagggctgc tggggggcta 3900
tagctctccc catgcctggc agctgggtgg ggtatggggg ctccacccaa ctgctgactt 3960
cccagtggga gtcagaccct gaacttatag cacccactca tgccccgtgt cacactgtcc 4020
ttcacctggt gctcgccacc cagcccctgc tggggtaccc tggcctctgc tggcacctag 4080
caggcaggca gtgggggggg cagtcagggc tgcaccctcc ccaccacaca cgggcagatg 4140
gccactggtg tggctggcct ggggctgctg tgtcccccgt ccccccgtgc tggaccaggc 4200
tgaagcaaat acttgtgtgg atggcttgac ctgttgtcgc cactcagacc aaaccggaac 4260
caaccggctg ttgcccttgg gccagggcct gcagctgagg ctgccataac cagcctgttc 4320
tcggccttct ggggggcctc gagcagctcc cagctctggg tggtccccac aagacactgg 4380
ccaggaccgg agggctggag gtcaggccag gagcccccct gactgcgggg tccctacagg 4440
ggcagtcctt gagctgtggg tcccggtggg gcgagggctc cttcggatgc ttcaggggat 4500
gagtgtgggc ccttctggct ggcagggtca ccctgggcac taggcgtgtg tggctggatc 4560
aggtgggttg ggcagaagag ggcctggccg ggcagccagg gactggtgtg gccagagtgg 4620
gcagctgggc ccccgaatct aggccacgcg tctgcagaat gacaagtgat ggcgcaaccc 4680
gcccagctgg gtctgaagaa ggaggctgcc tgggggacca cccacccccg tcccggcccc 4740
aagcccggga cgcctgcctg catgcattgt ctggccctgg cagggaagcc taggggcgat 4800
tgtcccccca gccctgccca tggtgtgtcc ttgggtcaca ggctttggtg gctctgggga 4860
gctgggcagc tactggggag ggacccaggg gccacctgca catctgcccc tgtgggtggg 4920
cccccacccc agcttctcag cccccaggga ggggccaggg ctgctgacct gccctggctc 4980
tcacagcttc ctgcccccag cctggtcgtc ctctgtgagg gggccccagt ccccctgcag 5040
gcagcaggac tccacccccc ggcccccttg agggcccgcc tgggcctccc cactccccgg 5100
cctgtgagac ccacttggcc ggacccagcg ccgtgtttgt actttgctct tctcggtatg 5160
ttttccgtca tgaccgccgt gtggagcttc cataggagct gcaggataca gaaccttgcc 5220
caccccaagg agcccccacc cccgccccgg ccccctcgcg ctgctccggc ctgtgctctg 5280
accggtgaac ccgcgcatcg ccccccagac cgtccacacg gccacgtgac cctgcacctc 5340
cttccttctc gcctgttctg ttccctggct gtccatctga actgcttttc aggctcatat 5400
ggggtgcggg ggctactgag gacggacccc tcctggggtg aatctgcacc acgagggggc 5460
tggctggcca accctggcac cccctctgag ctccatttca gtcagaggcc agcaaagggc 5520
agcctgtccc ctttgcccgc agcacctgcc cgtcgtggtg ccgcctgtga gacaagcatg 5580
gattttatgt ttccaagcaa ttgaacaaat taaaagaacg aagagtcaca ttttgtgaca 5640
ctttgagatt tgaattctcc gtgtccatga gtgaagcatc atggggccac tgctgtgggg 5700
ttggctgcag gttgtgtggg gaaggcggct gtcacaccga ggcagaccgg agtccttggg 5760
acagactggt tggcaaagct gaagatagag acctttggcc cttttgggac acagtttcca 5820
gcccctggtc tggtgggacc ctggatctgg gtcagagcct tcctcactca gggccgccga 5880
ggcttccact gctgtgtctg taaacggtgc cgggtttggg ggtgcctgcc tcatggttgc 5940
ccatcttccc cacagaagtc ccgggcccag agcccggcca gcaggagcag ttggtcttcg 6000
gcagcgggga tgctgtggag ctgagctgtc ccccgcccgg gggtggtccc atggggccca 6060
ctgtctgggt caaggatggc acagggctgg tgccctcgga gcgtgtcctg gtggggcccc 6120
agcggctgca ggtgctgaat gcctcccacg aggactccgg ggcctacagc tgccggcagc 6180
ggctcacgca gcgcgtactg tgccacttca gtgtgcgggt gacaggtgag ctctggggcc 6240
acgccagcta cagaaaggag ccgagtgccg ggctccctga gtccctgcgt gggtcaggag 6300
cggctggggg tctctctggt cattggtgga gaggagggca cccccaggaa gtgctgccca 6360
aatgggggac cctgccccat ctgggagggg cacctggggg cctcctgggg caggttgggc 6420
attggttgcg gccatctctg ccttgcagac gctccatcct cgggagatga cgaagacggg 6480
gaggacgagg ctgaggacac aggtgtggac acaggtagga gcagggtcca gggttcaggc 6540
cagccggggt ggggcccgct gccaccgcca agccctgccc ttcacaggca gctgagggac 6600
taaggccccg gaacaacctc cctggggtca ccccgaaggt ctggtcccct caggatacag 6660
gaggggctgg gtcactgaca tggctctaga tgccccaccc tggtggcagg gctggggtgc 6720
aaggggacac cgtgttgctg atggggagac tgaggcacag ggccctgggg gttccaggag 6780
caggaggagg ccagggctgg cctgtggggc tctggtgttg gctataggtg aggtggaccc 6840
cgcagacatt agcgcagcag ggcagggcac tcaggtggct gccgtggggt ggatggaccc 6900
ggggtgaggg cgccggggca cctgccacaa ccagtggcgg gcagggtggc tggcaggagg 6960
gtggctggtg ggtgggctgc ggctgtgaga gagcagtcgg ggacgatgcc tggcgtcccg 7020
gcctggaacg gtggcaggtg gactttgcca agttgtaggg tggggaggtg gggcttctgg 7080
ttttggaggg agctctgagg ggagtgcgtg caggtgaggg tcatcgtggc acagacatgg 7140
ggggcagtta cgacttgcgg actgatggtg tgtgcgctgg gtccctgggc cagtggggta 7200
agcaggtgag gaagggaggc tgagtccatg agagaaacag ctgggggaac tcaccctggg 7260
ggtctccagg aggcctggga gggagctcag caccgtgggg tgcctctttc cagcctgtgt 7320
ccacactgct gcttgctggg cctcagtgcc cctgatgggc gtgtgcctgg agggggctgg 7380
cagtgagctc actgagggga gggctgcttc cctcctgggg aatgccagcc catccttgcc 7440
tggagtcccg gcaggaaggc agcaccagcc ctgaggaagg agaaaaacca gttgggctgt 7500
gagaggggtg gtgggagccc tggacatcga gatgggagga ggcagggcct ccagggtgcc 7560
accgtctctg ggtgcccgcc agacttggag ctctgcagag ggtggtgtag ggtcttgatt 7620
tccgtgggcc catgctgccc agctgcctcc aaggctcctg gctctgcagg cgactgggct 7680
cctctcctgg taaactgctc ccaggtcctg gcttgtccac tagatgggcc tgccccctgg 7740
gtcttcagtc tccccgttgg tgggcctggc cctggcacgc ctctctgggc aggtgggctc 7800
ccctggacaa tgccctgtgc cctgtgactt cacaggtccg ggcagagcac cctggagggg 7860
aggggagggg acacacggcc cagctctgag aaagccccgg ggaggggaca agatgtggag 7920
gctcctggga acctcatccc gccctcttcc tacacaggac gggaaactga ggctggggat 7980
gggcaggggc agctctggga agggggttgt tcagaggggc ctctgctccc actcgggtca 8040
tggccttcac acgcacctcg gcccgcaggg gccccttact ggacacggcc cgagcggatg 8100
gacaagaagc tgctggccgt gccggccgcc aacaccgtcc gcttccgctg cccagccgct 8160
ggcaacccca ctccctccat ctcctggctg aagaacggca gggagttccg cggcgagcac 8220
cgcattggag gcatcaaggt gggcgcggcg gggtggctct gggcctggca ggcgcggtgg 8280
ttgctgcctc cgctcactca cccgcccgcg tcccggtgca gctgcggcat cagcagtgga 8340
gcctggtcat ggaaagcgtg gtgccctcgg accgcggcaa ctacacctgc gtcgtggaga 8400
acaagtttgg cagcatccgg cagacgtaca cgctggacgt gctgggtgag ggccctgggg 8460
cggcgcgggg gtgggggcgg cagtggcggt ggtggtgagg gagggggtgg cccctgagcg 8520
tcatctgccc ccacagagcg ctccccgcac cggcccatcc tgcaggcggg gctgccggcc 8580
aaccagacgg cggtgctggg cagcgacgtg gagttccact gcaaggtgta cagtgacgca 8640
cagccccaca tccagtggct caagcacgtg gaggtgaatg gcagcaaggt gggcccggac 8700
ggcacaccct acgttaccgt gctcaaggtg ggccaccgtg tgcacgtggg tgccgccgct 8760
ggggctcctg ggctggcccc aagggtgccc cttggctgcg ggttgcgtga ggatttgggt 8820
ctaggggttg gagcttcggg ggcagaagct gtgggggtgc ttgtggggcc aagtctcagc 8880
caccccacac ctcagggcca taggcagctg cgttgggacc cgtttccgtg tctgcagagg 8940
gccagcctca gccactgaag tccctgacat ggagctgccc acgggcttct tgggggtggg 9000
tgcggcttgg gcagcagtgg tgccccagga caggagggca gtgtggccaa gccctccagg 9060
ccccctctgg gcctcagagg cggtggctga gccccgacct ggccgattgg ctctcgtcag 9120
ctgtgtgcag tggggcccga gctcactgtc tgcccgcctc ctgaagccct tagctttgtt 9180
cccatggctg ccgggtgggg gccactgaat tgggacggtt gcgacactca aagcccaaag 9240
agaaacatct gttcagagag aagacggtct cttgggggcg gggagcaggc gcagggcgag 9300
ggtggagtcc agaccccgcc cagagaggcc gcctcgggcc ctgtccaggg tgcaggttct 9360
gcaagagccc gggggagggc aggccagtga ccagaggttg tctgagggtc tgggctgggt 9420
tgttggggtg gaggcagaga cgtgcatcct gtgaaaccac agccaccgtg aagtgcctcc 9480
acgcctcctc caggcagcct ttggggctga cgcagcccag cctcgatctg taccttgggg 9540
gtctcccaca tcctgcctcg tgcccggcgg ggctgcctcg ggggcgtgcc tgagccgggt 9600
ctcttgtccc cgcagtcctg gatcagtgag agtgtggagg ccgacgtgcg cctccgcctg 9660
gccaatgtgt cggagcggga cgggggcgag tacctctgtc gagccaccaa tttcataggc 9720
gtggccgaga aggccttttg gctgagcgtt cacgggcccc gagcaggtaa cgactctgtc 9780
ccatgccggc cggcacaaga gctccagctc caaggccctg gccgcgcgcc ctgcacgccc 9840
cgcacgccca gccctgctcg ctcccgcccc ggctcgcgct ccactcgggg ccgcctcggc 9900
aaggctggca gctccagcct ccacggtgac cgcccgcttc gagccctgtg gcctgcgccg 9960
acccttcccg cacgcctgcg acccccacag gaggtgcccg gtgcccaccg ggccggctcc 10020
gtgccgtctg tgagcacccc tttgcgcctc tctccacccc tgcccgctgc ctgctcgctt 10080
ccgcagcctg tgtgtccctg tgtccatcct ccacctgcac ccgcccggct ctgcgctaac 10140
ccgcatgctg cctgcccgcc tgccgctcac ctgggacaga ggactcgccg gtggaggggc 10200
ctggcttcgg gctcagtacc ggtgtaccag gcggagggcc ctcagccgcg tggcggtgac 10260
caagttggcg gtggctgagg agttggtggt ggcggcgttt tccttgcagc ggctggatcc 10320
tgccgtgtgg actctgtgcg gtgcccgcag ggcggtgctg gcgctcgcct atcgctctgc 10380
tctctctttg tagacggcgg gcgctaacac caccgacaag gagctagagg ttctctcctt 10440
gcacaacgtc acctttgagg acgccgggga gtacacctgc ctggcgggca attctattgg 10500
gttttctcat cactctgcgt ggctggtggt gctgccaggt accggcttct gctgctgctg 10560
ctgctccgca ctgtctgggg gacgctggct cgggacacgc caaagctgcc aggacggacg 10620
ggaatcctgt gacttacggc cgtcccgctt cttgagccct cactcctggc cctgtgccca 10680
gtgtggggac aaagttggcc tggcccggtc ctggtcccag aggggccccc tcagccccct 10740
cgagcccact tcccatctgg gtccccaaag gcctctcctg tggctctggt gtctcccggg 10800
cgcctggtgg cggtgtggga ctggctggct ctgctgggct ccttctctcc agggtctggc 10860
cctctagact cactggcgtt actgactgcg agaccctcca gacaaggcgc gtgctgaggt 10920
tctgagcccc cttccgctcc cagtggtgcc tgcggctctg ggccaggggc atccatggga 10980
gccccgtggg ggggggggcc aggccaggcc tcaacgccca tgtctttgca gccgaggagg 11040
agctggtgga ggctgacgag gcgggcagtg tgtatgcagg catcctcagc tacggggtgg 11100
gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct ctgccgcctg cgcagccccc 11160
ccaagaaagg cctgggctcc cccaccgtgc acaagatctc ccgcttcccg ctcaagcgac 11220
aggtaacaga aagtagatac caggttctga gctgcctgcc cgccaggcct cctggagccc 11280
cacctcggcc cacgctggtc ctgggctgtg tgagccctct ctgcagccag gcgggctccc 11340
ctctcctcgt ctctgctcac catgtagagc ctagggtact ttggggcacg aaacattcta 11400
aaaatcttca ttcaatgctg gtggaagtca gaacgccccc ccttctggcc cagcactgac 11460
ccccggctgt acctccacgc cctgtcgccc acgcggcgcc aacctgcccc tgctgaccca 11520
agcaggtgtc cctggagtcc aacgcgtcca tgagctccaa cacaccactg gtgcgcatcg 11580
caaggctgtc ctcaggggag ggccccacgc tggccaatgt ctccgagctc gagctgcctg 11640
ccgaccccaa atgggagctg tctcgggccc ggtcagtggt gctgagggcc agcgttggct 11700
gtagggggct tggtggtggg ggtgaaacag ccaccagtca gaggcccggc tgggtttagg 11760
ggccgtcagg gatgtggcgg atgttgggtg tggctggggt tctgtggaga tgctcctggg 11820
acgggtgtat ggcagggact gcccctctca aggtgccctg tctggagggg cagcaagggc 11880
gggaggctgt gggtgacact cttcgtcctt acgagcaggc tgtaggggga gcatggaggg 11940
cttcctggag gtggtggctc tgggcctcaa gggctgggcc aggctggggt ggggaccgtg 12000
gtgggctgag agtgggcgag tttgcacact catggtccct ctgcctccac tgccaggctg 12060
accctgggca agccccttgg ggagggctgc ttcggccagg tggtcatggc ggaggccatc 12120
ggcattgaca aggaccgggc cgccaagcct gtcaccgtag ccgtgaagat gctgaaaggt 12180
gaggaggggg cggccagggg tgcagagcag ggctgggggc gccgccgccg cctgacacag 12240
gccccccgct ccgtgcacag acgatgccac tgacaaggac ctgtcggacc tggtgtctga 12300
gatggagatg atgaagatga tcgggaaaca caaaaacatc atcaacctgc tgggcgcctg 12360
cacgcagggc ggtaggtgcg gtagcggcgg tggtgccggc tgggcggccc tcctgggcct 12420
ggcagcccgt ctgaggagcc cgtgtcccca gggcccctgt acgtgctggt ggagtacgcg 12480
gccaagggta acctgcggga gtttctgcgg gcgcggcggc ccccgggcct ggactactcc 12540
ttcgacacct gcaagccgcc cgaggagcag ctcaccttca aggacctggt gtcctgtgcc 12600
taccaggtgg cccggggcat ggagtacttg gcctcccaga aggtgggcag ggcggcaggt 12660
gtgggtggag taggctgggc cctgccctga gatgctggga gcagcgggga gaggtggaga 12720
ggcttcagcc ctgcctccca ccccttcccc agtgcatcca cagggacctg gctgcccgca 12780
atgtgctggt gaccgaggac aacgtgatga agatcgcaga cttcgggctg gcccgggacg 12840
tgcacaacct cgactactac aagaagacga ccaacgtgag cccggccctg gggtgcgggg 12900
gtgggggtca tgccagtagg acgcctggcg ccaacaccgc cttcccacac cctcccaggg 12960
ccggctgccc gtgaagtgga tggcgcctga ggccttgttt gaccgagtct acactcacca 13020
gagtgacgtg tacgtgtcct gcagagctca ggcttcaggg gtggaggcgg gaactgggca 13080
gagccaggac cccagctgca gtccccaggc ctgtgccctg gagctcctgg gtgtggtttc 13140
tacccctccc tgggggcagc agcgcagccc tggcctattc ccctggtgcc cgcccaggtg 13200
tctgtcctgg gagtctcagg acagcctgac ctcaccttcc cctgcagctg gtcctttggg 13260
gtcctgctct gggagatctt cacgctgggg ggctccccgt accccggcat ccctgtggag 13320
gagctcttca agctgctgaa ggagggccac cgcatggaca agcccgccaa ctgcacacac 13380
gacctgtgag tggcatccct ggccctccac tgggtcctca ggggtggggg tccctccggg 13440
gctgggcggg ggagggactg gcagcccttc aggctgttcc cgaataaggc gggaagcggc 13500
ggggctcact cctgagcgcc ctgcccgcag gtacatgatc atgcgggagt gctggcatgc 13560
cgcgccctcc cagaggccca ccttcaagca gctggtggag gacctggacc gtgtccttac 13620
cgtgacgtcc accgacgtga gtgctggctc tggcctggtg ccacccgcct atgcccctcc 13680
ccctgccgtc cccggccatc ctgcccccca gagtgctgag gtgtggggcg ggccttctgg 13740
ggcacagcct gggcacagag gtggctgtgc gaagaggggc tcggtggcac agcgctcacc 13800
ccgcctcccg ccagcaggag tacctggacc tgtcggcgcc tttcgagcag tactccccgg 13860
gtggccagga cacccccagc tccagctcct caggggacga ctccgtgttt gcccacgacc 13920
tgctgccccc ggccccaccc agcagtgggg gctcgcggac gtgaagggcc actggtcccc 13980
aacaatgtga ggggtcccta gcagcccacc ctgctgctgg tgcacagcca ctccccggca 14040
tgagactcag tgcagatgga gagacagcta cacagagctt tggtctgtgt gtgtgtgtgt 14100
gcgtgtgtgt gtgtgtgtgt gcacatccgc gtgtgcctgt gtgcgtgcgc atcttgcctc 14160
caggtgcaga ggtaccctgg gtgtccccgc tgctgtgcaa cggtctcctg actggtgctg 14220
cagcaccgag gggcctttgt tctgggggga cccagtgcag aatgtaagtg ggcccacccg 14280
gtgggacccc cgtggggcag ggagctgggc ccgacatggc tccggcctct gcctttgcac 14340
cacgggacat cacagggtgg gcctcggccc ctcccacacc caaagctgag cctgcaggga 14400
agccccacat gtccagcacc ttgtgcctgg ggtgttagtg gcaccgcctc cccacctcca 14460
ggctttccca cttcccaccc tgcccctcag agactgaaat tacgggtacc tgaagatggg 14520
agcctttacc ttttatgcaa aaggtttatt ccggaaacta gtgtacattt ctataaatag 14580
atgctgtgta tatggtatat atacatatat atatataaca tatatggaag aggaaaaggc 14640
tggtacaacg gaggcctgcg accctggggg cacaggaggc aggcatggcc ctgggcgggg 14700
cgtggggggg cgtggaggga ggccccaggg ggtctcaccc atgcaagcag aggaccaggg 14760
ccttttctgg caccgcagtt ttgttttaaa actggacctg tatatttgta aagctattta 14820
tgggcccctg gcactcttgt tcccacaccc caacacttcc agcatttagc tggccacatg 14880
gcggagagtt ttaattttta acttattgac aaccgagaag gtttatcccg ccgatagagg 14940
gacggccaag aatgtacgtc cagcctgccc cggagctgga ggatcccctc caagcctaaa 15000
aggttgttaa tagttggagg tgattccagt gaagatattt tatttccttt gtcctttttc 15060
aggagaatta gatttctata ggatttttct ttaggagatt tattttttgg acttcaaagc 15120
aagctggtat tttcatacaa attcttctaa ttgctgtgtg tcccaggcag ggagacggtt 15180
tccagggagg ggccggccct gtgtgcaggt tccgatgtta ttagatgtta caagtttata 15240
tatatctata tatataattt attgagtttt tacaagatgt atttgttgta gacttaacac 15300
ttcttacgca atgcttctag agttttatag cctggactgc tacctttcaa agcttggagg 15360
gaagccgtga attcagttgg ttcgttctgt actgttactg ggccctgagt ctgggcagct 15420
gtcccttgct tgcctgcagg gccatggctc agggtggtct cttcttgggg cccagtgcat 15480
ggtggccaga ggtgtcaccc aaaccggcag gtgcgatttt gttaacccag cgacgaactt 15540
tccgaaaaat aaagacacct ggttgctaac ctgg 15574
<210> 122
<211> 2911
<212> DNA
<213> Homo sapiens
<400> 122
gacaggaggt gggccgctcg cggccacgcc gccgtcgcgg gtacattcct cgctcccggc 60
cgaggagcgc tcgggctgtc tgcggaccct gccgcgtgca ggggtcgcgg ccggctggag 120
ctgggagtga ggcggcggag gagccaggtg aggaggagcc aggaaggcag ttggtgggaa 180
gtccagcttg ggtccctgag agctgtgaga aggagatgcg gctgctgctg gccctgttgg 240
gggtcctgct gagtgtgcct gggcctccag tcttgtccct ggaggcctct gaggaagtgg 300
agcttgagcc ctgcctggct cccagcctgg agcagcaaga gcaggagctg acagtagccc 360
ttgggcagcc tgtgcgtctg tgctgtgggc gggctgagcg tggtggccac tggtacaagg 420
agggcagtcg cctggcacct gctggccgtg tacggggctg gaggggccgc ctagagattg 480
ccagcttcct acctgaggat gctggccgct acctctgcct ggcacgaggc tccatgatcg 540
tcctgcagaa tctcaccttg attacaggtg actccttgac ctccagcaac gatgatgagg 600
accccaagtc ccatagggac ccctcgaata ggcacagtta cccccagcaa gcaccctact 660
ggacacaccc ccagcgcatg gagaagaaac tgcatgcagt acctgcgggg aacaccgtca 720
agttccgctg tccagctgca ggcaacccca cgcccaccat ccgctggctt aaggatggac 780
aggcctttca tggggagaac cgcattggag gcattcggct gcgccatcag cactggagtc 840
tcgtgatgga gagcgtggtg ccctcggacc gcggcacata cacctgcctg gtagagaacg 900
ctgtgggcag catccgctat aactacctgc tagatgtgct ggagcggtcc ccgcaccggc 960
ccatcctgca ggccgggctc ccggccaaca ccacagccgt ggtgggcagc gacgtggagc 1020
tgctgtgcaa ggtgtacagc gatgcccagc cccacatcca gtggctgaag cacatcgtca 1080
tcaacggcag cagcttcgga gccgacggtt tcccctatgt gcaagtccta aagactgcag 1140
acatcaatag ctcagaggtg gaggtcctgt acctgcggaa cgtgtcagcc gaggacgcag 1200
gcgagtacac ctgcctcgca ggcaattcca tcggcctctc ctaccagtct gcctggctca 1260
cggtgctgcc agaggaggac cccacatgga ccgcagcagc gcccgaggcc agttctccct 1320
ggagtcaggc tcttccggca agtcaagctc atccctggta cgaggcgtgc gtctctcctc 1380
cagcggcccc gccttgctcg ccggcctcgc tggtgcttgg gaagccccta ggcgagggct 1440
gctttggcca ggtagtacgt gcagaggcct ttggcatgga ccctgcccgg cctgaccaag 1500
ccagcactgt ggccgtcaag atgctcaaag acaacgcctc tgacaaggac ctggccgacc 1560
tggtctcgga gatggaggtg atgaagctga tcggccgaca caagaacatc atcaacctgc 1620
ttggtgtctg cacccaggaa gggcccctgt acgtgatcgt ggagtgcgcc gccaagggaa 1680
acctgcggga gttcctgcgg gcccggcgcc ccccaggccc cgacctcagc cccgacggtc 1740
ctcggagcag tgaggggccg ctctccttcc cagtcctggt ctcctgcgcc taccaggtgg 1800
cccgaggcat gcagtatctg gagtcccgga agtgtatcca ccgggacctg gctgcccgca 1860
atgtgctggt gactgaggac aatgtgatga agattgctga ctttgggctg gcccgcggcg 1920
tccaccacat tgactactat aagaaaacca gcaacggccg cctgcctgtg aagtggatgg 1980
cgcccgaggc cttgtttgac cgggtgtaca cacaccagag tgacgtgtgg tcttttggga 2040
tcctgctatg ggagatcttc accctcgggg gctccccgta tcctggcatc ccggtggagg 2100
agctgttctc gctgctgcgg gagggacatc ggatggaccg acccccacac tgccccccag 2160
agctgtacgg gctgatgcgt gagtgctggc acgcagcgcc ctcccagagg cctaccttca 2220
agcagctggt ggaggcgctg gacaaggtcc tgctggccgt ctctgaggag tacctcgacc 2280
tccgcctgac cttcggaccc tattccccct ctggtgggga cgccagcagc acctgctcct 2340
ccagcgattc tgtcttcagc cacgaccccc tgccattggg atccagctcc ttccccttcg 2400
ggtctggggt gcagacatga gcaaggctca aggctgtgca ggcacatagg ctggtggcct 2460
tgggccttgg ggctcagcca cagcctgaca cagtgctcga ccttgatagc atggggcccc 2520
tggcccagag ttgctgtgcc gtgtccaagg gccgtgccct tgcccttgga gctgccgtgc 2580
ctgtgtcctg atggcccaaa tgtcagggtt ctgctcggct tcttggacct tggcgcttag 2640
tccccatccc gggtttggct gagcctggct ggagagctgc tatgctaaac ctcctgcctc 2700
ccaataccag caggaggttc tgggcctctg aacccccttt ccccacacct ccccctgctg 2760
ctgctgcccc agcgtcttga cgggagcatt ggcccctgag cccagagaag ctggaagcct 2820
gccgaaaaca ggagcaaatg gcgttttata aattattttt ttgaaataaa gctctgtgtg 2880
cctgggaaaa aaaaaaaaaa aaaaaaaaaa a 2911
<210> 123
<211> 3115
<212> DNA
<213> Homo sapiens
<400> 123
gacaggaggt gggccgctcg cggccacgcc gccgtcgcgg gtacattcct cgctcccggc 60
cgaggagcgc tcgggctgtc tgcggaccct gccgcgtgca ggggtcgcgg ccggctggag 120
ctgggagtga ggcggcggag gagccaggtg aggaggagcc aggaaggcag ttggtgggaa 180
gtccagcttg ggtccctgag agctgtgaga aggagatgcg gctgctgctg gccctgttgg 240
gggtcctgct gagtgtgcct gggcctccag tcttgtccct ggaggcctct gaggaagtgg 300
agcttgagcc ctgcctggct cccagcctgg agcagcaaga gcaggagctg acagtagccc 360
ttgggcagcc tgtgcgtctg tgctgtgggc gggctgagcg tggtggccac tggtacaagg 420
agggcagtcg cctggcacct gctggccgtg tacggggctg gaggggccgc ctagagattg 480
ccagcttcct acctgaggat gctggccgct acctctgcct ggcacgaggc tccatgatcg 540
tcctgcagaa tctcaccttg attacaggtg actccttgac ctccagcaac gatgatgagg 600
accccaagtc ccatagggac ccctcgaata ggcacagtta cccccagcaa gcaccctact 660
ggacacaccc ccagcgcatg gagaagaaac tgcatgcagt acctgcgggg aacaccgtca 720
agttccgctg tccagctgca ggcaacccca cgcccaccat ccgctggctt aaggatggac 780
aggcctttca tggggagaac cgcattggag gcattcggct gcgccatcag cactggagtc 840
tcgtgatgga gagcgtggtg ccctcggacc gcggcacata cacctgcctg gtagagaacg 900
ctgtgggcag catccgctat aactacctgc tagatgtgct ggagcggtcc ccgcaccggc 960
ccatcctgca ggccgggctc ccggccaaca ccacagccgt ggtgggcagc gacgtggagc 1020
tgctgtgcaa ggtgtacagc gatgcccagc cccacatcca gtggctgaag cacatcgtca 1080
tcaacggcag cagcttcgga gccgacggtt tcccctatgt gcaagtccta aagactgcag 1140
acatcaatag ctcagaggtg gaggtcctgt acctgcggaa cgtgtcagcc gaggacgcag 1200
gcgagtacac ctgcctcgca ggcaattcca tcggcctctc ctaccagtct gcctggctca 1260
cggtgctgcc agaggaggac cccacatgga ccgcagcagc gcccgaggcc aggtatacgg 1320
acatcatcct gtacgcgtcg ggctccctgg ccttggctgt gctcctgctg ctggccgggc 1380
tgtatcgagg gcaggcgctc cacggccggc acccccgccc gcccgccact gtgcagaagc 1440
tctcccgctt ccctctggcc cgacagttct ccctggagtc aggctcttcc ggcaagtcaa 1500
gctcatccct ggtacgaggc gtgcgtctct cctccagcgg ccccgccttg ctcgccggcc 1560
tcgtgagtct agatctacct ctcgacccac tatgggagtt cccccgggac aggctggtgc 1620
ttgggaagcc cctaggcgag ggctgctttg gccaggtagt acgtgcagag gcctttggca 1680
tggaccctgc ccggcctgac caagccagca ctgtggccgt caagatgctc aaagacaacg 1740
cctctgacaa ggacctggcc gacctggtct cggagatgga ggtgatgaag ctgatcggcc 1800
gacacaagaa catcatcaac ctgcttggtg tctgcaccca ggaagggccc ctgtacgtga 1860
tcgtggagtg cgccgccaag ggaaacctgc gggagttcct gcgggcccgg cgccccccag 1920
gccccgacct cagccccgac ggtcctcgga gcagtgaggg gccgctctcc ttcccagtcc 1980
tggtctcctg cgcctaccag gtggcccgag gcatgcagta tctggagtcc cggaagtgta 2040
tccaccggga cctggctgcc cgcaatgtgc tggtgactga ggacaatgtg atgaagattg 2100
ctgactttgg gctggcccgc ggcgtccacc acattgacta ctataagaaa accagcaacg 2160
gccgcctgcc tgtgaagtgg atggcgcccg aggccttgtt tgaccgggtg tacacacacc 2220
agagtgacgt gtggtctttt gggatcctgc tatgggagat cttcaccctc gggggctccc 2280
cgtatcctgg catcccggtg gaggagctgt tctcgctgct gcgggaggga catcggatgg 2340
accgaccccc acactgcccc ccagagctgt acgggctgat gcgtgagtgc tggcacgcag 2400
cgccctccca gaggcctacc ttcaagcagc tggtggaggc gctggacaag gtcctgctgg 2460
ccgtctctga ggagtacctc gacctccgcc tgaccttcgg accctattcc ccctctggtg 2520
gggacgccag cagcacctgc tcctccagcg attctgtctt cagccacgac cccctgccat 2580
tgggatccag ctccttcccc ttcgggtctg gggtgcagac atgagcaagg ctcaaggctg 2640
tgcaggcaca taggctggtg gccttgggcc ttggggctca gccacagcct gacacagtgc 2700
tcgaccttga tagcatgggg cccctggccc agagttgctg tgccgtgtcc aagggccgtg 2760
cccttgccct tggagctgcc gtgcctgtgt cctgatggcc caaatgtcag ggttctgctc 2820
ggcttcttgg accttggcgc ttagtcccca tcccgggttt ggctgagcct ggctggagag 2880
ctgctatgct aaacctcctg cctcccaata ccagcaggag gttctgggcc tctgaacccc 2940
ctttccccac acctccccct gctgctgctg ccccagcgtc ttgacgggag cattggcccc 3000
tgagcccaga gaagctggaa gcctgccgaa aacaggagca aatggcgttt tataaattat 3060
ttttttgaaa taaagctctg tgtgcctggg aaaaaaaaaa aaaaaaaaaa aaaaa 3115
<210> 124
<211> 2833
<212> DNA
<213> Homo sapiens
<400> 124
gaaggcagtt ggtgggaagt ccagcttggg tccctgagag ctgtgagaag gagatgcggc 60
tgctgctggc cctgttgggg gtcctgctga gtgtgcctgg gcctccagtc ttgtccctgg 120
aggcctctga ggaagtggag cttgagccct gcctggctcc cagcctggag cagcaagagc 180
aggagctgac agtagccctt gggcagcctg tgcgtctgtg ctgtgggcgg gctgagcgtg 240
gtggccactg gtacaaggag ggcagtcgcc tggcacctgc tggccgtgta cggggctgga 300
ggggccgcct agagattgcc agcttcctac ctgaggatgc tggccgctac ctctgcctgg 360
cacgaggctc catgatcgtc ctgcagaatc tcaccttgat tacaggtgac tccttgacct 420
ccagcaacga tgatgaggac cccaagtccc atagggaccc ctcgaatagg cacagttacc 480
cccagcaagc accctactgg acacaccccc agcgcatgga gaagaaactg catgcagtac 540
ctgcggggaa caccgtcaag ttccgctgtc cagctgcagg caaccccacg cccaccatcc 600
gctggcttaa ggatggacag gcctttcatg gggagaaccg cattggaggc attcggctgc 660
gccatcagca ctggagtctc gtgatggaga gcgtggtgcc ctcggaccgc ggcacataca 720
cctgcctggt agagaacgct gtgggcagca tccgctataa ctacctgcta gatgtgctgg 780
agcggtcccc gcaccggccc atcctgcagg ccgggctccc ggccaacacc acagccgtgg 840
tgggcagcga cgtggagctg ctgtgcaagg tgtacagcga tgcccagccc cacatccagt 900
ggctgaagca catcgtcatc aacggcagca gcttcggagc cgacggtttc ccctatgtgc 960
aagtcctaaa gactgcagac atcaatagct cagaggtgga ggtcctgtac ctgcggaacg 1020
tgtcagccga ggacgcaggc gagtacacct gcctcgcagg caattccatc ggcctctcct 1080
accagtctgc ctggctcacg gtgctgccag gtactgggcg catcccccac ctcacatgtg 1140
acagcctgac tccagcaggc agaaccaagt ctcccacttt gcagttctcc ctggagtcag 1200
gctcttccgg caagtcaagc tcatccctgg tacgaggcgt gcgtctctcc tccagcggcc 1260
ccgccttgct cgccggcctc gtgagtctag atctacctct cgacccacta tgggagttcc 1320
cccgggacag gctggtgctt gggaagcccc taggcgaggg ctgctttggc caggtagtac 1380
gtgcagaggc ctttggcatg gaccctgccc ggcctgacca agccagcact gtggccgtca 1440
agatgctcaa agacaacgcc tctgacaagg acctggccga cctggtctcg gagatggagg 1500
tgatgaagct gatcggccga cacaagaaca tcatcaacct gcttggtgtc tgcacccagg 1560
aagggcccct gtacgtgatc gtggagtgcg ccgccaaggg aaacctgcgg gagttcctgc 1620
gggcccggcg ccccccaggc cccgacctca gccccgacgg tcctcggagc agtgaggggc 1680
cgctctcctt cccagtcctg gtctcctgcg cctaccaggt ggcccgaggc atgcagtatc 1740
tggagtcccg gaagtgtatc caccgggacc tggctgcccg caatgtgctg gtgactgagg 1800
acaatgtgat gaagattgct gactttgggc tggcccgcgg cgtccaccac attgactact 1860
ataagaaaac cagcaacggc cgcctgcctg tgaagtggat ggcgcccgag gccttgtttg 1920
accgggtgta cacacaccag agtgacgtgt ggtcttttgg gatcctgcta tgggagatct 1980
tcaccctcgg gggctccccg tatcctggca tcccggtgga ggagctgttc tcgctgctgc 2040
gggagggaca tcggatggac cgacccccac actgcccccc agagctgtac gggctgatgc 2100
gtgagtgctg gcacgcagcg ccctcccaga ggcctacctt caagcagctg gtggaggcgc 2160
tggacaaggt cctgctggcc gtctctgagg agtacctcga cctccgcctg accttcggac 2220
cctattcccc ctctggtggg gacgccagca gcacctgctc ctccagcgat tctgtcttca 2280
gccacgaccc cctgccattg ggatccagct ccttcccctt cgggtctggg gtgcagacat 2340
gagcaaggct caaggctgtg caggcacata ggctggtggc cttgggcctt ggggctcagc 2400
cacagcctga cacagtgctc gaccttgata gcatggggcc cctggcccag agttgctgtg 2460
ccgtgtccaa gggccgtgcc cttgcccttg gagctgccgt gcctgtgtcc tgatggccca 2520
aatgtcaggg ttctgctcgg cttcttggac cttggcgctt agtccccatc ccgggtttgg 2580
ctgagcctgg ctggagagct gctatgctaa acctcctgcc tcccaatacc agcaggaggt 2640
tctgggcctc tgaaccccct ttccccacac ctccccctgc tgctgctgcc ccagcgtctt 2700
gacgggagca ttggcccctg agcccagaga agctggaagc ctgccgaaaa caggagcaaa 2760
tggcgtttta taaattattt ttttgaaata aagctctgtg tgcctgggaa aaaaaaaaaa 2820
aaaaaaaaaa aaa 2833
<210> 125
<211> 3093
<212> DNA
<213> Homo sapiens
<400> 125
cattcctcgc tcccggccga ggagcgctcg ggctgtctgc ggaccctgcc gcgtgcaggg 60
gtcgcggccg gctggagctg ggagtgaggc ggcggaggag ccaggtgagg aggagccagg 120
tgagcaggac cctgtgctgg gcgcggagtc acgcaggctc gaggaaggca gttggtggga 180
agtccagctt gggtccctga gagctgtgag aaggagatgc ggctgctgct ggccctgttg 240
ggggtcctgc tgagtgtgcc tgggcctcca gtcttgtccc tggaggcctc tgaggaagtg 300
gagcttgagc cctgcctggc tcccagcctg gagcagcaag agcaggagct gacagtagcc 360
cttgggcagc ctgtgcgtct gtgctgtggg cgggctgagc gtggtggcca ctggtacaag 420
gagggcagtc gcctggcacc tgctggccgt gtacggggct ggaggggccg cctagagatt 480
gccagcttcc tacctgagga tgctggccgc tacctctgcc tggcacgagg ctccatgatc 540
gtcctgcaga atctcacctt gattacaggt gactccttga cctccagcaa cgatgatgag 600
gaccccaagt cccataggga cccctcgaat aggcacagtt acccccagca agcaccctac 660
tggacacacc cccagcgcat ggagaagaaa ctgcatgcag tacctgcggg gaacaccgtc 720
aagttccgct gtccagctgc aggcaacccc acgcccacca tccgctggct taaggatgga 780
caggcctttc atggggagaa ccgcattgga ggcattcggc tgcgccatca gcactggagt 840
ctcgtgatgg agagcgtggt gccctcggac cgcggcacat acacctgcct ggtagagaac 900
gctgtgggca gcatccgcta taactacctg ctagatgtgc tggagcggtc cccgcaccgg 960
cccatcctgc aggccgggct cccggccaac accacagccg tggtgggcag cgacgtggag 1020
ctgctgtgca aggtgtacag cgatgcccag ccccacatcc agtggctgaa gcacatcgtc 1080
atcaacggca gcagcttcgg agccgacggt ttcccctatg tgcaagtcct aaagactgca 1140
gacatcaata gctcagaggt ggaggtcctg tacctgcgga acgtgtcagc cgaggacgca 1200
ggcgagtaca cctgcctcgc aggcaattcc atcggcctct cctaccagtc tgcctggctc 1260
acggtgctgc cagaggagga ccccacatgg accgcagcag cgcccgaggc caggtatacg 1320
gacatcatcc tgtacgcgtc gggctccctg gccttggctg tgctcctgct gctggccggg 1380
ctgtatcgag ggcaggcgct ccacggccgg cacccccgcc cgcccgccac tgtgcagaag 1440
ctctcccgct tccctctggc ccgacagttc tccctggagt caggctcttc cggcaagtca 1500
agctcatccc tggtacgagg cgtgcgtctc tcctccagcg gccccgcctt gctcgccggc 1560
ctcgtgagtc tagatctacc tctcgaccca ctatgggagt tcccccggga caggctggtg 1620
cttgggaagc ccctaggcga gggctgcttt ggccaggtag tacgtgcaga ggcctttggc 1680
atggaccctg cccggcctga ccaagccagc actgtggccg tcaagatgct caaagacaac 1740
gcctctgaca aggacctggc cgacctggtc tcggagatgg aggtgatgaa gctgatcggc 1800
cgacacaaga acatcatcaa cctgcttggt gtctgcaccc aggaagggcc cctgtacgtg 1860
atcgtggagt gcgccgccaa gggaaacctg cgggagttcc tgcgggcccg gcgcccccca 1920
ggccccgacc tcagccccga cggtcctcgg agcagtgagg ggccgctctc cttcccagtc 1980
ctggtctcct gcgcctacca ggtggcccga ggcatgcagt atctggagtc ccggaagtgt 2040
atccaccggg acctggctgc ccgcaatgtg ctggtgactg aggacaatgt gatgaagatt 2100
gctgactttg ggctggcccg cggcgtccac cacattgact actataagaa aaccagcaac 2160
ggccgcctgc ctgtgaagtg gatggcgccc gaggccttgt ttgaccgggt gtacacacac 2220
cagagtgacg tgtggtcttt tgggatcctg ctatgggaga tcttcaccct cgggggctcc 2280
ccgtatcctg gcatcccggt ggaggagctg ttctcgctgc tgcgggaggg acatcggatg 2340
gaccgacccc cacactgccc cccagagctg tacgggctga tgcgtgagtg ctggcacgca 2400
gcgccctccc agaggcctac cttcaagcag ctggtggagg cgctggacaa ggtcctgctg 2460
gccgtctctg aggagtacct cgacctccgc ctgaccttcg gaccctattc cccctctggt 2520
ggggacgcca gcagcacctg ctcctccagc gattctgtct tcagccacga ccccctgcca 2580
ttgggatcca gctccttccc cttcgggtct ggggtgcaga catgagcaag gctcaaggct 2640
gtgcaggcac ataggctggt ggccttgggc cttggggctc agccacagcc tgacacagtg 2700
ctcgaccttg atagcatggg gcccctggcc cagagttgct gtgccgtgtc caagggccgt 2760
gcccttgccc ttggagctgc cgtgcctgtg tcctgatggc ccaaatgtca gggttctgct 2820
cggcttcttg gaccttggcg cttagtcccc atcccgggtt tggctgagcc tggctggaga 2880
gctgctatgc taaacctcct gcctcccaat accagcagga ggttctgggc ctctgaaccc 2940
cctttcccca cacctccccc tgctgctgct gccccagcgt cttgacggga gcattggccc 3000
ctgagcccag agaagctgga agcctgccga aaacaggagc aaatggcgtt ttataaatta 3060
tttttttgaa ataaagctct gtgtgcctgg gtc 3093
<210> 126
<211> 3075
<212> DNA
<213> Homo sapiens
<400> 126
gacaggaggt gggccgctcg cggccacgcc gccgtcgcgg gtacattcct cgctcccggc 60
cgaggagcgc tcgggctgtc tgcggaccct gccgcgtgca ggggtcgcgg ccggctggag 120
ctgggagtga ggcggcggag gagccaggaa ggcagttggt gggaagtcca gcttgggtcc 180
ctgagagctg tgagaaggag atgcggctgc tgctggccct gttgggggtc ctgctgagtg 240
tgcctgggcc tccagtcttg tccctggagg cctctgagga agtggagctt gagccctgcc 300
tggctcccag cctggagcag caagagcagg agctgacagt agcccttggg cagcctgtgc 360
gtctgtgctg tgggcgggct gagcgtggtg gccactggta caaggagggc agtcgcctgg 420
cacctgctgg ccgtgtacgg ggctggaggg gccgcctaga gattgccagc ttcctacctg 480
aggatgctgg ccgctacctc tgcctggcac gaggctccat gatcgtcctg cagaatctca 540
ccttgattac aggtgactcc ttgacctcca gcaacgatga tgaggacccc aagtcccata 600
gggacccctc gaataggcac agttaccccc agcaagcacc ctactggaca cacccccagc 660
gcatggagaa gaaactgcat gcagtacctg cggggaacac cgtcaagttc cgctgtccag 720
ctgcaggcaa ccccacgccc accatccgct ggcttaagga tggacaggcc tttcatgggg 780
agaaccgcat tggaggcatt cggctgcgcc atcagcactg gagtctcgtg atggagagcg 840
tggtgccctc ggaccgcggc acatacacct gcctggtaga gaacgctgtg ggcagcatcc 900
gctataacta cctgctagat gtgctggagc ggtccccgca ccggcccatc ctgcaggccg 960
ggctcccggc caacaccaca gccgtggtgg gcagcgacgt ggagctgctg tgcaaggtgt 1020
acagcgatgc ccagccccac atccagtggc tgaagcacat cgtcatcaac ggcagcagct 1080
tcggagccga cggtttcccc tatgtgcaag tcctaaagac tgcagacatc aatagctcag 1140
aggtggaggt cctgtacctg cggaacgtgt cagccgagga cgcaggcgag tacacctgcc 1200
tcgcaggcaa ttccatcggc ctctcctacc agtctgcctg gctcacggtg ctgccagagg 1260
aggaccccac atggaccgca gcagcgcccg aggccaggta tacggacatc atcctgtacg 1320
cgtcgggctc cctggccttg gctgtgctcc tgctgctggc cgggctgtat cgagggcagg 1380
cgctccacgg ccggcacccc cgcccgcccg ccactgtgca gaagctctcc cgcttccctc 1440
tggcccgaca gttctccctg gagtcaggct cttccggcaa gtcaagctca tccctggtac 1500
gaggcgtgcg tctctcctcc agcggccccg ccttgctcgc cggcctcgtg agtctagatc 1560
tacctctcga cccactatgg gagttccccc gggacaggct ggtgcttggg aagcccctag 1620
gcgagggctg ctttggccag gtagtacgtg cagaggcctt tggcatggac cctgcccggc 1680
ctgaccaagc cagcactgtg gccgtcaaga tgctcaaaga caacgcctct gacaaggacc 1740
tggccgacct ggtctcggag atggaggtga tgaagctgat cggccgacac aagaacatca 1800
tcaacctgct tggtgtctgc acccaggaag ggcccctgta cgtgatcgtg gagtgcgccg 1860
ccaagggaaa cctgcgggag ttcctgcggg cccggcgccc cccaggcccc gacctcagcc 1920
ccgacggtcc tcggagcagt gaggggccgc tctccttccc agtcctggtc tcctgcgcct 1980
accaggtggc ccgaggcatg cagtatctgg agtcccggaa gtgtatccac cgggacctgg 2040
ctgcccgcaa tgtgctggtg actgaggaca atgtgatgaa gattgctgac tttgggctgg 2100
cccgcggcgt ccaccacatt gactactata agaaaaccag caacggccgc ctgcctgtga 2160
agtggatggc gcccgaggcc ttgtttgacc gggtgtacac acaccagagt gacgtgtggt 2220
cttttgggat cctgctatgg gagatcttca ccctcggggg ctccccgtat cctggcatcc 2280
cggtggagga gctgttctcg ctgctgcggg agggacatcg gatggaccga cccccacact 2340
gccccccaga gctgtacggg ctgatgcgtg agtgctggca cgcagcgccc tcccagaggc 2400
ctaccttcaa gcagctggtg gaggcgctgg acaaggtcct gctggccgtc tctgaggagt 2460
acctcgacct ccgcctgacc ttcggaccct attccccctc tggtggggac gccagcagca 2520
cctgctcctc cagcgattct gtcttcagcc acgaccccct gccattggga tccagctcct 2580
tccccttcgg gtctggggtg cagacatgag caaggctcaa ggctgtgcag gcacataggc 2640
tggtggcctt gggccttggg gctcagccac agcctgacac agtgctcgac cttgatagca 2700
tggggcccct ggcccagagt tgctgtgccg tgtccaaggg ccgtgccctt gcccttggag 2760
ctgccgtgcc tgtgtcctga tggcccaaat gtcagggttc tgctcggctt cttggacctt 2820
ggcgcttagt ccccatcccg ggtttggctg agcctggctg gagagctgct atgctaaacc 2880
tcctgcctcc caataccagc aggaggttct gggcctctga accccctttc cccacacctc 2940
cccctgctgc tgctgcccca gcgtcttgac gggagcattg gcccctgagc ccagagaagc 3000
tggaagcctg ccgaaaacag gagcaaatgg cgttttataa attatttttt tgaaataaag 3060
ctctgtgtgc ctggg 3075
<210> 127
<211> 11271
<212> DNA
<213> Homo sapiens
<400> 127
gacaggaggt gggccgctcg cggccacgcc gccgtcgcgg gtacattcct cgctcccggc 60
cgaggagcgc tcgggctgtc tgcggaccct gccgcgtgca ggggtcgcgg ccggctggag 120
ctgggagtga ggcggcggag gagccaggtg aggaggagcc aggtgagcag gaccctgtgc 180
tgggcgcgga gtcacgcagg ctcgaggtga gccggaaccc ttgtgggccc gggctgcgct 240
cccagccgcc agggggcgag aggcggcggg gctacgggga ctgcccctcc cggcgcaggg 300
gacctgggcg tccgccgggc ggcagggggt ggagggggcg gtaaatcagt aacccgcagt 360
gcacacaggg ccttttgtcc cgctccgtcc aaagagcacc ccggccgcgg agctggttac 420
tcattgccca ccgaggcggg ggcaggctgg ccctgtgcag ctaccctcgg gacccattga 480
ttcgcacctc cccccaggct ggcccggcaa gggtggggga ggacaagcgc gcttgtccct 540
gcggctgtct tcgcgccggc ggcagagatg agggacctga ggccccgaaa agttcagtca 600
cttagtgccc gggggcctcc agcgcgagtg cgggaggctg aaggagaacc caggactgtc 660
tgatgcctaa ggcaggccct ccattcccac gtggggggtg gtcggtcagc ggtcagcagc 720
catgggtgac tcgactaagg actctgatat cagggcagcc tggggtagga ataaactccc 780
cgggcctccc cacccactcc cagcccaagc tgtgtaccca aagagctgcc ctccctgcca 840
agccgagctt ggtagggagt tttaccaagg aggatccgac tggattcgag agttgaggtg 900
ggccagagac agcagtatct gagtcaggta gagaagagca atgaggggca cagagggatg 960
ggcaagagag cacatgtgcc cagttttgaa agccaatggc ttcagcgctc ctgaaggggc 1020
agacggtgtg accaaagaga taggcagcgg cagagaggga gccctaggat gttgagctgg 1080
atcctgctgg gcacaggtag ccattaaggg cttgcaagct ggggggcatg acatggcaga 1140
cttgcaggtt tttttgtttg tttttttatt ttattttatt tttttatttt gttttttttg 1200
agacggagtc tcactctgtc gcccaggctg gagtgcagtg gcgcgatctc ggctcactgc 1260
aagctccgcc tcccgggttc gcgccattct cctgcctcag cctcccgagt agctgggact 1320
acaggcgccc gccaccgcgc ccggctaatt ttttgtattt ttagtagaga cggggtttca 1380
ccgtgttagc caggatgttc tcgatctcct gacctcgtga tccgcccacc tcggcctccc 1440
aaagtgctgg gattacaggt gtgaaccatc gcgcccagcc gacttgtagt tttttaaaac 1500
tctgctggaa gatgaaggtt gaagagccga gggagaggat gtttccagag gcccatgcaa 1560
gagatggcca tgacctgcct tgagaagggg caggggaagc cagatggact ggaagtggag 1620
tggcagtgac caaggaggag gaggtgtgat aggcttccca cgcagggtag atccagagac 1680
accagtgcca cccataggcc cctaggactg cagtggtcac cgattccttt gtcccagctg 1740
agactcagtt ctgagtgttc tattttgggg aacagaggcg tccttggtag catttggaag 1800
aggatagcca gctggggtgt gtgtacatca cagcctgaca gtaacagcat ccgaaccaga 1860
ggtgactggc taagggcaga cccagggcaa caggttaacc gttctagggc cgggcacagg 1920
gaggagaaca ttccaacact ctgcgtgccg acgcacgttc tctcttttat cctcaaaaca 1980
gtcctatgag gatagtaagc cagagagaga cagagacaag gaattacaag ttggtgagag 2040
tcaggatttg aacttggctc tggcagatgg aaaattaggg tctgtattct ttacaaaacc 2100
gtgtgtgcct cagatggagt tggtgcataa caagcagagg tatccagggt cgcggtcctg 2160
cttgccacgg aaggggccgc cttgtcagtt gtgaccaccc agccctggaa atgtcagtaa 2220
tgctgtaagg agtggggatc ggatcagatg ccatccagat gctgaagttt gaccttgtgt 2280
catttttcac tttctttttt ggctcttctg caatcaattc atttatttag caaaaaagaa 2340
attatgtgtg ccgagagcat gcagaagata tgtctccgtt ctctgcttcc ctccaaaaaa 2400
gaatcccaaa actgctttct gtgaacgtgt gccagggtcc cagcaggact cagggagagc 2460
aggaagccca gcccagaccc cttgcacaac ctaccgtggg gaggccttag gctctggcta 2520
ctacagagct ggttccagtc tgcactgcca cagcctggcc agggacttgg acacatctgc 2580
tggccacttc ctgtctcagt ttccttatct gcaaaataag ggaaaagccc ccacaaaggt 2640
gcacgtgtag caggagctct tttccctccc tattttagga aggcagttgg tgggaagtcc 2700
agcttgggtc cctgagagct gtgagaagga gatgcggctg ctgctggccc tgttgggggt 2760
cctgctgagt gtgcctgggc ctccagtctt gtccctggag gcctctgagg aagtggagct 2820
tggtatggct tctgaggtgg gagagggtgg caggggtggg aagagtgggc accaggaggg 2880
ggctgctggg ctgagcaaag ctggaaagga tccttgccca ggccctgaga aggtggcggc 2940
agggcagggc tcaaccactg agactcagtc agtgcctggc ttccagcaag cattcatcta 3000
tcactgtgtc tgcgagagag gactggcctt gcagggcgca gggccctaag ctgggctgca 3060
gagctggtgg tgagctcctt acctgggtgt gtgtgcgtgt gtgtgtgtgt tctgtgcact 3120
gggtgtgtga cctaggaggt ccaggcagca tgtgtggtat aagcattatg agggtgatat 3180
gccccggtgc agcatgaccc tgtatgtggc accaacagca tgtgccttgt gtgtgtgtgt 3240
gtccgtatgt gtgtgtgtgt atgcgtgtgt gtgtgtgtgt gtgtcttggc cactgtcgtg 3300
tgcactaaat gctgtgtgtg tgacatgccc caagagtgtg gcatttgccc tgggtgtggc 3360
atccgcagca tgtggctgtg tgggtgtcaa ggagtggtgg ctccttcagc atgcgttgca 3420
aagtgcttgt gccctgcatg tgcggtgtgt tctttgtaca caggaggctg cctcagatgg 3480
ggctgcgggg tctgctgacc tctgccctct gcccacagag ccctgcctgg ctcccagcct 3540
ggagcagcaa gagcaggagc tgacagtagc ccttgggcag cctgtgcgtc tgtgctgtgg 3600
gcgggctgag cgtggtggcc actggtacaa ggagggcagt cgcctggcac ctgctggccg 3660
tgtacggggc tggaggggcc gcctagagat tgccagcttc ctacctgagg atgctggccg 3720
ctacctctgc ctggcacgag gctccatgat cgtcctgcag aatctcacct tgattacagg 3780
tggtaagaga ctctagcagg gagtgaaggg atgcctgggg agacagacct gcccctcttg 3840
gaccttagat gcttccctct gtccctgatg tagactcctt gacctccagc aacgatgatg 3900
aggaccccaa gtcccatagg gacccctcga ataggcacag ttacccccag caaggtcagt 3960
aggtctccaa ggacttgtgt ccccgctgct gctcatctga tcactgagaa gaggaggcct 4020
gtgtgggaac acacggtcat tctaggggcc ttcccctgcc ctccagcacc ctactggaca 4080
cacccccagc gcatggagaa gaaactgcat gcagtacctg cggggaacac cgtcaagttc 4140
cgctgtccag ctgcaggcaa ccccacgccc accatccgct ggcttaagga tggacaggcc 4200
tttcatgggg agaaccgcat tggaggcatt cgggtgagtc tctgggttcc aagaccgtct 4260
gctcccccat tttcattcct tcatcagtcc cctcatacct acaagcatac ctataaatca 4320
atcgaatgag tgaagcgatt gcggggcccc ggaaggagcc ctggactgtg gacctgggca 4380
gctctggttc cccttctgct actctctggc aagtgactta acctctcagc ctcagcaact 4440
ccatttgtaa agggagaaga atcactgact ggttggtctg cataagcctt agcatctcat 4500
cgtcttgatg agaccctgca gggtcggctc catgctgtca tgaggcaact gagtctcaga 4560
gaaggcaagg gttggctcaa agtagcacag ctagggagag ggagagctaa aattccaaag 4620
gctcaaaccc aaggctcaag cgccctgggg agcctactcc tttgtgccat agtccttggc 4680
ctgggcctga tgttctcagg gcctagagag cttgacaaga gccctgtggg caggatgagg 4740
atctagcctc ctggtcctct ggcccccttg gtggacatgg tccggtggtc ccggacactc 4800
tctctgcctg cagctgcgcc atcagcactg gagtctcgtg atggagagcg tggtgccctc 4860
ggaccgcggc acatacacct gcctggtaga gaacgctgtg ggcagcatcc gctataacta 4920
cctgctagat gtgctgggtg agcgcggggc tgggaacagg ggaggcctga cccattttgg 4980
gctcagttgt gccctcttgg tggggtctag tctggcaggc aggatggact cagatgagtc 5040
aggcagcttg gtgagcaggt gggtcagggg aaagcacagg ggttagtgtg gggctggagg 5100
agcagaggtc tgccaagagg aaaaacaaga aggacatcca ggcagagggc gcagcccgag 5160
cggagggcct gagtataaca aacgccctgc acttgcaggc cagcatattc gtagggcgtg 5220
gcgtttatat ggggagccag gtggtggagg gttttgaatg ctaggctgag atgttgtcct 5280
tgacccgaag caatagggag ccagggaagg tttaagcagg gtaagcagga gacagacaag 5340
aagctgcaga aaggtccctc ccttgaactt gaggaaggct ggagggaggc aaacagggtg 5400
cttctatggg tgccggtggt cagggttgac tgtctcgccc ggtccccaga gcggtccccg 5460
caccggccca tcctgcaggc cgggctcccg gccaacacca cagccgtggt gggcagcgac 5520
gtggagctgc tgtgcaaggt gtacagcgat gcccagcccc acatccagtg gctgaagcac 5580
atcgtcatca acggcagcag cttcggagcc gacggtttcc cctatgtgca agtcctaaag 5640
gtaaaaggtg caccctgctg cagcctgggc cccattcttc tcccaccttg ggttgggggg 5700
ctccccagct tccctgttgg ccacagtgtg gccccaggcc ctgctgtgac cccagagcat 5760
gtcccccacc ccagactgca gacatcaata gctcagaggt ggaggtcctg tacctgcgga 5820
acgtgtcagc cgaggacgca ggcgagtaca cctgcctcgc aggcaattcc atcggcctct 5880
cctaccagtc tgcctggctc acggtgctgc caggtgagca cctgaagggc caggagatgc 5940
tgcgagatgc ccctctgggc cagcagtggg ggctgtggcc tgttgggtgg tcagtctctg 6000
ttggcctgtg gggtctggcc tggggggcag tgtgtggatt tgtgggtttg agctgtatga 6060
cagcccctct gtgcctctcc acacgtggcc gtccatgtga ccgtctgctg aggtgtgggt 6120
gcctgggact gggcataact acagcttcct ccgtgtgtgt ccccacatat gttgggagct 6180
gggagggact gagttagggt gcacggggcg gccagtctca ccactgacca gtttgtctgt 6240
ctgtgtgtgt ccatgtgcga gggcagagga ggaccccaca tggaccgcag cagcgcccga 6300
ggccaggtat acggacatca tcctgtacgc gtcgggctcc ctggccttgg ctgtgctcct 6360
gctgctggcc gggctgtatc gagggcaggc gctccacggc cggcaccccc gcccgcccgc 6420
cactgtgcag aagctctccc gcttccctct ggcccgacag gtactgggcg catcccccac 6480
ctcacatgtg acagcctgac tccagcaggc agaaccaagt ctcccacttt gcagttctcc 6540
ctggagtcag gctcttccgg caagtcaagc tcatccctgg tacgaggcgt gcgtctctcc 6600
tccagcggcc ccgccttgct cgccggcctc gtgagtctag atctacctct cgacccacta 6660
tgggagttcc cccgggacag gtgcgctgag ctgtgtgggg gcagggacgc gggcgccggg 6720
ttgcagcccg ccctccgcag gagtgactcg gaggtctgag gctggacttt ctccatctcc 6780
aggctggtgc ttgggaagcc cctaggcgag ggctgctttg gccaggtagt acgtgcagag 6840
gcctttggca tggaccctgc ccggcctgac caagccagca ctgtggccgt caagatgctc 6900
aaaggtgagt gtggcccggt gtggtggctc acacctgtaa cgccagcact ttaggaggct 6960
gagggtggga ggatcgcttg aatccaggaa ttcgaggcca gcctgggcaa catggcaaga 7020
cttcatctct acaaaaaaaa aataagaaaa ttagttgggt gtggtggtgt gtgcctttag 7080
tctcagttac tagggaggct gaggcaggag gatcccttga atccaggagt tggaggttgc 7140
agggagccat gatcacgcca ctgtattcca gcctgggcaa cacagtgaga ccctatctga 7200
aaaaataaat aaataaataa aaataaaagg tgaacgtggc agcctggagg aggtgctatg 7260
gcattgggac taatagaagg ggctcacggt gccaccaggt gagccctgga gctgggagag 7320
gctgtgggat cccaccctta aacctgcaat tcacctctgc tcctgaccct ggcaagtgac 7380
ttctgagcct cagttttccc ttgtgtcata tggggtagat aacagtccct actcccagcc 7440
caaggattgt ggaaagtgcc tggctcatag tcagggctca ataaatcttc accactgggg 7500
tgatgatgat gagaagaatt tggtgtgaca ggcttgatat cctgtgtcag cattagtctg 7560
tgtcagcttt gacttcacat ctccttgtca gcctcacagg ccctctacct ccttccttat 7620
ggttcccccc agacacaccc tcagcctccc ttggaccctc cctaggtctg ccccccacgt 7680
ccactgctgt aggaggacag cccttctgct tgcacccagg cccagccccg gggtgctctt 7740
gctgggcact cctgcacccc acccatcagg gcctctcctt gcagttcccc agccccctct 7800
gcaagaatgg cctccactgc tcttctgctc ctcccctcct ctctacacag ctggggccac 7860
ctggtgctcc ctgggaggca gggattgaga aatgcacatt gtgtcattgg cccagggcca 7920
caggtcagcc ccaggggctc agccagagaa gccaaagcag ccttcttccc aagctccccg 7980
gctgcacccg gcctgccgcc agctccctga attcccaggc cagttggaag ccaggccctg 8040
gtcaaacaga ccccagggcg ccagcctgct ttccgcaccc agaagctctg accccatgcg 8100
gggactaccg ctgacccctc cagcggcagc ttccttcctt ccttcctgct ccgagctctt 8160
cccctctctc ctgtgtcctg ggcctgcccg ctggaaggcc tgcctcttag atccttgata 8220
cagttgcatc cttgcaactg ctgtgacagg cagggtgtga cccactgctc tgtttcccac 8280
aagacgaacc tgaggttcag agacgctagg agactttttc aaggccacac agcctagcaa 8340
ggattcagcc ctagacctac gtagccctgg tccagtgctg cttgtcctgc acctgcctct 8400
gcatgctccc tcgtgcagtt ggagggcagc ctcttcaccc cgtctgctgc ccttacagac 8460
aacgcctctg acaaggacct ggccgacctg gtctcggaga tggaggtgat gaagctgatc 8520
ggccgacaca agaacatcat caacctgctt ggtgtctgca cccaggaagg tggggccgag 8580
gcggggctgg ctgcacgggc cgttagggtg cagagccaaa gctttggcag cctctccacg 8640
ctccctccac tccctctgca gggcccctgt acgtgatcgt ggagtgcgcc gccaagggaa 8700
acctgcggga gttcctgcgg gcccggcgcc ccccaggccc cgacctcagc cccgacggtc 8760
ctcggagcag tgaggggccg ctctccttcc cagtcctggt ctcctgcgcc taccaggtgg 8820
cccgaggcat gcagtatctg gagtcccgga aggtacaggc gctagggctc tgagcccctc 8880
tcagtctctc cagctccact ctcaggcctg tggcattcaa tgtcccgact tctccctctc 8940
tgctcttttt catgacccca cctcagtgtc cccaggcatt cacgctttcc tgcattcccc 9000
actcgttcct cacccttccc cagaggggag aggggacgca ggagaaggca ctccccgttt 9060
ctaaaccttg acctcctcct ctgtaaagtg ggtggagggc ccctgccccc gggcctgctg 9120
gggggtggtg tgtgctcaac tccaggccag gtgtcctgag gcacccaagc ccccgctccc 9180
tgcagtgtat ccaccgggac ctggctgccc gcaatgtgct ggtgactgag gacaatgtga 9240
tgaagattgc tgactttggg ctggcccgcg gcgtccacca cattgactac tataagaaaa 9300
ccagcaacgt gagggagatg gggcagaact ggatgggggt ggaggggcac tgggcccggg 9360
gtggcaggca cgaggacctg tgggactctg cactgaggcc ctctctcccc tccagggccg 9420
cctgcctgtg aagtggatgg cgcccgaggc cttgtttgac cgggtgtaca cacaccagag 9480
tgacgtgtga gtcctgccgg cggtcactgt cctaccccac aaaaagggca aggcactgcc 9540
caaagtcacg tggccccagg agtcatgcgc tcgagggctc cttcagattt ggtctgggac 9600
ccgagtgggc ccagactcca ggaggagccc attccccaac agctgtggtg ggtcatgtct 9660
gtggggtccc ccgtcctagc cccggtcgtc gggagggcgc tgagccacac tgagccctgg 9720
ccctacctcc aggtggtctt ttgggatcct gctatgggag atcttcaccc tcgggggctc 9780
cccgtatcct ggcatcccgg tggaggagct gttctcgctg ctgcgggagg gacatcggat 9840
ggaccgaccc ccacactgcc ccccagagct gtgaggcctc accctgccct cgaccccact 9900
ttccagtcct cctcctcctc tgccctgacc atggcctcag ggtgtgtccc ggccagaagg 9960
acaacactaa caacaactcc tcgtcctcct cctcctcttc ctcttcctcc tcctcctctt 10020
cctcctcctc ctcttcctcc tcctcttcct cctcctcctc ttcctcctcc tcctcttcct 10080
ccttctcctc ctgctcctct tcctcctcct tctcttcctc ctcctcctct tcctcctcct 10140
cctcttcctc ctcctcctct tcctccttct cctcctgctc ctcttcctcc tccttctctt 10200
cctcctcctt ctcttcctcc tcctcctcct gctcctcttc ctcctcctcc tcttcctcct 10260
cctcagccta gtggagtgtc ctggcctggc ttctactgat gaccctccta tccctcatca 10320
aactccccac caaactcctc cccacccaga gaacccccgg tcctcccctt cctcctgaag 10380
gcctgaggct ccctgtgacc ctccgcccca cctctcgcag gtacgggctg atgcgtgagt 10440
gctggcacgc agcgccctcc cagaggccta ccttcaagca gctggtggag gcgctggaca 10500
aggtcctgct ggccgtctct gaggaggtac agcccctccc acccaccacc tccctctgcc 10560
tgctcccctc caggcctcat ctggcctgac cgcgtggaca tgcgccccgt cccatcccgg 10620
gcgctgcaga ggctgaccag ctccgttccc cacagtacct cgacctccgc ctgaccttcg 10680
gaccctattc cccctctggt ggggacgcca gcagcacctg ctcctccagc gattctgtct 10740
tcagccacga ccccctgcca ttgggatcca gctccttccc cttcgggtct ggggtgcaga 10800
catgagcaag gctcaaggct gtgcaggcac ataggctggt ggccttgggc cttggggctc 10860
agccacagcc tgacacagtg ctcgaccttg atagcatggg gcccctggcc cagagttgct 10920
gtgccgtgtc caagggccgt gcccttgccc ttggagctgc cgtgcctgtg tcctgatggc 10980
ccaaatgtca gggttctgct cggcttcttg gaccttggcg cttagtcccc atcccgggtt 11040
tggctgagcc tggctggaga gctgctatgc taaacctcct gcctcccaat accagcagga 11100
ggttctgggc ctctgaaccc cctttcccca cacctccccc tgctgctgct gccccagcgt 11160
cttgacggga gcattggccc ctgagcccag agaagctgga agcctgccga aaacaggagc 11220
aaatggcgtt ttataaatta tttttttgaa ataaagctct gtgtgcctgg g 11271
<210> 128
<211> 20
<212> DNA
<213> Homo sapiens
<400> 128
gagcgagctg agtggttgtg 20
<210> 129
<211> 22
<212> DNA
<213> Homo sapiens
<400> 129
tcgcgtctcg gaaaccggta gc 22
<210> 130
<211> 21
<212> DNA
<213> Homo sapiens
<400> 130
agtcagttgg tcagccatgc t 21
<210> 131
<211> 19
<212> DNA
<213> Homo sapiens
<400> 131
aggaggcgaa ttagtccga 19
<210> 132
<211> 22
<212> DNA
<213> Homo sapiens
<400> 132
tcgcgtctcg gaaaccggta gc 22
<210> 133
<211> 20
<212> DNA
<213> Homo sapiens
<400> 133
gctcttcagt cagttggtca 20
<210> 134
<211> 26
<212> DNA
<213> Homo sapiens
<400> 134
gggtgtttat tcctcatgga ctaatt 26
<210> 135
<211> 27
<212> DNA
<213> Homo sapiens
<400> 135
tggacaggac tgaacgtctt gctcgag 27
<210> 136
<211> 20
<212> DNA
<213> Homo sapiens
<400> 136
ggcctcccat ctccttcatc 20
<210> 137
<211> 20
<212> DNA
<213> Homo sapiens
<400> 137
gtatgcctgc cgtgtgaacc 20
<210> 138
<211> 25
<212> DNA
<213> Homo sapiens
<400> 138
agtgggatcg agacatgtaa gcagc 25
<210> 139
<211> 22
<212> DNA
<213> Homo sapiens
<400> 139
ggcatcttca aacctccatg at 22
<210> 140
<211> 21
<212> DNA
<213> Homo sapiens
<400> 140
tgtggttcct gcatgaagac a 21
<210> 141
<211> 18
<212> DNA
<213> Homo sapiens
<400> 141
tggctggcgg tgcctgga 18
<210> 142
<211> 24
<212> DNA
<213> Homo sapiens
<400> 142
gtgacagcgg aagtggtatt gtac 24
<210> 143
<211> 17
<212> DNA
<213> Homo sapiens
<400> 143
gccagccgag ccacatc 17
<210> 144
<211> 28
<212> DNA
<213> Homo sapiens
<400> 144
aaggtgaagg tcggagtcaa cggatttg 28
<210> 145
<211> 16
<212> DNA
<213> Homo sapiens
<400> 145
ccaggcgccc aatacg 16
<210> 146
<211> 20
<212> DNA
<213> Homo sapiens
<400> 146
tgccctgagc atcgaagagt 20
<210> 147
<211> 30
<212> DNA
<213> Homo sapiens
<400> 147
caggcctgga gataaagtcc ctccaattaa 30
<210> 148
<211> 19
<212> DNA
<213> Homo sapiens
<400> 148
attcttcccc agcgtttgg 19
<210> 149
<211> 23
<212> DNA
<213> Homo sapiens
<400> 149
cgtgaagatg ctgaaagacg atg 23
<210> 150
<211> 21
<212> DNA
<213> Homo sapiens
<400> 150
aaacgcttga agaggtcgga g 21
<210> 151
<211> 21
<212> DNA
<213> Homo sapiens
<400> 151
tgcctgtgga ggaacttttc a 21
<210> 152
<211> 20
<212> DNA
<213> Homo sapiens
<400> 152
cccaaactca gcagcctaag 20
<210> 153
<211> 20
<212> DNA
<213> Homo sapiens
<400> 153
aagacgatgc cactgacaag 20
<210> 154
<211> 24
<212> DNA
<213> Homo sapiens
<400> 154
cccagcaggt tgatgatgtt tttg 24
<210> 155
<211> 22
<212> DNA
<213> Homo sapiens
<400> 155
tccttctccg acctcttcaa gc 22
<210> 156
<211> 23
<212> DNA
<213> Homo sapiens
<400> 156
taatcctcca cgcacttctt cag 23
<210> 157
<211> 18
<212> DNA
<213> Homo sapiens
<400> 157
tacctggacc tgtcggcg 18
<210> 158
<211> 18
<212> DNA
<213> Homo sapiens
<400> 158
tgggcaaaca cggagtcg 18
<210> 159
<211> 25
<212> DNA
<213> Homo sapiens
<400> 159
ccacagacgc acaggattct aagtc 25
<210> 160
<211> 22
<212> DNA
<213> Homo sapiens
<400> 160
tgagttttcc agtccaaggg tg 22
<210> 161
<211> 19
<212> DNA
<213> Homo sapiens
<400> 161
ggtcctttgg ggtcctgct 19
<210> 162
<211> 23
<212> DNA
<213> Homo sapiens
<400> 162
atcttcacgc tggggggctc ccc 23
<210> 163
<211> 24
<212> DNA
<213> Homo sapiens
<400> 163
atcatgtaca ggtcgtgtgt gcag 24
<210> 164
<211> 18
<212> DNA
<213> Homo sapiens
<400> 164
cacatccgcg tgtgcctg 18
<210> 165
<211> 24
<212> DNA
<213> Homo sapiens
<400> 165
cgtgcgcatc ttgcctccag gtgc 24
<210> 166
<211> 22
<212> DNA
<213> Homo sapiens
<400> 166
gcccacttac attctgcact gg 22
Claims (31)
1.一种对患有尿路上皮癌或膀胱癌或具有发展尿路上皮癌或膀胱癌的风险的患者的样本进行分类的方法，所述方法包括以下步骤：
a)在来自所述患者的所述样本中确定：
·FGFR基因中存在或不存在改变和/或
·编码选自FGFR1、FGFR2、FGFR3或FGFR4的受体的至少一个基因的表达水平，和
b)将步骤a)的结果得到的所述患者的所述样本分类为至少两种分类中的一种。
2.根据权利要求1所述的方法，其中将步骤a)的结果得到的所述患者的所述样本分类为至少两种分类中的一种的步骤b)包括分类为以下一种：
(i)对于用抗癌剂的治疗的预后良好，或
(ii)对于用抗癌剂的治疗的预后不良。
3.根据权利要求1或2所述的方法，其中基于所述步骤b)中的分类，选择治疗模式，所述治疗模式选自以下一种：
(i)在对于用抗癌剂的治疗预后良好的情况下施用抗癌剂，或
(ii)在对于用抗癌剂的治疗预后不良好的情况下施用FGFR抑制剂。
4.根据前述权利要求任意一项所述的方法，其中所述表达水平通过以下至少一个来确定：
(i)基于杂交的方法，其中使用标记的单链探针，
(ii)基于PCR的方法，所述方法包括聚合酶链式反应(PCR)，
(iii)基于特定分子的电化学检测的方法，所述方法涵盖分子在产生可检测的信号的情况下结合的电极系统，
(iv)基于阵列的方法，其包括使用微阵列和/或生物芯片，和/或
(v)免疫学方法，其中使用一种或多种靶特异性蛋白结合剂。
5.根据前述权利要求任意一项所述的方法，其中所述FGFR基因中的改变通过以下来确定：
(i)确定改变的FGFR变体的表达水平，
(ii)确定至少以下的表达水平
·并入所述改变的FGFR变体的FGFR外显子，和
·没有并入所述改变的FGFR变体的FGFR外显子，
和将两者进行比较，和/或
(v)对所述相应的FGFR基因测序以鉴定各自的改变。
6.根据前述权利要求任意一项所述的方法，其中所述表达水平通过以下至少一项的实时聚合酶链式反应(RT-PCR或qPCR)来确定：
·FGFR野生型mRNA，和/或
·所述改变的FGFR变体的mRNA。
7.根据前述权利要求任意一项所述的方法，其特征在于：步骤a)中确定的一个或多个表达水平在步骤b)之前用一个或多个参考基因的一个或多个表达水平进行归一化，以获得一个或多个归一化的表达水平。
8.根据前述权利要求任意一项所述的方法，其特征在于所述一个或多个参考基因是至少一个管家基因。
9.根据权利要求8所述的方法，其中所述至少一个管家基因选自CALM2、B2M和/或RPL37A。
10.根据前述权利要求任意一项所述的方法，其特征在于确定选自KRT5、ERBB2、KRT20、PD1和/或PD-L1的至少一个以上基因的表达水平，以及任选地进行归一化。
11.根据前述权利要求任意一项所述的方法，其特征在于所述尿路上皮癌或膀胱癌是T2、T3或T4期癌症。
12.根据前述权利要求任意一项所述的方法，其中所述步骤b)中的分类依赖于FGFR2和/或FGFR3的表达水平。
13.根据前述权利要求任意一项所述的方法，其中所述步骤b)中的分类分别依赖于FGFR2和FGFR3的表达水平之间的比值或其归一化的表达水平。
14.根据前述权利要求任意一项所述的方法，其中所述步骤b)中的分类依赖于存在或不存在FGFR基因中的改变，优选FGFR3基因中的改变。
15.根据前述权利要求任意一项所述的方法，其中用二氧化硅包被的磁性颗粒和离液盐处理所述样本，以在步骤a)中的确定之前纯化所述样本中所含的核酸。
16.根据前述权利要求任意一项所述的方法，其中所述抗癌剂包括至少一种化疗剂。
17.根据前述权利要求任意一项所述的方法，其中所述抗癌剂包括免疫检查点抑制剂。
18.根据权利要求17所述的方法，其中所述免疫检查点抑制剂是选自以下的至少一种：
·PD-1抑制剂
·PD-L1抑制剂
·CTLA-4抑制剂
·LAG 3抑制剂
·TIM3抑制剂，和/或
·OX40抑制剂。
19.根据权利要求17或18所述的方法，其中所述免疫检查点抑制剂是选自以下的至少一种：
·抗体，
·修饰的抗体形式，
·保留靶结合特性的抗体衍生物或片段
·基于抗体的结合蛋白，
·寡肽结合剂和/或
·抗体模拟物。
20.根据前述权利要求任意一项所述的方法，其中所述免疫检查点抑制剂是选自如表5所述的至少一种。
21.根据前述权利要求任意一项所述的方法，其中所述FGFR抑制剂是FGFR酪氨酸激酶抑制剂。
22.根据前述权利要求任意一项所述的方法，其中所述FGFR抑制剂是选自如表6所述的至少一种。
23.包含至少一种核苷酸序列的寡核苷酸，其能够与以下杂交：
a)编码FGFR1、FGFR2、FGFR3或FGFR4中任何一项的核酸分子或改变的FGFR基因，或
b)编码FGFR1、FGFR2、FGFR3或FGFR4中任何一项或其同种型或改变的FGFR的mRNA，
所述寡核苷酸选自以下：
-扩增引物(正向和/或反向)
-标记的探针，和/或
-底物结合的探针，
用于制备用于进行根据前述权利要求任意一项所述方法的试剂盒。
24.包含至少一种如权利要求21所述的寡核苷酸的试剂盒。
25.根据权利要求24所述的试剂盒，所述试剂盒包括：
a)能够与编码FGFR2的核酸分子杂交的正向/反向引物组，加上任选地合适探针，以及
b)能够与编码FGFR3的核酸分子杂交的正向/反向引物组，加上任选地合适探针。
26.根据权利要求25所述的试剂盒，所述试剂盒还包括能够检测FGFR3-TACC3融合蛋白存在的引物组。
27.根据权利要求24所述的试剂盒，所述试剂盒包括：
a)能够与编码FGFR2的核酸分子杂交的正向/反向引物组，和
b)能够检测FGFR3-TACC3融合蛋白存在的引物组。
28.根据权利要求26-27任意一项所述的试剂盒，其中能够检测FGFR3-TACC3融合蛋白存在的引物组包括：
a)能够与位于FGFR3和TACC3之间的融合位点的N端的FGFR3外显子中的核酸分子杂交的正向引物，和能够与位于FGFR3和TACC3之间的融合位点的C端的TACC3外显子中的核酸分子杂交的反向引物，
b)能够与编码FGFR3的N端区域的核酸分子杂交的正向引物和能够与编码FGFR3的N端区域的核酸分子杂交的反向引物，加上能够与编码FGFR3的C端区域的核酸分子杂交的正向引物和能够与编码FGFR3的C端区域的核酸分子杂交的反向引物，
c)能够与编码TACC3的C端区域的核酸分子杂交的正向引物和能够与编码TACC3的N端区域的核酸分子杂交的反向引物，加上能够与编码TACC3的N端区域的核酸分子杂交的正向引物和能够与编码TACC3的N端区域的核酸分子杂交的反向引物，和/或
d)能够与位于FGFR3和TACC3之间的融合位点的N端的FGFR3外显子中的核酸分子杂交的正向引物，和能够与位于FGFR3和TACC3之间的融合位点的C端的FGFR3外显子中的核酸分子杂交的反向引物。
29.根据前述权利要求任意一项所述的试剂盒，所述试剂盒包括引物/探针组，其包括：
a)正向引物和反向引物，和任选地探针，如表1所示，以及正向引物和反向引物，和任选地探针，如表2所示，
b)a)的引物和任选地探针，以及至少地正向引物和反向引物，和任选地探针，如表3所示，
c)正向引物和反向引物，和任选地探针，如表1所示，以及至少地正向引物和反向引物，和任选地探针，如表3所示。
30.根据前述权利要求任意一项所述的试剂盒，所述试剂盒包括标记的探针，所述标记的探针用一种或多种荧光分子、发光分子、放射性分子、酶分子和/或猝灭分子标记。
31.根据前述权利要求任意一项所述的寡核苷酸或试剂盒在将患有尿路上皮癌或膀胱癌或具有发展尿路上皮癌或膀胱癌的风险的患者的样本分类为至少两种分类之一的方法中的用途。
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| EP19168923.1 | 2019-04-12 | ||
| EP19168923 | 2019-04-12 | ||
| PCT/EP2020/060456 WO2020208260A1 (en) | 2019-04-12 | 2020-04-14 | Method of classifying a sample based on determination of fgfr |
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| DE10058397A1 (de) | 2000-11-24 | 2002-06-06 | Siemens Ag | Anordnung für ein elektrochemisches Analyseverfahren und deren Verwendung |
| DE10058394C1 (de) | 2000-11-24 | 2002-07-11 | Siemens Ag | Verfahren für die biochemische Analytik und zugehörige Anordnung |
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