CN102459645B - 作为前列腺癌标记的磷酸二酯酶9a - Google Patents

作为前列腺癌标记的磷酸二酯酶9a Download PDF

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CN102459645B
CN102459645B CN201080031288.9A CN201080031288A CN102459645B CN 102459645 B CN102459645 B CN 102459645B CN 201080031288 A CN201080031288 A CN 201080031288A CN 102459645 B CN102459645 B CN 102459645B
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pde9a
expression
prostate cancer
hormone
sample
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Chinese (zh)
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CN102459645A (zh
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R.霍夫曼
M.D.豪斯利
D.J.P.亨德森
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University of Glasgow
Koninklijke Philips NV
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University of Glasgow
Koninklijke Philips Electronics NV
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201080031288.9A 2009-05-12 2010-05-11 作为前列腺癌标记的磷酸二酯酶9a Active CN102459645B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09159957.1 2009-05-12
EP09159957 2009-05-12
PCT/IB2010/052069 WO2010131193A1 (en) 2009-05-12 2010-05-11 Phosphodiesterase 9a as prostate cancer marker

Publications (2)

Publication Number Publication Date
CN102459645A CN102459645A (zh) 2012-05-16
CN102459645B true CN102459645B (zh) 2023-05-30

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US (1) US9828604B2 (enExample)
EP (1) EP2430189B1 (enExample)
JP (1) JP5918694B2 (enExample)
KR (1) KR101695866B1 (enExample)
CN (1) CN102459645B (enExample)
BR (1) BRPI1007620A2 (enExample)
RU (1) RU2592668C2 (enExample)
WO (1) WO2010131193A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101675664B1 (ko) 2015-01-30 2016-11-11 경희대학교 산학협력단 전립선암 예방 또는 치료용 조성물
DK3303616T3 (da) 2015-05-29 2021-03-01 Koninklijke Philips Nv Fremgangsmåder til prognose af prostatakræft
KR20180085387A (ko) 2016-12-27 2018-07-27 경희대학교 산학협력단 Trail 저항성 암 예방 또는 치료용 조성물
CN107119124B (zh) * 2017-05-10 2021-05-11 清华大学 一种检测待测样本中目标miRNA的含量的方法
KR102080887B1 (ko) * 2017-11-07 2020-02-24 고려대학교 산학협력단 Gcc2 유전자 또는 단백질을 과발현하는 엑소좀 기반 폐암 진단 또는 예후 예측용 마커 조성물
CN114349857B (zh) * 2022-03-15 2022-05-24 诺赛联合(北京)生物医学科技有限公司 一种Treg细胞制备方法以及在自身免疫性疾病方面的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029873A1 (en) * 1997-12-09 1999-06-17 Incyte Pharmaceuticals, Inc. Cyclic gmp phosphodiesterase
WO2004053493A1 (en) * 2002-12-09 2004-06-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 9a4 (pde9a4)
WO2004053492A1 (en) * 2002-12-09 2004-06-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 9a3 (pde9a3)
WO2004053494A1 (en) * 2002-12-09 2004-06-24 Bayer Healthcare Ag DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 9a2 (PDE9a2)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090176722A9 (en) 2000-01-28 2009-07-09 Shiv Srivastava Androgen-regulated PMEPA1 gene and polypeptides
WO2004042389A2 (en) 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)
AU2003283427A1 (en) 2002-12-09 2004-06-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with phosphodiesterase 9a1 (pde9a1)
US7405237B2 (en) 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
AU2007324128B2 (en) 2006-10-10 2013-10-10 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029873A1 (en) * 1997-12-09 1999-06-17 Incyte Pharmaceuticals, Inc. Cyclic gmp phosphodiesterase
WO2004053493A1 (en) * 2002-12-09 2004-06-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 9a4 (pde9a4)
WO2004053492A1 (en) * 2002-12-09 2004-06-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 9a3 (pde9a3)
WO2004053494A1 (en) * 2002-12-09 2004-06-24 Bayer Healthcare Ag DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 9a2 (PDE9a2)

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JP5918694B2 (ja) 2016-05-18
EP2430189B1 (en) 2018-11-21
KR20120034650A (ko) 2012-04-12
EP2430189A1 (en) 2012-03-21
BRPI1007620A2 (pt) 2016-02-23
JP2012526543A (ja) 2012-11-01
US20120065100A1 (en) 2012-03-15
CN102459645A (zh) 2012-05-16
US9828604B2 (en) 2017-11-28
WO2010131193A8 (en) 2011-12-08
KR101695866B1 (ko) 2017-01-13
RU2592668C2 (ru) 2016-07-27
RU2011150291A (ru) 2013-06-20
WO2010131193A1 (en) 2010-11-18

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