KR101818352B1 - 방광암의 진단 및 예후 예측용 바이오 마커 및 그의 용도 - Google Patents

방광암의 진단 및 예후 예측용 바이오 마커 및 그의 용도 Download PDF

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KR101818352B1
KR101818352B1 KR1020160082434A KR20160082434A KR101818352B1 KR 101818352 B1 KR101818352 B1 KR 101818352B1 KR 1020160082434 A KR1020160082434 A KR 1020160082434A KR 20160082434 A KR20160082434 A KR 20160082434A KR 101818352 B1 KR101818352 B1 KR 101818352B1
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bladder cancer
gene
progression
seq
present
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김원재
윤석중
강호원
정필두
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충북대학교 산학협력단
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Abstract

본 발명은 방광암의 진행(progression)과 관련된 8개의 유전자 조합으로 이루어진 바이오 마커 및 이의 용도에 관한 것이다. 본 발명에 따른 8개의 방광암 진행 관련 유전자들을 이용하여 개발된 방광암 위험도 산출 모델은 방광암의 재발과 병기의 진행을 효과적으로 예측할 수 있음이 임상적으로 확인되었다. 따라서 상기 유전자들로 구성된 바이오마커 세트는 방광암 진단 및 예후 측정용 마커로 이용될 수 있으며, 이를 통해 높은 정확성과 신뢰도로 방광암을 진단하거나 그 예후를 예측할 수 있을 뿐만 아니라 방광암 치료제를 효과적으로 스크리닝하는데 이용될 수 있다.

Description

방광암의 진단 및 예후 예측용 바이오 마커 및 그의 용도{Biomarkers for diagnosis and prognosis of bladder cancer and uses thereof}
본 발명은 방광암의 진단 및 예후 예측용 바이오 마커에 관한 것으로, 보다 구체적으로 방광암의 진행(progression)과 관련된 8개의 유전자 조합으로 이루어진 바이오 마커, 이를 이용한 방광암 진단 또는 예후 예측용 조성물, 키트, 방광암 진단 또는 예후 예측을 위한 정보제공방법 및 방광암 치료제의 스크리닝 방법에 관한 것이다.
방광암은 비뇨기계 종양 중 전립선암 다음으로 높은 사망률을 보이는 악성종양이다. 방광암의 90% 이상은 이행상피세포암이며, 그 가운데 60% 정도는 저등급 분화도의 표재성 방광암이다. 하지만 요도경유절제술을 시행한 경우 재발이 빈번하며 16-25% 정도는 고등급 분화도의 암으로 진행하고 또한 10%의 경우에서는 병기의 진행 및 종양의 전이가 발생한다. 이러한 잦은 재발과 병기의 진행은 방광암 환자 및 비뇨기과 의사에게 자주 제기되는 문제점이며, 따라서 방광암의 재발을 예방하고 침윤성으로 진행되는 것을 억제하는데 더욱 효과적인 예후 지표의 발견이나 치료법의 개발이 필요한 실정이다.
현재까지 많은 연구에도 불구하고 방광암의 정확한 원인이 규명되지 않았으나, 흡연, 발암물질의 노출, 약물복용 등이 방광암의 위험인자로 보고되고 있다. 방광암의 중요한 숙주요인으로 원발성 종양유전자와 종양 억제유전자의 돌연변이, 특정 대립유전자 사이의 이형접합결손, 특정 유전자의 촉진자 부위 메틸화 양상 등이 있다. 유두상의 분화가 좋은 Ta 병기의 표재성 방광암의 재발률은 50-75%로 암의 재발이 많더라도 근육층을 침범하는 침윤성 방광암으로의 진행은 15% 미만이다. 반면에 고유층을 침범하는 T1 병기의 대부분은 분화도가 나쁘고 상피내암을 자주 동반하며 30-50%에서 여러 가지 치료법에도 불구하고 침윤성 내지는 전이성 암으로 진행된다. 분화도가 나쁜 Ta 병기에서는 분화도가 좋은 Ta 병기보다 10-15% 정도의 병기 진행의 위험이 있지만 T1 병기보다는 그 위험도가 낮다. 또한 진단 당시 약 30%에서 이미 근육층을 침범한 침윤성 종양으로 진단되고, 그 중 50% 이상이 이미 원격전이가 있는 상태이다.
이처럼 방광암은 여러 생물학적 다양성을 보이며, 현재 임상적인 예후인자로 사용되고 있는 것은 종양의 분화도, 방광 고유층의 침윤 여부(종양의 병기), 혈관 혹은 림프관 침윤여부, 상피내암의 존재 여부 등이 있으나, 같은 병리학적 특성 내에서도 생물학적 다양성은 아직 완전히 이해되지 않고 있는 실정이다. 표재성 혹은 침윤성 방광암의 내재된 생물학적 특성과 재발 혹은 진행의 위험도를 예측하는 것이 치료방침의 결정에 매우 중요하다고 볼 수 있다. 특히 표재성 방광암 환자에서 재발 및 진행의 위험성이 높은 고위험 환자를 선별하여 보다 적극적인 치료를 시행하는 것이 환자의 예후 향상에 많은 도움을 줄 수 있다.
세포유전학적 연구를 통해서 방광 이행세포암에서 수많은 구조적 변화나 염색체 이상들이 밝혀지고 있다. 염색체수의 증가(hyperdiploidy) 또는 감소(aneuploidy), 표지 염색체들, 염색체 크기나 모양의 변화와 같은 염색체 이상 등이방광암의 재발 및 진행의 위험성 증가와 밀접한 관계가 있다. 방광암의 분자 유전학적 연구들에 의해 특히 3p, 6q, 9q, 11p, 17p, 및 18q와 같은 몇몇 염색체의 완(arm)들의 결손이 밝혀졌다. 9q 결손이 고분화 및 저분화 방광암에서 모두 관찰된다는 사실은 9q의 결손이 방광암 발생 과정의 첫 번째 변화일 가능성을 시사한다. 그 밖에도 표재성 방광암의 초기 변화들 중에는 11p, 8p의 결손과 8q, 1q의 추가도 관찰되고 있다. 이와는 반대로 17p의 결손은 표재성 방광암에서는 관찰되지 않지만, 침윤성 방광암의 약 60%에서 17p의 이형 접합성 소실(loss of heterozygosity; LOH)을 보인다는 사실은 이 부위의 소실이 방광암의 진행에 관여함을 암시한다.
한편 새로운 고처리량(high-throughput) 마이크로어레이 기술은 인간의 질병을 분자적 시각에서 이해가 가능하도록 하고 있다. 인체 종양에서 다양하게 발현되는 유전자들에 대한 연구는 과거와는 달리 DNA 마이크로어레이 기술에 의해 비교적 쉽게 이루어질 수 있다. 이 방법을 이용하면 종양 내에서 발현되는 수백 또는 수천 가지 유전자들의 RNA 발현 정도를 동시에 조사할 수 있다. 이뿐 아니라 최근에는 조직 마이크로어레이 기술이 개발되어 수백 가지의 종양에서 동시에 광범위한 분자유전학적 분석도 가능하게 되었다.
이에 본 발명자들은 비근육 침윤성 방광암 환자 조직 마이크로어레이 방법을 통해 방광암의 진행을 예측할 수 있는 유전자 클러스터(cluster)를 선별하여 위험도를 산출하는 모델을 개발하고 개발된 모델을 장기간 임상데이터로 증명함으로써 본 발명을 완성하였다.
대한민국 공개특허 제10-2015-0113561호 대한민국 등록특허 제10-1557183호
Babjuk M, Oosterlinck W, Sylvester R, et al: Guidelines on non-muscle-invasive bladder cancer (TaT1 and CIS). 2011. Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Bohle A and Palou-Redorta J: EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder. European urology 54: 303-314, 2008. SMITH JA, LABASKY RF, COCKETT AT, FRACCHIA JA, MONTIE JE and ROWLAND RG: Bladder cancer clinical guidelines panel summary report on the management of nonmuscle invasive bladder cancer (stages Ta, T1 and TIS). The Journal of urology 162: 1697-1701, 1999.
본 발명의 목적은 방광암의 진행(progression)과 관련된 특정 유전자 조합으로 이루어진 방광암 진단 마커용 조성물을 제공하는 것이다.
본 발명의 다른 목적은 상기 유전자 바이오 마커를 이용한 방광암 진단 및 예후 예측용 조성물 및 키트를 제공하는 것이다.
본 발명의 다른 목적은 상기 유전자 바이오마커를 이용하여 방광암 진단 및 예후 예측을 위한 정보제공방법을 제공하는 것이다.
본 발명의 또다른 목적은 상기 유전자 바이오마커를 이용한 방광암 치료제의 스크리닝 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자를 포함하는 방광암 진단을 위한 마커용 조성물을 제공한다. 상기 유전자들은 마이크로어레이 유전자 발현 프로파일링을 통해 선별된 것으로 방광암의 진행(progression)과 관련되어 있으며, 특히 비근육침윤성 방광암의 예후 진단에 효과적이다.
COCH(coagulation factor C homolog, 서열번호 1, NC_000014.9)는 Cytogenetic location:14q12이고, CELSR3(cadherin EGF LAG seven-pass G-type receptor 3, 서열번호 2, NM_001407.2): Cytogenetic location: 3p21.31이며, HMOX1(heme oxygenase 1, 서열번호 3, CR456505.1): Cytogenetic location: 22q12.3이고, KIF1A(kinesin family member 1A, 서열번호 4, NC_000002.12): Cytogenetic location: 2q37.3이며, MGC17624(C16orf74, chromosome 16 open reading frame 74, 서열번호 5, NC_000016.10)이고, MTAP(methylthioadenosine phosphorylase, 서열번호 6, NM_002451.3): Cytogenetic location: 9p21.3이며, PFKB4(PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, 서열번호 7, FB711100.1): Cytogenetic location: 3p21.31이고, S100A8(S100 calcium binding protein A8, 서열번호 8, NC_000001.11): Cytogenetic location: 1q21.3이다.
본 발명의 일 양태로서, 본 발명은 상기 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자의 발현 수준을 측정하는 물질을 포함하는 방광암 진단 및 예후 예측용 조성물을 제공한다.
본 발명의 일례에 따르면, 상기 유전자의 발현 수준을 측정하는 물질은 상기 유전자가 전사하는 mRNA, 상기 유전자가 암호화하는 단백질, 또는 양자 모두의 존재 여부, 존재량 및 존재 패턴 중에서 어느 하나 이상을 검출하는 물질인 것을 특징으로 한다.
본 발명의 일례에 따르면, 상기 유전자의 발현 수준을 측정하는 물질은 상기 유전자의 뉴클레오타이드 서열, 그에 상보적인 서열, 상기 뉴클레오타이드의 단편 및 그에 상보적인 서열로 이루어진 군에서 선택된 어느 하나 이상에 특이적으로 결합하는 프라이머, 프로브, 앱타머 및 안티센스 중 어느 하나 이상인 것을 특징으로 한다.
본 발명의 일례에 따르면, 상기 유전자의 발현 수준을 측정하는 물질은 상기 뉴클레오타이드 서열에 코딩되는 폴리펩타이드, 상기 상보적인 서열에 코딩되는 폴리펩타이드, 상기 뉴클레오타이드 서열의 단편에 코딩되는 폴리펩타이드 중 어느 하나 이상에 특이적으로 결합하는 올리고펩타이드, 모노클로날 항체, 폴리클로날 항체, 키메릭(chimeric) 항체, 항체단편, 리간드, PNA(Peptide nucleic acid), 앱타머(aptamer), 아비머(avidity multimer) 및 펩티도모방체(peptidomimetics) 중에서 선택된 어느 하나 이상인 것을 특징으로 한다.
본 발명의 일례에 따르면, 상기 유전자의 발현 수준을 측정하는 물질은 상기 바이오마커 유전자가 암호화하는 단백질 및 상기 유전자가 전사하는 mRNA의 결합체의 존재 여부, 존재량 및 존재 패턴 중에서 어느 하나 이상을 검출하는 물질인 것을 특징으로 한다.
본 발명의 일례에 따르면, 상기 유전자의 발현 수준을 측정하는 물질은 역전사 중합효소연쇄반응, 경쟁적 중합효소 연쇄반응, 실시간 중합효소 연쇄반응, 정량적 중합효소 연쇄반응, Nuclease 보호 분석(RNase, S1 nuclease assay), in situ 교잡법, DNA 마이크로어레이 이용법, 노던 블랏, 웨스턴 블랏, ELISA(Enzyme Linked Immuno Sorbent Assay), 방사선 면역분석법, 면역 확산법, 면역 전기영동, 조직 면역염색, 면역침전 분석법, 보체 고정 분석법, FACS, 질량분석법(Mass spectrometry) 및 단백질 마이크로어레이 이용법 중에서 어느 하나 이상의 방법으로 유전자 발현을 측정하는 검출시약일 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 다른 양태로서, 본 발명은 상기 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자의 발현수준을 측정하는 물질을 포함하는 방광암 진단 및 예후 예측용 키트를 제공한다.
본 발명의 일례에 따르면, 상기 키트는 RT-PCR 키트, DNA 칩 키트 또는 단백질 칩 키트, 마이크로어레이, 유전자 증폭 키트, 면역분석(immunoassay)용 키트, 루미넥스 분석 키트, 단백질 마이크로어레이 키트, ELISA 키트 등일 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 다른 양태로서, 본 발명은 대상체로부터 얻은 시료로부터 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자의 발현 수준을 측정하는 단계; 상기 측정된 유전자들의 발현 수준을 이용하여 진행 위험도(progression risk score)를 계산하는 단계; 및 상기 진행 위험도를 이용하여 대상체의 방광암 진행 정도를 확인하는 단계를 포함하는 방광암 진단 및 예후 예측을 위한 정보제공방법을 제공한다.
본 발명의 일례에 따르면, 상기 방광암 진행 정도를 확인하는 단계는 상기 대상체의 진행 위험도를 대조군들로부터 얻은 참조 진행 위험도와 비교하는 것일 수 있다.
본 발명의 일례에 따르면, 상기 진행 위험도를 계산하는 단계는, 상기 측정된 유전자들의 발현 수준을 대수적으로 변환하여 각각의 측정된 유전자에 대해 변환된 값을 생성하는 단계; 상기 변환된 값에 각각의 유전자에 대한 상수를 곱하는 단계; 및 상기 곱한 값들을 합하여 진행 위험도를 계산하는 단계를 포함한다.
본 발명의 일례에 따르면, 상기 진행 위험도를 계산하는 단계에서 각각의 유전자에 대한 상수는 Cox 회귀 분석을 통해 구한 COX 회귀계수(Cox coefficient)일 수 있으며, 이 경우 진행 위험도(progression risk score)는 하기 식에 의해 계산될 수 있다.
Progression risk score = ∑ Cox coefficient of gene Gi × expression value of gene Gi
본 발명의 일례에 따르면, 상기 진행 위험도는 하기 식에 따라 계산할 수 있다.
Progression risk score = log2(COCH expression) x 0.1739 + log2(CELSR3 expression) x 0.2199 + log2(HMOX1 expression) x 0.2239 + log2(KIF1A expression) x 0.0582+ log2(MGC17624 expression) x -0.4004 + log2(MTAP expression) x -0.0987 + log2(PFKB4 expression) x 0.3364 + log2(S100A8 expression) x 0.1621
본 발명의 일례에 따르면, 상기 유전자의 발현 수준 측정은 역전사 중합효소연쇄반응, 경쟁적 중합효소 연쇄반응, 실시간 중합효소 연쇄반응, 정량적 중합효소 연쇄반응, Nuclease 보호 분석(RNase, S1 nuclease assay), in situ 교잡법, DNA 마이크로어레이 이용법, 노던 블랏, 웨스턴 블랏, ELISA(Enzyme Linked Immuno Sorbent Assay), 방사선 면역분석법, 면역 확산법, 면역 전기영동, 조직 면역염색, 면역침전 분석법, 보체 고정 분석법, FACS, 질량분석법(Mass spectrometry) 또는 단백질 마이크로어레이 이용법 등으로 수행할 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 일례에 따르면, 상기 방광암은 비근육침윤성 방광암인 것이 바람직하다.
본 발명의 또다른 양태로서, 본 발명은 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자가 발현되는 세포 또는 실험동물에 대상물질을 처리하는 단계; 상기 유전자들의 발현 수준을 측정하는 단계; 및 상기 측정된 유전자들의 발현 수준을 이용하여 상기 진행 위험도(progression risk score)를 계산하는 단계를 포함하는 방광암 치료제의 스크리닝 방법을 제공한다.
본 발명의 일례에 따르면, 상기 스크리닝 방법은 대상물질 처리에 의해 상기 계산된 진행 위험도가 대상물질 처리 전의 것보다 낮아진 경우 대상물질을 방광암 치료제 후보군으로 판정하는 단계를 더 포함할 수 있다.
본 발명의 일례에 따르면, 상기 유전자의 발현 수준 측정은 상술한 측정 방법을 사용하여 수행할 수 있다.
본 발명에 따른 8개의 방광암 진행 관련 유전자들을 이용하여 개발된 방광암 위험도 산출 모델은 방광암의 재발과 병기의 진행을 효과적으로 예측할 수 있음이 임상적으로 확인되었다. 따라서 상기 유전자들로 구성된 바이오마커 세트는 방광암 진단 및 예후 측정용 마커로 이용될 수 있으며, 이를 통해 높은 정확성과 신뢰도로 방광암을 진단하거나 그 예후를 예측할 수 있을 뿐만 아니라 방광암 치료제를 효과적으로 스크리닝하는데 이용될 수 있다.
도 1은 비근육침윤성 방광암 환자에서 progression risk score를 통한 질병 진행도의 예측을 위한 ROC 곡선을 나타낸 것이다(AUC= 0.769, P < 0.001).
도 2는 비근육침윤성 방광암 환자에서 progression risk score를 통한 질병 진행의 예측을 위한 카플란-마이어 생존 곡선(Kaplan-Meier survival curve)을 나타낸 것이다(P < 0.001).
본 발명은 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자의 방광암 진단 또는 예후 예측용 바이오마커로서의 용도에 관한 것이다.
본 발명자들은 방광암의 진행 및 재발을 포함한 예후를 정확하고 효과적으로 예측할 수 있는 방광암 위험도 산출 모델을 개발하고자 연구한 결과, 본 발명의 바이오마커 유전자들을 이용한 위험도 산출 모델이 방광암의 재발과 병기의 진행을 효과적으로 예측할 수 있음을 입증함으로써 본 발명을 완성하였다.
본 명세서에서 용어 "진단"은 병리 상태의 존재 또는 특징을 확인하는 것을 의미한다. 본 발명의 목적상 상기 진단은 방광암, 특히 비근육침윤성 방광암(Non-muscle Invasive Bladder Cancer; NMIBC)의 예후를 예측 또는 확인하는 것을 의미한다. "예후(Prognosis)"란 질병의 경과와 결과의 예측을 의미하는 것으로, 본 발명에서는 방광암의 재발(Recurrence) 및 진행(progression)을 예측하는 것을 포함한다. “진단용 마커 또는 진단 마커(diagnosis marker)”란 방광암 세포를 정상 세포와 구분하여 진단할 수 있는 물질로, 정상 세포에 비하여 방광암을 가진 세포에서 증가양상을 보이는 폴리펩타이드 또는 핵산(예: mRNA 등), 지질 , 당지질, 당단백질, 당(단당류, 이당류, 다당류 등) 등과 같은 유기 생체 분자 등을 포함한다. 본 발명의 목적상, 방광암 예후 진단 마커는 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자로 이들은 (비근육침윤성) 방광암의 진행과 높은 상관관계를 나타낸다.
본 명세서에서 "대상 또는 대상체"는 인간, 소, 개, 기니아 피그, 토끼, 닭, 곤충 등을 포함하여 치료가 요구되는 임의의 단일 개체를 의미한다. 또한, 임의의 질병 임상 소견을 보이지 않는 임상 연구 시험에 참여한 임의의 대상 또는 역학 연구에 참여한 대상 또는 대조군으로 사용된 대상이 대상에 포함된다.
본 명세서에서 "조직 또는 세포 시료"는 대상 또는 환자의 조직으로부터 얻은 유사한 세포의 집합체를 의미한다. 조직 또는 세포 샘플의 공급원은 신선한, 동결된 및/또는 보존된 장기 또는 조직 샘플 또는 생검 또는 흡인물로부터의 고형조직; 혈액 또는 임의의 혈액 구성분; 대상의 임신 또는 발생의 임의의 시점의 세포일 수 있다. 조직 샘플은 또한 1차 또는 배양 세포 또는 세포주일 수 있다.
본 명세서에서 사용되는 “폴리펩타이드(또는 단백질)”는 해당 아미노산 서열에 대하여 실질적인 동일성을 나타내는 아미노산 서열을 포함하는 것으로 해석된다. 상기의 실질적인 동일성은 본 발명의 아미노산 서열과 임의의 다른 서열을 최대한 대응되도록 얼라인하고, 당업계에서 통상적으로 사용되는 알고리즘을 이용하여 얼라인된 서열을 분석한 경우에, 최소 60%의 상동성, 보다 바람직하게는 최소 80%의 상동성, 가장 바람직하게는 최소 90%의 상동성을 나타내는 아미노산 서열을 의미하나 이에 제한되는 것은 아니며, 일반적으로, 동일성 % 는 높을수록 더욱 바람직하다. 또한 상기 동일성을 가지는 폴리펩타이드는 기재된 특정 아미노산 서열의 폴리펩타이드에서 1개 이상 아미노산 잔기가 소실, 치환, 삽입, 및/또는 첨가된 아미노산 서열을 포함하면서 베타-아디페이트 경로와 관련되는 폴리펩타이드를 포함한다. 일반적으로, 소실, 치환, 삽입, 및/또는 첨가의 수는 적을수록 더욱 바람직하다.
본 명세서에 사용되는 “폴리뉴클레오타이드(또는 뉴클레오타이드, 핵산)”는 DNA(gDNA 및 cDNA) 그리고 RNA 분자를 포괄적으로 포함하는 의미를 가지며, 핵산 분자에서 기본 구성 단위인 뉴클레오타이드는 자연의 뉴클레오타이드 뿐만 아니라, 당 또는 염기 부위가 변형된 유사체(analogues)도 포함한다.
본 발명의 폴리뉴클레오타이드는 상기 기재된 특정의 아미노산 서열(폴리펩타이드)을 암호화하는 핵산 분자에 제한되지 않고, 상기에서 서술한 것처럼 특정 아미노산 서열에 대하여 실질적인 동일성을 나타내는 아미노산 서열 또는 그에 상응하는 기능을 갖는 폴리펩타이드를 암호화하는 핵산 분자를 포함하는 것으로 해석된다. 상기의 실질적인 동일성은 본 발명의 아미노산 서열과 임의의 다른 서열을 최대한 대응되도록 얼라인하고, 당업계에서 통상적으로 사용되는 알고리즘을 이용하여 얼라인된 서열을 분석한 경우에, 최소 60%의 상동성, 보다 바람직하게는 최소 80%의 상동성, 가장 바람직하게는 최소 90%의 상동성을 나타내는 아미노산 서열을 의미하나 이에 제한되는 것은 아니다.
상기 상응하는 기능을 가진 폴리펩타이드는 예를 들어, 하나 이상의 아미노산이 소실, 치환, 삽입, 및/또는 첨가되는 아미노산 서열의 폴리펩타이드를 포함한다. 그러한 폴리펩타이드는 상기 상술한 것처럼 1 개 이상의 아미노산 잔기가 소실, 치환, 삽입, 및/또는 첨가된 아미노산 서열로 이루어지며 3-하이드록시프로피온산 합성 관련되는 폴리펩타이드를 포함하며, 아미노산 잔기의 소실,치환,삽입, 및/또는 첨가의 수가 적은 것이 바람직하다. 또한, 상기 폴리펩타이드는 상기 상술한 것처럼 기재된 특정의 아미노산 서열과 약 60% 이상의 동일성을 갖는 아미노산 서열을 가지며 방광암 진단 또는 예후 추정의 바이오 마커 기능을 하는 폴리펩타이드를 포함하며, 동일성이 높을 수록 바람직하다.
본 명세서에서 사용되는 용어 "상보적" 또는 "상보성"은 퓨린 및 피리미딘 뉴클레오티드가 수소 결합을 통해 결합하여 더블 스트랜드 폴리뉴클레오타이드를 형성하는 능력을 의미하며, 부분적으로 상보적인 경우도 포함한다. 하기 염기쌍이 상보성과 관련된다: 구아닌 및 시토신; 아데닌 및 티민; 및 아데닌 및 우라실. "상보적"은 상기 언급된 관계가 전장의 상기 분자에 걸쳐 2개의 싱글-스트랜드 폴리뉴클레오타이드를 포함하는 모든 염기쌍에 실질적으로 적용된다. "부분적으로 상보적"은 2개의 싱글-스트랜드 폴리뉴클레오타이드 중 하나의 길이가 짧기 때문에 그 분자들 중 하나의 일부가 싱글 스트랜드로 남아있는 것 관계를 의미한다.
본 발명은 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자의 발현 수준을 측정하는 물질을 포함하는 방광암 진단 또는 예후 예측용 조성물을 제공한다.
본 발명에 따른 방광암 진단 또는 예후 측정용 조성물은 상기 각 유전자의 발현을 측정하는 물질을 각각 포함하거나, 또는 상기 유전자들의 발현을 동시에 측정하는 물질일 수 있다.
본 발명에서 발현 측정(또는 검출)이란 정량 및/또는 정성 분석을 포함하는 것으로, 존재, 부존재의 검출 및 발현량 검출을 포함하는 것으로 이러한 방법은 당업계에 공지되어 있으며, 당업자라면 본원의 실시를 위해 적절한 방법을 선택할 수 있을 것이다.
본 발명에서 상기 유전자의 발현 수준을 측정하는 물질은 상기 유전자가 전사하는 mRNA, 상기 유전자가 암호화하는 단백질, 또는 양자 모두의 존재 여부, 존재량 및 존재 패턴 중에서 어느 하나 이상을 검출하는 물질일 수 있다. 본 발명은 상기 유전자를 핵산 수준 특히 mRNA 수준에서 정량적 및/또는 정성적 검출을 통해 간세포암의 진단 또는 예후 측정에 사용될 수 있다.
본 발명에서 상기 유전자의 발현 수준을 측정하는 물질은 상기 유전자의 뉴클레오타이드 서열, 그에 상보적인 서열, 상기 뉴클레오타이드의 단편 및 그에 상보적인 서열로 이루어진 군에서 선택된 어느 하나 이상에 특이적으로 결합하는 프라이머, 프로브, 앱타머 및 안티센스 중 어느 하나 이상일 수 있다.
일례로, 상기 유전자의 mRN의 존재 여부와 그 양 또는 패턴을 RT-PCR로 측정하기 위하여, 상기 유전자의 mRNA에 특이적인 프로브 및/또는 프라이머쌍를 포함한다. 프라이머 또는 프로브는 주형과 상보적으로 결합할 수 있고 역전사효소 또는 DNA 중합효소가 주형의 복제를 개시할 수 있도록 하는 자유 3말단 수산화기(free 3' hydroxyl group)를 가지는 핵산 서열을 의미한다. 본원에 사용되는 상기 유전자 발현 측정 물질은 신호검출을 위해 발색, 발광 또는 형광물질과 같은 것으로 표지될 수 있다. 일례로, mRNA 검출을 위해 노던블랏 또는 역전사 PCR (중합효소연쇄반응)이 사용된다. 후자의 경우 검체의 RNA를 특히 mRNA를 분리한 후, 이로부터 cDNA를 합성한 후, 특정 프라이머, 또는 프라이머 및 프로브의 조합을 사용하여, 검체 중의 특정 유전자를 검출하는 것으로, 특정 유전자의 존재/부존재 또는 발현량을 결정할 수 있는 방법이다.
본 발명에서 상기 유전자의 발현 수준을 측정하는 물질은 상기 뉴클레오타이드 서열에 코딩되는 폴리펩타이드, 상기 상보적인 서열에 코딩되는 폴리펩타이드, 상기 뉴클레오타이드 서열의 단편에 코딩되는 폴리펩타이드 중 어느 하나 이상에 특이적으로 결합하는 올리고펩타이드, 모노클로날 항체, 폴리클로날 항체, 키메릭(chimeric) 항체, 항체단편, 리간드, PNA(Peptide nucleic acid), 앱타머(aptamer), 아비머(avidity multimer) 및 펩티도모방체(peptidomimetics) 중에서 선택된 어느 하나 이상일 수 있다.
본 발명에서 상기 유전자의 발현 수준을 측정하는 물질은 상기 본 발명의 유전자가 암호화하는 단백질 및 상기 유전자가 전사하는 전령 RNA(mRNA)의 결합체의 존재 여부, 존재량 및 존재 패턴 중에서 어느 하나 이상을 검출하는 물질일 수 있다.
본 발명에서 상기 유전자의 발현 수준을 측정하는 물질은 당해 분야에서 공지된 다양한 유전자(바이오 마커) 검출 방법에 사용되는 물질을 포함할 수 있으며, 예를 들어, 역전사 중합효소연쇄반응, 경쟁적 중합효소 연쇄반응, 실시간 중합효소 연쇄반응, Nuclease 보호 분석(RNase, S1 nuclease assay), in situ 교잡법, DNA 마이크로어레이 이용법, 노던 블랏, 웨스턴 블랏, ELISA(Enzyme Linked Immuno Sorbent Assay), 방사선 면역분석법, 면역 확산법, 면역 전기영동, 조직 면역염색, 면역침전 분석법, 보체 고정 분석법, FACS, 질량분석법(Mass spectrometry) 및 단백질 마이크로어레이 이용법 중에서 어느 하나 이상의 방법으로 유전자 발현을 측정하는 검출시약일 수 있으나, 이에 제한되는 것은 아니다.
본 발명은 당해 분야에서 공지된 다양한 핵산 및/또는 단백질에 대한 정량 및/또는 정성 분석 방법을 사용하여 해당 유전자의 발현을 측정한다. 일례로, RNA 수준에서의 검출, 발현량 또는 패턴의 검출을 위해 역전사 중합효소연쇄반응(RT-PCR)/중합효소연쇄반응, 경쟁적 RT-PCR, 실시간 RT-PCR, Nuclease 보호 분석(NPA) 예를 들면 RNase, S1 nuclease 분석, in situ 교잡법, DNA 마이크로 어레이 또는 칩 또는 노던블랏 등을 이용한 방식이 사용될 수 있으며, 이러한 분석법은 공지된 것이며, 또한 시중의 키트를 사용하여 수행될 수 있으며, 당업자라면 본원의 실시를 위해 적절한 것을 선택할 수 있다.
본 발명은 상기 본 발명의 유전자들을 검출할 수 있는 물질을 포함하는 방광암 진단 또는 예후 예측용 키트(또는 시스템)를 제공한다. 본 발명에 따른 키트는 당해 분야에서 공지된 다양한 키트를 사용할 수 있는데, 일례로 마이크로 어레이, 유전자 증폭 키트, 면역분석(immunoassay)용 키트, 루미넥스 분석 키트, 단백질 마이크로어레이 키트 및 ELISA 키트 중에서 선택된 어느 하나 이상일 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 다른 양태로서, 본 발명은 대상체로부터 얻은 시료로부터 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자의 발현 수준을 측정하는 단계; 상기 측정된 유전자들의 발현 수준을 이용하여 진행 위험도(progression risk score)를 계산하는 단계; 및 상기 진행 위험도를 이용하여 대상체의 방광암 진행 정도를 확인하는 단계를 포함하는 방광암 진단 및 예후 예측을 위한 정보제공방법을 제공한다.
상기 시료란 바이오마커 검출이 가능한 하나 이상의 성분을 포함하는 물질 또는 물질의 혼합물을 일컫는 것으로, 생물체, 특히 인간 유래의 세포, 조직 또는 체액, 예를 들면 전혈, 뇨, 혈장, 및 혈청을 포함하나 이로 제한하는 것은 아니다. 또한 생물체에서 직접적으로 유래된 것은 물론 인비트로(in vitro)에서 배양된 세포 또는 조직을 포함한다. 본원에 따른 방광암 바이오마커의 검출을 위해 다양한 시료가 사용될 수 있으나, 이로 제한하는 것은 아니다. 일 구현예에서는 뇨, 전혈, 혈청 및/또는 혈장이 사용될 수 있다. 다른 구현예에서는 방광암이 발생한 또는 발생이 의심되는 또는 발생가능성이 있는 생물체에서 수득한 간조직/세포 또는 인비트로 세포 배양물이 사용될 수 있으나, 이에 제한하는 것은 아니다. 또한 상기 혈액, 세포 또는 조직의 분획 또는 유도물을 포함하는 것이다. 세포 또는 조직을 이용하는 경우, 세포 자체 또는 세포 또는 조직의 융해물이 사용될 수 있다.
본 발명에 따른 상기 방광암 진단 또는 예후 예측 방법에서의 유전자의 발현 수준 측정은 상술한 바와 같은 공지된 다양한 핵산 및/또는 단백질에 대한 정량 및/또는 정성 측정 방법을 사용할 수 있다.
대조군과 시료를 이용한 시험군 사이의 마커 프로파일의 비교에는 당해 분야에서 공지된 다양한 방법이 사용될 수 있다. 예를 들면 발현 프로파일의 디지털 영상 비교, 발현 데이터에 대한 DB를 이용한 비교를 참조할 수 있다. 본원에 따른 마커 검출을 통하여 수득된 프로파일은 공지의 데이터 분석방법을 이용하여 처리될 수 있다. 일례로 nearest neighbor classifier, partial-least squares, SVM, AdaBoost 및 clustering-based classification 방법이 사용될 수 있다. 또한 본 발명에 따른 방광암 진단 및 예후 추정 방법의 유의성을 확인하기 위하여, 다양한 통계처리 방법이 사용될 수 있다. 통계적 처리 방법으로 일 구현예에서는 logic regression 방법이 사용될 수 있다. 또한, 통계처리를 통해 방광암으로 진단하기 위해 시험물질과 대조군간의 유의한 차이에 관한 신뢰수준을 결정할 수 있다. 통계 처리에 사용되는 원 데이터는 각 마커에 대하여 이중, 삼중 또는 다중으로 분석된 값이다. 이러한 통계적 분석 방법은 바이오마커는 물론, 임상 및 유전적 데이터의 통계적 처리를 통하여 임상 적으로 유의한 판단을 하는데 매우 유용하다.
본 발명에 따른 방광암 진단 및 예후 추정 방법은 방광암의 심각성 정도를 판단하는데 사용될 수 있다. 예를 들면 양성대조군 및 음성대조군의 프로파일과 비교하여, 경증 , 중간정도 또는 중증으로 평가될 수 있다. 나아가 일정한 방광암 집단에 대한 마커 프로파일 분석을 수행하여, 프로파일 결과를 근거로 일정 기준에 따라 분류할 수 있다.
또한, 본 발명은 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 또는 S100A8 유전자가 발현되는 세포 또는 실험동물에 대상물질을 처리하는 단계; 상기 유전자들의 발현 수준을 측정하는 단계; 및 상기 측정된 유전자들의 발현 수준을 이용하여 상기 진행 위험도(progression risk score)를 계산하는 단계를 포함하는 방광암 치료제의 스크리닝 방법을 제공한다.
상기 시험 대상물질은 본원에 따른 마커 유전자의 발현을 조절할 것으로 기대되는 물질로, 예를 들면 약물의 스크리닝 목적을 위해서는 화합물은 저분자량의 치료효과를 갖는 것이 사용될 수 있다. 예를 들면 중량이 400 Da, 600 Da 또는 800 Da과 같은 약 1000 Da 내외의 화합물이 사용될 수 있으나, 이에 제한되는 것은 아니다. 목적에 따라 이러한 화합물은 화합물 라이브러리의 일부를 구성할 수 있으며, 라이브러리를 구성하는 화합물의 숫자도 수십개부터 수백만개까지 다양하다. 이러한 화합물 라이브러리는 펩타이드, 펩토이드 및 기타 환형 또는 선형의 올리고머성 화합물, 및 주형을 기본으로 하는 저분자 화합물, 예컨대 벤조디아제핀, 하이단토인, 바이아릴, 카보사이클 및 폴리사이클 화합물 (예컨대 나프탈렌, 페노티아진, 아크리딘, 스테로이드 등), 카보하이드레이트 및 아미노산 유도체, 디하이드로피리딘, 벤즈하이드릴 및 헤테로사이클 (예컨대 트리아진, 인돌, 티아졸리딘 등)을 포함하는 것일 수 있으나, 이는 단지 예시적인 것으로 이로 한정되는 것은 아니다.
이하에서는 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 다만, 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지는 않는다 할 것이다.
실험방법
1. 대상
1992년부터 2007년까지 충북대학교병원 비뇨기과에서 방광암으로 진단받고 입원하여 수술을 받은 176명의 원발성 비근육 침윤성 방광암 조직을 본 연구에 이용하였다(표 1).
실험대상의 기본적인 특성(n=176)
Parameters No. of patients ( % )
Mean ± SD age (years, range) 63.45 ± 12.72 (2489)
Median follow-up, months (IQR) 72.0 (37.0118.7)
Gender
Male 146 (83.0)
Female 30 (17.0)
Tumor size
≤3 cm 94 (53.4)
≥3 cm 82 (46.6)
Multiplicity
Single 96 (54.5)
2-7 56 (31.8)
≥ 8 24 (13.6)
Stage
Ta 42 (23.9)
T1 134 (76.1)
Grade
1 53 (30.1)
2 93 (52.8)
3 30 (17.0)
Recurrence (%) 137 (77.8)
Progression (%) 28 (15.9)
SD, standard deviation; IQR, interquartile range.
비근육침윤성 방광암의 진행과 관련된 유전자군을 선별하기 위한 마이크로 어레이 분석은 이중 103명의 조직을 이용하였다. 환자로부터 획득한 모든 조직들은 즉시 액체질소에 급속 냉동시키고 분자생물학적 검사를 시행할 때까지 －80℃에서 보관하였다. 실험은 조직 검사 전에 모든 환자에게 동의를 구하였으며, 임상시험위원회의 승인을 얻었다.
본 연구에서 표재성 재발은 표재성 방광암이 추적 기간 중 초기 병변 부위를 제외한 곳에서 병기나 분화도의 악화 없이 발생한 것으로 정의하였고, 진행은 표재성 방광암이 적절한 치료 후에도 더 높은 병기를 갖는 암으로 재발하거나 림프절 혹은 원격전이가 발생한 경우로 정의하였다.
2. 조직에서의 RNA 추출
TRIzol 시약(Life Technologies, NY)을 이용하여 조직으로부터 총(total) RNA를 분리하였다. 아가로오스겔 전기영동 및 EtBr (ethidium bromide) 염색으로 분리된 RNA의 품질과 상태를 확인한 후 자외선으로 외관검사를 수행하였다.
3. 마이크로어레이 발현 프로파일링
일루미나의 샘플 표지 방법(Illumina’s recommended sample labeling procedure)에 따라 혼성화를 위한 비오틴(biotin)-표지된 cRNA를 준비하였다. 즉, cDNA 합성을 위해 500 ng의 총 RNA를 사용하고, Illumina® TotalPrep RNA Amplification kit (Ambion Inc., Austin, TX)를 이용하여, 연결된 증폭/표지 스텝(coupled amplification/ labeling step) (in vitro transcription)을 거쳐 비오틴 표지된 cRNA를 합성하였다. cRNA 농도는 RiboGreen (Quant-iT™ RiboGreen® RNA assay kit; Invitrogen-Molecular Probes, ON, Canada) 및 Victor3 분광광도계(PerkinElmer, CT)를 사용하여 측정하였다. cRNA 품질은 1% 아가로오스겔 전기영동을 이용하여 검증하였다. 제조사(Illumina, Inc., San Diego, CA)의 지시에 따라, 표지된 증폭물질(amplified material) (어레이 당 1,500 ng)을 Illumina Human-6 BeadChip (48K), version 2에 혼성화시켰다. 어레이 신호는 Amersham fluorolink streptavidin-Cy3 (GE Healthcare Bio-Sciences, Little Chalfont, UK)를 사용하여 BeadChip 매뉴얼의 지시에 따라 검출하였다. 어레이들은 Illumina Bead Array Reader confocal scanner (BeadStation 500GXDW; Illumina, Inc., San Diego, CA)를 사용하여 스캔하였다. 전체 마이크로어레이 데이터 세트는 온라인상에서 이용 가능하다(http://www.ncbi.nlm.nih.gov/geo/ under the data series accession number GSE13507).
4. 실시간 연쇄중합반응
원(original) 독립집단에 대해 Rotor Gene 3000 PCR 시스템(Corbett Research, Mortlake, Australia)을 사용한 RT-PCR을 수행하였다. 내부 대조군(internal control)으로 GAPDH를 동시에 분석하였다. 마이크로-반응 튜브(micro-reaction tubes) (Corbett Research)에서 하기 표 2에 기재된 프라이머 및 SYBR Premix EX Taq (Takara Bio Inc., Otsu, Japan)을 포함하여 Denaturation: 96℃, 2sec, Annealing: 60℃, 20sec, Extension: 72℃, 20sec의 조건에서 RT-PCR 반응을 수행하였다.
Gene Sense Anti-sense
COCH AGA AAG CAG ATG TCC TCT GC
(서열번호 9)		 TCC CCC TGA GTT GCT GAT TA
(서열번호 10)
S100A8 CAT CGA CGT CTA CCA CAA GT
(서열번호 11)		 GAA TGA GGA ACT CCT GGA AG
(서열번호 12)
CELSR3 CTC CAT GTT GGT GAC TGT CAC
(서열번호 13)		 TCC TGC CAC ATG TTC TCA AG
(서열번호 14)
PFKFB4 ACT GAA CCC CCT GAA GAA GA
(서열번호 15)		 ATG AGA GTT GGG CAG TTG GT
(서열번호 16)
HMOX1 AAC TTT CAG AAG GGC CAG GT
(서열번호 17)		 CTT GTT GCG CTC AAT CTC CT
(서열번호 18)
MTAP TCC TTG AGG GAG GAG ATT CA
(서열번호 19)		 TCC TCT GGC ACA AGA ATG AC
(서열번호 20)
MGC17624 GTC CTG AAC GAC AAG CAC CT
(서열번호 21)		 AGG CTT CTG GGT CGA TTT CT
(서열번호 22)
KIF1A AAG AAC AAG GGC AAC CTT CG
(서열번호 23)		 CTC CAT TCA TGT TGG TGG CC
(서열번호 24)
Rotor-Gene Real-Time Analysis Software 6.0 Build 14 (Corbett Research)를 사용하여 분광학적 데이터를 분석하였다. 유전자 발현은 GAPDH 발현에 대해 정규화하였다.
5. 통계 분석
103명의 원발성 비근육 침윤성방광암 환자의 방광암 조직 마이크로 어레이 유전자 발현을 unsupervised hierarchical clustering analysis 기법을 통해 분석하였다. 비근육침윤성 방광암의 진행과 관련된 유전자군의 선별은 univariate Cox regression analysis를 통해 97개 유전자 군을 선별하였다. 이중 상위 10 percentile에 해당하는 8개 유전자군을 비근육침윤성 방광암의 진행 예측 유전자군으로 선별하였다. 하기 수학식 1에 기재된 바와 같이, Cox 회귀 분석을 통해 8개 유전자 각각에 대한 COX 회귀계수(Cox coefficient)를 구한 후 환자의 8개 유전가 발현값을 곱하여 진행 위험도 (progression risk score)는 구하였다(표 3).
[수학식 1]
Risk score = ∑ Cox coefficient of gene G i × expression value of gene G i
Progression related-gene classifier in NMIBC
Molecule Id Hazard ratio (HR) COX regression coefficients
COCH 1.19 0.173953307
CELSR3 1.246 0.21993842
HMOX1 1.251 0.223943231
KIF1A 1.06 0.058268908
MGC17624 0.67 -0.400477567
MTAP 0.906 -0.098715973
PFKB4 1.4 0.336472237
S100A8 1.176 0.162118849
상기 진행 위험도의 임상적 검증은 176명의 비근육침윤성 방광암 환자를 통해 시행하였다. 각 환자들에 대해 상기 진행 위험도를 구하여 ROC curve의 AUC를 통해 근육침윤성 방광암으로의 진행 예측도를 구하였다. Progression risk score median 값을 기준으로 high score group vs. low risk group으로 나누어 근육침윤성 방광암으로 진행되는 무진행 기간을 Kaplan-Meier 생존분석법을 이용하였다. 다변량 Cox 회귀분석을 이용하여 기존에 알려진 임상병리학적 인자를 보정한 후 progression risk score가 진행의 독립적 인자임을 조사하였다. 통계프로그램은 SPSS 20.0 (SPSS Inc, Chicago, USA)을 이용하였고, P값이 0.05 미만일 때 통계학적으로 유의한 것으로 판정하였다.
실험결과
1. 진행 위험도(Progression risk score)
마이크로어레이 유전자 발현 프로파일링(Microarray gene expression profiling)을 통해 선별된 8개의 진행관련 유전자들은 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4, S100A8이다(표 3). 진행 위험도(progression risk score)는 다음과 같이 구할 수 있다.
Progression risk score = log2(COCH expression) x 0.1739 + log2(CELSR3 expression) x 0.2199 + log2(HMOX1 expression) x 0.2239 + log2(KIF1A expression) x 0.0582+ log2(MGC17624 expression) x -0.4004 + log2(MTAP expression) x -0.0987 + log2(PFKB4 expression) x 0.3364 + log2(S100A8 expression) x 0.1621
2. RT-PCR에 의한 진행 위험도 모델의 검증
비근육침윤성 방광암 환자에서 진행 위험도(progression risk score)의 암진행 예측 정확도는 ROC 곡선에서 0.769 였다 (P < 0.001, 도 1).
Progression risk score median 값을 기준으로 high score group 과 low risk group의 무진행 생존기간을 분석하였을 때, 진행 고위험군은 저위험군에 비해 유의하게 짧은 무재발 기간을 보였다(P < 0.001, 도 2).
Cox 다변량 회귀분석에서 progression risk score는 암진행의 독립적 인자였다(표 4). 기존에 알려진 임상병리학적 진행 위험인자들 (종양 크기, 다발성 종양, 고등급 종양)을 통제하였을 때, progression risk score는 연속형 변수로서 표재성 방광암 진행을 1.453배 증가 (95% 신뢰구간, 1.2091.747) 시키는 것으로 나타났다.
Figure 112016063413176-pat00001
이상으로 본 발명 내용의 특정한 부분을 상세히 기술하였는 바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적 기술은 단지 바람직한 실시 양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항 들과 그것들의 등가물에 의하여 정의된다고 할 것이다.
SEQUENCE LISTING <110> THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION <120> Biomarkers for diagnosis and prognosis of bladder cancer and uses thereof <130> PN1605-164 <160> 24 <170> PatentIn version 3.2 <210> 1 <211> 16123 <212> DNA <213> Homo sapiens <400> 1 cccccgcaca gtgctcatgc gcacggccca gcctttatag cggccgcggg ggccttgcct 60 tccgcactcg ggcgcagccg ggtggatctc gagcaggtgc ggagccccgg gcggcgggcg 120 cgggtgcgag ggatccctga cgcctctgtc cctgtttctt tgtcgctccc agcctgtctg 180 tcgtcgtttt ggcgcccccg cctccccgcg gtgcggggtt gcacaccgat cctgggcttc 240 gctcgatttg ccgccgaggc gcctcccaga cctagagggg cgctggcctg gagcagcggg 300 tcgtctgtgt cctctctcct ctgcgccgcg cccggggatc cgaagggtgc ggggctctga 360 ggaggtgacg cgcggggcct cccgcaccct ggccttgccc gcattctccc tctctcccag 420 gtgtgagcag cctatcagtc accatgtccg cagcctggat cccggctctc ggcctcggtg 480 ggtgcgcgcc cctcacgacc ccggcccctt gctccgctgg gtggaggctg gagccagccc 540 tcacgcttct ctcttcgcag gtgtgtgtct gctgctgctg ccggggcccg cgggcagcga 600 gggagccggt gagtggggga gctggggtgc gtccaggcgg tcgcaggggc tgagcaccag 660 cgggtacaag cgggactcag atccagcccc ttgggcttca gccctaccgc ctgaggagga 720 aggcgcgaag gttgagccgc cgcgtggcgc gcccgcgtta acccctgcag ccgatctgct 780 cctgctcacc tgtttctccc atggtagggg gcccctgggg tccagtgggg ggacgttctc 840 caagagcact aggaagaagg cctcctccag gcccacccac agccccagac cccgggcccg 900 ctgagcgccg gcagcaggag gtcgaggaag gaggactcct tgagcctcac cgaggagcgc 960 accagtcctg ggctctgctg cgtttggggg tggaggagaa gccgcccaga cccgacttca 1020 ggttgccgta gccgagagag agggaggcga acgtcgctgt cccaccttgt ttgactcgct 1080 agctatgttt ctaggtgtaa cccctataat cagaagcact cgcggtctca ctctacacgc 1140 tagagagttt aaaaagtttg taccacgtgt agaggtccgg gtatgggtgt gtggtttggt 1200 gtattttcca gtgtaaaagg caacgctttc ctaagagcta ccgtttgttt tccttgaaag 1260 taggaatgag ggttaagtat ccctcatggc tgtatttctc ccgctctact taacaaaagt 1320 cagtgttcgc aactaaaggc ggtcggtctt ggcaccggat tccgatgccg cccccatctc 1380 agcggaaaat gggaggaagg attaaggctg tttgatgata ggtatgaggc tgtttagggg 1440 taaggatttt aacctctcag ctctctagac tgcttcagag ctaagaaatg ggcattgcgc 1500 ctgcatcctt ccttctcttc catggaatgt aaggtacctg tcaccacaaa gggcacagag 1560 gagggtgctt gtcacaggca aggtactcag ttggacagta tggccagaaa gtattcctct 1620 gccttggaaa aaaaaggttt ttaaaattaa tatatgtttt aaaaaggttt ggataactac 1680 aacttcccat gtttgaaaaa tagcatttaa taacattaat ctcaatttag tatcgacagt 1740 aaattcacaa attaacatgt tgtattatgt tatcttgtta cttgttgcca agagcttgtc 1800 tcttcctagc atcatttata gtaaaaactg attctttgtt aggttgacag tgtaaaactt 1860 gagaatatta acagtgcttt ctaaaaatgc atccgctgct tgataaatct cactggacag 1920 atctggagca gaaataatca ggttcaatta agataaaaat gctgtattct gaagggattc 1980 acttttctgt tttctgtcct tcgggagttg tagaatgttg tttgggcaaa ttaaccccac 2040 ggctttaatt ttctcatcta taaaatgaac aatcaagtta gataactttc tgtgaatcta 2100 agcatctttt tgttggcttc cttaatgtgt gagtttaagg atctgcattt gtaggctaac 2160 taggataaat ggtcctatga aggaaaggat ggctttgatt tgtgcacatg tctatgaaaa 2220 tgttccacaa aggctcaatc cagatttact atctttacct caagcaactg tgtacatagc 2280 gtcatcaaag ttgagattta aaaatttttt tttttcttct ggagacaaga tcttattctg 2340 taacccagga tggagtgcag tgatgcaatc atagctcatt gcaagcttga actcccgggc 2400 tcaagcaatc ctcccacctc agcctctcca gtggcggaga gtacaggcat gcaccaccac 2460 gtgtggccat ttaaaaaaaa tttttttttt ttagaagaga tgaggtcttg ctatgttgtc 2520 cagactggtc ttgacctcct ggactcaagc aaatcctctt gtcttggcct gctaaagtgc 2580 tgggattata ggcatgagtc accacgccca gccaagattt tttatatttc tataattaat 2640 attaaatgac ttttattttc tagttcagat atagttccaa ttatgtattt ccaacctggt 2700 taagaactga gaagccaggc acagtggcac acctgtaatc ccagctacta gggagttgga 2760 ggtggatcac ttgagctcgg gaatttgagc ctagcttggg caacttggcg agtccccatt 2820 tcaaaaacaa aaacgaaata aaaacccaga actttcacat tagagtttta tagtggctgg 2880 ggactatatt aaattggaaa acaaccttgt ggcttgccaa aatctggaat ggtatggaag 2940 ggtatataag tcaatagtca taactagaag tgtagaaatt agggaagtaa aacttaaatc 3000 tcacactgta gtctccccac cactatgccc caagaagtcc taagaatgct tacaatatta 3060 tctccttttt cttcagctcc cattgctatc acatgtttta ccagaggctt ggacatcagg 3120 aaagagaaag cagatgtcct ctgcccaggg ggctgccctc ttgaggaatt ctctgtgtat 3180 gggaacatag tatatgcttc tgtatcgagc atatgtgggg ctgctgtcca caggtaagcc 3240 caaacacacc agggtgggag agaaatgcag acgtgattat ttcctttcct gctttaccca 3300 tctggatccc tttcctccct gcattctttc ttttgttgcc attgtggcca cagaaaatgg 3360 atatattttc acggttctcc tggatatact tgaaacacca aatacacatg gaaagctttc 3420 tgacaaaagg caaatagcat tacctcttga tggctagatt gctatgattc caaaacattc 3480 ctaatcatgt gatatattac tgagttatta ctatgtgcca cctattgttt taacttccac 3540 cacaactcta caaggtaggt agaattttac tccagttaca gatgaagaaa ctgaactcag 3600 agagttgtca agtatcttgc ccaaggtgac tattgttagc aagtgccatg ctatcctgta 3660 gtagaatagc cagtataata cttctaaaaa aattcagtcc aaaggcatgt agctaaagtg 3720 agtatcttag gaaaattgtt tggtgctctg aatttctaag ttgtgggtaa tgggatatta 3780 caaatgtgtt cttatcaaca cttaagaagt tcaacagcac aaaaccattt ttttccaggc 3840 aaattttgtt cttgtgtaag caagttttta aaaggctagc agcagctggg agtggtggct 3900 cacacctgta atcccaccac tttgggaggc tgaggcggat ggaccacttg aggtcaggag 3960 ttcgagacct agccaacatg gtgaaaccct gtctctacta aaaatacaaa aattagccag 4020 gtatggtggt gcatgcctgt aatcccagct acttgggagg ctgaggcagg agaatcactt 4080 gaatcctgga ggtggaggtt gcagtgagcc gagatcgcgc cactgcactc catcctgggc 4140 tacagagcga gacgccatca aataaataaa taaataaagc agaatcttta gatgacttcc 4200 ctgatgagct attttcttga ttaatcaaag caatagatac aacatggcac tataagtcag 4260 tgggatgccc tgaaaaagtg tggatagcat ctcagctgct attcttgtgt tacaggggag 4320 taatcagcaa ctcaggggga cctgtacgag tctatagcct acctggtcga gaaaactatt 4380 cctcagtaga tgccaatggc atccagtctc aaatgctttc tagatggtct gcttctttca 4440 cagtaactag taggtataat tattgttctc attctgtaat attctcccac cccccaaacg 4500 ttttctgctt tttttagctc agcctcttta accttgatgg aaaaacctgt gatcaagact 4560 aaagctgacc tatagaggta aactgtaggt tagactgagg ggtcaagtac ccactgaagc 4620 caaatttggg tgaatagaag acaatcttac tgacagatga tggcaataga aacttgaatt 4680 atttgcagtc agaatgcccg gacacttacc aaggaactga aaaactacta aatacatttt 4740 tgatgatcct ttgaagatat aatggataag cattttggtt ctctgaaact agcatgcagc 4800 aggatgtttg taactacaat caccattacc ctattacatt tgtcattgta gagagctcta 4860 aattagattc ataatacttt ggtaaagaag gaaaaggaaa aaaataagct tatttttatt 4920 ttaacagaag gcaaaagtag tacacaggag gccacaggac aagcagtgtc cacagcacat 4980 ccaccaacag gtatgaacta tgaaacctat ctcctagttg cccggcacag catttggaag 5040 ttatgaataa acgtgttgtt ggtagaagct tttcttaaag aaatttgata ttaaagagaa 5100 acaaagcaaa taccttaagt ttactggtat attacatatg gaaacattca ttatgtgtat 5160 attttaaaga cagggtctca ctctgttgct caggctggag tacagtggtg caatcatagc 5220 tcactgcagc cttaacctcc taggctcaag caatcttctc accttggcct cctgagtagg 5280 tggtactaca ggcacatgcc accacaccca gccaattttt ttgattttta atttttttta 5340 tttttatttt tttagacagg tctagctatg atgcccaggc tggttttgaa ctcctgacct 5400 caggcagtcc tcccacttca gcctcccaaa gttcagggat tacaggcatg agccactgca 5460 cccagcctaa taattctcta aaagtcctat tttctcccag atttgataaa ccacgcctaa 5520 gaactggtca aagtaccatg aacttctagt tccatttgct tcattaaatt cctttaatta 5580 ctgcactgtc atgtgactaa aaggaatgtg tgtctattgt aagaaatagc cagggatccc 5640 cttttgtatg acgatggcag ttttaaagtc aaagatatta agaacattag gatttaatgt 5700 tgagttcctg cctcacctgt gggtttgggg tattaaagtc ctggattagg gcatatcaaa 5760 tatgtaggcc tacatactga tttgtttatt tgttgggtca ttgctttccc tagtccagaa 5820 aatcctgagg aaattaattt ttttaaaaaa gtcctttcaa gaatggcact ctgttgttat 5880 gagcttctcc ccatgtgggt ttcttgctat gtaactgtct tccttttgtt aatgccaagt 5940 gcatctttta tttcaggtaa acgactaaag aaaacacccg agaagaaaac tggcaataaa 6000 ggtaagaatc aagatctcca tttgggaagg tagcattttc cctccctcct cttgagactg 6060 ctaatgaggg gactggtttg gttgttcgca gattgtaaag cagacattgc atttctgatt 6120 gatggaagct ttaatattgg gcagcgccga tttaatttac agaagaattt tgttggaaaa 6180 gtggctctaa tgttgggaat tggaacagaa ggaccacatg tgggccttgt tcaagccagg 6240 taccaacctt gttaaaatgg gagatttaaa aaaaaaatta ttttgtaatt gacacataat 6300 aattatatat acttatgggg tacatagtga tgttttcata catacaatgt atagtggtca 6360 aatcagagta attagcatat ccatcacctc aaacattgat catttctttg tgttggatac 6420 attcaaaatc aaatgaggcc gggtgcagtg gctcacgcct gtaattccag cactttggag 6480 gccaagtggg tgtgtggatc acctgaggtc aggagttcaa aaccagtctg gccaacatgt 6540 gaaacaccgt ctctactaaa aatacaaaaa ttagccagat gtggtggcat gcacctgtaa 6600 tcctagctac ttgggaggct gaggcaggag aatcacttgg actcgggagg cagaggttac 6660 aatgagccga gattgcacca ctgcactcca gcctgggcaa cagtgagact atgtctcaaa 6720 aaaaaaaaaa aaaaagaaaa aaatcaaatg agaggagatt tgaatgagtc ttgaatgatg 6780 acaaatgatc agttctttta gtgggtacat gtcagttcag tataaacatt tgagttatgg 6840 acacactggg ttcccaaact gtaagttcag gatctaagac tgcctgggca gactgagtag 6900 atctgagtgc ctcctttttg gaataaaaga atttagaaaa ctgtgtgcta tctatataag 6960 aaccagaagg tagactggag agtcctgttg cttacacaag tcacctctgc ttatctactc 7020 tgctcaattc ctaatttctc tcttctgaag gaagaagcag tgatatgtct attccacctc 7080 cctattctgt tattcttttt agctctttcc atattctctt ggttggtgat ctgaagcacg 7140 acctttctat tttattcatt taaaaatatt tattaattgc tggccaggtg cggtggctca 7200 cgcctgtaat cccagcactt tgggaggccg aggcggatgg atcacggggt caggagattg 7260 agaccatcct ggctaacacg gggaaacccc gtctctacta aaaatacaaa aaaaaaaaat 7320 tagccgggcg tggtggcagg cgcctgtagt cccagctact cgggaggctg aggcaggaga 7380 atggcgtgaa cccaggaggt ggagcttgca gtgagccaag atcgtgccac tgcactccag 7440 cctgggcaac agagcaagac tctgtttcaa aaaataaaaa taaaaataaa taaataaata 7500 aatatttatt tattaattgc ttttagaaat agaatatgct cattatagaa agcttgaaaa 7560 tacatagagc acaaaaaaag aaatgctcta aatcatatgc cctagagata atcactataa 7620 aatggttttt tttttttttt tttttttttt ttgagacgga gttttgctct gtcaccgagg 7680 ctggaatgca atggcacgat ctttgttcac tacaacctct gcctcctgga tttaagtgat 7740 tctcctgcct cagcctcctg agtagctggg atcacaggtg tgcactacta cgcctggcta 7800 atttttgtat ttttagtaga gacaaggttt caccatgttg gccagcctgg tctcgagctc 7860 ctgacctcag gtgatccacc tgcctcggac tcccaaagtg ctaggattac aggtgtgagc 7920 taccacgcct ggccccttca gtattttaag gaaatatttg actgtattat tttttaaaaa 7980 ctcagactat taaaaatgcc ctgcatcctg tttttttcat cctttagtat ttttagcatt 8040 ttctcatatc acaaatattc atcaaaaata tttcataata ttccgctgca tgattagtca 8100 ttcttattat ttcttcacta cattacacac tacactgtga tgaacatcct tatatcatct 8160 ttgtgcccat ctctgattat ttcatcaggt tagatttcta aaagtgaggt tctgacttaa 8220 agcctctgat ataaatagtg aaattgagcc atgcacagtg gctcatgcct gtagtgccag 8280 ctgctcagga ggctgaggtg tgaggatctc tcaagcccag gagttcaaag ctgcagtgag 8340 ctatgatggc accactctac tccagcctgg acaacagaga aagaccccat ctctaaaaaa 8400 acaaataaat agcgaaattg cttcctagaa aggtgaagta gtttaaacta ctatcagcag 8460 tgtgtaaggt tgtataaaca gtgctattac aaatattaat ttccatttca tttctgttat 8520 tttttacaag tggctctgct cttagattag atagaatttt tttggcatga gaagaaaatt 8580 taactgtttt aacataattt aaccatttgt ctctcaccct taaaaaaaat gtgttccttg 8640 tttcattgac ttatggtatc acatttatac ctgagtttga gcaagtctat ttctttgatt 8700 catatgctaa tccttacata tttttttcta cgctgctttg attatcacag ttttattgca 8760 cattttaaca tcccatgagg caaattcccc tgcagtactt tttgtcttgt acttttttct 8820 gactactttg acccaattct ttttgaagat gaattcttca ttaccttgta gactcataca 8880 aagttttgta gtttttctgt tttagaaaga ccattagaat aggtaaacca tgtcaagttt 8940 atatgtatgt aagtcaaaga acagaatata tcaaggatac aaaaatgaga ctaatttcat 9000 aagtcataat ctggatagtt gaaaagtgac cacaagtgaa aaggttttca acccatgaaa 9060 tctgatttta tgacccaata ttccatcagg tatgtatgca gaaatacagt cagtgttcta 9120 cttctccctc aaaaaatctt gaataaaatg gctactgata atgctaagat cttaaatttt 9180 gcactaggaa atactgactc atctagaaac taaacacaac agattgtgct gtggttgttt 9240 atactcaaaa cggtctctgc tgaacacaga gtagttatat aaaagtgagc tgaaattcct 9300 ttaatattaa atataggaaa tgagatctca aaactcttac aatacacata attttaaggt 9360 gcacaaatgt cattgtcatt ataagaaaaa ctcaatattg taactttata attcatttca 9420 cctttgtccc tttaaaaaaa tgttgacggt cacatcaatg aaattgtttc tcctgaacag 9480 agagctctga gttaatagat ccacactact tagagcctct ggggtcccac actggaacag 9540 accctagtct catacccagc cacttcctca tttagtttag ctacctggtg cccaactctg 9600 cggacttctg ttaaacccga ggctctgagc caagcccgat ttcaagttct ccgtatagtt 9660 taggcatgga ctttgcagcc agacaacttg aacttaaaat gcagctgtgt ttcatcaggc 9720 aaactcccta aatgctctga gactcagttt cttcatttac ataattggga taattccaac 9780 cttatagagc tatgatgaaa tgaggtttta catgtgttat gcttttggct tattacccag 9840 aatataataa atcctcaata tggcaattat ttgttacacc tctgaaatat ctccaataat 9900 tcaagtaagg atgcaatgcc tcagttgact atgtactatg gaattaagaa agaaacttgt 9960 gtgttgtctg gttttaaaac tgttttttaa ggcatgtaat gttgcttatt ttaccttttt 10020 aattctccct gaataacatt ttctttcttc cactcagtga acatcccaaa atagaatttt 10080 acttgaaaaa ctttacatca gccaaagatg ttttgtttgc cataaaggaa gtaggtttca 10140 gagggggtaa ttccaataca ggtaagtaga ctttgatacc tgggatgtaa cataggagag 10200 ggttatcagt gatcagacat gtaaaacagt attatgctat tttatatgag cagatgtgaa 10260 atcctcctgg aactgaaatc ttggctaggt ctgcatttga tcatctgaga taaattttca 10320 atttataatg gaagtatacc aaagtgttga tatttcttat tttaaaaaat ataaagcatg 10380 gtgatttaga attctcatac attggattga ctagatataa cattggagaa gtatctcttt 10440 gtaatgctaa aaagaagtga aaatcaacag acttatctaa tgaatgcaga tgtggcagaa 10500 agaatgagta gcactaccgt tgactctgaa gagagacttc ttagaggtac taatcagtca 10560 ccaaagggct acatagagag cacatgcatg gaagtgggaa tcagttttgt gtttctaact 10620 ggcgattgat gtggggtaaa caaatgtgag gcttctagga ggtggagggg gaactaatat 10680 ggcttgtgaa gataaatagg cctggtagat aattaaactt tcccagctga tgcatctgtt 10740 acagaactgg gttctatata attctttttt gtgtgccccg ccccactgcc agttctatat 10800 ataattctta aactttgcag catcaaatgc tacagggaaa cagaaatgtg gtttgagcag 10860 tggtaaaggc tatttgtttg cttctttttc aaatttagga aaagccttga agcatactgc 10920 tcagaaattc ttcacggtag atgctggagt aagaaaaggg atccccaaag tggtggtggt 10980 atttattgat ggttggcctt ctgatgacat cgaggaagca ggcattgtgg ccagagagtt 11040 tggtgtcaat gtatttatag tttctgtggc caagcctatc cctgaagaac tggggatggt 11100 tcaggatgtc acatttgttg acaaggtaaa gtggtgaggg ttatcttctg ttacagtgat 11160 gggtattcca ttttggacct ctaagtgcag tgctgactgc ctcttatcta gattaacttg 11220 aaacattcag gattttccag tttttaagaa gaaacaactt ttgatccttt tggatatctt 11280 ttatgtgtct cccccattag gctgtctgtc ggaataatgg cttcttctct taccacatgc 11340 ccaactggtt tggcaccaca aaatacgtaa agcctctggt acagaagctg tgcactcatg 11400 aacaaatgat gtgcagcaag acctgttata actcagtgaa cattgccttt ctaattgatg 11460 gctccagcag tgttggagat agcaatttcc gcctcatgct tgaatttgtt tccaacatag 11520 ccaagacttt tgaaatctcg gacattggtg ccaagatagc tgctgtacag tttacttatg 11580 atcagcgcac ggagttcagt ttcactgact atagcaccaa agagaatgtc ctagctgtca 11640 tcagaaacat ccgctatatg agtggtggaa cagctactgg tgatgccatt tccttcactg 11700 ttagaaatgt gtttggccct ataagggaga gccccaacaa gaacttccta gtaattgtca 11760 cagatgggca gtcctatgat gatgtccaag gccctgcagc tgctgcacat gatgcaggta 11820 aggtccttgt tctttatagg agaagggaac agaaaaaacg gttcagtgaa tttaggagta 11880 aataaaaatt taagcattta tttcattaaa caaacacctg tggctttacc caatattaac 11940 tgttaaagca gccctactca tctcattcta cagataagga agcaaacttc ctggaaatga 12000 catttctagt aagtggcaag gccaagatcc aaacccaggc attctggctc cagagtgcac 12060 attcctaacc actgtattgt tgggagaatt gccatgagaa ccatgtcaca ttaaggaaat 12120 atgcttatac atatacaatt aaggtgctca tatttagctc aaacttggac tatatctcca 12180 aatagccagc ttataaccta ccatgaatct gccattcagt aatttatcct aactttcttg 12240 tgtatgaaac aggtaattgc tctgtcacca ggctggagtg cagtggcatg tagtgagcta 12300 caacctccaa ctattgggct caagcaatcc tcctgtgtca gccttccaaa tagctaggac 12360 gacaggcaca tgccactgcc cctggctaat ttttaaattt ttttggggag agacgggggt 12420 ctcactttgt tgcccaggct gatctcaaac tcctgggctc aagcaatcct cacaccttgg 12480 cctcccaaag tgctgggatt acaggcataa gccaccacac ccaaccctaa cttttatttt 12540 agtcaagttt tgtctggcat gagtttccta agataaggtc tcccatagac tttacctatc 12600 ccatcaaaat ttccttggcc aggtgcagtg gctcacatct gtaattcagc actttgggag 12660 gctgaggtgg gcgggatcac ctgaggtcag gagttcaaga ccagccgggc caacatggta 12720 aaacccagtc tctattaaaa atacaaaaat tagctgggtg tggtaacata cacctgtaat 12780 cccagctact caggaggctg aggcacgaga atcacttgaa cccaggaggc agaggttgca 12840 atgaactgag atcgtgccat tgtactccag cctgggcgac agagtgagac tctgtctcaa 12900 aaagaaaaaa aaaaaaaaaa aaaaactttt tcccccccgc ttaagataat aaaaacacac 12960 tctggtgtta taaaagggta taagaagggt ttctttcttc ctcaccccag ccttaatatt 13020 acttttggca caggcctcgt tcctgaagac attaacgtaa tgtgttagag atcaaatagg 13080 ccaacaaaaa gctaagattc cctttctgag gatataactg agtgacagga gggaagaatc 13140 aatggacttg ttttttttaa cactcttctg tacctcattt tccctactta attcctaatg 13200 acataacctt tttcctttct acacattagt acctctgcca atgtactcac atatttttac 13260 agatactgat gaaagattat tcttaaaaca gagaacacat gcaatttaag ttccacatct 13320 agcttgtaaa aagtattttt tatacatcag caactagcct gtgaagtaaa gacctgttta 13380 ctatcatatt ccttaatact tagcttactg aacttatagt taacaggatt gtattcaggc 13440 tataaagtga ttaggttgat taaagttcag gaggctggac tacaccaata ttgattcgtg 13500 aaaattatcc cttagtgata ttgaaagttg caaaagccag aaaatagggt aggattttag 13560 gggtagatca caacagtttt tatttatttt cagggtcttg ctctgtcacc caggctggag 13620 tacagtggtg tgattatttt tttttttaac tgtaattata tgctgggctt gagctaaaca 13680 atctgaacta gaatgtagaa ctgaaaagaa gtgaggaaaa ctgaggggga ggaaaaaaat 13740 attttgactt tttttttttt taaccaggga gtgagagtca ggaaaaggag actggaacaa 13800 ttggacattg ttccaagtag cttttacatc atctaaacct gctgcatatc ttaggtattt 13860 accactctga gcactgtata ccactagaag gggaatgaaa ccttagatct gtagaggaaa 13920 actattacag aaactccaaa agttatagaa aattgcaccc agcattagat agatggtact 13980 ctacactaag aatctgctaa atgaggccag gtgtggtggc ttatgcctgt aatcccagca 14040 ctttgggagg ccgaggcaga tggatcgctt gagccctgga gttcgagatg agaccagcct 14100 gaacaacatg gtgaaacccc atctctacaa agaaatttaa aaattagctg ggcttagtgg 14160 catgcgcttg tagtcccagc tatttgagga tgggggtgct gaggaggata gtttgagccc 14220 aggaagttga ggctgcagtg agccttgatt gtaccactgc actccagcat gggcaaaaga 14280 gccagaccct gtctgagaaa aaaaaaaaaa aaagattaaa tgaaaacttc tacaattggg 14340 attggggtga atccaactaa tgtattatta ccctaaatgt acagttgtac taaaagcctt 14400 ctagtaacta aagtgaatgg aaatagaata cctcaatgaa actggaagaa attactccag 14460 tttcataaga tccctcttgg gcagtacttt ttagtcacta gttttgcttt gggattatag 14520 gctgacattt tctgattatt agacagtttg ccaatataaa gattgaaatg gaagaggatt 14580 tttcattatc agaggactag tcaccattcc tcaaacaatg caacctttga acacttttgc 14640 tatttactta tcccatctct tgtgccattc ttccttgctt taatggattg tgactctgac 14700 tccagtatac tgtttgatgc aggccaacct catacggaaa attttcacca tccgcattta 14760 ctgtaggatt ttaaaaaaga tactgtggat caggttaaaa gtcttcttct attcctagtt 14820 tataggtgtg ttctgtcatt aatggatatt gaactttatc aaattatttc ttatcagtga 14880 tgacttacct gttaatgtgg cgaattacag atatagcaga gtttctggtt tggaccactc 14940 ttttgccact ctcgtcacaa tgactgtgaa aacttaattt gttcagggga tttaattgtc 15000 cagaaattag taagcagttt tcgctgcaac tatgtaacag tgtatggaaa acatatagac 15060 ataattccat atattagcta gacctgattt tcaattcact ttaaaatgtt ttcattgtag 15120 gaatcactat cttctctgtt ggtgtggctt gggcacctct ggatgacctg aaagatatgg 15180 cttctaaacc gaaggagtct catgctttct tcacaagaga gttcacagga ttagaaccaa 15240 ttgtttctga tgtcatcaga ggcatttgta gagatttctt agaatcccag caataatggt 15300 aacattttga caactgaaag aaaaagtaca aggggatcca gtgtgtaaat tgtattctca 15360 taatactgaa atgctttagc atactagaat cagatacaaa actattaagt atgtcaacag 15420 ccatttaggc aaataagcac tcctttaaag ccgctgcctt ctggttacaa tttacagtgt 15480 actttgttaa aaacactgct gaggcttcat aatcatggct cttagaaact caggaaagag 15540 gagataatgt ggattaaaac cttaagagtt ctaaccatgc ctactaaatg tacagatatg 15600 caaattccat agctcaataa aagaatctga tacttagacc aaaagcaaca ttcgttctct 15660 aaccattctg tattgattat ataagcaaaa tgaaaagaga aacttaaatg aacacagctc 15720 tttaacatgg ttcaggtaca catattttga cccaagtgga tattttctta aaaccaatca 15780 ataatagcta gctattactg cagactataa aatctggata tagaaaggag acctgtatca 15840 aactgctttt gtagtgtgtt ttcataacaa cttatgacta aaaatatcac actgaataag 15900 agagcaggat tgccaggtat ttttctattt ctctccttaa ttttatatgt atatagatat 15960 atttggctta tattctaagt cacctaagta cttaaaagtt aagttggtaa agtatttact 16020 gactgcttat aaacatttaa agacaaagac atttcaaata actgcagaaa aaatattgta 16080 gtttgaatat ttaagcaata aaactgctag tgagttattg taa 16123 <210> 2 <211> 11974 <212> DNA <213> Homo sapiens <400> 2 agcgaaccat cggggcggcc gggagccatg ttggagcggc gggaggcggc agcagcgtcg 60 gggatgctgt ggtgggggcg gaaaaagcca gggccgcacg ccggaggggc tccggccgcg 120 gagtagatgg tgcccagagg gcggcggggg tgcggagaga caggcggagg ggcgggggcc 180 cggggcggcg gcaggggccc gggagggggc ccgagcggcg gggccagccc aaggcccgga 240 ccggggcggg gggcggtgga ggccgtgcag ggaggcgggg gatgatggcg aggcggccgc 300 cgtggcgggg cctcggggga cggtcgaccc ccatactcct gctccttctc ctctctttgt 360 tccccctcag ccaggaggag ctggggggcg gtgggcacca gggctgggac ccaggcttag 420 ctgccactac ggggccaagg gcgcatatcg gtggcggagc cttagctctt tgtccggagt 480 cttccggggt ccgggaggat ggggggcctg gcctgggggt cagggagcct atcttcgtgg 540 ggctccgagg gagaaggcaa agcgcccgga atagtcgagg gccccctgag cagccgaatg 600 aggagctggg gattgaacac ggcgtccagc cattgggcag ccgcgaacga gagacaggac 660 agggaccagg gtctgtgtta tactggcgcc cagaggtctc ctcttgcggg cggacaggac 720 ctttgcaaag aggtagtctg tcaccagggg ctctgtcctc aggggtcccg ggctcgggga 780 acagctcgcc cctcccttca gactttttga ttcggcacca cggtcccaag ccggtgtcct 840 cccagcggaa cgctgggaca ggctcccgca aaagagtggg caccgcgcgc tgctgtgggg 900 aattatgggc aacagggagc aagggtcagg gcgagagagc cacgacatcc ggagcagaaa 960 ggacagcccc ccggcggaac tgtcttccag gggcctcggg atctggcccc gagctggatt 1020 cagcaccacg cacggcgagg acagctcctg catcaggttc agcaccccgc gagtctcgga 1080 cagctcccga gccggcgccc aagcgcatgc gctcccgggg tctcttccgc tgccgcttcc 1140 tcccgcagcg ccccgggccg cgtcccccgg gactcccggc ccgtcctgaa gccaggaaag 1200 taacctcggc gaaccgggca cgctttcgtc gcgccgcaaa ccgccacccg cagtttccgc 1260 agtacaacta ccagacgctg gtgccggaga atgaggcagc aggcaccgcg gtgctacgcg 1320 tggttgctca ggacccggac gccggcgagg ccgggcgcct agtctactcg ctggcggcac 1380 tcatgaacag ccgctcgctg gagctgttca gcatcgaccc gcagagcggc cttatccgta 1440 cggcggcagc tctggaccgc gagagcatgg agcgtcacta cctgcgtgtg accgcgcagg 1500 accacgggtc gccgcgcctc tcggccacca cgatggtggc cgtgacagta gccgaccgca 1560 acgaccactc gccggttttt gagcaagcgc agtaccggga gacccttcgc gagaatgtgg 1620 aggagggcta ccctatcctg cagctgcgtg ccactgacgg cgacgcgccc cccaacgcca 1680 acctgcgcta ccgcttcgtg gggccgccag ctgcgcgcgc tgcagctgcc gccgccttcg 1740 agattgatcc acgctccggc ctcatcagca ccagcggccg agtggaccgc gagcacatgg 1800 aaagctatga gctggtggtg gaagccagcg accagggcca ggaacccggg ccgcgctcgg 1860 ccactgtgcg cgtacacata actgtgctag acgagaacga caatgctcct cagttcagcg 1920 agaagcgcta cgtggcgcag gtgcgcgagg atgtgcgccc ccacacagtc gtgctgcgcg 1980 tcacggccac tgaccgggac aaggacgcca acggattggt gcactacaac atcatcagtg 2040 gcaatagccg tggacacttt gccatcgaca gcctcactgg cgagatccag gtggtggcac 2100 ctctggactt cgaggcagag agagagtatg ccttgcgcat cagggcgcag gatgctggcc 2160 ggccaccgct gtccaacaac acgggcctgg ccagcatcca ggtggtggac atcaatgacc 2220 acattcctat ttttgtcagc acgcccttcc aagtttctgt cttggaaaat gctcccttgg 2280 gtcactcagt catccacatt caggcagtcg atgcagacca tggggagaat gccagattgg 2340 agtactccct aactggtgtg gcacctgata ctccttttgt gataaacagc gccactggct 2400 gggtctctgt gagtggtccc ctggaccgtg agtctgtgga gcattacttc tttggtgtgg 2460 aggctcgaga ccatggctca cccccactct ctgcctcagc cagtgtcacc gtgactgtgc 2520 tggacgttaa tgacaatcgg cctgagttca caatgaagga gtaccaccta cgactgaatg 2580 aggatgcagc tgtgggcacc agtgtggtca gcgtgaccgc agtagaccgt gatgccaaca 2640 gtgccatcag ctaccagatc acaggcggca acacccggaa tcgctttgcc atcagcaccc 2700 aggggggtgt gggtctggtg actctggctc tgccactgga ctacaagcag gaacgctact 2760 tcaagctggt actaactgca tctgaccgtg cccttcatga tcactgctat gtgcacatca 2820 acatcacaga tgccaacact catcggccgg tctttcaaag tgcccactac tcagtgagtg 2880 tgaatgaaga tcggccaatg ggtagcacca tagtggtcat cagtgcctct gatgatgacg 2940 tgggtgagaa tgctcgtatc acctatctcc tggaggacaa cctgccccag ttccgcattg 3000 atgcagactc aggagccatt acattacagg ccccattaga ctatgaggac caggtgacct 3060 acaccctggc tatcacagct cgggacaatg gcatcccaca gaaggcagac actacttatg 3120 tggaggtgat ggtcaatgac gtgaatgaca atgctccaca atttgtggcc tcccactata 3180 cagggctggt ctctgaggat gccccacctt tcaccagtgt cctgcagatc tcagccactg 3240 accgggatgc tcatgccaat ggccgggtcc agtacacttt ccagaatggt gaagatgggg 3300 atggagattt taccattgag cccacctctg gaattgtccg tacagtaagg cggctagacc 3360 gggaggcagt atcagtgtat gagttgactg cctacgcagt ggacagaggt gtgcccccac 3420 tccggactcc agtcagtatc caggtgatgg tgcaggatgt gaacgacaat gcacctgtct 3480 tcccagctga ggagtttgag gtgcgggtga aagagaatag cattgtgggc tcagtggtgg 3540 cccagatcac tgcagtggac cctgacgaag gccccaatgc ccatataatg taccagatcg 3600 tggaggggaa catccctgag ctgttccaaa tggacatctt ctctggagaa ctgacggcac 3660 tcattgacct agactatgag gctcgccaag aatatgtgat tgtggtgcag gccacatctg 3720 ctcctttggt cagccgggcc actgtgcacg tccgcctggt tgaccagaat gacaacagcc 3780 ctgtgctcaa caacttccag atcctcttca acaactatgt atccaaccgt tcagacacct 3840 tcccgtcggg cattattggg cgcatcccag cttatgaccc cgatgtctcc gaccacctct 3900 tctactcctt tgagcgtggc aatgagctgc agctgctggt agtcaaccag accagtgggg 3960 agctgcgact cagccgaaag ctagacaata accgcccact ggtggcctcc atgttggtga 4020 ctgtcacaga tggcctgcac agcgtgacgg cgcagtgtgt gctgcgcgtg gtcatcatca 4080 cggaggagtt gctggccaac agcctgaccg tgcgccttga gaacatgtgg caggagcgct 4140 tcctgtcacc gctgctgggc cgcttcctcg agggcgtggc tgcggtgctc gctacgcccg 4200 ctgaggacgt cttcatcttc aacatccaga acgacacaga cgtagggggc accgtgctca 4260 atgtgagttt ctcggcgcta gctccacgtg gggccggggc gggcgctgca gggccctggt 4320 tcagctccga ggagctgcag gagcagttgt acgtgcgccg ggcggcgctg gcggctcgct 4380 ccctgctcga cgtactgccc ttcgacgaca acgtgtgcct gcgagagccc tgtgagaact 4440 acatgaaatg cgtgtccgtg ctccgctttg actcgtccgc gcccttcctg gcctcggcct 4500 ccacgctgtt ccgacccatc cagcccatcg ctggcctgcg ctgccgctgc ccgcccggat 4560 tcacgggaga cttttgcgag accgagctcg acctctgcta ctccaaccca tgtcgcaacg 4620 gcggagcctg cgcgcggcgc gagggaggct acacgtgcgt ctgccgcccg cgcttcaccg 4680 gagaggactg cgagctggac accgaggccg gccgctgcgt gccgggcgtc tgccgcaacg 4740 ggggcacctg caccgacgcg cccaacggcg gctttcgctg ccagtgcccg gcaggcggcg 4800 ccttcgaggg cccgcgctgc gaggtggctg cgcgctcctt cccgcccagt tcgttcgtca 4860 tgtttcgcgg cctgcggcag cgattccacc ttacgctgtc cctctcgttc gcgacagtgc 4920 agcagagcgg gctgctcttc tacaacgggc gcctgaacga gaagcacgac ttcctggccc 4980 tggaactcgt ggctggccaa gtgcggctca catattccac gggtgaatcc aacaccgtgg 5040 tcagccccac agttccaggg ggcttgagtg acgggcaatg gcatacagtg catctgagat 5100 actacaacaa gccccggaca gatgccctag ggggtgcaca gggcccctcc aaggacaagg 5160 tggctgtgct aagcgtggat gattgtgatg tggccgtggc tctgcagttt ggtgctgaga 5220 ttggcaacta ctcatgcgcg gctgctggtg tgcaaacaag ctccaagaag tccctggacc 5280 tgacgggccc tcttcttctg ggaggtgtcc ccaacctccc cgagaacttc cccgtatccc 5340 ataaggactt catcggctgt atgcgggacc tgcacattga tggccgccga gtggacatgg 5400 cggcttttgt cgcaaataat ggcaccatgg caggctgcca agccaagcta cacttttgtg 5460 actcaggccc ctgcaagaac agtggcttct gctcggagcg ctggggcagc ttcagctgcg 5520 actgccctgt gggcttcggc ggcaaagact gtcagcttac tatggcccat ccccaccatt 5580 tccgtggcaa cggcacactg agctggaact ttggaagtga catggctgtg tctgtgccat 5640 ggtacctggg gctggcattt cggacacggg caacgcaggg ggtcctgatg caagtgcagg 5700 ctgggccaca cagcacgctc ctttgccagc tagatcgggg gttactgtct gtgacagtga 5760 ccaggggctc gggccgtgct tcccatctcc ttctggacca ggtgactgtc agtgatggcc 5820 ggtggcacga tctgcggctg gagttgcagg aggaaccagg tggccggcgg ggccaccatg 5880 tccttatggt ctcactggac tttagcctct tccaggacac catggcggtg gggagtgagc 5940 tgcagggcct gaaggtaaag cagctccacg tgggaggcct gccccccggc agtgcagagg 6000 aggctcctca gggtctggtt ggctgcatcc agggggtgtg gctcggctcc acaccctctg 6060 gctccccggc cctgctaccc cccagccacc gagtgaatgc ggagcctggc tgtgttgtga 6120 ccaacgcctg tgcctctggg ccctgcccac ctcacgcaga ctgccgggac ctctggcaga 6180 ccttttcttg cacctgccag ccaggttact acggcccagg ctgtgtggat gcctgcctcc 6240 tgaacccctg tcagaaccag ggatcatgcc ggcacctgcc aggagccccc catggctata 6300 cctgtgactg tgtgggtggc tatttcgggc accactgtga gcacaggatg gaccagcagt 6360 gcccacgggg ctggtggggg agcccaacct gtggcccctg caactgtgat gttcacaaag 6420 gttttgatcc caactgcaac aagacaaatg ggcagtgtca ctgcaaggag ttccactacc 6480 gaccgcgggg cagtgactct tgcctcccat gtgactgcta ccctgtgggc tccacctcgc 6540 gctcatgtgc accccacagc gggcagtgcc cctgtcgccc aggagccctt ggccgccagt 6600 gcaacagctg tgacagtccc ttcgcagagg tgacagccag cggctgccgg gtgctctatg 6660 atgcctgccc taagtccctg agatctggtg tgtggtggcc ccagacaaag tttggcgtcc 6720 tggccacagt gccctgtccc cggggggccc tgggtgctgc tgtgcggctg tgtgatgagg 6780 cccagggttg gctggagccc gacctcttca actgtacctc ccctgccttt cgagagctca 6840 gtctgctgct ggatggccta gagctgaaca agacggcact ggataccatg gaggccaaga 6900 agctggctca gcggctacgg gaggtgactg gccacactga ccactatttt agccaagatg 6960 ttcgagtcac tgcccgcctg ctggcccacc tgctggcctt cgagagccat cagcagggct 7020 tcgggctgac agccacacag gatgcccact tcaatgagaa tctgctgtgg gccggctctg 7080 cactgcttgc cccagagaca ggggacttgt gggcggcgct ggggcagcgg gcccctgggg 7140 gctccccagg cagcgcggga ctggtgaggc acctggagga gtatgcagcc acactcgcaa 7200 ggaatatgga actcacatac ctgaatccca tggggctggt gacgcctaat atcatgctca 7260 gcattgaccg catggagcac cccagttctc cccggggggc ccgtcgctac cctcgctacc 7320 atagcaacct ctttcgaggc caggatgcct gggatcctca cacccatgtg ctgctgcctt 7380 cccagtcccc acggccatcc ccatctgaag ttctgcccac aagcagcagc atagaaaact 7440 ccaccacctc aagtgtggtc cccccaccag ccccgccaga gccagagcct gggatctcca 7500 ttatcattct cctcgtttac cgcaccttag ggggactgct ccctgcccag ttccaggcag 7560 aacgccgagg tgccaggctt cctcagaacc ccgtcatgaa ctccccggtg gtcagcgtgg 7620 ctgtgttcca cggacgcaac ttcctaaggg gaatcctgga gtcccccatc agcctagagt 7680 ttcgcctgct acagacagcg aatcggagca aggcgatctg tgtgcagtgg gacccacctg 7740 gcctggcgga gcagcatggt gtgtggacag cacgggactg cgagctggtg cacaggaatg 7800 ggtcccacgc acggtgtcgc tgcagccgga cagggacctt tggggtcctc atggatgcct 7860 ctccccgtga gaggctggag ggcgacctgg agctgctggc tgtgttcacc cacgtggtcg 7920 tggctgtgtc tgtggctgcg ctggtgctga ctgcagccat cctgctgagc ctgcgcagcc 7980 tcaagtccaa tgtgcgtggg atccatgcca atgtggcagc cgccctgggg gtggcagagc 8040 tcctcttcct gctggggatt cacaggaccc acaatcagct ggtgtgcact gcagtcgcca 8100 tcctcctgca ctacttcttc ctcagcacct tcgcgtggct cttcgtgcag gggctgcacc 8160 tctaccgcat gcaggttgag ccacgcaacg tggaccgcgg cgccatgcgc ttctaccatg 8220 ccctgggctg gggcgtccct gctgtgctgc tgggccttgc tgtgggcctg gaccctgagg 8280 gctatgggaa ccctgacttc tgctggatct cagtccacga gcccctcatc tggagctttg 8340 ctggccctgt tgtcctggtc atagtgatga acgggaccat gtttctcctc gctgcccgca 8400 catcctgctc cacagggcag agggaggcca agaagacctc tgcactgacc cttcgcagct 8460 ccttcctgct gcttctgctg gtcagtgcct cctggctctt tgggctcctg gcagtcaacc 8520 acagcatcct agccttccac tacctccatg ctggactctg cggcctccag ggcctggcgg 8580 tgctgctgct cttctgtgtc ctaaatgcag atgctcgggc tgcctggatg ccagcctgtc 8640 tgggcaggaa ggcagcgcct gaggaggcaa ggccagcacc tgggctggga cctggggcct 8700 acaacaacac ggctctcttt gaggagagtg gcctcatccg catcactctg ggcgcctcca 8760 ccgtctcctc tgtgagcagt gcccgctccg gccggaccca ggaccaggac agccagcggg 8820 gccgcagcta cctcagggac aatgtcctgg ttcgacatgg ctcagccgct gaccacactg 8880 accacagcct ccaggctcat gctggcccca ctgacctgga cgtggccatg ttccatcgag 8940 atgctggcgc agactccgac tctgacagtg acctgtcctt ggaggaggag aggagtctct 9000 ccattccatc ttcagaaagc gaggacaatg gccggacgcg ggggcgcttc caacggccac 9060 tctgccgagc agcccagagt gagaggctcc tcacccaccc caaagatgtg gatggcaatg 9120 acctcctgtc ctactggcca gccctggggg agtgcgaggc agccccctgt gctctgcaga 9180 cttggggctc tgaaaggcgc ctggggctgg acaccagcaa ggatgcagct aacaacaacc 9240 agccagaccc ggccctgacc agtggggatg agacttctct gggccgggcc cagcgccaga 9300 ggaaaggcat cctgaagaac cggttgcaat acccactggt gccacagacc cgaggtgccc 9360 ctgagctgtc ctggtgccgt gcagccacct tgggccaccg tgctgtgcca gctgcctctt 9420 acggtcgcat ctatgctggc gggggcacgg gcagcctttc acagccagcc agccgctact 9480 cttctagaga acagctggac ctgctcctcc ggcggcaact gagccgtgag cgactagagg 9540 aagcccctgc ccctgttcta cgtcccctga gccggccagg gtcccaggaa tgcatggatg 9600 ctgcaccagg ccgactggag cccaaagatc ggggcagcac cctgccacgg aggcagccac 9660 ctcgggacta ccctggcgcc atggctggcc gcttcgggtc acgggatgcg ctcgacttag 9720 gggcacctcg agagtggttg agcacgctgc ctccgccccg ccgcacccgg gaccttgacc 9780 cacagccccc acctctgccc ctgtctcccc agcggcaact ctcaagggac cccctcttgc 9840 catcccggcc gctggactct ctgtctagga gctcgaactc tcgggagcag ctggaccagg 9900 tgcctagccg gcacccctca cgagaagccc ttgggccact cccgcagctg ctcagagcta 9960 gggaggactc ggtcagtggc cccagccatg gcccctccac agaacagttg gacattcttt 10020 cctccatcct tgcctctttc aactcctcgg ccctctcctc tgtgcaatct tcaagcacac 10080 ccttgggccc tcacaccact gccacacctt ctgccacagc ctctgtgctt gggccctcca 10140 cgccacgttc tgccacgtct cacagcatct cggagctgtc gccagactca gaagttccca 10200 gaagtgaggg tcactcctga ggggatgacg gcgtggacga ggaacagctg agggcgacag 10260 aggatctagg ctaacaggag agactccagg agtgggggca gatcccaagg cagcctcctg 10320 ctccccagtg gtgggtgccc cagctctacc tggtgtggca gggctgaggc tccatgtgca 10380 tctgtgagca tgcgtgtgac aggtgcagag acgggggact ggagggagac ttttatacgt 10440 tttgtacctt tgtaaccaga gagatgctta tgttattttt cagcttttct gtctcctggg 10500 gggtttgagg ctgggctggg agggggaggg agatagaggg agagatgcag tttgacccca 10560 tttgggtcct gagcaaaccc tatgctcatc tctctctcct tcctggggtg gactcagatg 10620 ggtgggacac atgccttcct ccccctattc cacccccaag ttgatctgag tatcgtcagg 10680 ggcccaaagt acagaattgt tctttgcttt ttattgaatg ctccaaaggc caaacttctg 10740 gggctggggg ttggtcttgg aaacaggggt cctctgactt cctcatgggg gcttgctcat 10800 accgcccctc ctggtggatg tgtgtgttta ttatgtggag tccctgccac ttactgcctt 10860 atgacctagg actgatgctg tggggtgctg gtggagcagc tgatgtcgtg tttacagagc 10920 aaggcttccc tgtctcccac ggggaggggc tcgggcctct agtcagacat tcctgcagag 10980 ggtcggtgga ggggtcattc acctgcccct gcagcaagca aaagttgtct gtggtgccat 11040 ttgattccct gacactgccc cctgcttgaa ttgattccga agggtagggt gggaaggtga 11100 gcaaagggag cagaaacaag ggaattcaag acccagaatg taggtgccac tgcctcctat 11160 gtttacagga tcctccgtgg ccctaggcac ctgggctgca ggaagtgact ccgttccact 11220 cctcctttat tcccttaaaa agggaaaaat gactgttacg accctgttca caaaactctt 11280 acttttgcta ttttgtctgc tgtccagaac tgaagacttt aaaattttgt tactgtttac 11340 aagtccagat tcaaaaaatg tttttacttt gtttacaact caaaactttg agttttacac 11400 tttgtttaca gtagataatt ttttttcctt tgtttccaag tgaaaggtag ggaaagtggg 11460 agagggactt ggaggaccca cctgtgagga ccctgacctg gccatcttga ggggttttct 11520 aacccccagg tctcccaggc cgaaggtcag ccttgagtcc cgtttaacag cagatccaga 11580 agaccttgag agtaggcgtc ctctaaccac gggggagagt ggctgtgcag ggctgggggg 11640 tggtctgtgc agacacctcc tcacccacca ccccatgcat actcttggga agcagcttcc 11700 tgggagatta gaaattctac ttccctgact ggagctaaat cccaccagcc aggacccaaa 11760 ctctccttac cgagaaggac cccagctctt gaagggctga gtggcctgct gggggtggga 11820 gggtgtcttt actatgtcct aggtttcgta gatgcccctc tctggggttc ccctcctcca 11880 gcccagcggc cctctttcct gtctgtgtaa attgttccgt gaagccgcgc tctgttttgg 11940 gaataaactt ctatagaaaa caaaaaaaaa aaaa 11974 <210> 3 <211> 1071 <212> DNA <213> Homo sapiens <400> 3 ccgagcataa atgtgaccgg ccgcggctcc ggcagtcaac gcctgcctcc tctcgagcgt 60 cctcagcgca gccgccgccc gcggagccag cacgaacgag cccagcaccg gccggatgga 120 gcgtccgcaa cccgacagca tgccccagga tttgtcagag gccctgaagg aggccaccaa 180 ggaggtgcac acccaggcag agaatgctga gttcatgagg aactttcaga agggccaggt 240 gacccgagac ggcttcaagc tggtgatggc ctccctgtac cacatctatg tggccctgga 300 ggaggagatt gagcgcaaca aggagagccc agtcttcgcc cctgtctact tcccagaaga 360 gctgcaccgc aaggctgccc tggagcagga cctggccttc tggtacgggc cccgctggca 420 ggaggtcatc ccctacacac cagccatgca gcgctatgtg aagcggctcc acgaggtggg 480 gcgcacagag cccgagctgc tggtggccca cgcctacacc cgctacctgg gtgacctgtc 540 tgggggccag gtgctcaaaa agattgccca gaaagccctg gacctgccca gctctggcga 600 gggcctggcc ttcttcacct tccccaacat tgccagtgcc accaagttca agcagctcta 660 ccgctcccgc atgaactccc tggagatgac tcccgcagtc aggcagaggg tgatagaaga 720 ggccaagact gcgttcctgc tcaacatcca gctctttgag gagttgcagg agctgctgac 780 ccatgacacc aaggaccaga gcccctcacg ggcaccaggg cttcgccagc gggccagcaa 840 caaagtgcaa gattctgccc ccgtggagac tcccagaggg aagcccccac tcaacacccg 900 ctcccaggct ccgcttctcc gatgggtcct tacactcagc tttctggtgg cgacagttgc 960 tgtagggctt tatgccatgt gaatgcaggc atgctggctc ccagggccat gaactttgtc 1020 cggtggaagg ccttctttct agagagggaa ttctcttggc tggcttcctt a 1071 <210> 4 <211> 107262 <212> DNA <213> Homo sapiens <400> 4 ggaactagga aggcggctgg gggcgggtga cgcaggctgg ggtttgccgg ggtggccccc 60 gagcggcgtg tgacttgggg gtccaaggaa gttaaactgg acaggctggg gtgaggacaa 120 tgggggcctg gagaggtggg gcgagaggag ggcggggggt ccccacgagc cgcggtagag 180 gcgaggcggc gggtccgcgg gcgggttgca tcatccggcg gggagggcct gggtcactgc 240 tgctcttccc ccggcgcccc ggccccgaca caagatgcga tttcaccgcg cacctgttac 300 acccggagcc agcatccctg gcgcaaggag ccctccctcc ccagccccgc ccgcccccca 360 cgatgcgtct gtcgctggct cagagcgggg gcaggtggac gttttacgat ttcactcgaa 420 aggggccagg gtgggggacg gcccggcgag gggtccgcgg gcaagttcag gtgcacgcgg 480 ggcttcggga cggggcgccg ccgggtccct cccccgcgag gtctcagggg cacgccgggg 540 gaggggacgc tgcgtccgag ccgggtgtcg gtcccccacc ctccgcgggg cccgccgcgg 600 tgtcagcggt gacgtcacag cccggccccg gccccctccg tccccagccc catccccgcg 660 gcggccgcgt cgcccgtccc tctccccgcg cgacaaacca gctggcgact ggagctcgga 720 cgccgcgcgc agccaaccag cgcctcggga ggggcgcggg gcggtccggg ccgggggcgc 780 gcagcccgtc acgcggcggc gccgtcacag cgcagagcag ccggcgagcg gcagcagctc 840 cgggctcgag agcccgcgcc catgccagtg cccatgcggg gccgccgcca gtgacgccgg 900 agaggtaagg ccgccgcccg cccggcctcc cgcgcccgcg cccctcgccc cgcacctgcg 960 cccggcagcc cgcgcccgca gcccgcacct gcacccactg cgcccagggc ggggagctcc 1020 ggcccggcgc ccttgttgcc gcccaaagcg caggcactgc gaggcccctt cacttccaga 1080 ccttcctcca tctccgcaga gaacaatggg ggaaattcag gggtgtccgc ccttcaggtg 1140 ccgctggaaa aggtcccttt gccgcgatct cggctgcagc gggaccctcg gcttaggcgg 1200 gcgggggtcg ccctcgggag ggctcgcccg gccggcggga tcgggatacc cccgcccttc 1260 cccggctatt ccgcttccct ggagaggagc caccggcggg gctgcgggag gggctgcgcc 1320 cagacggcgg gggaggggag ggatggtgag cggggctgag gacgctgacg ccgcacctgg 1380 gagggtgcgc ggctgcagcg cctcggcccg aggggagagc gcgcagggcg gccgggcgcg 1440 ggcagctgct ccggttcccg gggtggggga gggcggatgc tggagccggg agcaaaacag 1500 gcgggcgggg cgggggctgc ggcgttgggg cctggccacc cgcttcgttg cacggccggc 1560 ctgcccatca ccccctccca cgccagagac cccagctccc ttccagaaag acccagcacc 1620 tgggaggggc cgccggcgag cactgcctgc gtctcagcag ccagcgcccc tgtaacaggt 1680 gtggcccggc ggcgagggag gggctgcggg gccgcagggt ctaggctggc ggcgcgcccc 1740 cggcgcccgg gctcggatga cacgaaggaa cagtggccgc gaagaccttc gcactcccgc 1800 tttaagccgc tcctcacgct gacttccccc aaaccagccg cgctgccctc tcgctgggaa 1860 gggccggggc agcatccccg ccgggaggga gggtccgcag gagcggggcg ctgggcgccg 1920 gtaggtgggg ttgggggggc cctgccggcc gcaggggcgg gagggggagg ggaaggaggg 1980 aatgccaagt catggggcct gctgggcgcg agcgcgacgt cgcccggcgc ggacccgatg 2040 cgcgcccacg tccccgggaa tagggacttt cccccagaga ctggaggacc ccttccccaa 2100 gcgtcagccc tttccaaggg gtgcctgcat tgctggaatt aaaggcctgc cagggcaagc 2160 ggattggatc ttgcggctgc ggagaggagg cggtgcggag aggcccctgc ctcgcagggc 2220 tggcactggc ctcaccctgg ggacgcacag cgcgacaccg tgctcggctc tgcgggacac 2280 caggtcgcac tcaggctggc ggggcctttg ccagggaagc catgccagca ccctcgtggt 2340 gtgagaaggc agcagagggt ttgaagggaa gctctggggt ccacgtgggg gttggggctg 2400 cacctgcggc ggccattttg caggtgtggt tggccaccag ccttagccag gctgtggagt 2460 ggggcagtca ggagtggggc agtcaggagt ggagcagatg tggagcttgc ggtgcagggt 2520 gtgggatggg ccagggccag ggctcaggtc tgcccttgca ctgaacacac accgtctatt 2580 tagaggggtt ccttgtttgg ttgatggggt ggttggagtc aagacccagg aaccctctgg 2640 accggaggga tgaggaggga tgcggtaagg ccgctggctg aggggcccag cgtgggatcg 2700 gaggagggca gcctttaccc ggggtgaagt ctcgggaggg tgctgggtcc aaggcagggc 2760 ccggatgaac agcttcactc cggctgcaga tggatctgag gccctgcagg tgtcctcccc 2820 gggcaggtcc gcagggtgga cagaggctgg aatcagttgt caaggcaggg gtcccgggcc 2880 gggcccaggg aggtccctgt ggtgagggcc tgcaagatgt ctgctgtgtg ccagccctgc 2940 tcccagccgg gtgctgcccc cctgggtgcc tcctttcccc cttccccact ggaatgtccc 3000 acagactgcc ccatctgggg ctccagccgg ccagccacaa acaggtggag cctggagttc 3060 tgcccaaagc ccagggatga tgcttggctg gatcaggatt aaaactgggg tcactgcccg 3120 gccgcccagc ctgtgccccg cagtcctcac tgatgtcatg actgctgacc ttgggcccac 3180 catgcccttt gggagtaggg tagggcagtc ctcctgtggg atttgtgaag ggtggagggg 3240 gagatgtgag ctggaggagg aggccctgga ggagactgag ggcatctctt caggccactc 3300 agccgggccg gccaaagcag gtgaactggg tgtggtgggg acgggaaggg agacgttccc 3360 acagagccct ggtcctacca gattggggtc tatggagggg ctaccagcat taggtcattg 3420 ggatttactg agccctgcac atgcctagct ggccaatccc gtcaggcctg agaccatccg 3480 tgcacatcta tcagtgagct gggaggggcc tgagccgcta ccacgggtgg agagtggtgg 3540 gcctgggtct ctgggtggct gtgattggta ggatgagcac gtggttgtct gcctgcagag 3600 tctggggacc tctctaggtc attgccacat tcagtgttct taggcccaaa ggatgtggct 3660 caccacccac aatatgggtg gccaaaggga ctcaaggtgt cacctcccac tgcccatcac 3720 ccactccatg cccaggagcg tctctgagaa ccatgggggg ctgggccaca ccctgccccg 3780 aacctgtcca tgggtggcca gggtacccag ggacacagcc aggcagcgtt gggcctgcgt 3840 ccttgccggc ttctgcccct taggtggtgg cctccggcca taggcccatc cctgctacag 3900 gagggtttgg gatcccagag ctttgcatcc cagtcctttg gcatggcacc tgggcagagg 3960 caggggcaca gtggccccac ctgacgaagc cagcttgctc tttagctcct gagccccact 4020 gggatcccca ccctcagcct ggctggcctc tcgccacccc agtgccccca cccccagggc 4080 ctcaagaacc cagggaacag ctggctgggc ttggcccacg tgctgcagtt gggggtgctg 4140 tggggcagag ggcacagtca aggtcagcag caggtggaga ctgagcctcc tgacctctcc 4200 tgctccttgc cagcccatcc tgccagcttt ggcctcctgc aggcctagtg cattgtagag 4260 attgatccgg atgtgtggat atgggacttg gatgtgggac tcagaggctg gggttgccgg 4320 aatgagtagg aggggctgct gcctctctaa agcctcctca ccctggattt aatctcctaa 4380 tcccaggcct tgtggtctgg gcaggcccag ccctggctgc cacagagcct ggggattcag 4440 atgacctttg ggggtccctc ctgcttgcca tccctgccag atttcaggac gccttggggt 4500 atagggaggg caggccagtg cctggctctc caggcatcct cgtgcttatt cctcacccct 4560 ccccacagtg ccctggaggg gtccagagca gtcacccggc cacacacact catagtcaca 4620 tgcatccact cgaacacaca cagatccaca tgcatataca catacacaca cattgcacac 4680 acactgacac acacatgcac gcacacccac ccatgcatac attcacacac acagacactc 4740 atacacacac atgcatgctc atgcacactc acatacccac acatacattc acatacaaac 4800 acacatacac acatgcttat gcacgcatgc atacacacat gcatgcatgc agatagacac 4860 acacacacac acacactctg catcccttgt ccctgtcttt gttcttgcct gggtttcttc 4920 tcaatacttt ctactcaacc tccacattag gttttaggtc cccctcaaat gctgcctctg 4980 ccatgatgcc tgctgtcacc cctacccctc agattggcac cccctccaca accataggtt 5040 tccaggggtg gggaagaaga cagagaacac tggtcatagc ctgcactgtg cacctcatgt 5100 gcttcccttt atcccatgcc actccacacc tgaacaatga gaacagcacc gcttggctcg 5160 gaccccactg agccaggtgg tggtgttccc attttccagg tatggagact gaggctcctg 5220 agaagcccat gtggcttgta aagtgaggac ctgggactcc gaggatggta gctcctttag 5280 tgctttctgc tcatccctcc actttctcct ccacccccat taccccccac ttctcccacc 5340 cccacggggg ccagcacggt gcctcacaca gagtgaagac tcagtcagtg ctcttccatg 5400 gctgagccgg ttgttctagc ccaggtaccg cattttctgg tagagtccag gttgagcttt 5460 ggccaccctc tcaggggttg gggtgtcttt gggtctcagt gtctcttgtt cagaacctat 5520 ggattcctga gcctggctta ggaatgacag gcaccccctt ccctctgggc ctcccgtggg 5580 gctcctgaaa tgcagctcta gggacaggca tggccccgga ctgctcctgc agggcccctt 5640 ccctgaggct ggtagtgcca ggaatgccct caaggggttc ctgcccccac ctcagccctg 5700 ccagaaaggc ccacctgagg gtgggcctca gtttccttct ccatctgtca tcagctcaag 5760 ccaggatggt gcaggacagg gctgggcagt caatgctcaa ggtcatgggt cggtgtggct 5820 cctgaggagc tgctgtgggg ctggggtggg actgtactca gttgcttggt gtcatctggt 5880 ccccactctc ctgcttctgg ggccagggcc ccaccatggg tgcaggtcct tggggcctgg 5940 gagggctgca gctctaggac aagtagtggc tgcagtgggc taggcgcaga ccagaggagc 6000 acgcttacgg ccccacaccc tttgcgtcag ctctgtactt aggcaagatg ttcttggttg 6060 gtgttttatt ttctccagct cttggttatc tttattttat ttcattttag agacagggtc 6120 tcactctgtc acccaggttg gagtgcagtg gtgcagtcac agctcaccac agcctcaacc 6180 tcctgggttc aagtgatcct cctatctcag cctcctgaat agctgggact atgggcatgt 6240 atcaccacac ctggctaatt ttttgtagac ggggttttgc catgttgccc aggcaagtct 6300 tgaattcctg ggcttaagca atcctcctgc ctcggcccca caaagtgctg ggattttagg 6360 tatgagccac cgcgcccagc ctttttattt tcttgaatga gttttttccc ttttatcgca 6420 cctccagaag tggcctctgg cagctgcttg ccatgtcccc tggattggag tttctgtttc 6480 ttggacccta gagctgcttg tttcttggtt tcctgtcttg ttttgctgga gcacatcctt 6540 gtgtgacttc cttgaaaggg tgcatgagtc tttggtgtgt gagagtgttt ttgctgtgtc 6600 cttgctctgg gtggtagtgt ctggggtact tctgttccta agtagctttc ctgggaactc 6660 taaggatagg gtcaccatgg ctttctgcat caggtcactt atgagcaggc tttgttggca 6720 actcgtcttt tctccctgga agcttttagg atcctgtctt ttccttggtg ttctaacttc 6780 atgtcgacgg gtgtaaggat ggggttcgca tttattggca ctcggtgggc ccttcacact 6840 gaagtcaggg tctctacttc tatttgttcg taatttcctc cttttcattt tttcttttac 6900 cctgaattca tgggttggtc tgtttggttg cttttctctt gtatattctg tctccttgtt 6960 tatattctaa agtcctttga ctgccttttc tagggttttt ggaatcttgt acttcatctc 7020 ttacattttt catctctaaa atcttcacgt ttctaaatgt tctgtctcat agcattctgc 7080 ccttgttttg aaaatgagca tcttcttgaa tctcccgggt gcgtggacag aggttgtgct 7140 cggttgtttc gcgtctgttc catgctttgc ctgtccttcc cgcagggcct gttttctgct 7200 ggcagctctg gtccttccct ttcacactct gttctcacgc ccgaggaagg cattagttgg 7260 cacatcatgt gttagggagg ccattggcgg gagcggcagg gctgctgctg ctcaccccgg 7320 agtggttctg accagagctg gggtggggtg tccatggggg gtggggtgtc catggcaggc 7380 cctggcttag gtgaaggggt ggggctggct accaagctgc ccctgcatat cagaatgagg 7440 ggtactgcat tcttcagctc actgaaggct tcactcctgc tatggagaaa gccattcagc 7500 tgctcacctg ggggcactgg cagtgaccac cctcggaggg tggatggcgg ggctgggggt 7560 gcgggcttcc atgttagcct cacttctcac ccctgccttc caccaggtgc ctgagttccc 7620 atgcctgagc ccctgcccct tccctgccct ctgcaagcgg cactcagggc tgaggtccca 7680 ggaaacgcct ctcccacgcc ctttgcagtt gggggctgtg tggtgggctc tggccctatc 7740 ccatggggtc tcagagcaac cagtgtgcct gcagtcattg gacctggggc tccttactct 7800 ccaggggtgg ccaggacact cctctatgac aatcggttgt aattctaaga aaaacctgct 7860 gtggtttttt tctcaaactc ttcaagaagg atcagtgttt caggaagtgg cccatgccga 7920 tgctttgttc tgggctggcc ctgctgggtg tgcacatggc gggccacttg tctaactggg 7980 agcaagtgga tccttgaggt gaaggcagat ccccgaggtg aaggcggatc cccgaggtga 8040 aggcggatcc ccgaggtgaa ggtggatcct tgaggtgaag gcggatcccc gaggtgaagg 8100 ctgatccccg aggtgaaggc ggatccccga ggtgaaggcg gatccccgag tgaaggctga 8160 tccccgaggt gaaggcagat ccccgaggtg aaggctgatc cctgaggtga aggtggatct 8220 tgaggtgaag gcggacccag aggtgaaggc agatcccaag gtgaaggcgg atccccgagg 8280 tgaaggcgga tccctgaggt gaaggctgat ccctgcctga ggtgaaggtg gatctcgagg 8340 tgaaggctga tccctgaggt gaaggtggat cttgaggtga aggcggaccc agaggtgaag 8400 gcagatcccg aggtgaaggc agatcctgag gtgaaggcag atccctgagg tgaatgtgga 8460 tcccgaggtg aaggcagatg tctgaggtga aggtggatcc ccaggtgaag gtggatcccc 8520 aaggtgaagg cagatcccga ggtaaaggcg ggcccctgag gtgaaggcag acccagaggt 8580 gaagggcgtc tgggctccag gcggatgcct gtgcgatgct ctgcagcatg ggcctctcca 8640 gcagctgggc agggagtgcc tgtgccaggc ctgtgtctgg ccctcaccgt caccccatgc 8700 ctggtctttc ctggacactc ctcgagctga ggcacgcttt gtcatctgcc ttggtgccac 8760 ccccagcccc cttccacagg gacttggctt tttctgctga tgcccccacc ccagggtgag 8820 gcaggaacct gaaatggtcc cagagcccca aagcaacagg ggagttcctc cggggccacc 8880 ctgccctctg tgcctgcagt gacttgcggg gcgtggcccg gtgcgcccag tgggttttct 8940 gcatgcattt ttaccaagtg aatggattct gttcccctct cctctgtcct ggggcccctg 9000 gctcagggct catggtctcc ctttcctgga gtcatcacag ccggctggcc atacccacat 9060 acccacatgg atggccacca tcccccagcc ctctttccct ctcctgccct cgggccatct 9120 tctctgccca cttcctgtgg gtgcatcctg ggtctagtca gagcctcaga cacccgtggt 9180 gttgcctcta tgtccccagc gcagacccca ccctgccacc accagcttct cggcatcttc 9240 tttggctctg agcagtcatc ccaacccctc tggcttcctc cctgccaccc ttgagcctgt 9300 gccctcatct ctggccactc cagccagcgt gacctcaccc cacaggacca gttcatgctt 9360 cttgtttctg atgacttcct gccccacctg tcccagaggt gcccctctct gtctttgagg 9420 ggagctcacc ctttctcctg ggctctggca tgtgctgtgt ctggcactgt ggaccgcaac 9480 cccccgcctt ctcaggggtt cagctgtgtc agacccccat cctcagcttt gccttctgcc 9540 atcagccacg cccataggct ctggccaccc ttggggccac gtggctccct ctcaggttgg 9600 ctgacagaac aacttcttga agatagtttc ttttcttttc ttttcttctt ttcttttttt 9660 tgagatggag tctcacgctg tagcccaggc tggagtgcag tggcgcaatc tctactcact 9720 gcaacctctg cttcccgggt tcaagtgatt ctcctacctc agcctcccaa gtagctggga 9780 ttatgggtgc ctgccaccac gctgagctaa tttttgtatt tttagtagag acagggtttc 9840 aacatgttac aagccagggt ggccactaac tcctgacctc aagtgatctg cccacctcgg 9900 cctcccaaag tgctgggatt acaggcacga gccactgcac gcggccaata gttacatctt 9960 taaaaattgt gtcatgtggt agcaaaaata tacaacaagg aatacagaat attacaacca 10020 acggccacat gcccacatta gctttcaaaa taaggcattt ccaacctgct ccccaagggt 10080 agcactggca gagggctcac caccacccgg catctcggcc gacccacatc accctgggga 10140 ggaagacgga cagatggggc ctggcgggaa ggaggtcctt ccacgtcacc atggcgggca 10200 catcgagtgg ccttggtggc gtccaggccc ttagaccccc tccacgccca gcaccatgaa 10260 ttcggtgctg atcgctcctg gagtgtcatc gtctgccctg agtctgtgga gtgctgcttg 10320 tgtgtttgaa acttcgaggg gcctgcagcc gactctgcat tcatctgcat cttggatgct 10380 gggcatttgg gctgtctcca ttctttttgt aatgataagt cattctgcat ttgggtgtat 10440 ttctccctgt gaatatgtat agcatctcta cttgcagagt tgctggggca caaggtctgc 10500 agcccctcca gatgttacca tgttattttc aaagtggtgg cacccgttca ctcccaaggt 10560 gagctgtaaa agctcctgtg gcctccttct gacagcgttt ggtgtgccct acttttaaat 10620 gttgccatct ggtggataca gtttgaaaat atggtttccg aattactatc gtggttgagt 10680 atcttttcat gtaaattgcc agttcatatc tttttgccca ttttcttctg tgatttttgt 10740 aaatttttat ttttatctgt cctctgtgta ttctgcgtac aaatccttcg ttgaattgta 10800 tgtgttgcag ataccttctc caggtgggtg gggttctcgt caccgtttta gtgatatctt 10860 ttgataccca aactttcatt ttggtgtttt cggtgggtta agaaatcttt ccggctgggt 10920 gcggtggctc gcacctgtaa ttccagcgct ttgggaggcc gaggtgggtg gatcacttga 10980 ggccaggagc ttgagactaa cctggccaat gtggcgaaac cctatctcta ctgaaaatac 11040 aaaaaataaa aataaaaata aaaataggtg tgatggcaca tgcctgtaac cccagttact 11100 tgggtgactg aggcacaaga aactcttttt ttttttttta ttatacttta agttctaggg 11160 tacatgtgca caacgtgcag gtttgttaca aaggtataca tgtaccatgt tgatttgctg 11220 cacccatcaa ctcgtcattt acattaggta tttctcttga atcctggtgg cagaggttgc 11280 agcgagccaa gattgcacca ccgcactcca gcctgggcga cagagtgaga ctctgtctca 11340 aaaaaaaaaa aaaaaaattc cttccctagg ggtagcgtga agatataact cttctttatt 11400 ttcttccaaa acattttttg ttaacataga ggtctttaat ccacatggaa tttatttgac 11460 atataaaggg atctaatggt gtattctcca tattgccaac cagtgttcct tccatcgctg 11520 gttcggtcgt ccgtcctctc ccccttgctc tgtaaagcca cctttcccag atgtcaaaag 11580 ggctgtgctt ctgcaggtct gttcctgggg tcccttctgt tgcactcgtg atggcctctt 11640 cctgtcccag cacagcccga cttcatgcca gggctttcta ccaaggctcg agatcatagg 11700 gcgtgttgcc ctctgccctc tggtcttttt tttcttcttc ttcagacttg ttattgatgt 11760 tcttaacatc ttactctacc atatacattt ctagaagcaa cttgtcatga ttcacaaaag 11820 aacttgagtt ttcatatgaa atgacattga gtttttgaat caatttgggt aaaattaaat 11880 gttttcaaga tattgagatt tattttccac caataagtta tagttctcca tttatttaga 11940 ttttccgcaa tgtttttagt aaagttctac aattttcttt ataataagtt agtgacggct 12000 gggcgtggtg gcttatgcct ctaatcccag cactttggga ggctgaggcg ggcagatcac 12060 gaggtcagga gttcaagacc agcctggcca acacagtgaa accccatctc tactaaaaat 12120 acaaaaaatt agccgggcgt ggtggtgggc gcctgtaatc ccaactactc gggaggctga 12180 ggcaggagaa tcacttgaac gcaggaggcg gaggttgcag tgagtcaaga tcgcaccgtt 12240 gcactccaat cccaggcgac ggtgtgagac tccatctcaa aaaaaaaaag ttagtgacat 12300 ttattcctag gtactctata gtttgggtta ttattttatt tatttatttt ttagagagaa 12360 gatcttgctc tgttgcccag cctggagtgc agtggtgtga tcattagctc accgcagcct 12420 cgaactcctg agctcaagtg atcctcctac ctcagcctcc caaggagctg gtactacaga 12480 tgttgccact actcctggct aattaaaaaa aaaaaatttt ttttttttgt tttagaaatg 12540 ggtcttgcta tgttgctcag gctggtcttg aattcctggg ctcaagcaat ccttctacct 12600 cagcctccat ggtagctggg actacaggtg tgagccactg tgccaggttg ggttattatt 12660 ttaaaggata ccttaaaata tgttttaatt ctttatcagg tatataagaa tgttcttgat 12720 ttctacaacc ttattgaacc ttcctaattc aaatattttt tctgtggatt ctcttgattt 12780 atgtgtagat gagcaaatgg tctgcagata atgacagttt ggtttctttc tttcaaattc 12840 atatttatgt tgtttgttat tttcctgtct tactggtttg gccagaacct ctcctacaat 12900 gttaaataga agtagagata gcaagcatcc tggacttgtt tctgaatata aaggaaatgt 12960 tcctatcatt ttaccattaa gtgtgatgtt tgggtaggtt tttagtagat agctattatg 13020 aggttaaaaa agttttcttt tattctaata ttgcttagaa ttttatcaca aatgagtctt 13080 gaaaattatg gaatgctttt ttagtatcta ttgagggcct catattcttt cttctttaat 13140 ttgaaaatta taataatagc tatcctaatg tcaagctata ctggtattcc tggaatatgc 13200 ttacctgcat tgcccttttt atttgttact gtattttctt gctaattttt cagacttttg 13260 tacctatgtt catcagtgaa actggtctat aatctttctc aattttttct tgtttacttt 13320 gatgctaaaa ttctattagc atcagtgaat gagctaggag tacagttggc tctcgatatc 13380 tgtgggttct gcatctgtga attcaaccag atcaaaattt ttggaaaaaa agaatggttt 13440 gtctatactg aacatgtaca aatgtttttc ccttgtcact attacctgga caatacagta 13500 tagcaactat ttattaatac atagcattca cattgtatta ggtattataa ctaatcttga 13560 gatgatttaa aatatatgga aggggctggg tgcggtggct catgcctgta atcccagcac 13620 tttgggaggc cagcgcgggc agatcatctg aggtcgggag ttcaagacca gcctgaccaa 13680 catggagaaa ccatgtatct actaaaaata caaaattagt tgggcatggt ggtgcatgcc 13740 tagtggcgca tactagggag gctgaggcag gagaatcgct tgaacccggg aggcagaggt 13800 tgcggtgagc tgagatcaca ccattgcact ccagcctgag caacaagagt gaaactctct 13860 ctctctctct gtgtatatat atatatatat atatacacac acacacacac acacacacac 13920 acacacacac acacacacac acacacatat atatgaggat gtgtaggtca aatgcaaata 13980 gtacaccagc tcatatgagg gacttgagca tctgtggatt ttggtatctg tggggggtcc 14040 tggaaccaat ctcctactga tactgaggga cgactttata ttctttgggt gtttccctct 14100 ctttcctcca ttctcataaa gagtttgtat aggactgata ttatctttta aacaaatgta 14160 tggtggaact cacctataag aagtgtctga atctgctgcc tttttttgtg ggtagatttt 14220 taaactattg gatcaatttc tttaataatt gtaggaaaat tcatgtttct attgcttatt 14280 tttctcatag ttatgcatca cattttcctg gttcttggca ggtctagtaa tttttgattg 14340 gatgctagac atgattttta gtttttagag agtctgactt ctatttcttg ctttagtgca 14400 tgttgggctt tgtcttggca ggcgcttaac ttacttgaag accagtttga tcagtcaagg 14460 cctgttctta agcttttcta gagctggtct agagtagacc acctgcagga atagtttagt 14520 cccccaccta gggcatgcct tctccagggt ctccacggaa tatctggagt ggaggctcaa 14580 gaggactccc tgttctggct gataggatca cagatgtctc cttaccttgt gtgagttttg 14640 agaattgttc agattacaac ggcccagtct ttttgtgtct ggattatcca ggaatggact 14700 agtactctga aaagactcaa gtgtaccccg gtgcaaattt ctggacttct gctgagcagc 14760 tcctttcttc cagaactctg actcacaacc tccagctgcc tctgcccacc caaactctga 14820 ccaccatctt ctcaacctgt caaagctgcc aaggcgcttg ggtcctacct tgctgtgcct 14880 gcctccaggc agatttggag tgatcacagg gctcacctag tatgtgcccc ttctctcagg 14940 gatcacagtc ctgcactgcc tattgtctga tgtctgaaca ccagtatttt cgtatatttt 15000 gtcttctttg ctagttattg tttacagtga gaggttaagc ctggtccctg ggactctgtc 15060 atggctggac atgaaaactc catgttttgc tattagtgtt ttcatttcca tttagtaagt 15120 atttttatat tttcatcatg atttttcctt tggtttgtta tttagaagtt tattttttaa 15180 atttctaaac atatgggttt ttaattattt ttaaattaat ttttagtcta attgtgttca 15240 aattacatga ttcattttat acaggtcttt gaaagctact gggagttgct ttatggtcta 15300 gtacatggta aaatattgta aatgttccat atgtaatgga aaagaatgtt gctctaattt 15360 tctgcgagag gcacatatgt ccattaattt atgattattg tgttattcat gctatgctct 15420 tattaattat atatctgctt gatctaccaa ttagtgagaa gtgtgttaaa atccctgtca 15480 tgataaatta atgaattcct ccatattact tgactctgaa ctttggtttt atattttcgc 15540 cctttttttc tttctgggat cattttgggt aatttttttc tgacatattt tccagttcat 15600 taattctgtg ttgagctcca tttaatttgc tgattagcat gtctgctaag ttttcagttt 15660 taaataatta cattttattt ctaaaagttc tgcatggttc tttcccatat gttaccccat 15720 tgtttttcag ttctgcttat ttcttagaac atttaagcca acttattttt ataatctgta 15780 tttcacaatt ttaatatctg aagtcgctga ggatctaatc cctctcttcc ctttctcttt 15840 cttctccctt ccctcccctc tccctcccgc ctccctcccc actcccctct ccctccgccc 15900 tccctcccct ctccctccct cccctctccc tcccctctcc ctcccctctc cctgccctct 15960 ccctcccctc tccctcccca cttccctccc ctcccctccc cttcccttcc ctttccttct 16020 tctctcctct ccttttttgg tgactcttgc ttatggtgaa ttgcttctcc cagtgtttgg 16080 taatatttca ttgtgagcta acatttggct gatgttcata tgtgggaatc ttggggccct 16140 gggaaaggaa gccttctcct gggaggattt gtatgtgctt tgttaggtgc tttggggcct 16200 aactcctgag aactactctg agctaacttc ttgaatttgg atttcactga tcatgcaggt 16260 gttgtaaatt tgaaacccaa actttatgag gacaggcctg tggccttaaa ttctcagtaa 16320 cacttgcttt ttcaccacct agagctgggc gtcattcaga ttaattcccg tgtcccttct 16380 tttacccagc cttccatttc acagaggctg tagctttgaa ggattcaatt ttgtggtgac 16440 ttggttccag tcatcacttt ttgtctcttt gaggtcctgc ctcccattcc ccccacagca 16500 ggtgaaacca aattctctgg tttctggtat caccaaatgc ctgtagcttt gttgccacct 16560 taattccatc tccttcttcc tctttttcct ttccttctga ggagtcctct aattttcttc 16620 tgatgtttgt tatttatcct gaatttctag gtgctttata atggagggtg tctcacccac 16680 catactgcag aagtagaagc ttccattcag cccttttgct ctctgttggg aaatattatt 16740 gttattatta ttactttttt gagacggagt ctcgctctgt cacccaggct ggagtgcagt 16800 ggcgtgatcg tggctcactg caacctctgc ttcccaggtt caagcaattc tcctgtgtca 16860 gcctcccgag tagctgggat tataggtgcc caccaccaca cccagctaat ttttgtattt 16920 ttagtagaga tggggtttca ccgtcttggc catgctggtc tcaacctcct aaccttgtga 16980 tccacccacc tcggccttcc aaagtgctgg aattacaggc atgagctacc acgcctgacc 17040 cgggcaggaa atattaattt taatgagcaa actgattttt gatttcacat atatcagtat 17100 ttgtcaacca aaatgaggaa tttctattta ttttacctca actgtttggt aatgattttt 17160 taaaatgatt ctttttaggt taagtatgag cacagtgtag aacaatcaaa cattttataa 17220 aatttgttta gaaaatcagc agcctttgtt cctcataccc aatttttttc aactctctta 17280 gctgttttta aaatttagct gtatattact aattaatgtg cttgttctgc taattcgtgc 17340 ctgttttagc ggttatgtag atagaattat aaactgttta cccttttgca tttggtttat 17400 ttttttccat gtcctgtttg tggtattcat ccatttatca tctctccctc ctgaaatgcc 17460 actaaaataa aggtaaaggt aaaccaaaaa aagacctaaa cgctcccata agaatgaaac 17520 aggagagaac gctcagcagc cacgttctgg atgctgaaaa gcagacctgc gtggagactg 17580 atctagaaga ttcacaagag tggaagcctg ggtccctccc aaggcaagcc ttggtgacct 17640 cctgaaagtc ttcccaagcc aaccacagct ccctcgggga cactggggtc tgaaccaacc 17700 tggggatgat gtggggctgc cctccccatc cctgtgcctt taaggctatg tgtttcctcg 17760 tcagtccggc tttagctacc ttccgcagga cctttgccac agctttgaaa tgtatcttca 17820 ttatcactca ttcaaaatgt tttctaatat ccagtgtgat gacttctttg acccatgggt 17880 ttttaaaaat tgtattgctt agtgtccaag caattgggtt gttttgtagg tgattttttt 17940 tgagggtatt gatgtatagc ataattctat tgtggtcaga gaacatctgc cttataactt 18000 gaatttaaga tggatatttg tggaagtttg ctttatgacc agcatatggc aaattttagc 18060 acacattctg tgtgcacttt aaaagaatat gtatgaggct gggcatggtg actcacacct 18120 ggaatcccag cactttgggg agctgagatg ggaggatcat ttgagcccag gagcccaaga 18180 ccagcctggc taacatagtg aaaccccatc cctacaaaat aaaaaattta gccaggtatg 18240 gtgacatatg cccatagtcc cagctcctca agaagctgag gcaggaggat tgcttaagcc 18300 taggaggtaa aggctgtagt gagctaagat catgccactg aactctagtc tcagagacag 18360 gagacccggt ctcaaactaa ataaacaaaa taatgtgtac gatatatatt ttctcctcct 18420 cagtggctga tagaacaagc acaaattttc atccttttgt tttcagcctc tctgtgtctt 18480 tgtatgtaga gtctcttatg aacagaatat aatttataaa aatctggtct gacaattttt 18540 aatgttttac ttggtgtatt taattcatac tgagttgacc ttttatctgc aatcttaact 18600 ctttcttttc cacttgacaa ttatgttttc atattctgtt tttctccttc actgccttct 18660 attggattca tacaataaat tttaattttt tggatatttt tctattaact tgttagttat 18720 acattagttt tctactttct aaatgattac cctagcaatg acaacatgta tccttgacaa 18780 tcgaatataa atgattactg ttacctcttt catgatcatg ttgaaatctt gcagtcttgt 18840 cttttggttt ctatcatttc tgttgaggag tcagttgtca atcttatttt tgctccttta 18900 aaggttacat gctttttttt tttttttttc tggctgactt taagcttttt ctcttcatcc 18960 ttggtcctag cagtgttgca gtgctgtgcc ttgtgtggct ttcttgtttg tcttgctttg 19020 tgtttgtaga gcttcttgaa cctgtggatc aatgtgcttc agcagctttg gacaatccat 19080 ggtcattagt tttgtaaata ctgcttctcc cctgttttgg tccattccag ctgatacaac 19140 aaaaatatca caaacagggt ggcttgtgaa taagagaatt tatttttcac agttctggag 19200 gctgggaagc tcaagagtaa ggcacattgg ctgaggatct gctttctggc tcctagacgc 19260 cttcttgccc tgctctcacg tggtggaggg gctgaggggt gtctctggca tttctttcat 19320 aagggcatga tcccatttgt gaggccccac cctcatgacc taatcacctt ataaaggccc 19380 cacttactaa agtcatcact tggggggtta ggatttcaac ataagaattt ggatgggaac 19440 aggggacaca aacattcaga ccatggcacc cccattccat ttcttctcct tctagattcc 19500 acttacaggt atgtttgacc atttcactgt gtcctatact tttctggctg tcatgtctat 19560 atttcctatt ctttttatct gttttaaatt ttctatattt ctattacctg tcctccagtt 19620 tactaacact gtcttcaact gtgtctatct cttgagttcc taattttagg tattttgttt 19680 tccagatcta gcatttccat ttgatttttt tttttatagt ttccagtcct ctggaaaaat 19740 tctccatttt ccatttatat tctctgtcct ttttgctctt attttgaata tatttgtcag 19800 ggttgttcta aagtccttgt ttaataactc ctagatctgg atcatgttta gatatgtgtc 19860 tttttttttc tcatgtgttt atattttatt tttcctcttt gtttttaatc agagtccttt 19920 cttattttat accttctaag ttttgattgg atgtcacaca ttgcctatta aaagaatgta 19980 gagtacagag attatcctgg gtttgaaaaa ataaaaataa aaataaaaga gtgtagaggt 20040 tccagatggc ttccattttc tctcccaggc agccagactg aagtccgaat taaaccaagc 20100 gagggcaggt tgtagttttc ataaggttcg tccgagctat ggctctgccc tgctcttagg 20160 tttcgtacct tgctgggctt tcagccagag cctggtgtga tcactgggta ttctcctccc 20220 ggaggaccct gaactcaaat ctttgttcct tcccacctga gactgtgcaa gactcctctt 20280 tggttttcag cttgggtttt taaaatctca cctctcatat cctcagaatt tggcaaatgt 20340 cttaagggaa ggactgggca tttgttcatc ttagttgttc acctctgtct tctggaatct 20400 tggcctctca agtttctttt tgcccaaaag ctctgcagct tcctccgtcc ctcagcaacg 20460 gctctctgtc tgggaagact ccagattccc agtctcttgc cccgtgcgca gaatgcaaat 20520 acaccccgga ggctgtgctg cggaggccag ctcccgtctt ggcagcccct cctctggaat 20580 gttggcttgt ggctgcacac tgattccttc acacacagtg cggcgtggta tcgggcctct 20640 tgagtaatgc attggtcggc tgctggccac tgcacccacc aagccgcctt cgccttccat 20700 gcttcgtggt gtgcatattc cataccccag agccaagaac agaggcttct ctgtgtcctt 20760 gtaccacttt tacattttaa agatcaagtt ctagaatagc tttatttttt caatacggga 20820 gagccagttg tcccatactg atcttacctc attccctaaa ttgctgcctt tttctttagt 20880 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ctgctttgga catgcttagt 20940 ctgttcacgt gtcatttcta gactttggaa atcattgtag ctctgtagga tatatgatag 21000 ctggtagggg atgtttcctc tctttgttct catttttcaa aattctctta tcctgccaaa 21060 ttccattgaa catcctgttg gaatattttg cttatcggaa ttgcactgaa tttatatagc 21120 taaatttggg gagaactgga aattttgcac tgttgaatgg aatatctgct ttcatcaata 21180 ttttcttaat ttctaagtat ttccgatttt agtacttggg attactgagt caagggatac 21240 agaccttctt aaaggcccag ggcgtgctgc agaattgctc cctagaaacc ttgcgggatt 21300 tgtgctctag ccagggactg gtgaacttgc ctgttcctct ctccatcccg gctggaacgt 21360 cctaagactt tttccagttt taaaagtgca gggattttca acacaaggaa acacagattc 21420 tcagaggtca tccccccgtc cacgctggca gccactcctg gctgtgagaa gagatagtgg 21480 cggaagcact ctggagtgta gacgcggctg cacctggtgg ctctaagggg ctgtggtgta 21540 ggcggcacga gtccagccac atcaggaact tgtccccact tagccatagg gtggcctggc 21600 acatccccct cccctgtagc ctctggaaga gctgtttgcc tgagggacag ccctgcccca 21660 catccagcct gttctgcgga ggagttctgg ggagcctggg agtggcctgg gcaaggtcca 21720 ggagttcagc gtctgccctg gtcccaggct cactgtgccc cctttccttc tgcagacaga 21780 cccttcctgc tcttgatcct gtcccaggct cgctgtgccc cctttccttc tgcagacaga 21840 cccaggcttg ctgtgccccc tttccttctg cagacagacc cttcctgctc ttgatcctgg 21900 agcttccagg ggcagcccag aggggcttgt cccttcttca cagctatgag gctggggcac 21960 tgtaggatgg gggctttttg ccagattccc ccaagggtgg cacttacaga tggggacgac 22020 caggcagaag gttgcctctt catggaatgt cagtgtggaa gggtttcaag gaggcctccc 22080 agcctttgct ctacttggat gcctctggtg atgtgggact caccactgag tgggcaccct 22140 agagcattta gacagcaatt ggcgaaaacc tctcgtgtca ggctgcatga attctgtttc 22200 atggagttct ggccattcct gtaaccaaca gctctgtccc gaggctgtcc ctgtccctgt 22260 gcccaggagc cccatcgttc aggccgcaag tcccacgggg aagcagcagc atctggctgg 22320 tcagcccgga aagacctttc acagtggctg cttcgtcact gttttgcggg gagttttcat 22380 cagccttcct cagagtccca gtacccgaga ggccaaatca ttttggggtt cctgaccacc 22440 accccgtcat ttcacagacg gtaaactggg gcccaggaag ctgtcacaca gctggggtaa 22500 aggccaggcc gaagctggtc ccccagccct ggcttgtacc gaattcccca tgacttgtct 22560 cctgcttctc ctcagtgggg ctcaggaatg ttcctctcca ccttctgcgt gaattaccag 22620 caggacattg ggccgaaaac gttgactttt gtcccattgc ttagggctgt ctgtgctgtt 22680 cttttcattt ctgagtaaag ttctttcttg ctaattcaga gaccacacta ctgctgatgt 22740 ggctaccagc tggcgcttgg tgtgaagggt gtgatggggc attctagaac actgttctgt 22800 tttaaagcgt ccttgacatg tcgatctgga gccagcactg gctcttgggg cctgcgcgga 22860 cctggcatgg agcccaccag cgcctgcatc cacaggggaa gacccttcct ggggggtttg 22920 ccgtgggtgt gaaggccacc ttcacgttca cacccaggtc gctgtgtttc tgtttctttt 22980 gttgggtttc agcttcctca ggcttgcgaa gctgggttcc actggtcccg ctgggctcct 23040 gctttctaga attatctgcg ctgcctcctc tccttgtgga ttccacccca tgcatgtatc 23100 acactgggag ctttggaggg gagtggaaaa gacctgtggc ttcagctgca gccggagtgc 23160 ctgtcctgcc tcctcagata ttgtttctaa ttcatgtttc ccttttttcc aaggtgttcc 23220 ccccacactg gggctcccac tactgcgagg agtgacccac gaaggccaca gagatggccg 23280 gggcttcggt gaaggtggcg gtgcgggtcc gccccttcaa ttcccgggaa atgagccgtg 23340 actccaagtg catcattcag atgtctggaa gcaccaccag tgagtatcag cctgcacagc 23400 atcggggtcg gccatgggtt gctgggggcc atggtcctgt gcctatgggc caggctcagc 23460 agtcaacctg gccctggccg caagagcacc tccttgtcta tgtggcgtgt gggtgtcctg 23520 gggctgctgt aacaaactgc caccaacggt ggtgggctta taagaataga gatttacgct 23580 tacagctgtg gaggccagaa gtccaaagtc aaggtgccag cagggcctca ctctctctga 23640 gctcctaggg aggacctttc ctgccttctc cggggtctgg tggttgccag ccaccttggc 23700 ttgcagcagc gttgctctag tctctgcctc cgtcgtcacg tggccttctc ctctgtgtgt 23760 ctgtgtctct gctttcatgt ggctttttta taaggacacc caccactggg tttggctttc 23820 ttataaggac acccatatgt ttccccacat atccaaaccg tatcagtatc ttggagcaag 23880 aaccaattgt catctctcag ttctgtggct ggctgggctc agcggggcag tttgtgctgg 23940 ggcctctggt gcagctgcaa ctgctgctgc cgtcacagga tcaagtggtg tcagctgcac 24000 tgagtggtga catgaacagc cacctggtct tcaggatgtg gacaatgaca gccttcccat 24060 tcacaggtgc cgtgcaccca tccgacatgc cctcatctat tatctaccag gtggggaggg 24120 gggcgtcccg aggggagggc actcaggtcc catggaagct tcctccctag gtttagtctc 24180 cgaggcctgc tcaggggctg gagattcagg tgtcactggg ggtgttctgg gctctgtcac 24240 gtcctatgga agtgagggct ctgctcgggc cctctgtctg gcccagggat gatccttcca 24300 gaagcccgtg gagctctgtg gctaatcatg gtgcagtgga caggctgggg agaccctgct 24360 aaactccagg gtatggaggc tgctgcggct gtggggcccc agtgtacttc agggttgcat 24420 cctgactgtt cttcatggtg aattgttttg tctgtttggt tcctggaagc agacccagag 24480 atgaggattt gagcaccaag agtttatttg ggaggtggtc ccaggatgca ctgtgggaga 24540 ttggggaagt ttgaggggaa gctgacaaag gtgcgttcgt aagtgggtga cctccgtggc 24600 cggggccctg gccttgccgg ggcccgtgga tgaacacaat gcacctaccg gttgtcctgc 24660 ccaggaaggc cagtgctttt ccaacaacgc tcgctgcatt agctgactgc agccctggcc 24720 ttttgtggtc ggagaaagtg ctcaggtggc aggacccttg cctttaagag ggaagcctca 24780 ggctgcgcag agctgtgagt ctggaaatgt gacctcaggt gggaaatgtg acctcaggtg 24840 cgaaccatgg ctctgggtgt gaccttcgac tccgggtggg aaccgtgacc tctggtgagc 24900 actgtggccc ggggtgggca gaggacgcct gttccacgct ccaacaggct ttgctgtgtc 24960 attgtaaggt gacccaggac atcagggagg gccctgtgaa tccccttcca tcccccactg 25020 ggtgccggca gcacaattgc cacctcagtc ttgcatgtgg ggtcatgggg aactccatgg 25080 ttggcacagt gacaagaacc agacccgtcg agcagctaaa gaccaccaga agcagagtgg 25140 atggaagaac aaagcctcag agatgggacc ctcctgcccc tgaaccttga gaatggccca 25200 gcctcaggcc agaccctaaa tgacagggtt aggcaggtgg gcgggttgga atgtgtgtcc 25260 cagaagtgac ggccagggtg ggcgagtggc acccttgcag cctccgacct gccccctggc 25320 tcagcctcca ggggcactgg gtaggcggcc tccccattat gcatttcccc tcataggatc 25380 cagaaacggg agggtacagc ctggaggtga gccagcgttg ccaagacctc gacactggca 25440 gcactgccca gctggtgaaa ggtggtctgg ctgaggctgc gccggcccag acccagagag 25500 ctgccagttc agagacagca gtgcaggcct ggacccgaga cctcatgccc cagtggtttt 25560 tgcctgcttc actctaccct ctcctctggc ctggagaaca aaagctgaac caaagcttta 25620 ccccacggct taggagccag aggccggagc catatctgtg ggcagccacg tttcctttag 25680 ccagtgggat tgaaacctga agcgagacac cctgcttcaa atgcctggat cccgtctggc 25740 cctgaagaca ttggagttct gggatttcgc ctatgtgcca gcagcctctg ctccccagta 25800 agctctgagc agaagtctag gcaagcccag gaggtcagga gggaaatgca ggagccccta 25860 cacttttttt gggcaactgg taggtcctga aggaacctcc ccttctcaaa gatgaacata 25920 tgcaagacac caacctcttc tgagatgccg atcttccggg gatcaccaaa ctaaattaaa 25980 tgtctgtggg gttacagcaa agttctgaaa ccaaggagga ggaaagggcc gtggactcag 26040 ggtaggggtg gagagcctgc cagggcattt cctccaggac acctggaatg tttcagacat 26100 tgtcactttc atcctcggga aactgaagag ccacagagcc caaacaacac atgagatcag 26160 tgtcctgccc actgtagccg aagacgcacc aagaaagcca gggccccagg ttgccggcaa 26220 gcaaaaggca ggttgtgagg gtggcaggga caggcaccca ggccgcttgc tggggacggc 26280 ctggtgatgg atatgagacg tgtgaggccg acctcaccag gctgcttgcg tgaaatgcaa 26340 cgaaggttat ccagcaagtg gtcaaaggtg tgcgtttgaa acgttcacct tggtgctgtt 26400 ttaccaagcc cggggcaacc gcccaaatgc ccgccagctg ggagctgctg aagggatgtt 26460 aagtctatcc cggcagcgga cctgagtgct cctgaaagtt tgtgtttaca gctgtgagaa 26520 agtgccacac gatgttgtgg ggaagggggc aaaggtcagc acggagccca agagtgaggc 26580 cgtgtgtggg taaagggcag atgggcactc actgcaggtc ctgtgtgcac tggatgtgca 26640 cgtgcatggg agacagcagg gtgcggggga gggaaaagag tggccgaaga atgaataatc 26700 aggaaaaatc tctaggaaag ctgttttcat tttggagaaa gcaaaccagt ggtggttttg 26760 gaagaaagtg ctggaagcta tgtcagaaat ctgagtgaag ggctgaggga gctcaggaga 26820 gaaggatgtc ccctaggcct ggcgcaggga agcctgacgg aggaaggggg tcatgggctt 26880 ttctcctgga ggttgagggg ccagggtgtt ccagagggct gacctgcccc cagacaagcc 26940 ccaggaggac actgcagaca gggcatgaga gggtgcgggt ggatgtccac ctgccaggag 27000 cactcacagg agccaccgtc cctggtgact tctcagctgc agctcagatc aatagaattg 27060 ggagtggctg ccctggctgg tgtgccaggc ccctcggaag atggcgggga ctgtgcgggg 27120 cccctcagag gatgtcgtgg ggaagtgacc tggccagcct gccctgcctg tccggtgaag 27180 ctgctgactg ttcctggagt ctcaaaacat gaggagaggc cccactctct aaagcgtgcc 27240 ttgtagctcc gctgtgacgc agaaattgga agcatttgaa agtaaattta actgttatcc 27300 cgtaatcatc acctgcataa ataatcctct tcatttgaac acaccagacc tagcagtttt 27360 gtgagccagc tgagctgtcc attaggtgca cttcggtccg acctggcaga gctagtgtag 27420 gttggcctgg gggcagaagt tgagtgtgag tgcttccgtc ctcctcctct ctcctcacat 27480 tctctgccct gaggaccgga ggacgtgagg gccctgagcc tgcccagcca ttctgcagat 27540 gctggaggct ggctggggac gcggaccctc agccatgtgc ggcccctgaa gtgagttcct 27600 ggagtgaggg gcctggctgt gctcatgact tactcgctgt gtgacactgg ctagagggca 27660 tccctttggg cctcagtttc cccacctgtg cagtagtgag gggtggtgct gggtactccc 27720 tgaggtcccc aatcatatct gcactcttct ggccatgcag aggaggccca gggtttgggt 27780 ggcctctcat ctctgccctt gcccacagat ggggatctgg acccagggtg ggtgcgaccc 27840 aggcccccag cctccgctgt gggctccccc aatcccgagc agtcggggac ctgggcaagc 27900 ccctctgcac gggcagcagt agcacccgtg tggtccctgg ggctgctgtt acagagggct 27960 acatgctgaa tggcttcaaa tgacagaaat gtcccccccc tgttctggag gccagactcg 28020 gaggtccagg tgcgctgcag agtgggcgtc ttaaacagca tatgttccct tctccgcagt 28080 ctggaggcgg aagtccaatc aagatgccca caggtctaga tcgtgggagg gctgtcttcc 28140 cagcctgcag ctgctgcctt cctgctgtgt ccttgcctgg cccagggagc tcgggtccct 28200 tcccctcctt taaagccact catcccacca tgaggtccct gacttcgtgg cttcgtctca 28260 tcctcatcac ttcacaaggc cccatttcca aatgccagct ggttgggggt cagggcattg 28320 catatgaatc tggggacacg ctcggcccac agcaggctcc gttgggaaga gccagctcag 28380 ctcggccctc acacctggtg ctcaaggccg caggaaagct gagactctga gaaaacggct 28440 gtattccatt cctttcccgt cccccttctt ccagctcccc ccactcctca ccccaaccct 28500 ccccccgctg tctctgtcgt ctcggtgtcc agtcctttgc aggcccatgc agagtcctgg 28560 gaaggctgcc tgatactggg cacctcgccg gccttggagg ggcccagctc tgggggcctg 28620 gccagagcct ggggtgggag gggatggggg ccctaaaggg gctggctgag gagcccagcc 28680 cagcaggccc tgggaggacc tgtttctccc tcctccctcc tcaaacctgc acaaggaaaa 28740 aattccagac cctggcaaaa aaagcccttt ctccagcaga atcggggagg tctctgtgag 28800 aagcaggctg ctgaaggagg ggctgcctgt ctccacaggc ctggcggacc tcagggctgg 28860 gaggtgttgc ggggaccctg gcttctagtc tggctgtgcg tcgtgtgacc gggggagagg 28920 acctcccctc tctggagctt ggggcccatc tgtagtgaca gaggatggtt cccagccaca 28980 gcacagggtg tgggaggggt ggcagggcca gggtggggtg gggctcccag acacaataca 29040 tggcctggga gtggggttgc cggcagggta gggtgggggt cccagcccca gtgcagggcc 29100 tgggatgggg gtgtaggcag ggccagggtg ggatgggggt cccagccaca acacaggcct 29160 gggaggggtg ggggcccagg acaagcaggc ctgagggatt ctcccaaggg ccatttacag 29220 ctgcaactga gccccactcc cgcccactca cctgtgctgc cctctgtccc ccacctacct 29280 ggcattcctt gggcaccatc tgtgccctgt cccagagggc ccccacctca tggagctcat 29340 ggcccatgtg gggtgtggca tcagggcttc atctgagcaa ggttggcacc tagggctggg 29400 caagggtggg acagggagca agggctagtg ggggtgtggg gatgggggcc aggcctgtgc 29460 ggggagcccg acctgagtgc agcggggtga ggcgaggggg tggatggggc aggaaggggt 29520 gtggggatgg ggccaggcct gtgcggggag cccgacctga gtgcagccgg gtgaggcgag 29580 ggggtggatg gggcaggaag gggtgtgggg atggggccag agtgcggcgg agtgagggga 29640 tgaggtggac acggtgggtg ttgctggctt gagcaagggg ccccaggcct ctgtgtcaga 29700 gctgggaggc ccagccgggc tgtgctaggg aaggcgctgc aattgtttcc acagcgctgg 29760 ttgatcgtgc tagggttctg gaggcggcgc cacgggtgct gttgggtccc ggcaggcgct 29820 gaagtcggga cagcttggcc ttctctctgc ctctgctcct ggccatagca cggacgtggc 29880 ccctctcacc tccgaggaca gggctgtgat ggtcagtccc cagctccctc ctgctggctg 29940 cccggggtgc ctgggtgttt cccagaaatc ctcaggcctg ggatgggggc gcaggtggga 30000 cctgaaactg gatctgccct ggcgacaagg ctgccagtga tgcctgtgct gtcagcaaga 30060 cgcttggcca gagggggtct cagtgccctg aactgccata aggaagcacc gcaaacagaa 30120 gtgtgctgtc tcgtgattct ggaggccaga agtctgagat caaggtggtg gcagaggtgg 30180 ctgctcctga gccatgaggg gcacctgtcc aggccctcca gcttctgggg cttgccggct 30240 gcttctggtg ttcctagctt gtcatcaccc tgatctctgc cctcatgttc tcatggcacc 30300 ctccctgtct ccaaatctcc tcttttataa ggacatggca gcactagatt agggcccgtc 30360 ttcatggagt aggacctcat cttaactaat tacatctgca gcaactttat ctccaaatga 30420 ggtcccattc tgagatactg ggggtaaagg cttcaaaata tgaaattagg gggacacagt 30480 ttaactcgta actggggcat tttgttctcc gtggtcctgg tggcaggtcc ccagggtgca 30540 tgctggcacg gagggtgcgg gcatactgga ggctgtgccg ctggccccca gcccacgctg 30600 gctgaggaaa accaatccgg ggcagacaca gcctcatctc cagccttcat ctccaagcat 30660 aggacggtgc catgagggct tcgttcttca ggtttgctga tgtgatggtg gtggtctccg 30720 ggggctccct gaccaggaat ggccagtgtt cctcctgggt gtgagaacct gggaggggac 30780 tgcctcaggc ctccaggcct ctgtcaacac caattctggg ttcagacagt gttccagggg 30840 gcagcgggtc ctgtccttcc ggccactgag gacatgcagt ctgcagggtc caggcccgtc 30900 cagggcctgg gaaatgctgg gggcaaggat ggaaggtggc agtgggtgtg ctgggtccct 30960 gagatacttg caggctgtgt gggtgggagg agctcctggg acactcatac tgggacagct 31020 cctgggaaac ccccccaggc accggctgtg ggcgggggca tcatcacgtg ttcatggatt 31080 tgttctgggt ttgaggaaca gatattctgt gagcactgcc tgaagccagc ccagggtgcc 31140 tgggactggg cttgaagttg ggtggaggag ggagggggag gagggactct ggcagaagac 31200 agtcccatag agctctgtct ggagtagcaa gcctagaaga accgcacagg cgtaacacaa 31260 acgtgatgga cgcccaggct tccagcgctt ctcgggcacg tgcacgctga gccggagcat 31320 aaaggcctga gcagggggcg gggcagggca ggggctgtga gcccaaggtg gacaccagag 31380 atggaggggc cgcagcttgc aggtgggaag gatcctcccc gggtggctgc ctttgagggg 31440 agccagttgc atttggcggg agaatgacac agagccttgc aggctggtat ggtggtaccc 31500 ttggacatcc atgggtggca gcgtccacca taaggagggg gcagagacag ctcatctgcc 31560 tgggagtggg gtcctaggtc ccctccaatt tgggggcctg gcttgtctgg ggcccgaggc 31620 ctcttaagac catctcccca ccttggagtg tagatgccag ctagtcaggg gccctcccag 31680 cacagcgcta accacctgtg ttccctccca cagccattgt taaccccaaa cagcccaagg 31740 agacgcccaa aagcttcagc tttgactact cctactggtc gcacacctca gtaagccggg 31800 accccgggtc gggggaggcg ggggcagcag tgcataggcc atgtggccct cggggtccct 31860 caacttctct gagccgctca ttcctctcta actggggcga ggaccccacc ctgctcccct 31920 ggaaggtcac cctgagcggt cctcagcgaa ggcagtgatg gaggctgcag gaactgaggg 31980 gccttcagct ccgtgtgggt agtttccagg gtcagagctg tgtgtacgtc catctgctgg 32040 tgacttttcc cccagacatc ccaaagtcag aatgcccaaa gctgaccctg agcctgtctg 32100 gaagctgtgc cctgcatgct gggagcccag gagacccctg gactcttctc cttccctcct 32160 ccccgatcca gtccacactg agccctgtct tccacctgcc acctcctgga cccttctaga 32220 agaaggcatg cagcctcctc atctaagccc ctcatatcta tatctctgag cacctgcccc 32280 ccataacagc cccagggctc cccgcttctg ccttccccat ccagtccttc ctccttccag 32340 gatgaccccc agctaatcac cctgtccccc tgcctaaagt gccccactgt cctcaggaca 32400 gtgtccaggc gctgtagccc agcctgtggg gtctctgggc ctttgcaccc tgtccccagt 32460 ctcagctctt gtcacccctg cttgtcacgg tcacatggaa cttactttgg ctttgaggtc 32520 tcacctctgg gcctttcaca tgctgttccc tctgctggaa cccgtcctgc ctcctgcctg 32580 gctggccgct cttcatcccg catctgtgac acagagggct tctcctccag gaagctaccc 32640 cacaaggcag gagtaggatg gggggcaggc atccctcccc actgtgctgc cctggcaccc 32700 tgaggccctg ggcatcccct ggctccgcag acatgatggg ctgagcctcg gatgcaccca 32760 gcctcctgca acttcattcc ttcctcgtcc tccagcctga ggacatcaac tacgcgtcgc 32820 agaagcaggt gtaccgggac atcggcgagg agatgctgca gcatgccttt gagggataca 32880 acgtgtgcat cttcgcctat gggcagacgg gtgccggcaa gtcctacacc atgatgggca 32940 agcaggagaa ggaccagcag ggcatcatcc cacaggcacg aagcgggggg cgggcggggg 33000 cagccctggc agatggggcg ggaccagctg aggctgagag ctccgggcca ggcacccctg 33060 agagcagccc ccagagagca gggagtcagg aggggaaggc cagctgggtc aagagtgggg 33120 ctggggcagg tgagagccag atgtggctgt gaagctgcag acccaggccc caggtgcagg 33180 aagggccctg gccttggaca gggtccacct tgatcatgtg cctaagacac agcagctggg 33240 agagccctgg ctggggcagc tgatctctga aggtgtgagg gctggcagtg tgggcagaga 33300 gaggtgctca ggacaggggt ggccaaacac cagacccagc agctcctcat ttgctgcagg 33360 aaccctgagt ccccagccat tcccctgggc aggtctctgg acgtgagttg gtcactagta 33420 ctttgcctgc tgagggaagg gagatggctg ggatgtctgt aggatggcag agccaggggg 33480 aggggcagat gacccacacc agccagggac ccctgagtta agagggagac actggctcct 33540 tggctacaga ctttctcagt gcctttacca tgacgtgtgt ggtgagggtg caagaggggc 33600 ctgagagggt ggatcccgcc tggcacaggc tgcccacagt atcgcaaggg gcagggatcc 33660 agggagcagc cccagccctc cctggctgac tgtcccccca ttcctgcagc tctgcgagga 33720 cctcttctct cggatcaacg acacgaccaa cgacaacatg tcctactccg tggaggtagg 33780 gctccccgcc tgccgttggc cgctggggca gggctgggaa tctggtgtgg ctggcagtgc 33840 ttttctgatg caaagtgagt gcccaccacg ggtctgcacg cccagcttgt ccctcactca 33900 tccaagtggc aggcaagacg gcgggcctgg gcagggctcg agacccccaa agcacagagt 33960 gatgaggtga tccccacctg gcaggtgctt ctccagcagc tgctctgtgc cagggcatgg 34020 gcaggtgcct cagagctcag ggcctggcca tgcctgccgt ggctggggtg gccctggcat 34080 gtgtgtgtcc tagagcccag gatggccgtg gtgagggagg ccacattgac acccctgcct 34140 cgaacataca cacaggggct gcagactggg agccctctgc tcagcaggca gcccccaccc 34200 tctcactcag gggtcctgat ggcagccccc accccctcac tcaggggtcc tgatggtggc 34260 ccctaccctc tcactcaggg gcccagcagg cagcccccac cccctcactc aggggtcctg 34320 atgctggctc ccatcccctc aggggtcctg gtggtggccc ccaccccctc actcaggggt 34380 cctgatggcg gcccccatct cctcactcag gggtccttat gttgacccct accccctcac 34440 tcaggggtcc ccccagtggc agccccactc cctcgcctca ggggcccctg atggcctggc 34500 tctgccctgc aggtcagcta catggagatt tactgtgagc gcgtccgtga cctcctgaac 34560 cccaagaaca agggcaacct tcgcgtgagg gagcacccac tgctggggcc ctacgtggag 34620 gacctctcca agctggctgt cacctcctac aatgacatcc aggacctcat ggactcaggg 34680 aacaaggcca ggtgggtgga gggactcact ggacctccct gccctcctgt cctgccgcct 34740 ctccccggag gaagcccctt cacctcggtc ctggcccttt ttggtagggt ccatctgtgc 34800 ccccgcggag gtgtggcctc ctgagcccga ggtcgtttag gcctgtgcca gcccgagaga 34860 ggccgagggc tccccctgtg caggggacac tgtcacctcc atggggcttc tccttcatgg 34920 gggtctgcgt cctccggctg aggtgcccgg ggggtgctgg cagcatctgt ggctgctgct 34980 tcgatggggc agctgctctg ctagtcccag gggtccacat tctgtgtggg ggccagtgtg 35040 ctggggtcag ggggcatgtg gggagggtcg gctgcagtgc tgcagccata agcaacctgg 35100 ctccttggcc tctgctgccc tgggcctcct gcctgggatg ccctggttgt catggcaaca 35160 gactccctct gccacccggg acttcctgag ggtgaggtga tggcccttgt cactctcagc 35220 tcctgaggtc gtgagtcaca ctctgcgcca tcctgcaccc ctttggtggc cccacaaggg 35280 ctggtgggtg ggggtgctgt tcctgatgag gcccacagcg caccctggcc gtcattgtga 35340 ctccgtgctg gaggtgggcc ctgggctgcc acatcccatg tgctgagtct tgggaacctt 35400 ccctgaggtc cctggcaggt cagggtggca tcaggaccaa ctccaggcca ccctcagcag 35460 ccttgggctt cctgttctgg aggaccctgc cgagacccat gccatctcct gaggggtgtg 35520 gcgggctcct tgggcttccc agagccgcgg gtgtgggccg tggtagggtg gacagtggac 35580 agccctttcc cccttcccct cccatatcat ggccctggag ggctcctgcc cagctgggca 35640 ctgcatgggc ttctctgtgc ccaggagtgg gaagctttcg cagtcactgc tgccctgaat 35700 ataccagcaa gggctggggc tgaggacgcc actgtgggca ggtggccatg ggccctgctg 35760 gagtcctggc aggaggcgcc atcagtgcca ggcccagcag ggcggcccct ggggtctggg 35820 ggaactgccc cccccgatga cctggttcag agggctggca ccaccggcga tctcgcaccc 35880 ggccacagga cgaggggtaa ccgtgcgtgg ctttctgctc ctcaggaccg tggcggccac 35940 caacatgaat gagaccagca gtcgctccca cgccgtcttc aacatcatct tcacccagaa 36000 gcgccatgac gcagagacca atatcaccac ggagaaggtg agtgagtggc ctcacaggcg 36060 gtgccaccaa gggcagtggc tggtggtcag ggtaggggtg gtggtcaggc cagtgggggc 36120 agcacaagga caggcccaat gctggcctgt gcagggcggg tagtgtcctc acacttacac 36180 tggcaccagg tgtggacgtc cccccccccg ccccagaggc ccttctccca tgccttggca 36240 ttctccatgg accaggccag ggggccatct tctggggctt ttgcctggac agccagtcca 36300 ggcttacggg aggggcagca ggagggcacc cagcctctcc ctgaccatct cttactctgt 36360 cccctgccct catgccccag ctgtccaggc ccaggggcac ctcagccacc acctggttgg 36420 gggctcgctc aggcagccgt gtggggagcg caaaggggct gggtggagtg agggctgctc 36480 agtccctgat ggtgctggag gtccgccagg cacatcctcc tgaccgggac tccatgaaac 36540 agtgagcggg ggctcaggat ggctgaggtg ggttggggga cagacgaggg tgaagctgga 36600 cgaggtcggc gcggctgcct gccccgctgc cctcactggt gggcaccgag agggtcctgt 36660 ggtgtccgtg ggcaagtcct gccctgtagc tatggctcag gaggggccag gcctcccggt 36720 gcagggcctc ccaccccaga ctgcgggtgc ccctgttggg agcctggccg gtgcccacct 36780 cgctaggtgc agccatggcc cgtgtggtgg ctgagcaggg ccagggcctc ctggagctgg 36840 gttctaatcc aaccacggac actgagcacc atctatggaa gtggggacag tgacagtcgc 36900 acctcgtgga tgccataggg agcgagtacg cccttgtgtg aaaaccaccc agcgtgtggt 36960 ggcagcgccc gtgctcccct ggggaggtgg ctgggcactc aactcgggca gggccttggg 37020 agagctggga cggaggtgcg ggtggaaact gcggggtcag gactgctggg cctggggagg 37080 ggcggcgcct tgcagagggg acgcttggcc agggctcctt caacagctgt ggagaccttg 37140 cccaggggtc ctgggatgcc cccgcgcatc ttgtggcctt tcctgcatgt gatgtatcta 37200 ctgtttcagg tgagcaaaat cagcctggtg gacctggctg ggagcgagcg ggctgactcc 37260 acgggagcca agggcacgcg cctcaaggta ggggccaggc cgccatgcgg ggacccgtgt 37320 ccacatttgg cctgctccag agtgggtggc aggagggctc tgttggggtc ccgggggcct 37380 gggccaccct gagggtgagc ctgcataggg agggtgggca taggctgggg tcttgggctg 37440 ccagcagccg agggccatgc ccggggcacc agcgctgggc acacaggtca ggggtttggc 37500 gggacggtgt cctctttcgg gccccaagga ccttgcgccc agaggccagg tcttccctgg 37560 ggagattggg gcaccacccg ggaagcagtg ccggggtcgg gaaggagtgt gtttcctcga 37620 cccctgctgg cctcagcact agatgcttgg gcaggggacc cggaagcatt tcagggggac 37680 atgggatgat atcagggttt gcatggggct gagggcaaca ctgggggaca tgctcctggc 37740 cagaggctcc agctggcttt ctgccagggc accccacgcc caagtggccc cagagatcag 37800 cagctgcagt ggtggcctcc actccacact gcacaggtcc acccagggca tccctccaga 37860 gcaggaggcc ccacgggtcc ccagcatccc aaccccactg tcttttctgc ccgcaggagg 37920 gggccaacat caacaagtcg ctgaccaccc tgggcaaggt catctccgcc ctggctgaaa 37980 tggtgagtgg cccggcccgg cttccatagc cagaacccca gagggtcttt ggcgccccat 38040 cctgcccctg tcaccctcgt ttccgggccc tgtgtctggg aggtggccag gttcaaggga 38100 gagcccggag atggccagag tgtcacatgc tggagaaggg gtaggggccc tggtttctcc 38160 cgggaccctc agtttccccg cctgtaaagt ggggctatgg ccacagttgg ccccgtgcag 38220 caggcagccc aggcctgggc ccgggaaggg cggccctgga gggaccctgc ctgggggagc 38280 tgctgtctag gagaccacgg ggtggtagag cctgagtcat ggccagggcg aggcagccgg 38340 gccgcctgct cttccgcccc cacagcccgc gccagcttcg ctccgggcct cagcctctct 38400 ctgtcttttc cttttcagga ctccggaccc aacaaggtaa gcggcttcct tcagccccgg 38460 ggcaggtgcg ggaggctggt ggcggtgtct gccctgcatt ggcgccctgt ggtgaggggc 38520 ggggcgggca gtgagtgcgc tgggagatgg gggacgtggg ggtggatccc gggaaggaag 38580 aaagcgggtg tgggaggccc cgtgcggtgc ctgtgcctgc ggggacggag ggcgtccggg 38640 gcggcctcac ggcagggcct ggggcggggg ctgctgggag acaccgaggt gggaaagtgt 38700 ggcccggggg gcgtgggggc cctgggagga gctgaaaggg gcgcggagga gcccctcgga 38760 catggagagg gctggggagc cctgagagga agcgggtgac aggcgtgctg gactctgagc 38820 agccgtaggc gtgacggggc cacaggggga ggcgggcgcg tgtggagtcg gaggtgccgc 38880 ggagcgcgcc acgtgtgaag ctgcctgggg cgacgctggg gactgtgtga ggaaccgcgt 38940 gggcagccgt gaaagcgttc gagggaccgg caggaacgga gtgagccagc gtgggaatgc 39000 gtgagacagg gcgggcgcca ccacggggat ccgcgaggtg ctcactggga aacgcacagg 39060 gaactcggcg gtggctgtgt ggggacagag aactgtgtga attgtgaaga gctgtgcggc 39120 ccgtgtgagg agttccaaga gactaagaac acgtggggct gcaggaagaa ctgggagaag 39180 gcgtgtggac tgagtgggga actgtggaga acggtgtggc gaacccgagt gggagccagg 39240 cgaggaagct gagggcccct gtggggaact gtgtggggaa ctgtgtggga acgggagagg 39300 aagcgtgtgg gaaacggcac aggacactgc gtgggactgc gggagacgga ggacctgcgt 39360 ggggaattgt gtgtggagcg gagtgaactg tgaggagcgg tgataaccgc gtggaactgt 39420 cagagaacgc tggggaatgg cgtgggcggc gtggggagga agcggagaac gatccgctgt 39480 ccagattgtg cgggactgtg aggagctgtg tgtgtgtgtg tggagctgtg tgtggagctg 39540 tgtgtgtgtg tgtgtgtgtg tggagctgtg tgtgtgtgtg tgtgtgtgtg tgtggagctg 39600 tgtgtgtgtg tgtggagctg tgtgtgtgtg tggagctgtg tgtgtgtgtg gggagctgtg 39660 tgtgtgtgtg gagctgtgtg tgtgtgtgga gctgtgtgtg tgtgtggagc tgtgtgtgtg 39720 tggagctgtg tgtgtgtgta gctgtgtgtg tgtgtgtgga gctgtgtgtg tgtgtggagc 39780 tgtgtgtgtg tgtgtggagc tgtgtgtgtg tgtggagctg tgtgtgtgtg tgtgtgtgtg 39840 gggagctgtg tgtgtgtgtg tggagctgtg tgtgtgtgtg gagctgtgtg tgtgtgtgtg 39900 gagctgtgtg tgtgtgtgga gctgtgtgtg tgtgtgtaga gctgtgtgtg tgtgtggagc 39960 tgtgtgtgtg tgtgtgtgtg tgtgtgagct gtgtgtgtgt gtgtgtagag ctgtgtgtgt 40020 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtggagct gtgtgtgtgt ggcgctgtgt 40080 gtgtgtgtgt gtgtgtgtgg agctgtgtgt gtgtgtgtgt ggagctgtgt gtgtgtgtgt 40140 ggagctgtgt gtgtgtggag ctgtgtgtgt gtgtgtggag ctgtgtgtgt gtgtggagct 40200 gtgtgtgtgt gtgtgtgtgt gtgtgtggag ctgtgtgtgt gtgtgtgtgt gtgtggagct 40260 gtgtggggag cctgcagaga actgtgtgtc caactctgtc agaagccgga agaacctgtg 40320 tgaggaccag aggaataaat gcctcaggaa ccgtggtggg aacccgagga actctggggg 40380 cctgagggta gctgcgtggg aacatgagct gtgcgtggtg ccgggacagg acgtgtgtgc 40440 cacagggtgg ggagctacgt ggaatcatgt gagggaaccg tgcagagctc tctgtgcagc 40500 tacgggaaag tatgtgagaa accgtgtgag gaattgcgtg gggaactgtg ggaggatttg 40560 tgagaaactg aatgtgactg tgtggagaag gcggggaagc aggcgggaag tgtgtgggga 40620 atcgcttggg gaaagtgtgc gctcgtgtgg ggaaccacat gggggctctg tggagctgga 40680 gctccgcgta ctctgaggac ctgtggaaat gggagcggaa gtgtgtggag gggtgtgggg 40740 ccgcgtggga atcgtgtgag ggacgccgag gagccatgca gctgctcggg gagcggtgct 40800 gggctgggag aaactgcggg gggccaggcg ggtggctgct gggaaaggca tgaggaaccg 40860 tgtgaacgct gcgtcaggga ctcgggggat ctgtggaaat gtggaggaca ctgtggggaa 40920 gcgtgcggga actcggagga actcgcgggg gcctgagagg agccacgtga gcccccgtct 40980 gaggcactgt gagaggatct gcttgagaaa ctgtttgtgg aactgtgaaa ctgtgaaagt 41040 gggtgcaacg gggctgtgtg gacctgtgtg gaatgctgtg gagagctgtt tgaaaacgga 41100 agcaccgtgg ggcgtgggga ggcctggggg gaaacatggg acagcctgcg tgtggagcca 41160 tgtgggaaac aacaactggg aggcagtgca tgcggctgcg tgaggagccg cagaaccgtg 41220 cgaggaagcg tgtcagccag tgtggggaag tgtgggaact gtggggaact atgaggaact 41280 gagtgtggaa ctgtgaggaa ctgagtgagg aactgtgagg aactgagtga ggaagtgagt 41340 gtggaactgt gaggaactga gtgtggaact gtgaggaagt gagtgaggaa ctgagtgtgg 41400 aactgagtga ggaactgtga ggaactgagt gtggaactga gtgaggaact gaggaactga 41460 gtgaggaact gagtggaact atgaggaact gagtgtggaa ctgtgaggaa ctgagtgtgg 41520 aactgagtgt ggaactgagt gaggaactga gtgaggaact gagtgtggaa ctatgaggag 41580 ctgagtgagg aagtgagtga ggacctgagt gtggaacgat gaggaactga gtgtggaact 41640 atgaggaact gagtgaggaa ctgagtgagg aactgagtgt ggaactatga ggaactgagt 41700 gaggaagtga gtgaggaact gagtgtggaa ctatgaggaa ctgagtgagg aagtgagtga 41760 ggaactgagt gtggaactga gtgagggact gagtgtggaa ctgagtgtgg aactgtgagg 41820 aactgagtgt ggaactgagt gagggactga gtgtggaact gagtgtggaa ctgtgtggaa 41880 ctgtgaggaa ctgagtgtgg aactatgagg aactgagtga ggaagtgagt gaggaactga 41940 gtgtggaact gtgaggaact gagtgtggaa ctgagtgagg gactgagtgt ggaactgagt 42000 gtggaactgt gtggaactgg gtgggaacat ggaggtgctg ttggggaccc gtgaggagcc 42060 gtgtggagcg ctgtgtgtag gaacggggtg cacacgggcg aatggcctga ggaagtgtgt 42120 ggaaagtgtg tgtgcacccg cattggggat ggcgtgaagg gttgtgtgag gaacgtgtga 42180 ggaagtgtgt gagccatggc gggaggagct gtttgggaaa cgtggggagc ggtgaggaac 42240 cgtgtgtgga acggtgcgca gaatcgtgag gaaagctgca gagacgtgtg cgaggggttg 42300 tcggggagtg tgaggagctg gatgggaagc tgcggggacc tgctgggcgc cgcgtggagc 42360 tgtgggaacc gggaggaagt gtgtggaagg gggtggggag ctgtgtgggg acgggggccg 42420 agctgaaggg gttttcggga gctgcgtggc tgctgtgagg cccgtgggac actgagaagc 42480 ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtaacgct gtgcgggagc tgcgagcgcc 42540 tgctgagagc tctgagaaat ggaggatcgt gtgaggcctc ccgtggggag ccgtgttagg 42600 aaatgttgga ggaatgtggg caagtttctc tggagctgtg aggaaccgtg agagcgagtg 42660 tgtcagggac ggtggggact ggcgtgtgga gaatggtgag gaacgcctgt gtaacgaggc 42720 cctatgtaga gacctaggtg aggatcgcgt ggaactgtgt aaagaactcc acagagaact 42780 gtgacagaat tgcgtgtgga acttgtgggg aaacttgatg aatggtgtga ccggcagcca 42840 tcccgtgggt ggggtccgca ttcgagtgac tgccgttttc ctgaatggag gaataaaggg 42900 ggaagcagga ggagctgcgt gaagaaccgt gtggagaaac gcgaggaagt gcgtggggag 42960 cgggaggagc tgaggaactg tgtggtgagc tgcgagcagc cgcgtgggaa ccgtgcgggg 43020 aacggcgaga gctccttgag ggactgagtg cttgagcgtg cgggactgac atgtggaagc 43080 accgcgtggg aaccgcgtga ctgtctgtgt gagggactgg gagggaaagt gcgagggacc 43140 ctgcgaggga cagtgacaga gacttttgaa ggagccgcgc gagagggttt tcgaggaact 43200 ggttgaggag ccaggcccag agcagggagg cgaggccggc aggagccggg cccgtctgag 43260 gatccgaggt ccctcccggc ttgtcaggag ctgcctgggg gagctttagt ggcagcagcg 43320 ggcgggtgtt cagcggggct cacagtgtct gctttagcca agggtgcgtc ctcaggccat 43380 gtgcgctggt gacggatagg tcgggagcag gtggcctggt gcggcaagtc aggatggaag 43440 gtcagcgttc caggcttggg atggtggagg ctggggggcc tagacgggag agcggggtgg 43500 tcctgggaga tggcagagca cgactggaca gggaggcggt gagggagcag gaaacccagg 43560 gggctgctgg gctccttgct gaagtggctg aatggctgga ggacatttat gtggaagcaa 43620 ggaatgtgac acatagcaga gaattcaccc tcaggaatta aataatcaaa aaccaaacta 43680 gaggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggagccc gaggtgggtg 43740 gatcacgagg tcaagagatc gagaccatcc tggccaacgt ggtgaaaccc tgtctctact 43800 ttaaaaatac aaaaattagc caggcatggt ggcacacgcc tgtagtccta gctactcagg 43860 aggctgaggc atgagaatcg cttgaacccg ggaggcggag gttgcagtga gccgcgatcg 43920 tgccactgca ctccagcctg gtgacagagg gagactctgt ctcaaaaaac aaaaacaaaa 43980 acaaaacaaa agaaaaacta gaaatagagt agagttagtc cctactaagt ttccaaagaa 44040 aaaagaaagc agtcagttat gctgctgagc tgcgagatgg acaccctgaa accctgctcg 44100 cagagaagcc agtgcagtat tctggacccc ctttgactgg gagtctcaag agctttcaaa 44160 ttttatgtgc cttgtgagct ggtggagctt ctcctggggt tgtcttcaag aacaatgatg 44220 tctgtgtgtg ctcccagccc ttgaggtggc atctgcgtgc atgtcctggg gtgcaggctc 44280 cagggtcaga ggcctcatct gccggcccag caggtgctct ggaaatgctt cataagccaa 44340 tgcatacatg aaccagtaga cattggaagt cactgaaacc cacagttagt gggatcatta 44400 agtcagtcac agagtgtctg tcagaagcaa ttcctggcag gcattatgtg gatggagtcc 44460 atattttaaa gagccaaaga ggcagcaaga gcatggagga tgcttcattc tgaggggagg 44520 gatgggagaa caggccgtta gaggaaagct tgtgagctgg cttctgcagg accataggga 44580 gtttgatggg ggagagggcg ggtgaactct gggtgaaggg gagatttaag ctggcaggga 44640 ggtaagcgtg gcagaggcca taggggcctg gagggccaca tttagctgtg gggccttttc 44700 ccttgggtca ggagtcgctg atggtgttcg aggaggggcc atggactcag atgagtcctt 44760 cagacagagt ggagggagga cacacttgct ggtgacatca gcactcctgg ccggtgtcca 44820 gctgggtggc ccaggggcag cagggatgga agagggagga acctgaagga catgctagca 44880 agtccctgac tgtggcctag aggaggcctc tggggtggcg gcctggggtc tgggcaggga 44940 gaggcctggg cagcctgaga atgtgtccag cagagcgggc cccgcccctt gcccagcctc 45000 cagctttgag gacccacttg gcagggcctg cgctggcccc tccctttcgc ttcctctgca 45060 gtgggctcgg gcttgacctt gaatgttcct cccccacaga acaagaaaaa gaagaagaca 45120 gatttcattc cgtaccgaga ttccgtgttg acctggctcc tccgggaaaa cctgggtgag 45180 aacttgtggg tttgcctgtc cccagggctc tgatcccacc ctgggctgtg cccttcttcc 45240 ccactgaggg ggtgcccagt cgccagcagg cctctcaccc tttctgggct gaggctggga 45300 ggtgaacctg gagggtccag tcagttcgtg gcccttctgg aggacctggg gcaacggcca 45360 gcagtgggtt aacgaagcga gtgtgggaac caggacagcc cagggggtgg cacagcacac 45420 acctgcctgt gtcagtggtc ctgggtcagg tgggctgtga cacccaggcc aagtactcat 45480 ccttctctgg gccttggttt ccccatcagt cacggggacc tgggacgcga tctgggagct 45540 ctgcttgctg gattttgagg ggctgccata aacctcctct tctccgtctg agttctgagc 45600 agtgagactt agacggggag gtgggaattg aaatgcaccc gacgctgatc ccgtccatcc 45660 cggaataacc tcagagtcct ccccaactgc atttacagct ggagaggctg atgcccaggg 45720 aggtaaactg agtcttgggc tgacctggtg aacatagatg actgggggtc cctggcctcc 45780 ctcagccgca tggctgaggt gtgcagagcc ctggctgacc acctctgcac cccacaacta 45840 gccatgcttg ctccccagct caggtcagta ttgcagaccg cagcaggcct gcggatggat 45900 gggccccgct gagagaggag gagagtgtgt tccttcacct gagacgtggg ctgggaagga 45960 gccgcctgct ccaggcacac ccaggttcag tcccagggcg ggggcagggg agtcctccca 46020 cagaggcttt cctggggccc gtgtggtatg tgcccagccc ttcacaccgt ctcttcagtc 46080 cctatgggga cccactgggg acccatgccc tggggacatg gccctgagga tacacagttc 46140 cctggggtca agcaggcaag atcatctgtc cagacttgaa gcaccgccag gcagcagtcc 46200 tgagggctgg cgtggagtca gtggtgatct tttccgatgg ctgaggttac ctagacagga 46260 ttccctcaag agaaagaaca cagtctgttc ctcatgccac gcattacctg atgctttgat 46320 cctactaacc tgggccagga atctgatgtt aaatactgag gaatatattt caaatgaaaa 46380 tgatagaagt gcttgaaaaa aatattgaac ataaatggta tttattttgg agtaaatact 46440 ttaaaaccct ccacaacttt cctctctgct ttggggaaag gaaggcctga tggttgtaaa 46500 atggccccaa atgtgagaaa aacacaagta aaagagaaat aatagcggtg cctggttcag 46560 agatgaagga gcagccaagg aaggccaggt ccttgctgtt gtctgtgttc atggggtggg 46620 ggtggggggg ggggtaagcc tgtgactcag tttacctctc tgggcctcag cctccccatc 46680 tgtaaatgtg gggggaaggg gggagcagac atagccctgg ggcctagatc cccctctggg 46740 cacaacctgg tcttcttccc acaggcggta actcaaggac agctatggtg gcagccttga 46800 gtcctgcaga catcaactac gatgagaccc ttagcacgct gaggtgagtt ctccagggag 46860 acaagctctg cttcccgctc cctggtcttg ggggatggat cctctcgtgc ttgaattagg 46920 aagcaccagt gaccaggggc gactctttgt gaggggtata ccctggactc tgtgaggctg 46980 gaagagactg ttctgaggct cctgggcctg cataggccct gttctattcc ctccatggag 47040 cctttggggg tgtgctttgg ggctgcaggc agcccagggc cccgtggcac cagactggga 47100 gagctgtgcc tgctgggcga agcagtttac actcacctgc cggccggggt aaccactggg 47160 gatttttaga tagcagaggg gacataggtg tgtcttatgg gcagggtggg cacctggggt 47220 ggggagcctg ggcccctagc catgctagag gctgctcggt tgtttgggtc agtggtctct 47280 cccttctttc gactgtgcac caccagtgct taagagaaac aaagggcgtg tggcccaata 47340 gaggttcatg tactagctgg aaacgtagac atgtgcatcg gctggtacac ggtgtgagca 47400 caagcctatg cacacataga tgtgctcaca ttttcccact ggactttctc cctctaccct 47460 gggaccactg ggggagagga caccaccctg tcccttctca cctgggcctc agtttcccca 47520 agtgggcgag cgggaactgg gtgacctccc ttgtaagtct tctctggcct gtggccccaa 47580 atgccctccc cagcgacttg ccatgggggc gatttctcac tctgtgccag gctgtgctgg 47640 ctcaggtcca cctttggcct ggctgctgag cccaaaaggc tgggtcttgg gcagggctct 47700 aggcaccctt gggacctgcc agatgtggac ctgtcccgag cacagcccac agccccctct 47760 gccacccagg tatgctgacc gggccaagca gatccgctgc aatgctgtca tcaatgagga 47820 ccccaacaac aagctgatcc gcgagctgaa ggatgaggtg acccggctgc gggaccttct 47880 gtacgcccag ggtcttggcg acatcactga cagtgagtgc ctgctccagc ctgtcctgga 47940 cagggttgtg gggcctcagg ctcaggggcc tcgcaggtca tcacatcctc tctcctgggg 48000 ccaccacttt gctggctgca ccctgggctg tggcagctcc acaccgctcc cagagcccct 48060 ctgggccaaa tccctgtccc tgctccacgt tcctgggcag aaatgcctct gggtgggagg 48120 ccgggcgggg gccctggaca agggcaagtt tcctggcctt ggcctggatg gtaccacatg 48180 gtttgggttc aatgctgatg caagtgggcc agagacggct cccctggaag ccccataggc 48240 aggctgtggg tgctggggtc accgaggtcc cccgcgttct ggagctgaag accttcacca 48300 ccctgcttgt ggccacacac ccactgctgg ccaccctggc ctgtgaaagg cgtgcctgac 48360 cctctggaga caaacctgtt cttctgtttc tctgtctctc cccctccccc acgcttccct 48420 cccccatagc caacactgtg cctggaggac ccaaatgtgt gtattccctt tgctgctctc 48480 tgcatctctg cttccagccc cagccagcat gagggcctag ggtggcatgg tcagggaggg 48540 gtgaacccca gggtacctgc tctgctttct tctccttttt ggggggcaga aagcactgct 48600 ctccctcagc cacagggccc tgctcgtaga tgtgggattc tgtctgcctc tgagcccaca 48660 ctcctggctc cttcccaccc atatggtcta catgagaaac caaagcaacg ggggagtcag 48720 ggtgtcgctg aggccttctc aggctaaaca tggccgagat caggtcctct gaccccctgt 48780 gcacccaaag gcctgcgaag gtcaggatat cagcaccaaa gggccaggag ggctggaggg 48840 actgtcctgt ccccagctct tggctcaggc ctccatctgc aatgccattt ctccagctga 48900 cctgaccccc cacgcccagg ccctcaactc tggaaatgcc agaagctcag ctttcacagc 48960 ggatactgcc aaatcccacc caacctttgt gcctcctggc ctcgggtctg gctccatggg 49020 gctcagtgcc tccccgagct tggctgcagg gcgccctcca cttcccccac accccgtgtg 49080 gtcccgtgct tgctgctgct ctgctgtgtg ttcgcttccg ctaggagacc cctggcacca 49140 cccacttcag agatgtcaca gccccacctc ccgggcctta gggatgcatg aggcctaggc 49200 tggtgggtga gctcctcgtg gtggagggga agggcctccc tcatgagggt cccatgttca 49260 cctcctccag gatggtctct gggccaattt ccatgtcagt gggctgaagg ttagcacagc 49320 ctggccccac agctcggggg tgtgtggtgt cccaggctga cggtggatgt gaggggtggg 49380 aggacaagcg tgggggtctg cacggggcgc tgctgggtga ccacgccaag ccagtggaca 49440 gggtgggaag atgcagggag gactggctcc cagccctcag gtgtgggggc tgtagggtgg 49500 cctggcagtg gggcctggag tgcagctgtg ggaaagcaag aagcctggcg cagggggtgc 49560 aggggagctc cagagtgcct aggtctgtgc catgctgctg ctggggaggg caggcctggg 49620 gggcaggcgg gcaagtgcgc gccactgctg gccccgtccc atcgtaggca aggggtggca 49680 ggaaggcctt gcatgcgctt gtcctgggcc tggcagggct gctgtgcctc gttgatggtt 49740 tctgtttctt gccttctctg ggccccatct cttacttttt cccatcttca tcttttttct 49800 ctccctccct ctgtctgtct gcccgcccta cccctcctcc ccatagacgt gtccgacctt 49860 gagaacaata accttaaccg tggcgggacg gtgaatgaag cccctgaccc tctctccaca 49920 gtgaccaatg ccctggtggg tatgagcccc tcatcctcgc tctcagccct gtccagccgc 49980 gcggcctccg tgtccagcct ccacgagcgc atcttgtttg ccccgggcag cgaggaggcc 50040 attgaaagac tgaaggtgag ggcaccacct ggggcttcag ggtgtcagac tctgggagtg 50100 gggagctcgg aggagttaga gaggcaccct gccctcctgg gtacagccca tcctcatagg 50160 gccattgtgg agcatcagca ggagcctctg gcgtgtggcc acccaggtgc ccagtggtct 50220 atctccagac cacccacagc agccaaggca gccagttcac ttgggggtcc ccaggctgtg 50280 ggctgcacaa cactcagctg ctgggcagga aatgcgcctg caggacccta gacctgggtg 50340 tctggatggc ctgtgcccct acccatgcca agcctggaca agggaagctc caagaatgaa 50400 tgtccaggac tgagactctt cctgtcgagt ctttaattgt gtgagtgggt gcttgttcaa 50460 ggagcagtga gctggatggc atctgtgggt ggagaggagt ctcgtccctc cccaccccgc 50520 agcatcccct ccactgacga cagtcccagg tcacagcagc ttcctccctg gcgtcctata 50580 gaattatacc ccctgagaag ggcagtgagt gtggtgcagg ttcctgagct ccctccaggc 50640 catcctgtgt tcacacctgc acacctgcct gggaatagtc accacctccc accgctcaaa 50700 ggcacagtgt gctccctggt gcccagcaat gggccgggat cattttaggt ttctagacac 50760 atgcccctca gtgaatggct gtgcaggggc aggtgagcca cacgcctgga gactgagggg 50820 ctgaggggaa aaggcagagg ccccactgag gctgttgtga ggaaggggat gggggcgagg 50880 ttgggcctgt gaccctggag cagagagccc ttctggggtg ttggggtccc actgggctgt 50940 gggtgggaag aaaaaggaga gaccaggctg atgttgggca gtgtcgtcca tgtcctgaag 51000 agggctgagc acctgggcct cttggcagca gcgaggatgg ctgtgcttta ggagccgagg 51060 ctcagaatct cccaggagca tttgcttctc ttttccttcc agatttgttt tgcgttttct 51120 ccattctcct gagtgtgtct aagggaaaga cagacattct ctgagcttta ccttggtctt 51180 ctggatgcct cgttgccttg tcgggcccag gaatatggcg cttgtgcttt gcagctcctt 51240 ctcctggcac ccgtgtctcc attgtcctct cccttggccc tagccccggc agctcactgt 51300 gctctgcctc aatccccagg aaacagagaa gatcatagct gagctcaatg agacctggga 51360 ggagaagctg cggcggacag aagccatccg gatggagagg tgtgcagcgg ggaaactgag 51420 gcccaggggg aggggtgcag ccagcaagcc cggagcctgg gcaggatgag cactgagccc 51480 tgccctccag tgctgggcac ctgcaccatg gggtggccac atcccagccc agggcaaacc 51540 tgttccctca tcgccaatga cccccacctt gtgtactgct ggctgctagc caccaaggcc 51600 tgagagacct gaggcctgat agacctgatc cctgaccatg gtgcagaggg gccagtccca 51660 tcagcagatg ccctaaccca gtgaccagat gggacacgca tgggcaccac ccaggccacg 51720 gtggccacag gcccgctgcc cccattggtc agccagggct gaggccagtg ctggaagcct 51780 tgtggagctt gtgctgacct cagctctgtt cccccaggga agccctgctg gccgagatgg 51840 gtgtggccat gagggaggat ggcggcacct tgggcgtatt ctctcccaaa aaggtaggag 51900 ctatctcagt tctgtggtac tgccctcatc tgaacaggac caggtgaggt gctgtctcag 51960 gtagagccag agggggctcc tggaagtagg ggagcacggt ggggctctgg cccaggcact 52020 ggggctgtga agctcaccca tagtcacact ttgctttttg tggagaattc tgtccccaca 52080 ttctcatggt ggggcatgct ggtggctttg ggacatcaga tgggtctctt agtggcctgg 52140 agtgtggact gggctctcca aggtcagagc aaggctgagg agccaacacc caggctggag 52200 actgagacac gaggggcctg gacctgccct ggagcctggg ctgctcacag agctgggtgc 52260 cagctgcctt cttggaactc agctagagtc aggtctgact gttccagtgg ggacccctct 52320 tttcccacca ggccaggcct aaggggtctt tcagctggag gccctcacat ggcacagaac 52380 ccctgggcag ctgcttcaga gtgtatatga ctcctgtgcc cccatccagc agcccaggtg 52440 gggcatggca cagcagccca ggtggggcat gacacacaca cttgggaaaa agtctttctt 52500 gtggttctag tccccaaccc ccacacaccc accccaaaga tggccaggac atggggacag 52560 acacctgtgt gtccatagct tgggaggggc tgggcagggc tgtgctccag gccgccggcc 52620 cagcacgcgc tgaggtccgg agacaggaag ggcctgagaa gagctgtagg gagattccag 52680 tcccaggcag ggccgggaca ggcagtgtcc taatggggct tcactataca cgtcttctag 52740 acaggccttt ggtttggtct ggaatggatt gttccctgca ctgtttcaga ccccatcccc 52800 ttcctggagg gatagggtgg aactccaggg gtgcagcttt attggttgcc ctgggtctgg 52860 gcactgccca gaagtgggac cactggggac ccccttcttg agaagttcag tgttcttggg 52920 aatcacgaga cgtgcacagg ccagtggggt cccaaggctg tagcccctac tcagccccaa 52980 agctgtgggc acagcccctc ctggctggac atcttcccca ctcagggggc agggacagct 53040 ggggatggtc tgtccccttc gtccagtgac gaggtctcca cctctctgca tgggggtgcc 53100 tcaggtggct catcaaggat cccttcacaa ctgcttcact ccccagactc cagggctgag 53160 ccctccatgg tcagtgtcct gatccttctt ggctcttggc tcccactggt gaacccatgg 53220 tttctgggct gtctgagctg gaatggggtc ctagaacccc attttacagt ccaaagctgg 53280 gaacccagga ccccatggga caaagcctgt ggtctgcaca tctgggggct caccccagcc 53340 tcagagggcc ccagggcccc cacatgctga gagctggggc tgtctgccct tctggaagct 53400 cagcttctgc tgcagtgctg gggctgctgt gccaggcttg ggtgtatgcg ggtggtcggg 53460 tcccaccggc ctgctgctgt tggtgggctg ggccttcggc ttgagctttc tgtgttcctc 53520 attttcctgg cttggagtga ccagcctggt ggcaccagcc aagtgcgggg gcagggaccc 53580 tggtggtagt ctggtgcctg gagagaggtt ggaggggggt gtggccagca tcaggctcct 53640 gcccctctgc aagagagatg atcctcctgt ctccctgcag acaccacacc tcgtcaacct 53700 gaacgaggac ccgctgatgt ctgagtgcct gctctactac atcaaggatg ggatcaccag 53760 gtgagagggg acctggcagc cactccagcc tggccaggcc ctgggatctg gcaggggaag 53820 gctggactcc ccattcctgc ttctgcagag gggccactga gtttggactt ccccagcgac 53880 cccactgatg tctgcgctgg gtgtttccca aacaatcctg gttgggcgtc cctggaggcc 53940 agtgggtggc gtcctgggtg tattgggtcc cagctgccgt gctgatggtg cccccacccc 54000 gcagagtggg cagggaggat ggcgagaggc ggcaggacat tgttctgagt gggcacttca 54060 tcaaggagga gcactgcgtc ttccggagcg actccagggg aggcagcgaa ggtatcacca 54120 ccctaccgtc cctacccgca cccatgcccc tgtgccgtga tgatcaggcc tgaatgaggt 54180 caccctctcc cagcttaccc agcactaagt gggtcgcgag tcatacttct aggcaggacg 54240 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgagag agagagagag agagagagag 54300 agatttggag agagagagag atatttgggg ccagccttaa aaacaacttc cattaggttg 54360 gtgcttggga aaatgcctgg tactttctgt ggccaggggt agctgctgcc ttagggagct 54420 gagcctcctt gagggctgga ggtgggggca caggtgggct gctggccggg aagcgtgttg 54480 gggcccaggg tggaggatgt tcatggcggg aggacagtga gccatgagga ttgagcccag 54540 atctagggtg gaaaactatt tccagacctt ggtttcctgt tggctgtggg cggccatctg 54600 tccgtttccc ctgcctgccc agtggtctcc ctcctggaga tgacgtgggg ctgtccccat 54660 tgcctggtgc tgcccaactt ggggatgggc ctgtggtgtc agtgtgccgt cacatggccc 54720 acagcccagg ctaagggcat ctcccggcag catccagcca gcctctggcc tgcagacctg 54780 tgactgacac ccactgtcca acttggccac ctcagggtga tggccctaag tggtgttggg 54840 acgattggct ctcctggaat tctctgactg caaagccctg cctaccctct cctgtgggac 54900 ggcccaggcc ccattagctg gtgtttttat ccttgtccac ctggggagct ggacagggcc 54960 ctgggtgatt aggcccagca cagcctcttg gcttcaacgt gggcacatgc atcctccttc 55020 tgggggtcac tttcttcctc tgttaagtgg ggtgagaccc ctaagctcct ctgaggccca 55080 aatgagtgtt gccaatggtc acggcctgtg tagcagggaa aagagaggcg agaggcttgg 55140 aagaggccat gcccgggggc caggtaagcc gagctgctgt aggtgacagc ccctcatagt 55200 cctcctctct gcccctccca cctttcctgt agctgtggtg accttggagc cctgtgaggg 55260 ggcagacacc tacgtcaatg gcaagaaagt cacagagccc agcatcctgc gttcaggtat 55320 ggctggggac tccgggggcc agtcaggtag gcagaggcat gaggcgaggc ctctgttccc 55380 atgtccaagc caccgcctcc tgtgcactgt gcgggatggc agctcttaag ggccgctggg 55440 caggtagggg agggggctgc gggtatccaa gcagctcatg tgcctcccca gtcccccaac 55500 tccaggaaca cagcactaca ggccccattc acacaacaca ggggccccga gacactgagt 55560 ccgtgctgtg ggctgagtga ggagccaggg tgtgcctgcc taggaagaag ctcctgcctc 55620 ctggcccagg actctgccct gtcgggctgg tctgggggat acagggcagt ggacaagggc 55680 ttcccagagc tgaggtgttg tggagctcag tggggtgggc tgctccagtc tctgaatgca 55740 gcaccccggg tggggttggg ctctgttccc agacactgca gtgtctgtga tgttcaaaca 55800 cgtgcaggca cacgtggcat aaagtccctt ctttagagaa gtcagacagt cagacagggg 55860 gccctcttga gtggtgtgtg actattgccc acgcagttag ggttctgcca gagaaacagc 55920 agcagcctga tgcacagaca tggctgtaga catgtaccga gatgtagtga gataacgtac 55980 aaccatgtct aggtataaag agatttattt caaggaattg gcttatcaga tggtggggct 56040 ggtcagcgaa gtttgaaatc catgggcagg tggcagtctg ggaactcagg gcaggctggg 56100 aactcggggc aggctgggaa ctcggggcag ggtgggaact tggcaggagt ggactccatc 56160 cgctgggttt cttcttcctc agaggaagcc ccagtttgct cttaggtctt cacctgcttg 56220 gatgaggccc accccaccgt tgggggcctc cttgatttcc atcagctgat tgcaggtgtg 56280 gagcacatgt gcagaaacct ccacacaaca cccagggagg gtgtggctga atcactgggt 56340 gctgtggcct ggccaggctg acataaaagt gaccattggc ttggaacagg ggagaccctt 56400 tcctaaccct gtcttagggg aaagcagagg gggtgaggag gggcaggtga cacccagtgg 56460 ccccacttct agcccatctg cccacccccg aaggctttcg gaggagtctt cgggactcag 56520 gagtcctgcc tgtggggtcc ctgggcagga gggcaggaca cactgaatgt cctgaattcg 56580 tggggtggcc ttgtaatggg gagtcggtgt ggctaagcct gggcgacagc tggtcagacg 56640 gacagagaga cagctgtgcc cattctccct gcttgttttg gggttggccc tggtgcctgt 56700 ggggctcagg gcagggccta ggctaagaga ggccttagct tggggtttcc ctcccagtgt 56760 ccgaggtggg ctgcatacgg cctgtggaca gggaggacag aggaagtggc cagctgagag 56820 cagccagcaa ggaggtgctg aggggggaca gacctgcagg cacgggccac ctgggtggga 56880 ggcagggcag agccggctct atggggcccc aagacagagc tgcagctact agggaaagtc 56940 agaggaaaac taggccatcc aaagagagcc cctgcaggca ggactgtccc aagacagtga 57000 gtgctgccct ggagggccct gcagatgggg cagccctgag gggggtccag ccgggtgctg 57060 gggtgggagg ggctggactg atgcccatgc ctcggtggcc ctgatgctga ggctctgcag 57120 ccacctgtgc ctgctagtgg ccgtccctgc ttccttcttg tggtctctgg actccggacc 57180 ctggacccca gccctgggca caggggacct gccccagccc tgcttccagt ctagtcgggg 57240 agacagatgg aaaggaaagg tcctgtgccc tgcagcagtg ctctgtggag ggcccaagtc 57300 cagctctggg ggcaccggcc ccagactgga tgtgagaagg agggtcctgg ctcccatgtg 57360 tgcacagggg cttgggggca ggaggcaagt acaaggctgg cctggggagg ggcggggaca 57420 ctggagcaca gcagaagccc cagatctgtg gtttgcaaat gtcactggat gctgagtgga 57480 gagtggccaa gggtggattt atggggagag tgaggagaca cattcaggtc ccagcgaggg 57540 ctgaagaagg agtggctggg agctggggat ggtggggtgc ctgcacccgt tcccctttct 57600 cctcacgcct ccccgcttga gaccatcagg gacctgaaga tccccatccc tcaaggccac 57660 ctgtccctct gttccccagg aaaccgcatc atcatgggta agagccatgt gttccggttc 57720 aaccaccccg agcaggcccg gcaggagcgt gagcgcacgc cttgtgcgga gacgccagct 57780 gagcctgtgg actgggcctt cgcccagcgt gagctgctgg agaagcaggg catcgacatg 57840 aagcaggaga tggagcagag gtgaggcgga ggccaccccc aactgcctgc tgcccctcct 57900 gccctcccgt gctcacccca atgccccctt gcaggctcca ggaactggag gaccagtacc 57960 gccgcgagcg ggaggaggcc acctacctgc tggagcagca gcggctggtg agtgacgtgg 58020 ccccgccctc cctgcccagc ccccacccac accaggggac ccctgtcctc ccacgccccc 58080 actcctccct gcttgcctgg ccccatctct tgcatctaaa cagtgggatg tggtgaggcc 58140 cactgtctag gcgcagtgtg agaggcccag gcaggtaggg ccgtagtgga gtcacaggcc 58200 ttgctttctg caggactatg agagcaagct ggaggctctg cagaagcaga tggactccag 58260 gtactacccg gaggtgaacg aggaggagga ggagcccgag gatgaaggtg aggggtcact 58320 gggccagcac ctgctgcgtc aggagggtct cagcatggag gtgggcagcc ctgggcctct 58380 ccctggaggt cactggtcag cacttttgcc ctggggtctg gacctgtctc tttagggaaa 58440 gacctccttg ccctgggaag caccgtggaa gcagcattgg gggagggggg atactgtgcc 58500 acagctggca agcagctctg cacactcacg cactggcgtg tgtacacaca tgcacacatt 58560 cacgtgcaca catgtacaca cgtgcacaca catgctgcct ctaacaggag tggctggatg 58620 atgatgggga atggggctgg taggggctca ccatgctcat gcgtccactc ttcccatcct 58680 gctgaccaca aggctcatgg ggcccccgag gaagagtcca ctgtgcacat cacctcagga 58740 ttccctcagt gagcatgtgc tccgggggcc aacccagctg acctcccgca gctgtgggca 58800 gaggtggccc acatgcaggt ggggaggggt ttgcacccat ctcagcctct ggccaggtgg 58860 tcagcagctt tgtgctggca tgaccttggt atcttcccct gtttggcctc atttacccag 58920 cgaagctccc tcccacagca aagctcaggc gtgccagatt gggggcagcc aaaggcgtgt 58980 agtgctgtgt tgggaggagg ggtggggtct cagcacaagg acaagtccct ccttgtgtcc 59040 ctgcttgtcc ttctctcaag ggcccagtgg acagacaggg catgggtcgg ggagagagtg 59100 tacgggccag ggccacctgg gagcacctgg cctgccctcc tgcctcctct cctgtgggcc 59160 ctgctcccca ctgctggccc cagatggtgt gtggctgtca ttgacggtgt tgctccccca 59220 gccactctga tcttcagcct gactcacaag gctgctcgtg gcggcctctc ctttggggca 59280 tgcagagctt ttcatgttgc tcactgtgac agagctctct gccggtttct tctttctgtg 59340 tacccaaata gttagtgtga aacggggtgg ggggcaagca cagagctctc ccagcccaga 59400 cccagagtga gaggaagcct ggggagagag gggcctgtcc acctctggcc tcagtgacca 59460 cagggggagt aaccttccag ccttccatct tgttacctga taaccacccg gccgtgatgt 59520 acacagagca cagggtcagc ttaggcagcc ccatggagtg gccgaccagc ctgaccttcc 59580 agagggcggg gcatggtggg cagggtcatg gccttcctgc gatgaccacg tgtgacctct 59640 ccccacagtc cagtggacag agcgggagtg tgagctggcg ctctgggcct tccggaagtg 59700 gaagtggtac cagttcacgt ctctgcggga cctgctgtgg ggcaacgcca tcttcctcaa 59760 ggaggccaat gccatcagcg tggagctgaa aaagaaggtg ggctgcccac tggctgtacc 59820 gtttcctgtt ggagagagtg tgtcacctca ctcatgacgg ggacagctac ttgggactca 59880 gcacttggct ctctgccggc cccgggggtg gcatagcagc cctgcctgac ctggcccccc 59940 agaagggtgg gcagtgaggg agcccagacc tggccaggtg ggacttggct gctcacggga 60000 gacggcggcc gggtgggcag gcaggaagta ggtggtcccc cctggcggct gtctgaaagg 60060 ttccagtgaa ccattgtggg gcaggcagct gaaatctcca gaaggtggga aggaagcctt 60120 tttggggacc tggcaccctg tcccccaagg agctgacgag tggtcatctt cccctgtcac 60180 aggtacaatt ccagtttgtc ctcctgacgg acacactcta ctcccctctg ccacccgacc 60240 tgctgccccc agaggccgcc aaagaccgag agacgcggcc cttcccccgc accattgtgg 60300 ccgtggaggt ccaggaccag aagaacgggg ccacccacta ctggacgctg gagaagctca 60360 ggtggggctg gagggccgct gggtggatgg tgggagggtc ctcctgggca gggctgaagc 60420 cacaggagcg gtggtaggca caggcttcac agcgagtacc tgcagacacc gctgttcctc 60480 ctgttccaat tattttaaaa tcagaagaaa aatgtgaata gagtccagcc ttgtagaatc 60540 ctcattctct ttctaccaat gcagcaatca tacataaaaa tagatttgga cattttcttt 60600 cggaggaaag gacagatgag gggaatgctc cctaggccca caggggtcag gacggtgcag 60660 tggaggggag ggcaggctgt ggcaccgaca gaacaggctg gcggagcgcc aagagcgggt 60720 acagcagggc ctgaagggtg gctccccaga gggactggga gaggtggtgg gggatggaag 60780 gaatgccccc ttgctcctcc attcaggaag ctgccgggag gtggatccct tagctgagcc 60840 cagtggaagg tggaggagga gctgaggtgg gggtggtgag gaggaagcct gggctgtgcc 60900 cctctgtgcc caacgtgagc tggtgtcctt cctaaagctc ggcctctgct gtccccacat 60960 gctcacgctg atttgtcttg agcccttaat tttttttttt ttttctttaa gagacagggc 61020 cttgctctgt tgctcaggct agagtgcagt ggtgtgatca tggctcgctg cagctcaaac 61080 tcctgggctc aagtgattgt tccacctcag cctcccaagt agctgggacc acaggaatgg 61140 agtgcactat gacacccagc taatttttga attttttttg tggtagagat gaggtctcgc 61200 tctgttgcac aggctgatct ctaactcctg gcctcagcca atccttgcac cctggcctcc 61260 caaagtacta gcgttatagg tgcaagccac tgcacccagc caggcctcaa gttacggggg 61320 tgactgagtc accatgtgag gtcagcgcca tcagtggggg agttgaatgt cactcacagg 61380 cccctgggaa gcagagcatg gcacgcccca ccctgcaggg ctacaggggg aggcaccagg 61440 cagagaggag taggagtagg ggaaggccca ggccacagcc tggggttgtg ggaaaggcca 61500 ggcagagcag ggagacagct taggcttggc tagtttgaat aattctgcag ggctctgggg 61560 catagggctg tccctagttg tctggtacct tgtcctgggt gatttaggcc agggggaata 61620 ttggcctggt gtgtgaaaaa gttagagaaa ggaggtggct ggggtacaga cttgggattg 61680 gttggtttgt gtaggaaagg caggggtgat ggcaagttgc tgactgtctc taggaattat 61740 caggacctgg gcagccctcc ccagcctgca gtgcccccca aggaagtcaa aacatcacaa 61800 gatacagaaa ataaaaatat gattaatgca ttcatacaca catacacatt catgcaaaca 61860 cacacacaca cacacacaca ctcataagca ttcatgaaga tgtgcacata tacacagcat 61920 acactcccac actcaccctc ctcactcttc tgccctgttc tcccaggtta cgtggcttgg 61980 aaggacggac agccactgtt gatgtggttt ctcttatacc tgagatctag gggcacaatg 62040 attgcttttc ctttgtccta cattaagttt ttcttgggaa taataatttg taggctattt 62100 tctctgtctt ctgtgtccct acccccagtt tgccctttat tcctcgagct cttgcgcctc 62160 tgtggcctga tccccgtttc tgagcttcac ttgggttctc ttcccacctc tccgccagct 62220 ttccagcagc ccagtgccgc cagcccctct agcccctcac tgcttgttcc ccagcccacc 62280 ccctggaggg agtttgggag gagctgttgg tgaccttgcg tgcttagctg agtacgttac 62340 ttgtgactga ccagctctaa gggtcacaga gggggtctgt ctagcaagcc ccctggacct 62400 tgatgaccct gagctggatg tggtggccag agctaggctg agcccactgt ccccaggaga 62460 taagggtgtg cggtgccagc tgctgagcgc tgggcctggg tccacattga cccctgccgt 62520 ccctgcaggc agcgtctgga cctgatgcgg gagatgtacg accgcgctgc agaggtgccc 62580 tccagtgtca tcgaggactg tgacaacgtg gtgaccggcg gagacccctt ctatgaccgc 62640 ttcccctggt tccggctggt gggcaggtgg gcgcctcctc ccttccttgg cagagagaga 62700 gattgagaga gagagatggc agtgggggta ggagtgggcc ctggcctgat acaaggagcg 62760 gccctgacaa gtgcttttcc agccccatat tcccagccct gtcctccctg gcctgaggtt 62820 cctcccagcc attcctctcc acacaccaca gggcctgtta tttcagggga cgtgggatgg 62880 ggtcttggca ctgccaccca aacccactgc agggctgtag ccgccagaac ccatgggtcc 62940 atgtgtatga atatgtgagg ctcccaagca aactttccag gtcacctgtt ggtcctgagg 63000 gtgggaacat ggaggcaggg ctgtgtcacc tgagccttac aaatggctgc ctccttcccc 63060 ggtctccagt ctggggtctg cacccagccc ccttcacccc atgggaccgt ggtattctga 63120 ggcctcaacg tggccaaact ctcgaggtcc tcatatggcc tcagccactc ccagccgaga 63180 cccctgttct cagtcccacc tgcaggtgtc ctccggaacc ttccggaacc ttcctgctgg 63240 ccatacatgt gatttctttc caagcctggg ggcacagttt tggttctctc atcttttaaa 63300 gcagcattct cgatggtctg tgtgtttggt tttggtttta aacagaagcc ccccagcccc 63360 ggccccggcc cctgttcgtc cctgcgagtc gctggtgtta acttctctct gtcttgtcgc 63420 actaacctca gttcagccat ctctggctgc aacagctacc ctcttctcaa cacatgcatg 63480 agcgagcgca tggctgctct caccccctcc cccaccttct cgagccccga ctccgacgcc 63540 accgagcctg ccgaggagca gagcgtgggg gaggaggagg aggaggagga ggaggaggag 63600 gatgaggagg aggaggacct ggaggacgac gtctttccgg agcacgcgct gtgcgacggc 63660 cgggacccgt tttacgaccg gccccccctg ttcagtttag taggaaggtt ggtgaggtcg 63720 aggagagcat gctggggagg acccagctct tttgcacagg agcactgctg cgggcacaga 63780 ggaaccgctg gggcctggcc cgggccctcc cagggcaggc gaggcaggtg gaggggctgg 63840 cctcctgagg agagcacccg agggcccccg ggccctgcat ccttgcagtg gggctgctca 63900 cccatcctgg agacggtcgc tttgggccgg cagggaagag tctgggttcc aggtacagaa 63960 gaggtagtgc accccggagc ttgcagctgt ggccccaggc aggtgggact atttctgcag 64020 agaggccgta ggaaccccgg agtggctcag gcacccaatg gccgagttcc tccctgaaag 64080 tcccagtgca gggcccaagg ggcatttgat aggtgagggc cagccgcccc caagcaggat 64140 gcccgtcctg tcattctcct gggaatcaac actgtcctag cggaggcagc ctcaccccag 64200 ctcagctgtc atccagaaga gacagaggct cccggctgct ctcagtgctc tccactctct 64260 ttggggaaag gagctgaact cagaggcagc catcctgagg ccacttttag gagtgggagg 64320 cagctgctaa ccctcccatc tccctctgaa atgatggggc ctgggcaaaa catgcctgtc 64380 taaaggtgag gactactcca tccctcctga cctcctcggt tgtcatggcc agagatggcg 64440 gcatgtggcc caatgccctc atggaatgtg ccctttgcag agagaagctg gttatcacgt 64500 tgcccaaatg gatgagaagc cacggttggg agacagaatg gaggctgggg aagcccagac 64560 ccagggagca gacgtcccac cctgctggca gatttggcaa atccagctgc ctttctgtta 64620 tcatggaagg gaagtcaggt gaaggaaaga tctagaaacc tggctgtagt agtcagaagg 64680 tcagctcacg aaacagctga atttatatat tttacatata tgaatgtcat aagataattc 64740 ttaatagcaa cctttttttg gcgattaaga ttgcttccct gggctaggcc agtggaagtt 64800 ttcaaaagtc tggagcttgg agcagcagtg ctgacagctg aaggctaagg gtggccccag 64860 atcgcagggt ttacacgggc tttactctgt ccttgggtgg agatggtgga aggaaagcct 64920 caccctccct cttggaagac agcaggtcct catgggcagg tgccatggat ttattctgat 64980 taatttttca tgagtgttac taggctgtga ggtgagataa gctggcctac cagataaaaa 65040 cctgtggcac tctccctccg agatgctctg ggcctgtact tcccactctg cagggcccaa 65100 gagggagcag tggaccccaa ggccagttcc atgcaggcct ctctcagaaa gccccgggcc 65160 gtagggccag gccccctgca cctcctgggc cccaggagtg gctccgggtg tcaggtaggt 65220 gagggatcag gacgcacagg gggatgagga catcaggaga agtggggtgg ggctctcgca 65280 gtctcagcca gaaagagctg ggtccttcca acattttttt ccccttttgt ggatttgaga 65340 ttttacgaaa ctaccaaacc aaacaaaagt catcaaagag agacctggcc cccatattgc 65400 ggggtggtct gtgaagggct tcattgggaa tcatcttgat ctttttggtt tggcaagaat 65460 tggcttctcc catgcagcag ctgtgcaggc ccggccctgg gaaggcccct cgttgatttt 65520 cctttaacct tctggtagct gctggctctc tctccaaagc ttcagcgaaa ttggggcacc 65580 cactcttgtc ccctctggaa aggcttccct gggtcccagc atgcgtcttt gcacctcacc 65640 aatctgtggt tagcacctgc ctcctccctc cctcccgcca cactcagccc tcgctctgtc 65700 tgcctctgct gctgcctctc ttgggctggg tttcagtctg cttcaaggta ccctggcctc 65760 tgcggaaggc ctatccagca ctggcctcct gtgttctgca ctggggctcc tcacccaagg 65820 ccagggtcag cccccagggg cctctgcctc tggcggtctg gggcaccagg tgacctgggg 65880 aggcaggtgg gttggtgacc actgcccata ttccaacagg agtgggcctg gggctctgat 65940 ttcccctggc ataggagggg taggaaacac aggaagggtg ggtgggcaca ggagctgcag 66000 agagagcagg gcgagaggct gactgcctgg gataagggtc cctgggaggg gagcagggct 66060 ggggagggag cgcaggtgtc tagggctggg tcgataaacg ttgctccagc tcgagggctt 66120 cactctgggt cagctctgtg ccctctggac tggcaaggcc acgccactcc cttgggtccc 66180 acatggtgct cttggtgggc tggggcccct ctgtcttggt atttgtagca tggctgcgga 66240 tggcgtctct cggcccgaga tcctgagagc cactctgcgt tgggtgtgtc tgtggctggt 66300 agggacaggc ctgggctacg ctctggttcc caactgatgt caggttattt ctggcaccta 66360 gagggcaggt gggggcatgg cctgcccagc atgtgagacc tgcggccctg gagggtgtct 66420 ccactgggca gagacgccag gctccaagat gccaggcacc agtgctctgc cccatcacct 66480 cacacttcgg gtgcattggt tggcatgggc tcttcgcaga gtggaggggc accttccggg 66540 cccagctcac agctctcttg aggctggtgc tgccactggg gcagtggatt cagggcccta 66600 gaggtccctt ctggctgaac aagtctatca ccgagccagg cagactggga cgggcagtgg 66660 ggagaggaga gcacccagca ctagagccac agccagatcc acatgtccca ccggtggcct 66720 ggggcccgag gtcagtgcca tgaggatgct cacagggtgc tgtagagatg ggggagcatt 66780 tggtgtcaga cctccggggt ccttttcatt gtataacctc tacctggatg tccctcgggg 66840 ccccaccccc agcagtcccc acctttgggg cacagtctgg gctgcatctt gcccatctgt 66900 ttgaaagcag ttagcagcag tctgtgatgc tacagtgtct gggtcctccc agcccccagc 66960 atgaggacag tccaaaaaag catgaaacaa tcgatctgct taatcaatca gctgtgataa 67020 ctaagcaggt gcccaggtga attgcccact cagagtgggt gaggaggtgc ccatggaagc 67080 caaccctggc cctagaagta ggtggtggag cttggtgtcc acacagttga gctggagatg 67140 agtcccttgc aggcccttgc tgccaggccc tggtgacttc cttaatctct ttgcctcagg 67200 gtcgtcctct gtgcgatgag gtataagtac catatttcat cgttctaatg tgctgagacc 67260 ctgggtggat tttttgcatc tctaagaaag aagggtgcag ctggttgagt tgagatggct 67320 gtttattagg acgtgccctg gcgaggagat gggggtgcac tgcctcccag gaggtagaag 67380 agcaaaaggc cctgtgtgct cgccactgtg cttggcccct agggagcctc cacagatgcc 67440 ggctgctgtg atttctgcca tgttgcttca taatgggatg atctgagcct ggggttgcga 67500 ggggcttggg cctcctcctc gagcccagcc cctgtctgat ttgtggggca ctcgagtctg 67560 tgctgtgctg ctggagcctg agcccacagt tggcaacatg gcagaaggcg tctcctcaga 67620 gtcagttcca cacagcgttt gttcagcagg gagcccttgt ggagagagcc aggatggggc 67680 ctgcctgcta cagcctcaca atgtgacctg ggatgggcct ggcccctgcc tcagtttacc 67740 tctctatgca ctgcctcaga cccccttgga cctggccttt cagggcagtg ggggagagtg 67800 aggaggggat cagtgtgaga ccctgagagc taagagtggg aagggagtgg ccccttctct 67860 agctcaggtg cagaagtctc ctccctctgg gtgtggtcct gggtagctca gaagttggtg 67920 ggtcaccttt gtggtgccat gagtggcaca tgtggatggc cccagagccc agggctctgc 67980 tcactgccag cagcccctgt ggaattgccc taagctttgg gaaggcagct gtggtgatgg 68040 gtctttgggg gtaggaaagg tagtgtctga ccctgtctgg gtggccctgg acagctctag 68100 cctctccttc ctgtgagctg cgccaatgga ttcaggaacc ccgtgcctga gtgtcctcac 68160 ctggcccaca gtgggagtgg tcccaggtcc tgccccctct ccgagcacca ccccatgggc 68220 ttcctgcaga gtggggtggg ggcagtctct tcatcctcag tgcccttctg ccctccaacc 68280 ctgggatttt tgcagtgggc actagctctg ggaaaatgtg gggtgggtgg gggctggagg 68340 gcaggggctg gctcagagcc ccacagcatg ggctgtcccg tctggtctca ttatgtctcc 68400 cccagtgtgg tgcgccagcc acggggaaga gccgtgctgt ctggcggccc aagttctggc 68460 tctccccacc cccactcctg gacaacttag ctttgctcag tttgtagcag ccccttttcc 68520 cacccccact gtcaagcaga gacccttgtc caggagcccg gggtgccctg gggagggaag 68580 gcattgccgt ccccctccca aggggatgct ggtgagtccc tgcctgcgga gcacccagca 68640 ggactgtggg gaggggcccc gccctgtggg cctcagtgtc ctctcgtgac tagggccagg 68700 gtgagcttcc atgggcgctt ctggacataa cctgggtggg tggcccaggg cagtggagct 68760 ccagccccca cacctaagtc aggcagagcc gcctgcagcc ctgtgggtaa caagtccctg 68820 atgggctcca ttggtgtggg gtactcgctt ctcggggggc atcttcagag ggggcgttgt 68880 gctggggaga gggcccaaaa agccaccagg ggcttccttt acccccggag agaggcctga 68940 ggagactttc aggcccctgg agggcagcaa gacccttttc ctgttgcgag cctgggccat 69000 tttgcagtga gggcgttggt gaggtctcag cttagcaggg ccactcagaa agcgagggag 69060 gtgccatgag gatgtgtaaa gtcagaatga acgagacggc caaggggaag gtcctgacag 69120 tgactgggat tctggggcct ctgaggaggc ttgaggccgc agatgagatg gagggtaggg 69180 cttctgcatt ggaaacagag acacccgggg catccatgga cccatgggcc acaaggctga 69240 gcttgactgt gctggggagg cagggcctgg acccccaggg ccacatgggg catggacacc 69300 cctgcaagga gcttgagtgt caccaagggc atggggggat gtgtctgact ggtgccttaa 69360 gacctttctg tctgctgtgg gggccatggc agggtggctg gtggtgatgg gacagttgag 69420 gggggcttct tgaagacttt tgaggtggaa ctgatggatt tgatgagtag gaggggcccc 69480 tgtgctgctg gtttctgact tgctgctgca ggaaggtcag gggtattagg gtgtggaggg 69540 agcaaggtca ggagcccacc tgagagaggt gttgggcgtt cacagcccgc tgagtctcac 69600 tcatcccctc atcagtatct gctctggaat cgagggcccc aggcacggcc ctttcccatg 69660 ctggaggtca tggtgctcag agccacacct gcctggagca ggaagcaggg tatccttccg 69720 cctggctgtg tggcgtgggg tcttccaggg tcctctctgt cctcccagct gcccacatat 69780 tggtcagcac agggaacgca gcagctatct ggcgaccgta ggtactcgtg gtctctgcct 69840 aggccggtcc taggaaaggg ggatcttggt gctctgggtc tctgacaggg caggctgggc 69900 cgcaccgtgg ccctgggggt gtcctcaggg ctccattcag cacctccctg ggccctgggc 69960 tgggggtgcc tcatcttggc caactcacct cggagctccc acctgccgag tttctgtctg 70020 gggaaggggt tctgcggggt ccgtgagcat cagggacccc tgggaagtgg gcaggaggca 70080 gagcgatgct ggccatcagt gccagtgtga aaaggggggc agtgcagtgt ggtctgggtc 70140 ctggtctggc ccccgtcctc cttgaagcag gctgaaacct ccctcctcgg ctgctccctt 70200 ctcaggcagc caggtccggg cccagctgga ctgtgcctct gctctccgca gctcattcct 70260 cgtcctcctc tctgtccctc cacctcctgt ctcctgtgag tgcctgccct gcctgtcccc 70320 gcccgctctt gctgtcctgg ccttggctgt cctgtccggc ggcttccctc tgctttgcag 70380 ctccatgttg tgtcgtgagc caggccatgc tgccaccgct gccgttcaga acatgcgtgg 70440 aggggtggcc catgaccgcc gcctctgctt ctccccaggg ccttcgtgta cctgagcaac 70500 ctgctgtacc ccgttcccct ggtacaccgt gtggcaatcg tcagcgagaa gggcgaggtg 70560 aagggcttcc tccgcgtggc cgtccaggcc atctcaggtg cgtgtgggcc aaaggccgtg 70620 tgtggcattg gagcccctgg ggctggctct gacctttgca ggcagaggcg tgggcccaag 70680 aagggccttc tggcatcatg tagtggttag tgggaagctg gcctcagctg gccctccact 70740 ctccctgggg tcaacctgaa gctgtttttc cacgctgtcc tgggctggcg ccccgggctg 70800 ctgccccgca gtgggccctg gaggggaagc ccctgctgcc cagctcttgg ctctggactc 70860 cccagggtca gctggaggtg ccttgggggc tgtgcaggct gagcccagtg ccatctgagc 70920 ctgctctggt tgggggtttc caccttccca tcaggcagtc ccatatggac ccaagaccac 70980 ctggatccct cccccagcct gctgcagagc aagtgctctc tgtcaacaca ttccacccac 71040 ccggctgtct ctgcagcccc aggaaaggcg tgtgaggccc agtccctggc ccctgggccc 71100 tgctcagggc agccctccct ggggtgcttc tggttccctg atgcattccc tggtctctca 71160 ggcacaggcc tgtccccctc cacactgggc ctgaagacac aagcccctcc cttgtgggag 71220 gtggagactg gtgctgctca gcctgctccg gatggccaga ggcaccaggg cagccccaga 71280 gtgtctgagc cttggtttgc tcacatgtaa acgggatccg ttgtaatgct ccccacctga 71340 taggaatgtt gaagggtact tgagaacaca gatgtgagag cgcttggctg cctggaagct 71400 gcagggcaac aggcggcttg tgccgtgagg gaaggtccca ctcccttccc tgcctgcccc 71460 gggctcctcc accaaggtct cccctcacca aggagcactc tttttcctct caaaggcctt 71520 ggctgcctgg gcaccctagg gagggagtag tacagacaga cagacacaca gacaggcaga 71580 tggatgcaga gaggacgtgc atccatggct gcaggggggc tcctggctgc cgggctgggg 71640 ctgcttagag gagcgacctg gagcaggctg agatggccat acccctcccc agatggcaag 71700 tcccccaact ccgagatggc tcatattctc caccctgagt tacctcatat cccctgcaag 71760 atgcaagatg tctggttctc ccggctctgc tatcctggct gccttgggtg attttaatcc 71820 cacctaatta atgaagttaa tttgactcta atgttaaatt ctccttagcc cataatttct 71880 ttcttttctt tttttttttt tggacaaagt cttgctctgt cgccaggctg gagtgcagtg 71940 gctggatctc ggctcactgt gcaacctctg cctcccagtt caagcgattc tcctgcctca 72000 gcctgccgag tagagtagct gggactacag gggtgcgtca tcacgcccag ctaatttttt 72060 tatttttagt agagacgggg tttcaccatg ttggccaggc tgctctcgaa ctcctgacct 72120 caagtaatct gcccatctcg gcctcccaaa gtgctggaat ttcaggcgtg agccaccacg 72180 cctggccagc caccctgccc agcctagccc ataatttcta aatgctgttt atagcacctc 72240 ccactggcca tgtcattgct tgtcatccag tcactgtgat accacagtgc tgagaatcag 72300 ggggcccagc tggggagtga gggtgaacac cagggaaggg ccccagccct gctgctggaa 72360 ggtggggtgt ttaccagggc tgcaatactc agggaagctg ggaacaccta tcacctctgt 72420 ctcccctcca ggaggtgcca cccccacctc accaggtcct cccaatcctg ccttgtgcca 72480 gcagctccca ccaagtggtc aggatggctg agcggagcca tcctgagcac ttcctcccac 72540 tggcccccac cctgacagcc acttcctgag agtggggctg caccagaggc cgtggggccg 72600 gcccatgtcc ttgtgagggc agctgccgtc ctggtctgcc cttggtcaga ggagctctct 72660 ggggtccaca tggaggtttc ccatttccca ggatccgagt tcaagctcag tgcaaagctc 72720 tacctttgtc ctgcacccta tggggttgag aggtaccccc acctctcaga tgagtgtcgc 72780 cagttaggaa ggtgtacagc agctctgagc ccaggtctgt gtgcccaggt ccacagcccc 72840 tgctatccca tgtcatatac tgggaaacca gactgggata gtgcctagga agtgctccta 72900 tcctgggctg cgtcgccagg cctcctgccg gccatcctac aactggatca ttttatgttg 72960 ggtgatacct aattgtttcc ctgtctaatg gctgtggtgg tggagaaggg aacttagaaa 73020 aggcaccggc ccttgcactg gtggtgtcag aagtctcatc agccctgccc gtgacccggg 73080 cgaggtcagt ttgctgttcc ctcagcactg actcctgcat gagcaggcgc tgactgtcac 73140 agaccatggc aggacagagc tcagggcttt aggcagcagg tccactgaga gctttgaagg 73200 ctggggagtg tgggcgcatg caccggcagg cctggggagt tgcgtggagg ggcggttggt 73260 ggcccttgaa tgtctaggca ggtgacaggt ggtagcttca cccagatggt ggcagaggca 73320 ctttgtgatt ctggaggtgg gaccagcagg gctggtgggg tggtctctgc acatggggat 73380 ggggaggggc tacctgggtt ctgcctgagc acctgggaat gcgggcaaga tttggttttg 73440 aaaatataga ctttgtgact cctatcaagg tgggctgtga tgaggccgtg gctgctttgg 73500 ggcccctggg caggcgggtg gtcagtgtgc cgggacatgc cctggttgtc actgagccac 73560 gggtggcaga ttcggtcagg ggtctgctgc ctgctctggc tcctgtgccc tcactttgac 73620 tgcggggtgg cccagcctgg ctctgcccac acccacctca ggggacaagc tgggctccaa 73680 ccatttgctc tgtttctcct gcagccgatg aagaggcccc tgattatggc tctggcgtcc 73740 gccagtcggg aactgctaaa atctcctttg atgaccagca ttttgaaaag gtaccaagct 73800 ccctcccgag tcccagacct ggaggtgcct ggcgctcact ggagtcctgt gcactttgct 73860 cctctaacac ccctgtgtcc catcccacgg gccctgagtc ctcttggggt tcttccctct 73920 ggtccagagc actgagcctg ccccatctct aagcacactg cgcccctttt cccgggtttg 73980 ccctgacccc tggatccgcc catctcccac cacggccgct ccagggtcca agtcggggcg 74040 cagagcaggt ggacaacacg agcctccaga acagacactg aggtgcagcc acccccaccc 74100 tgtctccctt ctctggacca gctctcctct gggtccccac agtacggcgc gttcccactg 74160 cccccttcgc ctgctccttc gcctgctcct gggctgcccc cctgaggctg cctacctgcg 74220 gtcctcatgt gaagggccgg cgctgtgtcc agtggcacct ggaccactca gtctcctctt 74280 ctgctcttga gagagtggtg gaggaaggtc cccaaagtgc accccatgcc acactcaggt 74340 ggctcctgtc cccaccttct tagactcgct tctcacccct gcccacctgg ccgtgccgtc 74400 acctggaacc tgggtgccct actccctgag cgagggtggt ctgtctgccc aatgcctttt 74460 ctcttggagg ggctgtcagt attggggatg cccaagaagg ggaggggaga gagctaacct 74520 gctggacaag gggccctggc aggcgggggt ccggctgaac tgaagaccag agcagagagg 74580 caggtggtga gttgtttcca ggacagctca gaactcccat ggccataggc tgtagaatcc 74640 aaagacacac atccacagca gggaaaactg agacctgggg aggtggatgc ccccctacaa 74700 ggcaggcaca ggtctggtgc gtgggttcat ggaggcccca gcccaggctc tgggtggcac 74760 agccctcccg tgggcctgtg gcagggtcta cggtgcccct cctcggctgg ctcctggctc 74820 tctctgactc tggtccccct ctgatcagtt ccagtccgag tcttgccccg tggtggggat 74880 gtcccgctcg ggaacctccc aggaagagct tcgcatcgtg gagggccagg gccagggtgc 74940 agacgtgggg ccctcagccg atgaagtcaa caacaacacc tgttcaggtg ggtcgcccac 75000 cccagctgcc cagggcgtag gggatgctga gacctggttc ctgagcccgg cccaggcctg 75060 tggctggaag acaatatggc ctggaggtcc atgactctct ccttgactcc cagcagcagt 75120 gcccccagaa ggcctcctcc tagacagctc tgagaaagcc gccctggatg ggcccctgga 75180 tgctgccctg gaccacctcc gcctgggcaa caccttcacc ttccgtgtga cagtcctgca 75240 ggcgtccagc atctctgccg aatatgccga catcttctgc cagttcaagt gaggccctgc 75300 tgcctttgtg tccctgcgct gcgcagggac tctgtgccca aggctcccgt gcctgggtgc 75360 tgggcaggga gcaggccatg ttggtgctgt gttggcccag cccgcaggcc ctgaacgccc 75420 cagcgccctc gtgtgaggtg ggttccacct ggtaaggtct catcccaagt cccccacccc 75480 acaccaaagc atctcctctg ctttgcagct tcatccaccg ccacgacgag gccttctcca 75540 cagagcccct gaagaacaca ggcagaggcc ccccacttgg cttctaccac gtccagaacg 75600 tacgttcctg ggcacttctc cccatccctg ccactgactg accctcccag ggcctctctg 75660 agcatggctc attctccctc ttctgaacac cagttgtggg ccaggactgc cttgtgcacc 75720 gggaactcca gtgccaggca gggtgtagga gcgatttctg ggcagtggga gacccttgat 75780 ggatttacag ctggggcatg ggggccgctc agagcccctg ggagctgctc atagtgagca 75840 tagagccgat ggggagccgg atgcaggtgc agtggggcct gggatttgta ctgagggccg 75900 ggggtgctca gccagggcag ccctggcttg ggtgttggga atgggaagga ggcagggcca 75960 caggggctac agggtgccgg caacgtcccg agaggtctgg aaaactccag gcaggagagt 76020 gatggcagct gggctgctag gatgatggag aggaggggcc tttaaggcgg agcagctcct 76080 tctccaggcg ggagaactgg gctcctgggg cagcagggga aagagtgcct aacggtgata 76140 aggaaagcta ccagggagcc aggccttgag tgccaggcca cgggtgtgga tttggcaggg 76200 gtgataacct ggagactcag tgggttagtt ggctgggact tctgtcacaa agcaccacag 76260 gtgggggcat ctaaaaacaa cagaaatgtg gcctcccatc gctctggagg ctggaagccc 76320 gggatgaggg tgtgggcagg attgccccct tcttaggcct ctatccttgg cttatagaac 76380 agccgcctct tccttgtgtc tgttcacatg gccctccccc tctgcgtgtg cctgggccca 76440 aacttccgct tttcataggg acagcagcca tgttggattg ggacctactc tgatgacctc 76500 tcgttaactc cgttttctct gtaaaggccc tatcccagga tatactctca ttctgaagtc 76560 ctggggttgg gacttcaaca tacgaatttg gtgaggggac atggtccaac ccataactct 76620 tgctgagtgg ggcaggacct aagaagggga gtcctgaaga gaccagcgct gccctttgtc 76680 acctttccca gctccgtgtt ctgaaagggc agctgagcca cgcggcccct gttcgtcctg 76740 gagagagagc ccgagggaca cactccagag tctgtctggg gcacgtggtg ggaggagggg 76800 ctgggctgaa gggcctagag gaggctgctg cccctgggca gacgtgggcc cagctagggg 76860 tcccagatct gggcctgaag cgcttagctc actgatgtga ctctccttcc cccttgaatg 76920 tgacctggcc gtgccctcct gtcctcccac ctgcctgccc accagatcgc agtggaggtg 76980 accaagtcct tcattgagta catcaagagc cagcccattg ttttcgaggt ctttggccac 77040 taccagcagc acccgttccc gcccctctgc aaggacgtgc tcaggttagc gccctgggtc 77100 ggggggttcg gggctgctgt cctcaaagcc cctgcccaga tcttttcatc cagctgtctt 77160 gaggctgcag agcctatgca ccccctgaaa cccacctccc ctgcccatcc aggaggcctt 77220 ttgcccaggg ctggcaggac tcagagagca attaagagct ctgggcctgc ctgcagcttc 77280 tctccttcgg gactgcagag agttccttgt gagcattgct tgacctcctg ctggcctggg 77340 cagtgtgcag gggctgccag ctgtaggatg ctggggtggc cccggggaga ccacttctgc 77400 tgcccaccga ggaccccagg aaaggggccc agctgtgcca caccctgggg aagcccggcc 77460 tagctccctc agtccacgca gcctcctgag gcctggaaaa tgggggctca gagagacttg 77520 cggggctggg gcatgaagtc aggacttcca ctcaggccat ctcacccaga cccttgaagg 77580 tggacaggag tgtctaccct gggccaagcc gacccctcct gggcacctcg agtgcagaga 77640 gaactgcaga gaggcctcgg gtgggccctt tcttcccatc tccatctccc ctcagctgtc 77700 aggcaggact gggagctcag gggccctcca gggtgtcagg gaaagagaag ggcaatgaag 77760 gctttgttct gggggtgctt gtctgtcctc gcgagtgcct gagggactct ggactgggag 77820 ccagagcttg acccttgccc tggttccctg tggcctctgg ggtgggagct ggggtcccaa 77880 gggtccctcc tcttcctccc acccaagctg gtggacggtc ttggagaaga gagggtggga 77940 ggggccggga tgggcacctg gggcctgtag cccttctgtc tccttctgac ccctcccgcc 78000 cagggtcccg caaacacctc acactggtcc tttctccaca gccccctgag gccctcgcgc 78060 cgccacttcc ctcgggtcat gccactgtcc aagccaggta ggaagggtct ctggagccgt 78120 ctcagggcag tgagctcccc tcactgtggg tgctgtagtg ggctgggccc ccgcagtgaa 78180 tgctgtcctc tgtgactggg ctgtgccctc ccaggcactc tggcgccacc ctgagcctgt 78240 caggcctcac ggggtcccca tggagcaagg gtctgccctg tgcccagaga gtagcctgga 78300 gctggtggca gaggtgtggg gagccaagga aggaaggcag caagagggtc gggggctttg 78360 aggggacttc aggcatctca gctgaacgca gagaggtgga gatttgggga tgaaaggcaa 78420 tctaggacgc tccttcacgg gggtctgagg ctggaggtgg gagcgagagt gtggggtcag 78480 tcggggagaa gtatttgtca gagcttttgc ctggagcctg gagcctctgc ctgtgggaac 78540 aggtgggtca tggaatagca cttgagatcc actggctttt agttaaaaga gtggagttta 78600 tttcctgcaa gaccaaaacc cagggacatg gtcgggggag agctgaagac agccagactg 78660 aggcccagca ggtgtggccg agtctctcat agcccagaaa ccctcctgaa ggagggagtg 78720 tggtcccggg caccagcacc ccagagggta ggggcctgtg tgagaagctg cttctgcagc 78780 tggtgggtgg aggcactggg tctgcacaca tggtgaccag gtgtcagcct cttgtgcctg 78840 ccttgcaagg accctgtcct cggaacccct gtaagatgaa ggtttgcggg ctgaggacac 78900 tgtgggagga caccctccag ctgctgcaga gccagtccct ggtctgtaca ggctttgtgg 78960 cccgcagtat gagttccctg agattcagtc ctccccacag cctgcaagaa agacctgtag 79020 atccatattt gtaggagagg cagaggaggg gacttgctag aagaggacct gtgtgatggg 79080 tctcagagaa gggagtggta gacagaggtg ggtgaaggat gtgaggacag aggctgtttg 79140 tcaggagctg gacacgagtg gagggtcagt gggagctgag ggacaggtcc tctcgggcca 79200 ggcctgggtg ctggtgaaat gtgcttggac aggtgtagta ggctgtggcc aaggtgtggt 79260 gtaggcaatg ggcctggcag catggcagag cggccccgtg agggttgtgg ggcttttgaa 79320 caagggtatg tgcggctgcc ctgttggttc ttggggtctt gaccactgtc ctcctcatga 79380 gctgtgccga gtgtacatgg ccatgtgcct ttcctagccg gggcacagag aacgtgagcg 79440 tccatgtgac gtgctaaggc cacagagtgc ccaggacccg gtgtatcttg ggaatggctg 79500 gggttggctg gttgtttccc ttgaggaggg ggaggtgccc ttgctgcctc tgagtccctt 79560 tggccccggc atctcctcct tgagtgtgcc cttggcacgt gataggtcag gtctcccatc 79620 catgcatgcc tccctcctgt ccctacagtg cccgccacca agctcagcac actgacgcgg 79680 ccctgtccgg gaccctgcca ctgcaagtac gacctgctgg tctacttcga gatctgtgag 79740 ctggaggcca acggcgagtg agtgctggtg ctggggcccc cagggcgtga gtgtgtgtcg 79800 gggggtgcgc ggagagggac gaggacttga gctgcctgag ggttgccagc atccagagtc 79860 gttcttccag cgggtgttca ctgcagacct cttgtgggcc cggcctcatc taggtcttgg 79920 ggagtaaaag cagacaaagt cctggaggag ctggcatgag gggcagggag gtgctggaca 79980 gataagcacc tgaattagtg tccccatggt cctgagcact aggacagcaa accagggtat 80040 ggctcagggg cagggcaggg aggcagacag cacttacaaa gtgatcaagg gacttttgag 80100 ggaggtggga ggggagccct gaggccctgg ggaggcaggt tccagggccc cagggtggag 80160 gccagtgggg gtctgcctgg tgccctgggg gcagctggga gctgggctgt ggctggcagc 80220 tcagagtggg gcctggtgga gactcggatc cttgcccaga gtgggacagg agccttagat 80280 gttggagaag acgagcccat ctgctgggat ttcctctgga tcctctggcc ttgggttgcg 80340 gatctgcagg gcatgagggg aagcagagga cccttgggaa cttacaaaga tccagcccag 80400 aggggccagg ctgtgccata ccgtgtctcc ttgttggaca ccctgccagt ccagtgggca 80460 gggctgggag gtgatagcca aggaggcctg gtgggtttct gtgctcagct gaccgtggtc 80520 tccatggatc agaccacctg atcttcacca gagggagctg ctgacttttc cctgtttttg 80580 ctcccgtcca ctgtgtcctg tgctgcgggg agggcagaga ggaggggctg gccgctcctc 80640 acatgtgtct ctctcttcca gttacatccc ggccgtggtg gaccaccgtg ggggcatgcc 80700 atgcatgggg accttcctcc tccaccaggt gtgagcccct cttgccccta ccctgcctgt 80760 gtcccctccc ccaccccacc aggtgtgagc ctctccctgc ccctaccctg cctgtgtccc 80820 cctccctcac cctacgtagc cccctgagcc gtctgaccat atcctctcac ctggcaccgg 80880 cagggcatcc agcgacggat tacggtgaca ctactgcatg agacaggcag ccatatccgc 80940 tggaaggaag tgcgcgagct ggtcgtgggt gagtgcggtg tgggggctgc cttggtgggt 81000 ggggctgagc tggtgggaag agtacaggcc ctgagctgga tacccgggtt ctaaccacac 81060 ctctgcgtct gttgctgcgt gaccctggcc gggtcacata atctctctgt gactcacttc 81120 ctcacctgaa aaggagagcc ttggacctgg gtgacgatct gcaaatttct gtttaatcag 81180 tgtattggag ttctggggct gccatgacaa aataccacaa accaggtagc ttaaaacagc 81240 agacatttat catctcacac ttctggaggc cagaggtcca aaatcaaggt gccggcaaga 81300 ggcgcgctct ctctctctga aacctgttgg ggaaaatccc tccctgcctc ttccagctcc 81360 tggtggtggc cagcatcttg ggcgaccctg gcctgcagac gcatcactgc attttcgcag 81420 gcttctcctg tcctgtgtct tcctgtggcc ctttctccta aggacaccag gcaggttgga 81480 ttagaggccc atcctgctcc agggttgact gcatctttac tcagtttgat cacctctgca 81540 aagccctact tccaaataag gtcccctttg aaggtcctgg aggttaggac ttccacgtat 81600 atttttcggg gacacaattc ctcccataac catcaccaag gatcttacac tcttttcttc 81660 catgacctca tgtttcgaat tcgggtccgc caaatgtttc ctttgctaaa gcggaaagaa 81720 tttgtcttct cagttttcat tcaaggaggc agacagtcat ccattcaagt gtgtcactag 81780 catgaggcca gcccagccct gccttgcccc agacattgcc atggccgggc tgggtggctg 81840 ctcaaggtca cttccctgag gctggacccg tcaccttgtg tcccagtgca ggactgtaga 81900 caggaggttc caggtacacc aggatacatg cttatgtttt acaagttttg tgtctaattt 81960 cacatgaatc agaaagtcat ggaacaagca cccaaaccct cctttcagag gttgtttagg 82020 gcaagcctaa gaagagtgaa ttgatttata ggcagaacgt aagcaaatac acagctggtt 82080 tatggacccg gccacacggt agttgaggaa cgatccctgg ggcagcactg ccctcacatt 82140 ctgagccctg gtctcacttc cctcaaggca gacaggagag aaggaagagg ggaagctgga 82200 tctgcatggt tgaaaggacg catccttcgg gcctgggtct gtcaccactc aggccccgcc 82260 tgctcagatc caccttctcc ccaccttctt tctaaaaagg ccaacaggag tgtctgttta 82320 tgtggggttg ggtgatcagg gatgctattt aaagggatct ggggagatat ggtatgaacc 82380 ccaatgctcc ccttcaggct aaggggtttg ggctcagcct ctctgggctt cgtgactgag 82440 cagccctgtg attggactca gggcacagag cagccaagtc actttctggg gagcacctag 82500 cctctctcct gctcctcacc tgggacccaa tctcactgtt cacagccttc tccaagctca 82560 gcatccctcc caagagggcc atgggacttt ccagccctgt gagttggaca ggactgggca 82620 cagggtcagc gaaagggatg aaagtcgagg agagaccccg ggtgtccatg agcagtgggt 82680 gggtgcaccc tttgaggcag gggagggagt caaagtgcag acaacagagg gtcaggaccc 82740 cagcccaacc cctggcactc tgtccagacc agcgggctca tgggtgtcag ttttgtgggc 82800 caggtacttg gtcagacgca gagcaggcta aacactgctt aagtgcaggc cccgagggct 82860 gagagcagct gcgctcccct ccccgagggc tgagagtggc tctgcccagg cagcgatctc 82920 tgcagctgag cctcttccct gccatgggca ctgcccagca tggacccaga gggccctggc 82980 gtggggaagg gcactttgct gggatccacc tgcctcttcc caggacctaa gtgctgcaaa 83040 gtcatgggtc agagttccag caatgggatg gggcaggccc agtgtgcacc catcaacaca 83100 aaatcctagc gtgtcctggg ttttatcttg tccatgcatg gcggagaggg aaggctgccg 83160 ttccttcctg gcgcaacaaa gaaaatgtac atgtgtttgt ttactccttt gaatgagcag 83220 aactgtcact gtctggccaa gaaattacta ggtgaagcca ctagacagtt ttcctgcctg 83280 ataacggctc tggtttcttt cacagagaca gacagacacc cccagtgcat gcaacttagc 83340 gggctctcct ggaaatgccc cttgtaagaa gaggttttat ggcacagaaa gtgttctctc 83400 ctatcccttc ccatccctcc cctcctctgc tcttctttcc ctccctccct tcctccctcc 83460 ctccctccct ccctttcctt gttattatca tgactttttg gtgtaagaag aagcaggaac 83520 attcctcctc tgtgtcttgc ttagccttcc ttttccagca gtcaggaagg ccggtggttt 83580 ccaggctaag cacctgcatt tgtcagtgtg tgtatacggg ggtgttcact gtggccgaga 83640 gacagacaag aaagaccgtg gagcagcaac tacacatggc acctgggttg ctgaggaccc 83700 tgtagggcct ccctgttccc cctggcaccg cctttgacag acgctctagt gaccatgtgg 83760 ggagctggct tgctgacagg acccccacct gaggcagccc cccagggtcc cacctgcccc 83820 ctgggaagtg acctgtggcc cgttgccttt tctgcaggcc gcatccgaaa cactccagag 83880 accgacgagt ccctgatcga ccccaacatc ttgtctctca acatcctctc ttccggatac 83940 atccacccag cccaagatga ccggtgagtc ggagactccc tggagacagg gcccagggca 84000 tgttcccagc ctgccaggcc ctcagccaac ccggcacagg gttcagccac acaaggtgac 84060 ccgctcaacg ctctcccggc cctccctcct ggcacctgca ggagctgtgc ggtgaggggc 84120 tggtggcctc tgcacccccg gctcctcgtt tgtgcacctc gttgctggtt caggcatccc 84180 catgcccatt tgtttatcac caagcagagg ggccagcgca ggggttggaa gatgagctga 84240 gttctgtcct cgggagtttt gtggttgcgt ggtgtgggga caagtggctg tatgtccaag 84300 gaccatgctg ctgtggatga gtcagtggcc tctggcaggc atcctggggc tagaggtgga 84360 gcagctgggg tgggcgccca taggcactgc ttggcacagg cccctcatca ccaggctgct 84420 ccttcctaca ctccttgcac ggccaagacc ccacagtctg ggcggtccca gcccgaccgc 84480 atttaggctg gggttttggc gctctgggat gtctgtggca gccctatcgg ggtctgctgg 84540 ggttagggga tgggagaggg aggcagcccc tgcggttggc ctgggcaggt ggctcagcac 84600 tgccaggggc agccctggtg ggtggggacg tcccgcgggc tccactgcgt cccagacgct 84660 gccttccagg ggcttgggga aagtgaggcg ggggctccag tgtccagtcc tggctgctcc 84720 ctgggggctc gacctggctc atgatgcaca agcccagagt ggaccctcag agctgaagcc 84780 gcaggtgtct ccatggctgt gtttgtagga aaacgtcttt gagggcctcc ctgcaaggag 84840 ggtcagggtc ataaggaagg agggtcctgg cgggcgtcgt ctcctattct tctgacttgg 84900 gtccacacaa agctttggtt tcatcagcaa cacccagaaa gtgggctatc ggggcttagc 84960 actgcagtaa ggagggcact gcaggggcag ccagggcagg gggcagctgg atagtcaggg 85020 tgggcacagc gctgaacagt ggggggtggg ggttgggcac agacctgggc agggtggatg 85080 cagctctggt cccagccctg cctgtggcct tccagaggga acttgccctg cactcatgtc 85140 cataggaggg tggagaatcc ggggggtgtt ctatgtggag gtggtgccat gaggggggag 85200 cacgtctggg agagggagag gtgaggcaga ccaggtggga cgggccgggg cttggggctt 85260 ccccgtgcct tgcttctcct gccgccatga gaatgctccc tggtgaggtg tggagaaggc 85320 ctggagcccc cagcacgggc gctgcctgca gagtgtgggc tgctgtgcct gggccatggg 85380 ggaccaggaa ttggagtagg gggtggggcc cggaagggcg ggtctgccat gtgagatgtg 85440 ctttggagcc tgggagatga cctcattacc ttattttcct gacctctgac ccccctcagc 85500 ccaggcagct cctggggtgg ggtgggcagg ggctccagcc ccccaacccc acctgctatc 85560 tctctgcaca gagggctgag tttctgaggt cttcctcaga agaccagctg ccatgggtga 85620 cgtaggaggg agcggctcat ggctggacct caggccaccc tgttcctgga tgcctgagaa 85680 cctgtcactg aaggggcttt ggccccacac cctgagggct gagacatgag gccggtccca 85740 gggtgcctct ggggttgagg cagccctgtt ctggggtcaa ggccctgggt ctgagaaagg 85800 aggaaggcgc gttgcgtggg cgcggcctcc ccgaagcggc tttggccctc gcttggctcc 85860 tgcccgtgct ggcagctccc acccctagcc ctgccctgga gcagtcttgg ggactgtcct 85920 ctgctggcac ccccaggcag gcaccgtcct gtggcttggc tgaccaggcc agtgggcctt 85980 cctgtgccat ggacggtgct ggcgtcctca gccccatgat gggccgggct gctccaaggc 86040 cgctctccct gacgtgcgga ggctcaggat ccccggcttc tggctccagc ctggggcctt 86100 ggccttccat gcgcttttcc atggccttgc ctcctgcccg ctcccaggcc ccacgctttg 86160 cagcctccct ggctcagagt gggcctgtgg ccacaggccg cttccctctg cctgtccccc 86220 accccgctcc cgctgcgctg cccggccctc actaaccgtg tgattgtttg tgttttgcag 86280 gcagtttctt gattcggaca tacctaggta tcatctgtga cccttggttt acccttggtt 86340 tcatttcagc ctcttctttc ctccctgctc ctcccctgac cgccccccat gcccctgaga 86400 agttaacttc cagcttcctg gactcctcac acacgtgctc acctgtcctc ctgttcctcc 86460 cgtcttcttt ctttttattc tcttggaatc ttggtttgat ttctttattg ctttcccacc 86520 ctgtcctctt ggctgagtcc cttcttcccc cactcctgat tttggctgct ttgtagtttc 86580 ctgctcccta gtagacactg gctggcctcc tgctcctcct gccccagcct tgcctgcccc 86640 gcgccacacc ctgccctgtg gatgggctcg gtgtcccgca cgctgctggc tggcccgctg 86700 cccttggctg caccaccctg tgaggaccag ccccgctccc ctctccctgc aaggggctgt 86760 agcaggcaga gccatgagca caggggttgg ggaagggcag acaggatcca gcccaggaga 86820 ccctcacact ccggcacatt ccacagcctc tcgtgagtcc ctcacctggc caggccagga 86880 ggagggacag cggctccagc cacgctcctc tggccgtggc caccgagcat ccttttgtgg 86940 aagtggcggg tggtgaattc atgaagagac catagagtcc cagactcagg ttgtccagca 87000 ggaggctccc ttttccccgg ctgcagtgag gcccctgccc gtgccagcct ggggcaggga 87060 gtcggcgaga ccttggggat ggagggcctc caagtcccta atccaggcac tggtgagaac 87120 tcgagtccgt tccgaatgga aaatcaaggc tgcctgctcc tgggtccctg catgactgtg 87180 gccagcgtca cggcagttat cctgtggggt ggcgtttgtg aagtgaactg agcagcagaa 87240 ggcctttcag accaatgatg ggcctttaag ccctgtagtt gtgaggtgtg aggccgctcc 87300 tggcacagag ccccagggca gtggggcttg gccagcactt tctgaggcca catccttgtc 87360 aggtcgtgtt gcgatgggtc aggacagatg attgacaact gtggcagagg gactgtggcc 87420 aggagaagac tctgcccagg ggtggccggg ccagagtccc cattggcatg gtcccttgag 87480 cacgtgcaca cacacctctt tccatgaaca gatcttttct gaaggctgcc gcaccagccc 87540 tccctgggga cctggatgca gcagaaaccc tgtcaaggga cccctgtgat ggtggctggg 87600 ctgaggaggg agcacggccc tgcagggcct gagcaggggc ctccctctcc ctgcagtgag 87660 tctggcgggc ttgcaggagg aggagatggc atcgtgctag ctagtcctgg agtcagctgg 87720 cctgcctctg ggagtttccc catgctcgga aagatctggg tctggggagc ccatcagctt 87780 gggctctaat ttaggagctg ttttctgggc attgctgtgc cattggtggg gccgcaacat 87840 tcacccacgc actcattgat ctttcacgtg tgactaagac actcatgtga gccacatcct 87900 gtgggattaa aggcaaaatc aggaaaagtc tgtccaggtg ggtcagagcc tggccaggaa 87960 gctcattcac cctctcatcc ccccctcatt ccccctcatc cctccctcat tccccctcat 88020 ccctccctca tcccttcctc ataccctcat ctctccctca tccattcctc atctcttacc 88080 cttccccatc cccttatccc tccctcatcc cctctcttcc ccatccctcc ctcattcccc 88140 ctcatccctc cctcatccct tcctcatacc ctcatcccct tatccttttc tcattccccc 88200 tcatcgtctc gtccctccct catcccctca tcccttatcc cctcatccct tatccctccc 88260 tcattccccc ttatcccttc atccctccct cattttccct catccctcat cccccctcat 88320 cccctcattt caccctgtcg tccctcaccc ccgaactcct catcccctta ttagctcctc 88380 ccctcattcc ctcatctcct catccctccc tcattccctc atccatccct gatccctccc 88440 tcatcccctc atacccccct catcccccat ccctccctca ttccctcatc ccctcatttt 88500 accctatttc ctcactcaat tcctcctcct ctcacccttt cctcccctca ccccctcatc 88560 ccttacctcc tcgtccctgc attccctaat tccctcaccc tctcctcccc ttacgcccta 88620 atcatgcctc ccttcattcc ctccgcccct cttcccttca ttttttcctc ccctctctcc 88680 ctcactcctt caccccctca tttcctcatc ccctcctccc ctcattctct cctcccctga 88740 tccccttctc ccttcatccc tcctcccctc atgtttcatc ccctcttccc ctcatgcctc 88800 atcccctcct cccctcacgc ctcatcccct ccaccgctca ttctctcctc cctttatcct 88860 ctcctcccct cctccccaat ccctcatccc ctcctcccct cccctcatcc ctcctcccct 88920 cattctctcc tcccctcctc ccctcttcct ccttccctcc tcccccatcc ctcatcccct 88980 cctcccctca ttccctcctc ccctcattcc ctcctcccgt catcccctcc tcccctcatt 89040 ggctcctctc ctagtctcct cccctagtct cctcccctcc tccccccatc cctcatccct 89100 cctcccctcc tcccctcctc ccctcctccc ctcctcccct catcccttac cccccaatcc 89160 ccatagcaga cactaaccaa gcaggctgtg tcctggccct gtggcacagc agtgatgggg 89220 actgctggcc ctggttctgg agccagagtc cagcgacagt gtcagccagg gcgaggggga 89280 ctgtgggggt cttcccagtg gggagggctc accaggaaac agtgagcttg cctgagctgg 89340 gggcacaaaa ggagcccatg agcagaggtg gaggggagag tggaaaaggc agctcccggt 89400 cagggccgag cccctgacct gcactgcctc tgaggccaga tctggtctag gattctcctc 89460 ctctgaggac agcgacctcc agggccacgc tgtctggtgg aggtggtggg gagcagtgac 89520 atgctggttg tctcccagct ggcacaactt caggggtggc atgcggtcgg ggcaccagct 89580 ctggctgtgt cagcggctgc agcccagcgc tgctggtgga gccagggcca gagccgcatc 89640 cgatgttgct caaagtccgt gcattcctca agcctgtggg gacaggatgc agctgtctcc 89700 agctgcgccc ccaccccctc cctgcctctg tttagtctgt gcctggcatc tggcatacct 89760 ggcatctggc atgcccacca tcctagcccc tatgtctaag tccttggtgg gctttgaaat 89820 ccagctgcag tgggccctcc tccaggcacc ttcctgactc cacccacctc cttctcacta 89880 gcctagctgt aaaatctctc ctgtctctgt gtggatctac tgcagatttg ccctcaggcc 89940 aggtttcgag ctttaaaggg caacatcagc cttcccagct gtacatttcc ccacaggaca 90000 gagcccaggg cagggctcag tcaggccggg agggagcctg cagctgccct cagggggctt 90060 ggagggtggg gccagtactg accaggactc aggctggagg tggagaggct acagagcagg 90120 ctcatgctgc ggccctcagg ggtgcctggc ccagcctcct ccagttggct gggccctgtg 90180 cgaatgctgc atccagcttt catcccagag acagatgggc tgcctgtgtt ctctgctcca 90240 ttcttgggct gcttggtgga tggtgccaca tgactgtgtt gtgtcatgtc cagatcctgt 90300 gaaccgtatc cctgaggtcg gggttcaagc acaatcccct gctcttagct gtgtgttcac 90360 atcggatcaa gtctcctgct gggatcatgt tcccttcggg cgaggagggt cagccctggc 90420 tgccatctgt ggcctcagcc tgttagatcg cctccctgga gaacctgggc ctccacatct 90480 gggttgcatg tttcctcttg tgatgattct gagggtttgg gtgctgtcac gtgggataga 90540 gtgagggagg cttcagggga cagggcctgg agcaacctcg tgcctgctcc tggagtgggg 90600 gtcctggagt ggtctccaag gccctcccag cccacatcct ccagtttttg ccatggcagg 90660 gtgatcttgg ccacctctca gcctccctgg gtcttggttt cctgctgtat gatcacaggg 90720 cacccatcag tggttcccat gctgtgccct gcaagcccgg tgggccccaa ctggcaatgt 90780 gggtcccatg tgggtcctgt gtgggtgagc tgctactctg ccagcctgct cctccctgat 90840 ccaccagctg ttgtctcctc taatctcact tgggatctgg gtaagacttg tcctcccttt 90900 gtagaggctt gaggggcata gggggactaa ggagtgttgc cagggaccct cctggcccga 90960 gattccaagg tctgctgccc gtgaccaggt ggagccaggc aggatgtggg ccaagggctg 91020 gttgcgaggc atttagggta cagctcccct gggcagagtg ggaagcctct ggggctgacc 91080 agcagtttgg aaatgaccca ggggcagcac catggctgtg cccatgtcag accctggtcc 91140 ggctagccat cttggcacct gggggagggg acagtggtct ggaaagggcc catccctgct 91200 gtgcacacag tcctgtaagg ctccctccca ccattctctc cccagctcac aggtgagact 91260 ccaccacagt caggttctca gagagattct agtccactgg ggtctgagca gggcaaagcc 91320 acatactacc tgaactgaga aattctctgc taggaccccc aagggggctg ttgtgggcct 91380 catgtggaag tgggttcatg ttctacttac agctccaggc ctggctccag cagagtccac 91440 ttgctcctaa ggagcagccc ctggctgggc cttggagtcc tgcctgcctc actgggcttg 91500 ttcctttgct gtgtcccact caggggccaa ggagccccag gatggggcag ggacgtggtt 91560 cctgatgaat gaggagtgcc tgggctggga ggacctggtg ctctctgaag ggcacagaga 91620 agggagtagg tgctgatgct gggaaagacc tgctggttct gatcctgggg cccaggggtg 91680 aggggcaggt gggctgtgtc tgcacacacg gagatggaag agaaggaagg ggaagagaag 91740 caagctgagg ccctttaggg actttggagg cagaagacag agggtccagc acaggaccga 91800 atgcttgggc ccagcaggag agacagggct ggtgggacct gcaggctggg tcttacccag 91860 tgcatagaag taatgaggat gctagagtgt actagatagt gacgtgtgcc agatagttac 91920 actgatgtgt accagacagt gatgatgaca tgtaccagac agcggtgctg acgtgtacca 91980 gacagcgatg ctgacgtgtt ccagacaggg atgctgacgt gtaccagata gtgatgctga 92040 tgtgtacaag ctccaggctc tgttctcatc gtgctctagt attagctcat ttaatctgca 92100 agacatcttg aggtaggggc aattactgcc ccatggtact tacaaggaaa tggggcacag 92160 agctgttggt gacatcctga ggccacacag ctgtgaagtg gctctgtggc attccagcgg 92220 tctgaggcac ttgttccagg ccaggctgca gtggctccag ccctggcctg caggcctgac 92280 cctccacagg atcctgcaat gttccaggag aggagcaaat ccctccaggc ctttgtcctg 92340 gcttctgggc atccacctgg cccagctgag gacagacgca aggctctcac tgcagacccc 92400 agggaagggg gtgtctgcag ggccagggcc aggggctcca cctggggctt gcaccccagc 92460 cctgtgtgca gcgagagcct gggggccgtg agatccggcg tgcacctgcc gaactcttaa 92520 gttttctgcc ctgggccttg tgccggtgct tgttctgaca tctccatttc ttctgtatgt 92580 gtacgtgtgt gtcctggctg cctccacctt tagcgtttca ttgggaaatg acactaggta 92640 cagctcactt ttctcttccg cccttgcttg gtctgtcctc ttctgctctt ccgagttcct 92700 ttctcctcgg cgtctgcctg cttctatgcc ctttctctga ccacccgctg tcctcactct 92760 cccaggattg ctcctcggtg acatgtgtcc gacagcagcc ctccctggtc cttctgcttc 92820 cttccacacc cccgacttgt gagatccatg ccctgcgtcc cagaccatgt gtgcagtaga 92880 cagggcagcc tggtgccacc tgtgctccac cgcggtctcg ggaggggccc ggccgccttg 92940 gagcctgcgt ggccgcccag ctgtgtgtgt tgatgtctct gaactgtgtc cttgcgagga 93000 tgcttggagg ggagctgggt gaggctgggt ggatggtggg gtgggcgagc tgaacgtgct 93060 gctcagggtc tgcagagtag ccacattctg gagtcaggca aattgtccac ctcgggtatg 93120 accagtcctc cctgtgagca ccaggcctga ggaagtagct cagtcactgc catccagaag 93180 gctgaaaaca ggaactctca cgtaacagaa aaccctgttc cggagcagag ggcacccaag 93240 gtgtttgcgg aacgtggttc gaccccatgg ggatgtaaaa tcccaggccc ctggggctgg 93300 ccctgagcca ccctgggaca gggtttgtgg gtggctggct caggccgtgc tcatcataac 93360 tccagggtgg agattaggaa cacagcgagg ccgccgctgt ctcccgtgtg ctaacagaga 93420 cgcttttgca cacggccttg cagcagccac cctgcctcca tgccaagcat cctccccccg 93480 gggccttcct cttcccaatg gaccaagggt gagtccattg tcagaggaga tggaccatgg 93540 aggtttttgg caaacccggg caggtcccct tcaggtccag ggagagatgg tggcgcctcc 93600 ttactcagac tgaggctggg gtgggcccgc gcaggctctg ccctctccct ccctgcctct 93660 gtccttcctc tcctccctgc ctgagtcctc tcctcctgcc ctcccctctc ccttccctgt 93720 gttccccaca tcccagctcc ctgtcctgcc tccctcctcc cttccctctc tgcccttctt 93780 gttctcattc cctgccgcct cctctccttc cagcctcagc gtgacagctg gggcaccatt 93840 tgtggtggag ctgggaaaat gctgggctca ccctcatcgg ggcgtccaag agaccctact 93900 ctctgggtcc tgagtaagga gggacctgtc cttcctggca ccgccgcccg ggcttccagc 93960 ctgtgccccc agccgctccc ttgcggctgc cccttgtctg tcgctctgtc tgtctgcatg 94020 tccccggcct ggctgaaagc agcccccacg ccatcaactt ctactttgtc tctgcttcct 94080 ttcaggacct tttaccaatt tgaggctgcg tgggacagct ccatgcacaa ctctctcctg 94140 ctgaaccggg tcacccctta tcgagagaaa atctacatga cactctccgc ttatatcgag 94200 gcaaggcacc tatgccaggg cactccacca aaaccactca gcccctgaag cttgaggttc 94260 ttgtaagctc tggacaaccc catatgaccc agacgacttc tctagttctc aagtccctgg 94320 gttaaatttg tgtgcctttt aaaaaacaaa aacaaaaact ggactgcaag gttgaatcca 94380 taaatccata aatccatgtg ctgttttttt tttgtttttg agaccgagtc tcactcttgt 94440 cgcccaggct ggagtgcaat ggcgcagtct cactgcaacc tccgcttccc aggctcaagc 94500 gattctcctg cctcagcctc ccaagtagct gggattacag gtgcctgcca ccacgcccgg 94560 ctaatttttg aacttttagt agagatgggg ttttgccatg ttggccaggc tgttctcaaa 94620 ctcctggcct caggtgatcc acccacctca gcctcccaaa gtgctgggat tacaggtgtg 94680 agccaccgca cccatcctcc atgtgctttt aatggcagtt aactcactct accatactta 94740 gtgtgtgggt gttgtccttg ggatgcaaga tggctgcagc accaccagac attgtgtctg 94800 cattccgggc agcacaaaaa cagaagtgtt ccatccccac agcaccccca gagtctgcag 94860 tacataggcc gtggccagac ctgggctgtg gcctcccttc caagtgcaag aggtgactgg 94920 aagtgtgggc gtttcttgct ggtcatagta gtgagggaga gggagggtgg ggagcagtgg 94980 gcaggggcat ctgcaagcac atcccctctc cttagttaca gccgaattat tccagcttca 95040 catggggatg gtgtgaccat ctcaccagat ggtggtgagg ttgccgtgag gaggcgctgg 95100 cagagctctt cccagcgagt gcttgggact cttcagccat gcacagcagc tgcccccact 95160 tcaggaagac aaaggggcca gctgttcagc agttagcgtg tcatccacca ggaagtcatt 95220 ttctgtggtg tttgggttaa aatgtgcaca ttcaaacaag acctggtttg atcctcacag 95280 acattccagg gtcggggagg ggtcacccca attttatggt gaggcagctg aggcccgagc 95340 agtgagccta tgtctgggac cctcggggtc cccacacatg gagaccagtc cctcaggcag 95400 cccaggggtg gacagagctg tggctacctg tccccagtgg ggttttctcg agggcaggag 95460 cagagacttt ctcctgcctg cgtccaggcc acacctgagg ccctgggaag gccctggggc 95520 tgcctgtcgg tgctgggcat tgtgccccca ggagaaggct ggaagggcac ctgggcactc 95580 ggggtgtcct tgtgcctgag tcctgctccc gcctatctca gatggagaac tgcacccagc 95640 cggctgttgt caccaaggac ttctgcatgg tcttctattc ccgtgatgcc aagctgccag 95700 cctcgcgctc catccgcaac ctctttggca gtgggagcct tcgggcctca gagaggtaag 95760 ctcccagggg tgaggaccac atggactccc accctggtct cggtgcgggc caggcagggc 95820 tctgcctggc agcggtcctt gggccacccg gcagctcacc ctgtgcgagg cccagccaca 95880 ctcctggctg gctccctgcg ctcagtcccc tcctgctcac cctagatgaa gactctgtgg 95940 aggccatggt tcctgcaggg gacactgaca ccactatgag ggacttgagg gccagcctgc 96000 agcggatggg aggaggggca ggcccagggt gcccacctgg ggcctcctgt gggtgatcct 96060 ggggccacac cgttcccccc cccccccccc cgccgccggt gaccttcttc cctgaggacc 96120 acggaacctg tgccatggga ctgactgccc acaaggcact gaaggaggag ctggataagt 96180 gggcggtggc tggaaggggg ctctggacac agcttcccac aggacctgct gggtggctct 96240 tcttggaggc tgtcagcacc ttggggagcc acacaccgaa caccaggacc agccgtgctt 96300 gcgtgctgaa cacgctcctg attcttgggg gtgggggaga atgagccgga atgtcagggc 96360 cctgacagca gggctgccga ggctaccggg cacccgtggc caccttcagt gggtctccct 96420 gtggtctgcc acatggacct ggtgtccagg ttcacactgg gcacagctgg gaggaaagag 96480 cttgggggtc aggatccagt gtccttgagg gctggctgtg gtcattctgg aggtcactca 96540 gtaattgtgg gatgccaccg acctgtctgt gggagggtgg ccgaggtgct ctcagaatct 96600 gtccggggca cagtggggct gctctgtggg gtatggggcc tgaggggctc tcgacgccgt 96660 ggagggactg gagatgccag atgctgtgct catgttgcct gtaccccact tgggctggga 96720 caaagtggag gctgctgtgg gggcctggcc tcacgtcaca gccccatggg cacctgagca 96780 agaccagcca atgcatcttt tctctggggg ccggagggag tctgggatga ggactctgaa 96840 caggggctgt agctcaggga cctcaacacc ccatcacccc agccaggctg actgtgcgtt 96900 tgatagtggg gcaagtcagc agccaggctg gctgtgtgtc cctgttgcgg ggcctggtga 96960 ctgcatgtca ctccttctac tccccacagt aaccgtgtga ctggtgtgta cgagctcagc 97020 ctgtgccacg tggctgacgc gggcagccca ggtaggtatc tgccctgctc tcactgggtg 97080 ggttcctggc ctgctcaacc tctgcccact tggggtgacc acagcgaagc tgccatttgc 97140 agggggatcc ctcacagaac ccaagcactc accttgtggc ttctggagtt gttctgagat 97200 gggaggagag cgagggagga gagtcaggcc tgctggcttc cttgggttcc cagggcacag 97260 ccgagatggc catgggacgc cgggctggat aacttcctat ggaagaggcc tacatggctc 97320 tttgggcccc agggtggacc aaggaccagg ggaagcccat ctccactcca gaggggagac 97380 agcttcacag atgggcggac ctctaggatg ggtgggagga gcagccaccc atcaggtagg 97440 ggtggaatgt ccacgtgccc catgcaggga tgcagcgccg gcgccgacga gtcctggaca 97500 catctgtggc ctatgtccgg ggcgaggaga acctggcagg ctggaggccc cggagtgaca 97560 gtctcattct ggaccaccag tgggagctgg agaagctgag cctcctgcag gaggtgaggc 97620 agcctcagag gatgaggccc gcacggtggt gtccatgtgg ctttgtgtgc agagcaaaag 97680 ctggagaggg cccagggcct ggtgcctact ggggggcagc acagctgctt gggagtcaca 97740 gccacctgca ggaggagcat gtgatgctcc agtgtgcact gcggggctgc gtggtgtatg 97800 acagaaacat ggccagtgta gcacagaggc atgctctgga attagccgag gaagactatc 97860 gggcatatag acagaggcca gaaagggacc cggaaggaga gtcgcggggc tgggctgccc 97920 tctgcggctt tgatcaggga aaccaacatg cagcatctag gcactgcctc gggccgagtg 97980 tgtgtgtgac acgtgacgcg tgacgtgtga gatgcgtgag gccagggctc tgcccacccc 98040 tcggccctct cctgaggcct ccagcactgc aaggcagcac agccctgccc cagaacctgg 98100 cgcgtgagat ggatgtgtct gagaggagca gcttgcttgc tgcccatgaa ggtggcaggg 98160 ctggggtggg ggctgagggc tgtcagcccc ggggcgccag ggtctgttcc ctcatttcac 98220 agctgagggc tgtcagtctt cagtcttagc ccaggggagg gtgggctctc cggggtctgc 98280 ccagagggtc atgctgctgc tgaggctgag cacaactccg gaggtcaccc ctgaggtgca 98340 gcaggtaagg ccttgtgtcc tgtctgaagg tggagaagac taggcactac ctgctcctgc 98400 gggagaagct ggagaccgcc cagcggcctg tcccggaggc actgtccccg gccttcagcg 98460 aggactctga gtcccatggc tcctccagcg cctcctcccc gctctcggct gagggccgcc 98520 catcacccct ggaggctccc aacgagaggc agcgggagct ggccgtcaag gtgggtccag 98580 ctggtgggca gtacagccgt agccccaggc cctcaagggc cctgagtcat ttctgggcaa 98640 ctccagcaac ccggccttgc ccatggctgc tctggttagc accaccagga gctaggagct 98700 tgaggggtcc ctagggtccc cttgcccact gactgcaccc cacctgcact gaaagttggg 98760 tgccttttgc agcctccctt cccaagcgat gaatcactct cttgaatacc tgtgctgatg 98820 gggagctcac cacttccacc cacaagtggc tcttttggcg gctgaacggg cctctgggaa 98880 ggcttcctgc gcctcctgca ctggaggcag cacagcctct ggccctcaca ccaggccctc 98940 agccggtgcc tgaccctggg agacttcctg ggctcacccg atgacctggg cggggtggag 99000 gtgctgccca ccttgaccca ctgtgctctg gcgtcggaac ccacctgtgt ctggggaggg 99060 gtgggtagaa gagcctgcaa ggctgtctga gcagggtccc gggaggcctg gcccctgacc 99120 acgcgtgtgc tctgtccaca gtgcttgcgc ctgctcacgc acacattcaa cagagagtac 99180 acacacagcc acgtctgcgt cagtgccagc gagagcaagg tgggtgcaga ggggctgcac 99240 caggctgccc cgcagggctc gggctcccat aggcagtggt ccctgaggaa aactcccatt 99300 ccaagtggga aaaggcagtt aagagtttcc taggaacacg tctcagtgca gagggacacc 99360 tcatacctaa gtggctggtt tccctgggtc ggcctggggt ccatgggagg tggggatgtg 99420 agtgaggggc cgggtgggtc ctgtggcctt ggatgcaccc atgcacttgc aggcttctgc 99480 tgtcttcctg gcccccaccc tgtctggcca tcaccctgtg gcctctggcc cagtcagtca 99540 agctcccact tggctgtccc tcctcctcct gggaccgacc ccacccctgt agcctgggaa 99600 actgctgctg tgctgcatta tgcgtggagc tccagccctg gcccatggcc ttccttgtcc 99660 ccatggcatc acccagcgcc acctcacgct ggcatgggca ggaggcggca gggcagagct 99720 tacccagccc actcctcgag gcattggcag ggtggctgcc tgggtcaggc cagagcctga 99780 agtgatggga ggggccggcc aggggccaca ggggctggag ggggccgggg gtcttgagct 99840 ggccaacttt gagccaaggc tgctggtagg aggggtgggg tgccctaagc agcaggtgtg 99900 gggtaagcgc aggcacaggg agcagctccc acagaggccg gagacccccc ttccctgtgt 99960 cccctgaaaa aggcctctcc tccgcagctc tccgagatgt ctgtcaccct gctccgggac 100020 ccgtcgatgt cccctctagg ggtggccact ctcaccccct cctccacttg cccctctctg 100080 gttgaagggc ggtacggtgc cactgacctg aggtgagtga gctccaggct cccggagtgg 100140 cttctggcac cacggctgac ccatgaccat ggccgtgact cgggcacaga gagcacagaa 100200 cagggggccc caatggccga gtgccttggg gtggccacag gctgagggaa gggcctggag 100260 gagtggagtc cgcagccctc tcagagggtg cctgtgcccc gccagctcca tcctagtgtg 100320 tgtgtgttct cttccctgaa gaagaccaga aatgggtgga aaataagcta aagctcccct 100380 ttcctgagac agtgcttata aaataatgga aaaagaaaag gttacgaaag agggcatgag 100440 agccgttaga gtcagtattg tggaggggac acctggcccc tgcaggtccg catttggaag 100500 agacctcgtg tgaacccctt atgtacaatt cataagcagg cagatgcttt tcactcttgt 100560 tttaagcgcc ttaagggttc cagattttca tttaaataag aaagacggtg gcatcagctg 100620 gccttgtctt ctgcaggcct ccttgaccac caggtcgagt cgcgtggggc ctggcccatg 100680 tggggggccc atgcgggagg ccatcggcac cctctgctcc agtggctcct tggaacctcg 100740 tgtcaccttc agtctagttg tggagatgaa gagatgctgg acttgctttc acagggtgga 100800 ggtgggggca ggagagccac tgggagaagg gcgtggagtg gggcacaggc tccctggctg 100860 ggccccgagg ttcctggggg accctgccca ccaagcccag cacttcctgg aatcgggcac 100920 aagcttggct atcctggtgg acgggccccg ggagctccca ctgtgggcac agctggagag 100980 accctgcgaa ggtgccctac tgcaccttct gaggtgctct gaggagggtg aagcctgggg 101040 gaagacggcc ccaggcccag ggaggcctgc agtgggcagc acttccctct gcttcccagg 101100 accccgcagc cctgctcccg gccagccagc ccagagcccg agctgctgcc agaggccgac 101160 tccaagaagc tcccttcccc tgcccgggca acagagacag acaaggagcc ccagcgcctg 101220 ctggtccctg acatccagga gatccgagtc aggtgtgtgg ggcctccctg gaaagcaccg 101280 ccaccagctc tgtgctgaca ggggacaggc aggccaccct gctccccata ctgggggcac 101340 agggaccctc atacttgggg agacagacag gttgcctgat gcccatactg gaggttcagg 101400 caggctgccc ctgacccaca tggagggaca gctccatgct gggaggtcag gcagggccct 101460 gtgacccaca tgcctaggct gggaaccagc acagagcaca ggggagtggg tggggtcaga 101520 gccaaggccc aggtggggaa ctcgtggtca ctgggtacag tgtgacagcc ttcagcaact 101580 ttagcttatt tctttaagtt tttccatttt atggtgggga aactgaggcc cagagctggc 101640 ttggtggtct ggtctccggc ctgctgggtt ggggttctgc caggtgccct tcgatgcctc 101700 gacccacttt ctggctgggg aggtggttgg cactgctgcg tcccagctct gggtggtaga 101760 tggtgagtgc ccgagtcagt cgctgccccc accgagggcc ccagcgagca gctctctctg 101820 ccttcagccc gatcgtttcc aagaaggggt acctgcactt cctggagccg cacacgtcag 101880 gctgggccag gcgcttcgtg gtggtgcggc gcccctatgc ctacatgtac aacagcgaca 101940 aggacaccgt ggagcggttc gtgctcaacc tggccactgc ccaggtggag tacagtgagg 102000 accagcaggc tatgctcaag gtgcggctgg gcccggctca ggctcgggca ccaggaaccc 102060 tagcagggca ggagctgagc caccatcctc tgcagccctg cgtcagagca ggaggcccat 102120 ctgctcaccc cagactccgt cctgttccac ggaggctggg ctcagggact cagcctcagg 102180 gatcctctgt ccttgcccca ggcctctctg cctgcccatg aggcgcatat tcctggtgac 102240 agctagtggg gatggactcc ggtcagggca agcattagta ttctcctgtg tgatggccac 102300 agccatgtcc cctcctccgg agtcacccaa ggtgggtggc accagccctg caggaatggg 102360 cgagccacag ggctcagagg agccctcctg cccccactct gcccagcccc tccgtctgga 102420 atggccctgg acaagttcag gagcctggac tccttcaggc tggctggagg agaagtttct 102480 ctgagccatc tggaggcggc cccagtgtct acgagatggt tttttgattc cctgtggtgg 102540 gagtgggtgg tgtgaaccca catctgcacc agcagcccag ccagggtccc agggagcagg 102600 ggccatgagg ggcagtcacg tcccgtgggg aggcatagca gtggtgaggg tgtcctggga 102660 ccaccggccg cagatgcgtc cagaaggcag tcacagccct ggctgggtca gccttcccct 102720 ctttgtcccc tccgtgtccc ctccctggga ctttcctggc agtgcccctc ccctgcctgc 102780 ctgggccctg gggagcagga gggtggtgtg ctgaccacgg agcctggcac ctcctcacca 102840 gctgcctccc tctgcagaca cccaacacat tcgcggtgtg cacggaacac cgcggcatcc 102900 tgctgcaggc cgccagcgac aaggacatgc atgactggct gtacgccttc aaccccctcc 102960 tggccgggac catacggtag ggccgcctgc agggcgaggt tgctgccatg ggggtcctgc 103020 cctcaaccgg ctcctggcca ggaccatttg atagggccct gctgcaggac aagactgctc 103080 tcccaggggt cctgccctca atcccctcct ggcggggacc attcagtagg gccagccgca 103140 gggtgcggtt gctctgccag gggtcctgcc cgcaaggctg cctggggaag cagtgcggcc 103200 agtggaaggc agcgcggcct gccctcactt atgtgggctg gggatgccct tagggctatt 103260 aatgctccct ctgagttgtg gcttcttgtg gagtgataaa tcccaggcca tactttcaaa 103320 attacatcct aacccggtgg cctcggcatg gggaaaccgt gtgcccttgg gcaggctgcg 103380 gaaggagctg gtccctccca cagcagggat gtgaaaagcg gggtgcagga ggggatgggc 103440 gggctgagtc ctacacacca gaagcagaga ttcagtccct tccccaggtg gtgagggaac 103500 cagcggggac atggggtctg tggctgcccc tcacggctgc ctgcctgtgc agggcacggt 103560 ggatatggcc tgcaggtgtt cctggcctga ccacgccgcc tctcccaact cttctgcagg 103620 tccaagctct ccagaaggag gtctgcccag atgcgggtct gaacctgagc cctcccgtga 103680 cagccggcag gcccagccca tcccctccct catcctcgtc tgtcctgtca cctgccgccc 103740 agcccctctc ctgccagaca gcccacgacc gggtcgaccc cccaggggac gcccatgcca 103800 ggcccgggga cctgtgccac acgaccagct gtgctcccag cagaggctgt gcgtgtcagt 103860 tcttcttgca gaatgtgctc tggtggaaca agttgggaga ggctgggggg gccaagggca 103920 caggttacgg gggttcttgc tgccgttcta atattttttt aagcatagac agacttataa 103980 ttaatatacg ttagttagtg acattgaaac agtcaactcg gaaattaact ataagacttg 104040 ttctatttat aagtatttat ttctaatgcc tccacatagc cctgtaatat tcagatggaa 104100 cccccaacca cctccaccct gtttgttccc acatgtgtct cccaagcctg ctagggacag 104160 gcagggcagg gacagccacc ttggaaggcc gcagtgagga gctgtctgga ccagtggggc 104220 accttggggc tagcacacgg gtgtatcgcc tgggccccag gcttctccat ggccacatgg 104280 gtcctgggtg tatgtgtggg agagtggggg ggtgtctttg gtgcctgaag tctgcgcggc 104340 atggagggtg gtgtgagttc ctctggtggg agggagaacg cacatctctt ctgggcggcc 104400 acctgaggag tgactccaag aagagttccg gcagctttcc ccaggaaagg gtgaggggtg 104460 acactcggct ctggctctga gatgaggcag acggcaccca ggctgtgatc tgtcctgggc 104520 ggggaccagg agggagcggg gtcgggatca cctgccagtg tgcagactct gggactgcgt 104580 gctgtctccg gaccatcagg gtagggtggt gggttgagac caggaagtca gggaagatcg 104640 gaattcaggg cgacggtcta ggtgtcgagg gctgtggcgc agcctcttca gctgcggcga 104700 gaaatggagt gagtcaaggt agcttctggg aagaaatgct gccattagca ggtttcttgc 104760 aaagactttc ctctctttgt tcccagggca gagagtttct gtgagtccca ctgagaaaat 104820 cccatggggt gggggtatcc tggtcggtcg gcaatggagg gtggctggct tggtggttat 104880 tgtcttcaag gagctcttcg ctgctgcatc tgcggtgtcc ctttgttctt gtcccatttc 104940 accccctctg cagacaccaa tgtccgaggg ccacccagga caggacgggg gtcagcccca 105000 agctgagagt ctggtcatag gagtcatgtc cagaggccta gggaggtttt agggccctcc 105060 ccacccacac ccacaggtcg atttggtctc tttttagctc aaggaaagac agtagccaag 105120 caacagagcc cctctcccgc cgtggcccgt gggagcagtt acatcgggtc tggtgctcca 105180 gacctagggc ccagcacttt catcagatcc tgcctcctgg agtgggggaa acgcagcacc 105240 ccactggttc tgaggcccct accctcccag gctgtcccac gtgatgctga catgagcctc 105300 agagacccca atcccatgcc tgggggagag acagcggctc aggagtgggg gagcacgggc 105360 cttctacacc acatgggaag gctctggcat gaggttttcc tttgggaagg ttgtttgggc 105420 ccctgaagtt ccatctccga gagtggtgtg cagggcaggc cagggcccat gctggctgca 105480 gtctctgtgg ctgcctgcct gggccagcct gtttgggagc tgggactgtg ggctcgcctt 105540 ttcgtacctg ggctcaggtg cggtgtggcc accgccaccc tcatcccctg cctgggaggc 105600 tctcccaggg gctgatgggg gggttctgtg agggagaatc agggctcggg aagccacgcc 105660 tgggaaggca ggacacagga cacagcagct ttctttggaa atctcccagg tgaggattca 105720 catcccaaaa taaaattcag aagccaggtg gcctgtgctc cccatgggtg acctctggag 105780 gcagtggacc aagatgcagc aaggagagga tgcagaacag cttcttgcag aagcacctgc 105840 tccggcatcc agcgctgcct ggaggcagga aggagaggca gggcaggaca cgctggtctg 105900 agatgagggg gagccccacg ggccccaggc aggctagagg aggcacaggc cctgccacgg 105960 ccaactcagg tcagccagcc tgaggctgtg gcctccaaag ggtctgggcg caccccccag 106020 gtcgcaggtg tctgaggcca gccaacctgc agagcactcg cggcgtgggt gggctgagtg 106080 gaggtgcctg ggagctgcct aaattcagaa gcctccactg ccatggagac tgcctggctg 106140 tgtcctctca gccaggtgcc gtgttggcct tggctaggac ccagagccac actgcagcct 106200 ccgccgactc cctccttccg ggcctgctct agtgaggagt gcctaagcca ggacccagaa 106260 actcagagtt gatggtgaga ggaggccgcc tgagtcagga cacctggctt cttgaaaagt 106320 tcgctctgcc agaaaccacc tagggaccac gttagctgcc ttccttgagc tccccaggag 106380 tcggtttcca catctgtgag gtggagggct ggtgtggagg tgctcatggg gtgcggtgct 106440 tgggagacag ccaggcccag ggtggctgct gcttcctgct aagtggggga ggtgagacag 106500 atctggaaag ccgtctccct cagatggttt catttaatgc tttatactgc cgagtctggg 106560 ggcttgtttt ggtttggggg cagccatcct ccaccagaaa gggggagctc cttccgctgc 106620 ggctccagat agatggggat gccgggctcc aggccgacca gcacttggga tctgatggga 106680 cacggccagt gcctaggggt gccaagtcca aggcctccca ctgggagtca tcgctgagaa 106740 gatgccaatg tttcatccac cggctgcaca ggcacaaact cccccaccca ggacggctgt 106800 gatgaggtgg ccctccctgt caaccctggt ccctggagtc cccagcacct ggggccctgg 106860 tggggctgat gtcacaggtg tttactgtgc tgctgcactg gtcctatgcc agcctcaccc 106920 atgtggggac cacggaaggc acactccctt acccccggtg ccgggccgtg cggtccccca 106980 gacggacagc agctgtggcg acctgcgttt ctccctgggc ctgtgcttcc tgtagttagt 107040 ccgtcccctg gttcccctgt ggctcagagg ccgcgtccct ggcttgtaca tatgtgattg 107100 ctgtgggcac accccagacc ccatgtcata gctgccgtcc cgacgtcacg acgcctgtcc 107160 cgatgtctta cacccgagtg ttagccctag gctcctgtac tgtgcgtgca cttgaggctc 107220 tgtccaatta agaaataaat gtggctctta ctcaacacag tc 107262 <210> 5 <211> 43566 <212> DNA <213> Homo sapiens <400> 5 cccgagcgcc ggccgggcca tgacccccgc tgctctgtct tgcaggctcg tcgccgcggc 60 cccccgagcc cgaccgccgc cgccaccacc accagcgccc gggcgggcct cgcgcgcctc 120 gggcgcggct ccgcagtgag cccaccaaga aggaagcggt gagtgccccg cgcctcgtgc 180 ccgccgcccc ttccccggga cgcccgcctt ccccgagcaa cgcggccccg gccgggcggc 240 gtccacgcct cgcaagctct agccgctgca ggggcgcggc ccgggggtcg gtgggagacc 300 cacgcgggcc cgggcgtccc cccaacttct tgcagacttt gctgcggaga cacgggcttt 360 gggaaacttg gcccggctct ggccgcgctg caacttgcac ggcggtgggg gtgtgacccc 420 gcgcggaagc ctctggcccc ccactcacca caggccaccc cgcgccgtca cgagttcctt 480 gggaatggac cagaacgcca ttcctgagag ctggaaggca gcccggcggg gggcgggggc 540 aggaggcctc ccgaggaacc atttccactc tatcgagtat ttccaaatct attatttatg 600 aactgcctca cttaggggcc cccctgcgct cccagggcat caaagcaggt ttgcaaccgc 660 gaagggcgac ccgtgtggac gcacgcgctc cttctcctgg ctggctgcgc tcgagcggaa 720 ctaggggagg tctcagtaaa aaggggcacc cgcagctccc cccagggata ggcggagggc 780 ggggtctgag ggcggctggg acttctctca gaccgcctcc ggctgcgggg cccagatgga 840 atcaagggaa aatctgtgca ggctcgacag gctttggagc ccggaggaag agggaggaag 900 ggaaggctgc gaggcaaagg cacttgtgag gtagtgcggt tctcggggaa cgaacgcctc 960 aatgtacagg ttaggaaact gaggctctga gagggatacc ctgagtcaca ggctctggcg 1020 tttcctgcct agaccccacc catccaacgc tgtggggagg cccctgtcct gggctgggtt 1080 aactccaaaa agcaccctca cctgtgcagg ccacgccctc cttgggttct gcgcccccac 1140 cgctggggac ccggtcctgt ggatgggagg aggccgtgta tttatggaaa cacttaatcc 1200 ctcaccagcc ccaaggaggc tgaaagctca ccacctaatc tcgtctccct ggaagcgcct 1260 tcccatgccg gtggggtgca ccccagaccc acgtagagtg tattttccca gcccaaggtg 1320 caggtcacct ctggagactt gaaatgggag cgtgccgtca gtggacactg aagaagagcg 1380 cactgatagt tcatgcttac ggagcactcc tcatgcacca gaccctgcgt tttctgtttt 1440 aatcccctga ccaactctcc aaccaaatac tgtcagcccc attttaaaga tgaggaaaca 1500 gggccaggca cagtggctca cgcctgtggc tgcaatactt tgggatgcca aagcaggagg 1560 agtgcttgag gccaggagtt cgagaccagc ctgggcaaca cagtgagtcc ccccagctac 1620 taaaaatttt ttaatgagct gggtgtggtg catacctgta gtcccagcta cttaggaggc 1680 tgagacggga ggtttccttg agcccaagaa gttgaggcta cagtgagcta tgatcacgcc 1740 actgcattcc agcctgggca acagagggag accctgtctc ttaaaaaaat aataataaat 1800 taaaaaataa aaatgaggaa acagaagctt gtaaaggcaa agtcactgac acaaggttac 1860 atggctggaa aatggcaagg ccaggcctgg aaccctgagc cgtggtactg aattgctctt 1920 acctgcagtg gaagccaggc taggcctctg ggcctgctaa gtataatccc ccatcattaa 1980 aaagattagt aagtgatgat ggggcccagg cacagtggct cacacctgtg atcccagtgc 2040 tttgggaggg tgaggcacga gcatcacctg aggccaggag tttgagacca acctgagcaa 2100 catagtgaga ctcctttctc taaaaaaaaa taaaataaaa aaaaaaaaaa aaaaaaaatc 2160 aaagcctccc aatcatctga atggaccact ccccttggct aagggcattc cagagttaac 2220 ctgcaaagct agttcaggcc atgatgagaa gtggggtcag acatgcctca ttatactctc 2280 ttgccttttg aaattgagac cccgcagacc agcattaaca tcagtgcaga ccttcagact 2340 aataggacag tccctttaag tctgataaga aacatgtaca atctgttctc tctcaagcca 2400 aactccttat cgtaacccag acattccttt ctatggattc caggtcttta gataataact 2460 cttttgggtt tttttgttgt tttttcttga gacagtcttg ctctgtcacc caggctggag 2520 tgcagtggcg tgatctcggc tcactgcaac ctccgcctcc caggctcaag tgattctcct 2580 gcctcagcat cctgagtagc tgggattaca ggtgcgtgcc accatgcccg gctaattttt 2640 gtatttttag tagagatggg gtttcgccct gttggtcagg ctggcctcaa actcctgacc 2700 tcgtgatcca ctcacctcag cctcccaaat tgctggaatt acaggcgtga gccactgcac 2760 ccagcccaga taataactct ctcaaccatt tgccaatcag aaaatttttg aatcctccta 2820 tgacccaaaa gccatgtctc cccatcccac gtacttcccc cttcagttgt cccacctttc 2880 cagatgaaac caatgtatgt atgtgtatat atatatatat acacatatat atatatacac 2940 acacatatat atatacacac acacatatat atatatgtat atatatatat atttttttga 3000 gacggagtct cgctctgtca cccaggctgg agtgcagtgg tgcaatacca gctcactgca 3060 acctctacct cctaggttca agcaattctc tacctcaacc tcctgagtag ctgggattac 3120 aggcacctgt gccacacctg gctaattttt ttgtattttt agtagagatg gggtttcacc 3180 aagttggcca ggctggtctt gaactgctga ccttgtgatc cacctgcctg agcctcccaa 3240 agtgctggga ttacaggcat gagtccttgc gcccagctgg aaccaatgta tatcttgtat 3300 gtactgattg ataccttgtg tcttcctaat gtataaaacc aagctgtaga ccaactacct 3360 tgggcacata ttctctgggt ctcctgaggc cattggtcac tcacatttga ctcagaataa 3420 atctcttcaa atattttaca gtttgatact ttttgtgggc aagatgatat gcccattgta 3480 ataagtgtac atcaaaagtg tgcaccaggt caagaaagag accttcagcc ccccaggaca 3540 cccccagaaa tcccttcatg ctcctcccag ccatggtttc cctatgggta gccgttaacc 3600 tgacttcaaa tagcagaccc cttttattta ttttgagatg gggtctctct gttgcccagg 3660 ctggagtgca gtggcatgat catggctcac tgcagcctca acctcctggg ctcaggtgat 3720 cctcccaact cagcccccca agtagttggg accacaggtg tgtgccacca tacccagcta 3780 atttttgtat ttttctgtgg agacaggatt tcaccatatt gctctggctg gtctcaaagc 3840 cctcttattt tttgataaat gtttttattg atgtataatg tacagaaagg tgctcaaatc 3900 ctaaaggtgt tcagctctat tatttcacgg tggcccagag tcggcaatgg gcaagtattt 3960 tgctgtgagt cacacggctc atccgtggga ggccaagcag gtggggattt cggtgggcct 4020 cctgcctcca ccccatcctg tttcgcttcc tgctggtgaa ggcttcctgt gggccaggtg 4080 gaggtcctgg ccactcagag agggactcac tgtccccgca ggaccgtggc taagctgaag 4140 accaggatgg aagcacatga atgcttgcag tatcgcttcc caacccagtt cctttggctg 4200 gagttgtagg aattctaatc ctgctgcaga aagaaagtgg ctttcctaaa gaaggaagaa 4260 aagcaccatg tgtgtcgtga gcctgctggg agccccgctt gcccgcactc tcttccctgc 4320 ttgcagcatg accaggccca gagagctgaa ggggcttacc aagcctcaga gaccaccctg 4380 ccccactggg attggagccc actcacctgg caaacagtca cattcttcag ctgtgactct 4440 tcttcagccc tgccctcttc tgggtcctcc tcccaggagg tctttgttag gcaagcaggg 4500 caaggtgcca ccgtgactca ggacctccat ggggttactc tgatttcatc tgggaggtgg 4560 ctctgcagga accagttcat tcactttccc tgtctagttc tccaggtccc catctgggac 4620 agccagacgt tagaaatcag atgaccttga atagagtggt cagattcagc agataaacac 4680 aaggataact aagttatcca gctaagtttt tgttgttgtt tttgtttgtt tgtttgaggc 4740 gagtctcacc ttgccgccca ggcttgagtg cagtggcgcg atctccacta gctgcagcct 4800 ctgtctccca agttcaagcg attctcctgc ctcggcctcc ctagtagctg ggattacagg 4860 cgccctctgc catgcccagt taatttttgt atttttagta gagacggggt gtcatcatgt 4920 tggccaggct ggtcttgaac gcccagcctc aagtgatctg cctgccgcct catcctccca 4980 aagtgctggg atgacaggaa tgagccaccg cacccagccc cagctaagtt taactgcaga 5040 taaacaatga atagttttta tgagtgtgtc ccatgcaata actgggcatc ctgtatttta 5100 cctggccatc tctctctgac cacttccagc tctagatttc tatgagcctc tccaggatgg 5160 gtttatctca tagcctagag ctgaacttct gtgatccaca caagtggtaa ctgaagggaa 5220 tcggcaaacg ttggagccca ctttgaaaag cagggtccct ccagccagcg ggagattctg 5280 tgtctttgga aagcagggtc cctccagcca gcgggagatt ctgtctctgg taggcagtga 5340 gcagggtccc tcagtcagcg ggagattctc tgtctttgaa aagcagggtc cctccagcca 5400 gcgggagatt ctgtgtcttt gaaaagcagg gtccctccag ccagcgggag attctgtctc 5460 tggtaggcag tgagcagggt ccctcagcca gcgggagatt ctctgtcttt gaaaagcagg 5520 gtccctccag ccagcaggag tttctgtccc tcacagtcag tgctatgtct tggttgcttt 5580 tgactttatg aaagaacaca tcattttgct tttctgtttg cactgaaaat ctgtagaggg 5640 caagctgaca agcagtctgt tgtgagctgg taatttgtgg cacctgcctt caaggctgtt 5700 gcaaaaacaa acacagccaa catggaagtg ggacctgtcc ctggagatgc tcttggcctt 5760 agagaagctg tgtggcatgc atgacatctg atgtctgtct gtcttgccac ccctcaggag 5820 ggggtggacc tctgccgagg aagtcagttt ttataattgc ccattgccca tccttgtcac 5880 cagagagaat ccgtgaccat ttggcgacag ggagattttt tttttttttt tttttttttt 5940 ttttagacag agtttcgtct tgttgcccag gctggagtgc aatggtggaa tctcagctct 6000 ccacaacctg cagctcccag gttcaagcga ttctcctgcc tcagcctccc gagtagctgg 6060 gattacaggc gtgcgccaca atgcctggct aattttgtat ttttagtaga gatgggcttt 6120 ctgcatgttg gtcaggctgg tcttgaactc ccaacctcag gtgatccgcc cacctcggcc 6180 tcccaaagtg atggtattac aggcgtaaac cactgcaccc ggctgacgga gagttttttt 6240 tttttttttt ttttgagatg gagtcttgct ctgttgccca ggctggagtg cagtggcacg 6300 atctcggctc actgcaagct ctgcctcgtg ggctgacacc attctcctgc ctcagcctcc 6360 caagtagctg agactacagg cgcctgccac catgcctgac taattttttg tatttttagt 6420 agagacaggg tttcaccgtg ttagccagga tggtctcgat ctcctgacct cgtgatccgc 6480 ccgccttggc ctcccaaagt gctgggattt caggcatgag ccaccgcatc tggctgctga 6540 cagggagatt tttatgcctg ggtgcaagaa agaacctgtt cttcttcaag ctgttgtgca 6600 aataattaac aatctgatat ttcaacggga acataaacag agcccaattc aatatgaaac 6660 ggaagttttt cacacccctg caaatgtgtg aaaaagatag aacatttata cctaaactag 6720 cagttctttt gggcccaact gctcccatac catcatgcca agctaagggt atccttgcct 6780 taaatctttt tttctcccat taaatcttta ttttattttc tttttctttt cttttctttt 6840 tttttttttt ttttttttga gacggagttt tgctcttgtt gcccaggctg gagtgcaatg 6900 gcgcaatctc ggctcaccgc tacctccgcc tcccaggttc aagcaattct ccttcctcag 6960 cctcctgagt agctgggatt ataggcatgc accaccatgc ccggctaatt ttgtattttt 7020 tttttctttt gagatggagt ctcgctctgt cgctcagcct ggtgtgcagt ggcacaatct 7080 cgactcattg caagctccgc ctcctgggtt ctcaccgttc tcctgcctca gcgtcccgag 7140 tagctgggac tacaggcgcc caacaccatg cccggctaat ttttttgtat ttttagtaga 7200 gacggggttt cactgtgtta gccaggattg tctcgatctc ctgatctcgt gatccgcccg 7260 cctcggcctc ccaaagtgct gggattacag atgtgagcca ccgcgcccag cccaattttg 7320 tatttttagt agagacaggg tttctccgtg ttggccaggc tggtctggaa ctcctgacct 7380 caggtgatct gctcgcctca gcctcccaaa gtgctgggat tacaggcttg agccactgcg 7440 tccggcctta aatctttatt ttctagttac aaagatacgt gtgtttgtaa caaactcaaa 7500 caatctagaa ttctggcgtg tggaatagaa cactgcaacc cagtgcagtg atgtgggctt 7560 ggctttagtg tctggcagcc cagagctgta gcttgctagc cctgggtgct gggagtcgct 7620 ggacagctgt gagccccagc tcctcattta taaaacagga tggtgataat gtttatctct 7680 tagggcattg ttagggttca gtggcatcgt ttttatagca aacttggccc agaatttggc 7740 acactgaaaa cagctggata tctatcagct gatattgtca tgacgatgat gataaagttt 7800 aaggtaacag tggctcttcc ctatgtttag acaactgtat ggcttctatt cagacagatg 7860 tagaatcaaa gctgtaactc ctccttctca gacatttcag ctcatctaag gggcctctcg 7920 catgaaagca tctgtggtct ctgcaggagg ctggccccag atctcaaagg gagtggacag 7980 ggctctccac actcccacat aaattcaccc ccaacacaac aggccacact gtggaattgg 8040 ggccacgtag tgggggtgcc ctggtggtac ctagtggcaa tcacactgat gacgatgatg 8100 aggatgatga tggtaaaggt ggcagcaaca atgatgacag tgacaaggat gacaacagta 8160 gtgaggtgac acctgtctta gtccatttgt gttgctgcaa aggaataccc aaggctggat 8220 aatttataaa gaaaagaggt tcatgctggg caccgtggct cacgcctgta atcccagcac 8280 tttgggaggc tgaggcaggc ggatcacctg aggttgggag ttcaagacta gcctgattaa 8340 catggaaaaa ccccatctct actaaaaata caaaattagc cgggtgtggt ggcgcatgcc 8400 tgtaatccca gctactcggg aggctaagtc aggagaatcg cttgaaccca ggaggcggag 8460 gttgcagtga gccgagatcg caccattgca gtctagcctg ggcaaaaaga gtgaaagtgt 8520 gtctccaaaa aaaaaagttt catttggctc acagttctgc atgctggaca agaaacatgg 8580 cgccaggatg gtgagggcct caggctgctt ccactcaagg cggaaggtga aggggagcca 8640 cagagatcat gtggcgagag ggtggcagca agtgggaagc agggaaggtg ccaggctctt 8700 ttattttttc tgagacggag tctcgctctg tcacccagga tggagtgcag tggcatgatc 8760 tcggctcact gcaacttctg gctcccaggt tcaagcgatt ctcattcttc agcctcctga 8820 gtaactggga ttacaggcat gcaccatcat agccagctaa tttttgtact tttagtagag 8880 acggggtttt gccatgttgg ccaggctggt ctcaaactcc tgacctcaag tgatccagcc 8940 acctcagcct cccacagtgc taggattaca ggcgtgagcc accacgccca gccaccaggc 9000 ttctttttaa cagccagctc ttgcaggaac caatagggag cgaactcatc cattactgtg 9060 aggacggcac caagcaagct gttcatgaga gattgcccca tgacccagac acctcccatc 9120 aggcccagtg ttctgaatca aatttcaaca tgaggtttgg aagggacaaa tatccaaact 9180 atagcaataa gaatgatgag aacaatgatg atgatgaaga tgatggtgac aactctgtcc 9240 caggccctgt cctggaggct ggtggctcaa tgcctgtttg gcagaggagg acacagaacc 9300 tgggggaccg agccccagca cctcagactc gggaaatgac ctgcttgagg tggcacagct 9360 cctctagact cccaattctt tcttgtccct tcagccagtc ctgtgcctgc cgcctttgtg 9420 ctgtccttgg agggaggcag aagcaggatg acaatgaggg caagttcagg gacactgtgg 9480 gagatgagaa aacttgctgt gtgaaaactc tccacgtggg agttccacac accccacatc 9540 aaattgccat atgtggacgt gaccaccctc gatgctgcac ctgcctgacc ctcactgcat 9600 cctgccccca gtgtcacctg aatcctggct ggagctgctc ctggtccccc atcctctggt 9660 ttgcttcttc cctccttccc tccctgcctt ccttccttcc cctgtgtgtt ttgaggtagg 9720 ggtctttcaa attgcaagac agctgttcag agaaaacctg tcagttccag acacctcttc 9780 agggaggtgg tgctgcctgg cacggcataa tacagatcct ttgctcggcc agagcctggc 9840 cccaggaacg catctccacc aagctgtaga agctgctagc aggaaaacgc gatctgacgc 9900 acatgctgcc gcccgcatcc tgccctggga gaccatggtg gggaggccag gcattgcgca 9960 gactctcact gagctgccct gtctcttctg gatgttgcct ttctttcctt tttaagcctt 10020 tttcttgaag cagtttcaaa gttaaagaag agttgtgaga atatgaagag gccctgcaaa 10080 tatccttcgc cagaaatgaa catttaccta cacgcgtgtc ctcatctctc cctgcacgta 10140 ttcatgcgta tcactatgtt cctgctgaac aatttgagag ttaagttacg gaaatgatga 10200 ctcttgagcc cagacacgtc agtgtatatt ttctttcttt tttttttttt ttttttgagg 10260 gtctcactct cttgcccagg ctggagtgta gtggcacaat ctcagctcac taaaacctcc 10320 atctcccagg tagctggcat tacagatgcc cgccaccaag cccggataat tttttttttt 10380 tttttttttt ttgaaacaga gtctcgctct gtgccccacg ctggagtgca gtggcacgat 10440 ctcggctccc tgcaagctcc gcctcccggg ttcacgccat tcttctgcct cagcgtctct 10500 agtagctggg cccgccacca cgcctggcta attttttata tttttagtag agacggggtt 10560 tcaccgtgat agccaggatg gtctcgatct cctgacctcg tgatcctccc acctcagcct 10620 cccaaagtgc tgggattaca ggcgtgagcc accgcgcccg gccacacctg gataattttt 10680 tgtattttta gtagagagat ggggtttcac catgttggcc aggctggtct cgaactcctc 10740 acctcaggtg atctgccctc ctcagcctcc caaagtgcta ggattacaag gcgtgagcca 10800 ccatgcctgg ccatcagtgt atattttcta agagcaagga ccatttcttt ttcttttttt 10860 tttttttttt ttgagacaaa gtctcgttct tgtcgcccag cctatgggtg caatggcgtg 10920 atctcggctc cctacaacct ctgcctcctg ggttcaagcg attctcctgc ctcagcctcc 10980 cgagtagctg ggattacggg tgcctgccac cacgcctggc taatttttgt atttttagta 11040 gagacggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc aggcgatcca 11100 cccgcctcgg cctccctaag tgctgggatt acaggcatga gccactgcgc ccggccgagc 11160 aaggaccatt tcttacagaa cacagtacaa taatcagaat cagaaaactt aatattgacc 11220 ccagactgtc acctaaaata cagttgtttc tcttctgact gttttattac ttcttttctt 11280 tttttgagac agggtcttgc tctgtctccc aggtagtgca gtgacaccat cacgtctcac 11340 tgtagcctcc acttcaagga ggctcaagcg atcctcctac ctcagtctcc tgagtagctt 11400 gggttacagg catgcaccac catgactggt taaattttgt atttttttgt agagatgggg 11460 tttcgccatg ttgcccaggc tggtcattac ttttcaaaca aacacaccag tatgtcatgc 11520 tctcctatct cccagtctca acagtaaaca gcatcccgct gctctcatgg tgacgcctcc 11580 ctgtgcccca cagcattttg ttgttgttgt tttactgaag tattttacag caaattccag 11640 acatcattct ttctgtgaga acttctgtac agatcactgg ttttcaaacc ctgggttgag 11700 acatgtcaaa atccaccggg tgggctgtga tcaatgctga acaaagacag gataaaaggg 11760 aatagatgat aaaatccgag tactttgtgc agggccggtc tgcgcttggt tgggatgtcg 11820 agtctggctt accagcagcc acagtccagg gaggtttggg aagcctggcc agcagaggcc 11880 ctggggctct gtgcagcttt ccctctggct tattgtggtt gatcctgacg tcagggctgc 11940 aggacccctt ggcaaggctg gcggcaggag agccagcatg ggcacaattg atgagggatg 12000 gagatgaggt ctgctccgcc ctcccctgtt cctggaagct ctgtcccctg gggactccaa 12060 gacttcccag gtctgcctgg tcactaaaag cgtgggctct agagtccaaa gttctggctt 12120 caaatccctg ttctgtcact tgctacccag atgaccttag gcaagttaac taatttctct 12180 gtgcctgttt cctgtgagat ggggacagga acggtcccaa cttcatgggg ttatagtgag 12240 gattcactaa ccatgaatac acataaaggg ctctgaacag tgccgggccc atggtgagtg 12300 ccaggaaatg tgcctgtcgc tcccacaggc ctgggccctc cgtccctcag ccccagcccc 12360 actcctccgc tacccctcac tcctcccata gggaaggatt ctctctcctg catgtgagag 12420 tcctgcaggg agcttttaaa aatcccagtg ccgggcccgg cgcggtggct cacacctgaa 12480 atcccagcac tttgggaggc cgaggtgggt ggatcacttg aggtcaggag ttcgagacca 12540 gcctggccaa catgacaaaa tcccatttct actaaaaatg aaaaaaaaaa aattagctgg 12600 gtgtcatggt gcacgcctgt agtcccagct actcgggagg ctgaggcagg agaatcactt 12660 gaacctggga agtggaggtt gtggtgagcc aaggtcacgc cactgcactc cagcctgggc 12720 aacagagtga gactctgtct caaaaaaaaa aaaaaaatcc caatgccagc cacacaccag 12780 accaattgcc ccagaatctc tgggggtggg gctcaggcag caagcagcat tttgttttta 12840 agagacaggc tcttgctgtc acccaggctg gcgtgaagtg gcacgatcaa ggttcactgc 12900 agtctcaacc tcctgggctc aagtgatcct cccacctcag cctcctgagt agctgggact 12960 acaggcacag gccaccacac ttgactaatt ttttaaaaat gttttatagc cagggtgtcc 13020 aatcttttgg cttccctggg ccacactgga agaagaattg tcttggacca cgcataaaat 13080 acactaatga cagctgatga gctaaaaaaa aaaaaaaaaa aatcacaaaa aaaattcata 13140 atgttttaag aaaatttaca aatttgcgtt aggccacatt caaagccacc ctgggctgca 13200 ggcagctgga gggctgcggg ttgtacaagc ttgttctttg ttttttgttt ttgagatgga 13260 gtttcgctct tattgcccaa gctggagtgc agtggcatga tcttggttca ctgcaacctc 13320 catctcccag gttcaagaga ttctcatgcc caagactcat gagtagctgg gattacaggc 13380 acccaccacc acacccagct aattttttgt atttttagta gcgatggggt ttcaccatgt 13440 tggccaggct gctctcgaac tcctgacctc aggtgatctg cccacctcgg cctcccaaag 13500 tgctgggatt acagacgtga gccaccgcgc ccaggcgtaa gcttgtttta tagagacagg 13560 gtcttcttat gttgcccaag ttagtcttgt actcttggcc ccaagtgatc ctcatgcctc 13620 agcctcccca agtgctggga tgacaggtgc gagttaccta atccggaaga aaaggtattt 13680 tgtaaagctc ctgggtgatg tgcggaggct gcagtgccca gctcttcttg gctgtagtgt 13740 ggatgcaggt tctgagtggg cagggccagc tcagggcctg agactctgca tgcacagcta 13800 ccgggaagcc tgtgctgctg ttccatgggc cattctggga acagcaaggc cctggataaa 13860 aggcctagct ggaaacctcg acctcctttc cctccctctc tgtcaggagg gacagcagca 13920 gctgacattg ttcggacttc tcctctgtcc ccagcacaga tcacttcccc acactcagtt 13980 ctcgctgctg ctcaatgaga ctgttatgtg cctcacccct ttttacattt ttttttttct 14040 cgagatgaag tctcactctg tcgcccaggc tgcagtgcag tggcacgatc tcagctcact 14100 gcaacctcca cctacgggtt caagtgattc tcctgcctca gcctcctgag tagccggtat 14160 tacaagcacc caccaccatg cctggctcat ttttttattt ttagtagaga tggggtttca 14220 ccatgttggc caggctggtc ttgaactcct gatccacgca cctcggcctc ccaaagtgtc 14280 aggattatag gcgtgagcca ctgtgcccgg ccagctcatc ccattttaaa gatgaggaaa 14340 gtgaagtctt gagataaact atccgtgatc acatggctgg gagttgccaa gctgggacct 14400 ggcccagcta gtgcaatggg gaagctccag agaccactcg taagttggaa tggctgcctt 14460 tcatacgcag ctggcccaag cctgttccca tcagtatctc tcgctttccc tcccttccca 14520 aggccccggt ctatgtcttg gtggtatctc ccacccatgt cttactagct ccacctggac 14580 ttccagctcc ttctcctcca aacccttcct ggcctgccat cttcacattc acctccccga 14640 tttctggccc agagcaagca tctctgacct cagcaggcac aggaatccct ggggccttgt 14700 gcgcctgggt gggcctgagc tgctgccttg ctccccagcc tccgggttgc tgatgctacc 14760 aatccaccaa cagcctgcac atgagggcca ggcctggggt ctcctcacag gtactagcca 14820 cacacccctc tagaaagcag acttgctcct tggcgtcctc agaataagct cttaactcca 14880 aaccagcccc agaaacccca ggtcccaccc atcttcggct tctccccacc tgttcctgcc 14940 tgacctccca tcccctgggg ttcctcccac ggactgttgc tttatcttcc tctggatctc 15000 tgcacactac aggcccctgt ggggtggggc cccagcctag ggattaggac agtcctgggt 15060 tcgagtctca gctccacagt ccctagtaag ctggtagcct tgggcaggtg ccgccacctc 15120 tctgagccct gatttttgtg tctgtgaagt ggggacagta atagtacctt gcggggctgt 15180 tactgaggag tgagtgtcaa gagcatgcag gggccccgca ccactggctg ctgcttctat 15240 ttttcaattg cttagaactc gggatgcctc atgttgcagg aacatcatga gaacactggt 15300 tgggacaatt ctaatacccg tgggctgggg gggccacacg tcctctatag ctcaggctgt 15360 cagatctcca aagaacctgc attaggggaa aaaaaaaaag cattagaacg ggaggtacat 15420 ggccatgggg gcctctgggc cacccccgag ccctgctggc aggtcttcac atctctgcag 15480 ctgcggccgt cctgtggctc ttgaaaggaa aggcttggtg gtgtcggttc cccatcatca 15540 gttcactgca gcctccgcct cctgggttca agtgacctca cagagccagg gctgcagacg 15600 ccgccttggc ttcctgtata tttaactttg aggcacccgt aagttttttc caccgtcaca 15660 gactccatct ttgagcaaat ccagcccaga tgtagttgac aggtggcatg acctggaggc 15720 cggtggtttc tctccaccac aacctcctgt tttgcactca tcagggccaa gggtgggggc 15780 ccggctgcac gtggccaata caaacaagtc gcgccctccc ctctctcagc gctgtcctct 15840 ctccacaggc ctgcagaggt gccgacatgg ggcttaagat gtcctgcctg aaaggtaagg 15900 cctgaagctc tgcccccacc agctctcatg gcagaggggg tgctgggttg gggggcagga 15960 gagaggggag ttgaagccct ctgccctgca gagggagcag ggcaccatcc cttaaagcag 16020 tcctgtacac agcaggtgct ctaaaaatgc ttgtcctgac tctgagcacc cctccaggcc 16080 ttctatttca ctagcagtgg gtgactggga aggtggcagt gccttggggc ctcagtttcc 16140 ccctcagggt gcctaatccc aggctgtgga gagtgaggga ggaggaggcc tttgcgaagg 16200 agccaggcat atgctgggct gtttgctttc ccaaggacac acccggggcc tgttatcacc 16260 cagacaggag gtccagcgtc caggtggtag gagagaaggc cagcgggaga aagttctaga 16320 aggacacaaa accactgaag ggtgttgtgg gtgttagcaa aggcagccca gacttctgtc 16380 ctgtgtgtgg atggccctgg ggcacctcag accaatgttg caggaaacct cccatcccaa 16440 gtccattgct gcccctcttc tttaccttgg tgacagttgc tttgttctcc ccagccaaaa 16500 acctgggagt cacgtgggcg gcccctggtc tgacttgcgg ccccgctgcc tgagaccgcc 16560 tctggctcca ggtgtcccat ggccagtggt gtgagtgcca agcttctagc ctgccccggg 16620 gccacctacc tgaccccagc agccccttcc aggcagaggc cacctaccca cctggagagg 16680 tggttgggag ctgagccaag cctgggatca gcctgcatgg tgtgagttgt ggcctcacca 16740 atgcctctgt gagacctaga tcaagggcct cagtttcctt atcagtaaaa tggggatcat 16800 ggcggacccg tctcaggtca ccgggagcac gagagcaggg cctggaacac tctggcggtg 16860 gctgctctta attaattgta ctatttcctt cgtcaaattc accaggctct gtagcccatc 16920 ctttgggttt aggcaggctt agggctttta gatgcaagct acagaagcgg atactggtta 16980 acaaggaatt tactggaaag ccgaggggag cccacaggaa aagtgaagta aggaggcgtg 17040 aaaaggcccc tgctgggagc cgggatgaat ggaccaccct tcagattccc aggctgggag 17100 gaatccgctc caggagagca tccgattggc ccagtttagg tcttaggccc gcccctttgg 17160 cctggaggga ggtgcatctt gattgacagc tcctccaaca ccgcttgcgg agagattggt 17220 tcccctggtg aaaatcgggg tgtcgtttac taagcgggat gggatgccgg acagacacaa 17280 acagcccacg tcctctccag gacctggctt cctctgagac tccaggctga ccccacagag 17340 gagtggggag atgtttgttg aatgagtatc tgtgagtggc tgaggttaat tcagcagcag 17400 acagtggttg agagggtcaa gcctaacccc ttgaaacttg aggactttct tcccttagac 17460 atgagttccc cagtgcctgt cacaaagtag gcattgagga tacttttctt ctttaaaaaa 17520 taatatatat cacataaact taccgtttta accatgaagt gtacaaggtt agtggcatta 17580 agcacgttca cagtgttgtg caaccatcac cccacccgtc ttcagaatga aggtttcatc 17640 atctccaact gaaactctgt ccccgttaaa cactaactcc ccgttccctc cccagccctt 17700 ggcagccacc attctacttc ctgtctctaa gaatctgctc tagggacctc gtgtcagtgg 17760 aatcatccag catttgtcct tttgtgtctg gtctccgtca ctcagtgtgg tgttttctag 17820 gctcatccac attgaacatg catcactgct tcgttccttt tcacggctga ataatattcc 17880 accatgtgga cagactacat tttctttatc cacttctcca acgatggaca ctgggttgtt 17940 tccacctttt ggcgattgtg tcaggacatc tttgacggag aaaccaggcc cctggaggta 18000 tctctgggac cacttttctt ccagcccaag gccgggactt gatcaggaag gtagaccaag 18060 accctgcaga tcctgacagt gcctgggaaa tgccctccca cctccaccca ccctcggccc 18120 ctcacgagtg aaagcacagg cagccagatc agggctcgtg gggctgggag cttttaaaag 18180 gaccgtcttc ctgtcggccc cagagctgct aagtgtgcta agtgctggaa cagcgcctgt 18240 cccgagtgtg gcttgtccat ccatttttca tggctggctt tggtgctgcc ggcccctgcc 18300 cacccccact cgcccagcct gggtctctgg aggtgatgag gcccacacaa gcatgggggt 18360 gacttgggga atggggatta gggggccaga actctttttt tttttttttt ttttttttga 18420 gacagagtct cgctctgtca cccaggctgg agtgcagtgg tgcaatctcg actcactgca 18480 acccccgcct cccgggttca agcaattctc ctgcctcagc ctcctgagta gctgggatta 18540 caggcgtgtg ccaccacgcc cagctaattt ttgtattttt agtagagacg gggtttcacc 18600 atgttgtcca ggctggtctt gaactcctga cctcaagtga tcctcctgcc tcagcctccc 18660 aaagtgctgg gattacaggc gtgagccacc acacctggcc cagagagaat cattttaact 18720 ccatatttga agtagccagg aactctgtaa catggggtct tactgtccta gggctgccgt 18780 aagagatgac cccaaactag gtggcttaaa agaggaattt attctctcac agttctggag 18840 gccagaggtg tgacatccag gtgtgagcag ggcctcgttt cttctggaag ctctaaggag 18900 gctccttcct gccaagctcc tggtggcacc agccattctt tggtttgtgg gcttagctcc 18960 agcctctgcc ttgtggcaca tggctttcct cttctgtctt cccttctctt ttaaggacaa 19020 ctgtcatttg ctttagcacc caccctagtc caggataatg tcatcccaag atccttaact 19080 caattacatc tgcggggctg cacggtggcc catgcctgta gtcccaacac tttgggaaac 19140 tgaggcagga ggatctcttg agcccaggag ttcaagacca gtctgggcaa cattgcaaaa 19200 ccccatccct acaaaaaata caaaaattat cagggaatgg tggcatttca tgcctgcagt 19260 cccagccact tgggaggcgg aggtgggagg atcccttgag cccaggaagt caaggctgca 19320 gtgagctgtg atcacaccac tgcactccag cctgggtgac agagccagac cctgtctcaa 19380 aaaaaaaaaa aatgacatca caaagatcct gttttcaaca atgtcagatt cccactcaca 19440 ggctccggtt aggtgtatct tttggagcgg gcaccgttca gccctggata cgattactct 19500 cactccctgg ggcctcaaca ctacacgctg cccagggcac caggaggagg gacccgccag 19560 gacccaggcc ctctgcccct ctgctctagc cccgcagcct ggcccaggga ctcagaccca 19620 cccacctgtt tccaggtgac cctcctgtac catgccccca gctccaggcc tccctgggtt 19680 caaatcccag ctctgcccct taacgatttg gccttggagc agggccagct tcacaggcat 19740 gtgacctctg cagctgcaca gggccccatg ctcagtttaa tgctcttaat acatattgaa 19800 caatgggcct cacatgttcg ttttccactg agccccacaa attacacagt ggttcctgcc 19860 ttagggcaag tgaccttgtc tctctaggcc tcagcttcct ctggggtaaa ctgaggcatc 19920 ctgcatccag cccacaggtt ttattgagtg ctgggttctg gagaggactt gaagaatcat 19980 aaagacagga ctctgctcaa ggacatacta tctagagcca caccatccag tagaaataga 20040 ttttgacgtt tctagcagtc ccatgaataa ggtacaaaga aacgggtacg attactttta 20100 atatgtttta tttaattcag tatattccaa acatcatttt aatgagtggg gtccagttca 20160 ctggtctggg aggttcagtc agctgatctg ggggggttca gttgtctagg ggatttaggt 20220 ttgtggtttg ggggattttg ttgtctggtc ttggggggtt gtctcgtatg ggggagttgg 20280 ttagttggct gatctatggg gtttaagttg tctggtctgg gagttacttg gctgggctgg 20340 aggctttact tggctggtct tgggggcttg gttggctggt ctaagagggt ttacctgtct 20400 tgtatggggg ttaattggct aatctggggg ttcagttggc tggactgggg ttacttggct 20460 ggtcttgggg gtttagttgg ctggtctggg ggtttagttg tgtggtctgg gggttcagtt 20520 ggctgatgtg ggggttcagt ggctggtctg ggggttccct cggctgatgt gggggttcac 20580 ttgcctggtc tgggggattt agtttgctgc cctcctttcc cttcccctcc agtctgggaa 20640 tctctccctc tagaaccaaa gtaggctttc tgagccggga ggcaccttgg cactcatctt 20700 gcaaagcctt acattacaga tagggaagtt gaggaccaag gagaggaagt gaccagctac 20760 agtcacacca actagaaatg agacatgggc tcctctaggg aggcagctcc gagacccgtt 20820 cttattccct ttggaggcgt ggttacggga ggcatgggct gaacccactc agcagagtgt 20880 gagggtcaca gtgggtatga cgttcttccc tgcgggcttc atctcacccg ctctgaccag 20940 ccacagcccc agccctcgcc acctcctcct tcctcagctc ccccaggggc tctgaggctg 21000 tgtaactgcc caggaagaca caggcccctt ccctattggg ctggctttgt gtcgatggca 21060 cccgacttgg ctggctggga tgggatctgc ccactgctgg gctggcttcc atctctaccg 21120 tgcgtgactg tccggtggct gctgtgacaa atgaccacgc tggggggctt aaaacagcaa 21180 tttttattct ctcattgttc tgaaatcggc cctggcaggg ccgccctccc tcctcagcgc 21240 caaaggagga accttcctgc ctcttccagc ttctgatagc ttcaggcctc ctgggtccag 21300 tctctgcctc tgtcttcacg tggccttcct ctcttcatgt tgccctgcat tcaacctccc 21360 tctcctcctc ttgtaaggac accaggcatt ggatttagag cccctccgcc cccaaatcca 21420 ggatgagctc atcatgagat ccttaactaa ttacatcggc aaagacctca tttccaaata 21480 aggtcatatt ctgaggttct gggttgatgt gaatttgggg gacactattc agcccccatt 21540 aagtcagttc acctctgagc ttcccctgtg gggggcagga atgtgcttct cctgtctggc 21600 aacaaagact ctgcccaagg gtggtagata ttgagagggt ggcataggag gaacacagct 21660 gtgccaacac ccctttgttt ccgagtccaa aggaaagggg ctgcagagtc cctctgctca 21720 agggcctggc catggtgact gtgacccacg ggagtgtccc acaggccaaa gaaaatctcc 21780 ctcgtgcctc accctataag ggttggcacg tgctggcatc aacaggatct gggcatggca 21840 ccctcatcac tgctgaactc tacagacagg gaggctgagg cacaggggac ctctcactgg 21900 ctcaaggcca catggccagt taggaggggt tggctccaca gacggaaggg gaaaggggga 21960 gtcgtctcct tggttcctaa gtgcgccctc tccaggttcc agcagggcgg cacagccaag 22020 gaaatggcat ggtcctgctg catggttctc agtggggtcc gggaccttct gtataggcat 22080 cacttaggaa ccagtcagac catcagattc tcaggaccca ctggatcaac tgagtcagga 22140 actcagggtt ttcaacacat cctccggggg gattccagtg gctgtgtaac tttgaggacc 22200 actggcaaag tggctctggg gtcagagatc cgagttcata ttctgggtct gcctctgact 22260 gactgcaacg ttgtgcaagt cacttcccgt gcccaggcct cagtttctgt gtctgtaaaa 22320 tggagtggtg actgggaaga tctcctgggt caggtctcga gagttttctg agataggcac 22380 taaagatggc acccaaggag ccgttacacc ttcctgctat ggaggtggct gcaggtgtgc 22440 gggggcctct gcaggaagac ttaaactgca ggcatgggct ttcccactag agtggctggc 22500 tggggcgtta gggctacctg ggaggacccc tgtgatctgt gaggttctgt gggggcgggg 22560 tgggcgtcag ctccagcctg ggttaactcc agtgtcacca tggatacagg ctcctgggaa 22620 tgagactggt cccagcaact gtcctgggga aggtcccttg gggctgcctg gggcttggtg 22680 ggaaagatga aggctttgtc ctgggttggt agtttgtcat tgttttttta attagacttt 22740 attttttagg acagttttaa tttacagaaa aattgaaaag atagtacaga gagttcccac 22800 acaccccaca ccagattccg ctgttatgaa caacttacac tcacacggtc cactcgttac 22860 agcaaaccaa tcaatacaaa tccattgtta tttatttatt agtgttttat ttatttctgt 22920 gcttatttat ttatattttt gagacaggat ctcactctcc ctctgttgct caggctggag 22980 tgcagtggta ccatcacaag tcactgcagc cttgatctct ggggctcaag tggttctcct 23040 gcctcagcct cccaagcagc tggagtatag gtgtacaaca ccacgcccag ctaatttttt 23100 tttttttttt tttttttttg tagagaaggg gtctcgcttt gttgctcggg ctagtcttaa 23160 agtcttggct tcaagcctgg acctcccaag gtgctaggat ttcaggcatg agccaccgca 23220 cccggccaga tccattctta ttaactaata tccacacttt ttgttttttt gaaacagggc 23280 ctggctctgt tgcccaggct ggagtgcagc ggcacaacct cagctcactg caacctccac 23340 ctcctgggat caagcgattc tcccacctca gcctcccaag tagctaggac tacaggcaag 23400 aggcaccaca cccggcttat tttttttgca tttttagtag agatggaagt tttaccatgt 23460 tgcgcaggtt ggtcttgaac tcctgggctc aagctatcct cctgcctcaa cctgccaaag 23520 tgctgggatt acaggcgtga gccaccgcac ccggccagat ctgttattat taatgaatgt 23580 ccacgtgatt ccgatttccc ccatgtattt tttctgtcgc aggatcccac atgatattta 23640 gttgtcatac ctccttaggc tcttggctgt gacagtttct cagacactcc tcgtttttgt 23700 ggggacccca ggctgccagg catggctgtg actccctcgc tcggggggct cagcctgggg 23760 ttgattggtg gttggccgtt atgataccca tttttctgat ttgccttcag aggcttgcgt 23820 ctagcccctg gtcaacccaa aacccagaat ccctccatat ggccccgtga cagtgtgaat 23880 gcctggctct gctggcggac agctgcaggc cagaattgcg tgagagattg ttccctccac 23940 aaacgtttat tgcgtcccta ccgtgcactg ggcgctggcc caggtgccgg ggctacaggg 24000 atgaacaagg cagtgtggtc ctggccactg ggagtgtaca gaggtgagga gtgaccttaa 24060 tgctaactca gtgctggatg gaagctagca cctgcctacc cggggtggct aggggtggca 24120 tcacccagga agcaccccag cctaaagagc tggcctggca cagagcgggg aaggggtggc 24180 tgtttccggt agcagaaact catgggcacg ggctgggaag caagcagcag cctggcgtgc 24240 atggtggagg aactggaggg gccacaacgc cggagaggat ggtagcagcc aggtggagcc 24300 aggcagggaa tgtggagttt ccatccctgg ggacaggagc tctgtgaaat gggagggtga 24360 gaaaaacgtt cattccacta atacatttca gcagtgttca gaacaaactg gaaatttcat 24420 acatttgaag ggagatcaca tggtggaatc cagtccccgc tgaaccagga gttagaaaat 24480 agccaaggtc aagcacccca cttccctgag ctttcctgtc cctgtctgta aaatgggctc 24540 aggctcctgc ctgcggggat cctgggggag gtcctcaccc actgcctgcc attgccaccg 24600 ccatgttcca ggggtctttg tctactctgc tgacctccac acccaagctg cgaacaggag 24660 ccaacgcaca gtcgctgttc catggtgctg gttcccttcc agtgcgggac agagcccaga 24720 ggagagtgtg tcccgggcaa ctccacacaa acatgtactg agtacctgct gcatgccagg 24780 cagcacactc agccctcggg atgcagcagt gagcagcaca gagctcctgt ccatggggga 24840 gagacggaaa tgtggaatgg tgtgtgtgaa caaacacaca cccagcaggc tggatttcgt 24900 ggtgagtgct gtgaagggaa ttgagcaagg aggtgcagtc gaggggatga ggcaaggtga 24960 ggggttctct gtggtgccga cactggagtt agccatgtgg atgcagggaa cagtgttcca 25020 ggcagaagga acagcaaatg caaaggccct gagtcaggac caagcacact gagctggtga 25080 gcagcgagga ggcaggtatg gaggccgggc tgagctggag gagctgaggt ccctggggcc 25140 agcaggtgat agaagctgag gtgtggattg agaacttcag agtaatacag gccaggtgcg 25200 gtaatacagg ccagcacttc ggaaagccaa ggtgggcaga ttgcttgagg tcaggagttt 25260 gagaccagtc tgggcaacgt ggtgaaaccc catctctaca aagaatagaa acattagttg 25320 ggtgtggtag catgcgcctg tagtgccagc tactcaggag gctgaggtgt gaggattgct 25380 tgagcccagg agatggaagt tgcagtgagc caaaattgcc aaattttgcc aaattgccaa 25440 aaccactgca ctccagcctg gcaacagagc aagaccctgt ctcaaaaaag aagaaataca 25500 aagcactgga atcattctag cccaggagtc taaacctcca cccacatcag aatcttctgg 25560 aaggcttcca aatggatgca gccactgccc attccccaga ggttgggatg agattggtgt 25620 ggatgggtcc caggcactgg tgctctagga ggcctcctag gtgattcccc tgggtggtcc 25680 aggctgacag ccaatgtcct tgccttccag atggggctgc ggtggggact ggctgcccaa 25740 gttaacaagg agcaagtcag cctggctggg aacccaggtg tgcaggctca attccagggc 25800 tctttctgga accttctgaa cagatctctg cccaggaggc aggagctcct gagagacacc 25860 ccactccagc ctcccttcgg ctcagggcag tggggtggat catcaaagcc tgttttaaac 25920 gagggagcag atggcgtctg atctcgcccc gccccctgcc cagggcagag cgggcacccc 25980 tcctggctta cagcagggac ttagccggtc ccccccccat cagtcaccca tgcttaagct 26040 aaacctccgg cacctgatat cctccgaaag gagggaggcc agcaggtggg agacgaagcg 26100 ccatttccag ccgtgcctgg gaaggtcagc ctggctggtc tacaccccag cactctgtgt 26160 tagtattcgg gtgatagttc ccaaggatgt tctcctcctc acactcctgg atccgtgagg 26220 tcaggaacca cgctgtcttt ttgatccctg tagccctggc acctggccca agacttggca 26280 cacacagacc acgcaacaaa tgtttgcaga atgaatgtgc tctcagcctt aggcaccata 26340 tggagaccct cctcggactg accctcccgc cggccggggt ggctgccctg tcatccccat 26400 tatcctcgtc atccccatga ttcccatcat ccccgtcatc cccgtcattc ccatcatccc 26460 acagggagct cagcgctccc aaagctcaca cctcaccagg caggttcagc tctttccctc 26520 catctccttt catccgcaca gcaaggcttc cgtgctgtcc actgtcccca ctgtagatac 26580 agaagctgag gtgtcaggtg gtaaagctcc cacctgaggt cacccagcca gagtatggcc 26640 gagctggatc cctaggggcc tcaggaacac aacccaaccc agcaagtcca gagtccagac 26700 agagcctccc cctcgttccc tgcagtttcc ttagggcctg gcctgcacca cgtgctctag 26760 aagtatctgt gggatggaca aaggtgagga atgagcctcc agggagacag agggatgggg 26820 aggtgctggg actcacggtc ccaccggggg tctccctggc tttgtgttgc tcaagactcg 26880 gaagtcagag cgggccaggt gcagtggcac acacttgtaa tcccagcact ttgggaggcc 26940 aaggcaggag gattgcttga gaccagcctg ggcaatatta gtgagacccc atttctacaa 27000 aataaacgta gcccggtgcc actgcattcc agcctgggca acagagtgag accctgtctc 27060 tgaaaaaaaa gaaaaaaaaa atcgaaggaa gttagggcag tgttgaccaa ttaccagctg 27120 ctggacatgg ccgggcacgg gagcagacca gcctagttat cctgggccag ggcatcgcgg 27180 ctgccctccc aggggcctgg tttccagaga gcagatgtgt gtctgggcag gggcagcctg 27240 ctcttgtgcc ctgtttttgt cacccaacag cacacaccag ggatggctcc tgtcagcccc 27300 acagtactgc ccaccctttc ccacagctgc acagcacggc tacgtgcacg ccccaccacc 27360 ctcgaaccca aatccggcct gccttgccca agcaggactt cagtaaatat ccttctacca 27420 tccactcaga aggtggccta gggtggaaca ttctagatgg ttggagggtg tgtacccttc 27480 acattttgac agctttgcca gtgaaccccc tgaagtcaca ccagcagccc cttccactca 27540 ccccatggga gatgaccgtg gccatagcgt taacagcttt cccgtttttg ccaatctgtt 27600 gggtgaaaaa tggtacctca ggagaagttc atgcttcctc tgtttttaac aggaagcatt 27660 taactttttt ttttttttta gtacagatgg gatcttgcta tgttgcccag gctggcttca 27720 aatgcctggc tggcctcaag ttgtcctcct tcctcggcct cccaaagtgc tgggattaca 27780 ggcatgtgcc actgcacctg gccttttttt tttttttttt ttttgagatg gagtcttgct 27840 ctgttgccca ggctggagta cagtggtgcg atctcagctc actgcagcct ccacctcctg 27900 ggttcaagtg attctcctgc ctcagcctcc caagtagctg ggattacagg catgcaccac 27960 cacacctggc taattttttg tgtttttagt agaaacaggg tttcatcatg tttgccaggc 28020 tggtcttcaa ttcctgacct caggtgacct acttgcctca gcctcccaaa gtgctgggat 28080 ttcaggcatg agcctgaaat tagctgtgtg atcttgggca agtggctcaa cctcttttcg 28140 cctccgtgtc ttccaggatg agctgggcgg gataacacca ggggctgttt agatcatttc 28200 aggagccaag tcctgtgaag gcactggcac cgtggcgcct ggtgcacata ggcgttcata 28260 gaacgtgctg agggacctgt cactgcactt gtctcttctc aacactgggg ccagcagctc 28320 ctggggccct gggccggggc tttcccgtca gcagtgagcc cctctgtaag attcgctgag 28380 gttgcctggg caacataggc cgggtcccaa agcatgttgc tgctgtcgga gtccaggaaa 28440 gtcctggtcc ctgatcaggg agcgagcaga gcaaggcagt cctggggccc tgggcccact 28500 cagcgggagc caggactccc cggagagctc accttgcaga gtggctggac ctgagctggg 28560 agtgacagtg cttggtgccg cttccgctcc tgaatgttgc tcctacctgg agctgcaaat 28620 ccagcccagc cttcagtctg ctccgctctc tggctgcggc ctttcccagc ttcagctgcc 28680 cacagggccc atgttcccct gggatactcc cagttcgctc aagtagcaac gttcaccacc 28740 tttctctggt actaactgga atcggcctgc ttatactact ccttccaaag cagtaataat 28800 ggtgctaatt atatggcctg actaagtgcc tgccattcga caccttcctc ttagtaccat 28860 gcatccttat gacagcactg cagtatacag gttattatct agggcaaaag ttacagtcag 28920 agctgggcac agtggctcac acctagaatc ccagcttact tagggggccc aagcaggaag 28980 atcacctgag cgcaggagtt agcaggccaa ggcagcaaga ccgcgtgagc ccagaagttt 29040 gagttccacc tggcaacata gcaagaccac catttcttta aaaaaaaaaa aaaaaaaaaa 29100 aaaaaggtta gaatctctat tccaatgaga aggctaactg tgtgtagcaa ttgttagcgc 29160 tgataacccc ctttgcagta ggtgacagag agggtaagaa acttgttcag accacacagc 29220 aggtcaaggg cagactgggg gcttgggttc ctctggcttg ggccatcctg gagcccctcc 29280 gtgtagcccc aggcactggg accacatggg gacagaggaa gccagcagct ccatgccagg 29340 agtgccagcg ccagccctga aatgcccagt tattgttgca gtgaatgaca attacccctg 29400 tctttgaaga ccgtgggtga cgggcctgct cccccgacag ccccatgtag agctgccaga 29460 ttgaggagga aaataacata aaaacaggat gcccagttat atatgaattt cagataagga 29520 atactgtcaa gtagaagcat gtcccaagca ttgcatggga catgcctcta ctaaaaaaac 29580 tatttgttaa cctgagattc aaatgcgatg gaaggcccgc attttacctg gtgaccctgc 29640 cctccaggga cagttggcaa tgtctggaag tatttttggt catagaagct gggggtgcta 29700 cagggtctag aggccaggga cactgctaaa cattgcctga cacacaggac agccccaccg 29760 cagagaatga ccaaagtgtt agcagcgcca aggctagggg accctgggtc acacacgagt 29820 gtttccgtgg ccaggcaggg tgccaagtac gtggcttttt tttttgttct catggttgtc 29880 ctgctcttgt ttccatttta gggatgagta gattgaaggc tggaggaggg gacactgctg 29940 ggaagtgatg gagcaagggc tggacctggg cttcattttt ttcttttctt tggagacaga 30000 gttttgctct tattgcctag gctagggtgc agtggcgcga tcttggttca ctgcaacctc 30060 tgcctcctgg gttcaagtga ttctcgtgcc tcagcctccc aagtagctgg gattacaggt 30120 gcccaccacc acggctggct aattcttttt gtatttttag tagagatgag ttttcaccat 30180 gttggccagg ctggtatcga actcctgccc tcaagtgatc cacccgcctc ggcctcccaa 30240 agtgctggga ttacaagcat gagccgccac gcccagcgcc acccccaacc gctttttttt 30300 tttttttttt ttgaggcagg atctctcttg cccaggctgg ggtgccgtgg tgtgattgca 30360 gctcactgta accttaaact cctgggctca agcaatcctc ccttctcagc ctcccaggta 30420 gctgggacta caggtgcaca tcaccacatc tggctaattt aaaaaaaaat ttttttagag 30480 atggggtctt gctatgttgt ccaggcctgt cttgaacaga attgctgggc tcaagcaatc 30540 ctttgtcctt gtccttccaa agtgctggaa ttacaggcat gagtcactgt gcccgaccct 30600 ggacctggcc tttggaatct gggctcacca cactgtacct acaccctcca cagccttccc 30660 agagcgccca gtgctaggat gagcaggaac agaccacggg aactgggagg gctgcccagg 30720 agggaggaag tgcagtcagt gcccagggca ggaatgtggt ttggctgggc agagccaggc 30780 ggctgggcac cttcccccac cttggtgtgt cgaagctcct gtctctagct cctctcaggt 30840 tgtctctctc cagcagctca tccctgacgc aagctagggc tttttcctta attaaaaaga 30900 gatttaaaac atccactgct gtctctatcg ggcctgggat gcctcgaaaa ggtaaaaccg 30960 ccaagagcta ccccagcctc atccataata acacaaagct ttccctgtaa ttggaattaa 31020 aaaaaaaaaa aaagattaaa cgcatctgga acccttggag gaatttatca gtttgctttt 31080 gaaagacctg cactaaatcc agacacccgg tcatctctga gggattagtg tcaccccgct 31140 cagcccctgt ggcccctctg ttcctgcctc agggcctttg cgtgtgctgt ggcctgtggc 31200 ccctctgttc ctgcctcagg gcctttgtgt gtgctgtggc ctgtggcccc tatgttcctg 31260 cctcagggcc tttgtgtgtg ctgtggcctg tggcccctct gttcctgcct cagggccttt 31320 gtgtgtgctg tgggtgcctc gggaatctct cctgccgctt tctgattgac cccttctgaa 31380 aagccttttc caattcccag tctcccctaa accctgcttc ttggtactgt gagtgggctt 31440 atcatctgcc cctagtccct gcttgaactg acccaggatc ttggaaatat ctttgtgctt 31500 ccagccccca gatcacaggc tgtgcgcaaa caggctgtgc cctgacttct ctgtgcctca 31560 gtgtgcccgt ctggaagatg ggggctgcct cactgggagg atcaaacgat cagtgcccag 31620 aggcactcac acagtccagc ctcccacaag cactgttctc aaagctcagc atcgtgggcc 31680 cctcccagtg atagcttgaa tcactgggga ccctcctgct ttttctccag ttgaccctga 31740 aatcttgggg acctgattcc tgctactgga gcctggacag gaggtgtagg ggaaaggcac 31800 agataaacct ctgtagaggc cgttctttcc gcagcagtgt ctgcagcacc tggggccatg 31860 cagggcacac agcaggtgca caataaatgc ctgttgactg gccacctccc tggcccaggc 31920 tcagagctgg ggtgttacac ctgtgctgca aaggagggtg acataagctg gctctgcagg 31980 tgagaaagcc caggccgaga ggcagtgtca cagcaggaag cagaagtgag attcagatgg 32040 aggatgtcct ccttcccaag cccctggcca ttcccataga ataagggaaa attgtgcccc 32100 aagagtcagg ctggaaccag gaatattttg tgtagcaccc actccagctg cgtgaccgca 32160 agggggcgac aagtcccccg acccacactc ggggctggaa cagtagccgt tggcacccag 32220 taggtgctga atgttgaagg aatcaatgaa taagtgccct gaggacactt acacctgcag 32280 ttcaaatcac gtgatgtgga tctaagctta gcatcaactc gtgatctgaa tgacagcttg 32340 tgtttattac gtgtgcacag cgaggccagc actggagttt tctcatccac aaaacgcata 32400 tagaatcatc gcaccgcatt ggctggagtg aggactcaag tgtggtcctt aacctctcat 32460 gcctgcccac ccggacctgg gcactgttat ttaccccagt tctgcaggtg aggaagcaga 32520 ggcccaaaga gggggagcca ctgcccaggt ggaccgtagc ccaggtgggc cgtctggccg 32580 tccatcgcat cgtgggtccg acaggctgga gccctgtgtg tgtgtgatgg tgccttgggg 32640 aagagggcgt ggtcccattc agggcctcca agtgaaacgt ctggggtgca agcccaaacg 32700 ctgtttttaa aagaatcagg ccgtatgggg tggcttatac ctgtaacccc aggactttgg 32760 gaggccaagg caggaggatc gtttgagcct aggagttcaa gaccaatata atgaggccct 32820 gtctctacaa aaaagtttaa aacttagcca ggtgtggtgg agagtgcctg tagtttcacc 32880 cagcactttg ggaggccaag atgggagaat cgcttgagcc agggaagtcc aggctgcagt 32940 gaacctgagc cacagagaga gaccctgtct caaaaaatca attcattaat ttaaatgaaa 33000 tgaaaaagaa ctagtagagg gcgcacgtga gccgtgatgc ccacgcttgc tcctgtctcc 33060 agcgggtgtc tgcggtgacc tctgggcggc cgggagttca ccaagagctg gcacagggaa 33120 tggtgccctg accccaggga cctgggcatc ctccacagag cctggatgta gcgtctcggg 33180 cacgggcttg cctggctcag ggcttttgaa ggatcagggc tgcggatccc agcaatggtg 33240 agggcagtgg ggcctggagc cacgtcaagc cccagccctg ctccccaggc tctgtgtatt 33300 accagcacgt tacctccctt ctccaaagct cagtgttctc ctttgtagca tgggcgtgat 33360 cctagtgttc tccctgaggg atggtgtgag ggttgaatgc aggagtgcaa atggcaggct 33420 cagcccagag cctggctccg gatgctttgg aagtagtggt ctcagcggag aggcggcacg 33480 gcacccccag ctcaggaccc cctaggcccc ggccagctgg ctccccgagg gtcatttctc 33540 cccacacttg gcagccccac accccacacc tggcacttcc tgcaaggctg gtgtcataac 33600 agttttacag ccagggaaac tgaggctgca agagtaaagc cacctgttcc cacagtggcc 33660 ctagctcagg ggttcccatc cctggctgtt aaagtcacct gggagttttt caaaatcctg 33720 gcacttctca cagagccttg aatcagcctg ggctgaggcc ctggataggt gatgttaact 33780 tcccaggtga tctcaatggg cagccgcgat gggaaccgct gtcctggagc taggagggcc 33840 cagagccggg tctcaaagcc tgtccaacct cgccatgcca gcacccgcct atgtaaccca 33900 tgtggaaatc cagctccagg ggcctgggtt ctgtggtctg gtctgcgtgg ctctgccccc 33960 actgcgagga cagtgcatgg ccgcagagcg ggggtcaggg cctggtgacc cggagcacga 34020 agcctccccg gaagtgggga ggtcttcctg cacaggctcc atccttctga agccttggga 34080 cgggcctggg tccctgggat ctgctccctt ccttctggaa tcccaggctc aggaaatagg 34140 cttttaatag cccgaggcag gcacataatt aacaaataac aattctggcc ttagcacaaa 34200 tgagctcctt gtctggggca gggctggcat ttggttttta atccccagca ttggcttcat 34260 cctcctgaga gctttccctc ctgtttggcc acctctgctg ctgaggcttg gcaggccctg 34320 gggatgtgag aggggctggg gtgtctctct cctccctgcc tgccctcccc tctccctccc 34380 ttcctcctcc ctctcgcctt cctcctcctt cccttcctcc tccttctccc tctgccttgt 34440 ctgctccctc ctcctcctct cttcctcttc ctgccctgtc tttcctcctc cctccttttc 34500 tccctccttc cctctcccct tccctccctc tgtcctcctt ccctccctcc tcttccttct 34560 cccctgtctc ctccctccct tcctcctctc cttcgtcccc tctctcctcc tcccttcctc 34620 tccctcctct cttccttccc ttcctcctct tcctcctctc tccctcttct ccctcctccc 34680 ttcctcttct ccctcctctc ctctctcctc cttccctccc ttcctcctct tcctcctccc 34740 tccctcttct cccccaactt actcctccct ccctcttctc cctccttccc tctcctcctt 34800 ccctccgttc tctcctcctt tcctcctctc cctccaaccc cctctcctcc gagacttctg 34860 cctctccagg gctcactgag aacctgatcc ttccaggtta tatgtgtagg ttttgtcctc 34920 aagctccaga ccacgttaaa atgcaaacgt ggggtgtttt attttagaat cttggagtat 34980 tcaccgagga aggggtttgg agactgagca gggaagctcc ctcctgttac agacacgatc 35040 atcagcgatt ccttttgtcg ggggcctccg atcatcagcg attccttttg tcgggggcct 35100 ccgcaaggag ctctttgtgg atgataatag agaacactta tggggcagct ggctgggcga 35160 agtgctttcg tgaattcatt catgtcctca cacgcagccc ttcaagaggg agctgccctg 35220 cccacctgca gctggggttc tggctgtggc ttttgttttt ggcacgaaca agcctcaggc 35280 tttcgaggtt ctgctattgc cagtgtgtcc tagatctcag ctcccctccg cagccagtcc 35340 tggatgttat agagcaggga ttggcaacca cagccctgag acccaatcct gcctgatgcc 35400 tgcttttaga aagaaagttt tattgagaca gagtcatgct cgttcatttc cacgttgtct 35460 acggctgctt tcaggctgcc gtggcaaagc tgtgtgtgta gtttgtgtgg cccacagaga 35520 tcaaatattt cctgcctggc cccttgcaga aagtttgcca gctgttacat gggattatgc 35580 tacaggaagc accggctctt ggggtcagcc agattccagt ctggggatgg atcctggccc 35640 tgcctcccac tagctgttca gttgtgggtg gatattactc tcttaggtcc ccagtttcca 35700 catttgtaag atggggctgg tgacaccgag cacggtggcc atggagcctg aaggagcgca 35760 cgcctcggcc ccagtagatt gtctgggcgg tggcaacaca tccctttgtc tgtggttgtt 35820 tggggtaggg gcgcctctct ccaagtgact tcctttgatt tgtttcacac tctgggcttc 35880 tgtgcaagat tgcaggagaa atgttctctt cttttttttt tttttttgag acggagtctg 35940 gctctgtcac ccgggctgga gtgcagtggc gtgatctcgg ctcactgcaa gctccgcctc 36000 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 36060 caccgtgcct gcctaatttt tttgtatttt tagtagagac ggggtttcat tgtgttagcc 36120 aggatggtct cgatctcctg acctcatgat ccgcccgcct cggcctccca aagtgctggg 36180 attacaggcg tgagccaccg cacccggctg aaatgttctc ttctttaaag aaggttcaaa 36240 ccccactgta ttagacctgc ttcgatggga ctgtgtgggt gccgctgagg ggctcggagt 36300 tctgttgggc tgaggtggcc tcttccctca aaactaccca gcagtcgggg gccaagagtc 36360 ttccaaggcc gggcacggtg gctcatgcct gtaatcccag gactttggga ggccaaggcg 36420 ggtggatcac aaggtcagga gttcgagacc agcctggcca atatggtgaa acgccgtctc 36480 tacgaaaaat ataaaaatta gctgggtgtg gtggcaggcg cctgtaatcc cagctactag 36540 ggaggctgag gcagaagaat cgcttgaacc caggaggcag aggttgcagt gagtcgagat 36600 cacgctactg cattccagcc tgggcgacag agcaagactc cgtctcaaaa ataaataaat 36660 aaataaataa ataaataaat aataaataaa taaataaata aataataggt cttccaaagg 36720 aggaaacagt gttggggttc agaaggtggg gaggtgactg gggcagtgcc tggggtgagg 36780 ggcggatgct cgtcactggg tttgagaatg aggggaggga agtgagtggc tgtgcacagg 36840 acaaaggggg ctcatcatgg tcacctcaca ccagccgtgt gtcccaggga ccgtggccgt 36900 ctctccccag cccagggagt cggctgattc ccccactacc accttgcgct tgtctgtgaa 36960 aacaagaagg ctgcaaagag ttagactaac agaagtgggg cgggggcaca catgaccacc 37020 cacccttcca ccaccagctg caggtttggg gcttccccaa accaccctca tgtttgttca 37080 tttgctgaaa ggactcacag aagtcactgg aggctctgat tcccggttat ggctcattcc 37140 agggaaggga cccaggttaa gaccaaaggg aagacgctca cagggcagat cccacgaggg 37200 tcccaggcac agtctcccac tgtcctctcc tcgtggagcc atggacagca ccaactcctc 37260 ctgacgatgg tgcgtgacag cacagagcat catcaggagg gaagcccctt ggcttcagtg 37320 tccaggggct ttaaggattg aaccgtgtct tccaaaaatt cataagtcaa cctcctcgcc 37380 cccagggcct cagaatgtga ccttcttggg agtagtgtct ttgcaggtgt aatgagttaa 37440 gatgaggtca ttttagtagt gtgagctcct agtccaatat gacgggtgtc cttatcaaaa 37500 ggggaaatct gggctgggcg ctgtggctca tgcctctgat cccagcactt tgggaggcca 37560 aggtgggcag atcacctgag gtcaggagtt tgagaccagc ctggccaaca tggtgagacc 37620 ctgtctctac taaaaataca aaaattagct gggcatggtg gcgcatgcct gtaatcccaa 37680 ctacttggga ggctgagaca ggagattttg tttgaacccg agaggcagag gttgcagtga 37740 gctgagattg tgccactgca ctgcagcctg ggtgacagag tgagatccgt ctcaaaaaaa 37800 aagcaggggg gagtctggac agagacaaga cgcagggaga atacaatgtg aaggcaagag 37860 gtagagatgg ggtgaggctt ctacgagcct aggaacgcca gattgtcagc aaccaccaga 37920 agccagggga ggggcttgga acagtctccc ttgcagcctc cagaggaacc agccttgcca 37980 acacctggat ctggaacttc tggcctccag atctataaga caatgaatgt ccattgttcc 38040 agccgcctgg ttgacggtgc tttgttgtgg caaccccagg agacgaaggc actggggctc 38100 ctctggaggc tgattgattg ctcactttgg agctcaggct gcaggctgct gtctctccgg 38160 gcatgacccg gagcccccct ccatcaatca cgcctttgga cacccagtgt aaccacagcc 38220 cccggcaaac aaagactctc ctatcaggca agatattcca agggcttaga gagcacctct 38280 cagaaaccgc ggacagagac cagacctctt tttaggcaag attaaattat ttactgcaca 38340 aagggcccag agaggaggtg cagtgcacgc agggtcacac agctggtggc ctgattccaa 38400 agccagtgtg cctactgctt tcagtttttc tgagcctgca gccttggtca agctgcaggt 38460 gaaccaagaa tttggcctga atggcatggc tccaggtcct ctaggtgtac atgcttttgt 38520 ggattcaaac agatcatccc tgacagccca ggtgtaacct gcctctcaga ggaacacccc 38580 ttgggtgaac aaaggttacc ctgagaagcc tcctgtgatt tccccacagc cgggtatgag 38640 attcccactg tgcacctgcc atcccttcct actgggtcag ggaaagattt gctgactgtc 38700 agtaatctat cactgcataa caaactatgc caaaactttg tggcttaaac atcaaacctt 38760 tattatctca gagtttctgt gggtcaggaa ttgaggagtg gcttatctgg gtggttctgg 38820 ctcagggtcg atcatgatgt tacatccaag atgtcagccg gggctgcagt ctcatctgat 38880 ggctggactg gggctggagg ctccactgct gaggaggctc ccttgtggct gttggctaga 38940 ggccttgatt cctcacccac gtgagctgct ccacaggctg cttgagcatc ctcgtaacat 39000 ggtggctggc ttccccaaga gcaagtgttc caagagagag caaggaggaa gttgcaatgt 39060 cttttatgac ctcaccgtgg aagtcacaca ccatcatggc agtcctattt gttggaagca 39120 agtcactaag tccatccaca ctcaagggct tagactctgc ctctcagagc catatttcag 39180 aacccccaca ctgaccctac agtggtcact taggaacatt gtcctaatgg tggtcaaggg 39240 aggcctgaga acagtaggaa aaatattccc ccaacccctt attactcagc ttctcctgtt 39300 ggtcaggggc tctgatactt gagctaattt aatcccagcc tggcaccgtt tggggcaaaa 39360 ccaaagtgat gggacataga gacaaggatt gtaacaccta gcttaatgct gcctgaaggg 39420 tttttggttg cgtttaattt tttttttttt tttttttttt gagacagagt ttcactcttg 39480 ttgcccaggc tggagtgcaa tggcacaatc ttggctcact gcaacctccg cctcccggat 39540 tcaagcaatt ctcctgcctc agcctcccga gtagctggga ttacaggcgc ataccaccat 39600 gcccagctaa tttttttttt tttgtatttt cagtggagac ggggtttctc cgtgttggtc 39660 aggctggtct ccaactcctg accttaggtg atctgcccac ttcagccttc caaagtgctg 39720 ggattacagg tatgagccac cacgcccagc cttttttttt ttttttttaa gatggagtct 39780 tactctgtca tttaggctga agtgcaatgg tgtgatctca gcctacttca acctctgcct 39840 cccgggttta agtgattctc ctcctgcttc agctcctgag tagctgggat tacaggtgtg 39900 tgccaccaca ccgggctaat tttcgtattt tagtagagat gggggtttca ccatgttggc 39960 caggctggtc ttgaactcct gacctcaagt gatctgcccg ccttggcctc cgaaagtgct 40020 ggcattacag gcatgagcca ccgcgcccgg ctggcatttg aaatttaaag cactcctact 40080 tactctgtct cgagcatgcg ctaggctcaa gggaaacaca gatgaatgaa atagagactg 40140 tcctccaggt gttcacagca aagagaggca gaagtaaaaa taaatcatgt cattcattga 40200 tgaatgagtg agtgcagatg ggcaaaagag ggagcagcca gatctgctgg gacacctttc 40260 ccaaggaaga gcccgttgca ctgggctttg aaggataagc aggagcttgt tactcaggca 40320 gaggaagaaa gagcatccca ggcgggggga gcagcatatg caaaggcacg aaggggcccc 40380 aggagcctag ggagtctggg gaagtgtgag cactttggag agtggaggct ggagcgctgt 40440 ggagagtggg ggctggtggc cgggaatgag gctgcagctg gctgggccac atggtaaagg 40500 ctgacaactg gacccagagg ccaactagcc tatgatcagc atttcccaaa atctgtttcc 40560 cgactcatgg ttctgtgaga tgtgacaagg gctccttttt cattcctgag acgccggttt 40620 tcatctgtga tgcggggaca gctgcgctcc ttgctgcgag gcgtcaggac ccaggtgata 40680 gtgaagggag ggtggcgccc gcggttcccg gcggccactg atgcctgtct ctctgtcgtg 40740 tgtacgtgcg tgtgtgctcc acgcctggct tctcaggctt tcaaatgtgt gtcagcagca 40800 gcagcagcag ccacgacgag gcccccgtcc tgaacgacaa gcacctggac gtgcccgaca 40860 tcatcatcac gccccccacc cccacgggca tgatgctgcc gagggacttg gggagcacag 40920 gtgaggccgt cccctccacc gccaagccgg gtcggctgtg ggggcccggt ggagacagct 40980 ctcaggggcg tccttcctgg ccacggggcc tagcttgcgt ccccacctcc cactgggttc 41040 gttaaacatt tatggtcaga cctgtgtaca ctgcaccgtg agccccctgc cacggcgcca 41100 gcctcagcac gacgcggcgt gttaagtaat tagtagacag cccctgccag cagccaggac 41160 gcttgatgga tggggccggg ctggcccgcc acgccgcggc tccggccagc caaggtaatt 41220 gatggatgct ccttcccctg ccagcgggag gaccgctgct ccatcttgtt ggccgctgca 41280 gtttggccgg acaggacaga cttggaaaca cagctcgtgc ccaggctggg gccggaccct 41340 gggccttcca gatgcagctc actgctggga gcggcgagga aatagagttc ttcccaggga 41400 gagggtgagg aggtgggaga cagaggccca aatcggcagc cctacctgcc tctctgtgat 41460 acctctggag ctggtgggac aaattgttca tgtattcatt gagcagagat ttactgagct 41520 gggcctatgc cgggtgctga ggctgctgct atgaataata ataataataa taataataat 41580 aataataaca ttggggatgg tcatgatagg tagcactgta ctgagcgtaa caaatggatt 41640 ttcttattta gttcttacag gaattctcag agttcagagt taagtacaga tttcatcccc 41700 attttattat ttgtatttat ttattttttt gagatggagt gttgctttgt cacccaggct 41760 ggagtgctgt ggtgcactct cagctcactg caacctccac ctccttcatt caagtgattg 41820 ttctgcctca gcctcctgag tagctgggat tacaggcacc tgccaccacg cccagctaat 41880 ttttgtattt tagtagaaat ggggtttcgt tgtgttggcc aggctggtct caaactcctg 41940 acctcaggtg atctgcccac ctgggcctcc caaagtgctg ggattacagg catgagccac 42000 cacaccccca ttttagacag gggtaaacta aggttgagag aggctgagac acttgccatg 42060 tgctagtcac gggtgccgca ggcatgcagc cccaggctgt gtgatctgca cttcaccccg 42120 tggcccccag gccggatgtc ctccccgcaa gtggcatcag ttagctgaca gccatcatga 42180 catgggtctc gctgggccca tgcaggggac aaggcaccca tgaggctggt gtagtgtgca 42240 tggaaggctg tctgggaggg ggaatccata gacccttcca gatgtcctga gcttgggtct 42300 ccacttgccc agcagagcga gtgactggga gaaagctgtc aggcccctct gggttgggcc 42360 agtgcaggtg ctgggtggag ccatggtggg tgcaatgggg cgcattcctc tgtgaccttt 42420 ccaagtgcct ggcaccaggc taaatgcttt tcacaaatct catttaattc tcattccaac 42480 ccttatctct agtttagaaa tggggaaaca aacaggtcca gagagggaca gtgcctcgcc 42540 cagggacaca cagcaaggtg ggagaagagc tgggctcctg ctgcagtgcg cctcctgcac 42600 cccagtactg tctaatcaga gagcccagtg tgggcggaca gaggcgcagg tccttagctc 42660 ggctgtcaaa gtctcttccc tctctgagcc tgtgtcctca cctataaaat gggatcatac 42720 caccttccct gctcccagga ccagtggggg cataggggag acacagggtt actctacaaa 42780 gtccgagccc cagggaggtt cctgaacgct gggaggggtt cctcttaaac tgaagcagtt 42840 ccggggtccg attcacccag aaggatccag catcactggg ctgggtccca tctcagcctc 42900 tggcagcacc agaaagcaag gaatcccaga ggccccagcc ctgcagttcc cagggaaacg 42960 gggcttggtg tggtgggggc agggtgcatc caggtgtcca tcccctcttt ctcctagtct 43020 ggctggatga gacagggtcg tgcccagatg atggagaaat cgacccagaa gcctgaggag 43080 gtgtcctggg tttggctggc tggctcctgc tccagcggcc cggcttcagg tgtccggggg 43140 cgtggctgcc tggagcaggt gtgctgaata ccctggatgg gaactgagcg aacccgggcc 43200 tccgctcaga gagacgtggc aggaccagcg aggaatccag cctgtccact tccagaacag 43260 tgtttcccag gccccgctga gtggaccgga cctctgacac ctccaggttc ttgctgactc 43320 cggcctggtg aaagggagcg ccatggtcct ggctgttggg gtcccaggga gaggctctct 43380 tctggacaaa cacaccctcc cagcccccag ggctgtgcaa acacatgccc ctgccataag 43440 caccaacaag aacttcttgc aggtggagtg gctgtttttt ataagttgtt ttacagatac 43500 ggaaacagtc caaaatggga tttataattt cttttttgca ttataaataa agatcctctg 43560 taacaa 43566 <210> 6 <211> 4937 <212> DNA <213> Homo sapiens <400> 6 ctccgcactg ctcactcccg cgcagtgagg ttggcacagc caccgctctg tggctcgctt 60 ggttccctta gtcccgagcg ctcgcccact gcagattcct ttcccgtgca gacatggcct 120 ctggcaccac caccaccgcc gtgaagattg gaataattgg tggaacaggc ctggatgatc 180 cagaaatttt agaaggaaga actgaaaaat atgtggatac tccatttggc aagccatctg 240 atgccttaat tttggggaag ataaaaaatg ttgattgcgt cctccttgca aggcatggaa 300 ggcagcacac catcatgcct tcaaaggtca actaccaggc gaacatctgg gctttgaagg 360 aagagggctg tacacatgtc atagtgacca cagcttgtgg ctccttgagg gaggagattc 420 agcccggcga tattgtcatt attgatcagt tcattgacag gaccactatg agacctcagt 480 ccttctatga tggaagtcat tcttgtgcca gaggagtgtg ccatattcca atggctgagc 540 cgttttgccc caaaacgaga gaggttctta tagagactgc taagaagcta ggactccggt 600 gccactcaaa ggggacaatg gtcacaatcg agggacctcg ttttagctcc cgggcagaaa 660 gcttcatgtt ccgcacctgg ggggcggatg ttatcaacat gaccacagtt ccagaggtgg 720 ttcttgctaa ggaggctgga atttgttacg caagtatcgc catggcgaca gattatgact 780 gctggaagga gcacgaggaa gcagtttcgg tggaccgggt cttaaagacc ctgaaagaaa 840 acgctaataa agccaaaagc ttactgctca ctaccatacc tcagataggg tccacagaat 900 ggtcagaaac cctccataac ctgaagaata tggcccagtt ttctgtttta ttaccaagac 960 attaaagtag catggctgcc caggagaaaa gaagacattc taattccagt cattttggga 1020 attcctgctt aacttgaaaa aaatatggga aagacatgca gctttcatgc ccttgcctat 1080 caaagagtat gttgtaagaa agacaagaca ttgtgtgtat tagagactcc tgaatgattt 1140 agacaacttc aaaatacaga agaaaagcaa atgactagta aacatgtggg aaaaaatatt 1200 acattttaag ggggaaaaaa aaacccacca ttctcttctc cccctattaa atttgcaaca 1260 ataaagggtg gagggtaatc tctactttcc tatactgcca aagaatgtga ggaagaaatg 1320 ggactctttg gttatttatt gatgcgactg taaattggta cagtatttct ggagggcaat 1380 ttggtaaaat gcatcaaaag acttaaaaat acggacgtac tttgtgctgg gaactctaca 1440 tctagcaatt tctctttaaa accatatcag agatgcatac aaagaattat atataaagaa 1500 gggtgtttaa taatgatagt tataataata aataattgaa acaatctgaa tcccttgcaa 1560 ttggaggtaa attatgtctt agttataatt agattgtgaa tcagccaact gaaaatcctt 1620 tttgcatatt tcaatgtcct aaaaagacac ggttgctcta tatatgaagt gaaaaaagga 1680 tatggtagca ttttatagta ctagttttgc tttaaaatgc tatgtaaata tacaaaaaaa 1740 ctagaaagaa atatatataa ccttgttatt gtatttgggg gagggatact gggataattt 1800 ttattttctt tgaatctttc tgtgtcttca catttttcta cagtgaattt aatcaaatag 1860 taaagttgtt gtaaaaataa aagtggattt agaaagatcc agttcttgaa aacactgttt 1920 ctggtaatga agcagaattt aagttggtaa tattaaggtg aatgtcattt aagggagtta 1980 catctttatt ctgctaaaga agaggatcat tgatttctgt acagtcagaa cagtacttgg 2040 gtttgcaaca gctttctgag aaaagctagg tgtttaatag tttaactgaa agtttaacta 2100 tttaaaagac taaatgcaca ttttatggta tctgatattt taaaaagtaa tgtttgattc 2160 tcctttttat gagttaaatt attttatacg agttggtaat ttttgctttt taataaagtg 2220 gaagcttgct tttttaactc tttttttatt gttattttat agaaatgctt tttgttggcc 2280 gggcacagtt gctcatccat gtaatcccag cactgtggga ggccgagacg ggtggatcac 2340 aaggtcagga gatcgagacc atcctggcta atgcgttgaa actccgtctc tactaaaaat 2400 acaaaaaatt agctgggcgt ggtggtgggc acctgtagtc ccagctactc aggaggctga 2460 ggcaggagaa tggtgtgaac ctgggaggtg gagcttgcag tgagcagagc ttgcagtgag 2520 acgagcttgt gccactgcac tccagcctgg gcaacagagt aagactcagt ctcaaaaaaa 2580 aaaaaaagag tgaaatgctt tttgtttgct tcagtttttt atcatgggga gatctttttc 2640 ctcagaattg ttttcttttc actgtaggct attacaggat acttcaggat caagatacag 2700 aaccttttat ttaaagagtt tgtaaagtca atgtgtttgt ttgtgtctct gagattgact 2760 tcaagataat aagctgctaa ttgtaaacaa aacagttacc ctccagtatt aatatgactc 2820 attagtgtga gccatttggg tcaagtatga ttatgaccct tggacttcct gatgtagtat 2880 taaatttcaa ctctggttat ccattagcaa tctgtagaga acttaatgaa cctgaaccca 2940 ggcttctcta gctctggtaa cgtgtgattg ttttcactac aatatgatac atagatggta 3000 ccttactttt cctcattctt aataggtgtc taagaatgtc agggcaaaag tatgggcatt 3060 tttcttgcta tgttcagaaa gtacagttct ctccaacttg cagaggtact tttcttgatt 3120 aaatagcctt ctctagcaac atcattttca gactaactaa atgaatgcag tatactcttt 3180 tctttgttct caatcattca ctccttatgc aaagccaata taattttcct cataccttat 3240 gcttgaggat attgttgaag aacacttcct ggaacacttc tcacttgtga tgctgtacta 3300 attttttttt tttaatttaa gctagtatac taagtgaaca ccatggtcag ttgtgagcat 3360 tttggtttcc gcaaaggatg gatggtgagc atcatgggaa agctgtagtt tagtgactta 3420 gcccttagtg attaatagat ttgcatgtac atagaagtct ttgttggcct tataatctgc 3480 tgttatattt ggcatggatt ttcatggttt tgagaatgac atcctggccc tgtggtcccc 3540 gagggtcatg gtccttgtga cctggcccct gttcactgcc cccttcgcta gcacgagttg 3600 ctgtgcaggg ctggaggtag ctaccatggc ttgtttcaag gaaggaaact ctggtacggt 3660 ggcaccctca ggagtggagg acagtgaact tccttgaaga gggagtgact aaggtgacct 3720 ccaacctgcc ctgagccagc tgccctgcag gtgccacgtg agcctgctct ggcatccaca 3780 ggatgctcct ggagcctctt ctctggctgc tacctcaggg catggttgtg gccccaccaa 3840 cacctatttt ccaaataatt attcattctt gtgacagtgg cctgaacatg tttttaattt 3900 tctcaacaag catttagcca gcacttatcc agtgaaacaa tttgataagg tttcaaggag 3960 tatctgatgg gttaggaagt cacgaaatga ggagttcttg ccacatttgc agagtccctc 4020 cttgataagg tttggcggtg tccccaccca aatctcatgt tgaattgtag ttcccataat 4080 ccccacatgt tgtgggaggg acccagtggg aggtaattaa atcatggggg tggttacccc 4140 cacactgctg ttctcatgat actgagttct cacaagtcct gtttgtttta taaggggctt 4200 ttcccccttt tgctcaacac ttcttcctgc catcatgtga agaaggacgt gtttgtttcc 4260 ccttctgcca cgattgtaag tttcctgagg ccttcccagc tatgtggaac tgtgagttaa 4320 ttaaacctct ttcctttata aattacccag tcatgggcag tcctttacag cagcatgaga 4380 atggactaat acactcctca aatgttttga agattgttgc accttggaac taccagtgtg 4440 cacacaatct ggctcaatgt atatattggc ccagcaaggc aaagaactga agttccagga 4500 tggaagaacc tgtgttctcc tcataatagt atagaataat tcaagatagg caagaaggac 4560 agcagtaaat gaagaccatg gaagaaaaga aggaatgcca aagatcgagg aaatctacca 4620 agactagtag ggtagtccag aagaagctgt ttcagggcct gttgccagct atgcctttga 4680 gaacctcggg atcccaaaga atgaggggaa tttcttcaga aagacaatct cggcatgcat 4740 tatttctttg ttttgaagat tcactcatgt tgcatgcatc tgtagcttgt gcctttttta 4800 ttgcctagta gtattctgtc atatgcctat cttacaattt gattatctat tcacctgttg 4860 atgaatgttt gaattttttc catttgagga attttatgaa taaagctgct ataagcatga 4920 aaaaaaaaaa aaaaaaa 4937 <210> 7 <211> 2436 <212> DNA <213> Homo sapiens <400> 7 tccgactcat cccggccccg ggatggcgtc cccacgggaa ttgacacaga accccctgaa 60 gaagatctgg atgccataca gcaatgggcg gcccgctctg cacgcttgcc agcgcggtgt 120 gtgcatgacc aactgcccaa ctctcattgt catggtgggc ctgcccgcca ggggcaagac 180 ctacatctcc aagaagctga ctcgatacct gaactggatt ggtgtgccca ctcgggagtt 240 caatgttggc cagtatcgcc gggacgtggt caagacctac aaatcttttg aattttttct 300 ccccgacaat gaagagggcc tgaaaatcag gaagcagtgt gccctggcag ccctccgtga 360 cgtccggcgg ttccttagtg aggagggggg acatgtggcg gtttttgatg ccacaaacac 420 cacccgagaa cggagagcga ccatctttaa ttttggagaa cagaatggct acaagacctt 480 ttttgtcgag tccatctgtg tggatcctga ggtcatagct gccaacatcg tgcaagtgaa 540 actgggcagc cctgactatg tcaaccgcga cagtgatgag gctacggagg acttcatgag 600 gcgcattgag tgctatgaga actcctacga gtcgctagat gaggacctgg atagggacct 660 gtcctatatc aagatcatgg atgtgggcca gagctacgtg gtgaaccgtg tggctgacca 720 catccagagc cgcatcgtat attacctcat gaacatccac gtgacccccc gctccatcta 780 cctctgccgg cacggggaga gcgagctcaa cctcaagggc cggattggcg gggacccagg 840 actgtcccct cggggcaggg agtttgccaa gagtctagcc cagttcatca gtgaccaaaa 900 tatcaaggat ctgaaggtct ggacaagcca gatgaagagg acaatccaga cggctgaggc 960 actgggtgtg ccctatgaac agtggaaggt cctcaacgag atcgatgcgg gcgtctgtga 1020 ggaaatgacc tacgaggaaa ttcaggataa ttatccactg gagttcgccc tgcgggacca 1080 ggacaagtac cggtaccggt accctaaagg ggagtcctac gaggacctgg tccagagact 1140 ggagcctgtc atcatggagc tggagaggca agagaatgtg ctggtcatct gccaccaggc 1200 tgtgatgcgc tgcctgctgg cctacttcct cgacaaggca gcagaacagc tgccctacct 1260 caagtgtccg ctgcacacag tcctgaagct gactcctgtg gcatatggtt gtaaagtgga 1320 gtccatattc ctgaacgtgg ctgctgtgaa cacgcaccgg gacaggcctc agaacgtgga 1380 catctcaaga cctccagagg aagcccttgt cacggtgcct gctcaccagt gaccatgttc 1440 atccactgtg accactaggc aggcactgct ctctgcagag ggggtcattc caggccctcc 1500 agtgtgtgtg atagtcacca tgccatgcag ggatattctt gaagccacac atggctggcg 1560 gaacccagag cccccacccc agcccacctg gctctttgtt gacagtcggc gacaaggttg 1620 tgcgtggctc ctgacctgct gctaagagtc acttgaccag actgcatctg catgggctgc 1680 gcggaggttg cccagcccca gtttcttccg gcgcagctct taggtgttca ctctcgccag 1740 ctcagttggc tttgtgaagt gtgaaaccct acaatgtgaa aggaaagtgc ttgctgtgat 1800 gttcctactg tggcccagct gcccagcatg gacctggtga ctctccacag ggcctctacc 1860 atcctctctg tggccacttc ctgagccaga ggccaggtct tcatggggcc ctgagcttct 1920 gctgcctctg gtgagaggga gagcccttcc catccttacc caccaggaac tagagcccca 1980 accacagcag atgcttcctg ggcagccact ggccaggccg ttgtatccat gtcaccctta 2040 gttgtgggca ttcatgaaag caatgcgctt gcttcagcac attggatgca cagaaacgtg 2100 agggcagggg gcagttgtgg tcgcccctcc ccagttgtgc atgtacccgg ctacttaggt 2160 atgcttaggg gagctggtgg ccaggggtgc cccttcaggc ctgctctcac agtgaaacca 2220 cttcaagaca gggcaggaag ttaccttccc tggtgcacac accgaagtgc tcgagggaga 2280 gctgccgccc cctctcccct tccctggctg tggacactgg cagccaatgg ggaggcggcc 2340 tctcccctgt tgctgcccgt gtccacacag gaatgtacac tggtggcaga aacatgcatt 2400 tgccataaat aattcagaaa caaaaaaaaa aaaaaa 2436 <210> 8 <211> 32552 <212> DNA <213> Homo sapiens <400> 8 tgttttgata tcagaatttc tggggaacat ttggatttcc agaatctctt tcacatcagc 60 tgtaatgtga gtgtgggcat agagctgtca agtattcttt ctctttagta ccaatataat 120 gtccagtagc tattaattat tccaaatcaa gtaaattctt gctctagtat gtgttagaac 180 aaaggttgaa ttctgatcaa tatgacacta atacctgtgc ccttaggcct tgctctaaaa 240 tgtcctcctt ccaatgcaga atgacacatt gccccaccct attccttgac actctttcga 300 aggaatattg gatgaaatca aatcaatttt ctatctggtg actggagctc tgggctgtgg 360 ttgcggagat ggtctggtcc cctctcctct tcatatccat ctgcttctgt tctataagcc 420 accttggtga gtttggaatg acacagttct cttgacgacc tgccatagca aatcagcaat 480 atctcaggat ttgggatctt aactaggaac tgtatgccac acatgtgtcc ctgccctgtg 540 atcacctctc tgggatgaca tgggtgtgta aacagaatat ccgaatagat gtgatgagtc 600 ctgcattgac ataagcatgg agagtgtgaa atagtctcag gaacattaga caaggctccc 660 ttgagaaggt gatttctaaa acctagacaa gaagatgaag aagtatttgt ccacacactc 720 catcctaatt tttatgtgcc attgccaatt ggacggaata ttatcaggtg aaataagaac 780 tggaaaaata aagggagggc aggcccacat taggagtggc caattgcctt ctggactgta 840 gcgatggatt gaaggtccag caaccccacc ccagggagac cctctcttct tttgggagat 900 cagtacgtga gtcctgaggg aactgttcag tcatttgcct tatcctttct ggcctgcttc 960 cagactctgg ggtccagatt ctggggtcct cccctaagct gcacaacctg cctccaggac 1020 tggaagtttt tggattttac actgctgttt acataaagta gtattgacta gaatttgcac 1080 aaatacattt tatattgaaa aatgatatag agtacttatt atgagctgga atccagtact 1140 actatgtgct gggtaaccag gagatccgag gtaacaatgt tttccctcca tgattccaag 1200 tctggctgga aagacattag gggaatctga agtaatgtag ccactatggt aagagtgggg 1260 tcatggtgag ggaggcacaa atgaagcaga gatcatttct ttggggtgaa gggatggtgg 1320 ttcaccctct gaatgtctaa gagacactga cattaaagct cagccttgaa atgtaatgtt 1380 aatgagacag aagaagtatt aaaagacatt tctggtagag gcagtagttt aaaagattgg 1440 tattgagaca tgaaatactg agatatattg atggggggta tgttgcgcat tcggggaata 1500 acagcagcaa ggtgaatagg agggattcag agagtgctgc acagagagga agtcaggcac 1560 ccacactttt gggaccctgg catgacggtt ctaagcagtg accagcagtc ccggtggagg 1620 agagaggagg acaacagggg aagatggttc tgggctggag atctgcaggg aaggtatggc 1680 ccaaggaaag tgggcaacag agctaagaga ggaaagagag caattctggg gtggatgatg 1740 gagggcaggc tgcatagaga aggcagcagg gggctgggag gagaaaatga aagcccaggg 1800 actgtaggtc tccgtgagtt ccaagaacag gtggaatgag aatgagaaag ggagagaagg 1860 aaagagaaga aaactaatgg tcagacatgg ggatttagag gtgaaaatgg cagatcagtc 1920 ctgaaggctg acgaggtgca gaatatgttc aggaaggaat gttcctgata aggagaggag 1980 atgctggtct gtgaatagag gtgtgagtgt ggagtggagc agtcattcca aagaacaaat 2040 agcccatctt acacactgct gctggtagga tggaaagaga atttttgaga tgtttgcctg 2100 attcctccaa gaagaatgtt tgcctgattg agaggttagc tggagactga ccagagtagt 2160 aagagtgata gggacacatg atgtgagcct caaggaagaa tactaagagc ggctgcacag 2220 aacattgcct ggaagtgaca ccaggtgaac actgaccctg tgttgtggcc tgcatggaga 2280 gacccgccag tgcactgcta ggacagcact gtgtcctgcc tgtttctgca tcctcagccc 2340 ataacacact gcctggcctg gagtagacta ccaataacaa actactccat tacctgcgag 2400 atagaggtgc tgcaatttct catcacagtc agcatgagct ctctgtgtca gtccttacag 2460 aatttccgtg atgctgcctt attccagcca gactgcttac ttggactcct ggaccactta 2520 gagctcctca aaatctggaa tattcattca tcaccagaaa cccagtcctg gcattgagca 2580 aaccatcatt taggacagct aagcatcaca gtgactcctt ctcacttcca cagggtcacc 2640 cacataggca catgcacaca agcacacagc acagggaaag gacactgccc ctggagcaga 2700 ggccacagga caaggaagcc catcctcagg gcactgctga gcctcccatt catagcccca 2760 agggcgctga acctgaagcc atccaggaat ccctatgtga gtggtttctg tttccccaag 2820 ccctggagaa cagctggggc aggagtggga gggcaggagc acactgagag atgccagctc 2880 cttctcagtg cagtatctga atgtgtctga atgaccctgg tccatgcctt gacaaggaga 2940 gcattgctgt gacctggcag gggccttcta ccaacttcca cctggaacct gccaaggtgg 3000 ctgcatttag ggaacggtgc agaggcagac accaggacct gtgtgagagg cagatcagct 3060 ctgctggagg ccataggggg aacgttgctg gagggacatt actcctgggt gacccactgg 3120 atgggggtgg gggaaattct ccaacaaagt taacctggaa ttggtagttt tgacaatgta 3180 ggtcaccaaa gagaagaaga aataaggcaa gtgtctggtg ggaggagaca cttattgttc 3240 ctggggtctc tggaggcccc ttggtggggc tggatcactg gcttccccca gaacagggcg 3300 ccgctccatg gctctgcttg tggtagtctg cggctatgtc tcccagcaag gacagaaact 3360 cagaaaaatc aatcttctta tcctcattct tgtccttttt ctcaaagaca gtggcgaggt 3420 aatgtatgcc ctttttgtcc tgtgaagaga aaaacataca aaatagaaaa attcaatcac 3480 aaacaagttt tgggctggga ggggagagga ggaggcagag atacagacaa gtacctagat 3540 ctgcacaggc atggtcgtgg ggctgagagc acagggtgag tgggtgaagt tggggtgagg 3600 acgtgagtgt tatccctgga gttctctaag gagacttttt gtctcacacc tcaggatggg 3660 aggcaggtcc tgtcccgagg cactctgtta agtgaccttg gggagagcag tcccctgccc 3720 cagcctcaat cttgcctgtt cccagcattt aagggcactg cctaccttag ttctacccca 3780 gggcctcaaa attggccctc atgctttgtt ctcttctttc tctgacctcc tctcctttct 3840 tctccttttc caccaaactc atcttctggg ttccctactc ttggtcatct agaccctttg 3900 gtacctagta gcccacaggt tttttcagat ttgccaatga gttttcttta ttgcaaagag 3960 ggctattgat ttctactagc aatggaactt ctagtgcttt cccagtaatc tcagggatgt 4020 tgatgtgggg cctttgggaa gcaggacctg agcatgtgag tttcagtctc acagagagag 4080 ggtcagtgag cgctgggagg ggactgtgca ctgtcctcaa gctgcacact ttgctgacca 4140 tctaataacc tcctttatat ctgtataact ctttcccatt ttcatacttt ttcgcctacc 4200 atccttagat tcacatatga tccaagcaat aaagccctat ttgcaaatgg gaaacttttt 4260 aatcagagga tgagggtgac ctgtccaagg ccacatagca aaatgtatcc tcagccatgc 4320 cagggtccaa ccaacattga gaagctagac cccaactcac acaggcactg aggaaattgg 4380 ggaagttctc cttcatcatc gtcagcaggc ttggcttctc aatcttgcca tcacgtccgg 4440 tgtatttgtg aaacatgtcg atcatgccta ttatggacct ctcagcttga gtgttgctca 4500 tctttgcttt caaaaagcct tcaggaaata aagacaatca tttcttacct tagtttgaat 4560 taaggtctct atgtgggggt gttagaagga gggctgagga cagagtaaaa acagccctaa 4620 gatggagcag aaggaacttg atttttttaa atgtgatggg ataagttgtt caaaaatgag 4680 agggtaggac caagtctgag acccggccca tcctggccag ggccaagaag agatgcaggt 4740 ggatggcaga agtccagctg tggacagtgc ttcagagaag gagaagcagg gagagtcgga 4800 ggccagcaac acatagaaga actaagctgg gaccccccag cctcaaccag cacatggcgg 4860 accccactct tgaaacagca ccaaatccat ctcctccagc ttcacagtcg gggtgagagt 4920 cacgggggca ggacaatggc cttggtgatc tggtgtctga ccctcctcgg ctgcttcagg 4980 aaccagacac cgtgggcccc accttgactc aagtgcaagc cctgcatgac acagtgcgtg 5040 caggctccag gtgcacatgt gagcgtggac atgagtgtga gcaggaaaca cagccctctc 5100 ccgaggacag ggggcccttc ctacattccc ttgggaatga gaaacaagaa ttgcctctgt 5160 tacaaggaac agaaataact ccctggttct taagctgctg gatggggtgg gagtgaggtg 5220 ggagtcgctt catgtctgct cttgggaaat atctgcaccc tctgaatcac caagggttga 5280 ccctgtttaa ataaaaatgt ctgactttcc aaagcagatc ttccagccag tagccagcct 5340 gggctgccct gcaccccaag cctgaaaaat aagacagtgc agctctcatt tctacacttt 5400 ccaaagaacc agaaaaggac cttggctaac gcatgtgggc atctgacaat aaacccccaa 5460 cacctctcaa cgcaggagaa agctccgtgc cagcaactga ctaagagaag ccactcaaag 5520 ctttctgaat ctgaggccaa ggccaaggcc agaggccaag ccctgtgccc agagattgac 5580 tgagaattta caggtccaag gcctgggggt ttggagagcc tccaaagcat tcacagggga 5640 tccttatccc tcctccctct gtgggggcag agctggggag gggattcagc aactgggatc 5700 ccaaaaggag aatgaatcca gggaggaaga agacaggaag gaaagggagg gtcctgtgct 5760 caggtcccac tggggacatt tccacaggag ttgtctcagg agatcccaaa ggagcaatgg 5820 acaggtctgg ttcagccacc tggttgtaca gacgtgggct tttggggtca agtgaaggtc 5880 acacagccca gctaatggca gagctggcct agacccaggc ttctgagact ttgtccacag 5940 ccctttccct tcctacaggc agcatggcag gctgggcact gggcacttct agaaaatgca 6000 aagaggcagg tgagacttac cagaactggg aagtgtcacg agtagaagga tgagtgagat 6060 gtgtgtgttt ggacaaagag cagtccttta taaggctcag cctggctctt cccacgggtt 6120 gggaggcctg gggccacctc tgtcatctgt ttcttggagg cttgtcccat atcaggtgtg 6180 tgggacacac ccaggaggct gtgctcagga tttctggcca gggtcccagg tcaccaggtc 6240 ccaccccacc ccagagacct cacctggggc cttctctggc tcaatcttga tttgagggta 6300 aggcagcggt acatgtgtag taacaggtca ggaaatggga gaaaagagca ctgggcctct 6360 ggacccaaag agaatggagt ttcagactcc caaaggcagc atggtcttgt ttattccctc 6420 ccccagtact tccacacatt tgttgtgaca gcctgttcta tgacccccac cgcttactga 6480 gcgttttaat gtctagacat caagacacct gctgctcttg catcctcctc aaccctcccc 6540 tcatagtctt aagaagcagg tgctgcaatc tctattttag gaaaggagaa gttgagatgt 6600 tcccaagttt actcagctag taaacacaac aaatcatcac acgaacaaag aaaagcctga 6660 atcaaatcct tactcttatc ccctgtgcta taggtcttgg gttgcatcag ggtctgccct 6720 atgggaactc aaagtccagg gagggaagca ggattacttc attgctaacc attggtcagc 6780 ccctcacaga agccctggat ttaggtgggg ggactggggt caggggcctc actatctagg 6840 ttgagtggtg gagtgacccc cgcccccccc gccccatgga atgagcctgg aggtagggag 6900 tgggaaaagt tctttcctgc cccatggcac taacttccca gaaagtcttc agtgtttttc 6960 ctcctcctat gcaaaacagc ctgtgtagga gttgggagtt gtgcccttgg ctataatgtg 7020 ccctaacctg ctgtggaaag cctgaaccag gtaggggcaa gagggttggg aaggcacagg 7080 agtccctggg gcatggtgag gaaaaggaga tgatgaatca ctgaaatgga ctttttctgc 7140 taccccctta caatgttcct tgtaggccgc aagaggtcct ggttcattta gtgccagccc 7200 tttaagcact ctggggctcc atagagctga tgtgatgtct ccctaggtgg gacctatttt 7260 ctccacccat catctttctt caacttcctt ctctgtcagt tcttatgtaa ccagggggac 7320 ctgtttctcc ctctcccagt ttcccatatg acggcaatat tacttttagc ggcaaaagat 7380 acacacacac acacacacgc acacacacac aaacacacac acaaacgcac acatacacac 7440 acacacagac gaatactact caaccataaa aagaatgaaa tgatgacttt tgcagcaaca 7500 tggatggaac tggaggctat tatcttaagt gaaattactc agaaaaagaa agtcaaacac 7560 tgtgcaccct catgtgtaag tgggaggtac atcatgcata cagatggagg tagagagaga 7620 gtagaatcat agacactgga gacagtgaag agcaggaggt caggtggtgg gtgaaggagg 7680 agacatttct tagtgggtac aatgcgtgtt atttaggatg gctgcattaa aagcccggac 7740 ttcaccactg tgcaatgtgt tcatatacat gtgtatgcag gtttttgtgt ggacataagc 7800 tttcagttct tttgggtaaa tcccgaagag tgtgatttct ggatcctatg gtaagagtat 7860 gtttagtttt ttaagaaagc accaaactgt cttcccaagt ggctgtacta ttttgtgttc 7920 ctgccatcaa tgaatgagag ttcctgttgc tccacatcct tctttagcat ttggtgctgt 7980 cagtgttcca gattttgggc attctcataa gtgtgtactg gtatctcatt gttgttttaa 8040 tttgcatttc cttgaggaca tatgatgtgg agcatcagct gatatgctta tttgtcacct 8100 tctgtatctt ctttgatgag atgtctgtta aggtctttgg cccattttct aattgtttgg 8160 tttgtgttct tatctctgag ttttaagagt tctttgtacg ttttggataa catacaaagt 8220 ctgatatgtc ttttgtaaat attttctccc agtctgtggc ttatcttttc attctcttga 8280 caatatcttt cacaaagcag aaatgttaaa ttttaaagaa gtccagctta tgaattattt 8340 ctttcatgga ttgtgccttg gtgttgcatc taaaaagtca tcaccaaaac caagatgatc 8400 aaatttcctc ttatgctacc atctaggagt tttgtaatat tatgttttgc atgtaggtct 8460 atgattcatt ttgagttaca tatcatcact gtttataaaa aaaaggaaca gaagaaatgc 8520 aatacaaaag gaatcaggga caacaatatt aatacaagac aacaaagaat tctaagaaaa 8580 gggattaaat gaaaaagaag aatatttcct attgattagt gtgcaagtca ccaagatgca 8640 atagtcttat cttttttttc tttcttgttt tttctttttt atgagacaca cttttgctct 8700 tgcagcccag gttagagtgc agtggtgtca tcttggctcg ctgcaatctc ctcctcctag 8760 gttcaagcga ttctcctgcc tcggccttct gagtagctgg gattataggc gcctgccact 8820 atatccagct aatttttgta tttttaatag aaatggggtt tcatcatgtt ggccgggctg 8880 gtctcgaact cctgacctca agcgatccac tcatctcggc ctcccaaagt gctgggatta 8940 cagttgtgag ccactgcacc tggcaatagt cttatcctta tatacacaag aacataatat 9000 tgaattatac aaagcaaaca ttgaaataaa ttaatgaaaa ctgacaaatt tatatcactt 9060 ggcagtttct ggcagagtct gcccaggaac tcaacagagt cgtcagataa caaaacacca 9120 gtaatggtgc agagcagggc gggcagatgc tgccacagcc cagaagcagc cctggacata 9180 agggccccgt ggatgaagac agctgtttct agtaaacact aatctccaga attggttggc 9240 cagctggatt tggctttaag accataattt gctgattcct gatacaaaat atttgaagga 9300 cacacttaaa tttatttata tacacgtgca ttcataaatt tgtgcctgac catagagaat 9360 acatataaat ttcttttttt gtattgaggt tctttattaa attaattata taatctgtat 9420 tagataatta acgtttttac aaaaattatt attatacttt cagttctagg gtacatgtgc 9480 acagcgtgca gtcttgttac atatgtatac atgtgccatg ttggtgtgct gcacccatta 9540 actcgtcatt tacattaggt atatctccta atgctatctc tccccgctgc cccaacctca 9600 cgacaggccc tgatgtgtga tgttcccctt cttgtgtcca ggtgttctca ttgttcaatt 9660 cccacctatg agtgagaaca tgtgatgttt ggttttctat ccttgcgata gtctgctgag 9720 aatgatggtt tccagcttca tccgtgtccc tacaaaggac atgaactcat ccttttttat 9780 ggctgcatag tattccatgg tgtatatgtg ccacattttc ttaatccagt ctatcattga 9840 tggacatttg ggttggttcc aagtctttgc tattgtgaat agtgctgcaa taaacatacg 9900 tgtgcatgtg tctttatagc agcatgattt ataatccctt gggtatatac ccagtaatat 9960 gatggctggg tcatataatg gtatttctag ttctagatcc ttgaggaatc gccacactgt 10020 cttccacaat ggttgaacta gtttacagtc ccaccaacag tgtaaaactg ttcctatttc 10080 tccacatcct ccccagcatc tgttgtttcc tgacttttta atgatcgcca ttctaactgg 10140 tgtgagatgg tatctcattg tagttttgat ttgcatttct ctgatggcca gtgatgagca 10200 ttttttcatg tgtcttttgg ctgcataaat gtcatctttt gagaagtgtc tgttcatatc 10260 ctttgcccac tttttgatgg ggttgtttgt ttttttcttg taaatttgtt tgagttcatt 10320 gtagattctg gatattagcc cttcgtcaga tgagtaggtt gcaaaaattt tctcccattc 10380 tgtaggttgc ctgttcactc tgatggtagt ttcttttgct atgcagaagc tctttagttt 10440 aattagatcc catttgtcaa ttttggcttt tgttgccatt gcttttggtg ttttagacat 10500 gaagtctttg cccatgccta tgtcctgaat ggtattgcct aggtttcctt ctagggtttc 10560 tatggtttta ggtctaacat ttaagtcttt aatccatctt gatttaattt ttgtgtaagg 10620 tgtaaggaag ggatccagtt tcagctttct acatatgggt tagccagttt tcccagcacc 10680 atttattaaa tagggaatcc tttccccatt tcttgttttt gtcaggtttg tcaaagatca 10740 gatggttgta gttgtgtggt attatttctg agggctctgt tctgttacat tgctctatac 10800 ctctgttttg gtaccagtac catgctgttt tgattactgt agccttgtag tatagtttga 10860 agtcaggtag tgtgatgcct cccactttgt tcttttggct taggattgtc ttggcaatga 10920 gggctctttt ttggttccat atgaatttta aagtagtttt ttcccaattc tgtgaagaaa 10980 gtcattggta gcttgatggg gatggcattg aatctacaaa ttaccttggg cagtatggcc 11040 attttcacaa tattgattct tcctatccat gagcatggaa tgttcttcca tttgtttgtg 11100 tcctctctta tttcgttgag cagtggtttg tagttctcct tgaagaggtt gttcgcatcc 11160 cttgtaagtt ggattcctag gtattttatt ctctttgaag caattgtgaa tgggagttca 11220 ctcatgattt ggctctgtgt ttgtctgtta ttgttgtata agaatgcttg tgatttttgt 11280 acattgattt tgtatcctga gactttgctg aagttgctta tcagcttaag gagattttgg 11340 gctgaggcga tgggattttc tagatataca atcatgtcat ctgcaaacag ggacaatttg 11400 acttcctctt ttcctaattg aatacccttt atttctttct cctgcctgat tgccctggcc 11460 agaacttcca acactatgtt gaataggagt agtgagagag ggcatccctg tcttgcacca 11520 gttttcaaag ggaatgcttc cagtttttgc ccatttagta tgatactggc tgtgggtttg 11580 tcataaatag ctcttattat tttgagatgt gtcccatcaa taccgaattt attgagagtt 11640 tttagcatga agggctgttg aattttgtca aaggcctttt ctgcatctat tgagataatc 11700 atgtggattt tatctttggt tctgtttata tgacggatta catttaatga tttgcgtatg 11760 ttgaatcctt gcatcccagg gattaagccc acttgatcac ggtggataag ctttttgatg 11820 tgctgctgga tttggtttgc cagtatttta ttgaggattt tcccactgat attcatcagg 11880 gatattggtc taatattctc tttttttttg ttgtgtctct gccaggcttt ggtatcagga 11940 tgatgctggc ctcataaaat gagttaggga ggattccctc tttttctatt gattggaata 12000 gtttcagaag gaatggtacc atttcctctt tgtagctctg gtagaattcg gttgtgaatt 12060 catctggtct tggacttttt ttggttggta ggctattaat tattgcctca atttcagaac 12120 ctgttattgg tctattcagg aattcaactt tttctgggtt tagtcttggg agggtgtatg 12180 tgtccaggaa tttatgcatt tcttctagat tttctagctt atttgcatag aagtgtttac 12240 agtattctct aatggtagtt tgtctttctg tgggatcggt ggtgatatcc cctttgtcat 12300 tttttattgc gtctatttga ttcttctctc ttttcttctt tattagtctt gctagtggtc 12360 tatcaatttt gttaatcttt tcaaaaaacc agctcctgga ttcattgatt ttttgaaggg 12420 ttttttgtgt ctctatctcc ttcagttctg ctctgatctt agttatttct tgccttctgc 12480 tagcttttga atgtgtttgc tcttgcttct ctagttcttt taattgtgat gttagggtgt 12540 caattttaga tctttcctgc tttcacctgt gggcatttag tgctataaat ttccctctac 12600 agactgcttt gaatgtgtcc cagagattct ggtatgttgt gtctttgttc atattggttt 12660 caaagagcat ctttatttct gccttcattt cattatgtac ccagtagtca ttcaggagga 12720 ggttgttcag tttccatgta gttgagtggt tttgagtgag attcttaatc ctgagttcta 12780 gtttgattgc actgtggtct gagagacagt ttgttataac ttctgttctt ttacatttgc 12840 tgaggagtgc tttacttgca actatgtggt aatttttgga ataaatgtga tggaataaat 12900 gtgacgtggt gctgagaaga atgcatattc tgttgatgtg gggtggagag ttctgtagat 12960 gtctattagg tctgcttggt gcagagctgg atatccttgt taactttctg tcttattgat 13020 ctgtctaatg ttgacagtgg ggtattaaag tctcccatta ttattgtgtg ggagtctaag 13080 tctctttgta ggtctctatg gacttgcttt atgaatctgg gtgttcctgt attgggtgca 13140 tatatattta ggatagttag ctcttcttgt tgaattgacc cctttaccac tatgtaatgg 13200 ccttctttgt cgcgtctgtt ctttgttggt ttaaagtctg ttttatcaga gactaggatt 13260 gcaagcactg cttttttttg ctttcctttt gcttggtagg tcttccttca tccctttatt 13320 ttgagcctat gtgtatctct ccacctgaga taggtctcct gaatacagca cactgatggg 13380 tcttgactct ttatccaatt tgccagtctg tgtcttttaa ttggagcatt tagcccattt 13440 acatttaagg ttaatattgt tatgtgtgaa tttgatcctg tcattatgat gttagctggt 13500 tattttgctc gttagttgat gcagtttctt cctagcatca atggtcttta cagtttggca 13560 tgtttttgta gtggctggta acggttgttc ctttccatgt ttagtgcttc cttcaggagc 13620 tcttgtaagg caggcctggt ggtgacaaaa tctctcagca tttgcttgtc tgtaaaggat 13680 tttatttctc ctccacttat gaagcttaat ttggctggat atgaaattct gggttgaaaa 13740 ttcttttctt taagaatgtt gaatattggc cccgactctc ttctggcttg tagagtttct 13800 gccaagagat cctctgttag tgtgatgggc ttccctttgt gggtaccctg agctttctct 13860 ctggctgccc ttaagatttt ttccttcatt tcaactttgg tgaatctgac aattatgtgt 13920 cttgtagttg ctcttttcga ggagtatctt tgtggccctc tctgtatttc ctgaatttga 13980 atgttagcct gccttgctag attggggaag ttctcctgga taatatcctg cagactgttt 14040 tccagcttgg ttccattctc ctcctcactt tcatgtacac caagcagact tagatttggt 14100 cttttcacat agtcccatat ttcttggagg ctttgtccat ttctttttac tcttttttct 14160 ctaaacttct cttctcactt catttcattc atttgatctg caatcactgc taccctttct 14220 tcctgttgat caaattggct actgaagctt gtgcatgagt catgtagttc tcgtgccatg 14280 gttttcagct ccatcaggtc atttaaggtc ttctctatgc tgtctattct agttagccat 14340 tcatttaatc tttttttcaa agtttttagc ttctttgcga tgggtttgaa caaactcctt 14400 tagctcggag aagtttgtta ttactgatca tctgaagcct tcttctctca actcgtcaaa 14460 gtcattctcc atccaacttt gttccgttgc tggtgaggag ctgcgttcct ttggaggaga 14520 agaggtgctc tgatttttag agttttcagc ttttctgctc tggcttctcc ccatctttgt 14580 ggttttatct acctttggtc ttttatgatg gtgacgtaca gatggagttt tggcgtggat 14640 gtcctttctg tttgttagtt ttccttctaa cagtcaggac cctcagctgc aggtctgttg 14700 gaatttgctg gaggtccact ccagaccctg tttgcctggg tgtcaccagc ggaggctgca 14760 gaacagcaaa tattgcagaa tggcaaatgt tggttcctga ttgttcctct ggaagctttg 14820 tctcagaggg gcacctggct gtatgaggtg tcagttggcc cctgctggga ggtacctccc 14880 agttaggctg cttgggggtc aaggacccac ttgaggaggc agtctgtcag ttctcagatc 14940 tcaaactccg tgcttggaga accactactc tcttcaaagc tgtcaaacag ggacgcttaa 15000 gcctgcagaa gtttctgctg ccttttgttc agctatgccc tgcccacaga ggtggagtct 15060 accgaggcag gcagacctcc tttagctgtg gtgggctcca cccagttcgc gcttcctggc 15120 tgctttgttt acctactcaa gcctcagaaa tggcgggcac cctgccccca gcctcactgc 15180 cgccgtgcag tttgatatca cactgctgtg ctagcagtga gcgaggctct gtgagtgtgg 15240 gactgtccga gccaggcacg ggatatgatc tcctggtgtg ctgtttgcta agaccactga 15300 aaaagcacag tattagggtg ggagtgacct gattttccag gtgccgtctg tcacggcttc 15360 ccttggctat gaaaagtatt ccctggcccc ttgtgcttcc tgggtgaggt gatgctcacc 15420 ctgcttcagc tcatgctctg tgggctgcat ccactgtatt gctcccactg tctgacaagc 15480 cccagtgaga tgaacccggt acctcagttg gaaatgcaga aatcacctgt cttctgcttc 15540 gctgggagct gtagactgga gctgttccta ttcggccatc ttggaacctc tccaaaaata 15600 tcaaacatat ttgagacatc caaaaaactg atcatttgtt tttgctaaaa tcaaaatctt 15660 agcaaattag ctttaatagg ggccttatct tttgcacctg ctcatcaggt tgaaccctgt 15720 gagcctttcc cctgtgtcat gtctggaaca aacactctcc ataaacccac cccatcctat 15780 cacacatcca acctcccagc cactgctgat cccccaggag agctcacaac aggctgattg 15840 tgaacaggaa tttggctggt tgatatcttc atctcctcta tcgttttggg gagctcgcct 15900 ctccccagcc tgaagtagaa gcaacatact cctgggtctc tagaagatct caagttgctg 15960 ggggaagagg acagaaagca atttgttctt tttgctgtat tttatccatt catttatgct 16020 gtgagtgctg actctgttct gggtgtgcag gtgtcagggt ggcagggaga tggagtggat 16080 gtggaccatg ctttgagcaa tgctctggcc ccaggagaga actccaatat aaggcactgg 16140 gtggtgagag agtagagtgg gacagagccc ggaagccccc aggtccccag gcagttcagt 16200 ggtcactttc tctgtgaagc cttctccagg cagagccatc atccccatgt ccctgcatgt 16260 ctcagtgaca gccctggcca cacatatgct atgtttgctg ccgcccagcc atgtcttata 16320 ttgtgccccc agcctccagt gcagagaact ccataaacat tggccaaact agcaagtgag 16380 gcaggtgtct tcaaaaaggt tcagataaag tgtgtgggaa tttggaagag gagaaatcac 16440 ttttcaggtg ggggaaccag gggaagcttt gtaggggcat cctttcaata ggccatagag 16500 cacttccagg agccacggtg agagggacag ggcagaggga gccacgggaa tgttccaaga 16560 cagccagctg ttctgtttgg ggtccttctg ggtggtgctg gccagctgca tctctggact 16620 cgtgcagcag ttgggggagc gggacagaga gacagagaga gagttctgca gcattcacaa 16680 gaggttatta ggactcagtt ctgctgtgag ccatccacac tggaggatga gaacacccag 16740 ctgcagccca gagcctgtgg tcccactgtt aggttttgaa gggaaggcaa gggttaaaaa 16800 aagacacaga gagagttggt ggctctatgg aaatgcaggt tttatgtcca gcacaagacc 16860 tgaggaggtg ggggacaagc ttaatgccag agccccctgc cgcttacagg ctggggtaat 16920 ttataggtct aggtgggggt ctgggcagta tggctagctc gccgggagga tattgataag 16980 atgttcctgt gatcaggcgg tttggacctt tttccagcgg gatgtgatag gctgtttctt 17040 ggacctttgc cccgcaggat atgatgggga tgttccttca gttgcgcctt tgcccagcag 17100 ggtatgataa ggatgctctt gtgccttgcg gtcaggtggt taggcaggat gtttctcacg 17160 gcctgaatcc acatggaatg tttcactctg accagggtcc gcaaaatggc agggggctta 17220 caaaatggtg cagtttggac taacacccac catcctgtcg aatgggtttg ctgggaggat 17280 ttactgtcaa ttctgttagc ctgataaggg aggttgcttt ctcggaggcc gcatacacag 17340 acagtgctag gaagtgaccc aagcgtaccc tgagaaatgt atctgttcaa ccaaatttca 17400 agttggcaat gatcattcct catctcgccc aattttaaga cgaggctggg ccgtgtaggt 17460 aaaactggca agctggagaa agcagtgcgg ggtggggggg actccaggaa ggctccttgg 17520 ccaaggagga ctgtaggatt ctgacttaca ctgtaagggc tgttcctgtt acagttggcc 17580 ccagtcagag gcccaggaca aaactctggc cctgagtgca gagaattggt tttctgtttc 17640 ccaagcttcc acacggtggc gccaccgagc acccacctcg ccctggttgt cgccggaggc 17700 agtaccacgt ggctgggtcc ttcgtggttc ccgcccttct gtaggttgtg agtcccacgt 17760 cgggcaccaa tcttgcacct gttaaaaaaa gagatcttca ccaaaagctt ctgaaaggca 17820 gagggctttt cttacttaat ttgtattctt ttctctctcc aatgcttacc agaggacact 17880 gcataaaata gtatattggg gacacaattg ttaatcaagt ggtagaaaca ggaagagata 17940 aaaataatta aatttttagt aatggtgggt taagtaaatc ttgatgccta tacacatgga 18000 atccctgtga tgatacgaaa tggacatttg gtctttgtcc ctgttcctga caccgagcgt 18060 ctgaaatcct tggaatctcc tgaatgacag gggagaggga gcatcttttg ttattcataa 18120 caatcccctt ccagtcatgc tgagtgtgtg ctaatgaggt gactcttggt ggacccctag 18180 atagcttcag gatggggctg gttgccagag gaagcaacca tgtgattaga gggctggagc 18240 tttcagcccc acactgggcc tccacagagc ggctggggaa ggacttcaat caccagtggc 18300 caattattta atcaactatg cctaaatgaa gtgactgcca tagaaacccc aaacgatggg 18360 gttcagagaa ctgtagggct gctgagcagg tggggtgccg gaagggtggg ctcctggagt 18420 gggcctggga gctccatgct gcccctcata catggccctg tgtgtctctt ccacgtggct 18480 tttcctgagt tgtactcttt gtaataaacc agtaatcatg agtaaagtgc ctccctgagt 18540 cctgtgaact cttgtagcag attatctaac ctgaggaggg ggtttgtagg aacctccaat 18600 tttagccagt cagtcagaag tatgggcggt caggtgctgc gattggcatc tgcagtgggg 18660 gcagtgttgt ggggctgagc cttcaccttg tggggtctgt gctaactctt ggtagttagg 18720 atcagaacgg aattgcacga taccccgatg gtgttcagag tgttggagaa ttggttggtg 18780 tggggatttt aaaaaaagga aatataaccc ccacacattt ggcgtcaaaa gtgttgttag 18840 tcagaatggt tctggaattc catataatgt agctatttgg aatcaatcac tcaaaaatat 18900 ttaagaactg gggagatgtt ttaaacatag tcctaattga aaaagcagat cataaaacag 18960 ctgggaaagg gcagggccgt ggcccacagg gtggacgtgg agtgggggtg gggagggggt 19020 taatgtgaca tgattgctcc acatgagaca aggccacgga actcaggaaa caaagcttgt 19080 tttgagcaag agtcgtgtca gatttcgaca ggaggtagag cagagagaag atatctttac 19140 ataggtgaag ctaacagttc atgataaagt gttctcagcc ttcacattca cagtcaattg 19200 attttcaaca agcccgccaa gccaattcaa tggagaaaga atagtctttc caacacatga 19260 tgctgggaca agtggacagc cacatgcaaa ataatgaagc tggacccctt ccttccttca 19320 tacacacaaa ttaactcaga ataggtcaca gccctacaca taagagctaa aactaaaact 19380 cttagaagaa aatatagaag taaatcttca agactgaggt cttgaatatc tttgcatatg 19440 ctactgaggc tttatgactt tactttccac agttagacct acaatccact tggaattgtc 19500 attttgtctg cttgtgtggt ctagtttcat gagcatgagc atccagttga tccagtaaaa 19560 tgtattgaaa agcttgtgct cagcagtgcc acttttgtca cagaataaat ataccatacg 19620 tgtgtgtctt tttctcagac ctctatttag ttctgttgat ctatgtgact gtccttgaac 19680 cagccaggca gtatcttagt taccggagct gttatgataa atcttaacat ctagtactgt 19740 agatcctccc atgtcttttc tttttcatga ttcccttggc tattcttggc ctgtctatat 19800 actttttaca gttaacttgt caatttctac aaaaattcca gcaaggactt tgggactggg 19860 attgcactga atctataggt tacgtttggg agaactatca gctttacaat agcatgtaaa 19920 gctgctatga acatggcata tcccttacta aaaactttta gtggcttccc atcctgctta 19980 aagtccaaat tttgcaaagt cctcgttggc ttgtcctctg cctgcccctc agacctcatc 20040 tcctgtcttt ctgggctcca tttacaccac tccagccctt ctttctgccc ctctgtcagc 20100 ccaggctggc tcctacctga gcacctctgt tccagctctt tcctctaacc atggggccct 20160 tctcctgctc tccctaaggt tggatttcct gttattcggg gacaaggtaa tgtagtggtt 20220 gagaacaggt atgtggggcc catgggcctg ggttagaaat gtgcctctgc attactagct 20280 gtgtccccag catgctcctg taattgtcat tccttgggct ttttcagcaa ttgttaagaa 20340 gatgagatga atgggtggat gtaaagccca tggagcagtg ctcagcaaag aggaagaact 20400 taatactgtt aatcatcttc tcactctcca gcagcctcct ggtcctacag aagcagccta 20460 gggactccct atgctcaaat cctattcttt ttctctacac ggcaataatg taccctttct 20520 ttctctttat cacattttct gtgaggattc taatgcatct agcagctccc ccttcaagca 20580 cagcccatct aacacacatt tcagatactc ttgaggctgt tgactgggat atcaggttgc 20640 tctaatccta aagataaaaa aggtctggaa aaaagaaaat agatatacac tggtaagaac 20700 tggcaaaaat ccctaaatat tccatcagta taacccgatt catcgtctca agtaccatat 20760 gagatttctt taatttttaa ggtaattact tgatcctctt caccaccacc tcaccgccct 20820 cttagtcaga aattgaatat tatcctgctt gaagtatttc caattcttga ggtgtctaaa 20880 accctgggtg cggccgaagc ggggatgggg gtgcttcagg gccagtttcg ggtaacctcc 20940 tttctcaatt tcaccagaaa gcgctactcc tttgctgtac tggcttctgg atgtcacggg 21000 acattgtttt cagtgtctgg tctgcacact ggaaagacat gaagactgtg tttgtcaaga 21060 tcacaatctt agtcctggcc atgggtggtt gggttgtgac atgggagatg catgcttggc 21120 accatgttta tggttctttt ctaagtacag taacctgaag ttttggccaa atgtctgtct 21180 ccacctacag actatgagtt tctggaaggc agaatgttat tcaattcatt tccgccccct 21240 ttctccacag cacctagcac aggtgcacct agcacctaac acgtggcaaa attctgataa 21300 acattaagga agagttgaca ttaaaatgta taaataaaag taatttaatg tctaacaata 21360 atggattcat aagacaaatt ttgataaatg caaacagatg atcgctatgt actcgccaaa 21420 aatcaggcta gcattgatta agcatgtgag atgtccacag cataacatta agcaaaaagt 21480 gcagttacag cgcagctgtg caagggatca tcactgggta ttggcatggc gtagggggct 21540 gttttgtccc agagtgaaca aaaggtaggg tgaaaaggag tgcagtctgc cccccatccc 21600 cagccatagg tcagaaatga agtttcttct aaacaacaag ctgttatcca gcaattgtcc 21660 aacagtaagc catatgggta taccaaattt gttaattaga tagttttaag gttttgcttt 21720 tatttttgtt tcttggttat ggatattgca atggtggaca ttttcctgat gatttttaaa 21780 atatctgttt aattaattgt tttgggagaa attgccaggg taatgatggc tgaaccaaag 21840 aattcgatac aattttttgt agctctagct tggcaatgct gagaaattca agccatgttt 21900 ttagtttaga aacaggaaag tgtattgatg aaccacttgt ttgctgggga aatctttatg 21960 ttgagtagat gaaggctcac ccagcaaact ggaaaagctg ttggcttcgg tatctaccta 22020 tgattttctc tccagccttc agagatgcat agatggagtc tctggtttga tgacctgccc 22080 tttggcgccc cattctggaa gattcagtca tcagcctgtg caggccctcc caagggagct 22140 gtgtggggtg aaatggggcc aagtagaagg ggccggctgg gagaagtctt gtgttggggt 22200 gagttggcag aggggacccc acctgtcact cactcagggg cccaggtagc atctgtaggg 22260 atgtcgagcc tgaaggtctg gcccctctca gagtagggtg acttccacat tgcagtcggt 22320 gatttactag taaacaaatc tggttctacc acttctcttt cacctcccgt ccatcaccca 22380 actgatttaa aaaatcctct attagcttcc tctcttgttt gtgtatcaca gtcttgccct 22440 ggccatgggt agtgggggtt gtgaggtggg agatgcgtgt ttggcaccaa gtctgtggtg 22500 cttttctaag tacagtacct tggagttttg gctagatgtc tgcctccact gacagactat 22560 gagctggata ggataaagtc acagttgtag cttggcacag ggtcttccgg tcttgtctcc 22620 ctcctgcctc tccagccttg tttcttctaa cttctcattg tgcaccctgt ggactccatc 22680 ccctgagggg gccgcgctct tttacagccc cgggcctttg cctgtgccat atcctctgtc 22740 tagagtgcct ggttctcctt tcctccttgc aactcaaaat gtctcttcaa gtcgcagctg 22800 aaatatcgcc tccctaagga agtccccccc aactccccag gtggaaggtg tccctttctg 22860 ggtgcctgga gcacctgtct gtgtcactca gttggcttcc atgtgcctag tgacagtgtg 22920 tgactgtccc ctcacatgtc cccaccctgt gagctggccc tgtatctgat gcatattgcc 22980 tagcagaagg cctggcacac tgtaggtact caagaatatt cgttgaatga atgaaggaat 23040 gaatgtgctt catgacagtg gagtttgggg gttcactaat ggagggagga caccccaggg 23100 agatgtagtt aagtgtgtgt ctgaccccac ccaagccctg gagctgagag gacaagctct 23160 gaggcaggga gacagataat gggacctttt gtgattctta gatgcttcag atcctgctcc 23220 aagggatgtg ggcccctgaa actggttgag ttaatcttag caagttaagt gttgtgatgt 23280 cacctcagga atgcaattaa ggctcagtcc tgctcctgaa ggacctgtga agcatcacaa 23340 cactggctgc cataattgga ggcattgagg atgggtggga tgtggggctt ggtggtgggt 23400 tcgcggctca cacaggtgcc tcctgcctga gcgttgggga atctctggga tcaactacag 23460 gctggatctg tggatttgga tactcacccc aacagtgaca ggtcagtgcc tcttccaaga 23520 gaattgtggg ggtgagggtt tgtgttggat ctgtgcaggt tctaaaaagc agaggtgggg 23580 acagtttacc tgtttggaga acacgtacag tgtggatggg catcccaaca gcacaatcgt 23640 ggcccaaggc gggtgtagga ctggaactga aagcatgcct ttgggcttgt tcccaaagac 23700 atgggtttga acgaagctcc aagtggatca ttgtgtgatc ttggggaaat tacttatcct 23760 ctctgggttt catttccccc ttaggaaact gggggtaaat atgcttgctt tctatggccc 23820 acgtgagggt tacgtgggat acgggataat ttgtataaag tgcttacctg gtgcctggct 23880 ggctccatga gcggtggaag cagcagttgt cctgattcct atctgtagag tccagggagc 23940 actgctgatc tgacagggtg atcttgtctc atctccagag gaagtgggga gtgggaggtc 24000 acaggcatca gagcaccaga gaggagctgc acagaggctc tgggagggcc atgggaatgt 24060 gagggctgaa gggatggtgc tgatggcatg gggactccct ctggagaggg tggcacagtg 24120 tggtggcagc aggaagagag gtgggatcca tgcccggggg aaggatagca gggactgcgg 24180 tggcccccct aaccagggtg ggagtagggt ggggtggggt taggaaacat tacttcccct 24240 tccacctctt atccccagag tctctcagac ctggacaggc ccagcaccca aatccgggct 24300 tagacagccc tcaggccctg cccatcttct ttgtcatcaa acgtagaccc atgattactg 24360 ggctccttgg ggcctgcaag ggtgtctgtg gggtgctgct gtctatccat gccctggggt 24420 gtctggactg tcatctccag aggacttctg gtccatcctg actcaaggcc actccatcca 24480 ggaaaaggct cttcttcagt cacttcccat ctccccagcc ttgcctctgc ttactggagt 24540 gttactctga gggttgtaga gagggacgga gtgaggggga agtgattgtt ggtggtcctg 24600 tttccaggaa accttgtcct ttccagggca aactgtacca ggatggcccg gaccctgcac 24660 tcatgggggt cacagccccg cctgggtacg gggcccttgc ggggatagaa cctggacaca 24720 gaaggcggcc ctggggaagg tgggccgagg tgagggaagc tgggagagcc tgtcccgggc 24780 aggaagcctc cagctcctct ctgggtaacc agctttgtgg aacagttaag atcacaggaa 24840 caggtggtgg gggtgggccc tgaggggaga gagaggctgc aaacctgtcc acagctgctt 24900 cccccagatg gtttctaggg cttcacactg gtcctcatgc ccaccagcca aatcttgctg 24960 aaagctgcct cacccgccct gcccagtgct cccgatgccc accttgtctc ttcccactct 25020 gtccccgtgc tgtgctctgg cccctgactt tcttcatgct gttccttcca cctcaaatgc 25080 ctctttcctc tcccctacca tccccatttc tcagccctca gggtcacatc tgggccgcct 25140 gcctcggaac aacctggaca gctccagggc tcctggcttt gtcctttccc ttgttctgcg 25200 ctctatgtgg gcccagcacc caggggttca gaggttcgca tgctgaccat ctgcctggga 25260 attgctcctg atgcaggcaa atgcacaggc atgcaaacct ctgaccccct gggcaccagc 25320 cttgcagcag cgctggggat gcagactcga gggccaggtc gactctgctc ttggggagct 25380 cccagtgtgg aggaggaagg cactgccctg ccttgaggaa gccctggctg gggtgtttct 25440 ccagaggagc ctccagttca gctgtgaaga gaagtataaa cagctactgc cagtggatgc 25500 gaagtcgtct gggatgctag tgcttctcgg gcactgcaga cagtaaacca tcaatggtgc 25560 ccagtttacc tcctttgtct gcacacatgc agctagctcc aggctcggtt atgggggcac 25620 caactagggg caccaactat gcccctgtct ctttgcagca ttcagagtcc tagtcactga 25680 cgattggagt gaggagtcat ttccttgcag gcaaggccag gccacagtta ccccatcccc 25740 tcccagtggg cagtggggag cctggcaggt gggctgtatg cctgggtggg ttgttgatgc 25800 tctgcccact tctcagggcc ggaaggagcc atactatatc acagagttgt tccaggccgc 25860 agacaagaac aaggacaacc agatctgctt cgatgagttc ctctacatct tgggcaagct 25920 ggtgaaggac taccacctgc actaccacca gcagctgtgt gcccgctact gtgcccaaca 25980 cagcctctac tagagggagc tcaggcagcc tcctgcccac cggtgccgga cccaggagga 26040 ggtgtgacct tgatatcagg agctgaatgg agaacacagc tgtgtgtgtc tgtgtgtgtc 26100 cctgtgtgtg tgtgcacatg tgtgtacatg tctgtggaaa ggacatcaat gtgagagaga 26160 ataaagcaat ttcatacata tttccaagga tttgtcagta tatggttctg ggcttcacct 26220 acaatccaga aaaagaagtt tcggtcccaa gctgggaaag atccatttta gatcaacgaa 26280 atagcccttg cctccaggga gcccctgtct gaggggaaga aacagcttct atctccaggg 26340 agcccctttt tgagggggag acacagctcc tatctccagg gagtccctgt ctgaggagga 26400 gacacagctt attcctctag ggagtttata ttggatggga gagacaccac ctctgattcc 26460 agggggccct atctgatagg gagacagtcc ccacccgcag tgttcagcct gagaaggaag 26520 agtctcctct cttggggaga tagcgaggcc tcgcttgtgg tcactcactc acccaccaca 26580 caggtggtag cacaggggtg agggtagggg tgaactaaca tgccgctccg acagcatccc 26640 tgctctgaaa gagagcccca agaatcagtg aacaagggtg gggctgagcc tgggaagaga 26700 ccaggatcgg gaggcaggtg catttctagc agagggaaca acagtagaaa atcataaagt 26760 atgtctagga gcaacagaaa ttttgcttgg aaattagtgt tcatggagaa aacagtagga 26820 agtcagcttg aatgggtggg ttaggaccag agtctggaag tccctgaaaa ctgagcattg 26880 gaatttggac tttatccttt tggtaaggga tccttagttg ttaagtgtgg ggaaggggcg 26940 agggccctgg gaccagctct gtgctttagg aaactagtgg taggggtttg gggtggagga 27000 agacagatca gacctgcaca gcctggctag aggctgtgac gaggaggtaa acagcttcat 27060 ggggacggaa gggagggagg cggcatcaga aaaggcagaa catcaaggtc cagacctggg 27120 cgcagactga gggagaggag gatccagaat gaggtggagg tttcaggtgc tggcgattgg 27180 catgggacct cggtgcctgg gtgggagcca gtctgcaggg aatattgtgt gctgggtttg 27240 cacatgctga gtcagacact gacaggagct gagccaacaa tccagcctgg cagaaccaca 27300 gacacatgtt aagggaagag caatgagtag aacctgggtg acagtcaacc caggaaggct 27360 tcctgaggga gagaagggtt gggtctgttt ttttctacaa catgatgatg gatgtgaggg 27420 ttactcctga cccagggcta ttcatgaacc actgatctga gtcctccggt atccctgacc 27480 ccacccacct gagacctgtc cctgcccttg ctctgtttct ttttcctttt cctctcccct 27540 gggactctag ggatctaatg cagaatccct tagggagggt ctcctctgcc ttcaggaaat 27600 gccagagccc actttagagg gttgtctttt ctgagggttg gtctgggaac cggtgtcctg 27660 agcttactga gatagaaatc atggattttg aaagagtgtt ggggggtgat ataccacctg 27720 cgcacaggac tgcagggtca cttaagaaac ttggtctggt tccctcccca cctggtcctt 27780 tgcgccaaac atggtggatt gtccctggag ctgagctgga gaccttgttt ctcatcagtc 27840 aggctctggg gcagaatttg cccctgctgc tccgggcctg gcctgctgtc cctcccacac 27900 ttgccatcag cttagtttgc ctttcaggac ctagctgggc cctccattcc ttgggagatg 27960 tctgcacccc attccccttt gcattctttc ctgtggaagg gcatcttctg ccacactgtg 28020 cttgttttgt actctccgcc gagacaggac ctcagtgtcc ccataaacgc tcagcaggtg 28080 tttggggaag gaatgcagaa ttggggcctg tggggctgga attgatgacc tagatctgtg 28140 ctccttcctg caggcccctg gctgtgtcta gaggcatgaa gaccatcgcc tgagttactt 28200 tggccactct tcttgcaggc ccaggggaga aatacctgtc tcacctgaga agtgctgggc 28260 tccacaggca ttgagtacga agcaggggca cccagcctga gccctccctg ccctctcctg 28320 cccccttctg ggggtttctt caccagctct gcctgctctg tcctcatttc cttggcctca 28380 gggatggacc tgtcaggtct gttgggacac acccagggac tgagcccttt cctgtaaaca 28440 tgaccaggtt ccgctccctc taggttgccc catgtccgct aggctgctta cagcctctgc 28500 ctttccccag atgtgcttac ccaagtcctg ataccttttg ctgcaaggtc agttcagcct 28560 ggctcctgct gtccccaaag cacccaaggc tgtccagggg cgcagtttct ggggaggggg 28620 cgacatttca cgatcttgct ggtcagcctg tacatgatgt gggaaggagg tcaccactca 28680 ggactccctc actggaccag gggaaggacc tgaagtaatg ccctgtgcct cagtttcccc 28740 atctgtcaaa tagggataat tatacttgta atgtccacat cactaggttg ctgggaatat 28800 caaatgagtc agtggatgca aaatactttg aaaatatgat atggtgcttt gaggcaggtg 28860 ctgttatgct ggtcacatag gatagtacgt ggtgaataat aggtattaac caagggtgga 28920 tccttggttg aaaacttgtc atgtcagaaa tggcgttgtt ttcctagatg gagcttgatt 28980 catcttttgt caaggaagtc agactgcatt tgtttgatga atttataccc tgccttcttc 29040 cagaaatgat ttaagatggc tgattgtgat aaagagaatt tctgccttgg ataagggaag 29100 ggtcaaactt aattttgtat tcatttatcc ctcaataagt attaattgaa catgtagtag 29160 ctgccaggcc ctagggttgt gaaaagaaat gtgatttctt ttctaaatgg tctcctggtc 29220 ccaaagaaaa gacagacaat aaacaagtga atcataacat agcagggcaa atgctgtgat 29280 gggtaaggat ttgggtagca tggaggagag aagaactaat tctgccttga tggggtgagg 29340 gcaggtggat cagggatgga cttggagcag atgatgcctg agctggatca ggaatggtga 29400 ggaggacatt acagggacaa aaggcattac aggcaggaat aggaagtgga tgctgtcaca 29460 tcacatcatg agtcactcaa tcatttgata cgctgaatta ctatgtctct ctgtggggct 29520 tagtttcctc atctgtacaa tgggcattat aatagtacat acgtcattgg attagtgtga 29580 gaattaaatg atcaatgcaa ataaagcagc acttagaata gttcccggac atgggaaaag 29640 ctcagtgagt gtgaactagt attttgtcat gatttgctct gatcagtgat tgtggctgct 29700 gttattgtgt gtgctgggca ctgtgctggg tccccaatgg ctcacatcca gagagagctg 29760 gatttatttt ggagggtgaa agactccctg ctatgtttat gcaatggctc atgcccttgt 29820 gcaatgcaga gggaccccaa gcagcctcca tctcccaggg cacggtggat ccccagcttc 29880 acagaacagg agagctgtgg aggagtgtgg gcagcagggt aggaatggat ttagccctcg 29940 gcaacaacac atgtccccac aaaacatttt cttcatccat tcatgtgttg agggacactt 30000 gggttgcttc caccttttgg ctcttgtaaa taatgctgct atgaacatga atgtacaaac 30060 atctgtttga atccctgcat tcaattcttt tgcatatata cccaggagca gaatgatgga 30120 tcatatggta attctgtgtt tatttatttg aggaacaaac ttgccgtttt ccataacagc 30180 tgcactattt tacattccca ctaacagtgc attaggcttc caattctcta tgccctcacc 30240 aacacttgtt ttctgggttt taaaagaagt agtagtcatc cttgtaggtg tcaggtggta 30300 tctcattgtc gttttgcttc atgttttcct aaagattagt aattttcata tgcttattga 30360 ccatttgtat atcttcttcg gagaagtgtc tatttgagtc ttttccccaa tttttgattg 30420 gtttgtttgt tttttgttgt tgagttgtag ggattctttt atattctgga tattaatccc 30480 ttatcagata tttgttttac aaatattttc tttgtaacaa cagaaacaca ccacagtctt 30540 caaggttgga agccagttaa tctgagtagc attttgttag tggtggggag aggatttgtt 30600 cctcctgaaa tcctggggaa ttggccacct cctcttctcc tcttaggcat gaagcgcgtc 30660 tggcttctcc aaagaactct tcccctccac tacctcagag ttagcttcct ctcttcagcc 30720 agtgatcctg gggtcccaga cacaataatt aaccaagaga gggtgaaagg ctccctgctg 30780 tgtttatgca atggctcagg cccttgtgaa gtgccgaggg accccaagca gcctccatct 30840 cccagggcat ggtccatccc cagcttcaca gaacaggaaa gctgtggagg agtgtgggca 30900 gcagggtagg aatggatata gcccttggca acaacacatt tccccacaaa gcacccaccc 30960 aaaagaacaa caacgatagt tttagttttt agtaatgaga acaatagttc tcatgactaa 31020 aagccatcag ccaggacacg tgttctcaac ccttttgcgg tctttggacc ctttgaaact 31080 ctgacagaag ccatggagga atgttctcac tgagtgcatg cactcaaaat gatgcattca 31140 acttcaattc agtttcaggg atgtatggcc tgaccaccaa tgcaggggat tagcaatcgc 31200 aatagtggag agggcatggg agtgggaatc tggctggatc aagcaagtgg atgccagcag 31260 cccagaaaaa gagcccccct acctgctttt tccttctggg cactattgcc cagcaaatgc 31320 cttcctcttt ccgcttctcc tacctcccca cccaaaattt tcattctgca cagtgattgc 31380 cacattcacc tggttgagaa accagagact gtagcaactc tggcagggag aagctgtctc 31440 tgatggcctg aagctgtggg cagctggcca agcctaaccg ctataaaaag gagctgcctc 31500 tcagccctgc atgtctcttg tcagctgtct ttcagaagac ctggtaagtg ggactgtctg 31560 ggttggcccc gcactttggg cttctcttgg ggagggtcag ggaagtggag cagccttcct 31620 gagagaggag agagaaagct cagggaggtc tggagcaaag atactcctgg aggtggggag 31680 tgaggcaggg ataaggaagg agagtatcct ccagcacctt ccagtgggta agggcacatt 31740 gtctcctagg ctggactttt cttgagcaga gggtggggtg gtaaggaaag tctacgggcc 31800 ccgtgtgtgt gcacatgtct ctgtgtgaat ggacccttcc ccttcccaca cgtgtatccc 31860 tatcatccca cccttcccac cagagccata gccatctgct ggtttggtta tttggagagt 31920 gcaggccagg acaaggccat cgcttggggc atgaatcctc tgcgtactgc cctggccaga 31980 tgcaaattcc ctgccatggg attccccaga aggttctgtt tttcaggtgg ggcaagtccg 32040 tgggcatcat gttgaccgag ctggagaaag ccttgaactc tatcatcgac gtctaccaca 32100 agtactccct gataaagggg aatttccatg ccgtctacag ggatgacctg aagaaattgc 32160 tagagaccga gtgtcctcag tatatcaggg tgaggagggg ctgggtgtgg cgggggctct 32220 ctgcctggtc ctggggctgc cctgggccag cggtcctccc tgccaccctt catagatggc 32280 tatgcctcgg ctctctctga gatctttaaa ctctggcttc ttcctcctca atcttgacag 32340 aaaaagggtg cagacgtctg gttcaaagag ttggatatca acactgatgg tgcagttaac 32400 ttccaggagt tcctcattct ggtgataaag atgggcgtgg cagcccacaa aaaaagccat 32460 gaagaaagcc acaaagagta gctgagttac tgggcccaga ggctgggccc ctggacatgt 32520 acctgcagaa taataaagtc atcaatacct ca 32552 <210> 9 <211> 20 <212> DNA <213> COCH Sense primer <400> 9 agaaagcaga tgtcctctgc 20 <210> 10 <211> 20 <212> DNA <213> COCH Anti-sense primer <400> 10 tccccctgag ttgctgatta 20 <210> 11 <211> 20 <212> DNA <213> S100A8 Sense primer <400> 11 catcgacgtc taccacaagt 20 <210> 12 <211> 20 <212> DNA <213> S100A8 Anti-sense primer <400> 12 gaatgaggaa ctcctggaag 20 <210> 13 <211> 21 <212> DNA <213> CELSR3 Sense primer <400> 13 ctccatgttg gtgactgtca c 21 <210> 14 <211> 20 <212> DNA <213> CELSR3 Anti-sense primer <400> 14 tcctgccaca tgttctcaag 20 <210> 15 <211> 20 <212> DNA <213> PFKFB4 Sense primer <400> 15 actgaacccc ctgaagaaga 20 <210> 16 <211> 20 <212> DNA <213> PFKFB4 Sense primer <400> 16 atgagagttg ggcagttggt 20 <210> 17 <211> 20 <212> DNA <213> HMOX1 Sense primer <400> 17 aactttcaga agggccaggt 20 <210> 18 <211> 20 <212> DNA <213> HMOX1 Anti-sense primer <400> 18 cttgttgcgc tcaatctcct 20 <210> 19 <211> 20 <212> DNA <213> MTAP Sense primer <400> 19 tccttgaggg aggagattca 20 <210> 20 <211> 20 <212> DNA <213> MTAP Anti-sense primer <400> 20 tcctctggca caagaatgac 20 <210> 21 <211> 20 <212> DNA <213> MGC17624 Sense primer <400> 21 gtcctgaacg acaagcacct 20 <210> 22 <211> 20 <212> DNA <213> MGC17624 Anti-sense primer <400> 22 aggcttctgg gtcgatttct 20 <210> 23 <211> 20 <212> DNA <213> KIF1A Sense primer <400> 23 aagaacaagg gcaaccttcg 20 <210> 24 <211> 20 <212> DNA <213> KIF1A Anti-sense primer <400> 24 ctccattcat gttggtggcc 20

Claims (13)

  1. 서열번호 1의 염기서열을 갖는 COCH (Coagulation factor C homolog) 유전자, 서열번호 2의 염기서열을 갖는 CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3) 유전자, 서열번호 3의 염기서열을 갖는 HMOX1 (Heme oxygenase 1) 유전자, 서열번호 4의 염기서열을 갖는 KIF1A (Kinesin family member 1A) 유전자, 서열번호 5의 염기서열을 갖는 MGC17624 (C16orf74, chromosome 16 open reading frame 74) 유전자, 서열번호 6의 염기서열을 갖는 MTAP (methylthioadenosine phosphorylase) 유전자, 서열번호 7의 염기서열을 갖는 PFKB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) 유전자 및 서열번호 8의 염기서열을 갖는 S100A8(S100 calcium binding protein A8) 유전자로 이루어진 비근육침윤성 방광암(non-muscle-invasive bladder cancer) 진단 마커용 조성물.
  2. 삭제
  3. 삭제
  4. 제1항에 있어서,
    상기 진단은 비근육침윤성 방광암의 진행(progression) 및 재발(recurrence)을 포함하는 것을 특징으로 하는 조성물.
  5. COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 및 S100A8 유전자의 발현 수준을 측정하는 물질을 포함하는 비근육침윤성 방광암 진단 및 예후 예측용 조성물.
  6. 제5항에 있어서,
    상기 유전자의 발현 수준을 측정하는 물질은 상기 유전자가 전사하는 mRNA 또는 상기 유전자가 암호화하는 단백질의 양을 측정하는 것을 특징으로 하는 조성물.
  7. COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 및 S100A8 유전자의 발현 수준을 측정하는 물질을 포함하는 비근육침윤성 방광암 진단 및 예후 예측용 키트.
  8. 제7항에 있어서,
    상기 물질은, 상기 유전자의 핵산서열, 이의 상보적인 핵산서열, 상기 핵산서열들의 단편, 또는 상기 핵산서열에 의해 코딩되는 단백질을 특이적으로 인식하는 항체, 항체 단편, 앱타머(aptamer), 아비머(avidity multimer) 또는 펩티도모방체(peptidomimetics)를 포함하는 것을 특징으로 하는 키트.
  9. 대상체로부터 얻은 시료로부터 COCH, CELSR3, HMOX1, KIF1A, MGC17624, MTAP, PFKB4 및 S100A8 유전자의 발현 수준을 측정하는 단계;
    상기 측정된 유전자들의 발현 수준을 이용하여 진행 위험도(progression risk score)를 계산하는 단계; 및
    상기 진행 위험도를 이용하여 대상체의 비근육침윤성 방광암 진행 정도를 확인하는 단계를 포함하는 비근육침윤성 방광암 진단 및 예후 예측을 위한 정보제공방법.
  10. 제9항에 있어서,
    상기 진행 위험도를 계산하는 단계는,
    상기 측정된 유전자들의 발현 수준을 대수적으로 변환하여 각각의 측정된 유전자에 대해 변환된 값을 생성하는 단계;
    상기 변환된 값에 각각의 유전자에 대한 상수를 곱하는 단계; 및
    상기 곱한 값들을 합하여 진행 위험도를 계산하는 단계를 포함하는 것을 특징으로 하는 방법.
  11. 제10항에 있어서,
    상기 상수는 Cox 회귀 분석을 통해 구한 COX 회귀계수(Cox coefficient)인 것을 특징으로 하는 방법.
  12. 삭제
  13. 삭제
KR1020160082434A 2016-06-30 2016-06-30 방광암의 진단 및 예후 예측용 바이오 마커 및 그의 용도 KR101818352B1 (ko)

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