CN108026587A - 用于治疗癌症的新颖生物标记和方法 - Google Patents

用于治疗癌症的新颖生物标记和方法 Download PDF

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CN108026587A
CN108026587A CN201680051358.4A CN201680051358A CN108026587A CN 108026587 A CN108026587 A CN 108026587A CN 201680051358 A CN201680051358 A CN 201680051358A CN 108026587 A CN108026587 A CN 108026587A
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cancer
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A.A.巴尔德拉斯
F.H.克鲁扎列圭
K.赫德森
R.K.麦克尤恩
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Abstract

描述了用于治疗与PI3K通路相关联的病理状况例如癌症的生物标记，以及使用PI3K通路的上游组分的抑制剂例如PI3K‑α抑制剂或AKT抑制剂的方法。具体而言，描述了在癌症治疗中用于患者选择的生物标记，以及治疗处理方法、诊断试剂盒和检测方法，其中具有PI3K通路的上游组分(例如PIK3CA基因和/或AKT基因)的突变、以及野生型MAP3K1基因和MAP2K4基因的癌症会更可能有利地响应于用PI3K通路的上游组分的抑制剂进行的治疗。

Description

用于治疗癌症的新颖生物标记和方法
优先权要求
本申请要求保护2015年9月17日提交的美国临时申请号62/219,698的权益，将该文献通过引用以其全文结合。
背景技术
乳腺癌是世界上最普遍的癌症之一，每年诊断出超过1,300,000个病例并且每年死亡超过450,000例。治疗乳腺癌最大的挑战之一是它的异质性。大规模DNA测序的出现提供了乳腺癌的突变景观，并且这种大规模DNA测序与拷贝数变异和基因表达数据的组合已经导致将乳腺癌分为十个综合簇(Curtis C等人，Nature[自然]，2012，486，346-352和Dawson S-J等人，EMBO J[欧洲分子生物学学会杂志]，2013，32，617-628)。已知PI3K/AKT/mTOR信号传导通路是癌细胞增殖、存活、代谢和凋亡的关键介导者(Fruman和Rommel，Nature Reviews[自然综述]2014，13:140-156)，以及对10个综合簇的分析已经显示磷酸肌醇-3-激酶、催化性α多肽(PIK3CA)，编码PI3K的α同种型(PI3Kα)的基因在几个雌激素受体阳性(ER+)簇中频繁突变。总的说来，PIK3CA在45％的管腔A型乳腺癌病例中发生突变(癌症基因组阿特拉斯网络(Cancer Genome Atlas Network)，Nature[自然]，2012，490，61-70)。这些研究连同涉及该PIK3CA基因在肿瘤发生中的多种其他研究(概述于WO 2014/114928中)已经导致相当大的研究努力以发现用于治疗癌症的PI3K-α抑制剂。然而，癌症患者的反应率通常很低，并且迄今为止靶向PI3K-α抑制的抗癌剂尚未被批准。
作为PI3K的主要效应物，AKT由于生长因子受体信号传导而常常被发现于乳腺癌中。AKT通过由PI3K活性产生的磷脂PIP3和PIP2激活。膜结合的PDK1通过PIP3直接激活并且磷酸化位于激活环上的Thr308上的AKT。例如，在HER2-阳性乳腺癌中，PI3K通路被激活导致AKT的高活性，如通过Thr308和Thr473的磷酸化(由MTORC2介导)所测量的。在ER+乳腺癌中，激活型PIK3CA突变是普遍存在的，并且这超过了激活生长因子以维持高水平PIP3和PIP2的需求，因此，通路活性通过AKT介导。虽然不是所有的PI3K激活的信号传导效应都归因于AKT信号传导，但是这种激酶仍然是在该通路中的主要节点，并且一直是药物发现和开发中的巨大努力的焦点。AKT同种型AKT1、AKT2和AKT3的抑制剂已经被开发并且目前正在乳腺癌的临床试验中。已经在ER+管腔型乳腺癌中鉴定了AKT1的激活型突变。在超过80％的突变病例中，受影响密码子是Glu17，其频繁突变为赖氨酸(E17K突变)。在ER+管腔型乳腺癌中，此突变的发生率约为3％。认为这种或其他的激活型突变会赋予AKT抑制剂敏感性，并且该假说目前正在临床中进行测试。
最近乳腺癌患者的基因组研究也已经开始揭示丝裂原活化蛋白激酶(MAPK)在癌症中促进细胞存活或凋亡的可能作用，特别是通过在MAP3K1和MAP2K4(JNK细胞死亡通路的两个上游MAPK)中的失活型突变(Pham T等人，Genes&Cancer[基因和癌症]，2013，4，419-426)。在管腔A型乳腺癌中发现MAP3K1(13％-20％)和MAP2K4(约8％)中的突变，并且在11.56％的PIK3CA突变体中的临床样品中已经报道了PIK3CA和MAP3K1的同时突变(癌症基因组阿特拉斯网络(Cancer Genome Atlas Network)，Nature[自然]，2012，490，61-70和Ellis M等人，2012，Nature[自然]，486，353-360)。
该PIK3CA和MAP3K1/MAP2K4基因的同时突变作用于促进患者对PI3K通路的上游组分的抑制剂的反应(如果发生的话)的机制仍然是未知的。此外，对于该AKT和MAP3K1/MAP2K4基因的同时突变在此类患者的反应中的作用(如果有的话)了解甚少。因此，仍然需要了解PI3K通路(例如PIK3CA和AKT基因)的上游组分的基因突变与MAP3K1/MAP2K4基因突变之间的相互作用及其在肿瘤发生中的作用，以及任何这种相互作用在使用PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的患者治疗中的相关性。
发明内容这篇说明书描述了用于治疗与PI3K通路相关的病理状况(例如癌症)的生物标记，以及使用PI3K通路的上游组分的一种或多种抑制剂(例如PI3K抑制剂(例如PI3K-α抑制剂)或AKT抑制剂)的方法。具体而言，该说明书提供了在癌症治疗中用于患者选择的生物标记，以及治疗处理的方法、诊断试剂盒和检测方法。
本文描述了鉴定和表征编码PI3K通路的上游组分的基因(例如该PIK3CA基因或AKT基因)的状态、编码MAP3K1或MAP2K4的基因的状态与用PI3K通路的上游组分的抑制剂治疗的易感性之间的关系。因此，这提供了用于选择患者(尤其是癌症患者)用PI3K通路的上游组分的抑制剂进行治疗和/或避免更不可能与该治疗发生治疗反应的患者治疗而由此避免不必要的治疗以及可能与该无效治疗有关的任何副作用的机会、方法以及工具。
本说明书部分涉及患者选择工具和方法(包括个人化药物)。该选择是基于要处理的癌细胞是否具有PI3K通路的野生型或突变型上游组分(例如野生型或突变型PIK3CA基因或野生型或突变型AKT基因)以及野生型或突变型MAP3K1或MAP2K4基因。因此，PI3K通路的上游组分(例如PIK3CA或AKT)的基因状态和MAP3K1或MAP2K4基因状态可以用作对用PI3K通路的上游组分的抑制剂治疗具有易感性的生物标记。具体而言，该说明书描述了突变阳性PIK3CA基因或AKT基因和突变阳性MAP3K1或MAP2K4基因与作为结果的对用PI3K通路的上游组分的一种或多种抑制剂(例如PI3K-α抑制剂或AKT抑制剂)治疗的敏感性的降低之间的联系。可替代地，该说明书描述了突变阳性PIK3CA基因或AKT基因和野生型MAP3K1和MAP2K4基因与作为结果的对用PI3K通路的上游组分的一种或多种抑制剂(例如PI3K-α抑制剂或AKT抑制剂)治疗的敏感性的增加之间的联系。
在一个方面中，描述了一种治疗患有癌症的患者的方法，该方法包括：(a)在代表该癌症且先前从该患者分离的样品中，确定PI3K通路的上游组分的基因状态是野生型还是突变型；(b)确定该样品中的MAP3K1基因是野生型还是突变型；(c)确定该样品中的MAP2K4基因是野生型还是突变型；并且(d)向该患者给予有效量的PI3K通路的上游组分的抑制剂，如果：(i)PI3K通路的上游组分的基因状态被确定为是突变型；(ii)该MAP3K1基因被确定为是野生型；并且(iii)该MAP2K4基因被确定为是野生型。
在另一方面，描述了一种治疗患有癌症的患者的方法，该方法包括：(a)确定该患者的癌细胞中的AKT基因是野生型还是突变型；(b)确定该患者的癌细胞中的MAP3K1基因是野生型还是突变型；(c)确定该患者的癌细胞中的MAP2K4基因是野生型还是突变型；(d)向该患者给予有效量的AKT抑制剂，如果这些癌细胞具有：(i)突变型AKT基因；(ii)野生型MAP3K1基因；和(iii)野生型MAP2K4基因。
在另一方面，描述了PI3K通路的上游组分的抑制剂用于治疗癌症的用途，其中这些癌细胞具有在PI3K通路的上游组分中的突变、野生型MAP3K1基因和野生型MAP2K4基因。
在另一方面，描述了一种用于取消选择患有癌症的患者进行治疗的方法，该方法包括：鉴定患有对用PI3K通路的上游组分的抑制剂的治疗具有潜在易感性的癌症的候选患者；并且确定先前从该候选患者分离的代表该癌症的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；其中，如果这些癌细胞具有突变型MAP3K1或MAP2K4基因，则取消选择该患者用PI3K通路的上游组分的抑制剂进行治疗。
在另一方面，描述了一种治疗患者体内的癌症的方法，该患者的PI3K通路的上游组分以及MAP3K1和MAP2K4的癌细胞基因状态已经被确定，该方法包括：如果这些癌细胞具有在PI3K通路的上游组分中的突变、野生型MAP3K1基因和野生型MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂。
明确需要将针对以下患者富集或用于选择这些患者的生物标记：这些患者的癌症将对用PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的治疗起反应。鉴定不太可能对试剂反应的患者的患者选择生物标记在癌症的治疗中也很重要，因为这些患者选择生物标记会减少对此类试剂的潜在副作用无反应的癌症的患者的不必要治疗，并且允许选择最有可能受益于治疗效果的患者进行治疗。
附图说明
图1示出了乳腺癌细胞系中PIK3CA、MAP3K1和MAP2K4基因的突变状态。
图2A示出了在PIK3CA突变型乳腺癌细胞系中，在siRNA靶向MAP3K1mRNA之后基础pAKT(T308)水平的诱导。图2B示出了当与亲本(P.)MCF7细胞比较时，在突变细胞系(CR1.4和CR2.5)中，在MAP3K1基因破坏后基础pAKT(T308)水平的以及对化合物A(PI3Kα和PI3Kδ抑制剂)处理的部分抗性的诱导。
图3示出了在亲本MCF7细胞(左图)和MAK3K1-缺陷型MCF7CR2.5细胞(右图)中使用递增水平的化合物A化合物B(AKT抑制剂)和GDC-0068(AKT抑制剂)的治疗对MAP3K1、pJNK、pPRAS40、pS6RP(S235/236)和粘着斑蛋白的影响。
图4示出了在用500nM化合物A和化合物B治疗以后的亲本MCF10A-H1047R(A)、MCF7(C)和MAP3K1突变型MCF10A-H1047R CR2.3(B)和MCF7CR1.4细胞的增殖时间历程。
图5示出了在使用化合物A、化合物B和mTOR抑制剂(AZD2014)的情况下，亲本细胞系与MAP3K1-缺陷型细胞系的增殖的IC50的比较。
图6示出了在使用500nM化合物A、化合物B和DMSO治疗60和66个小时之后亲本细胞系与MAP3K1-缺陷型细胞系的汇合百分比。
图7A示出了MAP3K1在体积上的耗减(左图)和在3D-基质胶腺泡结构上的细胞凋亡(右图)的影响。MCF7亲本(灰色)和MCF7CR2.5(黑色)腺泡和MCF10A-H1047R亲本(灰色)和MCF10A-H1047R CR2.9(黑色)腺泡使用DMSO(-)或化合物B(+)处理15天。图7B示出了在2μM化合物B不存在(灰色)或存在(黑色)的情况下，MCF7亲本与MCF7CR2.5腺泡的外层细胞的pS6强度均值的量化。
图8示出了MCF7亲本与MCF7CR2.5异种移植移植物在两个时间点(25天和45天)的肿瘤体积。
具体实施方式
生物标记可以描述为“作为正常生物过程、致病过程或对治疗性干预的药理学响应的指示剂客观地经测量且评估的特性”。生物标记为与一种特定病状或疾病有关的任何可鉴别且可测量的指示剂，其中在生物标记的存在或含量与该病状或疾病的一些方面(包括该病状或疾病的存在、它的含量或变化含量、它的类型、它的阶段、它的易感性或对用于治疗该病状或疾病的药物的反应)之间存在相关性。相关性可以为定性的、定量的或定性且定量的。典型地，生物标记为化合物、化合物片段或化合物组。这些化合物可以为在生物体中发现或通过生物体产生的任何化合物，包括蛋白质(和肽)、核酸以及其他化合物。
生物标记可以具有预测能力，并且因此可以用于预测或检测特定病状或疾病的存在、含量、类型或阶段(包括特定微生物或毒素的存在或含量)、对特定病状或疾病的易感性(包括遗传易感性)或对特定治疗(包括药物治疗)的响应。据认为在药物发现和发展的未来，生物标记将通过改良研究与发展程序的效率而发挥日益重要的作用。生物标记可以用作诊断剂、疾病进展监测剂、治疗监测剂以及临床结果预测剂。举例来说，不同生物标记研究项目试图鉴别出特定癌症和特定心血管疾病以及免疫疾病的标记。据相信新的经验证的生物标记的发展将使医疗和药物发展成本显著降低，并且使多种疾病和病状的治疗显著改善。
为了最佳设计临床试验并且为了从这些试验获得最多信息，生物标记可以为需要的。标记在替代品和癌细胞或其中可检测到标记的其他患者样品中可以是可测量的。这些标记理想地也将与功效相关并且由此可以最终用于患者选择。
因此，本发明的这一方面的根本技术问题为鉴别对用PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的治疗的患者分类的方法。该技术问题通过提供在此的权利要求书和/或说明书中所表征的方面来解决。
如本文实例详述的，发现具有MAP3K1或MAP2K4基因突变的细胞通常对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的生长抑制不太敏感。生长抑制会由于细胞增殖的抑制和/或增加的细胞死亡而发生。
该说明书提供了确定细胞对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的敏感性的方法。这些方法包括确定PI3K通路的上游组分的基因(例如PI3K-α基因或AKT基因)的状态以及在所述细胞中MAP3K1和MAP2K4基因的状态。如果这些细胞具有在上游组分上的突变(例如突变的PIK3CA基因或AKT基因)并且这些细胞具有突变的MAP3K1或MAP2K4基因，那么这些细胞被鉴定可能对PI3K通路的上游组分的抑制剂不敏感。因此，那些具有在上游组分(例如PIK3CA基因或AKT基因)中的突变和突变的MAP3K1或MAP2K4基因的患者被预测对PI3K通路的上游组分的抑制剂(例如PI3K-α抑制剂或AKT抑制剂)的治疗特别不敏感。如果这些细胞具有在上游组分中的突变(例如突变的PIK3CA基因或AKT基因)并且这些细胞具有野生型MAP3K1和MAP2K4基因，那么这些细胞被鉴定可能对PI3K通路的上游组分的抑制剂敏感。因此，那些具有在PI3K通路的上游组分(例如PIK3CA基因或AKT基因)中的突变以及野生型MAP3K1和MAP2K4基因的患者被预测对PI3K通路的上游组分的抑制剂(例如PI3K-α抑制剂或AKT抑制剂)的治疗特别敏感。
具有突变的PIK3CA基因和野生型MAP3K1和MAP2K4基因的患者被预测对PI3K-α抑制剂或AKT抑制剂的治疗敏感。具有突变的AKT基因和野生型MAP3K1和MAP2K4基因的患者被预测对AKT抑制剂的治疗敏感。
如果在细胞生长测定中一种或多种抑制剂抑制细胞或细胞群数目的增加(通过抑制细胞增殖和/或通过增加细胞死亡)，那么该细胞或细胞群对PI3K通路的上游组分的一种或多种抑制剂敏感。此处描述的方法可用于预测哪些细胞或细胞群通过生长抑制更有可能对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂敏感。
在某种程度上，本披露进一步基于可用于确定患者对PI3K通路的上游组分的抑制剂的可能响应性的方法，包括确定是否给予PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂。具体地，本发明的方法包括确定患者的一个或多个癌细胞中PI3K通路的上游组分(例如PIK3CA基因或AKT基因)以及MAP3K1和MAP2K4基因的基因状态(例如野生型或突变型)。上游组分(例如突变型PIK3CA基因或AKT基因)的突变和突变的MAP3K1或MAP2K4基因的存在指示当癌细胞与PI3K通路的上游组分的一种或多种抑制剂接触时不太可能通过生长抑制来响应。因此，上游组分(例如PIK3CA基因或AKT基因)以及MAP3K1和MAP2K4基因的基因状态(在癌细胞中)可用于选择患者使用所述上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗。
此外，披露了一种用于鉴定一名或多名患者可能对PI3K通路的上游组分的一种或多种抑制剂敏感的体外方法。还披露了能够检测PIK3CA、AKT、MAP3K1和MAP2K4基因的突变状态的寡核苷酸或多核苷酸引物或探针的用途。还披露了用于检测PIK3CA、AKT、MAP3K1和MAP2K4突变的试剂盒的用途。
还披露了用于确定患有癌症的患者对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的药物治疗是否有可能反应的体外方法，所述方法包括以下步骤：(i)获得先前从所述患者收集的代表该癌症的样品；(ii)确定在所述样品中PI3K通路的上游组分(例如PIK3CA基因或AKT基因)是否包含突变；并且(iii)确定在所述样品中MAP3K1或MAP2K4基因是否包含突变。MAP3K1或MAP2K4基因突变的不存在指示对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的治疗具有增加的反应可能性。作为基因生物标记测试，包含野生型MAP3K1和MAP2K4基因的癌症鉴定将富集对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的反应。包含野生型MAP3K1和MAP2K4基因的个体癌症对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂具有更大的反应可能性。
第二种这样的方法包括以下步骤：(i)获得先前从所述患者收集的代表该癌症的样品；(ii)确定在所述样品中该PIK3CA基因是否包含突变；并且(iii)确定在所述样品中MAP3K1或MAP2K4基因是否包含突变。PIK3CA基因的突变以及MAP3K1或MAP2K4基因突变的不存在指示对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的治疗具有增加的反应可能性。作为基因生物标记测试，包含突变型PIK3CA基因和野生型MAP3K1和MAP2K4基因的癌症鉴定将富集对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的反应。包含突变型PIK3CA基因和野生型MAP3K1和MAP2K4基因的个体癌症对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂具有最大的反应可能性。
另一种这样的方法包括以下步骤：(i)获得先前从所述患者收集的代表该癌症的样品；(ii)确定在所述样品中该AKT基因是否包含突变；并且(iii)确定在所述样品中MAP3K1或MAP2K4基因是否包含突变。AKT基因突变以及MAP3K1或MAP2K4基因突变的不存在指示对该AKT抑制剂的治疗具有增加的反应可能性。作为基因生物标记测试，包含突变型AKT基因和野生型MAP3K1和MAP2K4基因的癌症鉴定将富集对该AKT抑制剂的反应。包含突变型AKT基因和野生型MAP3K1和MAP2K4基因的个体癌症对该AKT抑制剂具有最大的反应可能性。
“代表癌症”的样品可以是所分离(例如来自活检或来自血液中发现的细胞)的包含真实癌细胞的样品，或可以是已经进一步加工的样品，例如来自包含癌细胞的样品的PCR扩增核酸的样品，或者可以是癌症衍生的核酸(例如在患者的血液或其他体液中发现的循环游离DNA)的样品。
定义：
“AKT抑制剂”是指能够抑制任何AKT同种型的任何化合物或物质，也称为蛋白激酶B。AKT抑制剂的实例包括MK-2206、ipatasertib(GDC-0068)、afuresertib(GSK-2110183)、4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基-丙基]-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺、以及在WO 2006/046023、WO 2006/046024和WO 2009/047563中描述的那些。
“等位基因”是指遗传基因座的特定形式，通过它的特定核苷酸或氨基酸序列与其他形式相区分。
“扩增反应”为导致靶核酸优于非靶核酸进行特异性扩增的核酸反应。聚合酶链反应(PCR)为熟知扩增反应。
“癌症”在此用于指由于细胞转化成赘生性表型所出现的赘生性生长。该细胞转化通常涉及遗传突变。
“基因”为包含关于RNA产物的经调节生物合成的所有信息的DNA区段，包括启动子、外显子、内含子以及可以位于控制表达的5'或3'侧接区域内(不在该基因的转录部分内)的其他序列元件。
“基因状态”是指该基因为野生型或者不是(即突变型)。
“标记”是指能够产生指示在分析样品中存在靶多核苷酸的可检测信号的组合物。适合标记包括放射性同位素、核苷酸发色团、酶、底物、荧光分子、化学发光部分、磁性粒子、生物发光部分等。因此，标记为通过光谱、光化学、生物化学、免疫化学、电学、光学或化学手段可检测的任何组合物。
“非同义变异”是指基因编码序列中或与基因编码序列重叠的变异(变化)，导致产生不同(经改变的)多肽序列。这些变异可能影响或可能不影响蛋白质功能并且包括错义变异体(导致一个氨基酸取代另一个)、无义变异体(由于产生过早终止密码子而产生截短多肽)以及插入/缺失变异体。
“同义变异”是指不影响所编码多肽的序列的基因编码序列中的变异(变化)。这些变异可以间接地(例如通过改变基因表达)影响蛋白质功能，但在不存在相反证据的情况下，总体上假定为无害的。
“核酸”是指单链或双链DNA和RNA分子，包括自然界中所发现的天然核酸和/或经修饰的具有经修饰的主链或碱基的人工核酸，如本领域中已知。
“PI3K抑制剂”是指能够抑制磷酸肌醇-3-激酶的任何一种同种型(例如PIK3CA、PIK3CB、PIK3CD和PIK3CG基因的基因产物)的任何化合物或物质。PI3K抑制剂包括PI3K-α、PI3K-β和PI3K-δ抑制剂。PI3K-β和PI3K-δ抑制剂的实例是(R)-8-(1-(3,5-二氟苯基氨基)乙基)-N,N-二甲基-2-吗啉代-4-氧代-4H-色烯-6-甲酰胺和idelalisib。
“PI3K-α抑制剂”是指能够抑制磷酸肌醇-3-激酶的α-同种型的任何化合物或物质。PI3K-α抑制剂的实例包括BYL719、GDC0032、1-(4-(5-(5-氨基-6-(5-叔丁基-1,3,4-噁二唑-2-基)吡嗪-2-基)-1-乙基-1H-1,2,4-三唑-3-基)哌啶-1-基)-3-羟基丙-1-酮和在WO2009/080705、WO 2010/029082、WO 2011/000905和WO 2014/114928中描述的那些。
“引物”是指能够充当用于合成与待复制的核酸链互补的引物延伸产物的起始点的单链DNA寡核苷酸序列。引物的长度和序列必须使其能够引发延伸产物的合成。典型引物在与靶序列实质上互补的序列长度中包含至少约7个核苷酸，但略微更长的引物为优选的。通常，引物包含约15-26个核苷酸，但也可以采用更长或更短引物。
“多态位点”为基因座内导致在一个群体中发现至少两种替代性序列的位置。
“多态现象”是指在个体中在多态位点处所观察到的序列变异。多态现象包括核苷酸取代、插入、缺失以及微卫星，并且可以(但无需)引起基因表达或蛋白质功能方面可检测的差异。在不存在对表达或蛋白质功能的影响证据的情况下，包括非同义变异体的常见多态现象总体上视为包括在野生型基因序列的定义中。人类多态现象和相关注释的目录包括验证、观察的频率以及疾病关联，由NCBI(dbSNP:http://www.ncbi.nlm.nih.gov/ projects/SNP/)维护。请注意，当用于基因序列的情形中时的术语“多态现象(polymorphism)”不应与当用于化合物的固态形式(即化合物的结晶或非晶性质)的情形中的术语“多晶型现象(polymorphism)”混淆。本领域普通技术人员将通过其背景了解所需的含义。
“探针”是指具有与待检测的等位基因的靶序列完全互补的序列的单链序列特异性寡核苷酸。
“响应”是通过根据实体肿瘤反应评估准则(Response Evaluation Criteria inSolid Tumours；RECIST)进行的测量来定义，涉及将患者主要分成两个组：显示部分响应或稳定疾病的组和显示进行性疾病的迹象的组。
“存活”涵盖患者的整体存活和无进展存活。“整体存活(OS)”定义为从给药开始到由于任何原因死亡的时间。“无进展存活(PFS)”定义为从给药开始到第一次出现进行性疾病或由于任何原因死亡的时间。
“PI3K通路的上游组分”是指在mTOR的上游(并且不包括mTOR)的PI3K通路的基因组分。PI3K通路的上游组分包括PI3K同种型(包括PIK3CA、PIK3CB、PIK3CD和PIK3CG基因)、AKT同种型(包括AKT1、AKT2和AKT3基因)、PTEN、PDK1、SGK、INPP4B、INPP5D、PIK3R1和PIK3R2，并且特别是PIK3CA和AKT(例如AKT1和AKT2)。PI3K通路的上游组分的抑制剂包括PI3K抑制剂(例如PI3K-α、PI3K-β和PI3K-δ抑制剂，例如PI3K-α抑制剂)和AKT抑制剂。
用于治疗的选择的方法
根据一个方面，本文提供了一种用于选择治疗以用于患有癌症的患者的方法，该方法包括：提供来自患者的代表癌症的样品；确定在该患者的代表癌症的样品中PI3K通路的上游组分的基因状态是野生型还是突变型；确定该患者的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来选择患者用PI3K通路的上游组分的抑制剂进行治疗。
根据另一个方面，本文提供了一种用于选择治疗以用于患有癌症的患者的方法，该方法包括：提供来自患者的代表癌症的样品；确定在该患者的代表癌症的样品中PIK3CA基因或AKT基因是野生型还是突变型；确定该患者的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来选择患者用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗。
该方法可以包括或不包括实际患者样品分离步骤。因此，根据一个方面，提供了一种用于选择治疗以用于患有癌症的患者的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定PI3K通路的上游组分的基因状态是野生型还是突变型；确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来选择患者用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗。
在另一个方面中，提供了一种用于选择治疗以用于患有癌症的患者的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定PIK3CA基因或AKT基因是野生型还是突变型；确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来选择患者用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗。
在一个方面中，该方法包括确定PIK3CA基因的状态。
在另一个方面中，如果癌细胞DNA具有突变型PIK3CA基因和野生型MAP3K1和MAP2K4基因，那么该患者被选择用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗。
在另一个方面中，该方法包括确定AKT基因的状态。
在另一个方面中，如果癌细胞DNA具有突变型AKT基因和野生型MAP3K1和MAP2K4基因，那么该患者被选择用PI3K通路的上游组分的抑制剂例如AKT抑制剂进行治疗。
在另一个方面，如果癌细胞DNA具有突变型PIK3CA基因或突变型AKT基因以及突变型MAP3K1基因或突变型MAP2K4基因，那么患者不被选择用PI3K通路的上游组分的抑制剂进行治疗。
根据另一个方面，提供了一种用于选择患者用PI3K-α抑制剂进行治疗的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定PIK3CA基因是野生型还是突变型；确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来选择患者用PI3K-α抑制剂进行治疗。
根据另一个方面，提供了一种选择患者用AKT抑制剂进行治疗的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定PIK3CA基因是野生型还是突变型；确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来选择患者用AKT抑制剂进行治疗。
根据另一个方面，提供了一种选择患者用AKT抑制剂进行治疗的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定AKT基因是野生型还是突变型；确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来选择患者用AKT抑制剂进行治疗。
根据另一个方面，提供了一种选择患者用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定该PIK3CA基因或AKT基因是野生型还是突变型；确定先前从该患者分离的样品中的MAP3K1基因是野生型还是突变型；并且基于以上来选择患者用抑制剂进行治疗。
在一个方面中，如果癌细胞DNA具有突变型PIK3CA基因或突变型AKT基因、和野生型MAP3K1基因，那么该患者被选择用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗。在其他方面，如果癌细胞DNA具有突变型PIK3CA基因或突变型AKT基因、和突变型MAP3K1基因，那么不被选择用PI3K-α抑制剂进行治疗。
在另一个方面中，提供了一种选择患者用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定该PIK3CA基因或AKT基因是野生型还是突变型；确定先前从该患者分离的样品中的MAP2K4是野生型还是突变型；并且基于以上来选择患者用抑制剂进行治疗。
在一个方面中，如果癌细胞DNA具有突变型PIK3CA基因或突变型AKT基因、和野生型MAP2K4基因，那么该患者被选择用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗。在其他方面中，如果癌细胞DNA具有突变型PIK3CA基因或突变型AKT基因、和突变型MAP2K4基因，那么患者不被选择用PI3K-α抑制剂进行治疗。
根据另一个方面，提供了一种预测患者对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的反应性的方法，该方法包括：在该患者癌细胞中，确定该PIK3CA基因或AKT基因是野生型还是突变型；确定该患者的癌细胞中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来预测患者对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的反应性。
根据另一个方面，提供了一种在受癌症影响的人类患者中，确定PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的有效性的可能性的方法，该方法包括：在该患者癌细胞中，确定该PIK3CA基因或AKT基因是野生型还是突变型；确定该患者的癌细胞中的MAP3K1和MAP2K4基因是野生型还是突变型；并且基于以上来预测患者对PI3K通路的上游组分的一种或多种抑制剂例如PI3K-α抑制剂或AKT抑制剂的反应性。
根据另一个方面，提供了一种用于取消选择患者用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗的方法，该方法包括：确定包含癌细胞的先前从该患者分离的样品中的MAP3K1基因和MAP2K4基因是野生型还是突变型，并且其中，如果癌细胞DNA具有突变型MAP3K1基因或突变型MAP2K4基因，则该患者不被选择用该抑制剂进行治疗。
治疗方法
根据另一方面，提供了一种治疗患者体内的癌症的方法，该患者的PI3K通路的上游组分以及MAP3K1和MAP2K4的癌细胞基因状态已经被确定，该方法包括：如果这些癌细胞具有PI3K通路的上游组分的突变基因、以及野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂。
根据另一方面，提供了一种治疗患者体内的癌症的方法，该患者的癌细胞的PIK3CA或AKT基因状态以及MAP3K1和MAP2K4基因状态已经被确定，该方法包括：如果这些癌细胞具有突变型PIK3CA基因或突变型AKT基因、以及野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂，例如PI3K-α抑制剂或AKT抑制剂。
在另一个方面中，提供了一种治疗患者体内的癌症的方法，该患者的癌细胞的PIK3CA、MAP3K1和MAP2K4的基因状态已经被确定，该方法包括：如果这些癌细胞具有突变型PIK3CA基因、以及野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂，例如PI3K-α抑制剂或AKT抑制剂。
在另一个方面中，本文明提供了一种治疗患者体内的癌症的方法，该患者的癌细胞的AKT、MAP3K1和MAP2K4的基因状态已经被确定，该方法包括：如果这些癌细胞具有突变型AKT基因、以及野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂例如AKT抑制剂。
在另一方面中，提供了一种治疗患有癌症的患者的方法，该方法包括：在该患者的癌细胞中，确定PIK3CA基因或AKT基因的突变型或野生型状态；在该患者的癌细胞中，确定MAP3K1和MAP2K4基因的突变型或野生型状态；并且，如果这些癌细胞具有突变型PIK3CA基因或突变型AKT基因、和野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂。
根据另外的一方面，提供了一种治疗患有癌症的患者的方法，该方法包括：提供来自患者的代表癌症的样品；确定在该患者的癌细胞中PI3K通路的上游组分的基因状态是野生型还是突变型；确定该患者的癌细胞中的MAP3K1和MAP2K4基因是野生型还是突变型；并且，如果这些癌细胞具有在PI3K通路的上游组分中的突变、以及野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂。
根据另外的一方面，提供了一种治疗患有癌症的患者的方法，该方法包括：提供来自患者的代表癌症的样品；确定该患者的癌细胞中的PIK3CA基因或AKT基因是野生型还是突变型；确定该患者的癌细胞中的MAP3K1和MAP2K4基因是野生型还是突变型；并且，如果这些癌细胞具有突变型PIK3CA基因或突变型AKT基因、和野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂。
在另外的一方面中，提供了一种治疗患有癌症的患者的方法，该方法包括：提供来自患者的代表癌症的样品；确定该患者的癌细胞中的PIK3CA基因是野生型还是突变型；确定该患者的癌细胞中的MAP3K1和MAP2K4基因是野生型还是突变型；并且，如果这些癌细胞具有突变型PIK3CA基因、和野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂。
在另外的一方面中，提供了一种治疗患有癌症的患者的方法，该方法包括：提供包含来自患者的样品的癌细胞；确定该患者的癌细胞中的AKT基因是野生型还是突变型；确定该患者的癌细胞中的MAP3K1和MAP2K4基因是野生型还是突变型；并且，如果这些癌细胞具有突变型AKT基因、和野生型MAP3K1和MAP2K4基因，则向该患者给予有效量的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂。
如在此所用，术语“有效”和“有效性”包括药理学有效性和生理学安全性两者。药理学有效性是指在患者中产生所希望的生物作用的治疗能力。生理学安全性是指由所给予治疗在细胞、器官和/或生物体层面上造成的毒性程度或其他不良生理学作用(通常称为副作用)。“更不有效”意指该治疗产生治疗学上显著更低程度的药理学有效性和/或治疗学上更大程度的不良生理学作用。
筛选方法
根据另一个方面，提供了一种筛选患者以确立对用PI3K通路的上游组分的抑制剂进行治疗的适宜性的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定PI3K通路的上游组分的基因状态是野生型还是突变型；并且确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型。
根据另一个方面，提供了一种筛选患者以确立对用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗的适宜性的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定该PIK3CA基因或AKT基因是野生型还是突变型；并且确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型。
在另一个方面中，提供了一种筛选患者以确立对用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗的适宜性的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定该PIK3CA基因是野生型还是突变型；并且确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型。
在另一个方面中，提供了一种筛选患者以确立对用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂进行治疗的适宜性的方法，该方法包括：在先前从该患者分离的代表该癌症的样品中，确定该AKT基因是野生型还是突变型；并且确定先前从该患者分离的样品中的MAP3K1和MAP2K4基因是野生型还是突变型。
抑制剂及其用途
根据另一方面，提供了PI3K通路的上游组分的抑制剂用以治疗癌症患者的用途，该癌症患者的癌细胞已经被鉴定为具有在PI3K通路的上游组分中的突变、以及野生型MAP3K1和MAP2K4基因。
根据另一方面，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用以治疗癌症患者的用途，该癌症患者的癌细胞已经被鉴定为具有突变型PIK3CA基因或突变型AKT基因、以及野生型MAP3K1和MAP2K4基因。
在另一方面中，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用以治疗癌症患者的用途，该癌症患者的癌细胞已经被鉴定为具有突变型PIK3CA基因、以及野生型MAP3K1和MAP2K4基因。
在另一方面中，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用以治疗癌症患者的用途，该癌症患者的癌细胞已经被鉴定为具有突变型AKT基因以及野生型MAP3K1和MAP2K4基因。
根据另一方面，提供了用于在具有癌细胞的癌症的治疗中使用的、PI3K通路的上游组分的抑制剂，所述癌细胞被鉴定具有在PI3K通路的上游组分中的突变、以及野生型MAP3K1和MAP2K4基因。
根据另一方面，提供了用于在具有癌细胞的癌症的治疗中使用的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂，所述癌细胞被鉴定具有突变型PIK3CA基因、或突变型AKT基因以及野生型MAP3K1和MAP2K4基因。
在另外的一方面中，提供了用于在具有癌细胞的癌症的治疗中使用的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂，所述癌细胞被鉴定为具有突变型PIK3CA基因、以及野生型MAP3K1和MAP2K4基因。
在另外的一方面中，提供了用于在具有癌细胞的癌症的治疗中使用的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂，所述癌细胞被鉴定为具有突变型AKT基因、以及野生型MAP3K1和MAP2K4基因。
在另外的一方面中，提供了用于在具有癌细胞的癌症的治疗中使用的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂，所述癌细胞被鉴定为具有突变型PIK3CA基因、或突变型AKT基因以及野生型MAP3K1基因。
在另外的一方面中，提供了用于在具有癌细胞的癌症的治疗中使用的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂，所述癌细胞被鉴定为具有突变型PIK3CA基因、或突变型AKT基因以及野生型MAP2K4基因。
根据另一方面，提供了PI3K通路的上游组分的抑制剂用于制造一种药物的用途，该药物用于治疗具有癌细胞的癌症，所述癌细胞被鉴定为具有在PI3K通路的上游组分中的突变、以及野生型MAP3K1和MAP2K4基因。
根据另一方面，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用于制造一种药物的用途，该药物用于治疗具有癌细胞的癌症，所述癌细胞被鉴定为具有突变型PIK3CA基因或突变型AKT基因、以及野生型MAP3K1和MAP2K4基因。
在另外的一方面中，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用于制造一种药物的用途，该药物用于治疗具有癌细胞的癌症，所述癌细胞被鉴定为具有突变型PIK3CA基因、以及野生型MAP3K1和MAP2K4基因。
在另外的一方面中，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用于制造一种药物的用途，该药物用于治疗具有癌细胞的癌症，所述癌细胞被鉴定为具有突变型AKT基因、以及野生型MAP3K1和MAP2K4基因。
在另外的一方面中，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用于制造一种药物的用途，该药物用于治疗具有癌细胞的癌症，所述癌细胞被鉴定为具有突变型PIK3CA基因、或突变型AKT基因以及野生型MAP3K1基因。
在另外的一方面中，提供了PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂用于制造一种药物的用途，该药物用于治疗具有癌细胞的癌症，所述癌细胞被鉴定为具有突变型PIK3CA基因、或突变型AKT基因以及野生型MAP2K4基因。
在另外的一方面中，本发明涉及药物组合物，该药物组合物包括用于在具有癌细胞的癌症的预防和治疗中使用的、PI3K通路的上游组分的抑制剂，所述癌细胞被鉴定为具有在PI3K通路的上游组分中的突变、以及野生型MAP3K1和MAP2K4基因。
在再另外的方面中，本发明涉及药物组合物，该药物组合物包括用于在具有癌细胞的癌症的预防和治疗中使用的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂，所述癌细胞被鉴定为具有突变型PIK3CA基因或突变型AKT基因、以及野生型MAP3K1和MAP2K4基因。
这些药物组合物可采取溶液、悬浮液、乳液、片剂、丸剂、颗粒剂、胶囊、含有液体的胶囊、粉末、缓释制剂、栓剂、气雾剂、喷雾剂、悬浮液的形式或适用的任何其他形式。
给药可以是例如局部(即在需要药物组合物作用的地方直接施用该药物组合物)、肠内或口服(即药物组合物通过消化道被给予)、或肠胃外(即药物组合物通过由除消化道以外的其他途径给予，例如通过注射)。
在一个方面中，根据常规程序将活性化合物或其盐(PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂)和任选地另一种治疗或预防剂配制为适于人类静脉给药的药物组合物。通常，用于静脉给药的活性化合物是在无菌等渗水性缓冲液中的溶液。必要时，这些组合物还可以包括增溶剂。用于静脉给药的组合物可任选地包括局部麻醉剂例如利多卡因来缓解注射部位的疼痛。通常，这些成分单独地或混合在一起以单位剂型给予，例如，在气密密封容器例如安瓿瓶中作为干燥的冻干粉末或无水浓缩物。在通过输注给予活性化合物时，可以将其用含无菌药物级水或盐水的输液瓶分配。在通过注射给予活性化合物时，可以提供无菌注射用水或盐水的安瓿以便这些成分可在给予之前被混合。
用于口服递送的组合物可处于例如片剂、锭剂、水性或油性悬浮液、颗粒剂、粉末、乳液、胶囊、糖浆或酏剂的形式。口服给予的组合物可包含一种或多种任选的试剂，例如，甜味剂如果糖、阿斯巴甜或糖精；调味剂如薄荷、冬青油或樱桃；着色剂；以及防腐剂，以提供药学上可口的制剂。也可以使用时间延迟材料如单硬脂酸甘油酯或硬脂酸甘油酯。口服组合物可包括标准运载体，如甘露醇、乳糖、淀粉、硬脂酸镁，糖精钠、纤维素、碳酸镁等。此类运载体在特定方面是药物级。
根据本发明使用的组合物可以按照常规的方式使用一种或多种生理上可接受的载体或赋形剂配制。因此，该活性化合物和任选地另一种治疗剂或预防剂及其生理学上可接受的盐和溶剂化物可以配制为用于通过吸入或吹入(通过口或鼻)或口服、肠胃外或粘膜(例如颊、阴道、直肠、舌下)给药来给予的药物组合物。在一个方面中，使用局部或全身肠胃外给药。
对于口服给药，这些组合物可采取例如片剂或胶囊的形式，其是通过常规方法用药学上可接受的赋形剂来制备，这些赋形剂例如粘合剂(例如预胶化的玉米淀粉，聚乙烯吡咯烷酮或羟丙基甲基纤维素)；填充剂(例如乳糖、微晶纤维素或磷酸氢钙)；润滑剂(例如硬脂酸镁、滑石或二氧化硅)；崩解剂(例如马铃薯淀粉或羟基乙酸淀粉钠)；或润湿剂(例如十二烷基硫酸钠)。这些片剂可以通过本领域熟知的方法来包衣。用于口服给药的液体制剂可采取例如溶液、糖浆或悬浮液的形式，或者它们可以作为在使用前用水或其他合适的运载体配制的干燥产品呈现。此类液体制剂可以通过常规方法用药学上可接受的添加剂制备，这些添加剂例如助悬剂(例如，山梨醇糖浆、纤维素衍生物或氢化食用脂)；乳化剂(例如，卵磷脂或阿拉伯树胶)；非水性运载体(例如，杏仁油、油性酯、乙醇或分馏的植物油)；以及防腐剂(例如，对羟基苯甲酸甲酯或丙酯或山梨酸)。适当的话，这些制剂还可包含缓冲盐、调味剂、着色剂和甜味剂。
在一些方面中，本文披露的化合物或盐可以作为药物组合物给予，其中该药物组合物包含在0.1-1mg、1-10mg、10-50mg、50-100mg、100-500mg、或500mg-5g之间的所述活性化合物或其盐。
根据再另一方面，提供了一种试剂盒，该试剂盒包含处于合适的单位剂型的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂；一种测试物，该测试物适合提供分析结果以确定患者是具有PI3K通路的野生型上游组分还是突变型上游组分(例如PIK3CA基因或AKT基因)；一种测试物，该测试物适合提供分析结果以确定患者是具有野生型还是突变型的MAP3K1和MAP2K4基因；容器器件，该容器器件用于容纳PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂、以及PI3K通路上游组分、MAP3K1和MAP2K4测试物；以及可任选地使用说明书。
根据再另一方面，提供了一种试剂盒，该试剂盒包含处于合适的单位剂型的PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂；一种测试物，该测试物适合提供分析结果以确定患者是具有野生型还是突变型PIK3CA基因；一种测试物，该测试物适合提供分析结果以确定患者是具有野生型还是突变型的MAP3K1和MAP2K4基因；容器器件，该容器器件用于容纳PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂以及PIK3CA、MAP3K1和MAP2K4测试物；以及可任选地使用说明书。
在又另一方面中，提供了一种试剂盒，该试剂盒包含处于适合的单位剂型中的AKT抑制剂；一种测试物，该测试物适合提供分析结果以确定患者是具有野生型还是突变型AKT基因；一种测试物，该测试物适合提供分析结果以确定患者是具有野生型还是突变型的MAP3K1和MAP2K4基因；容器器件，该容器器件用于容纳该AKT抑制剂以及AKT、MAP3K1和MAP2K4测试物；以及可任选地使用说明书。
基因状态：野生型或者突变型
为了本说明书的目的，野生型的基因状态意为指示基因的正常或恰当表达以及所编码蛋白质的正常功能。相比之下，突变型状态意为指示异常或不适当的基因表达，或蛋白质功能改变的表达，与癌症中PI3K通路的突变型上游组分(例如PIK3CA或AKT)以及MAP3K1和MAP2K4的已知作用(如在此所述)一致。任何数目的遗传或表观遗传变化(包括(但不限于)突变、扩增、缺失、基因组重排或甲基化特征变化)可以导致突变型状态。然而，如果这些变化仍然引起正常蛋白质或功能上等效变异体的恰当表达，那么该基因状态被视为野生型。典型地将不产生功能突变型基因状态的变异体实例包括同义编码变异体和常见多态现象(同义或非同义)。如下文所讨论，基因状态可以通过功能分析来评估，或者它可以从与参考序列的检测偏差的性质推断。
在某些方面，PI3K通路的上游组分(例如PIK3CA或AKT基因)和/或MAP3K1和MAP2K4基因的野生型或突变型状态是通过在基因中非同义核酸变异的存在或不存在来确定。所观察的非同义变异对应于未标注功能作用的已知常见多态现象，不促成突变型基因状态。
在PI3K通路的上游组分(例如PIK3CA基因或AKT基因)的基因和/或表示突变型状态的MAP3K1/MAP2K4基因中的其他变异包括剪接位点变异，这些剪接位点变异在前体mRNA到mRNA的加工期间减少内含子/外显子接合点的识别。这可以导致外显子跳跃或在剪接mRNA中包括通常内含的序列(内含子滞留或采用隐含的剪接接合点)。这可以转而导致产生相对于正常蛋白质具有插入和/或缺失的异常蛋白质。因此，在其他方面中，如果在内含子/外显子接合点处存在改变剪接位点识别序列的变异体，那么该基因具有突变型状态。
在PI3K通路的上游组分的基因(例如该PIK3CA基因或AKT基因)和/或MAP3K1/MAP2K4基因中的非同义的蛋白质表达或活性耗减型突变和/或功能突变的丧失与本文描述的这些方面的使用是特别相关的，并且提供了本披露的单独方面。在另外的方面中，此类突变可以是移码突变、剪接区突变、无义突变和/或错义突变。
PIK3CA突变的表征
WO 2014/114928描述了于阿斯利康进行的关于乳腺癌(基于COSMIC数据库(韦尔科姆基金会桑格研究所(Welcome Trust Sanger Institute)，2011年9月)的调查，其中从覆盖>5千种人类肿瘤的整个数据集鉴别出PIK3CA基因中>55种不同的突变。大部分突变以<1％频率发生，3种以1％-3％频率发生，但4种突变占总PIK3CA突变的约88％。这些突变为C端激酶结构域中的激酶结构域错义突变H1047R(55％)和H1047L(5％)，以及螺旋结构域残基E545K(18％)和E542K(11％)。虽然并不旨在为穷尽性的，但其他普遍的乳腺癌突变的更长清单涵盖R38H、R38C、R88Q、N345K、C420R、E453Q、P539R、E542K、E545K、E545A、Q546K、Q546P、M1043I、M1043V、H1047R、H1047L、H1047Y。因此，诊断分析可以被构建成聚焦于检测最常见突变，由此允许鉴别大部分PIK3CA突变。举例来说，来自罗氏分子系统的Cobas(TM)PIK3CA突变测试经设计以检测从福尔马林固定的石蜡嵌埋的肿瘤样品分离的DNA中PIK3CA基因的外显子1、4、7、9以及20中的17种突变(E542K、E545A、E545G、E545K、E545D、Q546K、Q546R、Q546E、Q546L、N345K、C420R、R88Q、H1047L、H1047R、H1047Y、G1049R以及M1043I)。这一试剂盒能够拾取ER阳性乳腺癌中的约95％突变。突变分布在其他肿瘤类型中不同并且诊断策略可以相应地调适。举例来说，在子宫内膜癌中，相比于乳腺癌，扩散在整个PIK3CA基因编码序列中的突变分布更均匀并且蛋白质N端区域中的突变数目更多(由医学博士Douglas A.Levine传达，TCGA第2次年度研讨会，2012年11月28日)。
关于PIK3CA，参考序列可供用于基因(基因库登录号：NG_012113)、mRNA(基因库登录号：NM_006218)以及蛋白质(基因库登录号：NP_006209或Swiss-Prot登录号：P42336)。具体的参考序列分别显示在SEQ ID NO:5、10、15和20中。参考基因(基因组区域)序列包括上游序列的5000个碱基的下游序列的2000个碱基。PIK3CA内的突变众所周知(COSMIC数据库-韦尔科姆基金会桑格研究所)，并且本领域普通技术人员将能够基于与野生型比较DNA或蛋白质序列来确定PIK3CA基因状态，即特定PIK3CA基因为野生型抑或突变型。
清楚的是，披露的针对PIK3CA的基因和mRNA参考序列各自是代表性序列，并且出于本披露的目的，将仅用于比较目的的优选蛋白质参考序列显示在SEQ ID NO.20中。在正常个体中，每种基因存在两个拷贝(母本和父本拷贝)，这些拷贝将可能具有一些序列差异，此外在一个群体内将存在基因序列的许多等位基因变异体。视为野生型的其他序列包括具有以下的序列：核酸序列的一种或多种同义变化(这些变化不改变所编码的蛋白质序列)、改变蛋白质序列但不影响蛋白质功能的非同义常见多态现象(例如生殖系多态现象)以及内含子非剪接位点序列变化。
AKT突变的表征
AKT1错义点突变已经在包括乳腺癌的人类癌症中被鉴定(参见下面的参考文献1-3)。除了E17K外，人类癌症中最常见的AKT1突变、几种其他突变(L52R、C77F和Q79K)已经显示为功能性转化(参见下文参考文献4、5)。鉴于AKT1和AKT2蛋白之间的高序列同源性(Ensembl数据库-EMBl-EBI/韦尔科姆基金会桑格研究所(Welcome Trust SangerInstitute))，认为AKT2中的相应突变也在转化。
关于AKT1，参考序列可供用于基因(基因库登录号：NG_012188)、mRNA(基因库登录号：NM_005163)以及蛋白质(基因库登录号：NP_005154或Swiss-Prot登录号：P31749)。具体的参考序列分别显示在SEQ ID NO:1、6、11和16中。关于AKT2，参考序列可供用于基因(基因库登录号：NG_012038)、mRNA(基因库登录号：NM_001626)以及蛋白质(基因库登录号：NP_001617或Swiss-Prot登录号：P31751)。具体的参考序列分别显示在SEQ ID NO:2、7、12和17中。AKT1和AKT2内的突变以相对低的频率发生(COSMIC数据库-韦尔科姆基金会桑格研究所)，并且本领域普通技术人员将能够基于与野生型比较DNA或蛋白质序列来确定AKT1和AKT2基因状态，即具体的AKT1或AKT2基因是野生型还是突变型。
清楚的是，披露的针对AKT1和AKT2的基因、mRNA序列和蛋白质参考序列各自是代表性序列，并且出于本披露的目的，将仅用于比较目的的优选蛋白质参考序列显示在SEQID NO.16(针对AKT1)和SEQ ID NO.17(针对AKT2)中。在正常个体中，每种基因存在两个拷贝(母本和父本拷贝)，这些拷贝将可能具有一些序列差异，此外在一个群体内将存在基因序列的许多等位基因变异体。视为野生型的其他序列包括具有以下的序列：核酸序列的一种或多种同义变化(这些变化不改变所编码的蛋白质序列)、改变蛋白质序列但不影响蛋白质功能的非同义常见多态现象(例如生殖系多态现象)以及内含子非剪接位点序列变化。
1.Flatley,E.等人，PIK3CA-AKT pathway mutations in micropapillarybreast carcinoma[微乳头乳腺癌中的PIK3CA-AKT通路突变]，Human Pathology[人类病理学](2013)44，1320-1327。
2.Stemke-Hale,K.等人，An integrative genomic and proteomic analysis ofPIK3CA,PTEN and AKT mutations in breast cancer[乳腺癌中PIK3CA、PTEN和AKT突变的综合基因组学和蛋白质组学分析]，Cancer Research[癌症研究](2008)68，6084-6091。
3.Troxell,M.L.等人，High prevalence of PIK3CA/AKT pathway mutations inpapillary neoplasms ofthe breast[乳房乳头状瘤中PIK3CA/AKT通路突变的高发病率]，Modern Pathology[现代病理学](2010).23，27-37)。
4.Yi,K.等人，Functional analysis ofnon-hotspot AKT1mutants found inhuman breast cancers identifies novel driver mutations：implications forpersonalized medicine[人类乳腺癌中发现的非热点AKT1突变体的功能分析鉴定出新颖的驱动突变：对个性化医学的影响]，Oncotarget[肿瘤靶向](2012)4，29-34。
5.Carpten,J.D.等人，A transforming mutation in the pleckstrin homologydomain ofAKT1in cancer[癌症中的AKT1的普列克底物蛋白同源结构域的转化突变]，Nature[自然](2007)448，439-444。
MAP3K1和/或MAP2K4突变的表征
文献中的几个报道(参见下面的参考文献1-4)鉴定了MAP3K1和MAP2K4基因中的频繁突变。突变被分布在每个基因的编码序列上，其在任何功能结构域中没有明显的富集。这种模式指示该基因作为肿瘤抑制基因的功能，其中所谓的‘丧失功能’突变(剪接、无义和移码突变)消除功能蛋白质的表达。对于MAP3K1，在19％的情况中，突变导致编码序列中的非同义变化(Pham等人，Genes and Cancer[基因和癌症]2014，4：410-426)，但大多数情况下突变是移码缺失或插入(59％的突变)。实例是移码突变例如R273fs*27.I761fs*35和无义突变例如S431*和S1344*。因此，诊断测定可以被构建成聚焦于丧失功能突变的检测上，由此允许鉴别MAP3K1和MAP2K4突变。对于MAP3K1和MAP2K4，参考序列可供用于基因、mRNA和蛋白质(表1)。具体的参考序列的SEQ ID NO.如下文表1所示。
表1.
MAP3K1和MAP2K4内的突变是众所周知的(COSMIC数据库-韦尔科姆基金会桑格研究所)，并且本领域普通技术人员将能够基于与野生型比较DNA或蛋白质序列来确定基因状态，即具体的MAP3K1或MAP2K4基因是野生型还是突变型。
清楚的是，披露的针对MAP3K1和该MAP2K4的基因和mRNA以及蛋白质参考序列各自是代表性序列，并且出于本披露的目的，将仅用于比较目的的优选蛋白质参考序列显示在SEQ ID NO.19(针对MAP3K1)和在SEQ ID NO.18(针对MAP2K4)中。在正常个体中，每种基因存在两个拷贝(母本和父本拷贝)，这些拷贝将可能具有一些序列差异，此外在一个群体内将存在基因序列的许多等位基因变异体。视为野生型的其他序列包括具有以下的序列：核酸序列的一种或多种同义变化(这些变化不改变所编码的蛋白质序列)、改变蛋白质序列但不影响蛋白质功能的非同义常见多态现象(例如生殖系多态现象)以及内含子非剪接位点序列变化。
1.Comprehensive molecular portraits ofhuman breast tumours[癌症基因组阿特拉斯网络，人类乳房肿瘤的综合分子图谱]，Nature[自然](2012)490，61-70。
2.Stephens,P.J.等人，The landscape of cancer genes and mutationalprocesses in breast cancer[癌基因的景观和乳腺癌中的突变过程]，Nature[自然](2012)486，400-404。
3.Ellis,M.J.等人，Whole-genome analysis informs breast cancer responseto aromatase inhibition[全基因组分析说明乳腺癌对芳香酶抑制的响应]，Nature[自然](2012)486，353-60。
4.Curtis，C.等人，The genomic and transcriptomic architecture of 2,000breast tumours reveals novel subgroups[2000个乳房肿瘤的基因组和转录组结构揭示新颖亚组]，Nature[自然](2012)486，346-352。
确定治疗有效的可能性的方法
根据另一方面，提供了在受癌症影响的人类患者中，使用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂治疗的有效的可能性的方法，该方法包括：相对于野生型基因，检测所述患者的PI3K通路的上游组分(例如PIK3CA基因或AKT基因)中至少一种非同义核酸变异的存在或不存在；相对于野生型基因，检测所述患者的MAP3K1基因和MAP2K4基因中至少一种非同义核酸变异的存在或不存在；其中在PI3K通路的上游组分(例如PIK3CA基因或AKT基因)中至少一个非同义核酸变异的存在，以及在MAP3K1基因和MAP2K4基因两者中至少一个非同义核酸变异的不存在，指示用PI3K通路的上游组分的抑制剂(例如PI3K-α抑制剂或AKT抑制剂)的治疗可能是有效的。
根据另一方面，提供了评估个体对使用PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂或AKT抑制剂治疗的易感性的方法，该方法包括：
(i)确定来自个体的癌细胞DNA中PI3K通路的上游组分(例如PIK3CA基因或AKT基因)的非同义突变状态；
(ii)确定来自个体的癌细胞DNA中MAP3K1基因和MAP2K4基因的非同义突变状态；并且
(iii)通过参考在癌细胞中PI3K通路的上游组分(例如PIK3CA基因或AKT基因)以及MAP3K1基因和MAP2K4基因的非同义突变状态，确定个体对用PI3K通路的上游组分的抑制剂(例如PI3K-α抑制剂或AKT抑制剂)的治疗的可能易感性。
存在本领域普通技术人员可获得的以确定PIK3CA的基因状态的许多技术。基因状态可以通过测定核酸序列来确定。这可以经由对全长基因进行直接测序或分析该基因内的特异性位点，例如一般突变位点。
用于确定PIK3CA基因为野生型抑或突变型的替代性手段为评估转录基因的功能。这一PIK3CA基因的功能突变产生脂质激酶活性增加的蛋白质，引起细胞中该路径的下游信号传导增加，包括(但不限于)Akt和S6激酶的激活。当PIK3CA变异体在细胞中表达时，用于评估它们功能状态的分析包括(但不限于)：
(i)具有PIK3CA基因三磷酸磷脂酰肌醇(PI(3,4,5)P3)的激酶活性的产物的增加的产生；
(ii)磷酸化Akt或S6激酶的增加的含量；
(iii)用PIK3CA变异体转染的NIH-3T3细胞的增加的聚集和集落形成；(Ikenoue T等人，Cancer Res.[癌症研究]，2005 65，4562-4567)。
用于分析相关的DNA样品的可替代方法涉及大规模平行测序(也称为下一代测序，或NGS)。大规模平行测序方法可用于确定这些基因的基因型，并且例如，但不限于，亿明达公司(Illumina)、离子激流公司(Ion Torrent)、西格诺公司(Sequenom)和牛津纳米孔平台(Oxford Nanopore platforms)。
样品
用于测试基因状态的患者样品可以是从个体获得或可获得的任何包含癌组织或癌细胞的样品，或者是包含癌症核酸例如可能在血液/血浆或其他体液中发现的循环游离DNA(cfDNA)的样品。测试样品宜为从个体获得的血液样品、口腔抹片、活检体或其他体液或组织。特定实例包括：循环癌细胞、血浆或血清中的循环DNA、从卵巢癌患者的腹水液分离的细胞、具有癌症的患者肺内的肺痰、来自乳腺癌患者的细针抽出物、尿液、外周血液、细胞刮片、毛囊、点式活检或面颊样品。
应了解，测试样品同样可以为对应于测试样品中的序列的核酸序列，换句话说，样品核酸中的所有或一部分区域可以在分析之前先使用任何便利技术(例如聚合酶链反应(PCR))扩增。核酸可以为基因组DNA或者分级的或全细胞RNA。在特定方面中，RNA为全细胞RNA且直接用作使用随机引物或poly A引物来标记一个第一链cDNA的模板。可以根据标准方法从测试样品提取该样品中的核酸或蛋白质(参见Green和Sambrook编，MolecularCloning:A Laboratory Manual[分子克隆实验指南]，(2012，第4版，第1-3卷，ISBN9781936113422)，冷泉港实验室出版社(Cold Spring Harbor Laboratory Press)，冷泉港，纽约州)。
本发明的诊断方法可以使用先前从个体或患者获取的样品进行。这些样品可以通过冷冻或固定以及嵌埋于福尔马林-石蜡或其他介质中来保存。可替代地，可以获得且使用包含新鲜癌细胞的样品。
本说明书披露的方法可以使用来自任何适合的癌症的细胞来应用。本文描述了适合的用于治疗的癌症。
突变的流行率
在临床肿瘤中广泛发现PIK3CA突变，但每一基因突变的流行率随肿瘤组织类型显著不同。举例来说，PIK3CA突变在乳腺癌中相对常见，但在肾脏肿瘤中相对罕见(表2)。
表2：临床样品中PIK3CA突变的流行率。PIK3CA信息来源为COSMIC数据库(v62版)。本披露的患者选择方法可以尤其有用于存在PIK3CA突变的高发生率的疾病(组织)区段(例如乳房、泌尿道、子宫内膜、大肠、子宫颈等)。
临床肿瘤中发现在AKT1和AKT2中的突变广泛存在，突变的流行率随肿瘤组织类型而变化(表3和4)。
组织 AKT1突变流行率(％)
膀胱 3
乳房 2.4
子宫 1.6
子宫颈 1.5
结肠直肠 1.4
前列腺 1.3
肺腺 1.2
成神经管细胞瘤 1.1
胃 1
肝 0.9
黑色素瘤 0.9
头和颈 0.7
胰脏 0.7
甲状腺 0.7
肺鳞状细胞 0.6
肾脏肾乳头状细胞癌 0.6
肾脏肾透明细胞癌 0.5
多发性骨髓瘤 0.5
急性髓细胞性白血病 0.3
多形性成胶质细胞瘤 0.3
卵巢 0.2
表3.在临床癌症组群中AKT1突变的流行率。本披露的患者选择方法可以尤其有用于存在AKT1突变的高发生率的疾病(组织)区段中。
表4.在临床癌症组群中AKT2突变的流行率。本披露的患者选择方法可以尤其有用于存在AKT2突变的高发生率的疾病(组织)区段中。
在包括乳腺癌、胃癌和子宫癌的许多癌症类型中发现MAP3K1的突变(表5)。虽然所有乳腺癌研究中的流行率总共为6％左右，但在特定类型的乳腺癌中可能更高。例如，在管腔A型、HER2阳性/ER+癌症中发现在乳腺癌中所见的75％的变化，其中，MAP3K1突变的流行率可以是在11％和16％之间。
表5：临床样品中MAP3K1突变的流行率。MAP3K1信息来源是cBioPortal数据库。本披露的患者选择方法可以尤其有用于存在MAP3K1突变的高发生率的疾病(组织)区段。
在包括乳腺癌、结肠癌、胰腺癌和胃癌的许多癌症类型中发现MAP2K4的突变(表6)。虽然所有乳腺癌研究中的流行率总共为3％左右，但在特定类型的乳腺癌中可能更高。例如，在管腔A型HER2-阴性/ER+癌症中发现在乳腺癌中所见的75％的变化，其中，MAP2K4突变的流行率可以是在8％和10％之间。
表6：临床样品中MAP2K4突变的流行率。MAP2K4信息来源是cBioPortal数据库。本披露的患者选择方法可以尤其有用于存在MAP2K4突变的高发生率的疾病(组织)区段。
如本领域普通技术人员将显而易知，随着新的且更全面的数据从如TCGA(癌症基因组图谱(The Cancer Genome Atlas))和ICGC(国际癌症基因组联盟(InternationalCancer Genome Consortium))的人类癌症基因组分析协会(Human Cancer Genomeprofiling consortia)出现，这一频率数据持续地得到改进与更新。因此，具有PIK3CA或AKT依赖性和MAP3K1和/或MAP2K4依赖性的另外的肿瘤类型可以被鉴定，并且适合用PI3K通路的上游组分的抑制剂(例如PI3K-α抑制剂或AKT抑制剂)进行治疗，如本文所述的。
相关适应症
在表明癌症治疗的情况下，应了解，这可能是指预防转移以及治疗转移(即癌症扩散)。因此，本文披露的方法能够用于治疗不具有转移的患者而终止转移发生，或延长转移发生前的时间段，以及针对已具有转移的患者来治疗转移本身。此外，癌症治疗可能指治疗一种或多种确定的原发性肿瘤和一种或多种发展中的原发性肿瘤。
因此，在一个方面中，癌症治疗涉及预防转移。
在另一个方面中，癌症治疗涉及治疗转移。
在另一个方面中，癌症治疗涉及治疗一种或多种确定的原发性肿瘤或一种或多种发展中的原发性肿瘤。
在此，癌症的治疗可以是指预防癌症本身。
在一方面中，癌症被提及时，它可以指的是对PI3K通路的上游组分的抑制敏感的肿瘤，这些上游组分参与导致肿瘤细胞的增殖、存活、侵袭和迁移能力的信号转导步骤。
在一个方面中，癌症是在PI3K通路的上游组分例如PIK3CA或AKT基因中携带突变的癌症。
在一个方面中，癌症是基于突变、扩增或其他畸变显示PIK3CA依赖性或AKT依赖性的癌症。
在一个方面中，该癌症选自乳腺癌、胃癌、食管癌、肺癌、头颈癌、子宫内膜癌、卵巢癌、子宫颈癌、外阴癌、多发性骨髓瘤、淋巴瘤、白血病、膀胱癌、脑癌、结肠直肠癌、胆囊癌、胆管癌、皮肤癌、胰腺癌、睾丸癌、甲状腺癌、肾癌、肝癌、外阴癌、阴茎癌和其他PI3-激酶依赖性癌症。
在一个方面中，该癌症是乳腺癌。
在一个方面中，该癌症是雌激素受体阳性乳腺癌。
在一个方面中，该癌症是雌激素受体阳性的管腔乳腺癌。
在一个方面中，该癌症是雌激素受体阳性的管腔A型乳腺癌。
在一个方面中，该癌症处于转移性状态。
在一个方面中，该癌症处于非-转移性状态。
检测核酸的方法
在本发明的上下文中，可以采用PI3K通路的突变型上游组分(例如PIK3CA或AKT)以及突变型MAP3K1或MAP2K4核酸的检测来预测对药物治疗的反应。因为这些基因中的突变发生在DNA层面，所以本发明方法可以基于检测基因组DNA的突变或变化，以及转录物和蛋白质本身。所希望的可以是通过分析转录物和/或多肽来确认基因组DNA突变，以便确保所检测的突变实际上在该受试者中表达。
本领域普通技术人员将清楚，存在可以用于检测基因中一个或多个位置处变异体核苷酸的存在或不存在的大量分析程序。一般来说，等位基因变异的检测需要突变辨别技术、任选的扩增反应(如基于聚合酶链反应的扩增反应)以及任选的信号产生系统。在本领域中可获得多种突变检测技术并且这些突变检测技术可以与信号产生系统组合使用，在本领域中可获得许多信号产生系统。检测等位基因变异的许多方法由以下文献进行了综述：Nollau等人，Clin.Chem.[临床化学]，1997,43,1114-1120；Anderson SM.，Expert Rev Mol Diagn.[分子诊断学专家评论]，2011,11,635-642；Meyerson M.等人，Nat Rev Genet.[自 然综述·遗传学]，2010,11,685-696综述；以及综述于标准教科书中，例如“Laboratory Protocols for Mutation Detection[突变检测的实验室方案]”，由U.Landegren编，牛津大学出版社(Oxford University Press)，1996和“PCR”，第2版，由Newton和Graham编，拜尔斯科学出版社有限公司(BIOS Scientific Publishers Limited)，1997。
如上所指出，测定具有癌症的患者中存在或不存在PIK3CA基因的特定变化或多种变化可以按多种方式进行。此类测试通常使用从生物样品收集的DNA或RNA进行，这些生物样品例如组织活检体、尿液、大便、痰、血液、细胞、组织刮片、乳房抽出物或其他细胞物质，并且可以通过多种方法进行，这些方法包括(但不限于)PCR、与等位基因特异性探针杂交、酶突变检测、错配的化学裂解、质谱或DNA测序，包括微测序。
适合的突变检测技术包括扩增阻碍突变系统(ARMSTM)、扩增阻碍突变系统线性延伸(ALEXTM)、竞争性寡核苷酸引发系统(COPS)、塔克曼(Taqman)、分子信标(MolecularBeacons)、限制性片段长度多态现象(RFLP)以及基于限制位点的PCR以及荧光共振能量转移(FRET)技术。
技术人员会意识到与上述那些相似的技术可用于检测AKT和/或MAP3K1或MAP2K4基因中的突变。在特定方面中，用于测定生物标记基因内的核苷酸所用的方法是选自：等位基因特异性扩增(等位基因特异性PCR)(如扩增阻碍突变系统(ARMS))、测序、等位基因辨别分析、杂交、限制性片段长度多态现象(RFLP)或寡核苷酸连接分析(OLA)。
在特定方面中，与等位基因特异性探针杂交可以通过以下来进行：(1)溶液中结合到具有经标记样品的固相(例如玻璃、硅、尼龙膜)的等位基因特异性寡核苷酸，例如，如同在许多DNA芯片应用中；或(2)溶液中的经结合样品(通常为经克隆DNA或PCR扩增的DNA)和经标记寡核苷酸(或者等位基因特异性或者较短以便允许通过杂交来测序)。诊断测试可以涉及一组变化，通常在固体支撑物上，这使得能够同时测定一种以上变化。这些杂交探针在本领域中为熟知的(参见例如Green和Sambrook编，Molecular Cloning:A LaboratoryManual[分子克隆实验指南]，(2012，第4版，第1-3卷，ISBN 9781936113422)，冷泉港实验室出版社，冷泉港，纽约州)并且可以跨越两个或更多个变化位点。
因此，在一个方面中，检测到至少一种突变的存在或不存在使包含假定突变位点的PIK3CA或AKT核酸和/或MAP3K1和MAP2K4核酸与至少一个核酸探针接触。探针优先在选择性杂交条件下与包括变化位点且在该变化位点处包含互补核苷酸碱基的核酸序列杂交。杂交可以使用本领域普通技术人员已知的标记用可检测标记来检测。这些标记包括(但不限于)放射性、荧光、染料以及酶标记。
在另一个方面中，检测到至少一种突变的存在或不存在使包含假定突变位点的PIK3CA或AKT核酸和/或MAP3K1和MAP2K4核酸与至少一个核酸引物接触。引物优选在选择性杂交条件下与包括变化位点且在该变化位点处包含互补核苷酸碱基的核酸序列杂交。
用作特异性扩增的引物的寡核苷酸可以携带与分子中间(因此扩增取决于差异性杂交；参见例如Gibbs等人，1989，Nucl.Acids Res.[核酸研究]，17，2437-248)或在一个引物的3'远端处的所关注的突变互补的核苷酸碱基，其中在恰当的条件下，可以防止错配或减少聚合酶延伸(参见例如Prossner，1993，Tibtech[生物技术趋势]，11 238)。
在又另一个方面中，检测至少一种突变的存在或不存在包括对至少一种核酸序列进行测序且比较所获得的序列与已知野生型核酸序列。
可替代地，至少一种突变的存在或不存在包括质谱测定至少一种核酸序列。
在一个方面中，检测至少一种核酸变化的存在或不存在包括进行聚合酶链反应(PCR)。使包含假设变化的靶核酸序列扩增且测定经扩增的核酸的核苷酸序列。测定经扩增的核酸的核苷酸序列包括对至少一个核酸区段进行测序。可替代地，扩增产物可以使用能够根据它们的大小分离扩增产物的任何方法来分析，包括自动化和手动凝胶电泳等。
基因组核酸中的突变有利地通过基于扩增核酸片段中的活动位移的技术来检测。举例来说，Chen等人，Anal Biochem[分析生物化学]1996，239，61-9中描述通过竞争性活动位移分析来检测单碱基突变。此外，基于Marcelino等人，BioTechniques[生物技术]1999，26，1134-1148的技术的分析可商购。
在特定实例中，可以使用毛细管异双螺旋分析以基于毛细管系统中双螺旋核酸的活动位移来检测突变的存在作为存在错配的结果。
从样品产生用于分析的核酸一般需要核酸扩增。许多扩增方法依赖于酶链反应(如聚合酶链反应、连接酶链反应或自持续序列复制)或来自已进行克隆的所有或一部分载体。优选地，根据本发明的扩增为指数扩增，如通过例如聚合酶链反应所展现。
许多靶标和信号扩增方法已描述于文献中，例如这些方法的总体综述描述于Landegren,U.等人，Science[科学]，1988 242，229-237和Lewis,R.，Genetic Engineering News[基因工程新闻]1990，10，54-55中。这些扩增方法可以用于本发明的方法中，并且包括聚合酶链反应(PCR)、原位PCR、连接酶扩增反应(LAR)、连接酶杂交、Qβ噬菌体复制酶、基于转录的扩增系统(TAS)、基因组扩增与转录物测序(GAWTS)、基于核酸序列的扩增(NASBA)以及原位杂交。适用于不同扩增技术的引物可以根据本领域中已知的方法制备。
聚合酶链反应(PCR)为核酸扩增方法，尤其描述于美国专利第4,683,195号和第4,683,202号中。PCR由DNA聚合酶产生的引物延伸反应的重复周期组成。靶DNA是热变性的且使两个寡核苷酸杂交，这两个寡核苷酸囊括待扩增的DNA相对链上的靶序列。这些寡核苷酸变成引物用于DNA聚合酶。通过引物延伸复制DNA来制造两个链的第二拷贝。通过重复热变性、引物杂交以及延伸的周期，靶DNA可以在约二到四小时内扩增一百万倍或更多。PCR为分子生物学工具，它必须与检测技术结合用于测定扩增结果。PCR的优点为它通过将靶DNA的量在约4小时内扩增一百万到十亿倍来增加敏感性。PCR可以用于在诊断背景中扩增任何已知核酸(Mok等人，Gynaecologic Oncology[妇科肿瘤学]，1994，52:247-252)。
如扩增阻碍突变系统(ARMSTM)的等位基因特异性扩增技术(Newton等人，Nucleic Acids Res.[核酸研究]，1989，17，2503-2516)也可以用于检测单碱基突变。在恰当的PCR扩增条件下，位于引物的3'末端的单碱基错配对完全匹配的等位基因的优先扩增来说已足够(Newton等人，1989，前述)，允许辨别密切相关的物质。使用上述引物的扩增系统的基础是具有错配3'-残基的寡核苷酸在恰当的条件下将不充当PCR引物。这一扩增系统允许在琼脂糖凝胶电泳之后仅通过检查反应混合物来进行基因分型。
扩增产物的分析可以使用能够根据它们的大小分离扩增产物的任何方法来进行，包括自动化和手动凝胶电泳、质谱等。
核酸分离、扩增以及分析方法对本领域普通技术人员来说为常规的并且方案的实例可以见于例如Green和Sambrook编，Molecular Cloning:A Laboratory Manual[分子克隆实验指南]，(2012，第4版，第1-3卷，ISBN 9781936113422)，冷泉港实验室出版社，冷泉港，纽约州)。PCR扩增中所用方法的尤其有用的方案来源是PCR(Basics:From Background to Bench)[PCR(基础：从背景到实验台)]，M.J.McPherson，S.G.Mailer，R.Beynon，C.Howe，斯普林格出版社(Springer Verlag)；第1版(2000年10月15日)，ISBN:0387916008。
本说明书还描述了预测和诊断试剂盒，这些试剂盒包括用于扩增PIK3CA基因或AKT基因和/或MAP3K1基因和MAP2K4基因中的靶核酸的简并引物；以及说明书，包括扩增方案和结果分析。该试剂盒也可以可替代地包括用于进行扩增以及扩增产物的分析的缓冲剂、酶以及容器。该试剂盒也可以为包括其他工具(如DNA微阵列或其他支撑物)的筛选或诊断试剂盒的组件。优选地，该试剂盒还提供一个或多个对照模板，如从正常组织样品分离的核酸；和/或一系列代表参考基因中的不同变化的样品。
在一个方面中，该试剂盒提供两个或更多个引物对，每一对均能够扩增参考(PIK3CA或AKT，和/或MAP3K1和MAP2K4)基因的不同区域(每一区域具有可能变化位点)，由此提供用于分析生物样品在一个反应或若干平行反应中的若干基因变化的表达的试剂盒。
试剂盒中的引物可以经标记(例如荧光标记)以促进检测扩增产物以及随后分析核酸的变化。该试剂盒还可以允许在一个分析中检测一种以上变化。组合试剂盒将因此包括能够扩增参考基因的不同区段的引物。这些引物可以例如使用不同的荧光标记进行差示性标记，以便在这些变化之间进行区分。
还披露了检测PIK3CA或AKT和/或MAP3K1和MAP2K4突变的试剂盒的用途，所述试剂盒包括但不限于目前市售的PIK3CA突变检测试剂盒和AKT突变检测试剂盒。
对于所有以上方面，所测定/鉴别的PIK3CA的突变体形式处于基因中的所有位置处。
对于所有以上方面，使用如乳腺癌的肿瘤作为一个实例，所测定/鉴别的PIK3CA的特定突变体形式为在R38、R88、N345、C420、E453、P539、E542K、E545K、Q546、M1043、M1043以及H1047R位置处者。
对于所有以上方面，使用如乳腺癌的肿瘤作为一个实例，所测定/鉴别的PIK3CA的特定突变体形式为在E542、E545以及H1047位置处者。
对于所有以上方面，所测定/鉴别的AKT的突变体形式处于基因中的所有位置处。
对于所有以上方面，使用如乳腺癌的肿瘤作为一个实例，所测定/鉴别的AKT的特定突变体形式为在E17K、L52R、C77F以及Q79K位置处者。
对于所有以上方面，使用如乳腺癌的肿瘤作为一个实例，所测定/鉴别的AKT的特定突变体形式为在E17K位置处者。
对于所有以上方面，所测定/鉴别的MAP3K1的突变体形式处于基因中的所有位置处。
对于所有以上方面，所测定/鉴别的MAP3K1的突变体形式是以导致过早翻译终止的突变为特征的那些形式。
对于所有以上方面，所测定/鉴别的MAP3K1的突变体形式是以导致丧失功能的突变为特征的那些形式。
对于所有以上方面，所测定/鉴别的MAP3K1的突变体形式是以导致编码序列的非同义变化的突变为特征的那些形式。
对于所有以上方面，所测定/鉴别的MAP3K1的突变体形式是处于R273fs*27.I761fs*35，S431*和S1344*位置处者。
对于所有以上方面，所测定/鉴别的MAP2K4的突变体形式处于基因中的所有位置处。
对于所有以上方面，所测定/鉴别的MAP2K4的突变形式是以导致过早翻译终止的突变为特征的那些形式。
对于所有以上方面，所测定/鉴别的MAP2K4的突变形式是以导致丧失功能的突变为特征的那些形式。
对于所有以上方面，所测定/鉴别的MAP2K4的突变形式是以导致编码序列的非同义变化的突变为特征的那些形式。
对于所有以上方面，所测定/鉴别的MAP2K4的突变体形式处于R273fs*27.I761fs*35，S431*以及S1344*位置处者。
贯穿本说明书，提及了PI3K通路的上游组分的基因状态。为了避免疑问，当描述涵盖PI3K通路的上游组分的任何特定方面时，提供了以下另外的方面，这些另外的方面涵盖PI3K基因(包括PIK3CA、PIK3CB、PIK3CD和PIK3CD基因)的状态、AKT的同种型(包括AKT1、AKT2和AKT3基因)的状态、PTEN基因的状态、PDK1基因的状态、SGK基因的状态、INPP4B基因的状态、INPP5D基因的状态、PIK3R1基因的状态和PIK3R2基因的状态。特定的另外的方面是本文描述的任何方面，其中仅涵盖PIK3CA基因的状态。另外特定的另一个方面是本文描述的任何方面，其中仅涵盖AKT基因的状态。
类似地，并且为了避免疑问，当描述涵盖MAP3K1和MAP2K4基因两者的任何特定方面时，提供了涵盖仅MAP3K1基因的状态的另外的方面以及涵盖仅MAP2K4基因的状态的另一方面。
此外，并且为了避免疑问，当本说明书中提及AKT基因时，则另外的方面是选自AKT1和AKT2的基因。再另一方面，该基因仅是AKT1基因。在又另一方面中，该基因仅是AKT2基因。
另外，贯穿本说明书，提及了PI3K通路的上游组分的抑制剂。为了避免疑问，当描述涵盖PI3K通路的上游组分的抑制剂的任何特定方面时，提供了涵盖PI3K同种型的抑制剂(包括PI3K-α、PI3K-β和PI3K-δ抑制剂)的另外的方面以及涵盖AKT的同种型的抑制剂(包括AKT1、AKT2、AKT1/2和AKT3抑制剂)的另外的方面。
在再另一方面中，当提及PI3K通路的上游组分的抑制剂时，所述抑制剂选自PI3K-α抑制剂和AKT抑制剂。
类似地，当描述涵盖来自PI3K-α抑制剂和AKT抑制剂的抑制剂的选择的任何特定方面时，提供了其中所述抑制剂仅是PI3K-α抑制剂的另外的方面以及其中所述抑制剂仅是AKT抑制剂的另外的方面。
此外，也为避免疑问，无论何时本说明书提及PI3K-α抑制剂，则提供其中所述抑制剂是1-(4-(5-(5-氨基-6-(5-叔丁基-1,3,4-噁二唑-2-基)吡嗪-2-基)-1-乙基-1H-1,2,4-三唑-3-基)哌啶-1-基)-3-羟基丙-1-酮(化合物A)的另一方面。
此外，并且为了避免疑问，当本说明书中提及AKT抑制剂时，则另一方面是选自AKT1和AKT2的AKT同种型的抑制剂。在另一方面中，抑制剂是AKT1/2同种型的双重抑制剂。在再另一方面中，抑制剂仅是同种型AKT1的抑制剂。在另一方面中，抑制剂仅是同种型AKT2的抑制剂。
此外，也为避免疑问，无论何时本说明书提及AKT抑制剂，则提供其中所述抑制剂是4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基-丙基]-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺(化合物B)的另一方面。
实例
实验方案中所用的缩写：
PIP2：PI(4,5)P2，磷脂酰肌醇4,5-双磷酸酯
s.c.：皮下
ATP：三磷酸腺苷
DMSO：二甲亚砜
TRIS：三(羟甲基)氨基甲烷
CHAPS：3-[(3-胆酰胺基丙基)二甲基铵基]-1-丙烷磺酸盐
DTT：二硫苏糖醇
FBS：胎牛血清
DMEM：杜尔贝科氏改良伊格尔培养基(Dulbecco's Modified Eagle Medium)
EDTA：乙二胺四乙酸
EGTA：乙二醇四乙酸
BSA：牛血清白蛋白
PBS：磷酸盐缓冲盐水
HRP：辣根过氧化酶
RPMI：洛斯维公园纪念研究所(Roswell Park Memorial Institute)1640培养基
4NQO：4-硝基喹啉N-氧化物
EMEM：伊格尔氏最低必需培养基
CO2：二氧化碳
PBST：磷酸盐缓冲盐水/Tween
Ab：抗体
MTS试剂：[3-(4,5-二甲基噻唑-2-基)-5-(3-羧基甲氧基苯基)-2-(4-
磺苯基)-2H-四唑鎓，内盐；MTS]和电子偶联试剂(吩嗪硫酸甲酯)PMS。
实例1：已知细胞系突变的PIK3CA-MAP3K1双突变体谱的分析。
为了测试MAP3K1功能丧失对PIK3CA突变体背景中肿瘤细胞对PI3K通路抑制剂的敏感性的影响，对鉴定的临床样品中的突变和存在于可获得于公共区域中的细胞系中的那些突变进行了全面调查。这些细胞系都没有与所需的PIK3CA-MAP3K1双突变体谱匹配的基因谱。发现含有PIK3CA和MAP3K1突变的仅有细胞系还包含其他基因中的缺失，这将潜在地混淆结果并产生不想要的离位效应的可能性(图1)。
实例2：含有PIK3CA和MAP3K1突变两者的细胞系的产生以及MAP3K1表达丧失对PI3K通路的上游组分的抑制剂的活性的影响的分析。
在不存在可用的细胞系的情况下，通过两种方法产生再现PIK3CA突变和MAP3K1失活的细胞系模型，所述方法包括：第一，通过siRNA转染瞬时敲低MAP3K1的表达(图2A)；以及第二，通过使用精确的基因编辑技术在MAP3K1基因中永久地诱导插入或缺失(图2B)。
独立于该途径，在PIK3CA突变细胞系的背景下MAP3K1失活导致pAKT(T308)水平的提高。
方法1：通过siRNA转染来瞬时敲低MAP3K1的表达
MCF7细胞来源于人乳腺癌。它们的特征在于表达雌激素受体(ER)并且缺乏EGFR家族的生长因子受体HER2的表达。由于这些原因，这种细胞系被认为是ER+/HER2-管腔型乳腺癌的可接受的模型。第二细胞系，T47D具有类似的特征。此外，MCF7和T47D细胞在PIK3CA基因中携带“热点”突变，并且在用PI3Kα同种型选择性化合物处理后对通路抑制和存活力两者均最敏感。MCF7携带突变c.1633G>A(p.E545K)，并且T47D携带突变c.3140A>G(p.H1047R)。
通过蛋白质印迹法监测全长蛋白的表达来测试可商购的siRNA双链体的若干来源(西格玛(Sigma)、Dharmacon和凯杰(QIAGEN))的MAP3K1的有效敲低。在选择最佳表现的siRNA双链体后，在有或没有先前siRNA介导的MAP3K1敲低的情况下，用PI3Kα选择性抑制剂化合物A处理细胞。由于siRNA敲低效应的瞬时性质，细胞活力测定是不可行的。
RNA干扰(RNAi)和质粒转染的方案。
使用Lipofectamine RNAiMax(英杰公司(Invitrogen))和FuGENE HD(罗氏公司(Roche))瞬时转染细胞。ON-TARGETplus MAP3K1 siRNA和购自Dharmacon的乱序阴性对照被转染至终浓度为40nM。使用10ug DNA与15ul Fugene HD混合并且孵育24和48小时进行质粒的转染。
在MCF7、T47D细胞中测量磷酸化AKT(T308)的方案。
低传代MCF7和T47D细胞从AZ细胞库保藏中心(AZ Cell Bank Collection)获得并如先前描述的进行培养(Avivar-Valderas等人，MCB，31(17)：3616-29，2011)。野生型和MCF10A-PI3KαH1047R由地平线探索公司(Horizon Discovery)提供。
培养后，将细胞裂解，并且将蛋白通过免疫印迹法(IB)进行分析(AvivarValderas等人，MCB，31(17)：3616-29，2011)。使用针对MAP3K1(圣克鲁什(Santa Cruz))磷酸AKT(Thr308)(细胞信号传导技术公司(Cell Signaling Technology))和粘着斑蛋白(西格玛)的抗体进行膜印迹。用辣根过氧化物酶(HRP)缀合的二级抗体和化学发光测定法检测结合的抗体(Avivar-Valderas等人，MCB，31(17)：3616-29，2011)。
方法2：在MAP3K1基因中产生插入或缺失
为了进一步测试MAP3K1失活的效果并模拟在人乳房肿瘤中发现的突变，瑞典阿斯利康公司(AstraZeneca Sweden)使用精确的基因编辑技术在MAP3K1基因中产生插入或缺失以使其表达失活。在用期望的构建体转染MCF7和MCF10A-PI3KαH1047R后，通过细胞分选选择单独的细胞并且使其作为克隆生长。MCF7突变体克隆是MCF7-CR1和MCF7-CR2。在MCF10A-PI3KαH1047R细胞中产生的突变体克隆是MCF10A-H1047R-CR1和MCF10A-H1047R-CR2。
用于产生和验证MAP3K1突变体克隆的方案。
使用先前描述的程序设计gRNA(Doudna等人，Science[科学]346，(6213)：1258096，2014；Ran等人，Cell[细胞]154，1380-9，2013；Tsai等人，Nature Biotechnology[自然生物科技期刊]，32，569-576，2014)。将靶向MAP3K1座位的gRNA亚克隆到gRNA-Cas9-GFP编码载体中，并且随后确认序列。使用FuGENE HD(罗氏公司)瞬时转染细胞并且用绿色荧光(GFP)分选。通过有限稀释来选择单克隆培养物。
将基因组DNA通过使用凯杰试剂盒从扩增的克隆中分离。用以扩增靶向区的PCR反应是通过使用融合闪速(Fusion Flash)DNA聚合酶(富酶泰斯公司(Fermentas))进行。将10μL PCR产物直接变性(95℃，10分钟)、杂交(-0.1℃/1秒)，并且用CelI酶(重组公司(recombinetic))处理。将消化产物使用10％丙烯酰胺凝胶电泳进行分析。
突变基因组DNA的桑格(Sanger)测序：用于CelI测定的相同的PCR产物是拓扑异构酶(Topo)-克隆的(生命科技公司(Life Technologies))，并且将每个样品中至少5个单独的克隆的质粒DNA进行分离并使用M13反向引物进行测序。
实例2A
使用通过siRNA转染产生的细胞系，通过监测PI3Kα下游的信号传导读出的抑制水平来检查MAP3K1表达丧失对化合物A的药理活性的影响。该通路的主要读出是苏氨酸308处的AKT的磷酸化。这种磷酸化由PDK1进行，其本身被PI3K产生的PIP3(磷脂酰肌醇3,4,5-三磷酸)激活。另外的通路读出是在Thr246处的PRAS40(富含脯氨酸的AKT1底物)的磷酸化。这种磷酸化允许mTORC1复合物的活化和p70S6K的活化，造成核糖体蛋白S6的磷酸化增强。在MCF7和T47D细胞中监测化合物A对PI3Kα的选择性抑制的影响，其已经显示依赖于用于通路活化和存活的这种同种型(Fritsch等人，MCT，10：1158/1535-7163，2014)。已经显示由于激活型热点E545K突变MCF7细胞具有PI3K通路的高基础水平的活性。
用250nM化合物A处理24小时导致先前用使MAP3K1mRNA失活的对照siRNA双链体转染的对照细胞中Thr308上的AKT磷酸化显著降低(图2A)。相反，MAP3K1的siRNA敲低导致pAKT-Thr308信号的更高的基础水平(约10倍(MCF7)和2.3倍(T47D)的增加)(图2A)。
实例2B
还使用通过采用精确的基因编辑技术(MCF7克隆CR1.4和CR2.5)产生的所选择的MAP3K1缺陷型细胞系来评估通路活性。如在使用MAP3K1的siRNA敲低之前所观察到的，该基因的失活导致MAP3K1mRNA和蛋白质的表达丧失。如前所述，MAP3K1的丧失造成Thr308上pAKT的基础水平增加。此外，使用化合物A对PI3K信号传导的抑制基于其通过蛋白印迹法评估的对Thr308上的pAKT的影响是较不明显的(图2B)。
实例3：增殖测定以确定MAP3K1缺陷型对比亲本细胞系的生长速率以及对化合物A和化合物B的敏感性。
根据实例2中描述的方案和方法，我们使用PIK3CA突变细胞系比较了MAP3K1缺失对化合物A与化合物B以及Genentech AKT抑制剂GDC-0068的敏感性的影响。
如先前描述的，在完全生长培养基中培养并用化合物A、化合物B和GDC-0068处理对照MCF7(亲本)和MAP3K1缺陷型(CR2.5)细胞系。孵育过夜后，制备细胞裂解物，并通过使用针对PI3K通路中磷酸化蛋白具有特异性的抗体的蛋白印迹法进行分析(图3)。
MAP3K1和pJNK对照印迹分别显示蛋白质表达通过基因编辑有效地被破坏并且其反映在通路的功能性失活中。pPRAS40抗体用作AKT活性的读出，并且显示MCF7CR2.5细胞系具有pPRAS40的更高的基础水平，并且此外该细胞系对化合物A、化合物B和GDC-0058抑制具有抗性。pS6RP抗体用作PI3Kα活性的远端读出，并且显示尽管化合物A、化合物B和GDC-0068可以有效地抑制亲本MCF7细胞中的pS6RP活性，但是MAP3K1缺陷型细胞(CR2.5)对所有处理具有抗性(图3)。
该数据表明MAP3K1和PIK3CA的同时突变促进对PI3Kα通路抑制剂的抗性，并且这不是特异针对AZ抑制剂(化合物A和化合物B)，但为一般抗性现象，正如用Genentech GDC-0068AKT抑制剂也观察到的。
实例4：增殖测定以确定MAP3K1缺陷型对比亲本细胞系的生长速率以及对化合物A和化合物B的敏感性。
使用经证实在MAP3K1中具有有害突变并且没有MAP3K1蛋白表达的克隆，表征单层中的生长，并且使用Incucyte技术测量常规生长培养基中单层培养物上的细胞增殖。
使用IncuCyte技术的增殖测定的方案。
将MCF7和MCF10A细胞以2000个细胞/孔的密度分别铺在含有10％FBS的RPMI培养基或含有5％HS(马血清)的DMEM/F12培养基中的96孔板中。37℃孵育16小时后，将多个浓度的化合物A、化合物B(30μM-117nM)或AZD2014(15μM-66nM)加入测定板中。然后将板放置在IncuCyte中，并安排为每6小时扫描一次，持续3天。将汇合数据的相对百分比针对对照DMSO处理的细胞进行归一化，并使用PRISM(Graphpad)拟合为非线性回归曲线。
克隆MCF7-CR1.4、MCF7-CR1.8和MCF7-CR2.5比亲本MCF7细胞增殖快两倍。类似地，克隆H1047R-CR2.3和H1047R-CR2.7比亲本MCF10AH1047R细胞的增殖更快(增殖曲线未显示)。
测试上游PI3K通路抑制剂化合物A(PI3Kα选择性，参见WO 2014/114928)和化合物B(AKT1/2变构抑制剂，参见WO 2009/047563)和mTORC1/2复合物的下游通路抑制剂(AZD2014，参见WO 2008/023161)对H1047R-CR2.3和MCF7-CR1.4的增殖的影响(图4、5和6)。尽管500nM化合物B能够抑制MCF10A-H1047R亲本细胞和MCF7亲本细胞的增殖，但它对衍生的MAP3K1突变细胞系的生长没有影响(图4和图6)。相对于MCF10A-H1047R亲本细胞，用于克隆H1047R-CR2.3的增殖的最大效应的一半所需的化合物B的浓度(IC50)增加了10倍(图5)。在MCF7细胞中，对增殖进行类似的观察。尽管500nM化合物B能够减少亲本MCF7细胞的生长，但是化合物B对MCF7-CR1.4的增殖没有影响(图4C-D和图6B)。在这种情况下，增殖的IC50增加3倍(图5)。
我们还测试了化合物A对两组细胞系的增殖的影响。我们发现与亲本系MCF10A-H1047R系相比，化合物A对克隆H1047R-CR2.3的增殖具有更高的IC50(图4A-B和图5)。与亲本MCF7细胞相比，在MCF7-CR1.4中观察到类似的影响(图4C-D和图5)。
相比之下，当比较亲本和MAP3K1突变细胞系时，未观察到mTORC1/2抑制剂AZD2014的IC50的显著变化(图5)。AZD2014在减少亲本和突变背景中的增殖同样有效。
总之，这些数据表明在PIK3CA突变背景下的MAP3K1基因失活减少了化合物A和化合物B(PI3K通路的上游组分的两种抑制剂)对癌细胞的增殖的抑制。相比之下，下游组分mTORC1/2的抑制剂对增殖的抑制不受MAP3K1失活的影响。
实例5：在3D生长培养中MAP3K1激活或耗减对PI3K通路抑制剂的影响的分析。
已知当以三维形式(3D)培养时，培养中生长的癌细胞对抑制剂显示出非常不同的敏感性。上皮细胞在细胞外基质(ECM)的影响下形成有序的极化腺体结构。附着到ECM上是控制正常上皮细胞增殖、分化和存活所需的。3D基质胶通过向上皮细胞提供适当的整合锚定来部分地概括体内人肿瘤背景。这对于可能确定细胞命运决定和药物敏感性的受体和存活蛋白的表达是必需的。最后，乳腺发育期间，在3D培养中的管腔形成和导管伸长的研究均支持在管腔间隙中失巢凋亡的关键作用(Debnath等人，Nature Reviews Cancer[自然癌症综述]，5：675-688，2005)。由于已报道MAP3K1通过JNK通路的活化在应激反应(包括失巢凋亡)中被激活，3D生长培养应显示MAP3K1失活或耗减对细胞生长和存活的更明显的影响及其对于对PI3K通路的抑制剂的敏感性的影响。
3D基质胶培养的方案
对于3D培养，将细胞接种在可商购的生长因子减少的基质胶(Mgel)(BD生物科学(BD Biosciences)，圣地亚哥，加利福尼亚州)中，并且生长(Avivar-Valderas等人，MCB，31(17)：3616-29，2011)。在IF分析的固定之前，每3天用500nM化合物B处理腺泡，直到终点(第15天)。将3D-基质胶MCF10A腺泡结构在第15天固定，并处理以进行尺寸测量和IF显微镜分析(Avivar-Valderas等人，MCB，31(17)：3616-29，2011)。
为了进行失巢凋亡测定，收集细胞(Avivar-Valderas等人，MCB，31(17)：3616-29，2011)。在定量之后，将5.105/ml细胞在指定时间用适当的生长培养基保存在超低附着板(康宁公司(Corning))中和/或用化合物B处理。
在形态发生的15天后，通过基因编辑(MCF7CR2.)的MAP3K1抑制基本上不增加腺泡数目，然而当与对照(亲本MCF7)腺泡相比时，其显着增加腺泡体积(图7A，左图)。这可以通过细胞增殖的增加或/和细胞死亡的减少(ECM-剥夺的细胞中的失巢凋亡)来解释。为了测试后者，进行用半胱天冬酶3(caspase-3)(失巢凋亡读出)染色和共焦赤道截面以分析管腔形成(发生失巢凋亡的主隔室)。
此外，化合物B处理显著降低了对照培养(MCF7亲本)中的腺泡体积，而该作用在MAP3K1缺陷型腺泡中部分恢复(图7A，左图)。因此，尽管化合物B在MCF10A-H1047R对照腺泡中诱导阳性切割半胱天冬酶3事件的数量显著增加，但是这种增加在MAP3K1缺陷型MCF10A-H1047R腺泡中不显著(图7A，右图)。
这些数据表明MAP3K1耗减减少细胞死亡，并且减弱由PI3K通路的上游抑制剂介导的细胞凋亡的诱导。
为了确认先前表明MAP3K1抑制降低对化合物B的敏感性的2D体外数据(图3)，我们用PI3Kα通路标记pS6RP染色3D-腺泡。ECM贴壁细胞(位于外边缘)对于亲代腺泡中的pS6RP是阳性的。如预测的，MCF7-CR2.5中pS6RP阳性细胞的数量更多(图7B，灰色条)。最后，尽管化合物B处理极大的降低亲本腺泡中阳性pS6RP细胞的数量，但是这种效应在MCF7CR2.5腺泡中被恢复(图7B，黑色条)。
实例6：体内异种移植物分析以比较MAP3K1缺陷型与亲本对照细胞系的生长速率。
我们使用3D MCF7和MCF10A-H1047R培养物测定来模拟早期致癌事件。使用这种途径，我们已观察到MAP3K1耗减促进肿瘤生长体积并防止化合物B诱导的细胞凋亡。虽然这些代表了比2D体外测定更具生理性的方法，但是我们已经使用体内测定对此进行了验证。图8示出了在植入后25天和45天MCF7亲本与MCF7CR2.5的肿瘤体积的差异。然而在第45天差异不显著在第25天，MAP3K1缺陷型细胞具有比亲本更大的肿瘤，并且表明CR2.5克隆比亲本对照细胞更有效地并且更快地生长。
方法3：体内研究。
亲本MCF7和突变体MAP3K1MCF7C2.5细胞在如先前描述的完全生长培养基中生长。一旦达到80％汇合率，将培养物用胰酶消化，计数并如先前描述的进行植入(Kevin Hudson等人，MCT，10.1158/1535-7163.MCT-15-0687)。总之，将5x 106个细胞皮下植入含有0.50mg/21d雌激素颗粒植入物的SCID小鼠的侧腹中。一旦可见则每周两次测量肿瘤，并且每周称量动物体重两次，除非观察到体重减轻。当肿瘤达到约1.6cm3时或当肿瘤/动物病症指示时实验结束。
本文描述的实例阐述了PI3K通路的上游组分的基因状态与MAP3K1/MAP2K4基因的状态之间的联系。具体而言，显示MAP3K1或MAP2K4基因中的突变导致PI3K通路的上游组分的抑制剂例如PI3K-α抑制剂和AKT抑制剂的作用的降低。相比之下，在用PI3K通路的下游组分例如mTOR的抑制剂的情况下没有观察到效果。因此，对于正在考虑用PI3K通路的上游组分的抑制剂治疗的患者来说，确定其MAP3K1和MAP2K4基因的基因状态是有利的。优先选择具有野生型MAP3K1和MAP2K4基因的患者进行治疗。
<110> 阿斯利康公司
<120> 用于治疗癌症的新颖生物标记和方法
<130> 200360
<150> 62/219698
<151> 2015-09-17
<160> 20
<170> PatentIn版本3.5
<210> 1
<211> 33396
<212> DNA
<213> 智人
<400> 1
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ttagattgag tatcctgggg cgctagcgag cttggtcctg tcgggacggc ctctgagtgc 5940
tgccttggtc agcgggtgag cttgggcccc tgctctgcag ccagaggccg ccccacattc 6000
actcctgggt ctctcggcct tgctccaggt ggccacttct tgactgcttt gagtccctca 6060
tccgagcgaa gggcggacgg agtccgttgg tgggggtccg gttgcctctc ccgggagctg 6120
tgtagacttc tcatacacca gggttctgga ggcagatgga ggagcccttt cgaaaacaga 6180
gtattttttt ttaagttgtg acttaataat agtagcaaga atatgtgctt atggtaaagg 6240
caggcggcag gtacggaggc tgtgggaagt cggggtccct ccgcccccac aggcagccct 6300
gtgctggcct ggtgtatacg tttctgtgca gacgtacacc accctgtgtg agcacagatg 6360
tatttttaca catggctctg gacagctgtc tgactctgtc agcagcaggc cttggagggg 6420
ctcaggcccg tgtgggggtg gggggacatc cagaggtctt tgagtccagc cctctgcctc 6480
caggccacgc ccactcagtg tcgtcagagc cccctgtgcc tgaggcgtgc gcggctcgga 6540
gccctgccct cggagtcctg cggtgccttc ctcgagtctg gcctgctttc catcctgcta 6600
agtacttggg gcatttccct ctttgggtaa ggtgtggtct tccctgtcct ggcattagac 6660
acaaggcagt gggccttcct gccattctaa gtgtagctta agacaatcag tgcaaagcaa 6720
ccctttgtgg gtgtccagcc cttgcctcgg gaggccagaa aggtggcctg gggggagagc 6780
gtctaagctg gctgtggaaa gacccatgtt gggatccatt ccacagaggt cgtcaggggt 6840
ctctgcctgg cctggaggtc ccagagagga ccctcctccc ctcaggaagg cccatctgga 6900
agggtagcag aggactgctc acaggaagag catgcgaagt gctctttctg gggatgcctg 6960
tagttggtga tgtgggaact gggttttgag ggatgcctag gagttcatcc atcagagggg 7020
aaatgaggaa gccatgcagg atcaatggat aaagtgtgct caggtgaggg ttggctggtg 7080
ggccgctgca gggcgggggc ctgtccagtg ctcccccact tacttgctgc ctcccgactg 7140
ctgtaattat gggtctgtaa ccaccctgga ctgggtgctc ctcactgacg gacttgtctg 7200
aacctctctt tgtctccagc gcccagcact gggcctggca aaacctgaga cgcccggtac 7260
atgttggcca aatgaatgaa ccagattcag accggcaggg gcgctgtggt ttaggagggg 7320
cctggggttt ctcccaggag gtttttgggc ttgcgctgga gggctctgga ctcccgtttg 7380
cgccagtggc ctgcatcctg gtcctgtctt cctcatgttt gaatttcttt gctttcctag 7440
tctggggagc agggaggagc cctgtgccct gtcccaggat ccatgggtag gaacaccatg 7500
gacagggaga gcaaacgggg ccatctgtca ccaggggctt agggaaggcc gagccagcct 7560
gggtcaaaga agtcaaaggg gctgcctgga ggaggcagcc tgtcagctgg tgcatcaggt 7620
tagggaggct gggaaggcct tttggggatg ggggtgattt gtccaacggc tgggggaggt 7680
gggaatgggg aggtgagcaa ggcagcagct ctcagggcct ggctgttgcg ggtggtggtg 7740
gcaggggctg gaggctctaa gcctagaata aggagaggcc caggtccagg gaactgtgtt 7800
caattacatg gatttgacac ttggcagccc tgagtgtttt ggggagaggg aaggcaggcg 7860
ggcagatggg ggtcagagag cttagaggga tggcagccca cctgggaagg caggtgcggg 7920
tggagccccc aggcacgtgc agtgggtctc tggctcaccc agggcgagga gctgccctta 7980
gccaggcgtg gcctcacatt cagcttcctt tgcttctccc agaggctgtg gccaggccag 8040
ctgggctcgg ggagcgccag cctgagagga gcgcgtgagc gtcgcgggag cctcgggcac 8100
catgagcgac gtggctattg tgaaggaggg ttggctgcac aaacgaggtt agtacccgct 8160
gccagggctg ggcctgggga gggagagatg ggggtagtag ccccagggtc tgtgagtgcc 8220
tgtgccctgc tgggtgggag gggctgcctc ccctggggct cctgggctgg cctagggtga 8280
gtgtcctggg ccccatgtct tcccatggca tggagggcac ggcctcgggg aggccaggag 8340
gatgaggccc tgtgcagggc cggccatctg agtggcttcc tggtgtgggc cctggcaggc 8400
gggggagctg ctgccagcct ctctcctggc tttcctggaa ggcagcgagg acactgggct 8460
gttccagggt ctggcacgct ggcggcccag ggcactgccc aagggctcct gagggcaggg 8520
cagggctgct tggcttggcc tggtgcctgc ttcaggcctg agctttgggg gtggggggaa 8580
tccgtaccgc ctgggcacag ggcatgtttg ccttggagct gcagagctgg ctgagccaag 8640
tcccccagcc cctgtgtccc cctcctcact catttggcct tgcagcctat ggaggaggtg 8700
ctgcccgagg ggcctggcca gcagctgggt gggatgggag ctggggacat agccccaccc 8760
cttccaaccc tgtgcaggcc cttctgcctc acccaccctc cgttgctcag cggggtgcgg 8820
tggagtctgg gtggctgttt tgctcctctg tcctgctagg gtgggcttcc tgttcaggtc 8880
caggtcctct ggccaagtca ctctcttctg ccccaggcgg aatcggtccg ccctctcctg 8940
acttcttttt ccagacttgt tccctcctaa gttctagtga tctcatgcca gcagcccccc 9000
ggctttacgt acaccctcta gcagatgggt ttcacatctg gtagtgggga gaccccaaac 9060
acagctggag cagacaggga ggtgtggcaa aagtaggtgt cacaagatgg ggcattgtgg 9120
gatgtatagg agctcacaga agagcaggcc taaggagcca caggagcctg ggggtggggt 9180
gaaggagtga ccgagatgag atgctggggg aatcaggggt gtggctggct gtgtgtttgg 9240
agtgtttgag tgggcagcta ccagtgatgg cacgcggggc ctcgagatga agacaaggag 9300
gctgcagacg cctgtggtcc ttggggagct tctggctctg cttcccccca aggcctcctg 9360
ccgcatcctg ccttctccat cccctccccg tgtgctgtcc cctgcttgtt ccccaggagt 9420
cctgccacct gtgcctggag gtcctctcct cacctcacag ccctctttgg tgtcagggac 9480
cccctgcccc gaccctggcc ctgttcctct ctgtgtcaca tagtctgctg cctggggccg 9540
ctgcttcttt atccttggca aatgtgtgtt tgttgataga ctgttggatc tcgggctgac 9600
ccaggagatg ccagggcctt gactgcccag gggcccaggc cccagttact ggggcaccca 9660
tcagccagct gggcctaggc aggagtgctc ccccgaggcc aggtgatttt caggctgctg 9720
ctgatgtcgt gccttcagga ggggcctggc agggacagga catcaggccc agtggggcgt 9780
ccagagagct gagtttgaac cctggttagc cactctatcg ccatgaccct ttccaagagc 9840
aaggtcattg agctccttgg gcctcagttt ccccatctac accagggagc ggtggtggga 9900
gagagacctg gtggagtgga gaatggcttg tgggcggccc tgagttgggg tccggccagc 9960
ctcagcagcc tctgggctct gtcatctggc ccctagcctc aggccaggag agagggtcct 10020
gtacctctac ccccggctct tcctcctcca tccccagtgt agtgggcgct gaggatggga 10080
ggtggcgtgg atatgacata tgcccttggc aggcatagcc cctcttgttg ccgagagcag 10140
gtggcgtcca cccgcatggc cggccgctcc ttgcggagga aagcctgtcc tccggggcct 10200
gccgcatttc gccactcccg tccctggggt cccctgtgtg tcttgcagat gtgctgtgcc 10260
accctcctgg cagggccagc cccacccgca acactggtta gaggtactag ctgccttcct 10320
gtccctagca gggctgtgct gggctgaccc cacccgtgct tcacagtgct caggcctggc 10380
tgggggtggg gagggaggga gggacgcagt gactgtcctc caggcccggc cgcagcccct 10440
tgcagacgcc ctgttccact cccccccagc cttgctcctg caggtcaggg tgcttgtctc 10500
agaggctggc ccgcacctgt cccctttgcc gggactcccc acgaccgtgg cctggggcac 10560
tttggttctc agctgaatcc ccaggtgaca gtcccaccac ggctacttgg gctggccaca 10620
cgtggcgtga tggtgccttc aggggtgatg tggtcattga gatgagaggg gacgggtatg 10680
ccctgtgtgt gaggggtggg gtggcagtgt ctgcaggctc cttctcctgc tccttgggag 10740
gtgagcgtca tctctgggaa gtggcccagg ctgctttctg ttgttctgat gtgtgtgctc 10800
tgagtcagag gagcttcagg gacagaaggg accgggcatg gggacacagg agttccggct 10860
gcaggcctgt gtggacctgt ggctggaccc aggcgaggcc tctgggtctg cacatctaac 10920
agggagatgg ttcctggagg gtgagcttag gctgttaagg gcaggagcta gtgaggaggc 10980
tggtggggcc tatagggaca gggggccaga tgtcccctcc tgtttcggct gtctcactgg 11040
ataagcagcc cagctcagct ctggccattg gtggtctggt gggctcagtg ttgctcagac 11100
gtttgcattt tcaaagattt gttctgttgt gtgaagtctc ctgatttttg aaggctgaca 11160
attttaaaaa atcaatcctg ggccagggcg caggtctggc tgaactcggc ctccagcctg 11220
cagttttcct tcctttgata gctccgtgcc aggctttggc cagaggctgt gtggctcttt 11280
tgaggtactt tccccaaaca gcttgctcac cttgcccgct tgccccagta ctcctggggc 11340
cgtgcaccag cctggctgca gcctagcccc gtggagagct gccctggtgc agccccggcc 11400
tggagcctgt ttttgtccac tcgcggctgt cttcctgagc gtccccccgt ccacatggct 11460
ggaccaagtg ggtcaggaga gggccgaggc gggtggccgg gatgctggga cccaggatga 11520
ggtgctctgg gctctcgaga aagggctggg cctaggccag gagtgggtgc cggccgcagg 11580
ggcaccacct ggactccctc aggctggtcg ctgtccgaga ggggccgggg aagagctgca 11640
ggcctggctg ccttcggcag gctgtgaccc agcaggccaa ggccgagtgg gcgggggtcg 11700
agggaagctg cctggggcgc gtgggttacg cggcagacgc tcctgagtgt gtgggcagcg 11760
tgtccaagcc acggatctgg gtgcctggcc gggcccgggt gacacgggac cgtgtgtcca 11820
tgcggctcac ggagggtcca gtctccggac atctgagtcc ttgccatgcc ctaccccggg 11880
cccatgcctg gcatagaccc cccagtccag gcctcagggc agccccctca ccactcctgc 11940
tgagttagcc ccaggcgtcc cggtggggag tatggaggct ggtctctgac cccaagcagg 12000
tgcctaggct gggcctcctt cccaccccct ctccccgcct tgaagtcctg gcactggctg 12060
tccctgcggg ggggcactga ggcagggaga gagtggttcc taccccagtg tgttacttcg 12120
ctttggtgag cgacatagaa cctcactgca tccccagctg ctgctcagcc atccagctgg 12180
tcctggggtc cctgcgtgag gtgggggacc tcagagggta caggccactc cccttcatcc 12240
tggaggaggc cttggctttg ctgagtaaac acccttgaga agaggtctgt gggggactct 12300
gagcccactc cagagagcag ctgctgcgga gggccccgca gggctaattg tttgtgtgca 12360
gatggaggct gctcattacc ccgccaggat gaggggccca gcaggaccct gagggaggga 12420
gcccgcagac tctcccctca gcctgtggga acctttgggc tccaggccag ggctgcctgt 12480
gcctcctggg cctcagtttt tcccaggctg tcaggtgagg gtcaacccca ggctgcgtct 12540
aggtggcttc agtgtgagac ccgcgggccc tgggctggtt agtgccaagc tctgcctccc 12600
ctgggggagc gttgagggtc tggaacggcc cccgtgggca ggccagggac agagatgggg 12660
aggcaagtgt gctggctcct ggtgggaggg ctgggcagag agtgggggtc ccaacagccc 12720
tgggcctacc cgggagaggg gcaggaggca caggctggtg gaggtcatgg catggctgtg 12780
gtggaggccg ccagcatcag ggaggttcct gttttgggag cttgttgagt tctcacttca 12840
aaaacaacaa aagaggaagc cgaggtggcc ttgagtgggg gtgaggggtc actgctggcc 12900
ccagccctgg accttagccc ccacgcctgg tggctcctga gtggacagct cttcttcctg 12960
tgtgtttctt ggtcactggc cctctctggg cagggatgcc ctgtgggggg ctggactccg 13020
ggaagggaaa ctgaggccca ggagagtgga cagaatgtgg gtggaatgat tcctgtgctg 13080
gggcctagac ccccgtacac cttccactct caggagaagc ctggccgggt tgcatcaggc 13140
cgggttccta gaagtcctgc acgaggctga gcggagggaa ctggcgcggc ccccgctggc 13200
gtcccctctg cctgggcaca cccggcccgg cttggggcca gcaccctgcc ctcgggccct 13260
cccatagctg agactggtgg ctgtggctgt ggctctgggc ctgctcccca ggccaccctg 13320
ggtgggcagc tgcctgctgc ttctgtctgc ttggaccatt gtgcctagtc ccatggcctc 13380
aggagaaggt tcccccagcc cagcgctggg gccccgggca ggttggcaga gggccctggg 13440
gctccaggcc aggatggggc tgttaggcga accctaggcc ccttacttcc tcatctccaa 13500
cgggagttcc cttccctgcc atgccgcctt taggtgtgtt ttccttgaac cttaaggaat 13560
gataggtttg gatttcagaa acgttggaat tgagggggtt gggagttcat gggtgactct 13620
gctgccaatg ttgcgggctt tggggtggga tccttggggc gctgtgtttg ggctcacaca 13680
ccccccaggc gggcccggtg actgcagacc ccacccatac cctgtaacct ggcgggccca 13740
cctgcccagg ccctcagctg gttgtccagc tcaggggtgg agacaccccc tgggcaggcc 13800
tggcggggag gtggctgctc cctgggcctg gagaatgcag agaggccctt cggctggcca 13860
gggtctggct ggcctcccca cagactgggg ccaggggcac agcagccagg tgtagggcgc 13920
ggagacgctg agctgcacaa gcttggtgag gtgtggggtg aggccacggg ggtcagggcc 13980
acaatgtccc agcaggccgg gggatcagaa ggagcaccct ccacagctgg ccgtgctctg 14040
ggggccctcc tgccccaggc gtggctccaa gttggggcag aaacaagatg gtggggagat 14100
ggaaggcccc tctgtggcgg gtgcttccca tggtcggtgt ggaggacgag gtccctactg 14160
cctggttcca gttcccccag caatgcaggg cacttttcct ggggtgtcag ggattgagag 14220
gccagcactg gagcccttca accgccaggg gccctgccca agagagacgg gaggagggag 14280
gggctgtggg catggctgcg tgcccccggc cgagccccgg aaggagcctg tgcccgtgcc 14340
cacttccttt cccgagggca gtgtctacac gtgggacact gtggccagcc ctccctcgca 14400
gcaggcactg tgtgctgtcc ccatgcccag cttcctccca cgcagggagc gagggtgagg 14460
gccctgggaa cccactgggt ggagggcact tggcaaagcc tgctgcaagt tatggggaga 14520
gtgggcgggg gcagagtagg aggcgccagg gaggggctgc agcctcatct gcaggggtcc 14580
tgagtaggca gggtgggcca tgacatgggt ggggcttgtt tggggcagac caaaaatgag 14640
gtgggggaca gggacaggga cagggtcttg ggatgtgctg ggctctgcga tggatgggtg 14700
tgtggcaggt ggggtgcctt tgccggcccg aggggtgggt gacgggcagt gcctgtgggg 14760
gaggacatcc aggcccaggt ggtctgtcag gggcagcacc agggaggccc agtaccccac 14820
ccagtagagc cccaggagaa tggaaagctg agacccaggt gcttccctgg agtggcagga 14880
agagaggccc cagcgcctcc ggctgtgcct cagcgaggtg gacggggtca tggtggtgcc 14940
gcctgcccgc accatgttcc tcccggggtg tgtgtgtcgg gctgaggcct gctccatggt 15000
ggagcggaag gaggtgaaga atttgcagtt tgtgtcaagt tacaacccct gccttggcgg 15060
caggacctgg ggtctctctg gtcatgatct gcctctgagg gtcacctccc ctaagtctcc 15120
gttttcccag ggagctgatg ggcatgatga gccctgcccg ccctgcctgc ctggtgggct 15180
ttctgggaga gcagaatggg tcctgggctg ggcgaggccc aggcaggtgg agcgccagtc 15240
ctctgcctgg cgggaacaga cacctctcct tgtgcagact ggccacttgt gccccctcag 15300
aagggcttgt gccgggagga gcagtggatg tatttcaccc acagacctgg gggctccagc 15360
caagtggggt cagctggcct ccgttgtgtg gcccctcccc tgcccccacc ccagcctggt 15420
tgtttacagg gttcgagggc tgctggtaaa ggggtgtgta ctcccgggcc cgggcagagg 15480
cctggcaggc cgggcccttc gcggtgagct gtgcggtctc ctggcaggcg gggagggtgg 15540
gttgcgggcc cctcatgggc tgccgtcagc ggagccgtct gctcaatgtg ctggagaagg 15600
taaatgggcc cccggcagct gtcggggcga tggatgtgtc ggcagtgggg accacggtgg 15660
ccgctgtcag ctggcgcccg ctcccagggc ctgctgggct cactttgctg tggagaagca 15720
gctcggtgcc gcctggcacc ctgccagccg ctgccaccac cgtctctgcg aagtgtttat 15780
ccagcagttt cctgagaact ggggactttg agagaatgtt cagggagctg aggacgtggt 15840
ggcctagggg ggctgacaca cctggtggct caggaggtgg tcagtcccgg gacgtggagg 15900
gccaccagct ggccctcagg ggcccaccca gtcctgccca tggcgcgtgg gtcctggccc 15960
ccatgtctaa gtgggtgccg ctttgggggg cctgacccac agtgtggcct gggacacgtg 16020
tgtgaggcgt ggagagggtg ggctgcctgt gactgtccat gtggtccccg tggtggtggt 16080
ggggtgggtt gggggaggcc aggcaggagc agcttcctct cagaaccccg gtatttggtc 16140
caggaggact tctgggaagg aaccctcttt ccctgggggt gctccagccc cttcctgggg 16200
atgagcgggg ttggggatgg aaggtcactc ctgccggagg gccacccggg acatcgggat 16260
gccagaggga ccagggctgg ggttgtgtgg ggcccaggag gtgcaggagg agtcgaggga 16320
gcctggtctc cgctgtcccc ccgggcaggg acaggagtct ggccaactgc ctacccccca 16380
ccgagggcag ccacctccca tgcctggagc cctgggccat ggatgtgctg gctggtgggg 16440
agggttacgg gtttcatcag gcacaggagc ccctgccctt gtggcttcac aggacctggt 16500
cttggatagg tgcagtgtca cagggttaag ggtcagggtg gctcccacct ggcccagggc 16560
tggccttgag agaaccctga agggtgggac cggagctgct gcctcccact gcccaggggg 16620
ccagcaggag ggtgagactg gaactgctgc ttccccgctg ccgagggaac cggccatggg 16680
gcaggagggt gggaccggag ctgctgcttc ccccttgccc aggggaccag ccatggggca 16740
ggaaggtggg accagtcccc agtgccgtcc tccactcggc cccccactca ggtcttctgg 16800
cagtggtgtg gggtccccca tccggacttg ctgacatttc tgaaggggca cctagccgtc 16860
ttccctgcca gaccctgagg cccaggccgg ggttgcactg ggaccctgcc tgctccaggt 16920
cccgggtctg aaacatgtgc agcgggtggg gacttggggg ttcttgagcc cagcatgggg 16980
gtgtgagagt tagggactga agaggccccc tgggcctgaa tgctgggcgg tctccattgc 17040
ccttgggagt ggctgctggc aggagatgac tctggctgtg tgtggggtgg ggcgtgccct 17100
ggcctcccca tttgttgcct gcctgtaccc gtctggagtg agggcctggc gtggcaacct 17160
gggggtctgt gcccactctg tgtttggtgc cctcagctgt gcaggcaggt gggtggggtg 17220
gtgttggggg ggtgactggg gtggggtggg gggatgccag ctggctgatg gtggggagat 17280
ggaaggcccc tctgtggcgg gtgcttccca tggtcggtgt ggaggacgag gtccctactg 17340
cctggttcca gttcccccag caatgcaggg cacttttcct ggggtgtcag ggattgagag 17400
gccactcttc aagtggactg tactcctgcc tcgagtgggg ggcatctgag gaccacaaca 17460
gggtggggaa ctcaagttaa gtcctggatg acaggttcca gttcccctgg ggaccctcag 17520
gatagtgaag gagaagactc catgtgggtt ggtctctttg tgtgaggggt ctgggagggc 17580
agccctggct gatgtgtctg tgctcccacc ctcctgaggg acccggagta ggcaggtgca 17640
ggcctgcagg cgtcctgtgg ccatgaggac agtgatgctg ggccccgggt ggctgtctcc 17700
tccacctgcc ccgtcctgtg tcaccccagt cctggatcag ggagtagtgg ggccctgccg 17760
catctgctgt cggggctggc cgcccaccca gcatcctgtc tgggctgaac tcgttaagat 17820
gcgcgccacg gccctggctg cagctggcac ccccccaagt gatcctctag ctgaccctct 17880
aggcgagaga tgaagaaaga gaactgtgtg tctctggacc ccttaccccg ggtccctggg 17940
gatcctgctc ctcccctgga ggggtctgtg tgctgggctg ggatgccgaa gacaaaggcc 18000
acgtgaggcc ccttcactca cacccgtctc ctggggtagg ccctgatcgc cgtctgttcc 18060
ctgggtctgt ggggccaggc gaggggaagg cactgaaagc ccagggccca tttgggcctc 18120
tgcccatccc aggactcccc aggaatgctc ggggctgggc acctgtcctc tcccaccccc 18180
cacgcctggt aagcgccgcc cctgggcctg cccctcccgc acccccagat ccagctccca 18240
gaacccccca gatgcagctc acagaacctg gggctgggct tgtggcagca gggtcagggg 18300
caaggctggg gttgggcacg ggagctgcgt gctcgggggc agcacggggc catgctgggc 18360
acggtggggg ctggcagcag ttggtggata agatgggttt caggggtgcc gggcctgggc 18420
gctcatcagt cttcccgctc agttagcgtc ccggggagtg gcagctggca ggatgggagg 18480
cactccatca ggggccgaca gctccagact ggcatgcagg cgggtgggcg tgagcagcgg 18540
ggtggcccag gatgggggac gggtggggtg ggctgcatgc agccccctga gcctgctctg 18600
ctctcactga gcgcccctgc ctgcccgctg cacctgcagg ggccctgtgg ctgggggagg 18660
ggacgtggga ggcggggtgg agctgcgtgg cacgtatgtg cgtgtatgtg cacactcggg 18720
ggtgtgcgag atcccaggtc agggacagga gccggcaccc aagggtggca ggaccacgcc 18780
tgctcggcag cccactggca ggggcatgga gggcttgcgg agtgggtggg gtctcctgat 18840
gagtgctctt gggcacaggg gcagattctg ggccctggat catcctccct gcaactgggt 18900
gttggccgtc ctccagaggt gtcaggcagc tatgagtggg ctgtggctgt ccccttcctg 18960
gtccacccca gacctgacaa cagcctcttc ccacactcag gccctgctgg gtggggtgtc 19020
cccaccctcc accagcatcc ccccagcagc cctggcttgg gcagagagag ggctggtctt 19080
gtggagacca cgccccgtgg tgctggtggg aagggcattg ggcagctggg gccggggtag 19140
gagggagagg tcacctggcc ggggggtggc catgtgtcga gccttggtgg ctcacctcta 19200
ttaaagaact cccccgtggc tccctggaaa gtagaatgcc tgctgggatg cccatgaccc 19260
atgtcctctg agctcccctg gggctgctgc cctgctggga cttccctgtg caccagggag 19320
ggctggacgc gtctgggctc accacgaaga cccagcagga ctgggtggtg ggtggtctgg 19380
tgatgggaca attgcttgtc ccccacatcc ctccaggtgt ccctgtctgg ggctcagtgt 19440
ggcatgaaaa cccaggcccc agagctcagg gaccccaacc ccttaccctg gccccctccc 19500
taacccctgc ccagtgaccc ctcagatgaa gcagttgcct aattagtaag ttccctgttg 19560
ttcaaactcc ttgcttggca aaatgtaagt ggaacatttt tttccgagtg tcagtatgaa 19620
aaatggtact tgctgggcta tcaccgagga cagctgctct gattctgaag tgtgaacgcc 19680
tgcgtacggc tgatgctgca aaacttgagg gagaatgttc ccgtgtacct gaatgaccca 19740
cgggtgggac gcggcagggc cgacggcggc agggcctgag tgtgggtctc agcctgggga 19800
cttggcaccc tctgtgccct ggggcccctg cccagctggc tgggccacct ccgtgtctgg 19860
cttcatcggc agtccccaag acggtgctcc aggcccctag acagggagtg cgatcccacg 19920
gcagtgggca gtcctgtccc gcgagcccgg ccctcagtct gagtggtgct gacctctaac 19980
tgtggacgcc atgctccatc ctcctggtgg gtggcggcgg ggcggggggg gcggccatgc 20040
tgggcagccc acacaagcca ctgtcacctg ctgtcgccac ctggccgacc ctggttgatt 20100
ggggaatgct gtcagccccg cagcccctgt ggccatagct ggggcccgag ctgctgctgg 20160
tgcctgctgg ggactggctg gtttagggct gcctcctcca ggaaggctgt gcagactggc 20220
ccagacctct tcccagcctc ctgtccatgg tactccatcc cctgcgtcca gctggcccag 20280
cccgttttca gacacagctc ggggtggctc ttctgagagg ggcgctgtgg tggggcgagt 20340
ctgccttccc gttgacccag ggccgtttct gtcgctggcc ctaagaaaca gctcccgtac 20400
cgcgcctgcc ccctgggact caggcatccc aggcacatct gtcctggcac acccagttcc 20460
tgcctggctg cctggcgagg gtctgacggg tagagtgtgc gtggctctca ccacccgcac 20520
gtctgtaggg gagtacatca agacctggcg gccacgctac ttcctcctca agaatgatgg 20580
caccttcatt ggctacaagg agcggccgca ggatgtggac caacgtgagg ctcccctcaa 20640
caacttctct gtggcgcgta agtatcccct tggcctctcg ggattcagat ttggggggtt 20700
ggctggagcc ctctttgccc accaggcccc acgatggggg tcccctggag cctccaagtc 20760
ctgggctggc aagcaacaag cactggctgg gtgggggtct ctgggccgag tcccgaggct 20820
ggctgggcag gggtctccgg gctgagtccc aaagctgagg ctggctgggt gggagtctcc 20880
aggctgagtc ctaaggccga ggctggctgg gcaggggtct ctggtccaag tcccgaggcc 20940
gaggctggct gggcaggggt ctccgagctg agtcctgagg ctggctgggc gggggtctct 21000
ggtccgagtc ccgaggccga ggctggctgg gccggggtct ctgggctgag tcccgaggcc 21060
gaggccggct gggcaggggt ttctgggcag agtcctgagg ccgaggctgg ctgggcgggg 21120
gtctctgggc cgagtcccaa ggctggctga ccctggagca gttccctggt gcccatgctc 21180
tggaagctgg agggtccgga caagtggcag cagagcccag tctcagggtg gacagctgcc 21240
ccgggggccc ctcctccaag ggggttagat agagcccatc agggcctctc cttgggaaac 21300
cccttgggtg agggggcaag agtccattgg ggtctccagc tctgaagcct ccatcactcg 21360
aggaagagct cgtgcctctc cctgcacagg ctctcagcct ccagacccca tggcagagcc 21420
tttgcttccc ctctgtgagg ctgcctcctt gcccatggag gggcaggtgc agaaaggcca 21480
gcgggggacc ttggccggag catcccacag agatgagaga catgtgacgc tccctgctcc 21540
gccctgctgt ggctttattc cttacctgta gcgggggcag gtgcgaccct acccatgtca 21600
gacgggaacc ctggcatgga gacccaggcg ccctgctagg tgggaggctg gggacacgtg 21660
ggcctcccag catggtcccc attttctgtg tccctgtcct ggagcccagc tctgcctgtg 21720
gcagccagag acacgggttg ggcatgcagg tgtgactgag tggctaatta gggcccagtt 21780
gtgggccatc tgtatgtggc agggctgggt aactgcaggc ctctgggatc tgtctcaggc 21840
aggtctgtgg tgcagagcga ggtgcccacc aggggctggc cttaggttcc atccccatgt 21900
gctgcatcgg cccctcccct ccaagtagct ctgccctcct ttctttgagg cctgcggtcc 21960
tccgactccc ttgaacttgc tggaccccca ggttctggtc cagggtctgg gaggaggtta 22020
aatgcaggga atccgtcccc aggctgggca gggaaggact cccacccttg gtgcctgcac 22080
gtataagggg aggtggggtc agtctggcac cctggctgct aggtggtctg tggccagcaa 22140
accgtgccct gaagcttcta gttgggaggg gcagaggcct tgccctgcaa agccccaggc 22200
tgaggggctg gggttggggt ggggtttacc aggacctggt tcctgtaagc cgaggtctcc 22260
ttccctggct cttccagcct caagccagca gtagcagggc agcctgatag agtagggcac 22320
cccaggggtg aggggagacc aggaaggcag acacccctgt ctcctgacag cctcgtaacc 22380
atgcaggaga ctcactgtga cttgtcccac accctcccca gtgtctcctc ggttggggct 22440
gggggcttca gggatcaggg agaggctggg tgccagcagc gtgcctggtg gcacctggga 22500
cagggccttg ctgggggtgg gtgctgtggg tgtgctcgcc aggccgaggc attgggaagg 22560
aacgaggtgg ggagctctct ggagaggcac acgggtgggt accagctgga ggtgttgcct 22620
gagcagctgg caaggctggg gccttcagat taggccatag gtgagtggcc tggagcgcct 22680
ggccaaggag cagagctggg caggggccag gggctgtgct gggcctctgt ccggggcttt 22740
tctccgggga acggttccgg ggcagtgggc tcgagactct ggccctgggg attgcatact 22800
ggggcagatc ggaccatcca ggagcgagtg ggaggtgggt gtgccggggc ttcacaccgg 22860
tttccacttc tctggcctgt gttgacacag gccaccctcc ccaccaggct ggtcccgagc 22920
cccctcctgg cccccaggcc tggaagacag cttccttgct gcctggccag gcccccttgt 22980
ggttgccagg gcctcgatgc tggaatgtca gaggcccccc actggcccct cagcctcctc 23040
ctgctttgca caggctgggc cagagcctgc cacggagccc cagcggctac acactccact 23100
cactcacacc tctcagggcc ccgcacgttc ccacagccct cagggtgtac gtgctgtagg 23160
tgtggctgtg ccccaggtat gtgttcccca ggtgtgcttg tgccccaggt gtggctgtgc 23220
cccaggtgtg cgtgtgcccc aggtgttcgt gtgccccaga tgtggctagg tgtctagatg 23280
tgttctagat gtctgtgtat tccagtgtgg ctgtgtccca ggtgtgcgtg tgccccaggt 23340
gtgtgcctca ggtgtgcgtg tgccccaggt gtggctttgc ctccagtgtg tgtgtgcccc 23400
agatgtatgt gtgccccagg tgtggctgtg ccccaggtgt gcctgtgccc caggtgtggc 23460
tgtgccccag gtgtgcctgt gccccaggtg tgggtgtgcc ccaggtgtgg gtgtgctcca 23520
ggtggctgta tttcccaggt actcagggtg aggttgggaa aaaagcagga catttctaca 23580
ctaggtggga caagcaggtt tctggggtgc ccccctcatg ccagcccctc tgtgggatct 23640
ccatacccct catcctctga ggcctggcgc acggcggggc tcagagactg aaggaaggac 23700
tgtaggagtg gacgatggtg ggggtttgac ctgacgccgg gccagatgcc ctgtgtggct 23760
gcctcagcct ggagtagagt gtctgagctg gaacaggggt cctagcccca ctctgtgagg 23820
cgagaaactg aggcttggag agaggaagag atggggcttc ccaggacctg gtgggtggta 23880
tgcaagggga gctggctggt gcagcggggg ctgtggtgag ggccctggga ggggcagggg 23940
gatgcacgca gacagaggct ctgcctgccc gcagagtgcc agctgatgaa gacggagcgg 24000
ccccggccca acaccttcat catccgctgc ctgcagtgga ccactgtcat cgaacgcacc 24060
ttccatgtgg agactcctga ggagcggtac gtgggctgtg gcggccaggc caggcacttg 24120
ggcagcccca gcgcttagga gggacacggg gatggcgggg tgctggcacc tctgcctgta 24180
gccatcctca ctccccagtg ctcccaggcc ctcctcagag cccagtttgg aaactggccc 24240
agtcctgcct gtggggtttg ggtggggaaa ctgaggctgg agataaaaac tggctaggga 24300
ccgggtgcag tggctcacgt ctataatctc ggcactttgg gaggccgagg tgcgcagatc 24360
acttgagacc aggagtttga gactagcctg ccaacatggt gaaacccccg tctctactaa 24420
aaatataaaa cttagctggg tgtggtggtg cacacctgta atcccggcta cttgggaggc 24480
tgaggcacaa gaatcgcttg aacccgagag gcagaggctg caggagccga gattttacca 24540
ctgcactcca gccagggcga tagagcaaga ctccgtctca aaaaaagaaa aacccggtgg 24600
agagggccag tcctccttgg ggggcggagt cctgcttggg aggcggagtc ctgcttgggg 24660
ggggcggagt cctgctgggg ggcggagtcc tgctgggggt tggagtccgg ttgtggggac 24720
agagtcctgc tggggggcta agcctgggtg tcccccacgt ccaagagggc ttcgtgaccc 24780
tgagtgtatg tggccagacc aggtcaagtg gtggcctcct cagggctgtc tctgggaacc 24840
ccgacagctg tggaaccacg cttgtgaggc tggcgggtgg gtgaaagacg tggggtggag 24900
ctcctgatct ggtacaggcc tgcagcctca cctgacctcc tgcagggagg agtggacaac 24960
cgccatccag actgtggctg acggcctcaa gaagcaggag gaggaggaga tggacttccg 25020
gtcgggctca cccagtgaca actcaggggc tgaagagatg gaggtgtccc tggccaagcc 25080
caagcaccgc gtggtgaggc ctgtccccac ttctgcctgt gcctggggct gccttggact 25140
gtggagggct gggtgggtca tggggtccca gctcggccca ggagacactc agcactccac 25200
ggcatctcca cctaggccgg ttttccatgt agggcgcagc tgcttcccag gtgggtcctc 25260
ttccccatgt cagaggaaaa ctggggttgc tgagccctgc caggcttggg caatgttacc 25320
ccacccttcc ctgaacccca tgctctgagc tggggccgca gccatgtgtt ccctgtaagc 25380
ctggactccc cgctgagccc agtaggccac caggtgtgaa gtggacgcct ctcctggctc 25440
tgcctccgac tctggggccc ctcatgccac cccacgcatg ccgaccagct gggcactgtt 25500
ggcagcgccg cttgctgacc ctggtgcctg cccatagacc atgaacgagt ttgagtacct 25560
gaagctgctg ggcaagggca ctttcggcaa ggtgatcctg gtgaaggaga aggccacagg 25620
ccgctactac gccatgaaga tcctcaagaa ggaagtcatc gtggccaagg tggggccggg 25680
gcggtggggc agggtggaga tgagggtgcg gggtggcagc tcacccagcc ctgctttaca 25740
ggacgaggtg gcccacacac tcaccgagaa ccgcgtcctg cagaactcca ggcacccctt 25800
cctcacagtg agtgggagcc cagatggggc tgaagggctg gggccaggta gcgactcctg 25860
gggctgtctc taggggacga tgtcctgtct tcttgggcac gtgagggctt tacacaccgt 25920
ggactccgcc gctggtgaga caggcctgcc ctggagggtc aggctgtgga ggtgcccagt 25980
gtgggctagg ggctgtgctc gctgctcccg tgtgcgggca ggtgggtggg gcaggtggcc 26040
ctggtcttcc ttgcactctg ccgaggctcc aggaggcccc agctccccat gccctgcagc 26100
cctgcctgcc aggcttttgt tgaggcccgg gctctgtcct gcagaacctg ttctggggac 26160
ttggcccagg aggtatttac tgtgaagggg gccagggtcc agccacttgg ttagttccag 26220
gtcactgtgt ttggggacga ttctcctgca gatggggcct ttgctttaaa agcacagtcg 26280
cctgtggtgg aaggcgggag ggtgggtctc gcctgggagg gtgtgtcctc cctttgcgaa 26340
ggccctggtg ctgggagcac tgtcccctgc tgaggtccca actcaccctg gaggacctga 26400
gcccaggcca ccttgctcac ctttcaaaca ctccttggca cctcaggggc tgccggggcc 26460
cagcctgatg gtggcgtggc atgaggcagt gtggtgtggg gcagtgtggt gtggggcagc 26520
gtggcatggg ggcagtgtga tgtgggggtg tatggtgtgg ggcagtgtga tggggtgtgt 26580
ggtgtggggc agtgtggtat cgggcggtgt ggtatcaggc agcgtggtgt cgggcagtgt 26640
ggtgtggggc tacgggcggt gtggtatcag gcgacgtggt atcaagcagc gtggtgtcgg 26700
gcagcgtggt gcggggctgc cgtcctgcct gtggggccgc agttccagct ccccttcctt 26760
gcaggccctg aagtactctt tccagaccca cgaccgcctc tgctttgtca tggagtacgc 26820
caacgggggc gaggtagggg ctggggctgc gggggatgga cttcgcggcc tgtgggccgc 26880
ccatggtggg gccggtcctt cccggagcct cggctactct ccatggcacc agacggtgct 26940
ccctgctggg tgggtggtgt gatgcctgcc caggcagctg cctgctgtgg ggtgacttgt 27000
tcctgctgag ttagggcttc tgagactttc caggcccccg tgccctctgg tggctggtcc 27060
cttccctgtg caatgccgag acccggtctg agaaacccca gccctgcagg ccatgggggc 27120
agaggcccga gccacggctg tgcctcaggt tgcgcctccc gcagctgttc ttccacctgt 27180
cccgggagcg tgtgttctcc gaggaccggg cccgcttcta tggcgctgag attgtgtcag 27240
ccctggacta cctgcactcg gagaagaacg tggtgtaccg ggacctcaag gtgcgctggc 27300
gggcaggcag gggggcaggg ccctgggggc ctggcggcac tgacctgagg ccacctttcc 27360
cctagctgga gaacctcatg ctggacaagg acgggcacat taagatcaca gacttcgggc 27420
tgtgcaagga ggggatcaag gacggtgcca ccatgaagac cttttgcggc acacctgagt 27480
acctggcccc cgaggtgtgc gccccacctg cgtgcatacg cgttgctgcg tccccacgtc 27540
ctgagcacac gcaatgctgt gtcctctctg tgccccaagc acgtcacacc tcccccggca 27600
gtgtcccgga caccccttga tgccgagtcc tgcccatctg ccacccgtgc aggtgctgga 27660
ggacaatgac tacggccgtg cagtggactg gtgggggctg ggcgtggtca tgtacgagat 27720
gatgtgcggt cgcctgccct tctacaacca ggaccatgag aagctttttg agctcatcct 27780
catggaggag atccgcttcc cgcgcacgct tggtcccgag gccaagtcct tgctttcagg 27840
gctgctcaag aaggacccca agcagaggtg agggccgccc atcccagcta caggctacac 27900
ctccatcccc tcatccccag gctgcacctg cccctgcgcc aggcggtcct ggcacctccc 27960
agactacact gatagccaaa gcttgatgtc cttggccagg gctgatctcc aaagcctcag 28020
gcccaagcag agtggcgggc aggccggggt cagttgggcc tctgtcccca accctgcagc 28080
ctgcacccac ccactcagga agcccctgcc ctgccgtgag ctctgtggtg ctttgctacc 28140
cacagctgct cagggacgct gcaccaccgg ctcccctccc tggccccgga acgtcctgtc 28200
tggcgggccc tacatcacag gaggaagggg cctgaaccca gggcctgggc aggtggcggt 28260
accgacactg tggccttgtt tcctgcctgc aggcttggcg ggggctccga ggacgccaag 28320
gagatcatgc agcatcgctt ctttgccggt atcgtgtggc agcacgtgta cgagaagaag 28380
gtgcggctgc tccccgcata ttcacgcgca cgcatgctcc ccacatatcc acactcacgc 28440
atgcacgtgg cacgctcgcc agatttccca cacactcgcc ctcacctcag gagcctgctg 28500
cagtcctggt acaaggaggg ccttgctgca ccaacctcag cgcctggtgc tcagaggctc 28560
tggcactgcc gggttccacc aggaaactgg cctggtcctc atttcctcct cccctcggag 28620
gtgtgtcaca ctctgagttt cctcctcccc tcggaggtgt gtcacactct gagtgccagc 28680
cttggggttc ccttccctga cgctgtgcag tgaaggctgg ctggtggtgg accaggggtg 28740
ctgccccttg gcctccacga gttcctcctg tttgacctca atcccttctg ccgcaaggag 28800
agcccagccc tatttctggc tgtgcaggga cagggacagc acctactttt ctggcacatg 28860
ggggagtccg ccctggaggg aggcagctct ttctgcatga gtcgccatcc tgggtgctca 28920
tctttcaggg accctaggag ccctggccat caccccagct gatggggtct gccagctggg 28980
ttcggaagcc tgcactctga gatgctgggt gccctgtcac caggtgtgct tctgccccgt 29040
tcccagcctg cccctcccct gaatgcctgt cctaggctgt gtgcagctgg tcgggctggg 29100
cagccctggg acccagctgg gcacctgttc tcccattaac acagggtgcc ctggtcctgg 29160
tccccgttcc tgccttgagg cctgccaccc tcctgccctg ccctccaagg gtatgggggg 29220
cctgggcagt gctcaacctc tgcccagcct tgaccagaga ccttgctaat tgacaatgga 29280
caatgctggt gcccagccca gactctgggg tggggcagtg cttgaggggg tccttgactg 29340
tgggacctga ggggctctct ggcagctcct cacgtgtgca catcacctta tagtcaccct 29400
tcatcctggg tcattgagag tcctgtctgc agccagatgc cagcaggctg tggtcctgta 29460
gtccctgagc catggaggca gggtgggctc atcctgtgca ccttgttcca cagtctccct 29520
ctttcccaat ttacaagaag accaataaga aaaataagaa aacaagaaag aaaaaggaaa 29580
aataaagtta tcacctcctg gtagcaggga gggtctctca gagctgggct gcactacctc 29640
ctgtcgcctg ctggggctgc tgtgagggca gctttgcgtc tcagctgttg agggttgtct 29700
ccgtgctcct gcacccctca tgtccctccc tcccagagct gcctctgtgg ggggctggtg 29760
gcttgctgct ctctgacatc agtcctgcct ggagacccct tggagatcca ggtgctttga 29820
aggtcttgag cacacttgag ggtgtgctgg gagtggggag cgaagctcat gactgtcccg 29880
tctgcccacc tctgcagctc agcccaccct tcaagcccca ggtcacgtcg gagactgaca 29940
ccaggtattt tgatgaggag ttcacggccc agatgatcac catcacacca cctgaccaag 30000
gtgaggggcc actgcctgcc cccgcccact cccttttctc tccacactca gagaggcctg 30060
cagtgttcag cttttttggc ttcagatgtt ttaaaatcta aatatttaaa aaggttcctt 30120
ttggagagtg ccaatgatca gggtgggagg cagtgctctg agggcccagg tccctgtgtc 30180
aatctgtggg gccctgtctc agtttcctgg cagtatggca gcgtgctggc cgtgctttaa 30240
gaggttggct tcctactgga gctgtgggtg ggtggaggtg gcagggaggt ggggcaccgg 30300
ggtctgagct gtctacaccc acagatgaca gcatggagtg tgtggacagc gagcgcaggc 30360
cccacttccc ccagttctcc tactcggcca gcggcacggc ctgaggcggc ggtggactgc 30420
gctggacgat agcttggagg gatggagagg cggcctcgtg ccatgatctg tatttaatgg 30480
tttttatttc tcgggtgcat ttgagagaag ccacgctgtc ctctcgagcc cagatggaaa 30540
gacgtttttg tgctgtgggc agcaccctcc cccgcagcgg ggtagggaag aaaactatcc 30600
tgcgggtttt aatttatttc atccagtttg ttctccgggt gtggcctcag ccctcagaac 30660
aatccgattc acgtagggaa atgttaagga cttctgcagc tatgcgcaat gtggcattgg 30720
ggggccgggc aggtcctgcc catgtgtccc ctcactctgt cagccagccg ccctgggctg 30780
tctgtcacca gctatctgtc atctctctgg ggccctgggc ctcagttcaa cctggtggca 30840
ccagatgcaa cctcactatg gtatgctggc cagcaccctc tcctgggggt ggcaggcaca 30900
cagcagcccc ccagcactaa ggccgtgtct ctgaggacgt catcggaggc tgggcccctg 30960
ggatgggacc agggatgggg gatgggccag ggtttaccca gtgggacaga ggagcaaggt 31020
ttaaatttgt tattgtgtat tatgttgttc aaatgcattt tgggggtttt taatctttgt 31080
gacaggaaag ccctccccct tccccttctg tgtcacagtt cttggtgact gtcccaccgg 31140
gagcctcccc ctcagatgat ctctccacgg tagcacttga ccttttcgac gcttaacctt 31200
tccgctgtcg ccccaggccc tccctgactc cctgtggggg tggccatccc tgggcccctc 31260
cacgcctcct ggccagacgc tgccgctgcc gctgcaccac ggcgtttttt tacaacattc 31320
aactttagta tttttactat tataatataa tatggaacct tccctccaaa ttcttcaata 31380
aaagttgctt ttcaaatttt tggctcactt tgctgggtgg aagagtgggt ggccagggag 31440
ggagtgggga gtcctgggag ggaagcagca tcctcagagc agctggtcct ccccagctcc 31500
tcctggtggg caccgccacc ccaacaggtt tggggacagg ctgtgtggtg ggccgaggcg 31560
ggagtataca ggcctgttcc caggggcagc ctcccatgga aggtgttcca cccccatctc 31620
cagaggcctg gcctgagggg agatgggagg ccctggctgg ccctgccccc gttgggatcc 31680
acctcttctt cccttgaccc cacccagctt caccccagcc atgaaggaga ccattggacc 31740
acgtggccat ctgcccccca gccccaggtg ctgttcccct gggtagggca gtgaatgaga 31800
cagaccacca ggaaggacag atagggcagg gcccagagtt ggggccaagg tcatggcctg 31860
ggccacggtg gaagtaaggc tgggaggcct gagtggcctg ttcgaagctg gacagagcgg 31920
gaggaggggc tgcaggcggt gggaggaggg gctgcagggg gcgggagggg acaggctggg 31980
gcccaggtta ccccagagca ctacatcgag ctctgagccg gaacagcctg cagaatgtgc 32040
cggtgctgcc acctggtgga cgcctgccgg aaccgcgccc tgagccagga gaggagtcca 32100
ctgccgagca actgacagcg ggttggcgac caggttccgg gtggttgggt gaccagcacg 32160
agccaggggc ctggagcttc agcttcctca tctctcaaat ggactccccg taggtgtgga 32220
tggttgcaga gtcaggcccc tggcgatggc aattggcccc tctctaaggc attcccaggg 32280
gtgcgtggct gccctcactt ccactggagg gggtgcccca tagggagcac aggctggcga 32340
ggatgttctg ggtctgtggg agccaagaac agccacatct ggagcagccc gaagctctcc 32400
tctgggtgat cccttattgc ttcagttcta acaggccgca aaactgatac cgcttttcgg 32460
gaaatacacg aaacatgaca cagtaaatga tgttccgagg gtgagaggca tctggatttc 32520
agatctatca ataatgtgac tcttagaaac caaaaaatac agcaatgccc ttccaatatc 32580
cacaaacttt gagcaaagca ttgctgaaag taaccaaggt atggaaatgg tcaggcagac 32640
gcagcatctc ccagacagcc cggctgagaa gcatgggctg cttctcccag cacggccccc 32700
tctgacaata taggattgcc ttagggccat ttcttacctt ttttatggta gagatagggt 32760
ctcgctatgt tgttcaggcc ggtcttgaac tccgggcctc aagtgatcct cctgccttgt 32820
cctcccaaaa cgttgggatt ataaggtgtg agccaccaca cctggcctct tagggatagt 32880
tctatagtcc agagagagag aggcttcaac gtcattggca ttaatacaga catgaccctg 32940
tgttatgtcc ccgttacaag tggctgagga cctaacaaaa tgaacgcaga aatggagacc 33000
ctctgagaat ttcccgaccc tcctagcagc cccagacaga accatctaca gcaggaggca 33060
gcatcccagg agtggggtgg agggtgtcag tgaggggtga gatgtgcaag gagatgcaca 33120
tctcagagag gaaactccag gaggtgcagg tgcccttgca aggggcagtc cagtcctggc 33180
cagcgaggcc agagcgggtg gagagggcca ggatcctgca gccccaacag ggcctgccga 33240
acagcgaggg ctgtctggag aggttgtaac aggaatacgc caaccaagag gaagctctcc 33300
ttcctgtgtc agaggtaccc cgaaggaaac aatgcataaa gtgtccattt ccaagacaaa 33360
gtgcctaaaa tcagcttagg tcagcaaact acggaa 33396
<210> 2
<211> 62042
<212> DNA
<213> 智人
<400> 2
tttgtagatt ctggctcggg aatcaaatac atgattttgg catttcttta taatgtggga 60
aactctttta aatattttat ttatttattt atttatttat ttatttattt tttgagctag 120
agtctcgctc tgtcacccag gctggagtgc agtggcacag tctcggctca ctgcaacctc 180
tgcctcctgg gttcaagtga ttctcatgcc tccgcctccc agtagctggg attacaggtg 240
cctgccacct cccgggctaa tttttgtatt tttagtagag acggggtttc gccatgttgg 300
ccaggctggt ctctaactcc tggcctcaag tgatcctcct gcctcggcct cccaaagtgc 360
tgggattaca ggtgtgagac actgtgtcca gcctaatatt ttaaataaaa aataaaaatg 420
gggccgggta cggtggctca cgcctataat cccagcactt tgggaggctg aggtgggcgg 480
atcacgaggt caggagattg agaccatcct ggctaacatg gtgaaacctt gtctctacta 540
aaaatacaaa aatcagccgg gcatggttgt gggtgccagt aatcccagct actcgggagg 600
ctgaggcaga agaatcactt gaacccagga ggtggaggtt gcagtgagcc gagatcgcac 660
cactgcactc cagcctggtg actgagagag actccatctc aaaaaaaaaa attattttgt 720
gactagtccc cacagcttgt ccagttgcca tcgataagga gactcctctg tgagaagcct 780
tggaatggac tcctgggcct gatttctact ccctgggcac agaagggggc tttgaggaga 840
tgtcctctcc aacccttggg gcaagatccc tcatcgtttt cttttttctg aatcaagaga 900
cctttgaaca gctttcaata agttaccggc cccctctacc cagcaaagtg catgtgcagt 960
ccatacttat agttatgggg agagagttta tagactagat taagatggaa gaaaatgggg 1020
tgaggttgta gggaattttc ttctggttca cacttttttt ctttcttttt tttttttttt 1080
tgagatagag ttttgctctt gttgacaagg ctggagtgca atggtgccac ctccgctcac 1140
tgcaacctcc acctcccggg ttcaaggaat tctcctgcct cagtctccca agtggctggg 1200
attataggcg cctgccacca cgcccggcta aatttttgta tttttagtag aaatggggtc 1260
tcaccatgtt ggccaggctg ttctcgaact cctgacctca ggtgatccac ctgcctctgc 1320
ctcccaaagt gctgggatta caggtgtgag ccaccatgcc cagtcgcctc gatcgatcac 1380
ccttgatgct gaaatggaaa gggtctcgct gtgttgccct gccacaagat tcaaagtggc 1440
cctcaagttt cacccttgat gctgaaaata gagaaagagt ctcgctatgt tgcccaggat 1500
ggcctttgag gccccccaaa gataactaag ccatttgcag aagtaacata gggcacaaaa 1560
gtagggccaa tacttttcca ttttctagca tgagttgagt taagagcaca ggctctggta 1620
tcaaactgtc tgggttcaaa tactgtcttt gtccttaact tgtcctggga actcaagcaa 1680
ggcccttaat gtgctgttac atttaacctc cagggttact gtgtagatag caacaggata 1740
gcatcagtgg gagtgtgttt acacagaact tggcctgtaa caattgctaa ataaattata 1800
ttattactgt cttaatagaa taaagaaagg caagctcaga gaagtgaagt gactttgaca 1860
aggacacaga aaagatacga ttagaacctg ggcctactca tcatcaatgc taaaaagtgt 1920
tgtttacctc ctagactaat gttttacaaa ctacaaggca caaccagaaa atcagttcag 1980
cagggttgcg gaattgaaat aaatagtata ttaagggctg ggcgtggtgg ctcatgtctg 2040
taatcccagc actttgagag gccaaggtgg gcagatcacc tgaggtcagg agttcgagac 2100
cagcctgacc aacatggaga aacaccatct ctactaaaaa tacaaaatta gccaggcgtg 2160
gtggtgcatg cctgtaatac cagctacttg ggaggctgag gcaggagaat cgcttgaacc 2220
caggaggcgg aggttgtggt gagccgagat cgtgctattg tactccagcc tgggcaacaa 2280
gaacaaaact cagactcaaa aataaataaa taaataaaaa tacaaaaatt agccaggtgt 2340
ggtggtgcac gcctgtaatc cctctactca ggaggctgag gcaggagaat cacttgaacc 2400
taggaggcgg aggtttcagt gagccgagat ggcggatggc accactgcac tccagcctgg 2460
gagacagagt gagactgtgt caaaaaaaaa aaaaaaaaaa aagaatatta ggccaagtgc 2520
ggtggctcac atctctaatc ccagttcttt gggaggctaa ggtgggtgga tcgcctcagc 2580
tcaggagtct gagaccagtc tgggcaacat ggcgaaactc cgtctctacc aaaaatacaa 2640
aaaaattagc tgggcatagt ggcgcacatc tgtggtccca gtacttggga ggccgaagtg 2700
ggaggatcgc ttgagcatgg gaggtgtcgg ttgcagtgaa ctgagattgt gccactgcat 2760
ttcaacctcg gtgacggagg gggtgaaacc ctgtctcaaa aaaacaataa aaaaccaaaa 2820
ccagaaagag ccgggtgcag tggctcacac ctgttatccc ggcactttgg gaggccaagg 2880
caggtggatc acgaggtcaa gagatggaga ctatcctggc caacatggtg aaaccccctc 2940
tctactaaaa atacaaaaaa attagctggg cgtgttggcg cgtgcctgta atcccagcta 3000
ctcaggaggc cgaggcagga gaatcgcttg aacctgggag gcagagggca gaggttgcag 3060
tgagccaaga tctcgccact gcactccagc ctggcgatgc agtgagtctc aaaaaaaaaa 3120
aaaaaaaaaa agagaaagcc actgcccttg actaccagtg ctgcaaggag tttatacaca 3180
agcacatggg tggtttcagt gagatctcag tgtgtcataa ttaagtgccc taggaggggc 3240
taggattcaa gttggcccag gggagactta gacgtagggg aatggcctgt gagctgttca 3300
gtgtggacag gagtgaagag ggttggtcac agtaaccttg agtctagatt agggcagaag 3360
ggctaatgct tgaaacaaac attctgcaag agcccactct gggcaatgtt ggatacacac 3420
tgatctctga gacagtcttg gtctcttcct ttactgtgtt tcctgtgcag tgggggaaac 3480
agacctgtca ccagacagta atagatgaaa atggttaggg ctgtgaaggg ggaggcattg 3540
gtcagagtta ttaacaccga ctgatgggga agaccgggaa ttaggaatac caagcagcaa 3600
gttccaagct agaaaccaaa taagaaaggg ctagttccag cattaggttt acgtctcaga 3660
aaacgaaagc cgaaccctca gcaggatttg cctgaaacac tctcacagac tgaggtggac 3720
ccaggattca actctcagtc aggcattttt ctcacttacc aatgcataca attgccaagt 3780
tatatggcat actggaaccc aaattcagga ggcagcacaa tcccctatga gagaggaggg 3840
gctgggagcc agatgtctca cagctgtcca gtatactagc taatatacgg attaggatct 3900
gtgcaaagct cttttcttgc agggtcattt tttttctttt ttctttcttt tctttttttt 3960
tttttttttt gagacggaga cttgcactgt cgcccgggcc ggagtgcaat ggcatgatct 4020
cggctcactg aaacctctgc ctcccgggtt cacgcgattc tcctgcctca agcctcccaa 4080
gtagttggga ttacaggcac acaccgacat gcccggcttt tttttttttt tttgtatttt 4140
gagtagagac ggggtttcac tatgttggcc aggctgtctc gaactcctga cctcatgatc 4200
cgtctgcctt ggcctcccca agtgctagga ttacaggagt gagccaccgc gcccggccgc 4260
agggtgattt taaggccttt atgggcccaa gttgcattat aaaatgttat atcccagatt 4320
cactggaata tgtacgatga gagcaggtgg cattaatatc ttgcagtaat gaactaattg 4380
gtaaaaaccg ttttgtttac attaaaatgg ttcaaaagcc agcgacacag cgatgattgt 4440
ttccatttag cagatgtgga tactgaggca cagaaaacgg tcaagccttc tgcccacagt 4500
caccagaaag gaggaaattc aagtctgggg ttgtgtggct tcagagcctg agctcaacca 4560
tgacgagcac actgaaaagg aaacccctcc taactaactc ccgctccggg gtcctttaag 4620
agcgtcagaa cccagaactg agtaaaacaa gatcaaagcg tatgtaaata cggactaggg 4680
gctgccggga aataatcact acggctaggc cctagggaaa gcagacgtcg gagtcctagt 4740
gcgcctgcgt agccccatct cgcctttccg ccccacggcc tagcgaggcc catctctaac 4800
ccacacaggc ccaaagttgt ctaatgtgcg caggcgccct gctgtgagcc cgcctccttc 4860
tctgccctgc tcttgcgctc tcgctctctc agagttcgtc tctggctctt tgtacgtcac 4920
ttcctgtttg tggcgcgaga gggcggtatt tccgtccaga gggtgggagg gggcggtaag 4980
cgggggctgg ggggaggggg cggggggggc cgcgccgtgc tagccgttgg gcctgcctcg 5040
gaggaggcgt cgccgccgcc gctgccgctg ccggcgccgt tgccgctgcc gggaaacaca 5100
aggaaaggga accagcgcag cgtggcgatg ggcgggggta gagccccgcc ggagaggctg 5160
ggcggctgcc ggtgacaggt gagtgcgcca gcgcgtgtcc ccgaacgccc cccccacgat 5220
ggtcgcgtcc gggccccccg cggtgccgcg atgggctgta ccacccgtgc ccggcggggg 5280
gaccgcggcc ctcgagcccc tccttcagga gctgagtggg ggtggccgag cgggggcggt 5340
gggaccagcc tcggggggcc ggggcggtgg cggcgggcca taccactgag gcggtggggg 5400
gagcgctgca agtttgcggg acggggagcg caggccgcag cgtgcgcggg ccgggggctg 5460
gacctttcgg gcgcggcggg cagatcgagc ctggcgtgcg cgggctaagc tatcgagggg 5520
gcgcgccgca tcaagtgtag agggctgtac ctttttggcg ctgtggaagc cgttgctgtg 5580
ctgtatttac aggggtgggg gcttctgggg aggatgcttc cccaactgtg gctgggttat 5640
atcaccacgg cgttggggga gccctgctta gaacgtaggg gaacccaaat cagaggactg 5700
tgatgtttgt gatctttaag ggactgggac ggggcgggac aggccctagt gggttttagg 5760
ggcgtatttt gggaggactg tgatgccgat tggtgaggag gggtttctgt ttcctgtatt 5820
tgacgtgtgt ggcgttgggg gtttacactg atctcagcct ttattgaact tcttaacgac 5880
tctggaggga acgtcatggt tactggggtg ctttggacca tggaggtgct gctctggatt 5940
ccattaccct ctcagattat ttaccaggca gtaacagttc tttccttcca taggggaggg 6000
aggaaagctg tgttagaagt cactgaagtt gtctgagcct taacattctg aagaggaaga 6060
gggattgggc ttggatttga ggagccgtgc ccctgcaccc gcttgttaaa acttgggagg 6120
aaggagtgtt tgggggaaca cctcttcccc ccagggaagc tctctggggg catcttgatc 6180
ttgggattgt gaggacctct tcctctcatt tggagacctc ttggggctca gcaagacgcc 6240
tgggctggag taactagagc ctccaatggg ctgcttttca acttcatcca ctcctacctt 6300
cccagagaag cagcaggagt tcactcgtgg gctgaacttg gttggcagtg gatgtgaagg 6360
gtccaggaac caacgcagac cactacatgc tcctctgtcg ctggccacga agctgtttgt 6420
gtctcccagt taccagctcg gtcacacatc atgtttacac tccccaccaa ggcagtaaca 6480
gttggccttg cagtgaggcc gggagctgtt ttcccagctg ttcctctttg cataggccaa 6540
ggggacttgg agtgggggtg cccctggccc agcctggccc agggaggaag gctgctctga 6600
agggcttggg acagtcagat cccccatgga tctggtgtct tattgtggtc tgtgggctgg 6660
tgctgggagc agccagcccc agaggtctgt ggccagtgtc cctgctccct aggccagatc 6720
atgaccttgg cttgccctgt agcctttgct ctgggtctgg agttcccaga ggactggctg 6780
cagtccctga ttgacccagc agacctgggc tggtgatgtg gtcagagggg gcagatggtt 6840
gcccctagtc cgcagcagtg acttccaagc tgactggctt ccgtggctcg tggttcctgg 6900
agagaaaggt cccacagtct gtgaggcagc ggcgactctg tagaatcttt ctccactagg 6960
ggtttgttcc tctggtcctc tcctgccagc ttttagaggg tttgcctgat ggggctaaca 7020
gtggcagtga aaacagtaat catgaaattg atggctgaca gtaactgagt gcattctgtg 7080
ggccacacac tgtttggaat gcttcatata gataaacttg ctgaatactt gaattctaga 7140
gcggtaggcg ctgttgttat gctctccctt ttagatgaga aaacagcatc tcagagaggc 7200
agatcatttc cagagctagt ggatgcccag tgtttatagc attcacccca tgccaggcgt 7260
gtgacagggc ttttgtacat gtgatctcac ttaagtctca aaacatacct gtggttaggc 7320
ctattttatg gagagctacg agctagttag aagtgtgata ccattttaca gatgaggaat 7380
catttcactc actgtgaagt gcaaagattt cccagaggtc tcatagctga agtgggagag 7440
gtgtgatgtg agcccttggc caaccttggc ctcagatcgt cttgtcaagg agaaactgga 7500
ggagtggctt ttgtctgtga gcatatactc tgcccagccc tgtgctttgg gctttatatg 7560
gtatttgtgt ccttttttgc agagtccgaa attgaagttc agaggaagaa ttgccttcca 7620
ccgcatctta tcagacccta tgggtgccag ggtaggattt gaacccaggt cactgagccc 7680
ctagtgccat gcattccttg ctcaccaggt tccaggctgg gtgaaaggaa ggaaagacat 7740
aggatagagt cacctctgtc ctctgtcctc tacctataga ggtgactgtc ctatgtcttt 7800
ccttcctctt acccctgagc ctcaggctgc cctgagcatc tctgcctaca gccagtccag 7860
catttcttgg tccctcctca gagtggaggc aaggcatcct ttaaccctgg gcaggtgtgt 7920
gctgggagaa gaagacagca agagagccat gcagggggtg acacagctac cagggacctg 7980
cgttagctag cagcaggacg gtgaagtcgg ttctagctct gcgaccttgg accacactgt 8040
tcactcccat acagtggtct cagaaggacg tccaccttgg gctgttgtga ggattaaatg 8100
aattaatcca cgagaagctc ctagaatggt gcctggtact gtgtaagtct tggttggcag 8160
tcatgattat gttatggaac ggaggcatcc agcctccccc accccctact tttggtcccc 8220
tcgagcattc cgggatccag ctccccagcc tggcccagct aggatccaga acttcaatgt 8280
tctggtttcc agcctctgta aagaggtgta tggaagcgag tgagagcaca gggttcaaat 8340
ccagccgtgc cactccatgg ctgtgtgacc ttgagcaggc tccccaaccc ttgtgagctc 8400
atttcatcat cggtgccatg gggatgatga taattcccac ctgataggat tattgtgaag 8460
gctgagtgga ttaatttgtg ggaagcattc ataactgttc tggcatacaa taagcctacc 8520
ggaaatgtct cctcactaag aacagtgccc gacacatggt gagctgttgg tctgtcttag 8580
caattgtaat tcttagtatt tctgccggga ctttgaaggc ctttgccagt tcacagaacc 8640
gtgtcagaga gcactaggag gagatcaggg ctgaaattag catctcagtt ttacagatgc 8700
agaaacagag gtcgggggag acatgcaatc aagtcagaac tgacaagggc agctcccggg 8760
cccactcctc ttccacgcag tggctttgca gccctgagcg cctccaaggt agacacactg 8820
gagtcttttc agaggtcagg ctctgtgctt gttttttttt ttcttttgag acagggcctc 8880
cctctgtcac ccaggctgga gtgcagtggt gtgatcacag ctcactgcag gcttgacctc 8940
ctaggcttta gtgatccttc cacctcatcc tcttgagtag ctgggactac aggtgcatgc 9000
caccatgcct agctaatttt taaatttttt gtggaaacgg gagtctcgct atgttgctca 9060
ggctagtctt gaactcctgg gctcaagtga tcctcctgcc tcagtctcct gagtagctgg 9120
gaccgtaggt gcatgccact gcccctggtt cccagcccac cacagctcac agctctggga 9180
gtggcaggaa ggctgggcct gggcaggggg agcagcagaa gtgcctgcag gggttggcag 9240
gggctgtgct gcactggcct gtgggcctgg gtgagaggtg aggatggatc ctaagggtat 9300
tgtggagccg aggaaaaggt ttcactcatc cgccaccatt tactgaacac ctcgtatgtg 9360
ccagcgttgc atcagtactg ggaatacagc agtgtacttg ccaaagtccc tatccttgtg 9420
gggctaagca agaccaaccc gaaacaggtt aataagcaag gagccggtta gagggggagg 9480
agctaggcag cgaattcaaa tcaggtgaca gactgggcac ttctttagat gcatgcggct 9540
gtggggaggg cctctgagct gatcccagtt tggcaaggtg aggcagtcat gtgggatggg 9600
aggagaagga acagccctcc aggtggaggg aaccacagtg caaaggtctg aagggaggac 9660
agagcttggt gaggtgcagg gacaagcctc acggaggcct gtgtggcttg gcagagcgag 9720
ggagcaggga ggagatgagt cctggggctg cggggcaggc agggcccttt cactgggagc 9780
cttgtggact gtctgtgaag gagtttggaa tttcagcagg aacagcctgg tcagattcag 9840
ggtgttagca ggtgacccag gagccggtca caggctcctg cctgggggcg tgggtagatt 9900
tgactgagcg gagcagggcg tttcacaggc ctcccacttc ccctccagta gcatcactgc 9960
cttacagcca gcaaaggcct gagggttgcc tccctcctgt ggttttcaca ccgtgttctc 10020
cagagcccgt ggctgttact tttagggaaa gaggagggga ggctcattgg gctgatttct 10080
ctgcccattc ctccccaacc caaccagccg gactaatact gaatagcaac gcagggcagc 10140
agtcacacct gatacagaca gcacccgctg accctgcgtc cacgctgccg tgggcctgta 10200
ggcctgcgcc attcccagtg ctcctctgga attggaaaga ccagggcttg tgactggcgc 10260
ccagcaccca ggtctctggt tgggctcagg tgtggttgat attacgaagg caaaataaat 10320
gagggccagg ttgagagtgt gggcatgttt ctccactata gctgggtgat cagggaggac 10380
ctccctgagg aggtgacgtg tgggtaggga ctggagtgct gtgagggagc catgggagga 10440
tctgggtgaa gacccattag acccaggagg aatcttctct gattcccgct ttacaagtgg 10500
tgagaactga agcctggaga gcctctgtag cttgtgctga gtcccccaac caggaagtgt 10560
tggggacagg ctatgaatct gggcttccag agattccccc accacagctc agtagcccct 10620
ggtgagtgtg acttctgatc ccacccatgg gctcacccct aaggcttggt gcgggagcag 10680
gcgctctggc tttttttttt ttttttgagg tgtgttccag ggtatcttcc tagaaggagc 10740
agaacccctc agaacaaacc actagggtct ccagaaggcc cccgggatgg gttgggatgg 10800
aaaggagtgt ctttcagact tgagctccaa gcccctggag gacccagggt cacccctccc 10860
cgggcctctc ttcagcttcc cagagctctc agcggaaggc cctcaaccac aggcctccgg 10920
gccgcacggt ggggtggttc catggcaggc tcttctggac agccagccaa gcagcgagag 10980
gcccagctgg gggagacagc ctgggagcag gaccaggagg gagggagtga gtgtgggagg 11040
ggcgctgggt gggagctcag cctggccccc ttggggcagg acccactgcc aactcggcac 11100
ccacagcagg gcccaggtgc tctgactgtg ccgagcgagg gacagcaagc cgggtcggcc 11160
aagaggagac tgcatgtcag aggtcccagc aggagtttct tcagcccagc cgtcctgctg 11220
gagaagctcg ttcgcagatg ttgtttctaa gggtgaggcc agaaacccaa gtcttcctcg 11280
gtttgccact ttgtgggccc tttccgaatg ggctggggca gttgccgctc cccggttctc 11340
ttctccagcc tggcttcaag ttcttcatgg tctggtgggt ttttggtgta cacttaccca 11400
gctggggctg ctgagtgacc tggtcccggg ggtagctgac gtgggtgaga accctgctct 11460
tggcacccct ctcggtggct gtggagctct ggggccttat ttcttctccc taaggtgcat 11520
tttgctcagc tgtaaacggg aaccttcctg ctgagtgggg cggtggggag gatgcacgga 11580
gctgctgcgt tggaaagcac aggcctcctg aggaggcggc gggatgaatt tgggctgatg 11640
ctactcctgg tgattgccag acaggactga gggcacctga gagcacagaa ggggctctgc 11700
agggcagtgg gcacaggctc gttgttggtc cttgggagag agtggtaggg cctgttagct 11760
gatgggaggg ctccagacag gaatgtgaat cactcccacc actgtactcc tgcccaacca 11820
gacgctgcat attagctcta caaacctgca cagcagcctg ggaggtgggc agtgttagca 11880
ctcccatctc gtagatagga aactgaggcc caggaagcca catagaatat tggggtcatt 11940
ctcgtgagta gttcgcctct cagtgctggg cactgctgca gagcttaagg tgtctgctct 12000
cactcatcct caccacagcc tggcagctcg ctgtcccgat cgtccccgtt gtacagggga 12060
ggaaacgggc atagagaggt tattggattt gctggaagtc agtaataggc atgatggttg 12120
aaccctgctc tgtcggcgaa gctgcctttt gaagacagcc tcatcttctt gccctgcctg 12180
ctatgactgg agttgtcact gttgtcatca tgatttcttt tctgctttct cttctcctag 12240
acagagctgg cacaaagtag gcctcagtaa tccagaaatg actccattcc atgcctgctt 12300
gggatgtggg gtgtggctgc ttctctccac ccccaatacc atgaccttgg cccctcccaa 12360
ggggggccca gggggaagag atgaggatgg gaggcacccc ctccccactg ccctaggggc 12420
ctgattgctg aacagcctca ggagccagcc tttggctgtt cttggtcatt tgtgtgttcc 12480
atctgtctcc aaatattgat tgaatcactt ctatgtgcca cgtgtagttc tggatgcgat 12540
cggaggtggc agagaggttg cattggcctg tgagtgcttg gtgtggctga aggagggaac 12600
agagatctag ctggactggg tgggagaggg gcttgggaag gctgctgagg agcccctgtg 12660
atgtgagagc ccgaggaagt gggctggacg gggtgcagcc aggtaaaggc cgcaaggaag 12720
gcgatatctg gatgtgctgg tggaacagca ggcccatgta gctggagccg ggggagtggg 12780
tgagggggag agagcagggt ggcagggctc agggcctggg ctatgatggg gatccagggc 12840
tttatcccca aagagaaggg acacaggtgg gtggggaggg acctgtgtgg gagagagctg 12900
gctggattca ggtggcagcc agggatggag aaagcagacc atattctgct ttggagacag 12960
ggcgccctag agcccagctt ctcaaactgg tgtccgaagg ccttggcggg tgggaggagg 13020
tgtctgcagg gcattgactc tttttagctg tgtgttttca tttagatgat attttcaaaa 13080
agttagtagg ggcatgttgg aaattattgg gatgattcct ttagaaccaa gtagtgacag 13140
cagtaacatt agctgccact gcatggctct gacaggctca ggacggcccc tgatgtcaga 13200
gtcctttatg taattgccac ctatttttca agcactggcc ctgtccccag ctgtgtgtga 13260
agccatctca ttgggtcccc aggacaaccc atggttatca gaaaaatcat ctttttaaat 13320
ttttcattat ttttttgaga cagggtctgg ctctgtcacc caggctggaa tgcagtggca 13380
ccatcatggc tgattgcagc cttgacctca ctggctcaag tggtcctccc acctcagcct 13440
tctgagtagc tgggactaca ggcatgcacc atcatacctg gctaattttt ttaaaacaat 13500
tttcagtaga gatgggagtc tccctatttt gctcaggctg atcttgaact tttgggctcc 13560
agtgatccac atccctcagc ctcccaaagt gctgggatta caggcgtgaa tcactgcacc 13620
tggcctgcaa aaattatctt ttgagataac ataaacatgt gcttgggcag attggtgtta 13680
agattccatt ctacaggctg ggcacggtgg ttcacacctg taatcccagc actttgggag 13740
gccgaggagg gtggatcacg aggtcaggag ttcagtacca gcctggccaa gatggtgaaa 13800
ccctgtctgt actaaaaata caaaaattag ccaggtgtgg tggtgggtgc ctataatcct 13860
agctattcgg gaggttgaga caggagaatt gcttgaacct gggaagcaga ggttgcagtg 13920
agccaagatc gcactactgc actccagcct ggcgacagag tgagactctg tctcaaaaaa 13980
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagattcca ttttacagat gcggaagctg 14040
aggttcagag aagtgacctg tgtagcctgg aagtggtaga gtcaggattt gagttgacta 14100
gaggtgtgag tttgggcctg agtcctgctc caattcccca ggtaagctgc gttggggtgc 14160
gggagagatg gggtatagca tgggagcttc cagccgcact gggatgatct ggctcctctt 14220
gggcctgtga gagtcacatc cctgcctcct gcctttaagc tcccggtgct taattagcag 14280
gaattctata gaattgcact ccagaatggt agctactagc catgtatgga cttttttttt 14340
tttttttgag acggagtctt gctctgtcac ccaggctgga gtgcagtggt gtgatcttgt 14400
ctcactacaa ccgccgcctc ccgggttcaa gcgattctct gcctcagcct cccgagtagc 14460
tgggattaca ggcgcctacc accacgcctg gctaattttt gtatttttag tagagacagg 14520
gtttcaccat cttggccagg ctggtcttga actcctgacc ttgtgatcgc cccccgccca 14580
cccccccccc ccccagcctc ccaaagtgct gggattacag gcgtgagtca tcgtgcccgg 14640
actcacatat ggctttttaa gttttaatta attacaatta aagaaaagta aaaagtcagt 14700
tctttagttg cactagccat cattcaaaca tttagtaacc acatttctgt cgttatggaa 14760
aggtctgtgg gctagttctg ctctggttgc ggtccctctc ctgcacctac tcgctgtgac 14820
tgtgtgcatg tggctctctc cctgggcctc agttttccca tgtgaggaac ggggatagta 14880
acacaggctg gctgtgaaga tgaacattaa tccatgcctg gtgctttgtg agtgctcact 14940
gagtattagc cttgatgcag acccactggt ttctcctttt gccactgggc cctgccctgg 15000
agctcccagg gaggtggtgg cgatgcagag cgacgtgggt cagggattcc ccatgcagtc 15060
caactggagg gctcccgtgc atgcgtgcac atcaggggcg gtaaggaagg gctggccggg 15120
gtgtgggagg aggcgacaca agatgggagg tggccctgtc tcttgggagc aaaggcagaa 15180
ggaggtggag gcagctcagg gctcggagga gaggggtccg ggctccttgg ctgtgtccct 15240
gctgtctctc gctgtgggta ttcaccgaat ctctcccatc ctcggttttc acatctgctg 15300
catgcaggtc ctcatggttc tcaagtgagg caggtggtga gcccatcagg ccagtgccca 15360
gggcttattc tggggacagc tcctggagag gaagggctgc ctccctaagg actcctgccc 15420
tgccctgggt gcaaggggtt ccacctgctg cccctccccc actccccagc tcgcctcagg 15480
cggatagttc ccctctcact ccaaataaga gccacaatgc tgacagtggc ccccaaggcc 15540
ctgcccagcg gtccccagct tcctctagct acatctcccg gccctcccct tcacccactc 15600
ctgtaggcgc ctcgaacgcg cctcagccct gctcctcccc tgcctgcagc gttcctcccc 15660
aggtctcccc cggctctctc acctgcttcc ggttttgctc agactgcgct gcctcagtgc 15720
gcccttctgt caccatcctg tgtatagtcg gaaacccctg ctccctttcc ctgcactgaa 15780
tcttccgtgt gctccttttc tccatggcat ttgttagctt tggctatcct gtctaatttg 15840
cgtatgtatt tattttttat tttgctgcct gttccctcat tcccccaact ccccaatggc 15900
agggagttct gttttggtca ctgctgaatc cctggtgacc cgagcagtga tgatgcagag 15960
ttgttgtgat atttgtggaa tgaatgaatg caggattttt tgttttacct tcacttggca 16020
caaatgctgt ggttctgttc accactcccc cctgaagtaa tgaaagttat gggcccatcc 16080
ctgtgctgag tggagctggg gacacagtgg gggctaggac agactgtatc cctgccttgt 16140
ggaacccaca gtccagtggg agaggcgaca ttacccacat agtcatgcag gtgacagagg 16200
caagtgctgt gaggggaagg gaaggctgag ctctgagagt ccgctgctcg tgggagaggg 16260
gtggtcaggg aaggcctccg tgaagaagat gggtgaacag agtgccaggc aaggggtaca 16320
gcatgtgcaa aggtcttggg gtgtgagagc agggagtctt catggggcca ggagaagggg 16380
agattgtgtg ttggagcgag cagaccagtg aggctggaga gcaggcgggg ccaaggcaga 16440
tggcccctgg cagcctccat aggggccttg gacgtgatcc atgggcacta gggagaggtc 16500
ctgagcaggg gagggacagg gtcagaactg cgtggaggat cccgctggtt gcagcatgga 16560
gccctcagag tgtatggagc ccgtggccaa gcagactaga atatttgaca tgatttctgt 16620
gggtgctgta aggccctggg tggcgtgagg gggaaggtgt gtgtgtgggg tggcagggag 16680
gagaaggaat ctgctctgtg cttattcttg tccccgtttc ttttgcagcc tgcccacggc 16740
ttcaacctgc ctccagcccc acctgctcca agcagacaga tggggcgagt gtagggagtg 16800
tgtttaaaag aaaaaagaaa caaaaagtct ctctcttttt tttttttgaa gtacccagac 16860
cttttcagga aaaaaaaaaa aaagtttctt cagtgccacc ttctcaccaa ggaggtagaa 16920
taggtaaaaa ttcacctgtt cagaaacata cagtatagaa agtgaagttt cccatgtctc 16980
cacccatcag aggaaataat aatttttttt ttttttttga gatggagtct tgctctgtcc 17040
ctcaggctgg agtgcagtgg tgcaatctct gcttactcca acctctgcct cccgggtcca 17100
agcaattctc ctgcctcagc ctcctgagta gctggaatta caggtgcctg ccaccagccc 17160
ggctaatttt tgaattttta gtagagacag agtttcacca tattggccag gctggtctcg 17220
acctcctgac cttgtgattt gcccgcctcg gcctcccaaa gtgctgggat tacagtcatg 17280
agccaccgcg cctggccagt gatgataata tttgatacgt gttgagcagt tgctcttaca 17340
ggctcttttg ggaggacttc atgtggatta actcactgaa ccctccaata gccttagaga 17400
taggtatatg cagttattat ctctaatata cagatgagga aacagaggtg aagaaaggga 17460
acatgacttg gtgacttgcc caaggtctca cagcaggtga cacagccagg gctgaaaagc 17520
tggcatttgg ttcctgaggc tgccttgcct cccgcaccca ctctcctgcc tcttagtgtg 17580
gcgtatttcc ttcggatttc ttttttctgt gcgtgtgaca tttaaacaca tacctccccg 17640
tgccctgaag tctaagacag tatgccctat aaggtccatc attgatcata taactgcttt 17700
tctgaaaaga atgcgatagg tgagttttgt ccatggattg caaggtacat gccaatctca 17760
atgacatcag catgtgaaac aatacgcata ttgtagaatt gaggtgacag ggcgtgtgtg 17820
tgtgcgtttc agaaaaggca tcccgcctgc attctgtcgt gccgcgagcc ttcgttagcg 17880
aatgctgatg gtcccagtgt cagcacagca gggctggttt ctgtgtttct gtgctcagga 17940
tggcttgttg tgttgtgtgg ccagaccgtc tccacgtgct gggtgctgtg ctgagccctt 18000
ccctgcatta gcctgtgatg aaagcgctgc tgtctgtcct tgcaaggaca ggaggaaacg 18060
gaggcttggg agtctagaaa gtgggcaaac aaggacccca gtccagatct gcctaactct 18120
caaggctgtg tggcatggtg ttgtggggga gccaggccgc ctgtacttcc tgagatgaag 18180
tcatagggca agtcatttca cttctgtgcc tcagtttcct cattgtcata gaaacagtag 18240
gagtgtctgc ctcaaagtgt tgctgtgagg gttatattgg tatgtgcgaa gcactcaaat 18300
gggcctggca cgtggtatgg gctatgtgag ccttgctctt tttagtagag tcatgatatt 18360
aaccaatata tagcaccaga cccctgttgt gagcttttag attgttgcca ggtttcccta 18420
tttcagcagt acatacttag gacagcggtt gtcagctggt ggtggttttg taccccagga 18480
gacatttggt gatgactgaa gacatgtttg attgtcgtaa ccaggggaag gtgttctgtt 18540
ggctttagtg agtagagacc caggatgctg ccagacctct tcagggtgca gaagagtccc 18600
cacatcaggg attctctatc cccaaatgtc actagtgttg aggctgagaa ttcccagctt 18660
agaacttctg tgccctggca ctagcatttt ctgcaggaga aattcctcca agcacatgta 18720
cattttccac tttatgagtt ttaccagaat gttctcacaa gacgctggga ccagtttata 18780
gagtggtgaa tggctggtgg cagatgaggg agttggttcc ctcacgtctt gccccaggtg 18840
cctttctcct gagttcccat gagcagatgc tgcctgttac accactagtt cctgttgtct 18900
ttgggttttt tggttttttt tttttttttt ttgagacagg gtctggcttt gtcacccagg 18960
ctggagtgca gtggcacaat ctcagctcac tgcaacctct acctcccagg ctcaggtcaa 19020
cctcccacct cagcctccca ggtacctgaa actacaggtg cacaccacca cacctgacta 19080
ctatatatat atatatgtat atatacgtgt atatatacat atatatgtgt gtatatatat 19140
atatatgtat gtatgtatgt acgtatgttt tttttttttt tggcagacac agggtttcac 19200
catgttgctc aggctggtct caaactcctg ggttcagagg atcctcttgc cttggcttcc 19260
caaagtgctg agattacagg tgtgagccac cgtgcccggc cagctttttt tgtttgtttg 19320
tttgtttgtt tgtttgtctg ttttttgaga cacagttttg ctctgtctcc caggctggag 19380
tgtggtggtg tagtcatagc tcactgcagc ctcaacctcc tgggctcaag caatcctcct 19440
ggctcagcct cccaagtagc tgggactaca ggtgtgcacc accacacctg gctaattttt 19500
atattttttg tagagataag gtcttgctat gttaccaagg ctggtcttga actcctggtc 19560
ttaagagatc ctcttgcctc agccttccaa agtgctggga ttacacgcgt gagccaccac 19620
gtccagcttc ctgttgtctt tgaatttatc tcctgagcaa gtcttcctcc gggcgctgtg 19680
gaaaggcaca gatctgagtg caggcgacag aggctcctga gggggtcgct gccacctccc 19740
caatgagcct ccgcagcacc aggaaggagc cccacccacc agctccagct ccaagagacg 19800
cagatctctg cttccccacc tgcctcccta gcccatctgt gctgtctggc atcaaaatca 19860
ggtcagtgag agggggcgag agaaaaagga cttagtaagt ggcaaggaaa ggaattgagc 19920
ttattttgag cctgttctgg gcacagggct tcactctgta catgttcatt ccacagatac 19980
ttattaagta cccactccac tctgtgccca acaccctaca aagctctggg gatccagctg 20040
tggctaaggc agccaagagt cctgcctttg tcgtgctgac attccagtgt gggtggtggg 20100
ctgtcagcgt aagcaaacac atacagtaac atcggtggtg atgggtgctt aggggaaaat 20160
gaagggtaag ggtaagggga ggtagggtgg gcatgctttg cctagggagg ttaggaaggc 20220
ttctcaagaa agggacgtga gcagaggctg aagagagtgg agaggggcct gagtttccac 20280
ctgagggtgc agtgcctgca aggccctgag gtggggcgtc cccatgtatc ctggcagctg 20340
agggagccag gcactgctga agtgaagtgc cctcagagaa gcaaaggggg atgttgcagg 20400
ccgcgtaggg tcctggggct gctttgggga ttttggcttt tatgttgcat gggagggttc 20460
gagcggagaa ggggtgggag ctgactcagg tggtcacggg gctccaggct gcaggagggg 20520
cgtgggcaga gtgctgactt ctttcactct ataacattct ctcactcctt ccctgctgta 20580
ttcagcagca gtttagtcct tttcgttgct gagtagtgtt ctactgtgga tctacgtgtt 20640
tgtttattca ttctcttgtg ggtagactcc tggtctgtta ccagtttggg gttactgtga 20700
atattgctgc tgtcaacatt gtagtacaag tcttttgtac atacactaat ttccttgaga 20760
cgaattgcta ggtcgtggga taggcatata ttgagctttg attttgactg cttaacagtt 20820
ttccacagta gttgaaccat tttgcacctc ccaccaataa tgagtaaggg ttctggttcc 20880
tctacatccg agccagcagt tggccttgtc agtttttaaa attcgagcca tcccaggtag 20940
gtggttatga tttgcatttg cctgtaacta atgagattat gtatgtttct tggttgtgtg 21000
ggtgtcctct cctgtgaggt gctcttgctc tttttacctt gtcttgagtc aacagctgca 21060
gctctggccc aggcactcag aagactcatg cccaggaacc ttaggaagta atgagtgtgg 21120
tggggccgtg cagggactcc cctccgcagg gcgtgctatg ggggttccat aggcgagtct 21180
ctgtccccct gcctgagtgt cctccattgg cagccccccg agtgatcagg ccatcttttt 21240
tttttgagat gtagtttcgc tcttgttgcc caggctggag tgcaatggcg cgatcttggc 21300
tctccacaac ctccacctcc cgggttcaag cgattctcct gcctcagcct cccaagtagc 21360
atgtgccacc acgcccagct aattttctgt tttcagtgga gacaagattt ctccatattg 21420
gtcaggctgg tctcgaactc ccgacctcag gtgatccgcc cacctcagcc tcccaaagtg 21480
ctgggattac aggcgtgagc caccgtgccc ggcctaagcc agccatcttc ttggctgcag 21540
tggctggtat ttcatcacca caggactgcg tcacggacac ctcagctgag gcaccaccct 21600
cagtgggagg acagggcagg atccaggcgg gacgcagggg atcttccaac tcctccccct 21660
gctctccctc cagctgtgct gactccttag ttgctgagat gagcttgtaa aaagcagctc 21720
tgttgatccc agcagcggcc agggcctccg ctgcttctcg gctgggagac ccgaggtaaa 21780
cagcttccct tctctcagct tctgtcctca tctgggcatg gtcactgact gtctggtggg 21840
gtgttgggag cattcaggag agactccatg ggagcgccgg caccctgccc aaggccaccc 21900
agctggcggt ggctcttgga ctctggaacc cagaccactc ttggccatac ctggctgcct 21960
ttgcttctct ctggaataat ggcagccatg tgtttggctg ttcactgggc gccaggcagt 22020
aggccgagcc ctgggcccac agtgggtact ttagtgctgc tgcattacaa gggccctgag 22080
aggcgatgtc cctgggccgc tgtgggccag cgagagggga gatgagacat ggagcccctg 22140
ttctattccc tccacatcag cccctccttt ggactctgag ttctccctcc cagccatttg 22200
ggaagtattt tgaactgagc ttgcatcagg gaaggtgtgg tgtaggtccg tgtaggggac 22260
gggcttctct cagtcccagc catagcccag aaggcccttg gtgttctccc ctgtccacct 22320
ctctcgtgtt tctcctcacc aggccccctc ctgcctcagg tccttgcatt ttctgttccc 22380
ctgctgaaat acatttcctc atgtgttaca cagctcactc cctcagttaa ctcgggtgtc 22440
tgctcgcaag tcccgcacac caagctaaca tcctgttctt ccactctcca gcctccccac 22500
cacctgatta tttgcatatt cgtgtatttt tctgcccctc acaccagact gtgagcctca 22560
tgaaggcagg gctgtgtctt agtgacattc tgttgctggt accatccggg gtctaggatg 22620
caccccaaaa aagattggtg tcatgaagag agtctggtag tgtgtccctg gctgtgtgtg 22680
gtcctggggt gggggtcagt tggggacact tggcctcttt cttcatgtgc tcattagata 22740
agacgctttg ctggtctact gcattagcgt taataggtgt tgggagggtt gctccgaggg 22800
tgcacaaaga gcacacagtg cagcctctga ggtggggaag gcttcctgga ggaggcactg 22860
gtttagctga gacctcaagg aagagagaga agaacgccca gaaggaggtg ctgtccctga 22920
tggaggccag agggaagggc ttgagtgaca gaagcataac atggagagtc aggtagggcg 22980
gagaggctgg agaggtgcaa tagtcaacgt catggtcctt agcctttccc gagggctttc 23040
taggtgcacg tctcagctca tgcacctgga acgcagggca gcagaggcga ggtcctgaag 23100
ggccttggat cctcagctga ggagtttggc ttttttgctg ggaacaccag ggagccacaa 23160
aggttctgag caggagaaag acaggttcag cgttggggat ccctctagct gctgaatgtg 23220
gggtgagtgg gagggagcaa gagtggagcg taggaactcg gggaagaggt gggggcagat 23280
gggggcagac ctgactagag ccaggccgcg ggcaggatgg ggagagatgg tcacgttaga 23340
ggttgacaca cagaacagtg ggagatacag aaatacatac atatttatat attttttgag 23400
acagggtctc attctgtcac ctaagctgga gtgcagtggt gcaatcaagg ctcactgcag 23460
cctggacctc ccaggctcga gtgatcctcc tgtctcgaat agctgacatt acaggtgcac 23520
agcaccatgc ctggctaatt ttttaatttt taattttttt gtagaaaaaa attaggtcgt 23580
gagacaagtt ctcactacgt tgcccaggca ggtctcaaac tcctaggctc aagggattct 23640
cctgctttga cctcccaaag tgttgggatt acagacatga gccattgtgc ccggccgaga 23700
tgtggggatg ctgaggattg agagtctggc agtcctgtgt gcttgggttg tggggtgccg 23760
ggcatgttgc tggcaagggg agccccttat tgctgctccc agcctcgcat cattgccttt 23820
gcagcttgga gcccagaatg tgatttctca ccctcttgtt tacttccctg tcatgtccat 23880
cttgtctttc ctcccgcttc ctaccactta cctcccttct ttctgccggg acctgggcag 23940
cctgccactg tcacatgcca ggcagtagcg tgtccggccc accagctccc ctggggcacg 24000
agagaaagct gatgcccatg gtgtccctag agccagctgc cacttctctg ggcgccaccg 24060
tagctcccga cctgctgtcc gcaaataacc ccaggctggg aaaggcaaag gcgccttggt 24120
ctctgtggac cctggccagg ccccaggctc caggtagggg cccagctggc gctgcctcgc 24180
gccctcctcc cctccgttct gggaacctga gacgaagcag tggcctcggc gtccctcagt 24240
ctgttggttg ctggtccctg aggacagaag tgaaggtctt ggggtaggga tcagggcctc 24300
ggtcaagccc ccaggactgg cttctaggcc ccagaccgtg catacgcagt aggttgcttt 24360
cttgttcaag atcccggatt gtctgagacc tgtcttttct ctgtcatctg atggggggag 24420
ggaggccgct gaggctcagg gaatggcatg ggatggcatg gggggacggg agtgtgctta 24480
gtttgttgaa ggtggcaggt tggtggcttc ctggtttgga aagaagggag aggggagaga 24540
gagaaaagag tgtgtgtgtg taagatggtg gagggacagg cagatgctgg tggctctgcg 24600
cattccctca ggtaccctgg gctgcctcat tcatactggg ttacctcagt gttgggccat 24660
gggaatgaca cggggagggc agggcacggc taccttgatg cttgctcagt caggagtgac 24720
tgtgggtgga ggggccacct ccccccagca tgggtgtcct gagtttgggg tctggcctgc 24780
gcttaggccg gggagctctg cttcccccag attggggtcg ctggggacat tgccacatct 24840
ctctgctcag aatgggtcct tgagagcggg ctccacgcca cccttgctgg ccttaccctt 24900
tgctgagtgg gcagaacagc cagagggcct cagagcccgg cgtcctcagg gaaggggctg 24960
gtgtggaatc ccctcccgcc ctgaccagct cctctcttgt cttgcagact gtgccctgtc 25020
cacggtgcct cctgcatgtc ctgctgccct gagctgtccc gagctaggtg acagcgtacc 25080
acgctgccac catgaatgag gtgtctgtca tcaaagaagg ctggctccac aagcgtggta 25140
agaggccgct tttgcccgcc agattctttc tcccacgctg gctcctcctg gaaagctgtg 25200
ccctgagagg cagaggcgga gggtcttacc agcctgagga gccagcattc cgcagcccca 25260
ggcccacagc tgcttatgcc cccatttcgt ggactccttc agtggtcatc tgggcaggag 25320
agcagggatc tgactgtgca tgagtgatct cattcatagc cccattttat agatgaagaa 25380
actgaggccc agagagggga agtcacgtca ctgaactaac acagtgaggc agtattcagc 25440
attcattcag ttagcaagta ttcattgact gtgtgctgtg ccggatagcc ccgggctccg 25500
agacacagtg gtcccctgat ggagcttaca ttccagtggg ggtggggcag gcagtaaata 25560
agtagacatg gaatgtcggg gtggcaagtg ctggggtgaa aagtgggaac tgtgagtgag 25620
ggacaatggg ctgggggcgg gggggcatca agaggctgcc cggaggagac ggcagtggtc 25680
agaggcctgg agcctggagg aggtgagacg ctggctgggc aagggtgtcc cagggagagg 25740
gacagcaagg acagaggctc ccaggtgggg atgtgcctgg tgttttctgg taacagcgtg 25800
gctggagcag tgtgagctag ggcgagctgg gggaggcaag cagaggagca acgcggagtc 25860
cagctgtgtc gcgcctgcag gtcatggaaa aggaccttgg ctttggcact ccagacgaga 25920
gcagccctgt gatgtcgtga gccgatgcgt ggcctgatcc atttgtacta gtgggaagct 25980
gaggtcccct tttagtgaag ttaggacagg gaagagaccc tttttgaccc cagggctgtt 26040
tgtcccaaag tggctgccac gcaagactgg gaggcagatg gggagaagcg ccacctgctg 26100
agagatggct ttgtcccagg ccagcttctg tgggcctccc cctggaaaga aggtccccag 26160
gtgtggcggt tggctgccct gtgtgcactt gcattcattc agcaaacacg tgctgagcag 26220
cgcctgtggg ccaggcgctg ttctaggtcc tggggtccag cagtgagccc gacaggcaaa 26280
catcccatcc tcgtgttagt atcttgggcg ctgacaggga ggcagacagc tcccaggcag 26340
acatgcatgt ctcacggtgg cgcgagccat ggagaaaaaa caagcaacgt gaggatggga 26400
gggcatgagg caggcagggc ggccagaggg ggcttcgctg agaagggggc atctgaataa 26460
aggcctgaag gaaatcgggg attgagcctc acagttatgc cagaggcgac agccaatgag 26520
tcctgagggg gtaagtgggc ttgttcaaag agggggcagg aagctggcgc tgcaggcatc 26580
gggaagagcc acgcatcctg cactgtacca gcctgcagac gcagacaggg agcagcgatg 26640
agggatggac gcccctccct gggagcagcc tccccacctg actgagcaga ggagattcgt 26700
gtcctgctgc tctttctgga cagagatggc ttttaaggtc ccttggccca gtcccccagc 26760
ctgagcctgg agtctgggtt tgttgatgga gcttcctgag tcttggcagc tatcaaggtt 26820
ctaaccctgg ttctgctgct tcctcttagt gcaactgtga gcaagccatg tcacctcact 26880
gagccttggt ttcacatcta taaagtgggt taacaagcca gatctctgat gttgtcagct 26940
ctacaagggt aggcattttc atgaggcttc ttcacagtgg tatccccagc acgtctaaaa 27000
gtggtgggca tacagtaggc actcagtaaa tggttgttga atgaatggtt ggcgtggtgt 27060
gtgggtggtg tgctggggaa cacagggtca tgggctcctg tcccgtggcc tgcacgtgcg 27120
gaggccatgg ctcattaggc tggactgtga gagccttggg atgggtgtgg aactgttgga 27180
ggggcaagag tttctctctg gtctaggatt actgatggca ttaaatgagt cttggcccct 27240
cttgggcctt cagtgtccgc attcatgtta caaggggcca gatgacccag ccacaggcct 27300
gcctctgtca tctgggatgg cctagctctg acacacctgt ctcaggtttg caccctacac 27360
acacgcttgt gcacacctgc actcttgggc cttcccagtg cccatctttc tgagtagcag 27420
ctggcagagg tgggcaaggt gaggtgggcc ctgctgacta ctgctgtttt gggacctgta 27480
ccaccccacc gacccccttg gtggttaaaa taatggcagt gctggtttac tgagcactta 27540
ctgtgtgcca gacacctgtc tctgctctag gcaagcctga ttttgttgaa tttttataga 27600
tgccctgtgg agcacatgcc accttacaga ctggaaagct aaggttcagt aggaagagtg 27660
acttgcttga ggtttcagca aggagtgggt agagctgagg ttggactcag gccctctgac 27720
tcctgaacta gtgctctcaa ggcctggccc acgtgctgcc tctcacccag caagctgtgc 27780
ttaaggccaa gggtgtagta atagcacatc taatcagagt cactcatgcc atgtgctggt 27840
cccacttctg acacagctgc agcacaccac cattagcaga gcacctgccc tctgccacgc 27900
cccatgctgg gctccatctg ccggtttaga ggcagacggt atagtagtca agatgtgggc 27960
tgtgctttcc aattctggct ctcccaggta acagctggga aggttgggca aactaatagg 28020
acctctctgt gactcagttt ccccatccgc aaaataggaa tacaattgtg aggatatttt 28080
tccttctacc tgttttttgt cttttttttt ttttcataga tatatggtct tgctatattg 28140
cccaggtggg tcttgaactc ctagcctcaa gtgagtctcc tgtcttggcc tcccaaagtg 28200
ctgggattac agttgtgagc cactgcgttc agcttttagg tttcttttct tagcttgtta 28260
ccaaagtatg aaaggccaca gataaatgcc tggataataa actcgcccca atcccagtgt 28320
acagttcaag aaatagaata agacggtccc cggaagctct cccaagtgct cctcccaagc 28380
agttaccgct ctcctaacct ccagtaacac agatgaggtt ttttttagtt tttatccttt 28440
aaaaaaaaaa aaacggggat gaaatttaca taacgtgaga ttaaccattt tgaagtgtat 28500
gattcattgg cctttagtat atcacaatgt tgtgtaacca ctacctctat ctagtttcaa 28560
aaccttttca ttaccccaaa ataaaacttt gtacccatta agcagtcagt ttttgtatcc 28620
tatgtcttag ttcattctgt gctgctataa catattaccc gagactgggt aatttataat 28680
gaacagaaac ttatttctta ccgttctgga ggtagggaag tccgagattc agggttggca 28740
tcttcttgtc acacgtccca tggtgaaagg ggaagggtaa gagagaacaa gacagggctg 28800
aacttgtctt gttttttttt ttttttgaga tggagtcttg ctctgtcgcc caggctggag 28860
tgccgtggcg cgatctcggc tcactgcaac ctctgcctcc ttggttcaag gaattctcct 28920
gcttcagcct cctgagtagc tgggattaca ggcgtgtgcc accatgcttg gctaattttt 28980
gtattattag tagagatggg gtttcaccat gttggccagg ctggtcttga actcctgacc 29040
tcaggtgatc cacctgcctt ggcctcccaa agtgctggga ttacaggcgt gagccattgc 29100
gcctggccga actcgtcctt ttataaggaa cccactctgt gataatgtca ttaatccatt 29160
catgagggtg gtgctccctt cacccaaata cctcccatga ggctgcattg gggatcaagt 29220
ttccaacaca tgaactttgg gggacaattc aattcatagc accccctgtc tcctggtgtc 29280
tgctaaccac cagtttactt tctgtctcta tgaatttacc tactctggac atttcatgta 29340
aatggaatca tatgtggcct tttgtgactg gcttctttaa cttagcaaca tgattttttg 29400
ttttgagtca gggtcttggg ctatcgccca ggctgcagtg cagtggtggg accttggctc 29460
atggctcact gcagcctcaa cctcctggtc tcaagtgatc ctcctgcctc agcctccaga 29520
gtagctggga ctacaggcag gtgccaccac acttggctaa gcttaatgtt tttgaggttc 29580
ctctatgtag tagcgtatat caatatgtcg ttccttctta tggatgaata atctctatgt 29640
tgtagatgta tcacattttg ttatctgtta atttgttgat ggacattggg atgatatatt 29700
cttttttttt tttttttttt tttttttttt gagatggaat ctcactctgt caccaggctg 29760
gagtgcagtg gcgtgatctc ggctcactgc agcctccgcc tcctgggttc aagtgattct 29820
cctgcctcag cctcctgagt agctgggact acaggtgtgc gccaccatgc ctggctaatt 29880
tttatatttt tagtagagat ggggtttcac catattggcc aggatggtct ttatctcttg 29940
accttgggat ccgcccacct cggcctccca aagtgctggg attacaggcg tgagccacca 30000
agcccggcct cggggtgata tattctatat ttaacttttt gaagaagcag ctgcaccatt 30060
ttacattccc accagcagtg catgagggtg tcagtttata tccttgccaa cacttgtttt 30120
tttttcatta cagccatcct tgggcatgta aagttgtacc tcattgtgtg tgtggatttt 30180
tttgtttttg ttttgttttg tttttttgag acagagtctt gctctgtctc ccatgctgga 30240
gtgcagtggc acgatctcag ctcactgtaa cctccacctc ctgggttcac atgattctca 30300
ggcctcagcc tcccaagcac tgggactata ggcatgtgcc accacgcccg gctaattttt 30360
gtatttttag tagagatggg gtttgatcat gttggccagg ctggttttga actcctgacc 30420
tcaagtgatc cgcctgcctc gacctcccaa agtgctggga ttacaggtgt gagctaccgc 30480
gcccggcctt catcgtgatt ttgatttatg tttgccagat gactaatgat gctgaacatc 30540
ttttcatctt tctgttgacc atttgtgtat ctttggagga atatctcttt gagtcctttg 30600
ctcattttaa aatcaggcag tttgtctttt tgttgttgca ttgtaagagt tctttatgtg 30660
ttctggttaa tagaccctta ttagatttcc aagtatttcc acccattctg taggttatct 30720
ttttactttc ttgacagtgt cctttcatgc acaaaggttt ttaattttga tgagttcact 30780
tgaagttttt ctttttgttg cttgtgcatt tggtgtcatc taagaattca ttgccaaatt 30840
caaagtaatg agatttactc atgtattctt agactttttt tgtagtttta gctcttatat 30900
tcaggtcaat tcattttgag tttatttttg tatatggttt acagtgtgaa gtaggatatc 30960
acaaaagaat gtgatatcca ttcttttgaa tgtggatatc cagttgcctc agtttcttca 31020
tctgcaaaat agggataaga ttgtgaggat aggctactct gggcacattg cctatgggtc 31080
actgttccct gctctgcaag gaacagtatt taaattaaca aaaaaaattg taaggatatt 31140
ttttcttcta ggtttctttt ctttcgtttt gaaaaaatat agtctctttg ttgaagaaac 31200
tgttctttcc ccattgaatg atcttggcat ctgtgttgaa aatcagttga atgtagatat 31260
ttgggtttat tttttggctc tgaattctct tccattggtc tgtatgtctg tcctgtataa 31320
actgtactgt tttgattact atagctttgt atagtaaatt ttgaaattgg aaagtattta 31380
actttatttt tctttttcaa tattattttg gctctttggg gccctttgaa attccatgtg 31440
aatgtgagga ttggcttttc tatttctgaa aaaagaaaaa gcctgttgga attttgatag 31500
ggattgcatt gaatctgtat attgctttgg gtagtattgc catcttaaca atattgtctt 31560
ctaatccatg cacacaggat gtttttgcat ttatgtagat ctctaatttc tttaaacaat 31620
gttttgtagt atacaagccc ttcaccccct tggttaagta tttttttgga ggcttttgta 31680
aatgcttttt tttttttttt ttaagagcta gggtcttgct ctgtcactgg gctggactgc 31740
agtggcacca tcatagcttc aatttcttga gctcaggtga ttctgccatt tcggcctcct 31800
gagtagctgg gacttcaggc acacgcaacg actcctggct aattaaaaaa cattttttgt 31860
ggagaccaga tctcactatg ttgcccaggc tcgtctcaaa ctccagactt aagcctgcct 31920
cagcctccca aagtgctagg attttacagg tgggagccac tgtgctggtg tttaatagcc 31980
atgttgaggt aaaactgatg tactacatga ttcatccatt taaagcatac agttcagttg 32040
gttttagtat gttcagagtt gtgcatccat caccatactc aggttttttt ttttgttttt 32100
tttttttttt tttcgagacg gagtttcgct cttgttgccc aggctggagt gcaatggtgt 32160
gatctcggct cacggcaacc tctgcctccc aggttcaagg agtctcctgc ctcagcctcc 32220
caagtagtgg gattataggc atgcaccacc atgcctggct aattttgtat ttttagtaga 32280
gatggggttt ctccatgttg gtcaggctgg tctccaactc ccgacctcag gtgatccgct 32340
cgcctcggcc tcccaaagtg ccgggattac aggtgtgcgc caccgtgccg ggccctactt 32400
ttcatctctg tagatttgcc tgttctgggc attttatata aatggagtca taatgatacg 32460
tggtcctttg tgactggctt ctttcactta gcataagtta cggtccctcc acatggcagc 32520
atgtctcagt acttcgtttc tttttatgac tgaatagttt tccgttgtat gaatctgcta 32580
cattttgttt atccattcgt tgttgatgga cattagggtc gtttccactc gatggctgtt 32640
atgaataatg ctgttgagga catttgtgtg taagtttttg tgtggatgtg tttcaccatc 32700
tccttttaat ccttagcagc tctctgatga gtgggttcgt gtgtgtgtgt gtgtgtgtgt 32760
gtgtgtgtgt gtttgtgtgc atagggtgct tggatattca tggtgaagaa cagttggaaa 32820
gagtcaaggg gcgctgggag ggtgtggcag cagtgccacc ctgcctggca cagaagtgtt 32880
ttggcattgg agctacctgc acagctgtat tggtgaatcc cagcccatgg gatttggcct 32940
tacagggcca cagggcatgt gtgtttggaa gcctgggcct cccctgggac taggccagga 33000
gctggcacag acagcttgct ccttgccaca cgctgaggca actggtgccc cagggcactg 33060
ctgctggcac cttcctgcca ggcatgacct gtggatcacc cgggctcagc ccagtgcccc 33120
agcctgcgtc agcaggggcc acctggaggg ctcctctggg agaggcattc tcgtgtgtcc 33180
cccgcacctc cccgccccgt ggtacccctt gtgagtcacc gtcacactgg gcctcctgcc 33240
gcctacctgg gacatcactc aaccttgtcc taacctctct ccctcccttc ctgcctcatt 33300
tcaggtgaat acatcaagac ctggaggcca cggtacttcc tgctgaagag cgacggctcc 33360
ttcattgggt acaaggagag gcccgaggcc cctgatcaga ctctaccccc cttaaacaac 33420
ttctccgtag caggtgtgtc ttgggatgag tgggtcagtg ttctggtgct cacaggatgg 33480
ctggcacgtc ttaggggctt gtgggacttg gtcattgagc catgggcctg tcctgggcct 33540
gcttgccctt ggatctgttt tcacccttcc cctgctctcc ctccttgtta gctggccagg 33600
cggggctgtc ctgcggggag atgcagagtg ggagggaggg agaagccagg gcatttgccc 33660
acacccagcc ccatgcatcg cctccttgtg gttccagctt ctgtcagcca ggccttggag 33720
tccccaactg gtggcaggtg cctcccatcc tgtgctttgg taacagcctc catcctctgt 33780
ccctcggacg tagaggggtc acagcttccc actcagctgg tcacagggct ggcctcgcgt 33840
cctctgtccc tctgtaatac ccaaagggat gtcttccagc cagaccctgg cagtgaagtt 33900
tcacaagccc caagctcttg actgagcctt ggagaatatg gtcctgtcca catcgctgcc 33960
cctttctgcc gccttccttc cttgctgacc tgatgggtca ccatgtcctg ttgttctgcc 34020
tgctaagaac attacagagg cacccccatc tccactgcca gtgccttagc tcagaccact 34080
atcctctcct gccatgctgt ggaacccagt ccccgtccca cgctgctctg catgaagcct 34140
tttcctgatt gctctccaca tgtgctggtg accctgacac atctgttccc aacctcagtg 34200
tctcactaga actcccagcc tgtcccaggc tgctccttgg acacatctcc ccaagtgtct 34260
tcaaggtcct cataagtgcc acatcccaac ctgaccttca ggcctctccc agctctattc 34320
ctgtctctgt ctcagggaca gcaggccgag aggcctgggc ctggtcctca gtgccctctt 34380
cccatggcct gtctgcaggg ctccactctg gtgtggcccc atcctcccta gctggctccc 34440
cacctccctg gccttccaac ctccagcctc accctctaca tggcagccag agggatcatt 34500
ctcagtctgt ttgtgtctct tccctatcta aagccttcta tggctccctg ctgccctgag 34560
gacaaagtcc agattctttc ccatggcctc caaagccctg cctggctggc cccagcccac 34620
ctctccaggg ctgtctctca cttacccctc ctcacccttg gagcagaatt ggccaccccc 34680
tgaggatgtt gaacctcctc tcacctctga gcgtctgttc tccgtgtacc ctctaagttc 34740
ccttttcctt cagggcttag ttcagagaag ctgcttcctc tgggaagccc cccaaccccc 34800
caggctgggt tggatgctac ctctgagctt ctgcacacct ctaggcttgt ccccatcgcg 34860
gccctgtcta tggagccatc actctctggt gggcttctct ccttccacac acacacacac 34920
tagaccctga gccctgtgag aacaggacca gggctgtctc agtccctaga gtgtccccag 34980
caccatctag catggggcta ggcctgtggg aggtggctcg ggcactttgg gctgcaggct 35040
agcagggcta tcccctcagc cccctgctgt ctgttccctc tgcctgcaga atgccagctg 35100
atgaagaccg agaggccgcg acccaacacc tttgtcatac gctgcctgca gtggaccaca 35160
gtcatcgaga ggaccttcca cgtggattct ccagacgaga ggtcagtctg ggcctctgtg 35220
tggctgccct tgagagggag caagcctggt gtgaggagaa aaggtacagc tggagagatt 35280
ttccctggga ccctacatag gggtttccta tctgcgcttc tggttggggg gtctctccag 35340
ctggggctga gaagagctgg ggttcttagt ctgaagaccc tactctgccc tttgacttgc 35400
gggtgcatcg gaatcacagg cagagctcgt gaaatgtcta gaccgctggg cctcgcctca 35460
agacctgtga ctacctggag atctgcccag ggtcagggag ctacattctt tttttttttt 35520
ctgaaatgga gtttcgctct tattgcccaa gttggaatgc agtggcatga tcttggctca 35580
ctgcaacctc caacctccac ctcctgggtt caagcgattt tcctgcctca gcctcccaag 35640
tagctgggat tacaggcgtg tgccaccatg cccggcttag tttttgtatt tttagtagaa 35700
aaggggcttc tccatattag ccaggctggt ctcaaactcc tgacctcagg tgatccgcct 35760
gcctcggcct cccaaaatgc tgggattaca ggtgcaagcc accacacctg accccctttt 35820
tttttttttt tgagacagag tcttgctctg ttgcccaggc tggagtgtag tggtgccatc 35880
tcagtttact gcaacctccg cctcccgggt tcaagtgatt ctcctgcctc agcctcccaa 35940
gtagctggga ttacaggcac gtgccaccac atctggctaa tttttgtatt tttagtagag 36000
acaggatttc gccatgttgg ccacactggt ctcgaacttt tggccttagg tgatctccct 36060
cggcctccaa agtgctgaga ttacaggtgt gagccaccct gcccggcagg acctacattc 36120
ttaatgagca tctctattga ttttgaggca ggtggtccag agagtcattt taaaaagatc 36180
aatttagtaa tcagaagaga tgataaagac tcatctattt caaaattgaa acagtataag 36240
gaggtgtcta gtgggagctt cccctaccct gccctttcca tccacctccc tgccccccag 36300
ttaatcactg ttcttaggtg ccctcaaaga gcagagggag acctttgtgc ctggctgcct 36360
tttttttttt ttttttaaat acaaaaggta gcattgtaca tgcttctgga cttgcttttt 36420
cccttagtgt accttgggga atttgccttg atatatggag agatgcagct gctttgtttc 36480
atgttttgct tttttttttg gacagttgga catgcgtgtc ccaagtgtgt ttatttagcc 36540
gttctttatt gtgatgactg gggttgtttc cagcctttgg ctcattataa ggaatgctgc 36600
agtgaaatag ccgtgtctgt ctcgtttgat gtgtgcacag gtagacctgt gtgacgagtg 36660
cttagatgca ggattgccga ggcacaggga aaataagttt gtggttttgc gatgtttcta 36720
ttaggcgatg tctgagagtg cccccatggc cttgtgtttt caaacatttg gatttgtacc 36780
agtctgagca gtggaaaaat tcagcacctc ggggtgttta actttccttt ctttctctgt 36840
ggatgagttt gaccctcaag ggccatgtga gttcctattc tgaagtgtct atattgtcta 36900
tttttctgtt gggtagttgg tctttttctt atttatgtat tagctcttta tagattaagg 36960
agctttgccc tttgtaatca gtgggaaatg tttctttttc ccactttgtc cttttgggcc 37020
tcactttgag aaacagtctt ctagcttatc tatggggtaa ggtttcagca gaccctctag 37080
agagccctaa aatcatgccg tccaagaaaa cttccggcca ttgtggaaat gccctttatc 37140
tgcactgtcc agtaggcacc tgtgccaatt gcctgtgccg attgcctgtg ctgactgctt 37200
gtgccgattg agcatttgaa atacagccac caaggaatgg attttttcta gtttatttta 37260
attgatttaa agagccacat atggctagtg gctaccttct tggacagtac agctcaggaa 37320
cccacaatat catgagactt gttactataa tctatactat aattattgtt gcacatcctc 37380
ccaaggtaaa aaatatactt gccccactga ggggaacaaa attaccatct caagccagct 37440
gaggtgctac tcagttgaaa actatggacc aaaacatgaa tggccagtaa aaacagatcg 37500
agaccagtgg gtgtataggt cctgggtgtt gagctgggtt ttgaagactg gataggattt 37560
ggccacggag atagcaagga gaaagttcag aagggacagc atatgcaaag acctggaggt 37620
gaaatagctc atgcattcca gagactacag ggggttctgt gtcaccagag aaccaagggg 37680
ccaggagtgt tggaagaggg gaagtggagg cgctcgaagc tggagagctc agccaaggcc 37740
ttggactcca ggtggagatc cccacagggc ttggcaggca cttagtaaat tgcggtttgt 37800
cccagggtag ttacacgatg caggggaatg ataaatagga gcggctgatg cagcagtacc 37860
tggcacatca ggtactgaca aggtggagct gacaaggtgt tttagtaggc aggagagatg 37920
gtctcgtttc cattttcaca agacaacatg ccctttcctt taccaagatt ctgtaggctg 37980
gagagcccca cctgcctttt cttcttggta cctgctgctg ttgccaaaga gaaaactgct 38040
ggaacgacta agagaccagg tcccagattt ctgaccttaa ctatgggtgg gtggaggggg 38100
tgaaccagaa acccagcaag agggaggccc cctccactct gctcctggct gactgatgct 38160
gtcctcacag ccctggccca cacaggctga tgtcagctgg cctctcttaa gcctggggag 38220
ggaggcaggg gttgcagggc aggtgggtgc cagtcggtga ctgcttgttg gctaggtgct 38280
gcagcgcctc ctcactgggc tcctggttgc ctctccagct ggagagaccc tcctccctgt 38340
cccccacttc actgcagacg tgtttcacat ggagaaaagt tgaaagaata gtataatgaa 38400
tggacatcca cgcgccccac tcctagactc tgcagtcccg cattcaccgt gtctgcttca 38460
tctggttgtg ttttatgctg aacttgaact tgtgttcata cttagtgaca ttcttagtgt 38520
ttcagcaggc atctcctaag aataaggact ttctcctaca gaatcatgat gctgtcacgc 38580
ctgagatgat tataatcttt gtttactagt aacttctcct tatccatgcc gtacttgaat 38640
ttctttagtt accttttgaa ggatatgcaa cctttagaac attgttttaa aaccagtatt 38700
cattcaaggt acatgtctct ttgacttgtt ttatttaatc tagttcagcc ctttgtcttt 38760
ttttttcctc cccaagacat tgatttttta ttaatttatt tatttttttg acaagccagg 38820
ctagttgtct tgtagaatgt cacaccttct gggtgtgtca tattattgcc ttttggtgtt 38880
gtttactttt gttccccatg tttgtatttc ttgtaaacta gaattaggcc aggaacaggg 38940
ttggcaaact atggccctgc cttccatttt tgtaaataaa gttttattgg aacatgacca 39000
tgtccatttg ttcatgaata gtctggctgc ttttggctta ctgtggctgg gttaagtagt 39060
tgtgacaaag actgtcttgc aaagcctaaa aaatttaata attggccctt ttaaaatttt 39120
aattaaaatt ttttaaattt aaaacttttt ttttagagac aagttcttgc tctcttgccc 39180
aggctggagt gcagcggtgc aatcatagct cactgcagtc tcaaactcct gagcttaatc 39240
catccttacg cctcaggatc ctgagtagct gggactaaag gtatgcacca ccatgcctgg 39300
cgaattttta aatttttttg tggagacaga gtcttgctat gttgtccagg ccggtctgga 39360
actcctggtc tcaagcaatc ctccctcctc cacctcccaa agtgctggga ttataggcac 39420
aaaccaccac acccagcttt ctggtccttg atggaaaaag tttgcagacc cctggtcttg 39480
gcaggcaaga atacttaata gtgcatcagg tgagtatgat ctttttgttg ttgttttgat 39540
ggggtctctg ttgcccaggc tgcagtgcag tggcagaatc acgactcact gcagcctcaa 39600
tctcccggat ttaggtgatc ctcccacccc agcctcccta gtagctagaa ctacaggcgc 39660
ctgccaccac accaggctaa tttttgtatt ttttgtagag atggggtttc accatgttgc 39720
ccaggctggt cttgaacccc tgggctcaag tgatctgccc atcttaacct cccagagtgc 39780
taagattaca gccatgagcc actgtgcctg gccatctgtg atctttttga cgtaaatctt 39840
tctttctttt ttttttagac agagtttcac tcttgttgcc caggctggag tacaatggtg 39900
caatcttggt tcactgcaac atcttcctcc tgggttcaag tgattctcac gcctcagcct 39960
cctgagtagc tgggattaca ggcacgcgcc accatgccta gctcattttg tatttttagt 40020
agagatgggg tttctctcat gttggtcagg ctggtctcga actcctgacc tcaggtgatc 40080
tgcccgcctc ggcctcccaa aatgctggga ttacaagcgt gagccaccgt gcctggcctt 40140
gatgtaaatc ttatcatgta ttttctctgc ttagaactct gaatggcttt cactcccact 40200
cagagtaaac tccaaggtcc gtgctgtgtc ctgcagagtc ctgtatgatc cagcgacctc 40260
tccagaagca tttcctacca caagcaccct cacttagcca cgtgtctcct tgctgttcct 40320
taaacatgcc tagcacatct cttgcccgag ggcctcagcg cttgctgtcg cgtttgtcta 40380
aggccttcct ccctgagatg ccatcacagc tctccccgac tccacgaggt ctctgcccca 40440
gtgttgccac cccagtgcgt cctgccctgc ctcccttcgc tgtcttgccc ttccccagct 40500
gtgcttttct tcatagcacc tgtccaccaa gtgggacatt tatatttatg tatgtatctg 40560
gcacacaaat gggtgttcag taaatgtttg ttggataaat aaaaaataat taaattctct 40620
gagctagatc ctgttccgag gacttttcat atattaattt attttctcct cacaaggcag 40680
actatctgtg cacagggagg gccccagatg ccctccagct gtaaatgccc ctctaggtcg 40740
gggaggtgat ggttagggga gagtccccac agtcagctgt cactcctgaa gcggtgagga 40800
cgggcttgtg catgaaggac agccctgcca cctctgcttc gccgagcttc tctctggggt 40860
gccccgcagg atggcccagg gctggggtcc aggccctgga ttcaggccag ctgccgtgtc 40920
tctccctcag tggggctcag ttccctggct gtcatgtggt gtagaggagg aagtaaacat 40980
gaaggcactg gcgcagggcc tgcccatggc agctttggca cacgcagcac tggtaccttt 41040
cttacctctg tctcctctgc caccagcatc tctttcctgg aggatgccgg ggtctcctct 41100
cactgccccc agtccgtagc ccacacagca gctactgact taaaacagaa atttggagcc 41160
tgttcccccc tgactaaaac ccttcagcga cttcctgtgg tgctgaggat aagacccaga 41220
tctctaacat ggtggcacgt agaggccgga gcggtctggg catgctctcc tccctgtcct 41280
catctcctcc actcctccct gtcctcatct cctccactcc tccctgtcct catctcctcc 41340
actcctccct gtcctcatct cctgcactcc tctctctcct catctcctcc actcctccct 41400
gtcctcatct cctccactcc tccctgtcct catctcctgc actcctctct ctcctcatct 41460
cctccactcc tccctgtcct catctcctcc actcctccct gtcctcatct cctgcactcc 41520
tctctgtcct catctcctcc actcctccct gtcctcatct cctccactcc tccctgtcct 41580
catctcctcc actcctccct gtcctcatct cctgcactcc tctctgtcct catctcctcc 41640
actcctctct gttggctcca gccattctgg cacctgtgtg cctttcacag acaccccagc 41700
ttgctcctgc cctggggtct ttgccatgca gttccctctg cctgggttcc tttccctccc 41760
aatcccctgc ctccttccct ccatttcatt tatttcatag ctgtgtgcca agggcctgtt 41820
ctaggcactg gggatggcca ttgttcaggt cctggtttaa acgtcatctc ctcaggcctc 41880
ccctgactgc cctctgagaa ggagtctccc tgtttggccc ccgccttgga gcttctacac 41940
acttgtcctc cccttgaggt caggagccat gatgggcttg tcccctgctg catccacagt 42000
gccctgaaca agcctggtgc acagaaatgc tccacatttg caggccggct gggtgaactc 42060
tcatgacagc cttctgagac ctcaatgtgc tgggcaccgc tctcagcact ttatgtctag 42120
tgtctcattt caccctgata ggaccctcta gtgcctcacc caccgaggca caggaagggc 42180
atacaacctg cccagtgttg cctgcaggaa ggggcagagc tgggatccac gtccaggcca 42240
tcccccagag cctgtcctct cacccactgt gaggtcccca gctggtacgg aaggcaggca 42300
gcgcattggg tggcaatgac cccacagctc ctggcccaga gcctgtgctt gccccgtact 42360
gtgcccttcc cagtgttggt atggcgaacg tggctccccc atgtccctcc cctggccctg 42420
agcccaaatg aggatgagaa ggttccagaa aataccgatg ggggaagtgc tcttggaggt 42480
agaagtgcct gggcacttct tgtgtccctg gcctctgtcg gtgggcagat gagcctctct 42540
gtgcttcggt cttgtcattt tagcatgaag tgaatggcag tacctactac acagggttgc 42600
tgggagggcg acaggagtcc tccaccataa cgcacagtgg taccagcctc tgcaagtgga 42660
aggtgttctt gggactgctg ttgagtggca ggggtggggg cccctctctg aaaagcgggt 42720
gcagatcatg gcttacgagg agagttcttc ctttgctttt cccgtgggct ccctggctgg 42780
gtgtcccatg agccttccct agagagggtc cctgctttac cctcctgagt ctcgtgtagc 42840
tttcagcgct tcactgaggc tcagggacag gcgggtggtg ctaaggagga gtaggctgtg 42900
cacaggtgag tgccagctct gccacatccc tgctgtgtga ccttcacagg tgactccacc 42960
tccatgtgcc tcagtcccca cagcagaaat gctggctctt gagaattgca gtgctcttga 43020
gaatcaagcg aggtggtgtc tggagctagc cactcagtgc tgttattttt acagtcgtgg 43080
tttacccagg ggctctcctc tgggggctag aagatacttg aggcccagct tcatggggag 43140
ctcccctttg ccccagacgc catgttgcaa acccttgaga aggatcctgg acagaggccc 43200
ttgcttttca tctggaattc tgagtgctgc aaccttgcaa ctttggtcca gttagaattg 43260
gatcggaagc tagtcaggca gcaggcgagc cccagttact cccagataac ctcctgcatt 43320
gctgtggttt ctggagcttt ctgtagggtg ggcagtggga gccagggtag gtggggtagg 43380
cccgcccctg cgagtgtctt cggcaccctc ccttccaccc cgccctgcgc gcggtgctct 43440
gcgccgacag cccgccaacc tcttagcccc aggcccaggc cctggtggag gggagagctg 43500
ggagggctga gctggtccag gtggcagagc cactcttgga gccccagctg gggtgggtcc 43560
agggcctgtg ctcctgattc ccatctggag tagcctccca gagctgcttc tgggctggtg 43620
gtgtggcagt gccatccttc atgtatttgg gttctctcca cagagggacc atctgtgttc 43680
tctccacccc tgtctttgaa aacaaagatg ataccacgct gtacatctta gtctgcaatc 43740
tgccatcttc acgtgacagt ctctcaagat ctttatatat gagagacata ttttcctttt 43800
taatatcttc actgtatctc ttaggagatc tgtgattttt tttttcccaa tccgccatca 43860
tttactcaga gtcagcatta aaaaaattta aaatttgtga gaggacaact atgtctgata 43920
aagcatgtca tggaaggctg ggcacagcag ctcacacctg taatcccagc acttggggag 43980
accgaggcag gcagatcatg aggtcaagag atcgagacca tcctggccaa catggtgaaa 44040
ccctgtctct actaaaaata caaaaattat ggtggcgggt gcctgtagtt ccagctactc 44100
tggaggctga ggcaggagaa tcgcttaaac ctgggagcca ctgcactcca gcctggcagc 44160
aaagcgagac tctgtctcca aaaacaaaaa gaaacaaaaa agaaaaaagc ctgtcatgga 44220
atgggctcct gccctgtccc cggcccctgc tttttttttt tttttttttt gaaaaacagg 44280
aatattagtg tagggtttgg gaattaggct gtaatttgtt cctaaggggg catgggttaa 44340
agcaagttga gaaatactgg cttgagatgt tgggccaggg agtgcagaag ccaacaccgc 44400
tctgcccggg tgtgcaccag ggctcagtgc gtgctctgcc cgggtctgca ctgggccctg 44460
ctgcgccctg gccctggggc cacttggact ttggctgcct cactctttca ttacccaagt 44520
atctactgag tatccaccat gagttctggg ggcagaactg tgttcaaagc aggtggaaat 44580
ctctgcctcc gtggggtgga catagatggg ttatggggac tccagtctct gagtgggtgg 44640
ggagggcagc gtgccttttg taattccagc taccaagcct ggagcaactg ctgtttttct 44700
ggaatctgtt ttttcaatct gtgccccagt tcctccttca taatgggtgg gagtagggat 44760
agttgatgat agcaagtgct tcccatttgt tattagaggc tgttcctttc cttcgactcc 44820
cagttcccct cccttggagg caggcagggc tccaggatca tgacttctct tctggagatg 44880
tttgtgccta tgtgagcatg tgtctgcaga agttcattat tttctaactt aggagcacag 44940
aactgtatac tgttcttcac cttccttaat tttgaaattt tttataaagg cgtggtcttc 45000
ttatgttgtc taggctggtc tggaattcct gggctcaagc agtcctccag cctctgcctc 45060
ctaaattgca gggattacat gagtgagcta ccttgcccat ccctgcacct tcctttttct 45120
cttaagaagt ctcagatcat cccaagtcag catacagacc tgcctcaatc tttcccccag 45180
ctgcagaatg tctcattgca cagatgcctc acaggcattc tacctcacga cagcctgtgt 45240
attaaacact gctgtgatat ttcatcaaat cgaaggcgct gtcattgggg aggcaccctg 45300
tttcatatag tgccaagaaa aaggcgtgcc cagttaaatc aagacagacc ccaactgtga 45360
gattaatctg cattccagca gtgtcaaaat gtggaagagg gtgcgttgtg ggatggatgg 45420
aaatagaagt agtttcgcgt ggtacaccag gaaacgagac tggggaggaa tacagcccag 45480
cagggtgtcc cggcttggat tttgaagccc agtcccagcc acacttgttc cctgcctgac 45540
cttgggtagg ggccccagtg tctcaggaac acaggagcag tgacacttgc cctggggcgg 45600
gggccatcct ggaagatgct gtgaagggct ggctgcactc cctgtggctt atttaaatca 45660
ctgggatttg cgtgattaca ctctctgaat tttctcattc ttagtgaaca ttttattttt 45720
cttgttggtc atatgagtat tttctagata caagcaaaat acacgggggg ttcaaaatgc 45780
gttgggttga aacacctaat tgcagtgtgg tcaaaaatgg gggatgtgga caatttggtg 45840
taattcagcc taatatattt ttcattttgg tctctggtca ttttcactta ttagacagaa 45900
cagtttgtaa gtatccaaag aaaattattt tgtttttttt ttagctgatt gcagtggtat 45960
gatcatggct cactgcagcc tccacctcct gggctcaagc agttctccca ccttagcccc 46020
ctgagtagct gagaccacag gcatgtgccc ccacacctgg ctaatttttt atctttggtc 46080
tctacaaagt gggtatccat gttgcctagg ctggtctcaa acttccggat gcaagccatc 46140
gtcccgtctc agtctcccaa agtgccagga ttgcaggtgt gagccaccga gcccagctca 46200
aagacagttc tttctcagca agttctaaac catgagtgac agaactagtt tattgttctt 46260
tattttatta ttattattat tattattatt attattatta ttttattatt attttgggat 46320
ggagtctcgc actgttgtcc aggctggagt gcagtggcgc gatctcggct cactgcaacc 46380
tccgcctccc gggttcaaat gatcctcttg cctcagcctc ccgagtagct gggattacag 46440
gcgcccgtca ccacgcccgg ctaatttttt gtatttttag tagagactgg gttttactat 46500
gttggccagg ctggtctcga actcctgacc tcaagtgatc ctccaccttg gcctcccaaa 46560
gtgctgggat tacaggcgtg agccatcgca cctggcctgt ttttattttt tatttttgtt 46620
ttttaaaaac tttttaagag atgggtcttg ctttgttacc taggctggtc ttgaacgctt 46680
cggctcaagc acttggtcca ccttggcctc ccaaaatgct gggattacag gtgtgagcca 46740
cagtgcttag cctctagtta actgttctta aaccaggctc ccttctgctg ggacctactt 46800
cttgtccacc agcttctctc ctctacatcc ctgggctgcc aggacctctg tccctgccat 46860
gcagactccc tgctcccagt ggactgtccc ctccagggag tcctgcgggc cagctcttgc 46920
cttgcagtgt cttcagctcc tttggctaat gaatgctgct tcttactctt ggtttaactt 46980
tacaaaacat tggtaactta taaacttgag cttgtcattt gttccgaaga attcacagga 47040
gcactctctc tccctcattc aaggctcagg gtggtggctc attttcaagg ggctgtgaaa 47100
agagagggtc actccttttt gatcatttcc ctgctgcctg gcttcaaatg gccctcaggc 47160
caggtcactt tagggaaatt ggtgatcgct cttggtattc cacttttttt ttttttttga 47220
gacggagtct cgcactgtca ccaggctgga gtgcagtggt gcgatctctg ctcactgcac 47280
cctccgcctc ccgggttcaa gcaattctcc tgcctcagcc tcctgagtag ctgggattag 47340
gcgaatgcca cccctgacta atttttgtat ttttagtaga gacggggttt caccatgttg 47400
gccaggctgg tctcgaactc ctgaccttgt gatccatccg cctcagcctc ccaaagtgct 47460
gggattatag gcatgagcca ctgcgcctgg cgtggaattt cactcaggtc ccttcagctc 47520
tctctggttc tgacagatct tgcccaaatt cccatggtta tgtggtcatt tgcttgcctg 47580
ttgctggggg tggctgggag gtggcactca gctgttcgac tctgaggccc aggactcctg 47640
gctgctggga ctcacgtgtg tccctgcaca gggaggagtg gatgcgggcc atccagatgg 47700
tcgccaacag cctcaagcag cgggccccag gcgaggaccc catggactac aagtgtggct 47760
cccccagtga ctcctccacg actgaggaga tggaagtggc ggtcagcaag gcacgggcta 47820
aagtggtaag tgctgggagc aggggtgggg ctgccagcct gcggtgcccc cacccccagt 47880
gctggcctgc tctccttggt ttccataaca cagttcaggg ggctcagctg agagacaagg 47940
ctgccctgca gggtggggtg atttcaggtg gcaggtgccc tagggtgtgc tccatgcccg 48000
taggggaggg agcaaccttg ggtggaccca ctgcaggttc gtcctgggag ttggtgaaga 48060
cctggctacc cccacgtcag agcccagccc tcccaaggcc ctgtgcctgc agagcctggt 48120
ctgaaggccg cttcagaaca cacagttgct gcccagagcc tcccttcctg ctccagccta 48180
agccgtttgg caacagtgtc ttttggtttt cctctttctt ttgttaaaat ttcctcccac 48240
gggccatgag ccaggcgctg actgccccca ctctccctgt ccctggcaga ccatgaatga 48300
cttcgactat ctcaaactcc ttggcaaggg aacctttggc aaagtcatcc tggtgcggga 48360
gaaggccact ggccgctact acgccatgaa gatcctgcgg aaggaagtca tcattgccaa 48420
ggtgcgtgcc ccgggaattg cgctcgcgag cctctgtggg ggctgcggtc tggagcctga 48480
ccctgaggcc tggacgctta cccgcgcttt ctgctgctgt gggcttattt cccccacaaa 48540
ttccccctag tcagaaaagg gggagcctga ggcccagaga ggagcagcag gccttgctgc 48600
tgagtcccca cctccaccct atgttagggg ctgggggtgc ctgtggagag agagagcctc 48660
ggggccccac ccagcaggta ctgtcaaggg aggctggggc ctgttgggga ggacgtcgct 48720
gttggggagt cccgggcttt gctcagggta tcccaggtgg aggccgggcc aggagtggaa 48780
ttctactttt tcccttattt gaattttttg tagtggaaga ttccaaagac attcaaaaat 48840
ttaaaaagaa aataaatatt acggaccccc atgtagccat tgtccagttt aaccagttat 48900
cagcgtttag ccagccttgt ttccttagct ctgcctgtcc ctcttgttct ggaatacttt 48960
aaggcctgtc ctagacaaca cgtcacttca ctcatccata cttgaacatg tgtcctgaca 49020
gatgaagact gtaaagaata taatcatgtg gtgctgccat cagagccaac caaattagct 49080
gttcattcct gatgtgacga ttgggcctaa ggcagccttc ctcagcctca gcactgttaa 49140
cgttttggga cagatgattc tgcgctgtcg gggcagccct gtgcattcta gggtttcagc 49200
agcacccctg gcttctaccc actgaagcca atactagctc cccaagttgt gacaatcaaa 49260
aatgactttt gggttgggcg ccacagctca cgcctgtaat tccagcactt tagaaggctg 49320
aggtgggagg atcgcttgag cccaggagtt cgagaccagc ctgggcaaca aagcaagacc 49380
ctgtctctgt aaaaataaaa ataaattagc tgggcatagt ggcgtgcacc tgtagtccca 49440
gctgctcagg aggctgaagt gggaggatca gtggagcctc agaggttgag gctgtagtga 49500
cccatgttca caccactgca ctccagcctg ggcgacagag ccagaccccc agctaaaaaa 49560
aaaaagggaa aaaaaaaaaa aagacttcag acattctcag gtgtcccctg gggataaact 49620
tgccccagag agagcctgtg ttcacgttgc tgcaggtggc tccagatttt tggaaccact 49680
cctggtggtt ctgctgtaca gtcaggtacc aaattagaac ctgaattaga gtcacccaaa 49740
gggcttgtga gacagtgctg ggcccacccc gagtttctga ctcagtgggc ctgggggtag 49800
gtcccaggaa tttgcattgc tgccagttcc caggcggtgc tgaggtgctg tgtggggacc 49860
acaccaagaa gcactgtttt tccttctttg ggcaagaatg ctttctaggt gggacttccc 49920
acagcctgtg gtggcacctc ggggctctcg tgatgtctgt ttgtctccct tgcagggacg 49980
tcacaggtgt cttgtcccta gcagcctggt ccttacattg tgacattcct gctgactttt 50040
cacctgtggc tttgagagcc actgatgatc ctcgtctggg tctgctattt gctgagggtt 50100
tgcaggcttt cacttttcac tcctgtgatt ttctgcattt atggctggga atggaattgc 50160
atttcacaag gccttgctcc ccttcgtcgg ggcggagtgg gcaggtgtgg tgttgcccac 50220
cagcccctca cccgcagtct gtctgcagga tgaagtcgct cacacagtca ccgagagccg 50280
ggtcctccag aacaccaggc acccgttcct cactgtgagt tgccctcccc ttcccagaca 50340
gtgtgaggcc agcctttgga cagagctcag agagagagcc ctaatcttct ggtacaaagc 50400
acagtcttgg ggtaggccag gcgggcaggg caaggtgttg ctgcgccctg ccaagtcatc 50460
cgaaccaaga catgtggtgg gggtgagcag gctcggggag tgggagggtg acagcttctt 50520
catagatggt ggcttcatgt aagcatttga actaactgaa gatatcacat tatttgctgg 50580
ctgctgtctc tatgagttag gagcacttag cccagctggt tgaagtggaa acattatttt 50640
ttttgttttt gttttcagat atgctcatag aagcagatgt gttagcattg tgttgtctgt 50700
cagcctggac tgagtagatg cctgtttggg ctgcagtctc catcaaggcc agtggccacc 50760
agttaaatgg actagattga ggatggctta tgtatcattt ctttatctca gttgctgtcc 50820
aggtatccta ttaagccaca gtactttttc aaataaaatc ttatgaggta cctcagtgca 50880
gaaaacagaa tagttgagtt gtcatgagct gaaggacccc ctggtgggag tctctgagga 50940
actctctgta gatctcctta gtgcagtgga gaactactgt ttgttgactg acagcctgtc 51000
catcctgtca ttgaagttgg ctcccaagcc tttgccactc ccagccacag cagacatcac 51060
ttgtgtgtgt aagttgaaca cattttactg taaaaacaag agccatggtt gctcagaaca 51120
gctctagttc tcccttggct gtgcctgatg gaggcagagg acaagatggt tcagcatgta 51180
accctttcct accgcagagc catgccttca cttaatgccc caaaaggtgc agccggtatg 51240
tgaaccccat atggctgact cctgggggcc ccagccaggg cagggtgtgt gtgtgcagaa 51300
taagcagggc cagggccctg ccctggcatg gctcagcaga gccctcctcc ctcccacctc 51360
ccaccctgct gccttcatcc cccaggcgct gaagtatgcc ttccagaccc acgaccgcct 51420
gtgctttgtg atggagtatg ccaacggggg tgaggtgagc cgcggctgcc ttgactttgc 51480
cctctggggc ctccttcttt agggtggggc gggatggaga ggagctgtgg gtgagatgga 51540
agggtggagg gaaatttcag tgtcatctag tgcccctctc ccttgaggca ggcggcttcg 51600
tctccatttt gggggggcag tcactgaggc tcagagaggt taagtggctt gcccaagttt 51660
acacagctag tgagtgggtg ggtcaggtcc aaaccagtcc agagaggtgt ggagagggct 51720
gtggggcgat agcactggga aggatggtct taaaggcccc agagaaagcc cccaagggtt 51780
aaaacctagc agccctccgt tcccgtgtcc tctcgaagtg aattcccgca gccgctcagc 51840
ttccccttac agagtcgcct cacttttgtc acccactcct tgcctcgcgc cttctctgtg 51900
cagtggttgg cacacctgct ttgggatgcg tggtttgctc atctgtctga tctgggcttg 51960
cccatggcct attgttactt ggtcatgacg tgtgcttctt tttgcctcca tgccatcctc 52020
cctcctgtct cggatgtctc tcccataccc tctcatgggt gcctcctggc agaccctcgc 52080
ccttcccccc agctctgtgt cacttatgag cttctgcgct ctgccttgat tggtccctct 52140
agctgtcact tgctggttca tgatacaggt gtcaccacat cactgcgctg gggcaggggg 52200
ctgggaaggt gagggcaggt gggtgggctg gggcctgacc tcctctcccc accccttcct 52260
cctgcagctg ttcttccacc tgtcccggga gcgtgtcttc acagaggagc gggcccggtt 52320
ttatggtgca gagattgtct cggctcttga gtacttgcac tcgcgggacg tggtataccg 52380
cgacatcaag gttagtggca gggtgtgcgc caggctgacc tgtggcatgc acaccacatg 52440
ggactcacac tggggaagtt gggctgagct tctgccctca ttcgccaggc tccccaccaa 52500
ggtccagggt ggtggctgcc ctcattcgcc aggctcccca ccaaggtcca gggtggtggc 52560
tgccctcatt caccaggctc cccaccaagg tccagggtgg tggctctgtg gcaagttgcc 52620
ccaagtaggg accttcccaa gcctcccatg agcgctccta ggccactagc ggagtgtcaa 52680
ctgccacaat acctacttta tttgtattta tttatttatt tatttttgag gagtcttact 52740
ctgttgagtg cagtggtgtg atctcggctc gctgcaacct ctgcctcccg ggttcaagcg 52800
attgtcctgc ctcagcctcc cgaataggtg ggattacagg tgcccgccac catgcccagc 52860
taatttttgt atttttagta gagacggggt ttcatcatat tggccaggct ggtctcaaac 52920
tcctgacctt gtgatccacc cacctcagcc tcccaaagtg cttggattac aggcatgagc 52980
ccccgcgccc ggccaatttt agaagatagt ttggcagtgt ccaccaaagc tgagcaccag 53040
tcatctgccc tagctgtgtg cacaggagaa gtggggacac acactcacct tagaaagtgt 53100
ccccctcact cagcagcagg acttactcta gccccaactg gaacaaccca agtatccact 53160
gtgagaggaa cagtcagatc cactgtggag tgttctcaca gtgggacgcc acacagcagt 53220
taggaatgag ctacagctac acacgacagt gtggacgcgt ctcataggct aatgtcgagg 53280
gaaagccgca cagaggaggt gagtccacag ttcacaggtg tgtctgtgtg cagtggtaca 53340
gatgggaagt agaggttaat tcttgtgggg gatggtcagt aaccgggagg ggcacacagg 53400
gccttccagg gggagatgcc acctcagcct cgcaagtagc tgggactata ggtgtgtgcc 53460
accatgcctg gctaattttt tttttcatat taagaaatat ggagatgggg tctcgctgtg 53520
ttgcccaggc tggtctcaaa ctcatgggtt caagcaatcc tgccacctaa gtcccccaaa 53580
ttgctgggat tacaggtgtg agccactttg cctggctgca tatttcataa ttaaaggaca 53640
gaaagtctag aaaaaaagaa tagaagaaag ctagtgcccc cacgttcgaa ataagaacca 53700
cagttcacaa tggggacggt gggtggacag ggcctggctc tcggctctcc ctgcccagct 53760
gttcccaggt accatggggg tgggccagag ggtgaggagg gttggatctg gcctctctct 53820
gagcctcaga gggtgaggct gtgtgtgctg ggcccagcct ggcatgggag ggttgatgtc 53880
caggagcccc gggcatcttt ccctggaagg aaaggctggg gtggcaggaa gccttgggag 53940
catgcacctg agatccgttg acttttccaa cagctggaaa acctcatgct ggacaaagat 54000
ggccacatca agatcactga ctttggcctc tgcaaagagg gcatcagtga cggggccacc 54060
atgaaaacct tctgtgggac cccggagtac ctggcgcctg aggtgtctgg ggttggtggg 54120
ggtaggaacg tgtgaggcca agggtagggg gatcccccag acctgtgtgt ttccagccca 54180
gatgccctga gggcaggact gtgatgccag cctcagggcc acgggcccag ccctcatttc 54240
tcctccatcc tcaggtgctg gaggacaatg actatggccg ggccgtggac tggtgggggc 54300
tgggtgtggt catgtacgag atgatgtgcg gccgcctgcc cttctacaac caggaccacg 54360
agcgcctctt cgagctcatc ctcatggaag agatccgctt cccgcgcacg ctcagccccg 54420
aggccaagtc cctgcttgct gggctgctta agaaggaccc caagcagagg tgagggctgg 54480
cgtcggcccc acccagccca gcgccagctg ctgccactgt ccctgcggcc tggagggggc 54540
agcgtccaca agggtgctcg cttgtagggt cgcagtgtgt cgtccccaca cagcccctga 54600
aaacgtccac agtggcactt agggagtgct tcccccaggg caggcccatc cttgacactg 54660
ccttatttta tggggacact gaggaacagg gcatcccctg ggcctggctg gggccaccaa 54720
accatatgtg gcagagccag gataggaacg gagcctgccc tactaactcc ctttctggac 54780
tcagggtaag gccaggcagt gaggacacgt gggtccgggt tgctgactcc ctggctctga 54840
ccctgggcac gtgagctccc tccctgagcc tcggtttcct cctctgtgaa gtggtttgtg 54900
gtcaagacag aatcattaag ggccatacag ggcctgcctg ctccgaaagc ccgtctgccc 54960
gaacccagct gctccgggag gcaggtgctg acggccgtct ctgcacaggc ttggtggggg 55020
gcccagcgat gccaaggagg tcatggagca caggttcttc ctcagcatca actggcagga 55080
cgtggtccag aagaaggtga gccccactgc ttgccccagc aggaccctca gggacctggc 55140
ccactcgtgg tgaccttggt tgaggcctcc tggcctcagg gtccctgagc ctgagctcct 55200
ctcctccgta gctcctgcca cccttcaaac ctcaggtcac gtccgaggtc gacacaaggt 55260
acttcgatga tgaatttacc gcccagtcca tcacaatcac accccctgac cgctgtgagt 55320
gcctggggcc cccgcgctgg tgtgcctgcc ccaggggtgg agggatggga tctgctctta 55380
actcacttct caaggagggc cctcgaaggc ccccgcttca tgtctgggag atttccccaa 55440
gtctgctctc aggccctttt gctgttggtc ctctttggac ctggtgaggc caccaggagc 55500
cattgactgc agcacgttct ggagctcagt cggggggctc agggcaggag gcagcccggt 55560
ccctgagcct ggctgggttc actgctttac agctgtttgg gttcttactc tgaactcagc 55620
ccagggctgg gctatgctgg ggacacagca ctgattgagc cagccctggg ccctgccctg 55680
gaaagctccc agcccaggta gggtgggcgg cctggagtgg tcagggctag ggcgtgggag 55740
gccagggact ggggaatccc agaggaaata tccgacctgg cctgcagtta gggagggctt 55800
tctagaggag gaagcaaacg tgtcagctgg ccggaggaat gacgtgtggg atgccagcaa 55860
tgggagaagc atggcatagc taaggaccgg cagcagccag ggagatggtg gtgagaagag 55920
agggcatggg gctggagtgc aagggtctgg gggccactgg gaggggtggg gactgcttgc 55980
atggcgggag ccagccatgg aagggtttca tacagagagg gacagggtta aagcaggcct 56040
ttagaaagcc cccctggctg cccgtggaga atggatggga gggtgcgaga ggcaggccag 56100
gacagggctc tgggctggac tctggcatgg tggtgtgtgg ggcagagaga aggtgggagg 56160
ctcagaaggc cctgccagct gtggggcgca tgggcaaggg cacaggaaac tcccagagga 56220
ggccgcccgg ggctcaggtt tggggagtgg gtccgtggct gagggcctcc attgcggagg 56280
gatgggcctt tcctgtcctg tcctgtgggc agcccccgcc agctggggcc gtttccccag 56340
ggagtctggg caggtgtccc aggccctctc ctgactggtc ctccccatcc acctctgccg 56400
cccacagatg acagcctggg cttactggag ctggaccagc ggacccactt cccccagttc 56460
tcctactcgg ccagcatccg cgagtgagca gtctgcccac gcagaggacg cacgctcgct 56520
gccatcaccg ctgggtggtt ttttccccct aactttttac ttagcctttt tggtttgtgt 56580
ccccaccccc acctcctcac cccctttcca gttcttcttc aggcccctcc cagacgcacc 56640
ccagcggccc ctgcagcccc tgcctccagc ctccagcctc acctttgtgc ccagactcgc 56700
atttggaaga ctccacctcc cgcccaggcc tgggctgttg ggcggttgga gattcaggtt 56760
ttaatccaca caagccccag tgaggggtga agcatggcgc ctggggcctg cctgagtttc 56820
tggcctgggt gtcgtgctgg tgtctgcctc cgcgctgctg catctggacg aaggctgcct 56880
tctggtggga cgcgacaccc ggcagacagt ggtgctgcct tccaggcccc gtggcctagg 56940
ctcggagtgg ccaggcacgg ggcggtccaa tcccccaccc gctgtccccc tatgggggca 57000
gaaaagcaat aatgtccagg ggcaggcagg ggcccttggg agctgcaggg ctgggggtta 57060
gggctgctcc ctggtgaatg gagtcagatc ctaggatctg taccatgggg aaccaggagt 57120
ggccgggctg ggtgccgcct cctggtccgg cctcctcccc accaaactgt cctcacccta 57180
tggatgaggc aggaggaaca tttggggcca aacctgcctg cctcccagcc ccgtgcctta 57240
ctagggcttc cttccagctg gccttacctc ccgctggacc ctgggcctgg cctggcccca 57300
ctgggggcta tgggctgggc tcaccctctc ctctgcgggg gtggagggcc accagccttg 57360
gctgttacaa tcttacaccg gacagtattg ggccccatgg acttggtcag ggaggggtgg 57420
gggtgggcat ctctggtacc tattggggtg gggggcctct gaaaagggag gctcctaggc 57480
ccccctcacc cctccctctc cccagggccc cacgttctgc agccttaagg ttgaacatga 57540
gtgcacgtcc atgtcagtgc tgtgggactc ctgtgcgtgc ctcggactgc gtgtgtcggc 57600
gggacgcagg cacacgtggg tgtgtgtgca tgtgtgtttg tgtgagggca gcgtgtcctc 57660
cagtgtgcat ggtgtgtggg cttgggcccc atccctggcc cgagcatttc atcctgtggg 57720
ggaggggtgc tgacctagtg ggaggagccc cactgtgatc catgagctgc cctgcccacg 57780
cctcccctcc ctgtagcaac acctctgggt gtttggagtt tagcttttgt gggtttgctc 57840
tccctatccc atctcctgta ctacacagtt catggcaggg tggggagggg tggggttggt 57900
tcgggtgggt gagggtcttt ttcctctgtg tgcgatgttg ttatctgaca gttctccgtc 57960
cctactggcc tttctcctcg tcttcatatt tgtacggtac aagcaataaa gacactcatt 58020
tcagaccagg gcccagcctg cactcacgcc agcccaacca ctctgggctt tgccttggtg 58080
atggagtcag acccctgggc cccagctcct cctgtactag ccgttccctt cagcaaggag 58140
ggcactgagc tcagggtgag ggcagctggg gtgtgtgcag gagctcaggc tggagagggt 58200
gggtggagct ggtgctgtgg ggctgagggg tatgggaagg ctccccgcat gtgggggtgg 58260
ggtggacaga gaccactcca ggccctcagt gctgcttagg ctaagagagg tggggtggag 58320
ggacagggct ggaagatctg ggtagcccag aatgaggagg gtgcctgtgc tgtcactgaa 58380
tgagagggag tggttcattc cacccggctg ccgagcctca gaggggggca ttcctatcct 58440
gccccacctc cctgtttatg ctgccacctg gaagccttga ggcccccaaa ttccagtaca 58500
gacccagtgg tgtgttcatg gtggcgtggt tgctgtcacc tgggagctcc tgagcgtttg 58560
gttagaaccc tgttcagctt ggggtcagcc ctcccctagt cactgccctt tagcctggat 58620
gtgtctgggc ccctgcactt cccgtgcttg agtcacgtgg ctgcatggcc gggcgctggc 58680
cggatggaac acctccccca gcaagggacc agggaccaga gccctggcct gccctgctga 58740
gccctgctgt gcagagggcc tggcacagat gaatttgaga ttttgccgca aggtgttagc 58800
acttcacacc cattgagtct ttgagatttt aagtgaatgt aagcagaaaa agtcagatcc 58860
aatttacaga aatcagagtt agctacagct aggactcgtt tggttggggt tttttagttt 58920
gtctttctaa agtcatgtgg accttaattt aattacaaaa gtctaccctg gtggtcataa 58980
aataggcagg cctatgaaga aaggcctttt actcttccat ctcgtcccag ccccgagttg 59040
acccacgttg ctgctcctca caccatggtg atgcaggtct cgtagtgtgg gcacaggcct 59100
ggctacctca tctttttagt gcctctctcc tcttccacag gatggggtcc cacagctgca 59160
gcagctggcc ccgtagttga gcatgtgtgg ttatcctgta gagcttttcc caagaagggt 59220
gtttgaactt agagtcttaa taaaatctta ccaaataaat tttgagtaga ataatcgtct 59280
tttgcaatgt acattttaaa aatttcacac attctttttt gtatataaag aacagtgact 59340
gggcacagtg gctcatgcct gtaatcccag caatttggga ggccgaggcg ggcgggtctc 59400
ttgaggccag gggttcgaga ccagcctggg catcataggg agaccttcat ctctacaaaa 59460
aatacaaaaa ttagctgggc atggtggtgc atgcctgcaa tcccagctaa cttggaaggc 59520
tgaggtgagg tgggaagatc acttgagccc aggagtttga ggctgcagtg agctatgatt 59580
gcggcactgc actgcagcct gggacaatga gactgtgtct ctaaaaataa aaaaaaaaaa 59640
aacatgatac atgctattaa aaaagacagc aaagcaggag tataagaaag gaaattcacc 59700
cgaggtcgca gggccttgag tactcatttt ggtgctgatt acctctctgc aaatggacac 59760
ggcatcataa attggtagtt tcctgctctt tttgtgtaat cttttccagt taatgtgaag 59820
cctctggggg ctgccctcgt gcactgatgg ttgtgtggag tcgggggcgg cagtgcgatt 59880
cccttttagc tgctgcatgg ggggaactca ggctttccag ctgcttcctg gggttccatg 59940
gggtagaccc ctcaaccgct tcagctgccc cgttaacagg aattgacttg gtttcgtttg 60000
gtgctaccag cagtcctgta ataaactagc tatccatctg tactgtgctg gtgcttttgt 60060
ttgtctacat cccaggattt taatgtccag tacctttcca aaaaagtgta gccattcaga 60120
tactttaaat tttgaaataa ttgcagactt gcagaaaact ttcaaaaata gtgctgtact 60180
aagattattc caggcctggg gcaggaaatg tacaagatga gcctggggca tcttgcagtg 60240
cctgaaagca cgcactgata tgcttaagtc acagggacac aggagccaac agaaagcttc 60300
cagtggccaa agctgaaaag aatttgaaca acaaaataaa tagcataata ttgggttttc 60360
acctaaaatg tgaaataagt ctattgctaa gtggcaaaat ggggagaata tgcaaatcta 60420
cacaaaatca taagtaattt ctgtagacag ccttcaagga gggctatgga acccccactt 60480
cttaggcgtg ggctgcagtg actcctccaa agagtgcagt gtggagaggg ggaaaagtaa 60540
cttttcagtg aaggtccctg gcaaacacta catcatccag ccaatcgagg caaacactgc 60600
tgatgaatca ccttcacagt gtccctttaa tgtgatagaa tggcactttc cctctgatcc 60660
tcctcttgca gacacacacc acctcactga gaggaagcag acatcagaca gatctcagtt 60720
gagggatttg tctgccaagg tggttaatca gaaaattctg agaaagtgac acatccaaga 60780
tcaaccaaaa gagtcatggt gactaaatgt aatgtttcct gaaatagaaa aagaacgtag 60840
ggaaaaagga aggcttgaat aaagcatgga cttaatagat gaatattggt ctaacggatt 60900
gtgacaaatg gggcacacta atatgagatg ttcattgggg aaattgggtg tggggtaggt 60960
gggaactgtc aatctattca aaaaagttat gtagaagaat tacaaaatat acccttcgcc 61020
aggttcgtca tagcatttta cttaaaacgg acaaaaatgg gatcagaatg ttaaattcac 61080
ccctccacct cccgctccac attgtatacc tgtcctaaag aacattctgc tacataactg 61140
ctctccagtt accaaggtca ggaagctaac attgaaactg ctcttctgta cagattttat 61200
agtgttcgct aatggtcacg cttaatgtcc ttgtatgtta aaaattccta gctaatgacc 61260
aggctcacat gttgcattca gttggcaggt gtgaaactca cagggcagtt attttgcagt 61320
tattttccct caaccagggt tggttgcctc actttttttt tttctctttt ttttaagacg 61380
gagtctcact ctatcgccca ggctggagtg ccatggtgcg atattggctc tctgcaacct 61440
ctgcctccag ggttcaagtg attctcctgt ctcagcctca ccagtagctg agattacagg 61500
cacccaccac cacacccagc taatttttgt atttttagta gagacagggt ttcactatgt 61560
tggccaggct ggtctcgaac ttacctcaag tgatctgcct gcctcacctt cccaaagtgc 61620
tgggattaca ggcgtgagcc actgcgcctg gcctaaaaga tatatatata tatatatatt 61680
tttttttaaa gctacttacg tctctccatt tgcccgcaag gaaattcctt gtggacagaa 61740
gacaggcaga gttcaaagtc atccctgtgc tcacatgaga ccaatgcata tctgatggct 61800
tcctccgtcc tattgtttga cccagactag gcatggatgg ctcttcctgt aaattgtgca 61860
ttcagtaaaa ggctaatcaa actcaaaaga atgcagccgt ttgtctcctg tctatgacct 61920
ggaagccccc tcccctgctt cgagttgtct tgcctttccg gaccgaacca atgtacagct 61980
tacacatatt gaggacgtct catgtctcca taaaacgtat aaaaccaagc tgtgccccga 62040
at 62042
<210> 3
<211> 130014
<212> DNA
<213> 智人
<400> 3
tttctctgtc actcaggctg gagtccagca gcgcgatctc ggctcactgc aacccctggc 60
tcccgggttc aagcaattct cttggtactc agccttctga gtagccggga ctataggcat 120
gcgccaccac acccagctaa tttttgtatc tttagtagag acagggtttc gccatgttgg 180
ccaggctggt ctcaaacacc tgacctcaag taatctgtct gccttggcct cccaaagcgc 240
tgggattata ggcgtgaacc accacactca gcctgatatt tgtttacagg tttttctttt 300
gatgtaaaat ttacatacaa tgaaatgcac aaatctttag catatatttg ctgcattttg 360
acaagtgctt acccttgtgt gacccaaact cttatcaagg tatagaatat gaccgttacc 420
ccagaaagtt cctttttctc cttcccagtt aatcttcaag cttccttccc tgtattttac 480
ttgtttattt ctttttatta ttattatttc aaattattta tttatttttt gagatggaat 540
ctccctttgt ctcccaggct ggagagcagt ggcacgatct tggctcactg caacctccgc 600
ctcctgggtt caagtgattc tcctgcctca gcctcctgag tcgctgggat tacaggcatg 660
cgccaccatg ctcggctaat ttttgtcttc ttagtagaga tggggtttcg cgatgttgcc 720
caccttggtt ttgaactcct gacctcaggt gatccaccca ccttggcctc ccaaagtgct 780
agaattacag gcatgagcca ctgtgcccag tccttttttt ttttgttcca gtgaagttag 840
agcaacagaa tacagagtat gtggacaggt tgtgggtgta gttcttgcag aatagaatcc 900
tatacttccg taatatgttt gtatttggtc agaccatggt attcactagc ataaatggta 960
gcatggtatt caccttttgt aatgacttag agtgaggtat ttccattctt ttactcttat 1020
aaataatgtt gtcatgaaca ttttcttata aatctttata catatgcatg attattaata 1080
gtcaaaatag taatattggc caggtgcggt ggctcacgtc tgtaattcca gcactttggg 1140
agaccaaggc gggtggacca ccagaggcca ggagttcaag acaagcctgg gcaacatggt 1200
gaaaccccat ctctactaaa attacaaaaa attagctggg catggtgatg tgcgcctgta 1260
gtgccatctg cttgggaggc taagccatga gaataacgtg aacctggagg taggggttgt 1320
agtgagctga gatcatgcca ctgtactcca gcctgggcaa cagagcaaga ctctgtctca 1380
aaaaaaaaaa ttagtaacat cttcttttat ctgaaccaga tgaaactttg gttctttaat 1440
ggcatgaact ggtcaaagtt tctcacaggc cctgtatttc caattaaatt cagtgctcga 1500
atgacatcca gaaacctgca cagcttgcag ctctctgcct gaagaggcaa catccgtcac 1560
tgggtggcct ggtcctgagc ccttggcaat ttgagggtgg gcgttttgct caaagacaat 1620
tgctaaggct atatggaata tctggtgact gttccatcca aatagaggtg tctgaccttg 1680
tttctttccc agaggctgaa attggggtcc taaggtgaaa tccagttgta aattactttt 1740
tctttatttg gaatgtgaaa tgaaaaatgt attcttgagg ctgggtgcag tggctcaccc 1800
ttgtaatccc agcattttgg gaggctgagg caggcagatc acctaaggtc gggagttcga 1860
gaccagcctg aacaatatgg tgaaaccccg tctctactaa aagtaaaaaa ttaaccaggt 1920
gtggtggcac atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcacttgt 1980
gcccaggaag cggaggttgc agtgagccga gatcgcgcca ttgcactcca gcctgggcaa 2040
caagagcgaa acaccatctc aaaaaaaaaa aaaaatgtat ttttagtcta accattgaca 2100
tatgtatcat aaaaaacaag caagctagat ttctcaacaa aggttctcta agcaaggaat 2160
acacagacgt tactctttct ctgcagcctc tttcaggatg ggggactttg atattgccat 2220
acattcctct tagaaatcat cttaatttgt tattttcatc tactctagtg ggaagataaa 2280
atcactacat ggcagagcca ggagtttcag gcccatttgg ggatttcctc aaggatatct 2340
tataaatgta aatttgctgg ttattcatat gtattgctta attgccttcc cgtctcccca 2400
gtgattatgc cagctaccac cattattact aaaaaggtta acttttttta agcaattcat 2460
ttttctgaac tgtgtattag tttgctaagg gatgtcatag caaaagaacc aataaacaac 2520
ataaatgtat tttctcacag ttatggaggc tggaagtcca aggtgtaggc agagttggtg 2580
tcttttgagg acacactctg tggcttgtag atgatcatct tctcctagct ctgtgtgtct 2640
gcatcctaat ctctttataa agacaccagt cctattggat tagggcccac tcgtatgacc 2700
tcattttact ttaaagaccc tatttccaaa tatagtccca ttctgagatg ctgggggtta 2760
ggactccaac atgtaaattt ggtgagggag cagaatacaa tttagtccat aagaaatcat 2820
aaaacacaaa tatgtaagag aaatgtgagc ataagaaaaa gttaaaaagc tcatacatag 2880
cttcctcagt tggaacaaat caaagtgctt tcttgttttt gccatatgca catctaatta 2940
ttggctctta ctagtttaca ataccaacag caatgcaagt atatgtcagt tttatcacaa 3000
actcagaatt aggtattctt aaaaataaga ttagttatat ttttattgta tttctctttt 3060
aattcagttt cccaatttcc cttaatgaat ttgctaggtt gaaggttttc ctatatatat 3120
ataaatataa ctatatatat acatattttt tttaatagat ggagtcttgc tctgtcaccc 3180
aggctggagt gcagtggcac aatctcggct cactgcaacc tctgcctccc aggttcaagc 3240
gattctcctg cctcagcctc cctagtagct gggattatag gtacctgcca ccacaccggc 3300
taatttttgt ttttttctgt atttttagta gagacagggt ttcaccacgt tggccaggct 3360
ggtcactaac tcctgacctc acgtaatcca cccgccttgg cctcccaaag tgctgggatt 3420
acaggtgtga gccaacatcc ccagccttct ttaatatatg ttatttataa tattggatgt 3480
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ttaaattaat tttctagtag 3540
ttgcctaatc tgtagtgctg cttctaggat ttctattaaa agaatatata ttaaattctt 3600
attaaaggcc agttatgatg gctcataatt aagatgccct aggagcaaca agagctgggt 3660
gggctactga tttccagatg ggaatctggc catgtttata agacctggac ttgaagatat 3720
tgggcagcca acgaggccca tggaggagaa ttctggcggg ctctccactg aagtacacct 3780
acctgctctc accttcaatt tgcctttaat gcctctccac ttgatgttta cggctagcca 3840
cttttaggat ctgagccatc aagatgatgg atgaaattgg gtttggaaca agaaggcagg 3900
gctattttga cccaggacac atttccaaca tgctgtgaag aactctcagc atcaaataac 3960
atctgggtgg aagaagtttt gggaaagaag tctagctgta gatcacacaa tgcttctaaa 4020
tgggagaaaa tgtccagctc catggcttag attctttggg aagtaggata actggctatt 4080
ccattttagg caaggctgcc tggccagaaa cccatgtctt accatttcga gtacattatg 4140
gttggcttac aaatcgtagc ctcatagaga actttttctt cttttagcta ctgtcttcct 4200
aaaataaaag tctctgtgca aagcaatgga agaaacctca tattgttttt tggggttgtc 4260
attttatgta acttacaata atgactacgg ctcgtcttat acaagatgta aaggatttgg 4320
gagagggaat ccagtgtgca tttaggggaa gatggtgatg tagatagcat atttcaggag 4380
gctgggaagt gtcgagtgct taaatatatg cttctcaaat ttaatgggca tacaaattac 4440
ctggtggtat tattaaaatg taacctctaa ttcagtagtt ttgggatggg tccatggaca 4500
gcactttggt tagttcccct tgggactccc ctttcccctc agagaagtgt agagggttgg 4560
ggtattgggc ttaagaggag ttccagactg taaccatagc tctaggtaac tcccttctgg 4620
aagtgatgtg ttagcgactg gaggagaaag ggatccctgg gatccttttc agctttacta 4680
ttctgatttg gggttctgag attccaacaa agtggacttt tgggagtcac agacctccat 4740
gggaatgatg aaagctgcgt accttctttc cgcacaaatg caggcccacc tttaattctg 4800
caaaccactt taggccccgc gggcccgcag ccctggtcca agacagctgt ctgcttcaca 4860
ggtcgcgcac ccagagccgg gcggttctgc agctcagcat ctggcccggg ctgcgcgtcg 4920
ggctctggcg ggggcgtgtc aggaggcgtg tccggggcgt gtcggaggcg gggccaaggc 4980
gggggtaagc ctcgcccctc ggccgtgcga gaggccgagc ttgctgcatt gcagccgccg 5040
cggcgccgct cggctcttca ctcccaacaa tggcggctcc gagcccgagc ggcggcggcg 5100
gctccggggg cggcagcggc agcggcaccc ccggccccgt agggtccccg gcgccaggcc 5160
acccggccgt cagcagcatg cagggtaagg aacgcggccg cgccgagatc ccagccccct 5220
agcgcggcaa cccgcgtcgt cgcggcctgc cccagcggac gcccccggac ccggctgagg 5280
aagccacggc agccgccggc ttctccctct ctccctcccc ggcttcccgc cccgctcccg 5340
gccgcctccg gcccggcttg gatccgggct ccggcccgca taggccccgg ccgcggcctc 5400
tgcctgcgct tggcccctgg gccctaccgg gctctcagca ggcccgcagg gcccacctgg 5460
tccgggaccg cccccgcggc cgtccccatc gcccccgccg cttacctggc gcccgcccgg 5520
cccccgtttc cgggaacgcg ccggctcggg gctgcggcgg agcgggaggg gcgtcgggcc 5580
tgccccctgg tccctgacgc cgctcaggta ggcggcgaag acagcggccc cggccggcgc 5640
ccctcggccc cgccgccgca gtgggccccg ctcagggcca tcttggctgt cgccgggcac 5700
agctggagcc ggaccaccga gctgacctcg ggctacgggg gcctcttgga acctgcgttt 5760
tcaaactttt gcagggtttc tgtgcgctgg aagggatggg ggtggggggc gggttgccca 5820
ggcctgtgcc acctgtaagg taggtaggct gcattggcct gggagaggca ttttgttcca 5880
ggccagggat ttctgtgtta gcattgcgtg caggaagaaa aaaaaaaaaa aaaaaaaaga 5940
agacttaatt tggtttaaat ggagagatac aggaaataga caggggtcaa agtgatactg 6000
tagtgtctgg acatttgagg cagctctgct aattaatgac tttccccact gggaatgctt 6060
attagctgtg tatggctttt gacagggggt gttgtgaaaa taccaggcca ggcccgagcc 6120
tgttagggac catttcctta aatttactgg ggaattttga gtagtaatgc tatttttaaa 6180
acagggaatc tcagaactct cttgacaact ttagcaaact gcttgtgttg aattattaac 6240
agaataaggg ttggggtacc cttggtagtc agtgtgacca tggttacttt ttgattccat 6300
tcctcttaaa gggcttctag catttagtta ggttcaacag acatttattg aatagttcat 6360
gtttatagag catgccataa ttcagaaaga agagacagga ttttatttat ctttacatcc 6420
ctgtcaccct ccccatgaaa taattttaat atacataaaa accagtgata gatatataga 6480
caggatgatg tcagagctta gaggacactt tctgtgcagg ccctcagata attcattcaa 6540
attgaattag ttattggatg cccactgtgt tgcacagcac attatactga tgaagtataa 6600
gattgacttc ctgactgtac agctttacaa tttaggtggt ggtggttggg gcgaaatgaa 6660
atggcaaaat gacaatttag gattgtattt cttgttccag atgggtgact tacaaagctt 6720
ataaaaacaa ggtgatttgt ttgtttgttt tattggtggg gaggctgaca gtttgaaata 6780
gctggataca gtgtgttttt ttggttcaaa aaatatttat tgagcatctg cataaaacgc 6840
tcatgctgag tttatagaga attgaacatc tctaactgtc ctcatggagg ttatccccct 6900
gtgaagatgg gggagggaag gctatttagc taaacatgaa aaattactag ttggaaaagt 6960
aataaaggta acaagctggg ttttgtgata gaagataata gagggcagtc cgcttgataa 7020
gatggtcaga gaaggcttgt ctggaaagct aaccctcttt tacctgaaga cggttctagg 7080
cagaggaact gtgtgtatga aggttccaaa gcagggaaga gcttggagtg ttctaggaac 7140
tcctaaggca gtggttagga ctttttctga tgctgtccgt tctcctcagc ccttgtatgt 7200
tgatacccag ttaactaaac tttctaataa gcagaaccca ttttagaagg aaaaaggacc 7260
taagacctct ctatgaatta ttgccgaatt ttctttttta tcaatattgt gtctagtctt 7320
gattgattca ggaatgtgtt atatcttgtt cttgaaactt ttttcattag tcagaatgaa 7380
gtgcttgata ttctcaggat gttgtctaga acagtctgtt ataaagcttg aacttaagca 7440
gcaatttagg atccttcttt ttggtttgtt ttgttctgta tcttaattgt gaggcccttg 7500
aagaggaaat cttataagaa cccaaaaaga aagattccca tccaattgta tgggagtcac 7560
acctcccata ctgtacttca tctgccaagg gtcttctttt gctttagatc agacttcaca 7620
gagtgggcct tagaagatgt ttgatgtact tccattcctt ctcccccaat ctaattatac 7680
ttgccactca aaaaacttcc tttctgggag ttgttaatga ccatgctctc tgaaacagca 7740
ggattcagtt gtggaacata aggaatgttt catgcagtag acattggaca tcctcttatg 7800
tggtaagcac tgtggtgggc actggataac cttgaatact ttttcatggc ttcatgttta 7860
tggcccaaga gtggtccagg ctggccaata ttgctttctt aatatactgc ttaagaacca 7920
gagctctgga gttctgggtt tgaatctctt ggccaggatt cagatatgcg ttttgtgacc 7980
aggggcaatg aacttggcct ttcgaagcct cagtttctca cttggaaagt gggaataacg 8040
cttacctccc cggtggcttt gagaatgcat gtaagcctgg gacctgacat gtagtaagga 8100
tgcaatacac attagccatc attgttagta gcgacaatat tgttatggtc tcattaatgg 8160
tcccttttac tattggtaaa tgagtcccta acctctcatt atttaccaca caatttcttt 8220
agttcatatt actaggtccc actgttctct ctaacctgtt gatttcccca cttttcatta 8280
ttgagcagtc ctttcagagt atcctagatg agattttatt ctacttcaaa ctccggatct 8340
gtttttttct ggatctgagg actctcaaat gaattacaat gtgaacgata tgaaacagaa 8400
gtctagctat caatttgctc tactcatttt tttcataggg gatgggtaga tggttggaat 8460
gggatttata gtgaatttga ttataagagt aatcaacaga cgtagctttg gttgcatgtt 8520
tatgctaaca gttatggctt ctaatctggc catttttgcc actgtccctc agataatagg 8580
gaatagctgc taattttgtt attactcaaa agatttgagt gtcttcactc attctgactc 8640
attttttttt catgttcatt cacaaacaca cccaaccttt atacgttgag tagttcttag 8700
gctttggttc tttgatgact aaagctaaca aaatgtagat ctgtttgcca agttaggtaa 8760
gtggttttat gaaagtatat ttggcattag gatgagtttg catttgagag aggaaacaat 8820
actcaaatta actactctga gaaatgtttt tattcttaat gtttcatcaa taatttgtta 8880
atgtagatag atttaatagg aaaatttctt gcatattagg gcctcattct gtggaaaagt 8940
attattcttt agtccaagaa attttagcca acctaaagta cggaattgac ttgtagcatt 9000
caagaacctt cctagccatg gctagggctt tcccttgtgg caaatctaaa gcctcgtgac 9060
tttagctggg ttagtgtgaa tcctgtaaag agaagatccc gttataccag gtaattaatc 9120
ttagatatgt atagcaaata gtactagata gtatggttgg catgttagag aatagcatat 9180
tctgattaat agagcttgcc agttgagaat tcaacagctt ctataatgaa attgcatagg 9240
caggatgatt ccttttccag tagtagctgt agcagctagc gttcccatag catgtagtaa 9300
tgtttaagaa acaaaaggat gttgaagtgt aaagagcact ggacttagac tcagaaaacc 9360
atggttaagg taactgctct gctgtttaca aacactgaga ttttagggaa attccctaac 9420
ttttctcaac tctctgttca gaaatttctc atctgttaaa atagggataa tgcctaacct 9480
gtagggccat tgtaagaatc acattcttaa tgcatgtgaa agtgctttga aaattataga 9540
atatctataa gtatatacag attgttatta gacatgatta tttgcctgct gtagctacta 9600
atcacttaaa atgtaataga tttcaaagat cgcttagctg agaaatgtca gttttcaata 9660
gatgttttct taaaatggtt agaatagaat ctataattga ttcagaaaaa cattgagcca 9720
tttgtaaaat acttgttaca agaaatagtt agaaagtata tgttgtaggt gcctctgatt 9780
ctcttaaagt tctgatttac agaaaacttt gtgaccagtc gagtccttag ctatttaccc 9840
ttagctgagc atttttatgt atcagtttaa gtagaaagat gatagcttga ttctgcttta 9900
gaaaacacgc ccagtacttt aaaatgtaat gaagtatatc tgttaagaaa aagtcaagag 9960
atttaaaatc aatgtagtta tttctcccaa aaatatttga atataaaatg tatatgaaat 10020
gtcctgcttt tgattttgtt tatctgtttt tactaattag tctggttttc gagaaccatg 10080
ggagaccttt atcttaattt taaagaactg atttgtgcag acagtgaaga gtttcaaacc 10140
ccagaactgc ttgcccttcc cagtgtgttg cataacattt cttttactgt ttaacataac 10200
ctcatacaag ttcacctcag caaattagtc ccccctcaaa gctcagactg catttcttct 10260
tatgttccct taaaaattag agcaacccta gtattaaagt aaaaaagtgg aaaaacatct 10320
cacctcactt ttagaataca tattttctca cattttcctt taaaatacct tactagcctg 10380
aatgtgtgct gaaacttgtt taagatggga tattagttaa ccctgtattt tgagtcgttt 10440
tcttttttcg taaatttttc ttctttcact aatttgagaa gctggattga tgtgagccca 10500
tagagtttcc ttatttttag gggtctggat atcataatcc taactccatt ctacataatc 10560
gaggtcagtc tcctttgtag tctctaggaa gtgcagatgg ctccaatgat acaacctgag 10620
aaactttaat tgaggcttaa aaaagaaagg gaaagtaaca gttaacaact tttttcactg 10680
ttcctaccta atttgatgct cacaaccacc ctttaaaggt aagtggacat agtccccttc 10740
atagatgagg gggtagacgt ttatttgttc cggaagaggt aggttttaac cacctgggtg 10800
actggtagcc tttgctcctc ttactactct actgcatggt tctctgagcc tctttaagtc 10860
atttcggcca ttcaggtctg aaggaagcat ctttgccaga agtgatgcag attcaggaat 10920
ggaggagaga gattatttta ggtttcagtc agggggcgga agctccaagc aaccagccac 10980
cttttgagat gattttggag ccttggtgct ccaagaatgg tgcacttcat gttacaatgt 11040
tctaaacttg ctggagggtt tacagtggca ttttgaatct ggagacattt cgattgggaa 11100
tctccaagta agtagaagac tttaattaga ggaaaccatt gcagatttga aaggtaatag 11160
aatcctttta acactatata taaaaggaac tcatttgtca taaaatttaa caaatgttgt 11220
cgttctggct aaatttgtaa tctgggcaaa ttactatttt tgctagtgga tgtgggttag 11280
cttctagctg tttcctccca actctagaaa atcttcaggt gtctcttcat gctcggtaag 11340
gttgggagtt taatgtgtac ttaaattaat agaaagtatt caagtcgtaa gactggcctt 11400
gcttgtagct acacagtgaa agggagatga ttagccagta gtttacacaa ctcaaggtgg 11460
gccttttgaa tgaagaaaac aattacattg tatgcagctt ggttctttaa gaacaacaca 11520
ttattctcca ccacggagaa agaggattaa aatggacatc acagcagctt tttcgagcta 11580
tattgtattt cattttaccc aaaattgctc aaacattgaa aaacgaggaa tcaagaaaag 11640
tgttgccaga catatatatc tgaacataca cacacacaca cagacaccaa attgttcaaa 11700
catttaaaaa aagaggaatc aagcaaagtg ttaccagaca tatatatctg agatatatat 11760
atgtcagatg tatatatatc tgacatgcct atgtctattt attgcctggc tttgctgaag 11820
aaatcagtga cattaaggag ctcccctgat gattttggca gtttccctgg gatctggtta 11880
tgtgcctgtc atggggaagc atccatcttt ttggggttgt tagagtcctc aggataccag 11940
gctgtgccta ggaagggttg tggcagaggt gtagagggtg gggtgtggat ctccagggct 12000
gtttggagtc cttccctttt aattctctca aggtgactgt gaatgaaagg agaaagactg 12060
gttttgtgta ggttaagctg gtctggtgag caccagaaag atagggaagg tgccataatc 12120
gttgctccca tgagggagag aacaggaata atagtgcctg tgataataat aacctgcttt 12180
agtccaggct tttggttgga cattttagat atattttccc atttaatcat cacaaagctc 12240
ttttgggtat tattttattt ttcacaaatg aggaaattga ggctcataga agttagatac 12300
ttgcccgaag gaacataatt gtaagttact gtctcagtgt actgtgcttc attaaacagg 12360
cttgagaagg taatgtggca tttaattttg tggccaaaga ataaataagg tggtcattgc 12420
ccaaagagag aaaaagagct ggcattatga ggacacttga atttaaaaag tgtggaaggg 12480
atttgatgag tattttatca actcctgact ggtggatgat tctaacaacc tggaattgct 12540
aacttagggt ggctcccttt tgatagtttc agaaagttga cataaggaaa tctgaaagaa 12600
ataaaccatc aggaaataaa tcttggggaa cttgctctga gtacaatgaa aatacaaatt 12660
tagggtaggt ttagataacg ccttacatgt tagagccata atgatatact atgggtagct 12720
gtggtttaag gcacatgcca gaattttgaa gttggaagtt tgaaggtgtc agacaaatag 12780
acccttcatg cttgtgacag aggaaagact ttgtagcacg gtcttatggg catgacccag 12840
taaggcagct ctgattttct ttacattagt gtgggttcat attgtagttc ataatgcact 12900
ttcagcagtg caaaaatcca gaatgtccag ggaatcagaa gcaactactg aggagatagg 12960
aaaccactta tgtccggccc cacaccctct ctgatttata ttatcaacct agaggaatgg 13020
gaatggagat aactacaaaa cctcataatg gccattacac aagcaaaatt agatttaggc 13080
acactgtttt caaaccctta agataatatt ctttatttaa aaatgacaaa actaggactc 13140
aagtgaaatg acttcagttt cacagttgga actagaactc tggtctccta acacacttca 13200
ttttgttttt tactttatcg aacaccattt gctttttgtt tttataaaca cttacacatc 13260
ctaaacagcc gcttacctca ctgtatttgg taagaacagt aaattgtagg tttcaagtta 13320
tggccacata aaagatctta aaattgaggt aagagggtga gaatgagggg caaatgtggg 13380
aacgagggta ggagatacgt agagagaaaa aggaggagga aaaaccctca tgtagcttta 13440
tttcttttat aggcttacta gcattctgtc ctatgcattt tgatattgat tcatcagtgt 13500
caagaattaa gaatttaaat tcttaaataa atattattct tgatatttat tctaagattt 13560
aattaaactt gcctggggcc aggaaaaatg aaaaagactc aaatttaccc ctacttgtaa 13620
tggggaaaat ataaatggag gatcatgtca aattaagccc cagggtacag atagttcacc 13680
cagatataaa aaagtgaggc acacacgact taaaatgtaa ccagttaact atcaacaggt 13740
tcaacggatt atctagtacc tccagagata ggacttaaag taagtgaata ggaagtcaga 13800
atttcggaga caagggagac ttcaaaaatt gaacatattg gccaggtgag atggctcatg 13860
cctataatcc cataactttg ggaggctgag gcaggaggat tgtttgagac tagcctgggc 13920
aacatgttgg gactccatct ctacaaaaac aaaaaacaaa aaactccaaa agttagccag 13980
acatagtggc ttgcacctgc tgagatgaga ggattgcttg agcccaggag tttgaggctg 14040
cagtgagcta tgatcatgcc actgcactcc agcatgagcg acagcaagac cctgtctcta 14100
aaaaaaaaaa agaaaaaaag aaaaattgaa catatgtgag tgaatactag tgaatattat 14160
atcataacta agaacttgca ttttgtaaag ttgaggatat tggaagtttt cctcattttt 14220
ccttcccacc atctttctct tgtgcaagac tgttgcttgt cccctttgcc catccttacc 14280
ctttgagtat gagctagtgg agctatttgg tactttccca aatctgcact ataagcacta 14340
actttctgac ttttgcaggt cttaaagatt tagacagact aactaaaaac gcttcttccc 14400
taatttaata atgttaagaa agttacagaa ttgctaaaga aaaggtgagc cagtgtgttc 14460
cagttaattt agaccttgct tgtcagtgga ctctgggcga gttaccaagt attttcttag 14520
tgagaaataa tgtggagaga tggatgtttg gatgagaccc cagaattcgt tcacctggtc 14580
acttcataat tagatacaaa gaacaagtct atacttatgc tttgaacatt ttaatcccct 14640
tcccacctcc tttgtagcta cttatataga ttctgtactg gtgacagaat ttcaggtttt 14700
gagaattttt taacacttaa actggcgctt agcttttaat gtgttagagc aatcattggc 14760
gacattctgt cattctcagt cacatatacc ttaaaatttt taatatatta tacacttatt 14820
aagcaatgta acttttttta acacaacctt acatatagat ccaactgatt tctttttcat 14880
ataccttaca aatttgtttt cttgctcctt tcgccatcca tattactatt ttgttcacct 14940
cttctctctc cttttcacct ctttcttttt gctacctagt aacagtcaat cagggtattt 15000
tgctttaaag ttgtttgttt cccagcctcc tctccagttg tagtagaagg tgagttttac 15060
cttccctttt ccagtgggat gcggggaaga cttgcctgct acttccagag aacccttttc 15120
ttcctgaatg tagtcagctc attttgcgtg gtaggaggcc agtggctttt agttgcttag 15180
gcttgtaaga cccatacatc tctgtttttc tttctgaatt ctgttcccac tgcacatttg 15240
gtggggtagc atattgacct tcagtggtag agagaccagg gtcagacctt ctaggtttgc 15300
cctagtactt ctttcccatg aagtctccat tctcacttct tcctgcattg tcatttctat 15360
gataaggtag tcagcagtgg attacttcgg tggtgcacca aagacacttt tcatgtcaaa 15420
gtagctacat tagcattttt cagtttttgt actttataga tggcatcttc ttagaatcct 15480
aagaattttg ataactggat aggaaagact acttaactat cctttcttca gtcctggctc 15540
ttttttctgc gtgttttgat tgaatttgtt taaacacaaa gttattgtaa gcttacttcc 15600
ttcattttgt tccccaaaac acaagcgtag atagaccact aacaaaacca gatatccatc 15660
cactcactaa actaggggtg aaagaatatt ttgtgaaggc ttttgtttta attggcttac 15720
tttactggat gcatcttatc aaaaattata tctgtataca gtgtatacat aaggtgtaac 15780
cagatccaac tggatttgaa aatgtgttta ggtttctaag gggaattcac aggttttctt 15840
cttgtaactt ctaaagtact cagctttctc attcctaggg acactatctt attttttcag 15900
gcctatttta gaagaatttc agcccctctt cagcagttca ttgtcttatt gtttgaagtt 15960
agctaattta ctaggaaatg ttttatgtgt gtgtaagttt cacaatttat gaactgctaa 16020
aacttttgca tcatagatgg taattaatca tgggtaactc taaatcagta atttaagtta 16080
gttaagtaac tcattctgta tttgtaggtt gaaaacattg aaaaaatgga cagaactatc 16140
ttaaaggtta ctgttaactt ctaagggctt gtagttcttt ttattaaata tatatgaaaa 16200
ataaagatta agactgcaac acaatttaaa cttgatttca gtttcatgta atgtattaca 16260
tctacatctg acagagctaa gttttttaag aaagctcatg tgttattgtc tctggtgggg 16320
gtaatgtgat ttgacctgtt cttgaattag ttttattcaa aatttaatat aaaaatgcaa 16380
tgtcatgttc caattttggt ttgtttgatt tacagtaaat gaactggaac ttatcttttt 16440
tactttaggc tttcagataa acttctgtga aaaggcacaa agtaagctac aaattttatg 16500
atattatgct atttattttt ttcatatcca tcttggtatt gggaatgtgt ccactattgt 16560
ttcagctaac cagccatggc aattttacat tcaaagagct accatttttc attcttcttc 16620
caaatattaa aaaaattata ttcttgattg taaattgtac ttttttcact tgaaattgaa 16680
atagcaaaat atgtataggt atttagatgt atataatatg gaaatacgta tttaggtata 16740
gaaaagtata tataggtatt cagacttaac cctaatttaa attacaagta gaagagaatt 16800
cacttttaag atcgtggtgc agaaagtata gagttatatt cagacatctt atgctttaag 16860
attgaattat tataaaccat acattgaata tatttttaat ttttttcttt aaaacaaaac 16920
agtgtttttc ttctgcctcc ctcaccatcc ttattctgta ttaggacact agtcttcata 16980
taatacaaaa cagactttct atatcaaaaa aaaagttata aaccttgtat tttatttatt 17040
gagacagggt cccactctgt tgtccaggct ggagtgcagt ggtgcaatca tagttcactg 17100
cagccttgac ctccctcaag cgatcctcct gtctcagcct cctgagtaac tgggactgca 17160
ggtgcatgcc accatgcctg actgacttta aacttttttg tagagacagg gtctcacttt 17220
gttgcctagg ctagtctcaa actcctgggc tcaagagatc ctcctttctt ggcctcccaa 17280
aatgccaaga ttacaggtgt gagcgactgt acccggccaa aaaaaaaatg catttaagct 17340
taaatgtcat ctgtatcaag tacagttaaa aaaatctcat ctcaaggaga ctactctcca 17400
gttaacataa aaatatacca aaatatgata taagtcgttt tgtcttctgc tttttattca 17460
tgaactggag aagaatgatg ctttgatatg tgtcattctt aagtacattg attcaaaggc 17520
aaaaaaaatt aacctggaaa aaacatttct gctatgttta aatttttttt tggaatgaga 17580
atgcatagtt tccactgatt gattgttatg actactttga aatgtagtta gcaaaaattt 17640
atttcttgaa tggttcaccc acaatgtaac tgtatataaa taatagagat caagcagtta 17700
gaccctagga taaaagtttt tttaattggt tcattactgt tatgtctccc ttgccttaaa 17760
taactgacta aaagtaatat atgatttcct gctcatagtg aacctttata tatgatatat 17820
atctatatga aatgaagtta caacttctgt tttatgcttt taattttgac acattcactg 17880
tgataatttt tagctttgac ttttcaaaat gtctgcttaa tatttagcat gacaacgttt 17940
agcttttatt tgtattttga cctaaaatct aattaatgaa aaaaaaaggc tgtcttctat 18000
ttttgttcat ttcggagaca gagtctcact gtgtttccca agttggagcc cagcctccaa 18060
ttcctgggtt caagtgatct tcccacctca gcctcccaag cagctgggac tacaggtata 18120
tgccaccaca cccagctcat tttaaaattt ttttgtagaa atggaatctt gctatgttgc 18180
ccaggctggt ctcgaactcc tggctttaag cagtcccact tcagcctccc agagtgctga 18240
gattacaggc atgagctacc acacctggcc tgacttttta aaaattttaa gttgtactca 18300
cattattgtt cttttattta acctagttct attgtagata taaaacaaga gaaacattga 18360
ttatagtaaa attgtatata cagtgtctat aagtagcttt gtatgtggat taaaaatgct 18420
tttgaatctt ctaaatggct ctgtttttgt cattatagaa atgataggtt tgcagtgcgg 18480
cctgctttga tacatatgga agaatttaac aatggaggct gggacagcgg aacctgttag 18540
aacttaatta tgtggtggag gggcatatgt attcccactt tgattattca ccttgattgc 18600
cctcactgtc tctttacact gtggctactt tctgctggct tttcacatct ctctttttat 18660
ttctgcctct tcccattgga aggctcctct ttattttcca gttttgggat tcaacacagt 18720
tatttatata cattcacgaa atcacatatt ggacacctag aaaccataca gtaagcgaga 18780
ttcttggtac agaaatgaat ggaataggcc cctgccgtta gcaagctcat agtttagtgg 18840
actagagttg atcctacatt gattacataa gtgttcaacc accgatgtta catactaatt 18900
gatttttaac tggaaccagg gtgaggatgg tgcaggagtg gatctgtcct ggtcaccttt 18960
gctcctgctg ttctctcatg agagagaatg agcataaagg gtgctgagag tctcatgata 19020
actgctttct tgattggaca ctgtgtctta gggatccaac aatgggccta ccctgctttg 19080
gagttaagca gatgtgtctg tgctggctca gacctcagtg aaagactcag ggaatgggag 19140
tgcacacatc agggagggga gctggagact tggtagagat ggctagccct aaattgacag 19200
tatttatttt tgtactatca gtacctatat tttagtataa gttctcagtt gcttacatat 19260
attagcactt cttctaaatc tggtcctgtg atttgcatga cttaaaaaat tagaagtgca 19320
aatctgtaat gtttgcagac aatctgctgg tttgctctgg aatatagaca ttaactttat 19380
ggtaaaagtg gtcacacttt tctttaaaat tgggcttggg ctgggcacgg tggctcatgc 19440
ctgtaatccc agcacttcgg gaggccacgg cgggcagatc acctgaggtt gggagttcaa 19500
gaccagccag accaacatgg agaaaccccg cctctactaa aaatacaaaa ttagctgggc 19560
gtggtggcac acgcctgtaa tcctagctat ttgggaggct gaggcaggag aatcgctgaa 19620
cctgggaggc agaggttgca gtgagccgag attgtgccat ggcactccag cctggtcaac 19680
aagaacaaaa ctccgtctca aaataaataa ataaataact ccatatcaaa ataaataaaa 19740
taaaaataaa ggcttgaaat catcaaagga ctgatttctc cactgttggg gcacacttat 19800
ttctagaatc tccactttta ttctaaggat atttcagaat tatcagataa acttatgttt 19860
aatttattaa aaagaattat gtatcataca gtagttgtag gagggtatgg ggcaaagagc 19920
atgaaattag atatcattca agtctgataa gtctgagtac tggctgcttc aaatgctcaa 19980
atctatcaca aataaaaaag atttattgta agatgattct gatgactaat ggaagctctg 20040
aaggattaat ttttttcatt gactttcaca tagtttttgc tctttatatt gctatgtcac 20100
tctcttttaa tcactttatt acagttgcct gttacaagtc agtggagttt tattggagat 20160
gtgtgtgtgt gtgtttacat gcacaaatag cgattacata tttaatttgg gaaacatctc 20220
tgtagaaatt caataaaaat tcactctgct cctcacagtc ttccttttat agattatagt 20280
tcatgcattt atctattctt cagtttattt tctaaatata agtttatttt agataaaata 20340
aacttcaagt tacatttatt taagaccata gtgtcatgtt tcctttaata ctgttggatc 20400
attgaatttt tctgaagtct gaatgtaaga acactttagg gaaaaaatat ttttccattt 20460
gtaaatgtag agttataagt gtagaggtcc tgccttagaa ggttgattaa tttatctgtt 20520
atttgaagat aatgtttttg tacatgtaaa ggtatttata taatttatga ccgtatctca 20580
ctgactttaa tgagctaacc tgtgaacata gttgtttaga atatgactta cttgctttat 20640
aaaaccattt tttcattttt tatttttcga ggagggatga ggatttgcct gaaaacattt 20700
ttttctcaca agctgcccaa ctaccaaaaa aatcattctt ccaaaacctc ctgatgttga 20760
ttcctcatga agagcagttg agttgcccaa tgtgtgccac tcatgacaga agcccccttt 20820
tttagaaaca cagtttttaa gaaatgcttt tatgaagttg aatttacctt agtgttgtca 20880
gcattctaat tttttttttt ttcagatgag aatcgtgact catttaaaga tctttgggca 20940
taggaatttt cctcagaaaa tgcctaaccg aattgtgtgc taatcagagt gatagtagct 21000
aggcgtttgg caaatactct tctgataatt tatttttcac acaaaggtgc ttttagctct 21060
ttatcactat cctccccccc gccacctttt ttttgtagct gtagtatatt atcagttcat 21120
ggccgaagag ttctggagct ctaaatattt tgggtagtgt taagtttctg tagctttgtc 21180
ttttacgttt ttggtggcgt taaaaacttt gtgcttttaa aaaatgattt aacttggaag 21240
tgtttacata gcaacaggat atttatttag aagattagat gctccagagc tattattctg 21300
gatgctacga attgaaatta gagtacaggt ggcggtggtt tttggtggca ctgcacatca 21360
gtatatttgg aggaaaaaaa ggaggcatcc tggagactga ttttataagt atccctaatt 21420
gttttttaaa ttggtaataa taaaaaggaa accataaaga ggaagaagga tgttttgtga 21480
atcttccaag aaatttggga aagatactaa gtttactgac ctgctaagaa gtgtctgtaa 21540
atgatgatgt tttgacttta ttggagtgga ctataggaaa acaggaaaag caaggagcaa 21600
agggaaggtt aagttgttct gcatttaaaa ctaagaactt agaaaattca gctggttaaa 21660
tttctgattc ctcgttttat gtagcaaaag tctgcagcca gtgacaaaaa ttatataatt 21720
tggaaattat taaattcaac tgagtttgtc agcaatccta agaaacaaaa tgtcatttac 21780
tgctcttgga ggtttataca gtttatataa gtttatatat atagttaatg aagttagttg 21840
aaaaatgaga cttgtaggat tagccgtaag ccagactaac atctaatatt tattaccatt 21900
tgtggggacc atgataaatt gtcaatggga agtccatctg cttggaaaaa agtttttata 21960
ttagttaaag cccaggaatt gtagaagtag aagtggtata ttccagagtc aggattcacc 22020
tattcctctc atactttatg cttatacctt ataccattac aaagggaatg ttgcttagtt 22080
gtctttgacc ttggaaatgg tgggaacatg aatttgtcct gaaaatgctt tttgttgcta 22140
ggagaaggaa ggtttctaac agctattgca ccttaaaata atttggggat gcttaatgtg 22200
tgacattttt gataagaaaa taattagtga ctttcccaca ttgcagaaag ttttcattta 22260
tatgccactt gaactttact actagcaaca aagggatgtt gacagaactt tcagagttga 22320
acagatacag agtagaaatg atatggaacg tttccagaga gtattcccaa ctgaatccag 22380
ttaaagtggt tttcaattta gctcatacat ttagggtgat ggttttcaga taaggtgtag 22440
taaatatttg gattgtcact acatggtttt atgagatccg aatctaggca aaaatgtaca 22500
gttaataaga tgcactaaga aaaagttgtg acttccatct tggtgttcat tttccctggg 22560
tagaaatgcc aaatgaacgt taatcagaaa ggaaaatcaa gtgcgtacga acatattcac 22620
tcccctttag agaagctctt acaaggataa ggaaagagag gtacaaatgt taacagttaa 22680
caaatgtgta tctatatata ccttcgacag ataaagatat taccaatgat aagaagcact 22740
gggatcctta aagatgaatt aaatctagag cctactctga agaagtgtat gttctttgag 22800
agattgagca tatataggag ctatgtggta gaaataataa ctcttaatgt gtgtcaaatc 22860
ctgctctaag cactttatat taactccttt aattctcaca gcagccttat gaagtaggta 22920
taatagttaa tatagatgag gaaactgaag cacagagagg ttaaataaaa tttccaaagt 22980
catatagcta ataaggggca gaactgtgtg accttggtct ggtcacagtt tacacgttgt 23040
aaaccttagt gttttactaa ttcttgaaag cagttggcgc ttataggaat gattttctaa 23100
atcaaatggc ttttgaggag tcctcatttg cactaggtta tgagatctgg acctaccatt 23160
tgtatcttgg taagccattt gtaaggctta tcaaggttat ccagtaagcc ttactgaaca 23220
ttaaagtaga aagattcgtg ttgctatgaa gttaggaaca caggggatct accactaggg 23280
aaaacgatgt ttagtgaaaa cctaaaactc tcctggccta gacagataca aggaataaat 23340
tgctccagga ttctgaaatg acttatatgc ctgggtacag ctggagaaga ttagtaggtc 23400
aggagacctg tgaagtcagt ggacaaggtg gcacagccat gaactttgtg aggacagact 23460
gtgtacagac tgtcataaga acaaactgat gcttttagca aaatttttat gcatccccac 23520
cccactttct ttttggcagg gttagaagaa agatttaatt tttgaaaact tttaatagta 23580
gaaaatttca aacatacaca aaaatagagt agtgtaatga acccccatgt acccattata 23640
tagcatcagc aattaccaac atatagccaa tcttattctt cttccctcca gctatctctg 23700
ctgaaatact ttaaagcaaa ttctgatgat cattatttta tccacataaa tgtgttacat 23760
gtcttctaag tgataaggac tcttaagtac ataaccttga tacaattatc ttaccattaa 23820
atgaacaaaa caatattact agatagctac tcaatgttca catttcccca aaagccttgt 23880
aaatgcttta tttacagtta atttgttcaa gttgagacct cagcaaggta tgtgcacaca 23940
ttgtgtttgg ttgatatgtc tcttaagttt ctttaagtct gtggtaattc cctcttctct 24000
cttttcctta ccattttttt tgtttaaaaa attggttaat ttattttgta gcattttgta 24060
tattttgaat ttagctgatt gcatcctttt agtgtttaac atgttccttc atgccctgtt 24120
atttaccttt aactggtagt tacagaaact tgatcagact tttggcaaga acacttactt 24180
catagacggt gttgtgtgct tcacatcaca tccaggtgtg ttgttgtatc acatcaggag 24240
gcatatgatt tcttgctgga gctcttgtta agataaacca atgggcttag gtgctgccag 24300
tgtgatccat atagtgtaaa gttctccgtc agcctttcat ctggtagttc tggcccatta 24360
actttgccta cattaattat tttcttagga agaggttgac tctcattttc agacatatgt 24420
gggctttgca gatagtagtt gtatccagcc aaaaaaagac aaaatttgtg tttggggcat 24480
acgactgaaa gcaaattata gttaagcctt ggtcatctct gacttaacta tgccagtact 24540
gaaggatatg aaagtgtatt tatatgcaca catatgatat acaaacattt attgggatgc 24600
tctgtatttt gatagaataa aaactggata cttgtccttt ctaccctgga acatgagttg 24660
acccgttcat tagggctcat taatctttgc agataatcaa aagccacgtc aagtaataag 24720
acgttctctg gtgaagttga ggagccaatg gttagacaag actagtcctg ccaaattaag 24780
atcaatccca catcagagcc cagcttttaa aatttgtgtt cagtgcttag aatgctcaga 24840
tccttcaggg cattgccttc ccaatacttg ggaatcagat tgagtcatca aaagtcagtt 24900
tggtgaggat tagaagtgag taagagttct catccaagat ttaataataa aaatctgatg 24960
acctacttgt gttttaatta gtaatgacct tttaatgacc agtgtattgt tgtccagttg 25020
gtgtcattta ccctttagca gtaataattt cttaaccagc tttccttttt tcctattcct 25080
gttccatcat ctaactttaa ctaaattatt aaagtctctc tctcataatg ttctacaact 25140
aatttgctct tttgattttc tttttgggtc tttgtaagta acaaattaga aacatttcag 25200
tcgagattct ctcatgtact gtatacacat gaagtagata gaatgcagca tatcttcttt 25260
gagtgccatt cacgctcttg attattctta atttagtcca accttttaaa actttcaatt 25320
tgtagaatac atttatgggc agcaaatagt tttttattgt gtccactagg aaataaaagt 25380
gtcattcacg tgttaatatt tttgaaattg ggagttattt aatgagggtc aaaagaagcc 25440
atttggatgg gaagaggagt ataatattgc taattattac agtattacct ttgtgtggaa 25500
gatgcctgct cattttctac ctttgttatt tgcttttgta gtgacatagt tggattttaa 25560
tttaaatttg actgtgaatt gttacctaac atttcttaaa aatgattata tagtgaaatg 25620
cagtgctgaa atggaaagtt ggtggagtat acaaaagatc gccacgtctt atgactcatg 25680
gcagttaaaa atgccacata tcgttttcaa agccagaaga tgtctgacta atttttgtgt 25740
catgaaattc tattgttagc atttttctac taaaagcttc tggtaacttt ttcagagaac 25800
ctgcataaca tccagttata catattttga ttaatgagga aaaaaaagaa acaacaaatt 25860
ggacccatca ggaaatacag ataaaacacc ctattgtgtc tcttagtgaa actgtttgtc 25920
ctaaagatgt taaatcaaac atttgagctt cgattcctta tttattgaag aaatatttga 25980
gttcctatta aatgacaggt gctgttacga aaagaactga gttgtcggac tcattagaat 26040
gttctgtctg atttccaatg gtcagaagtc atgccgatgg aggctgggcg tggtggctca 26100
tgcctgtaat ctcagcgctt tgggaggctg aggcagatgg ctcacctgag gtcaggagtt 26160
tgagaccagc ctggccaaca tggcgaaacc ccgtctctat taaaaataca aaaattagcc 26220
gggtgtggtg gcaagcacct ataatcccag ctacttggga ggctgaggca ggggaattgc 26280
ttgaacccag gaggtggagg ttgcagtgaa ccgagatcgt gcctgggcaa caagaacgaa 26340
actttgtctc aaaaaaaaaa aaaaaaaaaa aaaggtacca tgtagtagta acaggttatt 26400
tgaaggctct ctaaatggtc ttaattaaaa tataaacaaa attatgtata tgacttaatt 26460
attcttttgc ctttccggat tcttaaggac agatcatggt gaaaaacagt tattacaggt 26520
aaagtggtgt gaattgtttg ctttgagggt aaagtaattg gtcagttgga caaggtagtc 26580
aggtgtgccc tggagggtgg agagaagtca gcttggaata aaaaattaac tgaacctggg 26640
caacatggtg aaaccccttc tctacaaaaa aatacaaaaa ttagctaggc gtggtggcct 26700
gtaatcccag ctacccagga ggctgaggtg ggagtatcgc ctaagctcgg gaggtgaaag 26760
ccgcagtgag atgtgatcat gccactgcac tccagcctgg gcagcagagt gagaccttct 26820
gtcagaaaac aaacaaacaa aaaactgtga ttcactatgg agtcgaaaag aaggaaggta 26880
gactctctga ctttcctgag ttaggatgat gtggacgtac acactctttg ctttaagaag 26940
atgttcttgg ccaggcgcag tggctcacgc ctgtaatccc agcactttgg gaggccgagg 27000
tgggcggatc atgaggtcag gagatcgaga ccatcctggc taacacagtg aaaccccgcc 27060
tctactaaaa atacaaaaaa ttagccgggc gtagtggcgg gggcctgtag tcccagctac 27120
tcgggaggct gaggcaggag aatggcgtga acccaggaag tggagcttgc agtgagccga 27180
gattgtgcca ctgcacccca gcctgggcga cagagtgaga ctccgtctca aaaaaaaaaa 27240
aagatgttct tgaagtcagg agtctgctag gtatttgaag gacatctggc ttgataatcc 27300
ttgataatat tttcatacct gtttgtaaat caactattga tatatgatgg agaaaaatat 27360
attcataaac catatcttcc tactttatct ctaattcact tggaatttgt tttacttgtt 27420
tttaggcttg tttatgtatt tggatagtta taaaaaccaa ttacaaatat taatggaaat 27480
aaggaaattt ttatttcata tttccaatat tgacaccttg aggtgttttc tgacaccaag 27540
caattctctg acagcaaccg tgtatccaac aattgaattc atttctgaca ctatttacct 27600
ggagttagca tcagatctca caagttgaag ggctcagtgc ttcaagattc tcctcactta 27660
ggatgctagt cacaaatggg gtgtttagga tactcatact cctgcttgga tgacttcaaa 27720
tttgggggtt cccattatca aacttgacca caacccccat caagtttgat aatttgctag 27780
catgtcttat ggaactcagg aaataacttt atttactgtt attggcttta ttataaaggt 27840
tacagctcat gaacagccaa atggaagaga taggaccctg tatagggcaa ggtattggga 27900
gtaaggggac aggggaatag cgcagaggtt ctgtgacctt tccgtgcaca ctatccttga 27960
ttcatttacc aatctggaag ctccccgaac cctattgtta ggggttttta tggaggtttt 28020
attaggtagg catgattgat tgtatcattg gccattggac tccgtctcta gtccttttca 28080
ccttcctgga ggtgtgtgta tgggggcgtg gcagctgaaa gttttaacag tctactcact 28140
tggttgtttt tttctggtgg ccagccccta tcctgaagtt atataggggc cctctgagag 28200
ttaccagact cttgcacaaa gtcaggtatg gttgaaaggg ccacattatc ggtaacaaaa 28260
gacactcctg tcactcagga gattctaagg gttttcagag ctctgtgccc caaacctggg 28320
acaaaggcaa aatacagtta tatttttcat tgtactacag gtacttctgt agcaaaatta 28380
ccttgcacac aattggccca cagctttgaa tctatctggg aaaaagagtg gtaatcccat 28440
aatgggttgt ctactggatt ggtgattttt ctgtcgtgaa aaggatgaac atggtttgtt 28500
tccttggagc aaatgggtac ttaggctagg aagttctctg catcttatag ctttctttat 28560
tctaatctac ttgctaatga agttcatata gaattgaagt gcagaagagt taattactta 28620
tgacttatga ccagtctggc tttcttgtat agttaataac attattactt ataacattat 28680
aaacttgcca agaaggagaa gtcagatctg attgttttga tgtaaggaaa aactcaaact 28740
tttttcctct gctttcacac catacaacaa tcaacataga agactttgtg accaaatatg 28800
ggggatttct ccccactagc aaacaaataa tcacttctgc agcacatacc agctgggtgt 28860
cctccagttc aattatcaca cagcttacct ggagatagtg tcagatccca ccggttgagg 28920
gctcagtccc acaaggctgc ccctgcttca gataccagtt gttaagtctg ggccttcaga 28980
acttctgact gtccggctcc cagttgggtt tcccacaacc ctcctttggg gttaattaat 29040
ttgctggtct ttctggtcac cagccctcat cctgaagcta ggtgctgcca gtcatcagtc 29100
aactcattag catccaaaaa atacatcacc ttggaaattc caagaattta aggagttgtg 29160
tgccaggaaa tggggacaaa accaaaaata tatatttctc aataccatat ttggtagctc 29220
ctcaatttgt gtgctgttgt gagtacttac gtgtcagctg aaatatggat ccccttagcc 29280
ctgtggcctg gggccactca ctagagctct gtgtcattgt ccttgagtca agaacagact 29340
tatatttctt tcattgtgtt gtacacattt tttttttcat atgcacatat aaaaaaggtt 29400
tggaagcact gattgaaaaa atattgatgt tatagttata aaatatggtt aatgttttta 29460
tttcacttat aggtggtgaa cagttgttaa aatagggtgg tgataggatg tcatggcatt 29520
taccaagcag gaaaaataaa tgtgatgtaa gacctgtgtg cacgtggttc cttgctaggg 29580
ttcaagcaag ctgttcttca gagagtatct gatatgtgct tctgtctgta cagtgaggtc 29640
agactagaag ccactccgtg ggctctggga tatagatgga aatcagaaca agccttatga 29700
cttttcttga catagctttc ataagtttgc atattctatt ccttattcca ttagtaagat 29760
tgctactaaa aaaataagca tcagttatgt ggatggtttt ccagaaatct gagtatcttg 29820
ttcttgttac attgtgagac agtaacttaa aactttgggg tgctcatgag gagcttaatt 29880
agaatattga gttggattag gaggcagagg ttatcaaagt ggcctgtgta ttgcaaagta 29940
agagaccact gttgactgtt gtacatagaa aattttgttg gggttgatca atttgggttt 30000
gtgtctcact tgtcttcatg ggatttctgt tgatatactc acaagttcga ggcttaaaaa 30060
cacaaatgcc ctttggattt gccagagatt taggcatcac atggatttaa aaatggtctg 30120
agcacctgga taaaatgctg agtaccttta ctgactcttg ctatgctgca aatgtttcct 30180
cttcctggct agaactctca gcacatgtat agcaatagtg tttctgtgtg aatggaatca 30240
gtgcaggtat gtagcagatt aggccgttct tattaaggac tgtgaaagat gatggtatga 30300
gtgaactctt taaatgagct agggacaaat taaggattca gagaactatt aacacattct 30360
cttctcccct gaaccaaagg tggagataac tggctgcctc cttttgggta tccatttgga 30420
accttctcag agtggttgtg taattgtgaa attccaactc ttaggttccc atgaagtcta 30480
cttgcaaaat cattggaaca tggaattggg gttcgggggg ttatttcgga taagcttttt 30540
atattttgtt ggtgattaaa atgttgttaa atttagcaac attttaaact acagtagggc 30600
cttctttgat tagctggctc cctgggtaat ttttatgggg ttggactaat catgacttgg 30660
ccagagagat tttcaattta gcctgtggaa ttatatattt gcttgttggt agtagacatc 30720
tggctcagag tctgatagaa agtgttgctg ttattggctt taagtgatag ctcaaaggtg 30780
tggctggctg tggaatccca taatgatggc actgtgctta attgatgtga aataactgga 30840
gatcagagag gggctattat aatcaatggc attggtggtt agctgaatca gagaatggat 30900
gaatcagtta tgagtttctg ttaataggtt taaaaggaat ttagggtgtt ttgggagctg 30960
cattccatga agcttcataa accccttatt ttattataac tgaaatgagt taaatttttt 31020
ttttccttgt tagatgagca gcttggaagc gagttttggg cttttaagcc ttccaactct 31080
ccctgaaggc ttttgttaac caaagaagga ctccatacat agtaagaggt agtctacaag 31140
tagaatgctg cttttgcctt tgtctggtgt tctaagaatc tgataggagc tgttaagcct 31200
tttgttgtca aagcagtacc ctttcaggaa ctgatagagg agtgacacaa tccttggtat 31260
tctgggttaa attttttttt tctacccaag aaaaggacta tgaatctttt gccagaggtc 31320
ggaaatgctg agggtgaatt attttgtttt ttttttcctt gacagtagag cctctgaggc 31380
ccgatcctgt cagatgagga aaatgtttaa tatttaggaa tcatggctgt tagtaatcta 31440
cttttaccct ggtttaggac ttggccatca taaatgtaga cagttatcat aattgataat 31500
aaagctggaa tgagtgacta tctagctgac tctgttatgc atagtaatgc ctttactcct 31560
cacagtgccc ctatggggaa ggtaatatta atcccatttg gcaggtatgg cgctaaggca 31620
gagaggtgaa gtcatttacc caagagatat tatatagcta gtaagtagca gagttgagct 31680
tcaaaactag gccgattggc actgctagtc tatattgatt tccctggttt ctagtttaat 31740
agaattagga aggatcctgg attaggatag gaataagatt tttatgggaa agtggtttta 31800
aacacattta caaagcaagc tgaattcttt gttgctaata tattttgttg gtttaaacgc 31860
tatcaaacaa acattttcca gttttcttct ctagagaatt taatactttc tcaattaggt 31920
tttaatatgt acttataact aatatcatag tagttaccac ttttcatgtc tactgtttgc 31980
cactattata gcatatttaa gatatattaa tccttatcac aacagtactg ccaagtagca 32040
gactgttttt atcctggttt cacagatgtg tagtgtacta gaccacagaa atattcttgt 32100
ttgtatcttg attagtgttc cagtggtatt tattagtatt ttcagtggtg atcatttgac 32160
atcttggaaa agaattttct ttcctattcc taccctttaa cctccttgta ctacatttct 32220
ttttcttttt ttttgagaca ggatctcact atgttgccca ggctgctttt gaactcatgg 32280
gcgcaaacga tccttttgct ttggcctccc aaagtgctgg gattacaggc atgagtcacc 32340
atgtctggcc tcacatttct ttttaatttt ttggcagaat gcccaacgaa acagtctttg 32400
tggaggggtc agctacctta tctattgttc atctccactg cctggcatat aacttgtttg 32460
taattgtggt atttctgcac ttgttgttgt gtaaattatt atattgggct ttctaaaaat 32520
ccattttaca cacaaaagtg taaaatgtgc taaaagttgc tgttgggata tttacttgat 32580
ttcttaaact cagaaccatc tagtttccaa aatgcttagc tgtgtggatg aacaacagtg 32640
ctttattgat gagagttcaa agttctgagt gagattttat gaacttttta gtaattgctc 32700
actcttatgt atcaaagatt gccagtgggg ggagataggg gcaatataat attagctgat 32760
agcagctcac ttaatacatg gatatatgga atacctgata ttgcgagtct aacatctctt 32820
tttctttatt tatttttatt tatttattta ttttttgaga cgcagtttca ctcttgtcac 32880
ccaggctgga gtgcaatggc gcgatctctg ctcactgaaa cctatacctc ctgggttcaa 32940
gcgattccat tgcctcagcc tcccgagtag ctgggattac aggtgtctgc caccacgccc 33000
ggctaatttt tgtattttta gtagagacgg ggttttacca tgttggcctg gctggtcttg 33060
aactcctgac ctcaggtggt ccgtccgcct cagcctccca aagtgctagg attacaggca 33120
tgagccaccg tgcctgacct aacatctctt tttcttttga gcttatgaaa tattaggtct 33180
ctcattaccg tagtaattta gggagaaaag agaatgaaag taagttcttt actaccactt 33240
tatttcctca tttctgaaat tgtttgactg taaagttgca tagttggaat tgtgggttac 33300
tcatttcata accagtgatt gcagataatt aaaaaattat tccaggtaat ctttctgttt 33360
tgaaaatgag gtagtaacaa tgagagccaa ggaagaaatg agaatttaaa tgacagctcc 33420
cctctctgcg atgtgatgtt ctgaatactt gtaagtcaaa taccaatatt cttgaaggta 33480
ttctatgaat gacttgtaca ctgcagttcc aggtttctct ttattgtgtg gtggttctag 33540
ggaataccct gtggtgtcaa tgggtgttcc ctaaaaggga ttgattcaga ttgctttttg 33600
attattcctt cctggctcct ttcgcatgtg agtagttgac ttgaaagagc aactgtttaa 33660
tttttatgat tcttttcatt agttgggtgg tagttctgtc tcacctgagc ttgcttatat 33720
gtatttagta ggtctattag gaagactggg actgctgggc cttttgttcc atgtggtctt 33780
tcatcaagga gaatagactg agctgcttca cattcaaact cagggtagct ttccaggagg 33840
gcaaaagtgg aagctgcaag gcctcataaa gggcttagat ttggaagtca tacagtattc 33900
cttctgctat agtattgtgg ttaaatcaag ccccaaggcc agcccagatt caaaaggtag 33960
ggaaatagac ctcacctatt tatggaagga gcagcaaggt ccctttgcag atgggtatgg 34020
actcagggag ctgtggttcc ttggtggtta tttttgtgac aatctaccaa ataacctaca 34080
gtgaactcag cattatatca aaaaggttat actctagagg cagctattgt agatccttca 34140
gtggtcttca ttaccatgaa caatgaagta ctttgctgtt actacaacag atgttaaaca 34200
agggctatca aatatggtga tatcagtgga gttgaagata tgcagattgg ctaaaatgtt 34260
gtagagacgg tttccattct tacaggctgg gtgggaggat tctagtgatt gtagttctct 34320
gattctgacc atacaggtaa cagaatcttg ctttcctgtg atataatgaa acgaaacaag 34380
cccattagat ggcggcaggg ggcagggggc agtgaaatgt tgataagaaa aacaatctac 34440
taataattct aatttaataa atatttgttg aactgctgtt ttgtctgagg tactgttata 34500
ggtgatttgc agagttcaaa gataaatcaa gatagttaaa aatttaaagc agaaaattgt 34560
ttacaatttt ttgatggaaa cagacttgag gatgagagga tggtaaggtg agcccagtgt 34620
aaagtgtttc ttcctgaggg acatactgat gtttttggaa actaaataat gctggctctt 34680
aatagaggaa ctgacacctt ttgctgttct ataaaatgtg aaggagagat gcttttggta 34740
acctagattg cagagattcc atagattttg tattgagtag tggactctca actgcccgtg 34800
ttgaggtttt tggccaagat cgaagcaaac tatatgctca gcttagctgg ttgtggaaag 34860
caatgttaaa aaggtttgta ttgcttgaga agttagtgga gggagaatat tcagggctct 34920
ttatcatctt gtttttaaag ctaaataaac ctggaaggtg tcttccctcc aacttcaata 34980
ttctgtgagt cagtgagttg ctcacaacta gacaaagggt attcctaggc ctcagtgaat 35040
gtggatacac ttgaccaatc cctttcttca ggattacagt tcttaatatt cttgatgatt 35100
ccatgtttgg gagtgctttt ctcatgagaa atttgaggaa gacactgtgt gccgatgctg 35160
tgaaaagctt gtttgaaagg tgctggctgt tctcttaagg cagagttttg aaaccagaat 35220
ttcaaggatg attctgacag attgttgccc tcagccttgg agtggctgag tggggacagg 35280
actgctcaat gcctaggcca gcctctgggc cagctgcaat tctaattttc ccagcatgtt 35340
gaacaaatat tctcatcttt taaacaagcc attgcatgaa aaaagtaggc agtattgctt 35400
tgaggggtgg aacagtgctt tggaagtgtg atgaggacag gtactgttcc taagtcaggg 35460
ttcttggttg caaacaacaa agatttactc cagccaataa ccatataggc ttaagttgtc 35520
tgaggctgtc catgtcaact ttattcccaa atcaataaac atttggaagt gttttctgta 35580
tcaggcacag agctaaggtt ttaggtatac agagaatctc tcgcaggaaa ccgcttctgt 35640
ataaatattt taggatgttt gatgcctcgt ttctctcctg ctatagttaa agggacaatg 35700
tttatctgtg ttgactggtt agaaattgat gatatgacag tcccaccaaa ggggttatta 35760
taatcacaaa ttcataatgt ttttgatcag ttattttaaa ccctgttgta caaatatttc 35820
aatctttgtt agcatctaaa aatcttcaca ggtcatttat agtatcacgt ccctcctttc 35880
tccctgtgaa agttgtttca agtttttgaa aaaaattcat attaatgtcc tatttgcttg 35940
taattttttg tcattaaaaa tatctgaata catggtgaca gattgccttt cggttttgat 36000
ttttttgagg gacccttgaa aaagaagtaa aggagagaag gacccagccc cagtagaggc 36060
tctagtactt agagaaagtg aatgggagag gagaagatgc ctttttttaa aaaaaaaaaa 36120
gctcatgcct ccaggtagcc agaaacagct tctcctgagt attgtaaaag ctatttttct 36180
acttttcttg aatctcacct tcggttgaca ttttggggcc ttccttttcc tcctcaaaac 36240
tgcctttcaa gttcatctta aactgatcag catttgaaga gttggggtac acagatgaga 36300
cccagcaagg taacttgatc atgtgctaag ctcgttggca cttgttttag gctttgagtg 36360
atctttgctt ggaaaggctt cgaaacctac agaattactt agtgtgtttt gttagtaaat 36420
gatcagaata taaatttgga ctttttcaag ataattgcag atgtctctga agtgtagact 36480
gtgtttaaat ctaatttatg taacttaaat cacattctct tcatcatggt gtacgtttat 36540
gaagttaatg gcctttaaag ctttcaattt agtttttatt taaatgtgaa tgcaatgctg 36600
aaaaaaatct ctctgtgtat tcagtataaa tacttatatt caagaaaaca gtttaagttt 36660
taactgttgt aatatatttt attgtttatc tggtaaggtt agctactatt ccgtcaaatt 36720
gggctttcta agaaaggacc aatttttgtt tttctttgga tagttttcac aatagttctt 36780
tgttctgtcc ttgtcttgca ttttatctta gtcttatatt aatttttctt cacacggagg 36840
taatggatga tgtgccagat ggtttcaaac acagactaca tgacatatgc tcagtttttg 36900
atttgaggag tttgtaaaga ttttcttcaa attgtgatag caaagttcct taacttaatt 36960
ttttctgtaa acgatttgcc atattaaggt aattaatagg ttcaagttcc agagattagg 37020
agcttagtat ctttggggac caccattcag cccattacag tctgttttct gggccccaaa 37080
tattcatatc cttcccatgt gcaaaataca tttaccctac cccagcgtct ccaaaatttt 37140
gactcattac agtattaact caaatgtaaa tctcacctaa atattaccag ctcaaaaatc 37200
ccaaatccca ttatgaaaat catttaaatc aggcatgggt aaaactctga gtattatcca 37260
gggcaaattc catttggttt caagacccgg gagtaatcct ctatctttaa atattttcta 37320
aagaaaaatt ctcaagaagt aaaagagcat atttactaaa aaaacctttt tttttgtata 37380
ttgctgaacc tctcacagaa agtttttcta ccagcaatat atcttattag tgattcttct 37440
acctagccat tctgatcatc atgttatcat tatgtatata taatataaaa ccttcaaact 37500
ttgccatttt catatgaaca aaagcttaaa atgtttttgg tgttagtgtc tttttatatt 37560
ttcccttgat ttgtctttac tgctcatatt cttatcactt tttttctatt tttcttgatt 37620
tctatgatgt ctttatatat ttagagctac tgatttttgt attgcaagag ttttcccaag 37680
gttcaatttt tttttagttt tgttttttgg taatatactg agggtttttg tttttttttt 37740
aaatacagtc atatctgcta tgtttcctag tgtacccttt gcacatgttg tttgaatgtc 37800
cttcctctac attatgtgga aaagtcatac tgtactaacc ttatttctga aaatggatgt 37860
gtttggtctt cgtgggaatt cacatgatct ggtagaaagg aggcttatct ttgaaagcag 37920
atctaggggc cgtggcaagg agctctgtgc tcttgtctct ttgccatctt ctccatccag 37980
tgtggctccg tcagattttc agatctcaca tttacagttt gaaccctcta ttaaatcctc 38040
atccactgag gtcagaaagt gtttggattg cagagatatt ttttgagtag ttaattgtat 38100
aataaactct agagagtgag ttcaggaaaa agtgtctcta aggtgaatgt gaaaccaaga 38160
tatgctgcaa atgcttaaaa aattcagttc tgttacaagg tatcctttta agtcctaaag 38220
aaatgattct gtaagactta ttgatataga aagaaatgtt agtgaataaa gcattttaca 38280
aagcattttc atggtctgat ttcaattgta gtgaaaaaat acatgtccct atctatgtat 38340
agaaaaaagt ctgcagtagt tagtaaactg attattttga gatacttgga ttgataagtt 38400
tatgtaaaat tttaacccta tgtattgtat aggtgtatat gtaacatttt taatatattt 38460
gatctttttt tgcattttct gcccttctac catggtggtt ttacttgggt aataaaaaac 38520
attggtatct cttcccttcc taccctaaag aaacagcttc atggaaataa ttatttagaa 38580
tacttgtatt actaacttga agtttactct accgtaatgt ttttagcaaa tttttcagat 38640
tcttcactct gttgtttata ttcattaaaa tgagggaaaa cgatatttat taaactgagg 38700
gcattaagta taacactgaa cagatggtaa tatttttaga atttttcagt atatctactg 38760
agataattga tttttataat agtattttca cttgcaaaag tattaacttc cctgaataat 38820
ggaaacttga agtgatagca ttctatctat tgtatcatag cctagtgaat gatttgtagt 38880
tagtaacaac tttagattat tttatttttt cttagtttaa gaaattcctc attgcctttc 38940
aaaatattgt cctatattaa ctgtttgtta aagcaagttc tcttgccttt tggtgtgact 39000
ttcttatgcc ctcagaatag tacctgtttt gtagtacttg aaacttttac tttttatttg 39060
ttatttctca ggtaaacgca aagcactgaa gttgaatttt gcaaatccac ctttcaaatc 39120
tacagcaagg tttactctga atcccaatcc tacaggagtt caaaacccac acatgtgagt 39180
attcttggta atcaaaggct caactcaagc aaagatttta aagttactgt attttatgaa 39240
tttttccaat tatgagatgt cagtataatt tctctgacta aactctctgg gaatattgtt 39300
tattcttttc cttctggagt tccagttaaa ttgcaagttg catttaggaa atttgactgt 39360
cttctgtcca actgtacaaa ttttcaccac ttagtgacaa aatagagtcc catcttaata 39420
agctagattc ctgcaagatt tctatgtcat agtaaattga aagagttgtg tacatgtgag 39480
tgtacacata tcagtggtta tttcatttac tgaattttta aacaatagaa atgatattgt 39540
agcatcttag tgaaaatatt agagcatctt agttaacata aagcaatacc ttcagaacaa 39600
tattttacat taaccttcaa ttgaatttaa gtgatgtgaa atattaaaaa acctcttctt 39660
atttcccatc ctaacctatc atgaaaatga aggccagtgg ctgtactttt ataaccatgt 39720
ccataaaaat aattttgagc tagtttcgat gttgagaact ataaagcaag tggtgtaagg 39780
tatgattaaa aagctggcag atacattttt ttttaagtaa tttctcaaca atttgcatct 39840
agatcttatt aggcttaaaa tacatttatt cttcccaaag aggcactttt attgctattt 39900
tctcttcttt cagaatttgg tatgcattgt atttacaaac agtaacaaat tggtagaagg 39960
tagtgtcttg caaaagagat gcttaaaata tttttaaaac agcaatgtct agaagggagt 40020
agtttcactt gtagccttag agggaatgaa agatatttta aataaaaagt gtagtaacaa 40080
tttatttttc tcaattgtct attaatttta ttagactggt gttcataatc acacttcttg 40140
tcagagctca gcctagagtc ccactctttt taccttctct gaaacatcaa gtaggggcta 40200
tcttgaggaa ggaaacttag tacttattaa ttagtcagaa tttcagcagc aaggaaacaa 40260
ttcttaaaag aacctccttc cttatttctt agaatttgta gtgaaagcta gtgcaaaact 40320
aattctttaa catagccccc ttctgttacc ttagttacta gctgaaccat atgttggaag 40380
tctaagaagg aaaggatata gcagtaatca ccaaacttat cagatctttc ttttttaaaa 40440
gcctttttgg acaaggagaa agacaacctg acttaaatta aaactggaaa aacattcatc 40500
tatttgtact gtcttccctc tggagtttct ttatgtatgt ggaattcatg gagcaaaatt 40560
ttttaaaaaa tagtaaacac agggtggaaa aaaactttct tccaaagttg agttcaggtt 40620
ttattttttg ttttgttctt aactaatgtt ttataataaa cctatagcca gctagatttc 40680
tcatcctttg tttcttccca gcaagtattt aaaatttgaa aggacatggt aataggtagt 40740
tttaccttat gatagaatct ttagagcttg attctggtat gtaaaaattt tagacccaga 40800
ctttgttgta agttttttat tgtacaggtc aattgttctg ggttaggaat aggtaactac 40860
tagcattgtt actggtcaga gataactgtt ttattactta gaacaacatt atctcctcta 40920
ccttcccagc cccttccaaa aggtatcctt ttgtactctt cctctgagtt gtttgccatc 40980
aagcactaaa aacagttgtt agtttctgtt taggatgagt acttgcaatt agaaaaacat 41040
aacttgtagt ttgtgggagt tttgaaataa gatatctctt aacatttata tgttttttct 41100
cctaaaattt ccttgaactt taataattac agatgtgaat ataaaacttg ttcatgaatt 41160
taggaaaaga taagatgaaa taagcaagct aatgaagtta agatatgtca caggatctgg 41220
tttcagatct ccttggcatt tgatgtctcc tggatgcagg atcctttgca agattaaaaa 41280
aaaaattgta agacagtgtt ctttttttct gagaaccaac agtttaaata aaattccaag 41340
aaatgacaat tggctgtcgt aattttagta aggcataagg taatatggat tgaatgtcaa 41400
attaaaggtg tacaaggggt aaatcatttt agaaaaccta cttgattaaa tgcttcccag 41460
aagaacaaga ttttactgga ttttgaaaga caggcaggga aggttgagtg aagaagacaa 41520
gggacagtgg cattctggtg agcgtatgca caagagaagt tttgggaacc atgtgtagat 41580
ctgtttaatt gtagcaggga tgttatttat agattaccta tttctctctc tcactggaat 41640
cttttagcct gttttcttta ttcttgatat tctgtaatta tatgaggata agcctcaaat 41700
tgcatcatct tcccatgtat cagattaacc cttttagttt caagattcat gtatctcttt 41760
ttctgggaaa attgctgctg ctttcctttt gatacatttc cttcatgttt ttcctatcat 41820
cttctcctga aacttgtgtt actaggatgt tggactgcct atatcccctg tatcctagac 41880
tctaaaaaaa aatgtgttcc gtctcattgt tttcttactc tgtatcctgg gagattttct 41940
ttattttcca tcccctaaat ggaatcttgg caatcagttt taatttccaa gagttgattg 42000
tggcattttc ttaggattct attcttaatt ttggatacaa aatagggaat ttaaaaattc 42060
ttttctgttg tttgaattat tgatttcctc aaggatcagt ttttctttta cctctttctc 42120
agtttttttt tacatcttat aatttttttt tcatgtcttg ttcttgattg tttcttgaat 42180
ggaagctttg gttatagatc atcacctggt gggcttggct ttacttttct gtgagtattt 42240
tgagagctag ctcttaggcc aggaatatta ccaatgctag aattagtaga gccaaaattc 42300
accttaggaa gcctggttct ctccagatgt gtttgttctc tttgaagaca tgcccccttt 42360
ttattttagg ggaagaataa agaggaaaag tggaattaac tagacctttc tttttttttt 42420
ttttttttta agtggcaggg tctcactata ttgcccaggc tggtcttgaa ctcctggatt 42480
ccagggatcc tcccgcctca gcctcccaga gtgctgggat tacaggcatg aggtactgcg 42540
cctggcctag aacttcctta tagaaagaag tttaattaac tctggtttct aggccttcat 42600
ttcttctgac catgaattct ctctgatcca gtgttctatt gggaccatga tttgtccctc 42660
atattcactg catgcctgcc tcctaccatg tgttataggt tatagttttt tctgtttatt 42720
tttaaacctt ttattatgga aaattgcata cctacccaaa agtaaagtgg tagatgaatc 42780
tgtctttact gtcaatcagc tttaacagct tcaacagtta atagcatggc caatgttgtt 42840
ttatcttttc cttcaacccc ttagttttaa ccaaatctca gatgttatgc aatctacaaa 42900
tattttagta tgcatttata aaagataaga gctgctttta aaagacataa tcatagtacc 42960
attgctacat ctagtagaat aaatctttaa tatcatcaaa taagcagatg acctcattag 43020
tttttttatt tttaatagtt tgaagtgagg tctatacaag gtcctgcatt ctatgcagtt 43080
agctgatcag tcttttaaac tagagttcct tctcttgaaa tcgattagtt tttctttgtg 43140
atacattttt atctactcag gcattcagaa atttaattct tttaatttat tgcttatttc 43200
cttaaaaaaa ggatttttgg ggggatcttg gaggatgagg agacaacctg aacaggaaac 43260
cttgattttt aattatcaat gattaaaatt agaaatattt ttgacagaaa atgcatatta 43320
taatagagac tcttgtaccc actaacattt tttcccttgg cttttaaaat gaaagattaa 43380
actggatagc caaagagtac aaagaaaaag caaaggaaaa atgtgtggct accttttaaa 43440
ttttcatcag gtttggattc tactaaacac tataaatctt tttgatactc tagggatatt 43500
cttataaatg tggccagctt gtgttaaaat catgttgtgt atatgaattt gacaaacaga 43560
agtagatatt ctgttaaaca ttctgtgttt tcatgatagt gagttatggt tgagtgctct 43620
cagtgtactg agtcgtttag aatatattca gtacaattgt tattctgaaa gaacatccct 43680
tttatcttca taacatatca caattgtcaa gaaaaaacac tagcttaaaa gttaacactg 43740
gaaataaata gtggtggatg cagataacat tttggggctt aagagttttg gaaccacacg 43800
ttttaagttt aaagtgctct ctttagacca gaggatctct aggatttccc ttatctttgt 43860
ttattacatt ggaacagaca gagactcagt tgtgctatag aacatctagg agtagtttaa 43920
agaggtttca aagtccctag ttaataacta atattcctcg tatttcttga tgagccttct 43980
cagtagaact ttatcttaaa acttagaatt tcttcttctc ttggttaaat tgtgagaact 44040
gtgtcttata aacgttgctg tcttagaatt aatgacgagg ccgggcacag ttgctcacgc 44100
ctgcaatccc agcactttgg gaggtcgagg caggaggatt gcttgagcca agaagttcga 44160
gaccaggctg ggcaacatgg caaaacccca tttctacaaa aatagaaaaa attagccacg 44220
tgtgatggtg tgcgcctgtg gtcccagcta cttgggaggc tgaggtagaa gggtcagttg 44280
agccctggag gttgaggcta cagtgtacca ctgcactcca gcctgtgtaa gagttgagac 44340
tctgtctcta ttaaaaaaaa aaaaaattgt ttttaaaaag aaataacaat gggtagaaat 44400
ttaggagtct ggatttctat cctggtgttg tcgttatctc tgtgtccttg actttatcac 44460
ttaattctgc tctcaattta ggcattgaat tagaatagcg acatacacta ttttatataa 44520
tgaataggaa ggggagagaa ttaagccagc cttgcactgc cttctttaaa taaagtctca 44580
tgtacaaaac tgataggcta aaaagataaa ggaggaactg tgctgactga agtgtttgtg 44640
aggtgggaga gagttttgta gcgttgtctg ccttcattcc ccagaatagt cccaggacat 44700
ctctggtgga tttctaagtg tgaatacctc taatctacat gaatttggaa gtttttttct 44760
gtctctgaaa ttttttgaag caatcatgat actgtgaaat ctctgcattt ctgtggtgga 44820
ccacttttac aaaatagcgg taatggtaga agtatttatg ggtatgtatt aatagatgat 44880
gtttaatctc aaatgtgtta aatactatgg ggtgtgtgtg tgtgtgtgtg cgcgcgtgtg 44940
tgtgtgtggc tggtttggtg ctactgctgc gaatcttttt tcttactgta gtaaatatac 45000
ataacgtaaa aatttttatc ttaaccattt taagtataca gttcattggg attaattgtg 45060
ttcacattgt tgtacatttg tcaccatcat ccatctctag aactttttca tcttctcaga 45120
tcgaacttct gtacccgtta agcaataagt ccttattctc ccttccttct agccctggcg 45180
cccaccattc tactttctgt ctctatgaat ctaactactt tttaggtacc tctcataagt 45240
ggaatcataa caatatttat tttgtgtcta gcttatctca ttcaaaataa tgtcttcaag 45300
gttcattcat gttgtagaat gtatctttct ccacccttct ttttaagggt gaataaatat 45360
tattttattg ttatgtgtat gcagcatttt gtttagccat tcatctgttg ttggacattt 45420
gggttgtttg taccttttgg ctctagtaaa taatgatgct gtgtttggga taatctttaa 45480
agcttagatc attgtacttc ttaatgttac agtttaggga tattcagtct tatctttagt 45540
cccacattcc acctcagtgt acctgaggct gtggtacact tccataagtc agcaattcac 45600
tggagaagtg attctcgaca gaggtggcag tggtaatagg agtggtagaa ctgattttct 45660
ttgtgggccc ctaccccctt gagattcaca ttcccttcaa gctggatgtt tatagctgag 45720
gtggtggatg ctaattctgg aatatgtatt tgcatagatt aatgatacat gctgttgagt 45780
tgtgtgcttt tggtgttata aatcatcttt gttcttgaat cagagactga ggcagacatt 45840
agaagatagc cctggttttt taacccacag tacttctaag tgctgctcct tgaagataca 45900
tctgacttct tagctattga tgagttttcc aaccatttct aatcaggcag ttatgttttt 45960
gagttctgat ttcaatcaga atattataag gccttttatc tttgcagtat gtatgtttct 46020
ggaaactttt atctattatt aaggaaattt gctatatgaa ggtaactttt ttcagtgtgt 46080
ttttttttaa attatctaca actgagtaac agtatgatta tattattgtt cttgagcaaa 46140
tttgttttcc ccagagttaa taactgcctc atatatggtt cactgtgaat cttctctcaa 46200
catagttaaa tacatcagtt ggtcactcag ttctccccct ctcccccccc tttttttctt 46260
tttttgagtt agctatccat ccatactctt gctttaatct ggagtggttg cacttgaggt 46320
ctgcttcaca gggctgttgc cattgttttg tgaatgcctg attctgatta tctgtttccg 46380
ggatttcatc tttttttatt tttcactttc ccactctcat tttggtagag tatatattct 46440
aagtcttcct gagataagaa ttctttctta gtagttttta attatttctc aagctttttg 46500
ggtgtttgta tgcctgaata tgcctttgtc ttttttcaga caggatcttg ctctgttgcc 46560
ctggctggag taaatggtgc tatcatagct cgctgcagtc ttgaaccact ggactcaagt 46620
gattctccta ccttagcctt ctgagtagct ggcactatag gcatgtgcca ccatccctgg 46680
ctcattttta aattattttg tagaggacag ggtcttgcta tgttgcccag gatggtctcg 46740
aactcaagct atcttcctgc ctcggcctcc cagagtgctg gaattacagg catgaaccac 46800
tgcctggcct tgaaaatgtc tttaaataaa taaccctcat aatagatcag cagttttatt 46860
gggtatagaa ttctggggta gaaatttttc tccagaattg tgtttgtatt tcgacaatgt 46920
tttctatttt ccatggttac tttaaaaggt tagatgtgac tttgattcct gaacctttgt 46980
atgtgatctc ttttttcttt tgtgatttat tgtggggatt tttctttttc cccacgttct 47040
gaaatcttgc tgtgtttgca ttcttccccc ccacctcccc tcttcccttt tcccagtctt 47100
ctccctcctt tccctcctcc ccttaccttt ctttttcctt gtagtttgct ctcagtggac 47160
tctttcaatc tagaaaccac tctttcattc taggaaagac aatttattat tattttattc 47220
atctgggatg tgtgttcttc tgacattgct atattgattc agtgaaatcc catcagactt 47280
ttaaaatatg tgtaatgtga cattttgatt ctaaaatatg tatgaaaatg caaaggacct 47340
agctaaaaac aatttgtaaa acagtaagtt gggggactta aaacgacctg atttcaaggt 47400
tatctgtaac acagtcagcc tacaagtaca acctgcaagc tacagtaatt aaggcttggt 47460
ggaaggatat taaggataaa cgaatagatc aatgcaatat aatagaaagt ccagtagaca 47520
aacacacatg tatagtcaat ttatttttga ctgtggtgct tataatattc agtgggaaaa 47580
aaataggctt ttcatagtga tgtaacaaac tggaaaaagg tttgaaagga taaattttaa 47640
tttctacttc ataccatatg caaaaattac ctcaagatgg atcattgacc taaaagtaaa 47700
agcaaaaact ctataaagct tctaaaagaa aacatccaaa atatatttgt tatctggcat 47760
aggcagaaat ttctttgata ggacaaagaa accactaaaa aataataaat tggattttat 47820
caaaattaaa aatttctgct catcagaagt tttttaagaa aataaacagg caaggccagg 47880
cgcagtggct catgcctgta atcctagcac tttgggaggc cgaggcaggc gggtcacttg 47940
aggtcaggag ttcaagacca gcctgaccaa aatggtaaaa ctccatctct actaaaaata 48000
caaaattagc tggacatggt gtcgcatggc tgtaacccca gctacttggg aggctgaggc 48060
gagagaattg cttgaatctg gaaggcggag gttgccgtaa gtagagatca taacactgca 48120
ctctagcttg ggtgacaaga gcaaaattct gtcagggggc ggggggcggg gaggaaagca 48180
gggaggagga gaggggaagg gggggagaga gagagagaga gagagaaaga gactagaaga 48240
aaacattcac aatgtatata tatatatctg acaaaggact tttgtatata taataaacca 48300
aaactcaaaa caacccagtt tacttttttg tttttgagac aaaatctcac tctgtcacca 48360
aagctggagt gcatcatagc ttagcctcca gagtacctgg gactacaggc acattacatc 48420
acacccgact catttaaaaa aattttttgt agaggtggga tcttgctatg ttgcacaggc 48480
tggttttgaa ctctccttaa gtgatccccc tgcctcggcc tcccagagtg ctagtattac 48540
aggcattgag ccgctgggcc agcccaaaga acccaatttg aaaaatggtt taaagactct 48600
gatagacact tcacaaagaa ggcattggaa tggatgataa gtatatgaga aacagccata 48660
agaacattag taataagaga aatgcagact aaaacaaaaa ggtgatacca ctacacttcc 48720
acccgaaggg ctagaattta aaagaccagg caatatcttg gcaaatatgt ggtgtaagca 48780
gaattctcct atattgttga ggaagcagaa aatggtacaa ccactttaga aaactctgct 48840
aggtttttaa taaaatgaaa caagcacctg cccctgaccc agcagtccta ccttttgtta 48900
tttgcctaag atgaaaatac tctcagaaag atttgtaagt gaatgttcat agaaagttta 48960
ttcagaatag ccgccaaatt agaaagaacc cagagtgttc aataatggaa gaatgaagaa 49020
acaaattatg gtatattatt taacaaaata ctcttcctca ataaagtgga gaaaatactg 49080
atacctgcag tcatattgat ggatctctga aaatgctgag cagaagaagc gagacacaaa 49140
agagaacata ctgattctat ctctatgaaa tctagagtag gcagaacaga tctgtggtga 49200
ttgaaatcag atcagtgctt gcctctggag gagattgaca agaatggcac cagggaacca 49260
gggaattttc tgaggtgatg gaatgctctg tatcttgctg tattttgtga aatagaaagg 49320
tgtctgcatt tgtcaaaact cattgagcca catatgctta tgatttgtgc atctcactct 49380
atgtaaatga tgcctcaatt ttaaaagcaa tcctgaacaa taacaattat atatatacat 49440
atattattat tattattatt attattatta ttattggtgt ttgttgtttt tttttttttg 49500
agacagagtc ttgctctgtc atccaggctg gagtgcaatg gtgcgatctc ggctcactgc 49560
aacctccgcc tactgggttg aagtgattct cctgcctcag cctcccaagt ggctgggatt 49620
acaggcctac accaccatgc ctggctagtt ttttgtattt ttagtagaga caaggtttca 49680
ccatgttggc caggctggtc ttgaactctt gacctcaggt gatctgcccg cctcagcctc 49740
ccacagtgct gggattgcag gcatgagcca ctgcgcctgg cctaattttt gtatttttag 49800
tagagatggg gtttcgccat gttggccagg cttgtctcga actcttgacc tcaggtgatc 49860
tgtctgactc gcctcccaca gtctgggatt acaggcttga gccgccgtgc ctggccagta 49920
acaataaaaa ttatagtgat agattttttt actctcactg agcagtattt gtggttttct 49980
gtccttgttc tcaaagcacc tatgtatttc gacaatttag atgacttgat gaatatatga 50040
acactgtgct tttaatgaat tcagctttta tgcctgtgga acaatactgt gataaatttt 50100
atttctgccc atgtggtttc ccctttcata atgtttgaaa gaaccctaga gtgaaatttt 50160
taagaaggtt atcaagtttc ttttgagaat tattctagag tatctgttgc accacatcag 50220
gtatagtgta cccctaagta gctagagtcc cctaaaaagt tgaggggatg tgtttttagt 50280
gtgctttaaa aataacattt actattgttt ctttctttct tttttttttt ttaatacaga 50340
gaaagtataa agaagaaagc caaaatggcc cattatctta tcatccaggt agttcatgtt 50400
accctttaaa aaatcagtag tacctgcttc tggtaagaga attcagttgg tgcagaaagt 50460
tataaaacaa aaaatcagct tcatgccctt aatatttatc tccaaagata accctgttaa 50520
atgtaaaatg ccttgcagaa aagcttatta tatgtcagaa tacataattt atatagatcc 50580
ttaaagaata tttacacaca atagcagttt ttttctgcac ttttttgtag cttgattttt 50640
tattcactta gtaacttagt acatcttgaa aatatttctg aattaacaca tacccttttc 50700
ctcctcctcc tcttcttctt cttctttgtt ttttgagatt ttctcactct tgcccaggct 50760
ggagtgctgt agtgcaatct cagctcaccg caacctccac ctcccaggtt caagtgattc 50820
ttgtgcctca gcctcccaag aagctgggtt ttaggcatgc actaccacac atggctaatt 50880
tttttttttt gagacggagt ctcgttctgt cgcccaggcg ggagtgctgt ggcgtgatct 50940
ccgctcactg caagctccgc cttccgggtt cacgccattc tcctgcctca gcctcccgag 51000
tagctgggac tacaggcgcc cgccactgcg cccggctaat tttttgtatt tttagtagag 51060
acggggcttc accgtggtct cgatctcctg acctcgtgat ccgcccgcct cggcctccca 51120
aagtgctggg attacaggcg tgagccaccg cgcccggccc acatggctaa tttttgtatt 51180
tttgggtaga gatggggttt caccatgttg gccaggctgg tcttgaactc cttgcctcaa 51240
gtgatccacc cacctcggcc tcccaaagtg ctgggattac aggggtgagc cactgtgccc 51300
cacccacata cctattctta gttatatagt attcattaca ttgtataggt gtattatata 51360
tttaactagt tccttattgg tagctattta gattattttc attgttgaat taaaaacaat 51420
gttttagaga acaactttgt gctggtgaaa tgtactttta aaaattaacc aatgtttaat 51480
tcttcataga ttggtaattt tcagcccttt tcttgtcata ggagagactg gaagtagctg 51540
tgttttctcg accttgttac tgttgagata ctagattgga aaattctttg ttgtgggagg 51600
ccgtcgtcct gtgcgtggta gaatgtttag tgacagccaa aatgtctcca gacattacca 51660
aatgaacctt ggagtgcaaa tttgcttctt cttaggacca ctggtacagc gggcactgca 51720
ggtttacaca gatgaacctt tttcctgact gaggagctgc agaagtcaga tataagaggt 51780
gtattccttg gggtttgaat ggatgccaga aaaggggaat ttggggaatg gctataggga 51840
tatctcatag agtccaggga gaacatcaga gctttgggag caagtcatag ttgccagaaa 51900
ccaaagcaat ccagtatgtg ttctttcata catttagcaa atgtttgttg aatgtctgcc 51960
atctgctagt tactatggtg tgggcatagg tatttcatgt tgaaaaaaga gatgtgattg 52020
ttacttcatg aagcttgaga tttagaggca gacacagacg tgtgtgtgta taaaattata 52080
atcacctact tgctattaaa ggaagagaac caggtgctat gagaaaatga aatatgggcc 52140
taatttagaa ggagggtggt gaaaatgtag tcaatgaagg cttctaaact tgagtgagtt 52200
ttactagatt tggggaaggg attgatgagt gttccaagtg gaaggaatcg catgtatttg 52260
aaattatcaa ggtgggaaat attcaacttg tcatggaatg gaaggaatgg cagttcacat 52320
ggagggtgac tgaatgagaa aggaaaaaca aacaaattta gattaagggt gtagagacag 52380
ttaggtatgg agagatgggc cacataatgt agggccttgt agataaagag ctggatgaca 52440
tccaaagtgc agtggggagt tatggaaaag ttgtaagtag gtcagtgatt tacaatttaa 52500
actgattatt tacagtctaa agtaattatt ctggctgccg tgtggactat gtactgaaag 52560
gaggtaagaa tatagttagg gagacctgat aaaactatgg taatgtaggt aaagcgtaat 52620
agtcacctat catgacttca atagtattaa attgatgaca gtacatgtag agagactgta 52680
aagacatttt ggaagtaatt aataaatatt ggtgataatt tgaatgtaga tgatgacaag 52740
gaggaaggtg ttcatagtga cttgtagaat tctggcttga attaatgggt ttagttgcga 52800
ttactgtgat ggagactact gggtatggag catctgtaaa taggggtcat agggcaagat 52860
cgagttttag ataatattta agtttgaggg acctgtgaca ttttattagg gatatcaaaa 52920
catacatata tatattatat atatatatag cgtgtgtgta tatgtattta tgtatacatg 52980
tgtttctgtg cttatgtgca tgtatcacat actctggtgt tgaaaatatg agtctggtgc 53040
cagaagtgaa gttgtagatt ggagataaaa agttgaaaat tgctgccata tagatgaaag 53100
ggttgcctag gaagagagtg agaatgtatt ttgatgagaa aattgtgtcc agggctgagc 53160
cccaagaaaa tctaacattt agaggttgga tagaagagga gggacaggca aaaattaaaa 53220
gatgcttgat aattaggaag caaactggta gtgcatgatg ttatagaaat ctagcattgt 53280
ttcaaagtgc agttgggaag gaattgtggt tggctatgtc taatgttctg agaatgctag 53340
taaagctacc ttgttggcaa aaactcctga gatacacttt aaactactct taatttctta 53400
cttacttggg aagaggtttt agctgccact ggaaattggg gcctaaacag ggaaaggatc 53460
tcatgaaaac atgtaaccta tagatttagg gcagttttcc ttaccttttc ttgaagaagc 53520
atagcccaga aaaactgttc taagggtaaa cttagagtac aactgacaca ggatcagctc 53580
ttaggaaaca gtcaatagca acatgatgca aacatgaatg tttgtcttgt cctctttaat 53640
gttactcttt tctgtggtga taaaacattt ctttgtatgt cataaatcag tactacttca 53700
gaatactgca gacttatcta atttgtctaa tacattctgt tcactaaata tgagtatcag 53760
aatttgaaat tttctattta gaatgtttga gccattcttc tggacatttc atttttcagt 53820
ttttcctttt gcctcatctt agatcacagc aaagatactc atttgttggt agtgccagga 53880
agcaggcagt ttccatggta actgacagac cgagtttact gtggaaattt ccggaattaa 53940
cagagctgca ttgcagaagg atgcataaag cagtattcat ctagagatcg taacagtacg 54000
gacacagaag aacagttgca gtgatgtgca gggtatgtct tacctttatt ttcctgtcta 54060
aggaagatta gtcatatata tatatatata tatatatata tatatatata tatatatata 54120
tatatatata tatatgcatg ctgaggagac agtaaaacag cttggggcgt tttagtatat 54180
gctggcttga tacagtcaaa gttgcttagg aaaaagaagg aagaaatgat ttgggaaaga 54240
aggtatattt gatagcattg ggaagaaatc aagatcagat gatcgaggta gaagaatgtg 54300
atagtgaaat aagaggagaa aacatacttc aaactaatta aataataaaa ggttcttacg 54360
gatagtggtt ctaggcacaa gaagatattt atttatttat tgaaggaaaa tagtagacat 54420
tgtcaagttt gagaaatcaa gttctcatgt gcaggaaaaa gaaatctgtt aagataatta 54480
gctattactt gctgaaagat aggtagatat gagagatgtc caggatatta aacaaggagg 54540
tttgctgcca tcttagcgta cttacctaag tgatgagaga atcctagaag ggtttctgcc 54600
cctaattcca ctctctgttg attggtgggc cattttcaag aaaaattctg aaatgtatct 54660
tgagattaaa ttctggaaac agaactatag gatttgggca gataattgaa ggtgcttatc 54720
atatagagca taattataaa tgtaaaagag aaaaaggata tagaaaatat gatttagatt 54780
atttgcatga tagatgcaat ttaggttgct agataccatt tggtatcatt tatatcatgt 54840
agtcagcaaa ctacagctca tgagctgaat ccatcctgtt tgcttgtttt tgtaagtaaa 54900
gttttattgg aacatagcca cacccatctg gctgcatagt tgcaggagac tagtggcttg 54960
caaagcctaa aatatttgct atctggttct ttacagaaaa aggttgtgac tcatgattta 55020
gatggtgtac tggatttttc aaggcttctg tgagattacc acaaacttgg tggcttaaaa 55080
caacagaaat ttattctctc acagttctag aggccagaaa tctgaaggtg ttggcagggc 55140
catgcttctc ccgaaggttc tgggggagga tccccccttt ctttcagctt ctggtactgc 55200
tgctcttcct tggcttgtgg cagcataacc gtaatctcta tggtcttctt ccctgtgtct 55260
gtcttgtgca tctctatctt ctccttttct ttgtttggtc tcctataagg atagttattt 55320
tatttagtgc ccacctaatc cagaatctct tttttgagat ctttaatttt atccgtaaag 55380
ataggttact ttctgagatt ctggatggac ctatcttttt tttgtgtggt gggtggtgta 55440
tagttcaccc tactacagat ggtattgaag aactgggttt tggcttctta aatcacattg 55500
tatattaagg atagccagtt cttagtgttt cctttgacct gctggagaag atattaaact 55560
cacatttcaa aggcaaggtg atagaggcat agttgaatca tagaagatag cctttgtgac 55620
acaaacataa gcagtagagt aaagggagta ctagaaaatt cataggagaa agagtactaa 55680
aatattcact ggagacggat gaagaccagt gcctgatgct tcatatcgtt ctcttcttgt 55740
ctcttcatat ttttctcacc ctaactccca cctccaaaaa aacaacaaaa tgaatttgaa 55800
attttaatga aaaatggttg gcacaaaaac aaaaatcaca gttttgagga atggctcatc 55860
gctaaattac ggcactggga aatatatata tatgattcaa aagaagtaga cttaataagc 55920
aagtagagga gtggcagtgt agaaggtaca caccaatgta tagaccagtg aacctgagat 55980
ttggcttttg ttgagagcct ttttgtcatt gtgggagtat acaaactatt ggcctgggca 56040
ggagagaagg tctgtgacat tttcctcttc tcatatgggc atatttgtaa accataataa 56100
cagtggtagg tatctatttg cattccctgg aagtctcatt tactgtattt gggtatattc 56160
tgaaatgttt aaaaagtgat gaattcacat ggtgaagaat caaatagtag gcaagggatt 56220
ccaatgtaga cgctggagct gcagagaaaa gccaccttat attgcctata ttctcacctg 56280
cgcactttga aatgaagctt ctgatacaga cttcatggag atgatcatag aagaattaaa 56340
tagaaatggt taatccaaat tagggttcac taagagtaag taagcagttc caaactagcc 56400
taatatactt ttttgaaagt gttactagga ctgtagatca ggagtttgga acagactagg 56460
tgtatcttga tttcaacatt tatgggcaca gaggaggaac atgaagccca atacagtatt 56520
ttcaggaagt ttcttagaag gacaagagtg aagtctgcgt tttctttcta atcaaattct 56580
gttagtctgt gaccatgtat attctgaata tcaaatagga agccatggga atgaaagttt 56640
tcttattttc ttcctttaac aaaacatttg aattgtatgc ctaaatacct tcatagaaag 56700
atacaaattc ccttgaatcc aactacaatt agacttttaa cttttaattt ttctgttagt 56760
gtcatgagta tatgataaga atatcataag gaactagaat aaaatcaggt ataaagcata 56820
gattgggatt aaattgagct ggttgatcat agttcacatg tacaggctaa aatttaagca 56880
gtataaggta ctcatgaata ccctagattt caggtctttg tgttatgtaa aatacacatg 56940
ttcctaaatg tgtctataca taaaatttat ttctataaaa ttgttttcct tttctcatcg 57000
acatgtttaa ataagtgtct caaaaataat aaaagtaagc ttgagggtgt ttaataagta 57060
ggtgttcaaa acacaactca catagtatta agaattagct aacagatcac aaatgaaaag 57120
tagttgagac tcttggtttt taatttgctt taagaactaa atttctgact ttgtaaaagc 57180
aatctgaggt ttgtagtaca aaatgatata tgagtagcag tgtcctgcta aaatatttat 57240
taagaaacaa agatgaaaat atgaaacact gaaaattaag atgacttaac tccctatagg 57300
atctgataat ggatactaat agtaacacag ccagaataag gaaaattttt acccagggat 57360
tcttttatag cagagacttc atcccttttc atgttcattt cttctcctgc ccacactggt 57420
aactaccaga aaaaaactgg ggagagatgg gaagagggag gatgctgatg aattttatct 57480
gggaagtgtc attatgagtg aagtgtacta ggtggaagta gagaaggatt gtagtaacag 57540
tatagtgctg cccagtatag acttaggatt gtatttttat attgctgtta tcagtccaga 57600
atacagtatt agagaccaag aaaattggag agaggagaat ttaccatggg agcagtgagt 57660
gctctgattt gtaatatact aagccttaga tatctcaaat ctgcctttga accataggca 57720
tgtaatgggc aaatccgtat cagacaagta gagtgcagcc caaggataat cttctttttc 57780
tttctctcct tctctcagca gttttattga ggtataattg gcatagaata aactgtacat 57840
atttaaagcg tataatttgc taggttttga catatgtgta catctgtgat gccatcacca 57900
tagtcaagtt aacatatccg tcattcccag aatttcttcc ttctcgttgt agattttttt 57960
tttttttttt tctgagacgg agtctcgtac tgttgcctgg gctggagtgc agtggcgtga 58020
tctcggctca ctgggaacct ctgcctcccg ggttgaagag attctactgc ctcagcctcc 58080
caagtagctg ggattacagg tgcccaccac cacgcccagc taatttttgt atttttagta 58140
gagacggggg ttcaccatgt tggccaagct gagctcaaac tcccgacctc gtgattcgcc 58200
cacctcggcc tcccaaagtg cggggactac aggtgtgagc cactgtgcct ggcctcttgt 58260
tgtagttttt gtgtttagac atttgatttg gttatttttt ctgtcttcca cgtctatatt 58320
taacatactc tatccatcct ttcgtttttt taatatatgg aacgtggtaa atgtttcatt 58380
gtctttattc tagtattttt gtcatttctg gtcagttgca attgattgat gtttttctct 58440
tcactatggg tcatgttttt ctgctttttt gtatactgtg gtaattttag attgcatccc 58500
agagattatt gtgtgatggc tgtttttgta ttttcatgaa tgtttttgag ttttgttctt 58560
tggttaagtt acttggagat agtttgatcc tttcaggtct tgctttttag ctttcgcaga 58620
tgagactact ctagagctaa ttttgcctta ctagtaaggt aaaatccttc taactacttt 58680
attggtttcc aatcaggaag ctttccactc cagtggctaa gaataggagc tgccttgtat 58740
gagcctgggt atcatgcctt cttaatcctt ttaggtggct tattcttcag gcttgtatag 58800
gttcctcaca atcatccgct gatcaaggag ggccctctgc atatcggtgg ggttctcttt 58860
ctgtgtagct gtctcttatc ctgtactctg ccatgtgaac tttggctacc ttggtctccc 58920
tagattccca gatccttgtc cgcaactcaa gggtactgcc aggatcttcc tggatccccg 58980
ctccctgtat cacagttggt gaactcttca gcagtaagct ggggacactt gtagggctca 59040
ccttacatat ttccggtctt tcagtgtctg ctgccctttg tttcctgatg atttccagtg 59100
tcttccagat tgcctatata ttctgtctgt ttttttcagt tgttttaggt atgagggtaa 59160
gtctgtctcc tgatacttca tagtaggaca agtggaggtg ccacattgac actcactgtg 59220
agatggaaac aggaattgtg gaactaggga ataatatctt gaagactttg agaaagagca 59280
tctccaaaca agatatcttg caggattcaa aatagtttct tacaatagtg actgacattg 59340
ttaatacagt gaaagaagtc atggcgttta taaaaatgga ttggaaaaat ctcgaggaga 59400
gaacagactg gatggatacg caacaagatt atagaaaggg ggcagatgag gaaaagacat 59460
aactagggac ctgaaaagca gtggtagagt gaaatccctt ttgatgcaat tgtgaatata 59520
aatgatactg catgacagca aaagaaaaga atttgagggc agtcattgat ttgaaagcat 59580
acaaattact gaatttttta aaaatgtaaa ttcataaaca caagggaagg taaacaacaa 59640
actgggaaaa tatttgcaat gcaggacaag ggttgatggt gttaataggt aaggaacttg 59700
ttagtagaag cagcgataac aaaacaaaca cctgggccag gaaggctcag gggcgctatc 59760
tcaggcagtt aataataata caaaaaagac atatttgttc accagatagc ttaagaatgt 59820
tcaactctag cagttgaaaa gaatgatcta accctaacac ctttcaaatt ggcatgagga 59880
aaaaggtgct gttgactagg tacagtgggc accttttggc tgatagtact cctaaatcag 59940
tgcagacttg gtacacagcc attccagtag tgataaccaa ttatttaatg actgtgttaa 60000
aatatattaa gtgaaatcta taagcagtag gtataatatg ctgtttttgc aacctattcc 60060
catagtatac aaagatacaa aataatatgt actaaattgt taatagtggt ttttttctgg 60120
attatgattg atttttccat tttccttttt atcttctacc tttgtagctt taggagggat 60180
tttagattcg gtgtctggtt ggaaaaagag gttcaagtac tggtactgct gctgaatttg 60240
cacagcaaac acactgcatc taatagaggg tgggagtgaa ggtggaggat gtggctagag 60300
ctgttctaat aaccctactt gactggccac tgtgtttctt tacaaaacaa ggccacctgc 60360
ctatatatga agttccaggc agctttatta gacattgtat agaaatacag cttttctcag 60420
tgtccagtct gattaatgtt ctgggacatt atgtcacagt tctgtgtgtg tgtgtgtgtg 60480
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt tagtctgtag gatttcagaa atttcagact 60540
agtagattag tctgggtcaa tgaagggaca acaactaaaa tacagtagtg ttaattcagt 60600
attaaattta agttaacaga tatatttgtc atttctatcc agaagataaa ttaataatcg 60660
ggaaggactt cactgcaaac atgtagcctc aaaaaattag ttttcagatt ttaatctaac 60720
aagataaatc tctgatatca aaatataatt tctgtacatt gagttgtact tttaataagg 60780
cctgtattat atgaattcat gccctatatt aagtattcta tctataatct tgcatgtttc 60840
gcaaaagtta ggaccattca tatttcactt cttttgaatg tctgtaacac ctgtggcagt 60900
ttttctgggt gtatgtgcat gtgttttctc tagaatgtgg aactgttaag tctctgggaa 60960
ccaagaatta ttagatgtgg aatagtaagg cactgaaatc agggacacca gagttacgga 61020
ttttttgtgt gtttgtattt tgtgtgtgtg tgtgtgtatt ttttgtgtgt gtatcttaat 61080
caaattgtat tgctttattc atgtgttttt tgcagggtac tgtggtatgg actagagaac 61140
ttggaatgac ttatgaagaa accttggaat gacacatgaa ggatgatagg aaagtcattc 61200
tgaggcagga tgctttactg aattgttttt aaccagggta tcaaacatca ggaatgagtt 61260
caggagaacg gaaacatctt aggtgctctg catgttcaga gaaacttctc tagtaatgaa 61320
ctatagaaat gacccctgaa agtatagtct tagagttaag attctattca aggaaatact 61380
tttggcctgt tgctggaact gctctgtgga tttggagaca gttagcatca ttggccccca 61440
gccactaaat gctgcttgca cttcccagtg attgggatga ccaaactgct gctgatgctg 61500
gaggtgtccg ggcactacct cctttgagaa tccctgggaa ataaaataat gctaggggct 61560
gtattaatta aaattaagtt tgtttgcatc taaacaacaa caaggatagg aacaaatagt 61620
ggcttaaacc agatagttta tttcactttt ccatagaaaa gtccggagat aagcaggcta 61680
gggttggtgt agtagcttca ctgttattgg agtcaatgct attttctgct ccatcattct 61740
caggacatta tttcagttct gcagggcatt gagtgtggct ggagctctag tcattaccta 61800
cattccaggc aacaagaagg aggttggagg aaaagaaaaa gagtcttttt tccaactgag 61860
ttagctcctt ttaagtactg tgttcctatt ttccacctct aactgcaagg aatgttggtg 61920
acttagcttg gcctgcaaaa taccacatac taggtggctt aaacaacata atttatttct 61980
cacaattctc gagactggag agtccaagat taaggtgctg gcaaggtagg ttttaacctg 62040
aggcgtcctg ccttggttta taggtggcca cctctcactc tgagctcaag tgacctcttg 62100
tgcatatgag aagagagtga actctgtggt ctctcttctt gtaaggacac taatcccagt 62160
ggattagggc cccacccttc attaaccttc attgaacctt cattatcttc ttataggccc 62220
tgtcttcagt acagtcacat ttggggttag ggccttaaca tgtggatttt gagaggaaac 62280
acagttcagt tcatagtagt tgggaaatgt agccttttag ctgggtgcat tgctgccaca 62340
cataaatgag gatcctgtta gggaggatga agaggagaat ggatgttggg tgacagctga 62400
tagttactgc cacagcggct gttgtctgag tttcccaggt tggtaatgag aaccttgggg 62460
ttggaacctt atgtagtgtt cattggaggc aggtaagggt gatctgtata aaataatgca 62520
cagaaaatta tgaagggaaa gatgagggat atttaggaat tatttttatt ttggggggta 62580
catggtgtat atatttatgg agtatgtgag atgttttgat atgggcatgc aatgtgtaat 62640
aatcacatcg tgggaaattg ggtgtccatc ttctcaagca cttttccttt gtgttacaaa 62700
caatccaatt gtactaggaa ttatttttga taaaatatag tccccattct gaagaaagtg 62760
atatcccaag gaaaagtcag ggaacttttt ttttctttaa gagtataatt gtaggcaaat 62820
atttatgaac aagtaagggc aactttacat ctttattggt ttgtattttt caccaatctt 62880
ctcattgggt gtgttttcta ctgtttatgt tctttctttc ctaggcctct tacgtagttt 62940
aggacagaaa ttgattgact ccagagttta atggaaaggt tctggtccag ttcctgtatc 63000
tagtcagtcc agtgctgtat ctgtgtatag tcctgtggaa gccattgtgg ttgtacctac 63060
tgttaaagca attgctgtga aatggactca gttttgctgg aaagatcgct agcccagtat 63120
aaagacgaat gtatgaacat gccttggtga tgtcataact gtggcatgtt tttctgtggt 63180
ttttacagca ctttttcttt ctaaatgaga aacttggaac tctgggtagg aatcacattc 63240
tcctctttta gcagctttgc tgagatgtaa ttcacatatt ctgcagttac acatttaaag 63300
tgtatagttc atttgctttt agtatattta gtatatttac agaattgtgc atctgacacc 63360
ttattcagtt tttggatatt agcccaagta ggtaccctgt atcacttcgc tttcaactta 63420
ttcagtttta aaaagaaact acagtgagct aaactattag tagagatatt ccataatact 63480
aaaatttgat ctttaaaata agacataata ttgtaactgt tttcattctg taatttctat 63540
atagtaatga aatatctttc atttcagttc tcaagaatgc tagcataagt attatatagc 63600
aatgtagtca tgagagtcat attatatcat ctttaccata ttctcttggt tagaggtaag 63660
tcacaggtcc cactcacacc caaagaaata tgcctacaca aaaatacgaa cactaagaag 63720
gtggggatca tgaggacttc ctggagcctg tctgccacag cccttcaatt agcgaacact 63780
gtaaaaaatt ttgcttctga tttacaagta attttaatta actttttttc agcttccctc 63840
agtggtagat tggtgctgta tatttcacca gtgattttgc cattgagata gtatttactt 63900
gccaaagatt atagaacaat aatcattata catggaactt cttcatgtta gaactttttt 63960
caggcttaat ctgtctactt catgaaaaag attaccaaga agagtttcct atttttgcct 64020
agacctgatt tccatcttaa aagatcagtt ccagcttcat cttcacctaa atggtcactt 64080
atgccactga tttccgggct tcttgtgatt ctggatgcta gagtatcaaa taatatgggt 64140
gaaaggactt tgaactgaaa agcacttgta tgaatgaaag cttatcactt agtatgattt 64200
gaaagtctgt tatttggaac actgatttag taaattgtta tttagaccaa gtgtatgaat 64260
ctttgaagtg taactttgaa ccttaatatt agtacatacg attattctca gagtgggggt 64320
agattttaaa gttctaagtt ttttgggaac cttaaaggtt gctacagaaa accattctac 64380
taattggaga aaactttcct aaattttgga agaagaaaaa taatgaccaa gcacataaac 64440
tttgcttgtt tgcatcatag gatcagagtt taaaagagat cctgatcatt tagtatgaaa 64500
ctgaaaaatg tagttgatat ttaatgaatt ctttcattgt gtgtatggtt gatagtttgt 64560
tcctacacat tggggtttgg tgtgtgtgtg agagagagca agagagagaa acagattgat 64620
tttacatttt tcattggatt tactttttta caaagcatgg ttagaagtta ttaatacttt 64680
gatctccagg ttgagatttt ggagatgatt ttttatttaa tggaaatatg taatgagtga 64740
gctcttttgt ctacgagcca ctcatttttt atcccattgc tttatcgaac gagggctgaa 64800
aatttcaatt ttgaatagca catggcaatt ttcctcttag agccagctag ctattcagtt 64860
aactgttctc ccacctcagg atggtattaa caagaacagg acagtatact aaggcactag 64920
ttcccaaaca ttactggaat catctggggg tctttaaaaa tactgttttc tgactcctgt 64980
ccctggataa ttcagatgta attgctatgg gacgatacct gggcattgag atttttaaaa 65040
tctcccccag gtgattgtaa ggtacagcaa accttgggaa tagttgtact aactgaagat 65100
tgaggcactg gaataactaa tgttgggtaa gatagggtaa gaactttttc gcaataaggt 65160
ttgcagctct tgggattctc acttgataat gctgtttgga taaaccatca tccaagtttg 65220
aataagatct tatatttaga aatgaaaact gatctgcaga attagtttaa tcaataaatg 65280
ggaattttta aaaatcttct tggcaatttg tttttatgaa tcccgttgaa gctgtgtcta 65340
ttgactacct aaatctagat cattcttaat ccagtgtgta aaaaaccagg atgacacaaa 65400
tgaaaaactt caaaaacctg gaggtcagac tattttagta atttagaaaa catttttccc 65460
acacattaat cagtactaaa agaaaaaagt taaaacctat ttaaaatgtg gaaaaattgc 65520
ttcccaatat tttaacagag agagactgag aacacacagc attgagtcat caggaaaact 65580
gaagatctcc cctgaacaac actgggattt cactgcagag gacttgaaag accttggaga 65640
aattggacga ggagcttatg gttctgtcaa caaaatggtc cacaaaccaa gtgggcaaat 65700
aatggcagtt aaagtaggtg atgccatgat tatttttggt actttaatcc attaggtgaa 65760
atttcatggt gcagtaatac cactgttgtt gtgttcctac ttttgtggta aatgtgggtg 65820
tttaaaaaat tgtttctcca actcctttga gggtgttctg tgtagaggtt tcttattggt 65880
ggcacatttt ctatctcttt ggaaacatga gtgtatgaag tgtgcatgtt gattgcattt 65940
ttggcatgat gcattaacat gttttaaact tcaggccctt ctactgccaa ggtgagttca 66000
ggctgggcgg ctgcacccct gggagcaggg cagtgctgca ctgagccagg cgggagctgg 66060
aagaagacgc agcacactgg gttgggcaag gtgcggggct agggctaaca gcagtcttac 66120
tgaaggtttc ctggaaacca cgcacatgct gttgccacta acctcaacct tactcggtcc 66180
tgaccggctc ggcttctgtt tgtttatttc atctctactc agtactgccc tgttccctgg 66240
ttttaaagtt gtactgaaat gcataccttg tgataatgtt gtcacatttt gtccttattg 66300
tgtcgtgcca cttaatatgt tcattaaaaa aaaaaaatgg ccagaaacag agatttgatc 66360
catagacaat acctggcaag cttatgctgg tacctgtaaa gaactggtgg tttccatctg 66420
actcctagtt tcatgtaatt gtaatttatt catttgtttg tttagatgtt taacaaatct 66480
ttgctgtatg taagatattt caggaaaatc agcaacaggg ggaacaactt gcaaaaacaa 66540
aggaaaaaaa gctagctgtg gccataccct ctctgagctt aaaattccta tgggaacaaa 66600
aatgtttcag tttacaagaa ttcagaatgg atttgcatat agtccaagct aatcatcttc 66660
ctattagtgt cctattttga gagtttgtca gagtggttga taagagtcct tagttttttc 66720
ttgacatttg agaatgaatt taaattaaaa taaaatgctt tctgtgtaga agtctgttgt 66780
gagccaaacc ttactgtaac tattttagta tccttcactg ttgagcattt ctttttgctg 66840
ggtcatatga aagtaatgtt aaattagtgg tagggaaaat ttttatgatt ctctctatgg 66900
gttcctaaca ttgtttttgg ctgtattttt aaaatgtggt gagaactata gacttttcat 66960
aggcaggtgt atatacacaa cattttgtat acaaaccgta gacctctaaa gatgcacagg 67020
tgaagaactc tgcattatgt gttaaaataa aatgttttat tggaatgtga aatgatttct 67080
gtattcctat tttgtgccac tgcagtgtaa gtggaaagag tcattttatt tagactcctg 67140
gatgaatgtt gtgttgtccc tttgtgctac ctgtgtgtga catccagttt tagttggctg 67200
gatcttaagg gaaaggtttc ctatatagtt aaagttgtaa acttttcttt caggtactag 67260
ggaaagtaat tttaaaaaat tatttcctgc tttttacagt ttgtgttatg tgtgcttcaa 67320
ctttgttgat gaacattatt aaacatttta gtaatatgga ttgattttag ccattgttaa 67380
aaaggtcata aaggtaaaga gggtacttcc ttttgacact taaaagtttt tctcactgat 67440
taatttgata atattttggg ttgtataatg cttactcaag ttttgtagga attcaagaat 67500
gaaaatagga aattgttgtc catcatttgt aatgttacat tatcagtggc tactggctac 67560
tgtgacagtt ccagttggga tgctattaaa aatcccagct gtacttgaag aactttcaag 67620
gcagtcatga gacctacaaa ctggttgctg tcacatgtat acccaccaca tggtactacc 67680
tagcttcgtt taccatctcg aattcttgaa caagcatagc agttggggat gggagaggat 67740
ggcagtacaa cacatcaatt aacatatagt tgaggagtac ctttggattc catgacttca 67800
ttaatactgg aagaataagt gtttttgcat taatatgcat taaaatttga taccaattga 67860
tgacagatgt atgccatctc tgaattaaag aatgcattta ttattggttt cttcaaagaa 67920
gaatagtctt tcatcacact tgagagagtt cattcattcc tcatttaggt acattgactg 67980
gattgacagg cacaaatata cagaatcaat gtatgattaa ggaggtgttt gatttgagac 68040
tttacggttt taaaggaacc atgagacggt ggttcacaca gctgagagct ttccattgct 68100
gttggtgaaa tgagaaacac gcttgaagta actctgtgct aacatcttaa tacacacttt 68160
gagaataaag aaggattgca ttattagatg ttaagctgga aatgatcctt aagatttact 68220
tgcaatatct gtagaaaagt gaactgtgat attagcttga tttttttctt tgtattattc 68280
ctcattttta gttctgagga attccttccc caaatttatt ttgccatata taagaaatat 68340
ttgaaaaagg tgacttctta gtaaccagag ttaattaccc caaagactta atctaaaaat 68400
cagttttgat ataatcagat ttagtgaggt aacattgtaa gagttatact taaaacaatt 68460
ttttgatgtt tggtttgagg acagtctccc aagctatcgg tgagtttctg cattaggacc 68520
taagatgtga acatggttta ccctttagtt ttaattgcac gtgcttggga aaagggtctt 68580
gctctcctgt gagtgggagt aatttgtata cttgtgcctg aatgactagt cttagggctg 68640
cctagggcaa agccagtgtt gcctctgggg tttcttaaag ctcagggaga acaaccttca 68700
actcttacca gggatttact tctaactgtg atcagtatcc tttacaaata acatttattt 68760
agtgtcctgt tttgcacggt ggtggggtaa ccactgaatg aaaacattag acatgaacag 68820
tcactgtcct ctacataaag taggtgcctg ctcagctctc tggcaggtgg aaatgggaga 68880
ggatggcaat acaacacatc aattaacata tagatgagga gtacctcatc tatatgttaa 68940
ccagctctct ggttaaatgt agcggggtaa agcccagagt tcagaccaaa tgtttgaaga 69000
ggcagttagg attaggtttc tgagctaggg taattcagat ctgggagaaa cacctagcat 69060
catcagtcag aatcaggatg ccacagaaaa tctagggaca caggagaaaa gagagtaaat 69120
gaaatgtcac agcttagacc atgggcttac aagctcagat ggctgacaga gggaagaatg 69180
actgtaagcc tctgatgcct gacagtatat tctccacctg actctgcctg cagtgtaaaa 69240
aatcctgcat gcctagagta ccagcttccc tgttgttttc tagcagactc atgtccagat 69300
tgacttcttg aaggtatgca tgcccttttc atgtttgtag aatatgtgcg aaaaaccaaa 69360
gaaacgtgaa aaagtaagaa tgaaaatgag agggagtata aggactgaag tacctgtcac 69420
taaagatgat ggcaggcagt ggaatctgaa ttgttgtgtg aagggttaat actgtaataa 69480
agctgtcatc tcattgaaga actgaataat attgagcagg taggtgggaa taagaatgtg 69540
tcatgttaaa tttgtcattg tggatcatta tgatgacttt tcagtcttct gcttgagaaa 69600
ttatctgggt taatcaggaa aaacagatct gttgtttgag ggtaggtgca taggccggac 69660
tgagttagca atgtgacctg gtatgcaaga gtttcaagta ttttctttct gttggagatc 69720
tgcctaactt gtcttgttct tttgaacctc agctctaccc tttcacctct actgtttcat 69780
tgatgtgagt cttgctgatt ctggcctgtt aacctgattt tgattcctgc aatcctgcct 69840
ctccttgatt atttggattt tgactttagt gtccttgacc tggagttgag acccagccta 69900
atcctgatgc ttgatagtaa ggactagagc cctctgctga cagtatcagc agcccacagc 69960
tcagctgttc cctgagtaga acggaacttt aatctgctgg ttgagtaggc ctccctggtg 70020
tagatagtat ggtgagtatg ggaagtcagg tatcagaaaa gtatggcttg gcttgttttc 70080
ctgccactgg agagaccatg ccacttctgt caaaagttcc attaccaaat tatttcagtg 70140
gggattatga tgatgaataa tgatttgagg aggttcattt tagtgtttaa acattggtct 70200
tgcatgttct gaaagcacta gaatgatact gggatggcct tcaattggaa aagttccttt 70260
ttgatggcat agagtgcttt gttaggccat tttattcact tccaaagggc cgcagtgatc 70320
atatttgatt atccaaatca cctatgggat gcagatgtca tggctctttt gtttagaatt 70380
gagactgtag tctaatatct taggccgtcg ttcggtcaga tcatgtgact tacttaaggc 70440
atctgtgatt gagctgtatt cttttatgct tcctaatatt gcttaaaagc tgtggtggtc 70500
atatgaaaag tgtaagtaga gcatttccag gaggagacat attcaagggg tgtggcaggg 70560
ctggcctcta ggcagccttg attttgaact caggttgctt atgtagatgg ggttggaatt 70620
cccagtatac atgtgtgctt gttttgctgt cactccaagt taatgttttt cagactgtga 70680
gtttgttcca ttaacagaat tggatgtgca acccaagaaa taaaacagcc aaaatcagta 70740
ctgttcgggg ttatgtgagg gtgggaagca gactctacct gcagccatat tggaagccct 70800
tggggcacca gctctgagga attaataggg gtacaattaa gacagtttgg aaatggttgc 70860
tctaggtgaa ttttagtcaa tcattatatg tttttgaaca ttctaaagat ctggtttctg 70920
aaaccttcta ccatcacttg gttaaactga atgaattttg acattggact aaatcccaac 70980
ttacatagtt atctggagaa aaacctgttt tttgttttgt tttgttttgt tttgttttgt 71040
tttgtttttg agacagtttc actgcgtcgc ccaggctgga gtgcagtggc acaatcttgg 71100
ctcactgcaa cctctgcctc ctgggttcaa gtgattctcc tgcctcagcc tcccaagtag 71160
ctgggactaa aggcacgcac caccacaccc ggccaatttt tgtattatta gtagaggcgg 71220
ggtttcacca tgttggctag gctggtcttg aactactgac ttcaggtgat ctgcccgcct 71280
cagcctccca aaagtgctgg gattacaggt gagagctacc acgcccagcc aaaaacctgt 71340
cttaccatac ctcactctgc gtgggtgtca tttgaaccag tatgtgatat atttcctgca 71400
tattttctat cattctttgt catcttatgg ctatgcctct gaaatttgtt gtatatgtca 71460
gatttctatt gttacctcac tttattgtcg taagtactga aatgatgatc tgtcatttat 71520
ggtcttcaga cccttaaaaa tttcagtgct aagattgaca ttgtttcttt aaatgtggat 71580
gatgtggtta gtaaagagga agaagatgat accactctta ccaaggcatg tcaaacttgt 71640
tccattaact tggtcctcag ggcagctctt cccataatgt aatataacac atgcttttgg 71700
aactgaactc ccaggtgctc tgataatacg tagcagaagg taaggtaaaa ggaattaagt 71760
ggatctcagt atccccagtg agaagaatgg ggtattacta ttaattaatt aattaattaa 71820
tggggctaag atacaactga gagtttatta aattgatttt aaaagacttg aatgattttt 71880
gcaattaaga attagcattc tttcttctgc ccgtagtaaa atcatatatg ctttcacaat 71940
ttaaaataat tgacttaaca gacacttatt ttttcacagg aaagaaagat ttacatctgt 72000
gatcagcatt ctagataatt tgcttgcttc ttttgctgtt tgttttggtt aatgttgcca 72060
tctgctttga ccttattaat gatggctttg tgagatatca tggccatttt cgtgtgtgat 72120
ctatttagaa gactctagct gataaggagg aactcgtacc acaaattagg aaaataagaa 72180
tacctaagat tttctgcagc ccagaggaag gtgataggat attgatgtgc tgctatggtt 72240
tctaggattt tccaactttg gtttctagga ttttccaact ttgtattaca actgaattct 72300
ggacattttt gctgggaaag cagcatattt gtagggttca gaatagtagg gacactggag 72360
gagtgtgatc cttgctctcc tatcctctac atcactgact ttggttgatc tgatgtcaat 72420
cattgactag cagtggattc cccttcacat taatgacagt aaccttaaga gggatcttta 72480
gcagggatta cttaatgaac aatgaagggt atgtttatgg catagcagta ttggtgtttg 72540
tagatcacag aaactggatg cgttttcaaa atattacaac tgtgttgtaa tattatatat 72600
aaattatata taatatatta catataatat atattaaata ttatacaata ttaaatataa 72660
tattaaatat acaatattta atatattatc tataatatgt atgtaatata taatatatat 72720
taaattatat ctaatatata atatatatta aatatataat atataatata tattaaatat 72780
attatatata atatgtaaaa gattaagata atctttgttc ttttcttctt ttgattttta 72840
atgctgaacc tttgctatat cactctttat tttctgtgga gaggaggtcc catgtgctgt 72900
gtttgctcat gtactagttc taggatttct gcatgggtaa ttaaatattt actaatatct 72960
acctggtaca aaaggtggac aactgtcatc atagggagct tttgatttgc ttcttgtctt 73020
gggtgtggtg gttttagcca tcatataatt ggacaggaca attggcaatt acttgaaata 73080
cagaatacag attctttttt tttttttttt ttgagacaga gtctcgctct gtcacccagg 73140
ctggagtgca gtggcatgat cttggctcac tgcaagctcc gcctcccggg ttcacgccat 73200
tctcctacct cagcctcccc agcagctggg actacaggcg cacgccacca cgcctggcta 73260
atttttttgt atttttagta gagacggggt ttcaccgtgt tagccaggat ggtttcgatc 73320
tcctgacctc ctgatccacc tgcctcggcc tcctaaagtg ctgggattac aggtgggagc 73380
caccctgcct ggctcagaat acagattctt ttggtaacct tagatgatag taggtgctta 73440
tgtaggggaa caagccccct gcactgaagt atgggtttta gctaacctag ttatagcaga 73500
ttccacatag attgctgaag agtaaatgcc ttctggtatt ctgattttgg ttggtggtaa 73560
attggaaatg atgctttgcc ttgctaatgg ccaaattact agtagcttgc attattttat 73620
cttgtgtcta tttgttttaa ttggtgcctg gaagaatctc taaagcccta cactgatttc 73680
ctctaatgat tgaattcgtt accttgctga gtttcattgt gtctgagtcc taatttctga 73740
tccaggaact cacctgtctt ttactttgga atactctacc tattcctaac ttctctaagc 73800
agctacaggt gtacctgtgc agcagggaga tgtatctcct actctgctct tactgtcttt 73860
ttatactgcc ctctcggaca ctcagctgag ccatacaaac acctgacaag aatttgtcat 73920
gtgagaattt agagatctgc caggactgat ggtcatgtcc ttccatgtca gttttcccat 73980
ttcttatgct cctcacatct cattcctcca tgcattgtct ccattttaaa acaaaacaaa 74040
aatagcatca gttagaattg atagccattt tgtaagttta tttgattatg ttgctgtttt 74100
caagtgtgtc tgtggcacca ctgctttcta aagtcatttt ctggactcct cagttcttga 74160
ttccttacat gtttgctgat gactcatatc ctttttgcct agaatgttca gatcctagga 74220
actgacatct gtcatgtcct ccgtagaact tctgtttatg aagtgcatat atgacttgtc 74280
atccgatcct tttttactct tgagtctttt gagtatataa tgacctatta ttttcccttt 74340
ctccctgcag gaatgggatc aggtaaccca gagtgcctct tcacatacat tgttcaagag 74400
cttaacttgg taggaaggaa aactgggtta tttgggagaa tcagtagttg tcacatcagg 74460
acaccggcag tcacagaatg ggtcatttca aggcaggccc tggtgctttg ggataaggtg 74520
tgtgctgacc tctctagtaa ctgagatatc tttgagcacc ctaacatgga gatgtaaggg 74580
ttaactctga atcagggtga ctggcaagga ccactatcag aatcagccag gtatttattg 74640
agcatctagg cacaatgcta cttggtgacc tgcttcttag gaactacaac gtgagccttt 74700
attttgcctc gtctgcaact ccatccttag cctttgcgtt gtcagcctgc cttcctttgc 74760
cacacttgag tcttcctaac cttacccctt aatagcaatc acttcatcat catgcgcttt 74820
cccactatcc cttctccctg tctcttccca cccatgaaaa caaatttaga aaatgaaggg 74880
aaataaacaa acaaacaaaa agtcaccatt atgatgggat tgaggcataa tatctgagta 74940
agaagggaat aaattagttt tccttgacag tatatactgc ctgtttctgt ccatcctctt 75000
atttgcttct ttttctttgc tcttccactc cagtccttaa gcgagtttag ttttattcgt 75060
tcctcttgtc ccttttcatg ataacaatgt gtcatagtct gctttaaagt ttttcatact 75120
taccgatgtt agttttattg ctagtcattc atccctgatg agcaccaaca aattgtatgt 75180
gagagatgga tttggtaggg tttggatatg aggctggaga attgtgtcac tgtgaagaga 75240
gagctcccct ggagatctca gtgtaaagtt ggaggacacc tagaacagca ccacatttac 75300
attgttcttc agtatcagta aaagagttat ttatacttta aattcaagtt gttaaaaatg 75360
gaggcattcc acatgaggct aaatattatt caagattttg gtccatcgat gttataagct 75420
gtcaacattt aaatctacca atgacttcca ggtgccatgt tgcacaaaaa gaaggaaagc 75480
agcctttcaa caacttggaa tttgggacat ttctatatga ttgggactgt tcaccaagtg 75540
gatgttgctg tgttttgtga cgagatggag tagaggacaa ggggatcatt tgtaactgaa 75600
catttttagc ttgtcctatg ggacttgtta actttctatt accgcggcct aatccataca 75660
gaactcccaa caactaaatt tgtggctgat ccaaccaatg gcatgagttg gactgacagt 75720
tttagaaaaa atacgctttt tggaattttt ttttaattgg acaagaacca tgcataatat 75780
taatagtctt aaagccagag aactgggaat gtaatctttt tttcctgtgt ctctaagtga 75840
ctctcaattg gagtgatgtt ggcatttctg acctgtatct acctgctgtt tttattggca 75900
tttacctgct ttattgggct tatatgcaat cttgaataca gatttggaca ccaattaaaa 75960
aaaattaact tcaagtttat aaatttcttt actatagaaa actacttata tatgtagagt 76020
agtaattttt gttttgattt tcaatgtttt ctttatgtta tattccaaat aaagtaaaac 76080
ttgaaataat ctgaaaatac tttttattat tgggaaagag atgtggattc tttttcaaga 76140
aacacaattt aattttcctg gaagcgtgta ataacttaag ctaagttagt aaagtagtgt 76200
taagtaaaag agctcagtaa ccccataatg aaaaagaatg attttgaaaa taatataaaa 76260
aacttaatgt tcttgagttg attttcttaa gtattttatg gtttcctgta gttttcattc 76320
tactatttac tgccagggaa aaaaaggttt gctgagctca agtaaacagc cttatctaac 76380
ttttaaattt atataaataa atgaaatttt cctgctattc aaagtttttt atcaatggtt 76440
gttgcttctg aacattatga ttatgaggat ttcaagtcat ataattggcg tcaccttgtt 76500
acttccattt ttctgtgctc ttaaggacag ctttataaag ggaagagaag tttgttctta 76560
ttgatgttca atttttaggt agttatgctc ctttaatgtt agaagatcct ggactcactt 76620
gattcaaatg tagaagtctt tcccatagat attgttttga tggttcatta gaaaaacttt 76680
cttggtagta gctttagtct cttaagtatt ctctaatttg aattgttgat tgtcattatg 76740
tattctactt gagttattta ttgagttatt aaaatcacta atttgaagtt actgctatta 76800
taggcatgtg tttgtagttg atcccctttt ggggtccttt aggccttttg aaatagttta 76860
ttaattcctc acatatgata aatgttacag ttcaacccta aaacattagt ataattaaga 76920
gttagcaggt cggtcacagt ggctcacgcc tgtaatccca gcactttggg aggccgaggc 76980
aggcggatca cgaggtcagg agatcgagac tatcctggtt aacacggtga aaccccgtct 77040
ctactaaaaa tacaaaaaat tagccaggag tggtggcggg cgcctgtagt cccagctact 77100
cgggaggctg aggcagaaga atggcatcaa cccgggagga ggagcttgca gtgagccgag 77160
atcgcgccac tgcactccgg cctgggcgaa agagcaagac tccgtcttaa aaaaaaaagt 77220
tagctgtatt tgttcaattc caaacaattc agatgcaata ccagcagcta cttttctacc 77280
tactgccaga tacttagaca aaatgttcag agaatgtggg gaggtgttga tctcttgaaa 77340
agcacaatca atttcatgtt agactagtag gccattcagc tgctctgtgt tctattttgt 77400
actaaagtga cattaaagaa tacttacaga tgaataggtt ttcctgccag tgctgatgat 77460
ctcaaagata gagctgtgct aggaactctc tacattctga ttagtaacaa ttctgtcaga 77520
gattgtctca gtgttaggta tcagtaagat gttggaactt cagttaggcc tttagatcat 77580
gtagtccata tatcctttct gtagctacgg tagggttttc ggacacaggc tcgctcccaa 77640
aagtcagtta ttgatgataa ctgttgaggt tttgactgta atatgcttcc tagttgaaat 77700
ataaatattt gtacaaatgt gtatttagca taccacacaa ccagttttgt gaaacaaaag 77760
ataaactagt aaagaggaca ccttttaaaa atagtagttt atgtgtgtta gtatatatcc 77820
atttgccaat atattcatac tagtaaaaat agaaaaaaat acatttgtta acacctttta 77880
atagtgagag gtagaaatct tccccaacca aagggttatt tgatttttct tctctacttg 77940
tctctaatat taaacaactc ttcgtctgtt ttaaatttag atatatagga ttattaagat 78000
tcttttataa ataattacct tcctaaatta gcattttcac agctacactt ttagagttat 78060
tttttaaaaa acaggtataa aggtagaata tttacaaaaa ttattacatc atgctttgaa 78120
caaatacaga tcacatctct gggctatttt gacttttaaa aatatccttt ttgagcaaac 78180
atgctgaagt tgatttaaaa gtaagattat taatccataa actatgaaaa taatcaaaat 78240
gagaaagaag ggaaactttc cttaacgtta atagaactag tcttattttg tttccatttt 78300
tcattcttac tttagtgctt gtttatctga gcattgatat ttaatataaa agttgtaggt 78360
aaatctgtgt ctgtaacata gatgccagtt actaaatttt atttgcttat gaaatactgt 78420
aggtagcaag ctgtaaattt taagtagcaa aattaaattt gtttggaata tatggaattc 78480
ctcaaaaatg aaacggagag aacctacttc tgttccttaa acaactgctt attctcatgt 78540
cacatgaaat acatcttcta tatctctttg tgcctctggc ttcttttctg taaaatgggc 78600
tcaagaattt aattgactgc cttcatccct ttcaagaaca tttgacagat acttcgaagt 78660
ctttggaaga caaaatgcca ccttgtgtat tttttgatac taacttgcct tgtaagtaca 78720
cactatgtat tgtacacagt ggcgtgatgt gacattgtga acttttttat gagaacagaa 78780
gttgtttgca tgctttgatg ttaaactata attttattat tattttttta taatttctga 78840
acatgattct ttcctatatt gtccctccca acacctctgt gttctatact gttcctgaat 78900
aagaggtggg aggaggtggg gtacttaatg ttttctggca gtctcttaga aatgtgcaaa 78960
gaaattgttg tacagcttgg ttaggaatat atccctggtc tgcagtatat ggaggagcgc 79020
tttagcacct taggaataga caaaaagagc cctctgtttc ctcagtttta ggttttcttc 79080
cacaggttta tgctgcccta catgctgact catgggttgg agagtcaggt agaacttttt 79140
gtttttaatg tatagaaagt gcagttaaag gacagagtcc caatctagga ttttggagac 79200
ctggattctt gcctggtgca ctgctcctat actagtattc actttatccg gttctggact 79260
atttcccgtc tttatgaatg aggacactgt ggtatgagtg tcctcatgag tgaatgagtg 79320
aagagggatg ttcttgcatt gaatgcctag attgcataca attttgaaac ggtgattaaa 79380
agtatgtata cagctaccta taattattca tatgaaactg ttaaaactca ttatcatttt 79440
ctttatattt gcatgtgggg gttaattttt actgcctaag aactttgttg cataactccc 79500
aacattatta gtaaatgctc atggttaaat tgccctgtct cctttaaagg atttctaagt 79560
gctgtttgtt aaactttctg tgattaaagt aattcttgtg aagtataagg aaagatgata 79620
attttcatat ctggtatttg tgaagtttgg taatttttag tctcgtaacg gtttttctct 79680
accatgagac taaaaattat tggtgttttt gacaaaatta ttgtgttttt ttgacatctt 79740
ttgtcattct tttccagaga attcggtcaa cagtggatga aaaagaacaa aaacaacttc 79800
ttatggattt ggatgtagta atgcggagta gtgattgccc atacattgtt cagttttatg 79860
gtgcactctt cagagaggta ggaataaact gggttttagc tgactaatga atatctaatt 79920
gggacaaatg aagatggcag gattcgattc tattcttaaa tgccatacat tagtaataag 79980
ttaatatctc agtatcttag tgtttaacca tggtaattta catattaact tctgactctt 80040
tttgcggtgg tgggtaaggg gtgaatcaca cgtgtgtttg tgtgtgtgtg tgtgtgtgtg 80100
tgtgtgtgtg tattttagta ttggtggctg tcatttgtaa atctcataca aatattttct 80160
gttctttaag aacctgaaaa atcagctgac ttctaaatat cagcactttt gctatagttt 80220
tagattttca ttgggccttg agcaacgcct cccccccccc cccccccccc cgccgccaac 80280
tttatatttt aacttttact catctgtcat caagtgtatg tctgcattta atataaacac 80340
ttatgtgtcc ctgcccataa tcctgaagta tacccatcag acatggaaat taacaattac 80400
aatataaatt atttttttct aattctctta tccagatttt tgtgtagaaa ctaaagctct 80460
aatttcttgg tctcataatc atgtttcttc ttttggcctc tggttatttt gtgtcccaac 80520
ttgggttatc atttctgcct ccagctctca atccacttac tcatttccag tcatccagct 80580
gcctaaaatg tggaagtgag tttgggctag gggtagaact ggagctgtaa atgaattaat 80640
acattatgat atcctagacc gccatcaaaa attgtgatac ttagttgagt aggacttgaa 80700
ctgaactgct aagcatttca aatactctct aaaaaaaata cctttctcat tttgcaaatg 80760
ttaggatgaa taaccgagtt gttataaact ggtaagaaaa accctcctgc tctcttcttt 80820
ttgggatggg attatagagt gtatccttgg ggtttttgtt gttattggct ttaaaattaa 80880
tatatatttt tgaaacaggg ctgaatgtag cactgagtag aagtatatgc aatcttataa 80940
ttggaaacaa tgttagaggt tagttaattc taaacctaat tctgaagttt ttgtttgttt 81000
ttctgggctc ttactaggta actagtaaca acacattctg cttcatgaca gagcccattt 81060
ctttgttgaa tcactaattg ttaattctca actcgtagtt tttttctatt cctgtcttta 81120
aataatgaga atattcattt ttatgaccag atatactgaa tttattaatt ttcttccatc 81180
atttcacatc agcattccgt tacatcagta tacagtcatg tattcatgtg catgactgta 81240
tcttggacct aaatattatg taatgttatt ctaaatgttt ggaactttct tcatgttgca 81300
caagaatctt accatatctt cctcccttta ttcccaacta tgaacttttc ttcacgatca 81360
ttaaatcatc acaccatatg cagaacaata gttaattagt taattaggga ctgaactaga 81420
ttttctctcc taactagatt ctgtggtcaa ctttttcagt gctgtattcg ttttcattat 81480
agactttccc cagctctgcc tgaaccctaa atcacctcca tagtgctgga atataccaat 81540
ttatttcatt tgttcattta tttaatcatt catgtaccat ttacacacct agccttgggc 81600
tagatagtgt gggaatctga ttgtatgaaa agaaagcaga gtaagtcata ttcatgattg 81660
acaaagatgt ggaaacaaag cacggaagct tggagtggtg tctgaacaat attcccatgg 81720
ttttgttatc atggatagct gagtcacatt tggttttatg tctcagaaag gttgaaggga 81780
gttgacatat gcagctgtaa acactaacgt ctgttgaatg ctttgttgtt ttcacatatg 81840
ttttcttccc agtaatcttc gggatttggt ggtattatct atcccctttt tccagatagg 81900
aaaatgaaat ttagtgtgtt tgacaaaagt tacacagcca acaagtagca gagatgggat 81960
tccagagaca gaaatcttgc tgttccttct attttattag aagtggtcca gatatgaaga 82020
tatatatatg ctttttaaat aagatttttg acaggataag atgtgtgata aggtgaaggc 82080
ttaggaacta cacagttaag ctgtacaaag acacaaaata cctaagtaga tgaaacatga 82140
actttcctcc caaatcagaa tgcagtctgt aataggtact ttctgaataa taagagtttt 82200
agaaaagcag aaagtaacaa cttttacaat agtatgtttt acaataaaaa tatagttttt 82260
caatagtttt acaataaaag tgtagtttta caataaaagt gttactttta ttagtcacct 82320
ttaaagagtg aatagtaaaa gtgtatttcc cgaagttaca aaggttaaaa atattaaaat 82380
ggccgggcac ggtggctcaa gcctgtaatc ccagcacttc aggaggccga ggtgggcgga 82440
tcacgaggtc aggagcccga gaccagcctg gccaatatgg tgacactgca tctttattaa 82500
aaatacaaaa attagccagg cgtggtggca catgcctgta gtcccggcta cttgggaggc 82560
tgaggcagaa gaatcgcttg aatccaggag gcggaggttg cagtgagcca agatcatgcc 82620
gctgcagtcc agcctgggca acagagcgag actccatctc aaaaaaaaaa aaaaagtatg 82680
tgtgtatgta tatatatata tattttcata tatatgtaag taataaacag attgaataag 82740
actttaaaga aacatttttg ttttgcagtt gatgacttaa acatgcatct tttttggtga 82800
catgaccttc agttccaata atagacacaa aatctgagtt catgaaagga aatagtagaa 82860
atgaatgtat gtagtcagga ctttttagct taccttacta tcactgtgag agagacagtg 82920
ctttcaattc ctgttactgt gagacaccct ccagggattt catttcacct aatttataca 82980
accactagac tcagctcttg gtttggttca gtcagccatc catcaaggag cttatgagat 83040
gttccttttc tcattcttgc agcaactatt tatttattta aatttaaatg ttatttaaat 83100
ttaaggggta caagtgcagt ttttttatat gaatatattg agtagtggta cagtttgtgt 83160
ttttagtgta tccatcaccc aaacaatgta aattgtaccc atcaagtaat ttttcatcat 83220
ccaccccgtt caactcctcc ctcccttctg tgtctccaag gtctccagtt ccgtattctg 83280
tccatgtgtg cacatgattt agctccccct tataagcgag aacatgcagt atttgtcttt 83340
ctgtttctgg tttgtttcac taaagataat ggcctccagt gtatccgtgt tgctacaaaa 83400
aaaaaaaaac atgatttcat tcttttttta atggctgtca ctgtctattg tgtatatatg 83460
tcacattttt aaaaatgtgg acatttaggt tgattctgtg actttgctat tatacatagt 83520
gctgccataa gcataccagt gcagatacct ttttgatata atgatttatt tttctttggg 83580
tagataccca gtagtaggat tgctggatca aatggtagtt ccactaatta gagattaatc 83640
ttgctgttgg gtaatattga gcttctgaaa gttccgtcac ttattcaaag cagtgaataa 83700
tccttaatac tgaagttggt aacttctatg ttgccactat cttcaaccat gcatacttct 83760
ttctaggatg gaaccaacct caaaaagaaa agtccaaagt acagcttgga tttggtttag 83820
ataagttatt aggtcactca gttgcacagg ttcctaaaag tcattttcag gctttgtagg 83880
taggtggaaa aaagagcttg ataataattg aataatggaa gtaactttta gcctatattt 83940
tacaaaaaag acctaccatt tatcttaaca gtgctgaaac ctagtatcac ttaaaaattt 84000
ttctaataca taaaatttga gaatttcata gcaggtaaac tcttatttta aacatctttt 84060
gaggttgggc aataaattct agtgcagaaa gcactgttct gagtaacttg tgaatgtaga 84120
agttcatcag attatagaag gcagtgatgc tggctgaagc aagttacctc cccctttttt 84180
atccttactt ccacccctct tctcctttcc ctcttctttc tccttgcaag ttttaaatgc 84240
agcttatgga ggtaaaattg acatctgata aacttcccac atgtaaagtg tacagtttga 84300
tatgtttgaa caaatgtata cacctgtaga attatcacca aaatcaaggt aatgaatatg 84360
cccatcactt acgagtttcc ttacaccacg taggtaatac ctgccacctc tctgctgtcc 84420
ccattctcag ataaccactg acctgcttta tgccattata gattaatttg tatttttcta 84480
gattttatgt aaacggaatc ttacagtatg tacttctctt tttcagtttg tcgtctttca 84540
ttcagtataa ttatcttgca tttatcagtc atttatttct ttgtattgcc aagtactatc 84600
tgtaatgttc cattatgcag atctatcagt ttgttactca tttacctgtt gatggccatt 84660
tggattgttt tcagtttttg tctgttacta ataaagttgc tttgagcatt tatgtacaat 84720
tgtttgtaca taagctttta ttttcctggg gtaattacat gggggtggaa tggctggatc 84780
atatggtagg tgtatgttta actttttaaa aaatggacaa acttttttct aaggtagttg 84840
taccatttta tactttcacc agtagttttt gagagttcag cttcttccat gtctattcca 84900
gcacttagtg tgatgtgttg tgttaatctt tagccgttct agtaaatgtg tggtggaatc 84960
tctgtatttt taatttgcat gtttctaatg actaacagtg ttgaatgtct tttcatgtgc 85020
ttatttacca accgtatatc tttgatgaag ttcctgttaa aatctgttgt acatttttat 85080
ttaaattggg tttttttgtt attcggtttt gggaggtttt taaaaatgtg ttttgaatac 85140
aagtttatta tcagacctat gatttgcaga tactgtctcc tgtctgcgct tatctttata 85200
tatatctatt cttcacagtg tttttggaga gcaaaagttt ttaatgttga tataggccaa 85260
tttttaaatt tgtgtattgt gcttttgatg ttgtgtataa gagctcttgt ctaactcaag 85320
ctcacttaag attatctctt atgtattctc ctagcagttt tatagtttta ggtatcacat 85380
ttatacttat ccatttggag ttagttttta tatatatcga gagttatata ttgatgattt 85440
ttttttgcat gtggatatcc tttgcacctt tatcagatat cagttgtcca tacagatgtg 85500
tgtctatttc tggagtatct gctctgttcc attgatctgt tgtttttctg tctttgcact 85560
gatctcacat ggtcttggac tactccagct ttatagaaag tcttcagatt tgagagtgtt 85620
ggtccttaaa ctttgttctt ttaaaagttg tttcggctct ttcatatcct ttctattttc 85680
atgtggattt tagaatccac ttgtcgattt ctaccaaaaa acccgaaaaa aaccaacaac 85740
aaaaaaacaa cctgctgaaa tttttattgg gatttttcta atttgtaggt ctactggggg 85800
agcattgata tcttaacagt attaagtctg ttgacccttt tttgtggcat ctcactttat 85860
tattttacat cttctttaat ttttctcagc aatattttat agttttcgct gtataagtct 85920
ttcatgcttt tgctagagtt gcccttaagt gtataatatt tttaatgcta atacgtattt 85980
ttaaatttaa ttttctcatg tgactaaatg cacaaatatc atttgatttt tttatattga 86040
tcttgtgtgc agcaaccttg ctaaactcaa attccagtag ctttttttac ctgccttcag 86100
atttactaca tagatcatca ttttgtctgt gaataaagag agttactcct ttctttccca 86160
attagttcct ttatttattt ttgtcttgcc ttattgcact ggctggaacc ttcagtatgc 86220
tgttgagtag atacagtgag agtagacatc cttgtttttt ttcctgatcc tagagggaaa 86280
gcattcatgt ttccttcatt aaatatgata ttagctgtgg acttttcata tatatatatt 86340
tttaatcagg ttaaggaagt ttctttttac tcctagtttg ctgagagatt ttgtcaggaa 86400
tggatgttag atttttgtca aattcttttt ccagatcctt gagatgtttt tgagatgtat 86460
ggtttgtttg ttgttttaat aatggtgagt tatatgaatt gatctcagat attaaacata 86520
gcttttattt ctgggagaaa tccagttggt taggatgttt tatctttttt atctatcatt 86580
ggattcaatt tgttaaatta ctaaaattta gctaatttgc taaaattcat ttaaaatttt 86640
tgtatctatg agagacattg atgtatagtt ttcttttctt atttttgtct gacttgcatc 86700
attgtaatgc tagcctcata ggatgagttg ggaagtattt cttcttcctg aattttctgg 86760
aagaatttat atagaattgg tattattttt tctgtaagta tttgatggaa tttaccaatg 86820
aagccacttg aacttggcaa tttctttgtg agaatatttt tgactgaata tccagcttct 86880
ttcaaagata tagttctatt caagttacgt atttcttgtc gagtgatctt tggtatttgt 86940
ttctttgaag aaatttatcc ctttcatcta aattatcaaa tttattggaa taaaattatt 87000
cataatattt cttttttatt attttaatat tggtagagtc tgtagtgtgt tacttctgtc 87060
ttccctgtct ccccctccct cccacttgtt tctgatactg gtaatttatg tcttcttttt 87120
ttcttcccaa ttagtccagc tagaggttta tcaatgttat tgatgatctc gatgaaccag 87180
ctagctctca gttaaatgat tttcttttct tttcttatct ttaaaaaaaa aaaaaaaaaa 87240
aagtcagggt cttgctctgt ggcccaggct ggagtgcagt ggcatcatcc tagctcaacc 87300
caaccttgaa ctcctgggct caagggatct tcccacatca gtctcctgag tagctgggac 87360
tacaggcatg cactaccacc accctgctaa ttgaattttt tttttttttt ttggaggtgg 87420
ggtctcactt tgttgaccag gctagtctca aactcctggc ctcaagccat cctcccacct 87480
tggcccccta aagcattgga attacaggtg tgagccatgg cgtctggcct ccgttacatg 87540
attttctgta ttgcttttct attattattt tttttgacgg ggagcggtgt tcgttctgat 87600
tgtggtttct tccttttact tatttttgct taatttgctt tttttgtttg tttcttaagg 87660
tggtccatgt tccttttaaa ctgtgaaatt ttttaaacat agactaaatt acagaggaga 87720
aacagctacc caaatcctat attggcatat ttactcttta tatgtcttca aatattataa 87780
atagaattaa agccctcatc acatttccct ttccagatct catcactacc ctgagtgttt 87840
cctttaactt gtttgtttag gtcatccata tgtgcatttt cccctacatt ttacataata 87900
tcgctttatg tattttcaca tttaagtaaa tggaatccta tatgcgttct ttattgtaca 87960
ttttattcaa catagtttta ttcaacatag ttttcaagat ttatgtaaat atagattcgt 88020
aatatacaga tttagttaat ttattttaac tgtagtattc taatgattaa atacaccttt 88080
ttattttatt tttttagaaa taatcataat gtagattgct tctcattttt ttataattat 88140
aaacagcaca aaaatgaaga attgttttgc atgtctcttt gacaacttag gttacagatt 88200
atttagcata tgtccctgga aatacagtta ctaaatttaa tgatacaaat gtctccaact 88260
ggagtaccga cttaaatttc caccaaaatt tctatatcaa taattgtatt tggtatcagc 88320
cattcctgac tgttagtagc ttgcttactt tatagtttca gttgttaagg ttacctcatg 88380
atccacattg gctcctagag ttcagctatc atgtccacac gaaggaaaag aaaagggaag 88440
aactaaaagg attttcctgg agtcacaaac cagtggtttt gtgttgatac ctctttggct 88500
gcctttctat actttaaaga ctgggaaatg tagattttag ccacatacat tgtacagagg 88560
aaagggggaa tggttattta gtatgccatc agcatttact gtcacagatc tccttttacc 88620
tggtgtgtac taacatttga taataaacgt ttaatttttg gcagtttgaa atggtatctc 88680
acttttaaaa ttgcatttcc ttgattggtg agatacagaa ttttttacat gtatttaggc 88740
tttttttaaa aaaaaattgc ctttgatata attctactga gtttggtctt tccctaatta 88800
gtttagcata actctttatt attcaggata ctgatctttt gtttctttac atccaaatag 88860
atgtttttgt ctcttatttt taaacttttg gtatgttgtc cttgtttata cacaagtgtt 88920
cattattatg gggttaaatt taacaggtct tatcctttgt gatttgttgt ttttatgtgt 88980
gttcttggga aaaatttttt tcctatataa aagtcatgga gaactcttag aaaaaaagtt 89040
ttaaactttt gctttttgca aaatccattt gggagttttt gtatatatat ttgtgaatga 89100
tttaatgtca gaatttaatg tttttctata tggaaggcca gttgtcccag cagcattcat 89160
tgaataatgc attcttttgc tatgatctgc tttgttaact tctgtcatat atcagatttc 89220
tgtctgtgca tgaacttttg catctgtttc tttggtgtat ttatctttta tttgtgattg 89280
cttcataaaa agtctttgtg tagtaggtca gtatctcttc tttaaaatta tcttagttat 89340
tcttggctct actttaatat aagctttagg gtcagcttgt tcaggtcctt gaaaattttg 89400
attagaattt aactgaattc ttagattaat ttgggagaat ttgacgtgct tctcatcttg 89460
aatcttcaca tttgtaatca tggtctgcta ctccatttgt tcaggttatt gttatgtcct 89520
ttagtaacat tttatatttg ttttcataaa ggttctgcct attttattag atacatttcc 89580
tggtgactta gtttatattt ttattgagaa tgatatcttt ttattttcga attagttatt 89640
ggtatatgtt attggttata tacggatctt taggaaccct tccttatgtt accttagtag 89700
ttgagttgtt catcattctc cagctttttt tcccccaata aacccacatt tattcacttc 89760
ttctgcattt cagacctgtg gtcatcctgt tttctgcttg agcatgacag tcatgctgct 89820
gtcactacct ttttcaggca gctcagagca tttcattttt taaatgcagc tcattgccat 89880
tgtgttgttt gtatgaccaa aaggaactgt cagagagata agaaggttac attaggttat 89940
gttccttaaa aatcacaaag acctctctat ctcattgctc ttttctgtcc ccccttctca 90000
tcttcagttc tcggtttact tgttaccttt attctcccac tcccatgtcc atctttctct 90060
tttatttgcc cacatttccc ttccttctcc cttccatttg gtaactatag tttttagcac 90120
ctgccaggca ctttagtttg tgctttgcat atgttaactc atttgccctt tatcacagtc 90180
cactgaggat ggtggggcag tctcatttca tagctgagga tgcgaggagg cccaagctta 90240
tataagtaga aagtaggaga gcttggataa tgtcaggctt ttcagactcc taatgtcatt 90300
tttttttccg ctttgctata ttattgaggt tgtttctttc tactgttttt ataagtggat 90360
gaagtaaatg tgctgtatgt ctctaataag attttttagt aaacctattt agatagtgtc 90420
tctaaaataa agctgtgtct gttttgggtg gagggtgtta ctcgatcttt catgatagcc 90480
attctcatag atcactctaa agaaaaagag atttacagag agaagaaaga tttaaatgca 90540
gaaataataa gtaaaattta ctacgtcaaa tatgctttac aaaaacatta tgtatagcca 90600
tgtatctgtg aatgttctag aaagtggtcc ttttgtaaga gtgcatggca aacgttgata 90660
gaagaaacac attagggaca gtggattcta ttcatgggta gtgtattgtt ctgggcaagt 90720
aattttactt ttaacaggca ttaatctcct atataatcca aggataggat tgattatata 90780
attattatat aatcgaagga taggagatta atgggtagaa aatctttgat gatacagctg 90840
tatttataaa taagtaacaa catacagaac tgtataattt tttaaaaatc attttgatag 90900
tattttcatt tttgtaaggt actttgtagt tcttgttcat ctgtgtatcc tgtactttta 90960
cagttataat catggtatct acttttattt tttatttttt catgactcat gcatctctct 91020
catgaactgt attcattttc aaaaaaattg attttagata atctctttaa tgttgttgta 91080
ttcccttttg tgagatagtt cctcggtttc tagttttgtt ttgttttttc tttttgtaat 91140
ttatggaaca tttaagttac attcccagtc ataggatgat tctataaaat ggtatcaaca 91200
catttatttc tgttttattg tcaaattgct ttcaaattgg tttaaaacaa tctataatgc 91260
aagaaatgtt tgaatgattc agtttaatta tagccagcat ccagtcattt aacaagtatt 91320
tattgagtct ttgttctggc agaggttaca ttctagtagg gaatatatga gacaaacata 91380
ataaataagt aaattacact ttatattaga ggatgatgaa ggctttacag aacagagcag 91440
gataagggag tgcctgatgg gatgacttgc gctttgcatc agttaaagta ggcctcactg 91500
agaaggtggc atttgtacgg ggtcttgagg catgggattt actttatgta tttttgtctt 91560
tttccttttt tttttttttt ttttggctaa tttaagaagt ttatgtagtc tcttaagatt 91620
actgtcatct attttcattg ttagtaagaa tggttttcta cacatttcct attttttttt 91680
ctattttggc aaaatttgaa attttaatga aagcacagaa gttttctgtg taagcctgtc 91740
cctgtccata caattaaaga gtggggaaaa ttggctttaa ctacattgtt tatgtttaaa 91800
cctgagtaga atattctgtt gaaggcttta acaagaaaac aaaaattatt actagtttga 91860
catttgaaat aagcaagaat aagattgctc ctttctattg tatttccatt ttaagtaaag 91920
gcaaggtgat atttaagatg tataagaata acagatattt gttattttat agggtgactg 91980
ttggatctgt atggaactca tgtctacctc gtttgataag ttttacaaat atgtatatag 92040
tgtattagat gatgttattc cagaagaaat tttaggcaaa atcactttag cagtaagtac 92100
ctggtcttta aattattcat tgtgtatata gttatataga gatgctgctg gagttttgaa 92160
tgcacatatt tgagtgtcac tcacagtacc ttcctgaaaa taattcatag ttaataacca 92220
gagacaaagt cacttctgtg gggtagttaa cacaataggt cataatggtc tcgataaata 92280
ctgccaatgt tctttccctt tgaatctcaa tgagtcataa cagactgttc tgtaaataaa 92340
gctaggaaaa gcaattttct gttcattttt tcctgttgct ttaactattt ttaaataggt 92400
tatattacca cagttatcct gaaattaatc agaatcacag cagtctcctt gaagccccat 92460
aattgaagcc cttggacaaa gtttgtttac tgtgatttaa gattttggtt actccataat 92520
tgaagccctt ggacaaagta tgtttactgt gatttaagat tttggttatt cagtctaaac 92580
tatttaaaat tttgactagc agtttcaggg gccagtgtta ctactaaatt tggttaactc 92640
acttttacca gagtaccaaa aaagaaaata gctacttttt tacatatgtg tttatagttt 92700
tgaaagtgaa ttgatcactt tgtttcttgc tctgaatctt aatttttttt cctaaaggaa 92760
aaagataatt tactttttat agagcaaaat tcataagatt cttagaaact cctgagaatc 92820
tgagctaatg gcatgttcta ggttagttga tatataaact aaatcataca ggaaattgta 92880
aaatagatac tttggttgca tgtaatttcc tagctcttcc ttacctgcat actccccctc 92940
caatgtagtt caccaagata tatactcttt caaataattt cataaaaaga ttttatgaaa 93000
tcattttatt tttaaatttt ataaaaataa ttgtataaaa agaagctaac ttagactaga 93060
aacttattat ttagcggggt atatgaaatt ttacaatgat tagtttagcc atctctctct 93120
aatatattaa acccgtgtta tcttgaaact tactatttgt aataattata ataatagaaa 93180
aatgataata gctaatggtt attaaatgct tatttgcatc aaactatttg tgacattaaa 93240
tcttcatagt aactctctgt ggtaaatagt gttacctcat ttttatgaat gataaatctg 93300
aagcatagac agattaaata attaatatgc tttgaagtgt gtaagtggta aataatctaa 93360
atccaggcag cctgatccca gaaccctgct cttaaccgct gtataacagg gtgaccatga 93420
aattagaaaa cagaaaatta ttttatcata tattgcaata taaagaatat atactgtaaa 93480
aaatgattta ttccatattt gcctaagtca agacttggtg atcactttat atatattaag 93540
cacacatgta aaatactttg tatttagtct cttcttgcta attaataaac cagcaaacaa 93600
gcatagctat tcacaacaaa tttatgtgtt ctacatttct tgtacctagc agcttgacgt 93660
cagcaaagac gtcaccttac agcaaatagt tggcctgttg tttagttctc ttttagtttg 93720
aggttgtgtc tcttttcctt cccttcctga agaaatgtgt aattttctga tcatgatcag 93780
tgaccaggca acaggataaa ttcccacagt ggtgaacaga gtttacacta gctcttcaaa 93840
catcaccttg aaggcttagc atccaatgag ggtggatgat gatgaggaac tgagagttta 93900
gaaaactttt ttatttacta ctggacttag aaattgaaat cgattttgct gcaagttatt 93960
actcttagtt gaaatggaac caactcagtg atcattgttg tcctgttttt atttttgaac 94020
attttagagg ccaggcacaa tggttcatgc ctgtaatccc agcagtttga gaggccgagg 94080
cagaaggatc gcttgagccc aggaatttga gatcagcttg ggcaacatag tgagaaccct 94140
gtccatacta aagatgtaaa aagttagcca ggcatgcatc tgtagtccca gctacttggc 94200
aggctgtggt gggagcgaga cccagtctca aaataaaaag ggaaaaaaaa aaaggaaatt 94260
ttaggttgga gataggaaaa aagataaaat tttaaatgaa ttattaaaca aattataagt 94320
ctaagttact gggttttttg tttgtttgag ctatcaggga acagcatata aaggcaacta 94380
agcttttaga tctaaaatta ttcagtatct ttggttaaca agaaatgaca aaatattgaa 94440
atattaagct taaaatgtat gcagaggact acacgggata ttacttgtga taaactgttg 94500
tgctgtttga ataaaaagaa acaagttgtt tatcccatct ctcctttttc tccctagact 94560
gtgaaagcac taaaccactt aaaagaaaac ttgaaaatta ttcacagagg tgggtatgga 94620
ttggtatttt ttgtaataga aattaacttt tttctcctaa ttggtgaaac ggttattgaa 94680
aattacagtg tcactgtata aactttccta aaatatttgt atttttagca aaaaatgctt 94740
tatgtacttt aaaactctat tactgctatt tttttctttg ggattcaata aatttcagtc 94800
tatcttagta tgttggactt agaaactgaa atagattttg ctgcacattg ttattagttg 94860
aaaaataatt attcatttgc ctgatagata atgtttttct gcatacaaat aaggcatcga 94920
ggtggtcctg tggacattca aagaagaatc tgagggatag taccctcaag cattttaaag 94980
gcatgctatc cctgtctgtt gtttcttctt cacattagag gatgtttcta aattgagaga 95040
aatcttttaa ttagtattat aagttgaaat ttctctaaag catgttgtat ttgtgtaaac 95100
agtgatcttg cctttattag atacatattc aaatgaagca tttgatgtag ttgaaggcca 95160
gacctagaaa agtagtaacc ctgtgggaat cctgaattta atctggcaaa tagatgaagt 95220
gcttgcttta cttattactg tgctagactc agggtaatga ggtgctggct ttgaggaaac 95280
acaccgaatc actacccctc agcaaatttg taacggaaaa acctgacagt aagtggcagt 95340
gtgtgattta gcctgacagt aaataggaag gaaagtaaag ggtcaaaatg aagagaagtg 95400
aaaaatttct aattctggga gacaatttct agtggttaaa gaaattagta attgggccat 95460
ttatttaagt tcttttgttt gtggttgaca ctaggccact gaaattagtg aaccttgaac 95520
atcagtaaat tttatttaat tttgtttggc ttaatgcttg ttagaaataa tatctttttt 95580
tcttttggcc taaaattatg tagagttagg tccctaaaca aaattctttg tttctcttgt 95640
atttcttctt gttcttgtct tgattttttt ttttttccct tctttgttag ctgtgttcta 95700
taattatgag agtagcacct ttgaggcatt tgatagttac cttagggata tttactgatc 95760
acagtaaagc accaaggtac tgcctgggga gtagttgaat aaaataaaaa aacttcagaa 95820
gtaactttta ttgttctctt actaaatgaa gtgatgagtt tatagccatc ttttatcagt 95880
taggatcagt tagctttttt gttggagtca gtgcttttga ttacaagtaa tagaaaatcc 95940
tgataactct ctttaaactt cagggaaatt cattatctgt cataattagt ccaaagatgg 96000
ggtggctcaa agcacaatat gctcctcttc cttctgtcct ccttcatgtg ttaactctgt 96060
cctcagggta gtaacaacta gagcagttcc cactatcatg tctatatgtg gctgcctcgt 96120
gaagaagagg tgctctcgtg ctgtgcagct ctgtagggag tatggaaact tttcccacgt 96180
ctctaatacc ttttcttggc tcattcacca gaagtgcctc atgcccttaa accagctact 96240
atcaagaagc atgagactac ccttataaaa cttataccag ccaacagcca ggttttcgag 96300
gtgtggatgt tgatgagaag agatacttca ataaaacaca ggttctgtta gaaagtatgg 96360
atggggctgg gtgtggtggc tgacacctgt aatcccagca ctttggagac caaggcagct 96420
ggatcacttg aggtcagaag ttcgagacca gcctagccaa catggtgaaa ccccatctct 96480
actaaaaata caaaaattag ccaggtgtgg tggcgcatgc ctgtaatccc agctacttgg 96540
gaggctgaag cagaagaatc gattgaactt gggaggcgga ggttgcagtg agtggggatt 96600
gcaccactgc attccagcct gggtaaaaaa gagcgagact cttgtctcaa aaaaaaaaaa 96660
aaaaaaaagc atggatggtt aggaatggat gtttgatagg cccacagctg tttcggtcat 96720
ggtaagagat ctttactgaa tttttttgtg gatcaccttc tgagttacat ttagatgttt 96780
tctgcatcct atattttaaa accttatttt ttattcattg agccaggata gtgacaagga 96840
catggataaa aggactgagc tatggataga gaattagttg gcacatactg gtagtgactt 96900
gattgtcaat gagaaaggga tttgacattc cttatatttt gactgttatg taatgaatct 96960
ggactaagta aatgaatttg taagcctctt gaaaacaatt taatgcctaa atttcttgtg 97020
aaaatttttt ttgatattca gtttttaagc actggcattc agaaaattgt tttcctttct 97080
cattttcaat agaagaaaac cattgttttt tctgtgtttt ataaatatga agatgttaag 97140
agaaaaatca atccccatct atatcttaca gattaatgtt tgtgaaatga cttttgctgt 97200
tacatttaca caattatagt tattaaagct acatgtttaa aacatgaata attattgtat 97260
gtgataaatg aagatgtttt acttcttata tatctgaatt taaggacttg accacttatg 97320
ttgtctaagg tttttcaata tttttgctta aagtgaagcc ttatgtaact taggaagaag 97380
ctaattgtat actgaatgat atctatgtct tgcagatatc aaaccttcca atattcttct 97440
ggacagaagt ggaaatatta agctctgtga cttcggcatc agtggacagc ttgtggactc 97500
tattgccaag acaagagatg ctggctgtag gccatacatg gcagtaagtg ttaagtccag 97560
gccttcttgc ttgatagtca ttgcacagag agcctgtgct cttttgtgct ggccattagt 97620
catacggttt taccatgaaa ctgctagaat atttccctta ccctaaggcc caagctcagg 97680
tcctagcctc tccatgaaac tttgctaaat tatcccagtc agctcctgtt ttcattgtct 97740
tgctttattt ctcttacttg gtatttagca gttgtggtct tctctgatta ttgttttttc 97800
attatattga actcaactca ttaaacagat ggtaacttct cagaaagttc ccaccgtccc 97860
ttagtgagac aaatgggaag ccttgagttc attagcagaa ttcactatgt attacagagt 97920
ctgaagctgc atattttgaa tattgttagt cctttttttt aggggtagat gaagcacacc 97980
aacaaatgca aaggtagagg ccttcagtat tttgcaacct ggagcctctt ttcctgcaaa 98040
gagacagatg tacactatcc atccatagat atcaaactca tcttacccca gtatatttgc 98100
atacagtgtt cctacagcct ggattttgat ctgtatttga atgaaaatgt agtgtctgta 98160
tttcagacat ttccctaggt gttaatgtct ttcttcaatg ttgccatggt tctttgggga 98220
ccagcacact actaaatgtg acacataagg ttttgtggtt gtttcttgag gcctccctgc 98280
cagcagcatt tctttccatc tttgtagact gttttaaact aaagataagc ttagaattga 98340
ataaaattgt tctttcttgg tttcctcctt gatatatatg ttttcaaacc tagtgctata 98400
aataataaaa aagtaagagt cacaggctag atattatagg tgttctagat tatttatgaa 98460
tggataggct tagtgctact acaaattcaa cttactgcat ttttcaatcc tcttttggtt 98520
ttgttatatc ttcccatatc actttttctt cagatgaaca tgtaaaagcg gtgtgtgtgt 98580
gtgtgtgtgt gtgtgtgtgt agacacctaa cctgtgtggt aagacctttt aaacttttgg 98640
ttttgtggat gttgactggc tgggcagatt tcttgactca gtttggaaga tcatttgttt 98700
atcgtgataa ctagggataa atggcacaat agtttcaaag gcaagaaata aaaaaaatta 98760
gacatggagt atttgggaaa tgtgatttac atatttatta aggatacccc gagaatgaac 98820
tgaaattgtt atttacagtt ttagggcttg tctcgatact aacagtgact aaatgttttt 98880
gttgtgtgac actgactaag aattatattt gattgaagca ggctttgaaa atgcaattgc 98940
agcccagata aagtagaata ttttgaattc agctttctaa gaaagactca gactttcttt 99000
aaaacagact ttcgtcattc ttgtgcagag atatgctttg caggcccagg agatgtaaga 99060
cttctgtttt cttgctgacc ttcatctgtg gaacacaaag gctgataaac tcttggcctc 99120
taatctttac tggaccagat gaaattcttc tgtccattct catctttcaa agcctgttat 99180
agatagacaa gaactcaatc aatgttaatt ttaaaaggct tcaagtggtt tgacttttct 99240
tcaaatattg acaaaaccta ttggaggtat atcattttat ttgagattta tagttgtctt 99300
tagtctacag gacttaggat tactcattag attgtgcaac ataaaaaagt aaataaaatg 99360
tagagtttac acataaattt tcctgtaaac cgatttcttg taaacatttt cccaactcca 99420
taccctcatg taggtacaca gtcttatgtt gcttaaccgt gggaatatgt tctgagaagt 99480
gtgttgttag gcaattttgt tgtgcaaaat cataagtgta cttacacaaa cctagatggt 99540
atagcctact acacacatag gctatatggt acagcctgtt gcttctagac tacaagccta 99600
tacagcatgt tactgtacta aatactgtag gtaattatat cacaacagca actatttgtg 99660
tgtctaaata tagaaaaggt acggtcaaaa tatggtataa aggaggtaga ggtgacgggc 99720
cggagaaaga tggaagacta ccaggctgcg gaggagactg cttttgttgt tgatgaagtg 99780
agcaaattgt aaaagaggct atagaaagca caattggtgg ttaacgctta ttaacacagc 99840
aaagtgaacc agtggaacac aaatgtagta gaacaaactt caagccaact caccaagctg 99900
ggaaaaccac ttaaatacat tgtgacctgt gtaattatgc aaaagaatgg agctggatta 99960
cacatggcaa gttcctgctt ctgggacagc tctgctgaca ggagctgcac tgtgcgatgg 100020
gagaataaaa ccatgtactg catcgtcggc acctttggac tgtgtattgg acctcctagt 100080
ccagcctgtg accttcctcc ggtagttcat cttctaacac cagctatgaa ttgagtgaac 100140
tcttttctcg ttctttttaa gtctgttttg tggcactcta aaaatgcaga gaaaaaaacc 100200
aaatgaccgc actgttacat gaactgtgca ctgaagtcag atgagtatcc ctgtaggtcg 100260
cctgcagcct gcattgccac ttgtaactct gaatatttct tttcaaaggt gctaaaatct 100320
gaaatctgct ggtgtgaaac ttgctatact gtctgaaatg attcaaatac actaattttc 100380
catactttat acttttgtta gaataaatta ttcaaatcta aaaaaatatg gtataaaaaa 100440
taaagaatgg ttcactggta taaggcacta atcatgaatg gagcttacag gactagaagt 100500
tgttctggat gagtcagtga gtgagtggta agtgaatttg caggcctagg atgctactgt 100560
agactttata aacactgtac acttaggcta catgacattt ataaaaattt ttttcttcag 100620
taataaatta acctgagtgt actgtaactt ttttacttta tacacttttt aattaaaaaa 100680
aatttttttt acttttttgt attaacactt agcttaaaac acaaacacac tgtacagccg 100740
tacaaaaata ttttctttct ttgtatcttt attccgtaag gctattctgt ttacttgttt 100800
attcttttta aacttttttg ttaaaaacta agacatcatt ctaggcctat acatgggcgc 100860
gatcaatcac tgtcttctac atccacatct tgccccactg gaaggtcctc aggggcagta 100920
acacgcaggg agctgtcatc tcctatgata tcaatgcctt ctttgtaata cctcctgaaa 100980
gacctgccag aagctgttga taactttttt ttaaataagt agaaggacat caagtatagt 101040
gtactgtaca taattgtatg tgctatactt ttaaatgact ggcagtgcaa taggtttgtt 101100
taaaacagca tcaccacgag cgcgagtaat gtgtcactct acgttatgag ggctatggtg 101160
tcattaggag ataggaattt ttcagctcca ttataacctt atgggacaac ctttgtatat 101220
gtggtctgtc gttcaccaaa atgttgtttt gcagcacgag acaatttctg tatgtgggta 101280
tggatgtgcc aaaccacctg aaagttagtt gcagatatca tgcattttat tctaaacact 101340
tcagtgcata tctcccaaga aaaagaccat tcttctacat aaccacgata tcattaccac 101400
acctaaaaaa aacaaacaag aatgtcatct ttgagcatcc ccattccaaa aatgcaaagc 101460
ccgaaatgct cccaaatatg aaacgttacc aacactagtg tgacccaagt ggaaaattca 101520
cctgacctta tgcgatgggt cacattcaaa atgcaggtgc accacatctt gttgattcag 101580
tgttcccaag gtaaaaaaaa aaagaccctt gtggccccct ttagctgcaa tatatctttt 101640
ccacacatgc ccagattttc cccacataag catgcctaca aagggtaata aaatggcatg 101700
tatgcaggca agatgtgcta atgacaggtt ccacactata cctcacatgg ggccaagacc 101760
tacctgcatt actcactgta tttttttttg ttttttttgc tcattttttg ctcagtagct 101820
taaagttaat gttgaaaatg tcaaagaggc ctgcagatac ccctagagag acagcagttt 101880
gttaaagggg ataaagggga agtgtttatg tttatagcac agaaagtcaa gctgttagag 101940
aaactggaca atggtgtaaa tgtgaaatgt cttacagaaa agtgtggtgt tcgtatgagc 102000
accatatatg acctgaagaa acagaaggag aaactgctga agttctgtgc tgaaagtgat 102060
gaacaaaagt tactgaaaaa tagaaaaaca ccacataata gctaaaaatg aagatcttgg 102120
taatgtatta aaagagtgga tctgtcagac tcacagtgaa cacatgccat ttgatggtat 102180
gctcatcatg aaatgaacat ctatcatgaa gaactgaaaa ttgaagggaa ctgtgaagat 102240
tcaacagact ggttatagaa atttaagaaa aaacatagca ttaacttttt aaagatttat 102300
ggtgataaag catctgctga tcatgaagca gtggagaaat tcattgatga attcgccagg 102360
gttattgatg atgaaaattc aacatcagaa caggtataat gctgatgaaa catcactgtt 102420
ttggcatgat taccccagaa agacactaca gctgatgaga cagcccctgc aagatttaag 102480
gatgccaaga gcagaaaaac tgtgacggga tgtattaatg cagtaggccc gtataggtat 102540
aaatctatag gaggcaaaag cttgcatcct tcctgttttc aagaagtgaa tgtcttacca 102600
gtccattatt atactaatca aaaggcctgg atcactcggg ataccttttc tgattggttt 102660
cataaacatt ttgtaccagt gccttatgct tattgcaggg aagctggact gaaagaagag 102720
tgaaagattt tgttatccat tgataactgt tctgcttatg ctgcaaccga aattctcata 102780
aaaaataatg tttatgccat gtactttcac ccaaatgcga cttcattaat tcagccatgt 102840
gaccaggata tccttagatc agtgaagggt aaatataaaa acactgtctt gaacatcatg 102900
ctagcagcag tgaacagagg tgtgggtgtg gaaggttttc agaaggcgtt tagcatgaag 102960
gatgtcatac atgctgttgc cagcacttgg ccaacagtga ctaagacaca gtcatgcctg 103020
cttggcataa cctctggcct gtgactattc agtgatgatg atgatgatga acaaggtagt 103080
gacttggatg gattccatat gttaaagtga gaaaaaaatg atatctgacc tccttttata 103140
tgcaaaaaat acatctttag agtctgtcag taaacggaaa gaaggggata ttaaagaagt 103200
ttttattatc aaattaatga agcttcagtt tttcatttat tgactaatga tgaaatagct 103260
gaaatggttc tgaatcaagg taaatgtgat atttagtgat aatgaggatg atgttaacaa 103320
cgaggaagaa atgcccatag acaaagtgca cattctgcat atcaaaagaa actatcaaca 103380
gagtaaacag ataatctgca gaatgggaga aaatatttac aaataactat gtgtctcaca 103440
aagttctaat attcagcatc tataaggaac ttaaatttat aagaaagaaa acaacctcat 103500
taaaaagtgg gtaaggacgt gaacagacac ttttcaaaag aagacatgca tgcatccaac 103560
aagcatatga aaaacacaat gtcactgatt attggagaaa tgcaaatcaa aaccacaatg 103620
agatacatct cacaccagtc agaatggctg ttaaaaaatg tcaaaacaac agatgctggt 103680
gaggttatgg agaaaaggga atacttatat actgttggtg gaaatgtaaa ttaattcaac 103740
cattgtggaa agcagtgtgg tgattcctca aaaagctaaa aacagaattg tcattcaacc 103800
cagcagttcc attactggaa atgggtatat accaaaagga atagaagtca ttctgtcata 103860
aagacacata cacacatatg ttcattgcag cactattcac aatagcaaag acatgtaatc 103920
aacctaaatg tccatcagtg gaagactgga taaagaaaat gtggtacata tacactgtgg 103980
aatactctac agccataaaa aagaatgaga gcatgtcctt tgtgggaaca tggatggagc 104040
tgtaggccat ccattaatat ctaaggatac ttacttagca aactaatgca ggaacagaaa 104100
atcaaatacc acatgttctc ttaagtggga gctaaatgat gagaacacat ggacacaaag 104160
agcaacaaaa cagacactgg ggcctacttg agtgtgggag gtgggagagg atcagaaaaa 104220
ataactattg ggtactaggc ttagtaactg ggtgaccaaa tggtctgtac aacagacctc 104280
tgtggcatga gtttacctat ataacaaacc tgcatgtgta atcctgggcc taaagtaaaa 104340
gtttaaaaaa aataaaaatt aggccgggcg cggtggcaca tgcctgtaat cccagcactt 104400
tgggaggcca aggtaggcgg atcacttgaa gccaggaatt caagaccagc ctggccaaca 104460
tgtgaaaccc catcactact aaaaatacaa aaattagcca ggcacagtgg cacatgcctg 104520
taatcccagc tagtcaggag gctgaggcat gagaattgct tgaacccagg aggcagaagt 104580
tgcagtgagc tgaggttgtg ccactacact tcagcctggg caacagagca agattctgtc 104640
tcaaaaaaca tatatataaa taaaaaggaa aaaaactaaa aaaagtttta aagaaaatgg 104700
aaacaagctc cctcattccc ccccccataa aaaagaaaaa atgctcttga tgaaaatgtg 104760
taatggactc attaaaggat tagagcagta tgcattcata acacaagaag aaatcatgtc 104820
agtttataaa actgaagaga gactcctaag acaaaaacca ttgttaatga ggcagttgac 104880
tagggaggaa acattttaca aagccatcta gcagaatgcc tcctcattac tagaggaccc 104940
acttctggcc cctcaaatgc ttctgatgtt tcttctcacc taaaaaaata aaatacagtg 105000
tacaatagcc ttttaatcaa aacacagcat cgtagttgga ggttgaaagc ttgtagctgt 105060
ttgttgtagc tgctgtttaa cagttgatgc aggtattctg gcgatgctac tgtgctgctt 105120
agttccccag aactcattgt ttttcactgt attgatacgt catatttttt actgttaagt 105180
atttgtgtga acaagtgtaa gacaatgatt gcctattaat agcatgtaaa ttccgagtcc 105240
ggaatgatgg tgatgcccag caaccacaga ttgtctacct gggtggctga gatagtgaca 105300
cttttgcttt ttggtgcttc agtgtacaca aactttgttt catgcacaaa tttatttaaa 105360
atataatata aaattacctt caggctatgt atatagttgt atatgaaaca taaataaatt 105420
tcacgtttag acttgggtcc catccccaag atatattatt atgtatatgc aaatattcca 105480
aaatttgaaa aaatccaaaa tcgaaacact caggttccaa gctttttgga tgaggaatac 105540
tcaatctgta ttatctaata catagttcat actcagattt cccatatgtc aaaaaaacta 105600
tcttttagct gtcaatccag ggtcacatta agattccata ccagctactc aggaggctga 105660
ggcaggagaa tggcgggaac ccgggaggcg gagcttgcag tgagccgaga tcgcgccact 105720
gcactccagc ctgggtgaca gagcgagact ccgtctcaaa aaaaaaaaaa aaaaaaagat 105780
tccacattga ttttaattgt tacattattt taatatatac agggcttgat cattcttttt 105840
gttttctgtg acattggcgg ttttggaagt gttttcagaa ggtctcgcat tcttataata 105900
tctgattgtt ccctcatgat tagattcaga ctacaactat ttttagacat gcatacttca 105960
tgtatgagga gtgtttttta ttgcataaca ttgcaaagca cataatggtt actatttgta 106020
atgtttacag acatgccttt tttttaagca gttaaaacag ttgcagaata gaaagtggta 106080
tgtttcttta ttcatttagg tcttcttgcc atctctcagc aatgttttgt agttttcagt 106140
gtgcagcttt tgaagacctt ttaaatttat ttctaaggag ttcatggttt ttcgatactg 106200
tgaaaggaaa ataaaaactt gggaccccaa tttactatgc caaaacaaaa aattcagctg 106260
aaagctgagt gatgtaaata aaaaactgcc tttccttttg ttcttaagca gatagctaca 106320
gataaagttt taaatatctc cacaggtagc tattccgttc accttatctt atttaagtgc 106380
taacttactg aggatgagag gaatacataa tcaactattc cgtacttgct ccttttctct 106440
tgcaacatac ggattcagta atgtgaccac accctccctc gtccccctgc tgcctgcttt 106500
tcctctttaa ttattgaagc cctcaaaatc atatttggag aaaggcacaa acttcccttt 106560
caggcatgtc cttaaccgtg gcaagataaa cttctaaatt gattgagacc tgtctcggat 106620
ttctttttgt cttagaatac tgttattggg agtggaatta aaaatatttt ccaatatttt 106680
gctattatta tatagaaata caactgcttt gcatgtgtta acattggatc ttgtgacctt 106740
gctagtttag ttttactgtt agtttcagta ggaattttct gtgtctgtga ataaaggtaa 106800
tgcttgtttt cccccttgcc tttctatact ggctgggtcc tccagtagaa tcctgaatag 106860
taataataat agtaggcata tttgccttat gcccaatatt aattaaaaag aaagtgttct 106920
atatttcacc agtaagtata atgttaactc ttggttattt tagatgccct ttatggaaat 106980
gaagatgttt tcttctctta gtgtgttgtt atttctgttg ttattagtgg gttttacatt 107040
ttgtcagatg ctaattctac atttattgag atgatcacat tattttcttc ctttctataa 107100
ataatggtgc attgcattga ttttcaagta ttaagttagt attgtattct tgagataaac 107160
tctacttggt catgatacat tacctctttg tatgttgctg gattaggttt gctcatattt 107220
tgttattttt gtgtctttct gtgcaagggc tattaattgt cttgtaatga ctttgtcagg 107280
ttttcaaaaa tcgttatgct ggcctcatga aatgagttgg gaagcgtacc atctctcact 107340
tttttgaaaa aaaaatttgt gtaaggccag tgttatttct cacgtatttg aaaagagttc 107400
accagtgagc ccatctgggt gtggactttt ctttctgggc aggtttttaa taacattcat 107460
taagtaacat agtttaaagg ttattcacac tttgatattc tttttggtag gttttcattt 107520
tcagaaaata tttctgtttc atctatttct gtaagaacag tagtaatggc ccctctttca 107580
ttctgatttt agtaatttgt atcttttctt tttctgtggg tcagtctagc caaaggtgtg 107640
tccattttat tgatcttttc aaagtactgt tggttttctt gacttttctc tattgttttt 107700
ctattcctgt tttacttgtc ttcacgttac tttttcttac gttcttcctc ctgcttgctt 107760
tgtatttcat ttgttctttt ttttctaatt ctttaagcta taaagtaggt ttgatttgag 107820
atgtcttctc ttctaatgta tgcattttac actatacatt ttcttctgag cactacttct 107880
atatcccaca aattttggga agttgtaatt tcattttcat ttagttcaat tttttaacta 107940
tttcttgaga cttttttgat ccatttgtca tttagaggtg tgttgttaaa tcttcagata 108000
tttgaggact ttgcagatat cttcctgtta ctgatttcta atttatttat tttgtgatct 108060
gagaacatgc tttgcatgct ttccatcttt taaaacaagg tgtgttttat gccccagaat 108120
gtggtcagga ttaatcaatg ttccatgcta gtttggggaa aatgttgatc ttgatgatgt 108180
tggatggagt attttttctc ttggttgaat atctgggatt ttaatgtgta ccttatcagg 108240
caaatactta tatttacaac aaaaaaaaac aaagtaaata gcttacagtg aattttatgc 108300
agcacagtac tcatgctcaa agcaatatac agatgtcttt agttgatgct cacaggcaga 108360
gaatgtaata cagtcaacta ttatgcttct ctgggcattt ctttcaacag cagttactct 108420
cagacttagc gaaggatcca ttgtcaactc tgtgccaaca ggaccctctc tctctcttcc 108480
cttttcctga cacatcattt agatggtccc taatttcaag gaaatgtaaa gatgttcttt 108540
cacagaaatt actaaaaatg atttctgcgg tacataggat aatatattac tgtcttggca 108600
gtgctttaat ttggctacaa atgactaaca gacaaatatc tttacacata tgtgtagtga 108660
taaatttagc gttattgtga agtatgggtg gaataattgt gataaattta gctcttgttt 108720
tgcttttgtg tctcaaatat attgtggtat ggcctcatcc accgagcaaa gtcttttaaa 108780
aatcgaagac agtctttttt gtttgtttgt cactcgttgc cccaaatttg acctaattct 108840
ttttttaaaa cctttttatt ttttaatttt ttttttgaga tggagcctcg ctctgttgtc 108900
caggctggag tgcagtggca tgatctcggc tcactgcaag ctctgcctcc cgggttcacg 108960
ccattctcct gcctcagcct cctgagtagc tgggactaca ggcacctgcc accaggccca 109020
gctacttttt tgtattttta gtagagatgg ggtttcaccg tgttagccag gatggtctcg 109080
atctgctgac ctcctgatcc acccgcttcg gcctcccaaa gtgctgggat tacgggcgtg 109140
cgccactgca cctggcgacc ttgtaattct ttatgttttc cagttttctt cctttgtctc 109200
cctcttccct cagcttcagc tttgtaaatg cttttgagtc tttgagggga atagttaaat 109260
gaattgctta gtgttctctt tatggaagta gccattaagt tttttgttgt ttgtttttat 109320
gataatgatg acttcctatt acttccattc tgacgctaga catggattcc tctaggaata 109380
tactggcatt ttggctgtct acccagctgt tgcttccatt tgcctattcc ttgagtgtaa 109440
ggcaattaat aacttacact tgtctttatg ttccagcctg aaagaataga cccaagcgca 109500
tcacgacaag gatatgatgt ccgctctgat gtctggagtt tggggatcac attggtatgt 109560
ttatgctgat tcaaccttgc cacagtagcg taacaataag aaatttagaa gtgaaagaaa 109620
acttaatcag acttccccgt tcgttaagaa ctataatcac agacactatg gttttaagtt 109680
gctgaaaaaa aaaaagtatg tatttattta ctttaaaaat caaatcagac ttgattattt 109740
cccttgaagt tatgtgaagt gtctagagcc ctttaatgtt ttaactggat ctcttggcca 109800
cagataatag gagtcaacta ttatctgcaa ctgcactaag aatgggaaca ggacaagcca 109860
gcttacctgc agtcaattca ttgatgaagg cacataggct tctcccatct caggcaaggt 109920
gtagtatgtc cagtaatact gtatatagtg tgtatattaa gtatacgtat ttttatatgt 109980
ggaaaatagt ttctacttgc aatattctat tcactgaata gtaaaatcac aagtgaatga 110040
gctgaaagta attcagtttt tgagggacaa tatattagtc cattctcaca ctactgtaaa 110100
gaactacatg agactgggta atttatgaag agaggtttaa ttgcctcaca gctccacagg 110160
tcgtacagga gcaggggaga gagagagtga aggggaaggt gccagacact tttaaacaac 110220
caggtctcat gagaactcta tcatgagaca gcactagggg gatggtgcat tagaaaccac 110280
cctcatgatc caatcacctc ccaccaggcc gctccttcaa cacataggga ttataattcg 110340
aaatgaaatt tgggtgggga cacagagcca aaccatatca gacaagaact acctaggtga 110400
taattctaaa tgaaagttct accttagaac aacactgaga aagaataata agaaagctac 110460
ttaatttgca acaagcaagc gcaattatat aaactcttct ttcttaccta tggactgtat 110520
tgaaattttg gtttcattta aaatatctgt attagttcag gctgctccaa ccaaatgctg 110580
acctctgggc tataatctta tcaagaacag aaatttctca cagtttcgga ggctgggaag 110640
tccaagatca aggcactgac agatttggtg gctagtgagg gcttgcttcc tggttcataa 110700
acagccatct tcttgttgta gtctcacatg gcagaagagg caagagagct gtctggggtc 110760
tttcttacaa gggcactaat tagattaatg agggttccac cctcgtgacc ccatcacttc 110820
ccaaagatcc accaccaaat accatcacat tagggattag gcttcaacat atggatttgc 110880
tggggggtgg ggacacacaa acattcagtc tctagcagta tctttgctca tttccttttt 110940
accaaatttt gttttgaagt cttcggttta ttttcttgtg cttgctgttc taccaggact 111000
tgctgggttt ttctgatttg ggatagcttc tttagctgct tctacattga aggcgaattt 111060
tctatcccta gatgaggctg tcctgtaggt aggcaggcca atcctcttct ttcattttct 111120
cccattttca gtttttgcta cctaagactc tatagcccag aaatacacag gttcagagca 111180
atgggctttt tttgtagctt attaaataat cttcatttgt tcattggtat tacatgtttc 111240
taggatcttc tctgtgatca gaagcacata accttgttag ttattcttga tgaatcatat 111300
tgctaggcct agagaattct tcgtatagag agttgaaggc caacagctca cctctgcaga 111360
ggactttgat ttactttact ttgtgaccaa atataggaaa taccttctgg aatcttttct 111420
cattgtgaag ccaaccagct aaagaagaga ttcttcttta gacaggagag aacatggatc 111480
tcgggcatct tttaggtttg gcaactggtc ccaaagactg cagcaagacc tagagcttcc 111540
agctgaggca actatttgca tacacaggat atttacaatt cagaaatact tatctatgac 111600
taaacaatta cgttttaaaa gcaagtatgt acttctttac agaaagaaaa ttttgtgaaa 111660
ggttttaaca gaaaattttt tagcaagttt cttttagtac ttttagctaa accttgttgt 111720
ttaaaaggta ttctgtactt acagttggtt cataatttat ttttcatagg gacagtctta 111780
taaaaattgt gaaatgtatg aaattaattt ctaagatcct aagtccttta ttttatgaca 111840
tacagccaac ttttccttct attattaaaa cacaagaagg aatctaatga agttattcct 111900
aattctgtga ataaccagga aggtttatgt cttgaaaagc atttataatt ttaacagaaa 111960
gaaacttcag ctaacggaat acatttttct gtgtgtgtat gcatgcatgc ctgcttactt 112020
ttgtgcacac atgtgtgtaa ttagaaacaa cagtgagctg acagaggcat cctttaggga 112080
ggaaacggaa tcagtgttct gagagttctc tctctcttcc tgtatgccat cttcctctgt 112140
aatatgtttg gagcctcatc ctcatgtatc agtcacctgt cagtgcatgt aaaatgggat 112200
tcattatgcc atggtgcaga tttaaatatg tttcttggaa aaagcaaaat ttgtaggttt 112260
tcttttcttt tgttttttga gatggagtct ctctctgtcc cccaggctgg agtgcagtgg 112320
cgcaatctcg gctcactgca aactccgcct cctgggttca tgccattccc ctgcctcagc 112380
ctcctgaata gctgggacta caggcgcctg ccaccacgcc cggctaattt tttgtatttt 112440
tagtagagat ggggtttcac cgtgttagac aggatggtgt ccatctcctg acctcctgat 112500
ccacccgcct cggcatccca aagtggtggg attacaggcg tgagccactg tgcccggcct 112560
aattggtagg ttttcattat ttttcagaac agaaagggag atagatgaga atacgattca 112620
ctggttatta gagaatattt tttttttgga cccttgatag gattgggaca tacgtaagac 112680
tcttcagatc tcttctggtg tggcttagag gtactgtcct gagcccttta ttggggcttc 112740
aggatgcagg gtttgaccct gacttgattt cttcactact tgtaaaatct ggttgtggtt 112800
gaaattgtag tatctgcaga atagctgtag agcaggattt gcacattgtt tcctccaagc 112860
tcagattagg cttttgtttg ttggatgttc ttttgcctta aaaaggagtc taaccacgat 112920
tatggaccaa ggccttcctc taagatggct acaaattgtg cgtattctat agtaaaatag 112980
ttctaaaacc agtcttccag actttcttat aaagaagtca gaaccacagg ctgccctgga 113040
gcatgcattg tagggacatt gtctaggctt aagttttgtg ttcccatgta ttccaagtcc 113100
ttgaatttgg ttgattcaga attctctata ttattttgat ttctaaatat aacttctact 113160
tagcctttat gattctgaag attcctcccc aagctaacct gtgtttaatt caaggcttta 113220
ctagagtttt gcttgtagtt tagatttttt tgtggccctt ccagtgggga gtagtaaatg 113280
atgcctggtg tattttgctc tttcctcttt gttctcttta gtatgagttg gccacaggcc 113340
gatttcctta tccaaagtgg aatagtgtat ttgatcaact aacacaagtc gtgaaaggag 113400
atcctccgca gctgagtaat tctgaggaaa gggaattctc cccgagtttc atcaactttg 113460
tcaacttgtg gtgagtacct gatttatgaa tggtcgaaca cgcatggcga gaatagtgag 113520
atttacttgg tcttagcagc attggtactt tacatggagg aaggggaccc ttggtcacat 113580
caccctactt ttcaagctgg gactctggat cactgtggct gtatggaagg ttacagctag 113640
ctgggagagg catcaccttc ttattctgct actcaggtat tggtgaaaaa cagccatgag 113700
tggtggagag gctgctgtct ccagacttcc agtacctggt acaagaaata ccaggttaaa 113760
cttctaggtg agactgatca tcttactcta atgtggttct cacaatgcaa ttgcaccaaa 113820
atcacctgga agcatttact gaatcaagag cttgccagat cagactttca gggttggatc 113880
tctgttctga cataacatag aaaacagttg gttatatgta gtagggtcac atccacacgc 113940
aaagtgtagt tggtagaact gtatatcttt gctctctgaa accttactcc aaggaagatg 114000
tgaaccccac acctgttgtt gtttgtctac ctttttaata gtttgttgtg tgtttgtgta 114060
tatgtagcac ctaagaataa acatatgcag atatggcagt aatataatca tgctttatac 114120
tgttttaggc tcttttaaat aaaatctttt tgtgttatca tttggatatt tttgacattt 114180
attttgttta tccaacatga tttaaatata agacatgcta tgaacaaaaa gcctcagagc 114240
attttgtgta tcttctgttt attcctgaaa ataccttttg gtttctcata attttttcct 114300
gctaagaatg cggtttctcc tcattttagg tcttatagac ttaaatcagg gtctaacatt 114360
gccctccttt gtatgaaaaa tttaaaaata tttgtttgac tatagttttt aagtctcttt 114420
catcttctgt aaccaaattc tacttttgtg ttggtttttc agaggggaga ggaatacttc 114480
aagattttct aggtagaaga aggacataag gatgactcaa attggctgct tcctcctttt 114540
aaaaaacaat caattctgta ctaatttgca cacagtatgg atagtttata taattgcata 114600
aatgtgatca ttttatgtat ttcattttta tgacatattt gcttaaaatg atctgtgtaa 114660
gtcatagggt ataatatcta aaatgatcac ctgtgaacct tccatcaggg tttcttttta 114720
actccttgat ctctttattg gttttgttct gtatgtgttg gtacttgtac atgtttattt 114780
ctgtttccct tgatgccata atagagtgac agttttagac attggagtcc cattgttttc 114840
cctgagtagg ttcatagttc catgtcattg caaatcatta aggtctacat tgaagtgtac 114900
ttatgttcat aatatgctca tattagctct ccacatttgt ccattctttc tgccactctt 114960
tgtcttggac attgcctgta atctctaacc tggatcattc agatttctca taatccaata 115020
ttgattttct tataatccaa tattgtcttg ttccaaatta ttcccctttt tattagagtt 115080
gtatttttta tgatgtatat ctgatcatgt tacttctcta tctaaagtat gcattcttag 115140
cagggtgata ttgaccctaa ggaggcaaaa attgattttg gagaaatgaa aatcttaggt 115200
tgtataatgg tttttagtcc tccaaagggc catagaatat aaacagatat gcactatatc 115260
tatcatattt aaatttcatg atggggagga taaataatga aaaaaatact gagagatact 115320
attctataga gacttcctct tgtccttaaa attaattaat ttaggctttc agaacccatt 115380
acgatctgga cttagtttat tgctctggtc acatttcttt tttttttttt ttttctttct 115440
tgtttttttg gagatggagt ctcagttgcc caggctggag tgtaatgatg tggtcgcagc 115500
tcactgcaac ctccacctcc cgggttcaaa cgattcttct gcctcagcct cctgagtact 115560
gctgggatta caggcacctg ccaccacacc cagctaattt ttttttttta agtagagaca 115620
gttttcacca tgttggccag gctgatctcg aacttctgac ctcgtgatct gcccgcctcg 115680
acctcccaga gcgctgggat tacaggcatg agccactgcc cccggcccgc tctagccaca 115740
tttctcatga cttccctctc cttgaatggt ttctgccaaa ctgaatttct tcagttacat 115800
aaattaaaag cacatacagg ataatatggg agaatgtttt cattacgttt gggtaaagat 115860
ttctgaaaca gaacgtagaa agtagccaaa cctaagagaa agattgatta aaaaaaaatg 115920
gatttcatta aaattaagaa cttccattga ttaaaagaca gcactgaatg acatgccaag 115980
ccacacagta gaaggagata tttttcatac ttatattcga cgaaggactt ttacacagaa 116040
tatgtaaaga atacttaaaa atgtaaaaca cttatgaaaa ataacaacca aaaatagcaa 116100
aatacttgaa aggcacttta aagatgatat tcaagaggcc agtaaacata ttcaatttac 116160
tgcattcatt ctgcattatt agtaatcagg agacatgcag gtcagaacta cagtgaaata 116220
ccactataat taccagaatg accacagttt aaaatactga cagtaccaaa tattggtgag 116280
gatctgaagc aactggaagt ctcatacata acttgtagga gtataaatta gtacagttcc 116340
tttgaaaaac aagcagtatc cagtatagct gatctaatat ggttgatgta tacaccatgg 116400
ttcagcaatt caagttctga ctatataccc aacaaaagtg tggacataaa tacactaaaa 116460
gacatatgta agaatgtccg gaaaagcaca tttataacct acaattagaa actctctcca 116520
cagtagaaca gataataaat tgtagcatta tgtatacagc agtatatagc atcagagaag 116580
atagaaccat tgcttcactc agcaacttca gtaaatctca cgaatgatgt tgagtgaaag 116640
aagacagaaa gcagtatgta tggttctatt tctatatgaa agttaaaagc aaacaatata 116700
aggtattgga agtcagaata ttgttacttt ttagttctgc acttaggagt tgtgttttct 116760
gtatgtctgc ttcgattaaa agttttccta aggaaaaaaa aaaaaggata agacttaatg 116820
gttcaaaagg aagaccttgc cgactgaggt gtctgagcgc tcagcattgg gaaatggtcg 116880
actcgtgggt tgataaaaag aatttacaga caacagtata ggtttgaaaa aggaaagttt 116940
attagaaaga aagtatgctg cagaagagtg cagaagggtg ctgagcgtgc cacagtggat 117000
ttttccttag gggtatttat ggaccttaaa gcttgaggat aatttggacc atattagcca 117060
tgtaggtaac aataaatgat tacatttgta gtaattttgg ttccttaatg tcagcaagtg 117120
ttgcacagtg aatttcgaca tggcattctg gagatgtata gaaattctag ttacttacaa 117180
agtttttttg gggaaaaaat ctggaaccaa tgcctgcttt agataatagg gaagtctgat 117240
tacttcttgg gttttgttgt tgttgttgtt gttgttgttt ttaatatgga gccttgctct 117300
gtcgcccagg ctggagtgta gtggcgcgat ctcagctcac tgcaacctct gcctcacagg 117360
ttcaagcgat tctcctgcct cagcctccta agtagctggg actacaggct catgccacca 117420
tgcctggcta atttatgtat gtttaataga gatggggttt caccacactg gccaggctgg 117480
tcttgaactg ctgacctcaa gtaatccgcc cgcttcagcc tcccagagtg ctgggattac 117540
aggcgtgagc cactgcgcca ggctgggaag tttaattact tctgattttc cccagataag 117600
gaattttgct tctagattgc ctgttggata gtcatcgggt ggtttttgct ccttctgcat 117660
tcctcagata aggaattttt gtctctaggg cctgttcagt ggtcaccaag tgattttgct 117720
ctcctcagat ctcagcccat attttaaact gtttcccaat ttaactatct attgaaatca 117780
ccattggaat tttttttagg ggaaaaattc tttatttgtc ctgggggaag aaaaaacaaa 117840
aaatgttatt cttgaggaat ttttgtgaaa ctctggatgg ggataagact gaattcaggg 117900
atggattgcc taatccaaaa tttatcgtgt gcagagggga atataaaaag tcactaggac 117960
gatataagac ccatatacaa ctctgtagct tgggcagcag acctggaaga agaggcaact 118020
tgtgggactg cctaattgtg caactaatta ggcagtaaag ctcgatcctg aaatgtcttg 118080
aggaaatgcc ttctgtgcta gatctcacag gcagctggga cagtgtagta gtatctactc 118140
ctgcctttct cttagcagca agacctgtaa agaaaagctc aagctttgct gaaataactt 118200
ctaacaacaa cgcctgtgtt ggttagaggg cgggagcaca gtgcatgctg ttagagcaaa 118260
tgcaaaaatt aaatccctat agtaggtgat gatgctgcag tgatggctct ccacctaggt 118320
gatgatactg caatgatggc tctccaccta ggtgatgata ctgcaatgat ggctctccac 118380
ctgtttctca cagttaacct gaatccatag ctgagattaa ctgtgataaa gaaaaatcac 118440
taacagatga aaactttcag tgattcggag aattgtacct aagaaatcta aacaaatatt 118500
tcctttaaaa tgtcacagaa aaaaaaacaa ggtaaaaaat tgtaaggagg gaataatttg 118560
aattccagaa acgttatctt cagatagtaa acatgattcc tgaactgaat gggggaaaat 118620
ggtggcacac agcagattga gtattgcagg ttaaccagat ctgtaagtaa caccgtttag 118680
ttaatcttta agaataaagg gctaaaaaga tgaacatgag gtaaatggta agagagaaga 118740
aaaatccaaa atattctatt tagctgattg tagacaaaga attaaaatta aaattccttc 118800
tacttgaaga ataactcaag ttcttagatt aaaataccag accaaattaa acaagagagt 118860
agagggaagc cacatctaga tgtgttctga gaaaagataa gacttgacaa gttttcaatt 118920
aaaacacatg cacacaaatg tacacaaaac accaagtcag caatacctga agagcagaga 118980
aacagctata acaggaggaa tgtggttact tcacattact ttggtgcatt agatatcttg 119040
gacaacactt gcactgaaac tactaaaatg ctggataagc tttttatttt atttattttg 119100
agatagggtc tcactcactc tgtcacccag actggagtgc agtggcatga ttgcagctta 119160
ctgcaacctc aacttcccag gctcaagcga tcctcccatc tcagcccccc gagtagctgg 119220
gactacagga atgtgccact acacctggct aatttttgtt tttttgttgt tttttgcttt 119280
tttgttttga gacggacttt tgctcttgtt gcccaggctg gagtgcaatg gcatgatctc 119340
ggctcaccgc agcctcaacc tcccggtttc aagtgattct cctgcctcag cctccagagt 119400
agctggatta caggcatgca ccaccacacc tggctaattt tgtattttta gtagagttgg 119460
ggtttctcca tgttggtcag gttggtcagc tcttgacctc aggtgatccg cctgcctcgg 119520
cctcccaaag tgttgggatt acaggcgcga gccactgcgc ctggcccacc tggctaattt 119580
cttaaaaaaa tttttgtaga gactggattt cactgtatta ccctggttgg tcttaaactc 119640
ctaggcttaa gcgatcctcc tgcctcggct tcccggagta ttgggattac agtggcgtga 119700
gccactgtac ctggcctgga taagcatttt aaagtgccat ttatttattt aggacagagt 119760
ctggctctgt cgcacaggct ggagtgcagt ggcatgatct tggctcactg cagcctccac 119820
ctcccaggtt caagtgattc tcctgtctca gcctcctgag tagctgggac tacaggcacg 119880
caccaccact cccagctaat ttttgtattt ttagtacaga cagggttttg ccacgttggc 119940
caggctagtc tcgaactcct gacctcaggt gatccgcctg cctcagcctc ccaaagttct 120000
ggcattacag gggtgaacca tcgtgcccca cctaaagtcc ctcttaaaat gtaaaagagt 120060
tggtgcaaaa ctgaggaatc catggagctc tgaagttgac tgaaattcag ggagggagat 120120
tatgggagag aaggaagagt caaagtaaat taaaggataa cccaagcaaa tgtagatttg 120180
ccatctaaat tcatattgaa tatggtaaaa atacttagag aatttaattt taagaaaaat 120240
tacttttcag agtccctggt tggaaagata tgctcctctt gcccccagtt gatgggcaga 120300
agcaaaagca aatcattcag cctaggacta aatgattcca aaaaataaag tcaagtggaa 120360
tatgtagtcc acaaaaaaat ctcaacactc acaaaagaaa tgagaatcag aaacaatgga 120420
tagtaggaat agatctgcaa aggcttcaaa tattggaatg aaaggaaaca aaaaataagt 120480
ttaaagaaaa agaggcagct tagaaatata agcagggaac acatttataa agaaccaaat 120540
agaacttcta gaaataaaaa gcataaatta aaacaatagc tgcattcaac agattagata 120600
tcattgaaga gagattaatg aactagaaga cagagctgaa gctctcccaa taaaactttt 120660
tgagatgctg gaaatgtcct ataatctgct ctgtctagtg tggtagctgc tggcatttga 120720
aatgtggcta atgtaactaa ggaaatgcat tttttattgg aattaagttt gctaacggct 120780
accttattag atagtctaag gggagctaat ataattattg ataacattat tagtgtcagc 120840
tgtaattcag aaaaagaaga cagtcaatgt taatagttta agatttcaac ccaaatagca 120900
tcataagttt atacactgac ataattttct gctccagtag atgaaataga aaaacacaaa 120960
accagaaagg tatggcagct ttacaaagaa agcaaacctc tgtgtgggtg aaaaaatgca 121020
acaaaaatac tgacagaatg ctgtgtagat ctgatgccat ggacttgctg tattccaggt 121080
catttttcat tctggagaat gaaaaaaatg atatcagtta cttcctgggc cacagcttta 121140
agcaagctat ggtactacac aatgacaagg ctttagatac tggttttgca accagaggac 121200
tggaactgta attgtcctaa taccaacata ggagtggaac ttgaaaggtc cattacagga 121260
ccctgtttga tactggtggc cctgtgaaat agaggcaact gtaaaactgc tctatgtgtg 121320
tatccctggc tcccagttca gttcatagtg attagtgggg cactcagaca tatgttgaac 121380
aaatgaatgg atatgcatgg agggtaaaca tgttatttca aaatgagtct gcaaatcata 121440
attcttgaat actgaagtgt aatgctaaga aagcatttaa caaaatggaa cagaaactta 121500
ctttaagttg aaatagattt atgaaattgt ctgaaatatg ctgtaaaaga aaatcagtat 121560
atttaggatg ctcaaggaaa taaaggtata aattcaatta aaactgagga agaaataaag 121620
tggttggaaa tagaagtctt ggaaatggaa aaatcatagc tgttgatata aaagacacaa 121680
cagacttgat gttctctaga ctggaaataa ttgaagacaa aattagggaa ataggagctg 121740
agacgttccc ccagcatggc acagattata tgaaaagcag tgaagaatca gaacagattg 121800
cagagttaga ggttctaaga tgcatgtaat ggaaataaag aaggcaactc tgaaagtgga 121860
gaagcaatgt ttacagagat cataggggaa agaaaacatt tgagaactga tttagtatag 121920
gttttcagat tgaaagtgaa gtctctttat catgtaggat aaacaaaggt ataagcttaa 121980
aggtaaattt aaatataaat ttaaaagtaa attttaattg atattctgta gttttgcttc 122040
agtgcataaa tgataaacaa aggtataaat ttacctttta aatttatatt taaatttacc 122100
tttaaattta tacctttgtt tatcatcatt tatgtattga agcaaaatta ccgagcaata 122160
tcaggaagag aaaacagatt atctgttaag gattgataat aagactaaca gcagatttgt 122220
tcccagccac aatagttgca ggaaaaagtg gagtcacagc accagagtgc tgagggaaaa 122280
taattgtcag cctggtccta aagttttaga ctcagacact caaatattca cagtaaggaa 122340
gaaatacagt tttaggaatg ggaagactga gcacttacaa tttatagact gctttgatcc 122400
ttgaatggtg tggaggttag ggatgctgac cccctgtaca gtcaaaaatc cgcatataac 122460
ttttgattac cccaaaactt gactactaac aaatagccta ctgtcaacca gaagccttac 122520
tgataacata gttaacatat attttgtata tgtattatat actgtattat tacaatgaag 122580
taagctagag aaaagaaaat gttattaaga aaatcataag gaagagaaaa tatattattt 122640
atgaagtgga agtggatcat cataaagatc ttcatccttg tcttcacatt gaatagactg 122700
aggaagagga ggagttggtc ttgctatctc gggtggcaga ggcagaagaa aaatccatgt 122760
ataagtggat ttgtacagtt gaaatctgtg ttgctcaagg gccatctgta cttgaccaag 122820
aagagaagtt aacccagaag aaggatgtca caggttggat gcctggaaag caggcttttg 122880
agacagagat aagagtgtag gaagttgact aggtagtgat cttgggatca acactaccaa 122940
tgagaaggaa acgagattgg gcagaagaag ttcagttgca gtgccatgtc attgaaggcc 123000
tcagccaact ctgtgttgac ctgccttgga atgagggtct tggattttta ttcacttttg 123060
tggatcagtc attagagatg gactgtccca ggagggctaa ggtggctgtc tttagctgtg 123120
gtaatcctga agaggccgat agtaaagggt tgtctgctgg cggcttgccc cacagtggaa 123180
gaataagtcc ttccttctta aagagggaat ctacatagca cattgcagta tctgttacag 123240
aaggtgtggg atatggaaaa cagcaatgag tttagaaaga ggtgaactat gttacccata 123300
ttaattcatg tttgatagta aaatattaat tgaggttgga agggaatggt gattaagata 123360
tgggccaaga tagatgaggt aaatataaac aaaatgaaaa tacttttggc agctttaatt 123420
aggcaaggta gaattcaagg agaaaatgtc aacagagcag acatttttat atactgatgt 123480
agtcttcagt gaagttatat tgttttaaac ttttggacca aagaacatat tgagatacag 123540
agtataaact tttttaaaac ttaaggataa attgataaaa atgtatatgt aatttatctc 123600
ccagaattac ttgattgctg gtttctcttg ggtagtatct gcataaatat ctgtctactt 123660
atttatttac atttagaaaa gcatatatgt acacaaataa ttttatactt ataaaacatt 123720
tatatattta actgtagtat tctgtgtagc tatgccataa tttagtcaat tttcaagaat 123780
taatattttt tctaattttt aactaatcat cctacactga ctatcctaga gataaatctt 123840
cagattatag actcacaatt ttttgtatgt gcttttactg tgtttagcag gctgtctgcg 123900
ttgttacttt ggatctgaag gaaagaacta tttcattatt tgtaatattt catctgtgaa 123960
aagaaaaata cttaggcaaa tgaatctaca ttttaataat gttattttta tgttatttta 124020
gccttacgaa ggatgaatcc aaaaggccaa agtataaaga gcttctggtg agtgtgggac 124080
tgtggggatt gtaggtacat cctaaccccg gaactctctt aacatgctgg ttcactaagc 124140
aagcagtggg cctctctgtc ataaacaaac atctcaaatt tattgagtgt tttttgttaa 124200
tgtttttaca caaagatttg gaaagagaaa atttgcagtt ataatttttc tactaatact 124260
agctaaattc tcatggaaaa ttttggtctt aacatgttat aaaaattacc cccaaagaat 124320
tctgacttta agaagccatt ttccactgca tagtctattt atatgggatg cagccataag 124380
aaaaaaatta gtgaaaattt gtgtttattc tgcctttata aaattcatgc aaatttacgt 124440
catatagcct attcccattt ctttgaaagt tctcattcat cccatggaac ttgggtgttt 124500
taagcagtct actgggtatg gcattggtgg ggcagggaga aagtgttgtg atctaataat 124560
gtgggaatat tttaagaaaa gatccatttg tttgtcacat ttaactacta gctcttcaag 124620
gatgttgtga caaacttata tcacagtcca ccaatgactg taaaaatatc tagtcaacat 124680
acttagtctg taaaagaaaa ctgttgctag agatggagtt ttaaaaggtg ggttagtgaa 124740
gcagatactg ggaccctggc tctggagagt acagggaaga agctcctggg gcaaatttct 124800
cttgggcctc ttttggtcaa aagaattaca gcctttttgt taaaaggtca aaagaagagg 124860
tcaaaaggat tgcgaccttt ttgtaaaaag gtcctcctgt tgtatatagg agaaatggag 124920
gttgagattt atattggtgt cccaagagga atagtgactg gcatttgcgt cattcttctt 124980
agctcttaga tggtgtggtg gaggctccag ctatgttttg tgctgagtga caacttggct 125040
gtcttcctca acaaacactc cctggtatac agatgagttt ccagacctca ctgccaaggt 125100
ggcaccttca gatcattacc acgtatcctc tctctaggca tgcccatgcc cattagcata 125160
tctgcatgga ataaaggctg tactcgcctc tctgaacttg tagtgttgcg gtatttcata 125220
gctatgtgtg gttgggagcc tggagttcta tgttctatag aaattggaaa atgttcagtt 125280
tgggctgtca tacaaacttt tgactttttt gttttcaatt ttcttgcaga aacatccctt 125340
tattttgatg tatgaagaac gtgccgttga ggtcgcatgc tatgtttgta aaatcctgga 125400
tcaaatgcca gctactccca gctctcccat gtatgtcgat tgatatcgct gctacatcag 125460
actctagaaa aaagggctga gaggaagcaa gacgtaaaga attttcatcc cgtatcacag 125520
tgtttttatt gctcgcccag acaccatgtg caataagatt ggtgttcgtt tccatcatgt 125580
ctgtatactc ctgtcaccta gaacgtgcat ccttgtaata cctgattgat cacacagtgt 125640
tagtgctggt cagagagacc tcatcctgct cttttgtgat gaacatattc atgaaatgtg 125700
gaagtcagta cgatcaagtt gttgactgtg attagatcac atcttaaatt catttctaga 125760
ctcaaaacct ggagatgcag ctactggaat ggtgttttgt cagacttcca aatcctggaa 125820
ggacacagtg atgaatgtac tatgtctgaa catagaaact cgggcttgag tgagaagagc 125880
ttgcacagcc aacgagacac attgccttct ggagctggga gacaaaggag gaatttactt 125940
tcttcaccaa gtgcaataga ttactgatgt gatattctgt tgctttacag ttacagttga 126000
tgtttgggga tcgatgtgct cagccaaatt tcctgtttga aatatcatgt taaattagaa 126060
tgaatttatc tttaccaaaa accatgttgc gttcaaagag gtgaacatta aaatatagag 126120
acaggacaga atgtgttctt ttctccttta ccagtcctat ttttcaatgg gaagactcag 126180
gagtctgcca cttgtcaaag aaggtgctga tcctaagaat ttttcattct cagaattcgg 126240
tgtgctgcca acttgatgtt ccacctgcca caaaccacca ggactgaaag aagaaaacag 126300
tacagaaggc aaagtttaca gatgttttta attctagtat tttatctgga acaacttgta 126360
gcagctatat atttcccctt ggtcccaagc ctgatacttt agccatcata actcactaac 126420
agggagaagt agctagtagc aatgtgcctt gattgattag ataaagattt ctagtaggca 126480
gcaaaagacc aaatctcagt tgtttgcttc ttgccatcac tggtccaggt cttcagtttc 126540
cgaatctctt tcccttcccc tgtggtctat tgtcgctatg tgacttgcgc ttaatccaat 126600
attttgcctt ttttctatat caaaaaacct ttacagttag cagggatgtt ccttaccaag 126660
gatttttagc cccaaatctc tcatattcgc tagtgtttaa aaggctaaga atagtggggc 126720
ccagccgatg tggtaggtga taaagaggca tcttttctag agacacattg gaccagatga 126780
ggatccgaaa cggcagcctt tacgttcatc acctgctaga acctctcgta gtccatcacc 126840
atttcttggc attggaattc tactggaaaa aaatacaaaa agcaaaacaa aaccctcagc 126900
actgttacaa gaggccattt aagtatcttg tgcttcttca cttacccatt agccaggttc 126960
tcattaggtt ttgcttgggc ctccctggca ctgaacctta ggctttgtat gacagtgaag 127020
cagcactgtg agtggttcaa gcacactgga atataaaaca gtcatggcct gagatgcagg 127080
tgatgccatt acagaaccaa atcgtggcac gtattgctgt gtctcctctc agagtgacag 127140
tcataaatac tgtcaaacaa taaagggaga atggtgctgt ttaaagtcac atccctgtaa 127200
attgcagaat tcaaaagtga ttatctcttt gatctacttg cctcatttcc ctatcttctc 127260
ccccacggta tcctaaactt tagacttccc actgttctga aaggagacat tgctctatgt 127320
ctgccttcga ccacagcaag ccatcatcct ccattgctcc cggggactca agaggaatct 127380
gtttctctgc tgtcaacttc ccatctggct cagcataggg tcactttgcc attatgcaaa 127440
tggagataaa agcaattctg actgtccagg agctaatctg accgttctat tgtgtggatg 127500
accacataag aaggcaattt tagtgtatta atcatagatt attataaact ataaacttaa 127560
gggcaaggag tttattacaa tgtatcttta ttaaaacaaa agggtgtata gtgttcacaa 127620
actgtgaaaa tagtgtaaga actgtacatt gtgagctctg gttatttttc tcttgtacca 127680
tagaaaaatg tataaaaatt atcaaaaagc taatgtgcag ggatattgcc ttatttgtct 127740
gtaaaaaatg gagctcagta acataactgc ttcttggagc tttggaatat tttatcctgt 127800
attcttgttt gaattcctcc tctatttaag atatatacat ggaatcgaag tgtttatgta 127860
atagttctat ccttttgcct gcaggtcagt tgtaataaat ctaggatgtg atgatgactt 127920
tgtaatttga ttttctgaaa tcagaccctg agaggggaaa atcttaaagt aaattacatt 127980
aaattatctg tgcatttcac accagggaaa atgacctcct tttggaagtg ttttatggct 128040
gctttctttt tcttcttcct tcccatggct accctttttg cttatccttc ttgaaaccac 128100
agatgtatct gttaagcata gctttgcttg aacaggtgtc acagtctctt gagtttcttt 128160
gtttgttgtc ctgacctgcc ccagcattct taatgctaaa ggaagtgggt acagttcttc 128220
aacctgtgtc atggtggaga ggtacaactt ataagtctat ctgggccccg tgtatggttt 128280
ccagccatgc tctccgctct tggtgcttca gctgccaggt gagcattaga tgtcaggtta 128340
gatactgggt tggaatcact cactgttacc ttagaagggt agggaggatt gtgggtagaa 128400
gacgtctgga ggtcagacat gggaggttta tggatgagag gacaatggaa gtgaacaaaa 128460
agccatggga gcctgaaaac tgttggagaa aagcactttg cggctccagc actgaatgta 128520
tctgctgtac tctacctcct accagtgatt gatcagataa cagattcatt gatattatgg 128580
tgattcagca ccttgccctt gtgcctgctc ctaactgtac ctgagatact attacacagc 128640
cagatgtggt atcaaacatt cccctgagag gggtgtgaaa gcaggaattc tggcctctcc 128700
agctaacctc agctgctaag ggaaagggta cccattgggt ttcaatactg gcatgagaga 128760
tagactacac actccatgtt tcataggaca ctgccttgta tttgttcatc tcatttgatt 128820
ccaaatgcat cccactaaaa tcaagtggct gtatcccctt ttagatacaa gaaaaccaag 128880
gtccgaagga gtgaagttct ggctcaaata acagtaggga gcagagctga gattcaaatt 128940
caaggccgta acacgtaccc taagaagtta cattaattta aaaacactgc tattaaagaa 129000
gtgttgtgga gttgagaagt ggaagaatga atatagttga ggatactctg ttcataaacc 129060
tgaccagggc ctgctttgtt gttttggaaa tgagttgaag gcagaggttc tgggggccac 129120
agtggggctt aacatacaaa gcgatccata caaaggcaac tgtgtaatta ccttagaatt 129180
aactagagga actctaggtt gtaattcttc agtgcaaaca cctgagaatt cagtgtcatg 129240
gactgaacgt ctccattagc atgataatgt ggcaatcact gagaatgagt aaagtgccct 129300
ttcatttatt ttatttattt tttatttttt gagacagttt tgctcttgtt gcccaggctg 129360
gaatgcaatg atgtgatctt ggctctgcaa cctctgcctc cggagttcaa gcaattctgc 129420
ctcagcctcc cgagtagctg ggattgcagg tgcacaccac cacacctagg taactttttc 129480
ttttcttttt tttttttttt tttgagatgg agtcccactc ttgtcgccca ggctggagag 129540
caatggcgta atctcagcac actgcaacct ctgcctccca ggttcaagtg attctcctgc 129600
ctcagcctcc caagtagcta ggattacagg cgcctgccac tacacccagc taattttttt 129660
tttgtatttt tagtagagat gtggtttcgc catgttggcc aggctcgtct cgaactcctg 129720
acctcaggcg attcacctgc ctcgccatcc caaagtgctg ggattacaaa gagccagcat 129780
gcccgacttc cctttaattg attcgatcca actgtcttag ctgcaggagg atagagaaag 129840
gacacataag gtcttgaaag taccgttggg acactggtta cttttcttgg cagtgtgtag 129900
agattatgtg tctccatctc ttgtgcaggg ctgtctgcac cagtcacatc cattgttcct 129960
gggcttattg cttgggatgt gagggacaga gaatctaaag gctttgtctt aaac 130014
<210> 4
<211> 88080
<212> DNA
<213> 智人
<400> 4
gcagcacatg actataattt atatccattg catttcttat ttcctgaaca tacacatgtg 60
gattattttt cttatatatt aatcctgacc taatcaagca tttaacaatc cataaaactc 120
attggtgtta ggtactatag ttctaggtct gcactgtcca atacgtcagc tacctgtgac 180
ctttgagcac tcaaaatgtg gctagtctga attaagatat tagaaatggt cagtgtaaaa 240
cacacaccag atttcaaagc gccagaaaag agaaactatc tcattcgtaa tacgttatac 300
attgattgat tactcgtgga aataattttt tggatacgtt atgtaaaata aaatgcatta 360
ttgaaattaa tttcacctgg ttttaaatgt atctactaga aaatttaata ttatatatgt 420
ggcttgcact atattttgtt agacagcact cttctagtgc atgataattt ttgaaaattt 480
ttatttattt atttattttt agagacaggg tgttgctctg tggcccaggc tggagtgcag 540
tggtgtgatt atgcaccttg cagtctggaa ctccggggca taatccaccg tcccatctca 600
gcttcctgag tacctgagac tacaggtgtg tgccaccatg cccagctaat ttttttttta 660
atttttgtag agatgagggt ctcactatgt cacccaggct ggcctcaaac tccaggcctc 720
aagtaaccct actgtctcgg ctttccaaag tgctgggatt acaggcgtga gccactgtgc 780
ccaaccccat gccaactttg tatacctctt tatagcagct ttggccataa aacaatggaa 840
atcaattgca aagtgaaggt gcaaatgttg caaaagatgc agaagtgaac agagccaatg 900
aaagtggtcc tgaactgctc aggtcacatg caaagccttg tgaatgcagg attcagcaga 960
gttggaccag gaagttggta aaaggaagaa aaaactgaca aggacactag tctaaaaaaa 1020
gcaattgagt attacaggag gatcttggga aaatgtatga acccttcaaa tattgtttgc 1080
aaaaatgata gccctcacta agccacaaag gtcaaatgga aaaagagtat ctcagcatgc 1140
atcaaaaaac agcaactacg atggccattc aaagaattca gagaatcagt gcaagattgt 1200
aaagtgagaa gaattttgct tactctgagg caaattaaat ttaataagtt gtagttgtgt 1260
tcttaaatat aaaatcccaa gtacttttca ttatttatta caaaaattaa tttctgattt 1320
taagaacatg caaatacatg caaaatgttt agaaggttta ttaataagag ggaatcatac 1380
gtatctctta agtattttac tttagcttaa aacatataaa caacagtgtt ttgttttggt 1440
tggtttgggg tttttttggt caatatttgg ctgtaagtct ttagtcttta aaatgtgggt 1500
tcaccgttta gagttccatg tatctttcac atcatctaca attttcagtt ttagtttttt 1560
taaagtgact actgatagat acctgcaaag taaattcttc ccaatctttc ataatggtca 1620
tacccacaac taatttgaca gattttttca gtgcctcgcc tcaaatactt cctattaaca 1680
tatggtaaag gaagaacacc ctttcaatta agcatgtcct ctgatcattt ttctcttaaa 1740
aaatcagtgt gtccatatgc aaatgcataa tgacaacctg aatattcaca taagtgatta 1800
aaataaaaat gactagaagc atcaaaaact attggaaaga ctggcactta ggtttccccg 1860
tggtggtatg cggtggctgg gaagaagtta gagaattgtt aactagttga taagtgttgc 1920
actgggtact gcctcacttt gatccccagt ttcaatcact tttctctcaa agcatttcac 1980
ttcattttca ctggaacaac tttcttttcg cacacacata ctcatgtttt taaatttaat 2040
aatcaattgt gtaatattta attaaatttc acaaggaaca ttgtaatagg tggaatcaag 2100
tttgggaaca agcacaatgg attctcatgg gacccataac tcacctagtg ggaacagaag 2160
tatgcaggtg cacaccagcc gctggcctga gcatttattg tgctgtatca tccctctgca 2220
tgttgtacac cacacagtaa tggctggtat ctgttactgg atgagtcagc taaatggagg 2280
ctggttaaga gaccttctac tataatgtca tttacagtgc ccttgtaggg aaccaattat 2340
cccactgatg acaggatttt ctgacttaga acatctgaaa acacctggga agtatgttgt 2400
ctggaaagaa catgcagaaa ccaaattcta gccccagcac tcctgcaagt attccataat 2460
aaatatttgt aagcttgaaa gaacaccagc ttttacccta ttctcaaggt tatattattc 2520
ttttatgttt atctgaggta tagatctcac aaacagccat gaatatgtga atacattcac 2580
atactgatgg atctggaatt ctaccagtca gcctgataaa tacccactaa taaaaatatc 2640
tgtagattgg aatattttgt ttattcattt ttgtagaaat gaaaaacaac aaacaatatc 2700
ctcagagaag aaaaattcct gcatatgcac agtaggtgct tactaaatat atgatgaatg 2760
atgtacaggc tgaaatattt ctcccaatgt atattatgtc tgctcattct aatatttgtg 2820
atatttatgt acagtgagga aatgcccagt gtcaaagtgg atcctcaacg tgaatatgct 2880
gcaggaactg aagtgtgatg taggcagttt ccagaagcac tatgtggagg cagtgatctg 2940
taatgcactg gtattaaggt tattgaaatg gtcatgaaat tgccatgaaa ttgcatgcgt 3000
gaaatcattg caaggtttac gtcccagtga ggatggaaat gaagagcttg gaaacaggaa 3060
ttggagcttt cagtctagaa acaaccttgg aagaaataca agtctcctga atgttattaa 3120
ataaatcata ttaagagaat tcagagccta cagtacttga tatttgacat ccacctctct 3180
gcagtaacat agcaggactg aagagcacca aaaccagcta gagtcttaat cacgcattag 3240
actcagaaac ttctattaac atatggcaga gggagaacac ccttttcagt taagcatgtc 3300
ctttgattct ctctttaaga aatcagtgtg tccatatgca gatgcataat gacaacctga 3360
atatttacgt aaacaaagaa aaaaatgact caaagcaaca aaaactgtgg gaaaatacca 3420
acacttaggt ttctccatgg taatacgtgg tggatggagg aagtgagaga attgtagcta 3480
gttcatagtg ctgcgctggg tagccctctc cctttgatcc ccagtttcaa ccactgtaca 3540
aacagtcaaa aatcagtttt gctggaatct cctttttact ctgctactct ggctaaagtc 3600
ttccacttac ttttctcact tacaggtacc tgaatatgtg cgtgcaaatg taaaagtctt 3660
tagatcaaaa taggaacaag gaaagtttat ccgtttcagt ttaggatttg gtgggtgtgg 3720
caacccagga agacctgaga aataaccact gtttggtttg aatgatacat ttgactgcca 3780
ttaaaatagc atataattat agcctaaatg tagacttaat ttttaacaga tttatctgaa 3840
ctttcaaaat ttgtaccgtt gggtgtaacg atctaaaact atcttatggg agatgttaca 3900
gcagttttca aatcattgag ctaatatgaa atctggactt tttaaaaccc ctctgatcta 3960
acctggttac gcagttaaca ttgtatctgg gaaaggggct ttcattttac ctagtctcca 4020
gaagtcaatg gaattattct gtaaatagtt caggcttttg tctaaatatg tgaagactga 4080
caagactatc tccgtgagaa tccgcacccc cccaccccaa cctcccccct ccttaatcat 4140
gtttcacaaa gtaaatctat agacgttcct cctgggtttt gggagattcc ccatcctaaa 4200
caaaccagct ggaggaaagg aaaggaagga agaaataaac gcaacacaga agttctcctc 4260
agttgacaaa aggtcaaaaa tcattaacgt gtaaatgttg ctttttccat cccaaagcac 4320
cttctcacgt agagtccagg gactaggagg actcacaacg cagcgatggg cagccaggcc 4380
ctgcaggagt ggggacagag ggaacccggc cggtggcccg accctgcagg gaagaaggac 4440
gtgcggcgag aagcatcgga ttcggggagg gccgggacct ggccgagggt gacattaccg 4500
agcacttcct ggcacagcgc tggtcccctc cccaaacgcg ctatatgtgg ttctgtacgg 4560
gactgccttt cccaaagaca gccaaggaaa aactaaagat cgacggggac acccgcctcc 4620
cttcctcgcc ccaacggttt ctcagaggct gtggggactt ggtgagggta gggggtagtt 4680
gtcccaaatc agcagcttca ggatgtaagg tattacagaa aactttgaag ttttgttatc 4740
tgtagcacag ggacaggggt gggacaatag agaaggaatg ttttcttttc aaaagaaaac 4800
acaaacaaaa ctttattttt ctggtccgcg gcagcctgtc tgctgaacgt tgacttgctt 4860
tcgctttgca gcaggcgacg gtcccgggcg ccacctgcgc gtcggtggga ggctggtcca 4920
cgcccgggtc ccccgacgcc cactgcaaag ggcagtggga atgacagact gtaaaccctc 4980
tcgcctgcgt ccccttcaag caccagaaac ccaagttgga actaattctt tctttcggaa 5040
ggtgcaactc ccctcccgcg agctccgcgg tgccgggccg agattgccga gaggaagcgg 5100
cgcagcgctg ccgccaaggc tcctcctgtc gccggtgcgg ccgggactac ctggcggcgc 5160
ggcgcgtgca gcgcgcagag tcccgggagc ccacgcctcc gcctccgccc ccgccccctc 5220
cgcctcccag tccacctcgc ccgcccgccc tctcgcccgg cggagagcac agcccactcc 5280
ctcccacctg cggccgccgg gccgccctcc acccacacct ctgccgcagg ccggacccag 5340
tgcgcccgcc cgtcggtcag tccaggccag gcgcccggcg ggccgcgctc acgcagttgg 5400
cgcaggaggc cttacgctgg cggcgcagtg cccgccccct gcgctctccc cgccccctcc 5460
ctccctcgca ggggccgagc gaatgtagcc cgcgagagaa aatggcggcg gcggcgggga 5520
atcgcgcctc gtcgtcggga ttcccgggcg ccagggctac gagccctgag gcaggcggcg 5580
gcggaggagc cctcaaggcg agcagcgcgc ccgcggctgc cgcgggactg ctgcgggagg 5640
cgggcagcgg gggccgcgag cgggcggact ggcggcggcg gcagctgcgc aaagtgcgga 5700
gtgtggagct ggaccagctg cctgagcagc cgctcttcct tgccgcctca ccgccggcct 5760
cctcgacttc cccgtcgccg gagcccgcgg acgcagcggg gagtgggacc ggcttccagc 5820
ctgtggcggt gccgccgccc cacggagccg cgagccgcgg cggcgcccac cttaccgagt 5880
cggtggcggc gccggacagc ggcgcctcga gtcccgcagc ggccgagccc ggggagaagc 5940
gggcgcccgc cgccgagccg tctcctgcag cggcccccgc cgggtgagca gcacggccgg 6000
ggtcgcggcg gggacttgga gagcgggcag agggcaatga atgaaccccg ggcaccatgc 6060
acggcgtccc ggggttcagc gcagcgaggc tacgcgccgc tcgccgggac ctacgcccct 6120
gagcaccccc cgaccccttc ggagtcgggc ggcgccccgg acccagcctg ggggaccgga 6180
cggggacgtg cggaagagtt tgttattgtt tgcagacatg tgacaggcgt gcgagcctct 6240
ctgcggggaa ccgttgcgaa aaggtgtagg gggccacggc tggctttgtg ggactcctgg 6300
aatcggggct ctccgaggag cccgggggcg gggcacggcc ctgcggcggc gcccccggac 6360
gggtgtcccc ggggcaaagg cactgggggg cgaggcccga gcctgaggcg ggcggtggtc 6420
ggaagagggg cggggtgggt gagaagcccg aggtcgggtg ggagactgag aggaccgaag 6480
agaaagtagc aggtcccagc ggccgtgaca ggcagagccc ctcggcccgc ccgggactcg 6540
agtccctagg cagataccgc gggctgggcc cggacgcagg cggcgcgccc ccagcgccgg 6600
ccgcagggct ccaggaggac ggctcggtaa cgcctgtcaa agccgtgcgg cgggaggctg 6660
cacactcgcg gaggcttgca gtcttttagg aagtgcggtt tgtctaattg cagcccccaa 6720
ggggctttga gtgttcctgg gaatgcgaac tgcactgcta agtcacttga gtgacttctg 6780
tttggagttt gaatttggcc tttgaagttt gcatttggcg gagtggtgta agagccagga 6840
ccggatgtgt cagccattca gtttcaaagc agtggtgact gctccccgca gcccctccgg 6900
cttggcccgg ggactgcggc gcgggtgcag tgcttcctgc tcggtgccct ggcgcgggcc 6960
gcccgctgaa ttccaggggc cgcagtgcgg tgggcttcgg ctcagatgcg tcttctggtg 7020
catatgaagt acagtatgtg taaggtaatt tagaccagcg gtttattggc ctcgcccatt 7080
tttggctact ggaaattttt atgttaaagg aaattctttt aagtgtgaca gctacatcct 7140
tgtttgtttg ttttttaaaa acctgattaa cgtatgcaaa gtacaaagtc ttgatgggta 7200
ttttgagttg ctggaaatgt ttttgtgata gtccctcgtg gccctgtaga attccctgac 7260
ctttattatg agaagaaagc gtgtcatttt gtgagacgaa tttgacagta ggagtccttg 7320
gtttggattc attatctaaa gtgatctggc attttttgtg catttgatta tttgcttaaa 7380
atcacgatcc atttagtatt tggaagtccc cttcctctcc ccaagaacta aaaaatatgc 7440
ttcgcactgt accatggcac tactgagacc aaaggagatt tgtgactgat acagttttgt 7500
gtgcacttgt acatgtaatt tattcttaca agagttatgt acctctatag ttttcccatt 7560
tctgtgcaga ttgtattaaa acttaactgg aataattctt tgaaggcaac ttctacttta 7620
aatgaattcc agataaaaat ttttaacccc aaatttaaga aattgtatct attgagacct 7680
aactttttgg atacaataaa taatttagca aacgtcagca ttctagtact cttaatgagc 7740
tgtgaatata gtagaagagc atccactgta aaaataatgt actgaaattg tttaatgttg 7800
tctcttgaca caaaataaga ggactaaggt ggaggcagat agaatttagg gactaagtaa 7860
tccatgctta gtatttgcgt tttgtaaccg aggttttttc ccctttgctt aaggtgtaga 7920
ttataattgc acagtataag aaaataatgg gcttgtaagg ataatctttt ttaaagaaat 7980
tatttttacg agtcagaatg ctgttggttt atcccaaatg tcatacgtaa agatttcatt 8040
tatagtaaaa tgttgattcc ctaaccttat gaaatatagt gaattttttt ttcttaacaa 8100
ttgggttgaa attcatttga atctgttcgt ataaaacttt gtggggaaag ggcttgtatc 8160
ttatttgagt gtgtatattt tgtattgcat gttggttatg ctacactatt acttaccatt 8220
taaagtttta ggaaaaaaaa cccttaatta tagccaactc aataaaatat caattgaact 8280
ttatgtttta cttttttttg acagttaagt tacattcata cttccaagag gaaaatctaa 8340
gattttgaaa tatttgagag ttctgtgatc ttttttttaa ttttagaatt tccttctgat 8400
ctttgaatgt agaaaatata ctttgaatta gaatttatat aaataaataa tactcgtatt 8460
taaatagaag attttaagtt tgtccctctt tttcagggtg atagctgaaa tcagtgaaag 8520
tgcctgtaag tggcgcccaa gggtttggaa tttttcctta tattacagaa tttaggggct 8580
ttttcttcct atttactgtc tttgaagaaa aattacagtg ttactctcca ttgaacagcc 8640
tattgtgagt ttggtagata taattacccc atcctatttt tgtaacttaa aaaaccaaac 8700
tatcaatttg ctggccccgt gaaagaacaa gatatgctgt acttgttaat gttagttttt 8760
gtttaaaact aaaggtattt cacaggctgc ttttatatcc tcatatagcc ctcagatttc 8820
acttcctttt taaagctatt aggctaaaaa tatgatttag tgacctttta ctaaagagga 8880
ggtataagag cattattacc taaaaattac tcttaaaata ttaagtgggt gactttataa 8940
aaataaaggt agtcacataa gttagtcttc cgtgaatttg taagttttta gttaagaatg 9000
gtgtcagttt cattttaaat cagataagaa aattaatgca ttcttcaaag atgaacctta 9060
atataattct ggaagagaaa tataagagct agaattgttg ccaactttta ttttcttttc 9120
atatctgatt ttggcaagag tgactggtta accaacattc cttaatatac gatttccaat 9180
gcactaaaac tccattttgt tagatacgaa aaacaggaag tagccctgtt cattgatatt 9240
catttacaac ttccatagca cctcgagcat aatatgttgc atattttaga aatggccact 9300
gacttgtcaa cttgcagatt tcaaaatgtg ggaagaaagg agtgtttttt tgctttcaac 9360
aagagcaaaa aaaaaaccag ctacagcttg cctaggctga gtcggctaat cagtccttga 9420
cactggctgt gtgcatccca aaggaagaaa tgagggggtg gcaaggtagt taatggggaa 9480
tggattacca tgaggaaaaa tatggggcat tcagaaatgc tctcaggtag aaagcacctc 9540
ttttgcattt tgtactccag tcatcttctt gggttgaggg ctgtctgtta cacagaaggc 9600
gatgggaaaa tgtgtcatgg aaaagtagta gtctctagag gctgcttagg aactgcgtgt 9660
atattacacc tctaatcttg gaattctttg cttctatcaa atatatcaag tatagacttg 9720
gttgttttcc ttagtccttg cctctttcta tatcctaagt taaaagctaa agcaacttaa 9780
acatgtaaat ggtagactat taatgtgagg aaatgtgtaa gattaggagt aacccaaagt 9840
tgtctttaag aaattattta agaacatgtt taatcatgaa agaaataatc agggccggaa 9900
ttagtaaatg gttcattgca aagcatgaga ttagtcagat actcttttca gtttgcaaaa 9960
atatattagg attttatctg tggcttaaaa catactcatt gagcatatag atatgcctag 10020
atacctttta cataatcaac tcttttgcct tctgtgtgtg tgtatgatat ctattatatg 10080
tattatatat atgtttatat ataatctcat ttgatcatca ctgcagcccc ctaagatagt 10140
gtaatttctg ttttctgtag gtgcaaactc atctgagatg gtaaaacctc atgattacac 10200
aactagaaga cagctaggat tcaatcccaa gtcagactga ctccacagtc catttctttc 10260
cactactctg cttcttccat tttctttttt caaattaata atcaaattaa ttgattattt 10320
ttaaggagaa atttgttttg caggcattct aatagaccat gagctaggtc tctaccctgt 10380
gctaagtttg cctgttaatg tatataatag gtatgtttct gtaacctggc cttgtatatg 10440
taatacaagt aaactgtatt tggatcaccc tatcatgtca gccaaagagg gttagtcatt 10500
agtgttgaat gtttcttaga tttattgatt tgtgctgtat taaatcataa gtgaaaggag 10560
ataagctgaa attaatatgg ttcattcatg gtaatcacac aggaagagaa acttttacta 10620
ttgctagacc ctaccccttt gttattgttt tagatttcat ccattcaaca tttatgaact 10680
tctgcaaggt ggtggtcttg agtggtggag aaaaagatca tgagtgcaca agctgtttct 10740
gtcggtaggt tgtagtatga acatgtttca caataccgtg ttaagtgcta taagagagat 10800
ggggatacag aggggataca acatattagt ttcaaactat ttctgcctat tttctgataa 10860
gaatatatac aacactgcat gttcaggcat gttttttttt cttccaaggg aaaattaaaa 10920
aggagatacg gggagcaaga aattcaacat ctgctactgc tagttctgaa attctgtctt 10980
tattattagt aacagcaact ctactagtta cgaaaacaac atggagaaat ataaaatatt 11040
ctttagggca taagatgatc aagaagatag ccttgtcttt atttactcta tggcatgtca 11100
ttggtgattg agttatgttt ggtatggaag ggagttctgt attgttagtg attgagtcct 11160
ttggaatacc aggctggttt gatgcagatg ttaatttgat cgagatgtgg agatgttgta 11220
gcatactaag gggaattgtt aaaactcacc aagtgtataa ttctgcaagt acacatctgt 11280
cacctgggaa ttactaagcc accagacctc ttgaagcctg gagaaagtgc ttggagccac 11340
atgggacagc ctacacagta ctgtagttag tacgttaact aagttcatca cttgtaagca 11400
taatgatgga tagacatgga gtgagaacag ggtcagtact ggggtgtagg tggaagcttt 11460
gctcttgaca gatgttatca ttacttttct ttttttattt ttaaattaga aatgggttct 11520
cactatgttg cccaggctgg aatcgaactc ctgggctcag gtgatctttc cacatagctg 11580
gaactatggg tgcaagccac tgtgtctggc tttacttttc ttcattgcct aaacaataat 11640
ttaagttata tgttaacaca taatcttcaa actggtctta tggtattctg aatactaaac 11700
atcagttgtt aacagaccag gaactttatc tgattctttg caccatctcc cagcatctag 11760
actagtgtct ggcacccatg aatattaggt acccagaaat gttaacatga attaattttc 11820
caaaagtggt taaattagta tatctgaaga ttaacttact gtagtgagat tttaatcatg 11880
atctagctta agacgagttt tgaaggcaag aactgtcttt ttttaggagt ttttgtatat 11940
cgtttggtat ttatttattt atttttgaga cggagtcttg ctctgttgcc caggctggag 12000
tgcagtggcg caatctttgc tcactgcagc ctctgcctcc taggttcaag caattctcct 12060
gcctagcctc ccgagtagct tgctgggatt acaggcatgc cccactatgc ccagttaatt 12120
tttgtatttt tttgtagaga cagggtttca ccatgttggc caggctggtc ttgaactcct 12180
gacctcaagt gatccaccca ccttggcctc ccaaagtgct gggattacag aaatgagcca 12240
ctgcggccag accattgctt gatgtttaat agcagtagtt ggcatttagc aagcagtcat 12300
tgataatatt gaccaatttt atgtaatgtg agccttctaa taattagtgt agttacaaaa 12360
taattggagc catgctcaaa ctgtcaaata ttgagaaaac tgaattcctg gtatttgaaa 12420
gtgtctaatt atttgcgtta attggtaagc ccctcctgat tttctactta accatgacac 12480
ttcttccgtg gcgcccatct tcattctctt gaacattgat actggaagat tcccagggtg 12540
gtcctaggcc ttctctcatt ctgtcttgtc gatccccacc ccagtcttat taatgccctt 12600
agatcagtta tggaccattt acaaatgatt gcagagttta ttgtcctaac catgatctct 12660
cctaaagtcc agacctacac ctggctacat gacttctgcg cagtcagatg tctaaaacca 12720
aattaaagat cttccctaaa ccttctccta acatgttccc tgctcattaa atggcagaac 12780
cagaacccag gagtcaccct tgacacctcc tcctctcacc tcgtcagatt cagaccatcc 12840
ttaggtgctg gcagtttgac ctgttatcac acccctagcc aggtgcccat tgtctctcat 12900
ttccactaac ttagtggcct ccttgcctga tccctgtgtc ctttctcctt tgctgtccgt 12960
tccaatctgt attaggtggc cagagtgatc atttccaaat gtaaatctga tcataacttc 13020
ctccctccag aaaagtaaat gtaatttaat tttaagatgt tcagatggct tccatttgga 13080
taaagaccag gaaatcttta acatgcctga ccgagtccct gcccggttgg gcccctgtct 13140
gcttctccag gcccatctca gctcacactt gcccttgttc cgtggcaggg ttgcgtgctt 13200
tcatttcctc agactcactc actgccttct tctatagggc cctcacatgc tccctctgcc 13260
aggaacactg tttttccata aagtcagctc ctcgttgtta aaatcttaac tcattgacac 13320
ttcctcaggg aagctttccc tcatccaccc agactggctt tgtagcaggg tgtccctact 13380
gtcagtgttg tgcttttaca tttgttacct catttgatga atgactgcct tccccctagc 13440
acctagcagg atgcctggca tagggtagac actgcataaa tatttattga ataaatgaat 13500
gagagggata atggcatggc atgttcaaat tagtggatcc actgtttttc ctgtttagtc 13560
agacgtagtt taggacatag ctgaaaaggt gttaaatggc aaaagtctag actatggtgt 13620
ttcaacactg tagatttgtg atagactcat tcagaggtac ctggacttgt agacgtgcct 13680
ggtggctcga gtgaaatagg acagcttaat gtagtagaga gcaaatagct atactgcatg 13740
acaactttat aggtaagaag agtctgctat gtgtatataa ttattctgta cttaataggg 13800
agttaagagt gcgtgtgtgt atatatatgc atttatatat tcacacatac atctgtgaat 13860
aaatatacac ataaaggtgt catgcattaa tataattatt cttattttta aagttctcag 13920
aatgtcatct aaacttaaga tatcattttt agaattctta tctgataacc ctacttcatc 13980
caaaattcat taatttgatc ataattcaac ttgggataaa taaaagttca catttccatt 14040
gaagaaaata tttgttaggc aagtactcca tgagattgca gaagccaaga acccatgtaa 14100
caaaacattt caaagtttac tgttggtaag taaacccagc agcctctctt atctagaaca 14160
tgggttagca ctaagaagta agaaaaaata ctctaagcag ccaaaggacc tgtaacaaaa 14220
tatgtgcttt gaagcacttt gattttacac ttagtagagt tcccagggca tttgctcagg 14280
attgatactt atttcagatg ttgttcatgc agtgttgttc atgtggtgtt cctaacatgc 14340
agcaattaga agcagccagt tagaaggggt ggcggtgtga gtcctgcaag aggcaggttc 14400
cccaaaggca gcagtgttgg cacacctgac agtgagagga gagagggaga ataggactca 14460
aaacattgca gtcgggggcc acctagcatt ggtacaatta gttccatcta gggcagcctc 14520
tgccatttaa aaatatactc agtgaagtga agttggaaag cttgtaatat agattaagga 14580
aaattactat ccaagatagt tatagaaagt gtcttgatct ttgaagtggt aaacctctaa 14640
ctgttctgta agatgtattt ctgtagcctt gatgatactg aataaatatg tactttagaa 14700
ttacataaaa atggatgctg cttaccgaat gtcttatcta ttatctgtgt ggagaaatct 14760
tttttgttat tgttgacctg agtcatttta taccttgcag tttctttaaa atgcataata 14820
atcaccacta ccactaatat actgatcttt tccggttttt taaaaaaaat ttttattttt 14880
ttttttgaga cggagtctta aagatatttt tcttgctcca agggtctaga ttcttctttt 14940
tttgttgttg ttgagatgga gtttcgctct tgttgcccag gctggagtgc aatggcacaa 15000
tcttggttca ccacaacctc cgcctcccag gttcaggcaa ttctcctgcc tcagcctctt 15060
gagtagctgg gattacaggc gcctgccacc acttccaact ttttaaattt ttgtattttt 15120
agtagagaca gggtttcacc atgttggcca ggctggtctt gaactcctga cctcaggtaa 15180
tccacccgcc tcagcttccc aaagtgctga gattacaggt gtgagccacc atgcccggcc 15240
aggtctagat tcttaaataa ccaaatttca agttttgtac aaagattgaa ggaaagctag 15300
tctttaacca ggaagaaaag gatttgttaa gagattatca gccgtatctt tgctgactca 15360
ttgatactgt ggtgcctaag acatcttggc ttttgtgaca gaatcctgca tacaactttc 15420
tccaggatag ttcctccagg agggacccct ctgccaggca ctgtggcagt cacatgtcca 15480
ggctgcatct ctgccctgct cagcctcttc atccttgcat tcagatctcc atgtggttta 15540
gggtgcccat cagggtaaac actgccattg tctctttaat tgctgtgctc ttactcttct 15600
ggctttcaca ccttcagctt ccaatcagtc accagttctt gttattgcca ctctcctagt 15660
agcctgagaa tccatccaac ttcctccact gccatgactg ctaacccagg gtcaggccac 15720
tgtcaaccca ctgtcaacct tttcttcacc ctcagaatga agtccagact ccataatgca 15780
gttcagaaac ccttaggact caggcttctg ctcactttca gcagcccctc agaatggtct 15840
gctcccgtca tttcagcatc gtgctcagtt ttagtccctc aactgaccgt tcttcttttt 15900
tttttttaaa gaaaacaatt tttatttaaa aatttatttt ataagaagta ttggcatgaa 15960
tacatagata aggcatttga aatggcttct ctggttggac tgttgaccag ctgaattcca 16020
gctctgtcct gcagctgatc acccttcttt ctcggcgtgc ccaatgctct tacctctatc 16080
tagaatactc tttccagctc cgtggtgagg ttttgtttgt tttgttttta ttctctttgc 16140
aataaagaat tattggtatt ccactaaaaa ataaatgtgg ctttgtagaa atcagtgctg 16200
tactgtgaat tctgccgagc tctggtttaa caagttcctc gatatctgag ttagatttgc 16260
tacttttaag cctttttagt ttttttctct atcattgtac atgtagtcag gtctttctga 16320
acgacagtgt tcacaaagag atgtttgtaa agcacacatt attgtaaagt gaatcagatt 16380
ttcttatttt gtgttaaaag ctcagagatg tggtctcagg gaaaaaatgt tgctgccaac 16440
ctacatatta ctgtccttga gaataatccg agaccttcac aggtcagaca acagatgtgc 16500
tcagatactt caagcagaga gcttgatgac gatgtaagca tcacaagatt tatgtcagct 16560
gctggacctc cacagacagg gtcccagcaa gctgacaggt tgtaggtgag caagcacgtt 16620
agatgtgcag gtcactcaca tccctttttg tgggatcaat ggatgttctt tcctgagaaa 16680
tgaaagggca gatgagtaag catgctagag catgtgtctt cagtcctgct gtcactcctg 16740
aggagatgtc catgccttca agaaacactc agagctgcca gccaggcacc aaggtgctgg 16800
ggacacagca ggagggaagt ctccatcact tgcctgtgga ggagcttacc tgatgacaga 16860
cagtgcaggc ccccgtccac tgtgagtcgg ggaggcatca ggaggctttt ttgggaaatg 16920
tgaggtggag caccaagcca agtcccgata aacgtggagg aatgaaccag gtgaaaggaa 16980
cttgcaagga ggttttgtgg cctaggggtg ggtggagaac acacaggccc agaaatcagc 17040
agtcttagga tggcatggag gactgcaagt gtagttcagg taactcggcc agagtggagg 17100
cagggtccag ggaccaagct gggacacgat ttctggctct ggccagagag agagccacgc 17160
agagctctct gcctcgtatt gcccccactg gccaatcctt gaatctcagc gcttaggaca 17220
aaataaaaaa gcctttgtaa tttgacaggt aaccacagag tgttaggaag tgggtcagga 17280
ggccccaaga aggatttaca tcagagctgg gacaagacag tctggggtca caaatctggg 17340
agctgtggct tttgtacttc agtagctcca tgtagtttca gaggttcaca gattgggaag 17400
tgttctcatg gcaaaatgaa ttccatccac tgtggtcctg aatgtggttt tggaactaca 17460
tgtttccatt tcagagacca tgcactgtag tgattaagaa cctgggcctt gctgggtgcc 17520
gtggctcacg cccgtaatcc cagtactttg ggaggctgag gcgggtggat cacctgaagt 17580
caggagttcg agaccagcca ggccaacatg gtgaaacccc gtctctacta aaaatacaaa 17640
aattagccgg gcttggtggt gtgtgcctgt aatcccagct tcttgggagg ctgaggcagg 17700
agaatcactt gaaactggaa ggcagaggtt gcagtgagct gagatcgcgc cactgctctc 17760
cagcctgggt gacatgacga aaactccatc tcaaaaaaaa aaaagaacct gggccctagg 17820
aattagacct gttagctact tggaccccag ggaagtcact tctctgaacc ttgaatttct 17880
tgtctctaaa atggggtcgt tggtggtata atgaagcacc attcttgatc cagaaaagta 17940
ttcagttaat actaactgta gataatactc ttgcaagtaa ctgtctatgc tcactactta 18000
aacctttaac cttttagaat gaggttaaga gcctccccca aggttgctgt gctacttatc 18060
actaggttag caaaggcggt ttgtgtagat aatacatcat cttgataaca atacattttc 18120
ccctgttatt ttgaaatgat ttactagaaa aatagaaaat ggcaactttc aaaattctgt 18180
gatatgggat aaagcatctc ctcagggttc ttatctctgt gacctaatgc aggtttcttg 18240
gtcttctttt ctcatctgtg aaaagaaaag gttggtttac ataatctctc agttccattc 18300
aagctctagc aactctccaa aaatttaact tggaaattac ttcttgtggc taaatttagc 18360
tgtaattatt gaaacaacaa ttagtttttt gaacttagaa actcttggaa ttttaaacct 18420
gggtaacaac tataaagaga aatgcaaatg aaaagcaaca aaagcttaga aaaaagaaat 18480
catgtttgtc aagcaacatt aagtgatgag aaaatctgtt ttttaaaaag cgtaataact 18540
gctaggagaa tattattttg caaattggag aaaataaatt aggtcaaagt cattagcatg 18600
tttgtgttta gcaaatacta ccttaggggg cagtttttaa agtaacttta attttttgac 18660
aactttgcta ttaaaagcta tctttttctt cttaatgtta attgtataaa gaagggacat 18720
ttttggatat aacctctaaa aaagcttctt ctttgacttc ttcttgtgtt tatttataaa 18780
gacctttttg taaataaaca tgtatgcatc tttttttttt aagttaaaaa tgcatcgctt 18840
ggtaacaatc atattgcttc ctaattgtga aaatttacat ttaattatat tttgggggtt 18900
ttttcatgta atttggatag agttgacagc tactagaaaa tgcaactgca tttcactatt 18960
ctattatttt gggctcaagt tctaaaaaat tatgactttc aaatagactt ggaataagac 19020
tgtttaactg atttaatcat tgtaattgca ccaacttgaa tcgtattcac agaaaccacc 19080
ttgcctattg ctgtttttct tctttttttt tttttcctct tttttctgag acagggtctc 19140
actccttcac ccaggctgaa gtgcagtgac atgatcatga ctcactgcag cgtcaacctt 19200
agcgggctca gtgtatcctt tcacttcagc ctcctgcgta gctgggacca caggtgcatg 19260
ccactgtgcc cggcaaattt tttttttttt ttttttgtag tgacagagtt tcgccatgtt 19320
gcctaagccg gtctccaact cctgggctca agcagtccac ccgccttggc ctcccagaat 19380
gccaggctta caggtgtgag ccaccatgcc gagcccgcat tgctgttttt tatacactga 19440
actgaaactg ttcataattc attgcagagc acacggacat tcagcagtaa ttattttttg 19500
tcttggattc ctggtagtaa agaatgcttg atccttcctg cttctgcccc aacccatgct 19560
agttcttact gttgtgatca gttattagat atttatttgg ggcacttact ctgtgctgct 19620
agcacgtgat ttccagataa ggctgtgatc aggaatagag caaagtcttg aatcttggtc 19680
acctcagcac cattctctag gtagttgtga ctgatggtga taactggctg taggttttgt 19740
taccagtaaa taaggcagct aagctgtcat ctgcacaatg caaactgaaa tcatcctgca 19800
gttttttaag tggatagtag gacattccct ccattgcaag atgatttgct aggagagttt 19860
taaatagtgc tgaagacaca cgagaacaaa gccttccctt tttgagctca ggtccaaaaa 19920
agcagttttg gcattaaaga gaaaaggttt atgctcaaga acttcttgct ttttcttctc 19980
cctcttactt cttggactaa gtgttggtga taagatacaa aaccgttggt gtctgaagta 20040
cctctgaatc cagcagcctt ctaaagaaat gttatcagaa ttatattgtg taatataatg 20100
ctttcttctt gttgaggatg ccccagaata ccgatagatg tcacagattt tgcagattat 20160
aattgtgaat ttaaaattta aaatgtcata tattttaatt actaaaaaca aattagtaga 20220
catttcttat ctgagtagaa gatactgttg gccataacct aatccaaaat gaaatttttt 20280
ttccccaagt tccgtctctg tttcttgttt tactttccct ctctctttct taaacacata 20340
catatactac ctaccccacc cccatgcata tacaggtctt tctaaattac tgccttttca 20400
ctccacatga ccaagttgtt ttgggacttg gtgttccagg ttcagtaagc ctcttacact 20460
gggttctgtg ctatagaaaa gttgctatag tgctggtaca cacacatttt cctgtaaatt 20520
tctcagttct ttatttaaaa ataaatattt tataaatcat ttattgagca ttgatagggt 20580
ttgtgtgtgt aatcagatgc tgtccttctg ctttatactt tggattacct gtactgtact 20640
ttttacacct agtctgactt cctgtcctta tactattggg ttacttctgc cccagctgta 20700
tcattttgtg tgtatttaga gcacatgagc taaatcttat attggttaaa gagtttaaaa 20760
atctgtcaca aaattttgcc caaagacaga aaattttatg ttgtcattta ctgttttttt 20820
tttaaatacc tagtctagga ttgatttttt ttttttgtaa tgcactatga gagattgcct 20880
acattaaaag cattggtaac agcacgtaaa tgttttgtaa gaagtttctg cgtaaggaat 20940
ataatatatt taaaatgtta attcattccc atatgcttaa gtagtcatgt gtgtcagatc 21000
ttttcaagta cagtgttctt gcattaaaat agcctagaaa ttttatttct gcattccagt 21060
tctgtcttct ataacttttt tttaacccgt gaaaatggga taaaatgttg ggtttttttt 21120
tttttttttt aggatcatgt gtgtgaattt gaggttcaga gactgcagtc actgcagaga 21180
cctgaaagcc attactgtct gtcctctgtg attatatgtg tcccctgtga ttcccacctg 21240
caggattagg aatgggaggg agagcagggg gtagaaaagg gaaggtggca gaatccatcg 21300
caaaccagtg aactccaaaa cctaatcagg cttctttcta ggcagattct atgagagacg 21360
aagacagacc acaaaaaacc tagccctaat ttttttttaa cccatgattt ctaatgttta 21420
tctatttgtt cattttgtaa ttcgagttta atcagaccaa ctatcaggca ggcatttagt 21480
ttgcactttc aaaaattgaa acttacacat ttattaaatg atatccagaa tcatttcctt 21540
tttcttttag aacattaaac attaatcctt ttgagtattc tcatgtattt caaggtactt 21600
atgattgctt atgtaggact aatgcaaaaa ttaaatgaat tccatgagaa ttcttttttg 21660
acctcacaag agttaaggag acctacttta tgtgaaagtg agatttttat agataatact 21720
ttgaaaacct aaattactct gatactaaac agtttactgt gtctgttaaa gtaaaaaacc 21780
taattgaatt gcagttgaaa ttcaagagtc tagacattcc ttgtgggcat atttgatttc 21840
ctctttcccc ttttagctgt tggagaggga attgccaggt gtctttagtg gaaagatatt 21900
taacctgctg tctgactgct tattgtggta gatgaagtgt tagcactggc tcaggcttgt 21960
gagaccgttc cccattactg tcctaacact ttggcaggat tttgagtaaa gttactttat 22020
ttaacctctt ttgagtttga cctcatctat gaattagaaa taatgatacc cttcatactt 22080
agagaatttg ggaagagcaa atgagatgat gaatataaaa acctaccctt tcagaagggt 22140
aaaaataaaa tactaggatt tatggtcata gcattttaga attcggaagg acaacctcct 22200
gactctaagc agtaaaagtg gcaagcaaag ggggttcagc cattgttgag agatttccta 22260
cttcagtaca gtgctgggtc tgggatccag cctcaatcat cctagttcac tgtcactctc 22320
ctactgtact tatctgaaat ggcaataata gttaacttcc tctgtgcttg gtacactgga 22380
tgccttatat aaattgtctc atttaagtct tacatcatcc ttgtgaattt tgattcccat 22440
tttacatatg agaaatcaga gactgtgaga ggtgaggtat cctggcaagg tggtagcaca 22500
gctagtgggt ggcaaagcct gaaactgaac cttagcagtt tgacttcaag cctgcgttct 22560
taacctttat gattatcttt gcatattttt tttaaatcaa gaggtaagtt tgtttaatca 22620
gagcacaaat tttattatct tggaaaaatt attcatttct ttgtcttagc ttttattcat 22680
tcttcacata gtgtattatg aagtcaaaat catatgtagt gatgactttt taaattaaat 22740
tatctattta ggtcttccaa aaatacagaa aacattagtg aagcatttta agtttttgtt 22800
ttgttttgtt tttgttttga gacggagtct cgctctgtca ccaggctgga gtgcagtggg 22860
gctatctcag ctcactgaaa cctccacctc ctgggttcaa gtgattctcc tgcctcagcc 22920
tccctagtag ctgggattac aggcatgcat caccgcaccc agataatttt tgtgttttta 22980
gtagagatgg ggtttcacca tgttggctag gatggtcttg atctcctgac cttgtgatcc 23040
gcctgcctca gcctcccaaa gtgctgggat tacaggcgtg agccaccatg ctctgccatg 23100
atttttttgt ttttatatga agttcttcta aaataaagca agttataaac acaaatacat 23160
ttaaatttca gtgtttttac aaggccaggg aagagacgcg gcttcaggga aaaatatggt 23220
tgaactttgt taatacatac atttttttgc cagcaaaatt ggagatatgc ttggtgtgca 23280
catacattaa aagcagtaat tgttaacact tttggagtac ttcacagagt gcctgcccag 23340
actgtctgac atgcttctca tttggtgcct acgcagcctt gcacagtagt aaggggagag 23400
tgaacactca tgacctcctg ctgtctatgc acacactccc tcccccacag tgcctcagct 23460
cacacctgag tatctctctg catgctccca gggagcttcc tgcagtacct taggcattct 23520
gaaacgtgtg tctttacaac aagacacact tgttaaagct gtttacaaat gagccttggc 23580
gggggcgggg aaagctggtt ttcatttcca gttattttaa atttaggctt atttcacact 23640
tcagcattct tttaattaat gtgttttaat taaaagaatt aattattctt ggttggtaat 23700
gccctttaat ttgagtaaag atgatatcta aggccagcat ctagtattaa gttatgccta 23760
gatggacttc tgttcattta ttctgttact ggtggttgtt ctttactagt gaaataagtt 23820
aacgaatgcc tgcctgtcac atgtggggcc tttattttgt gttcagcagg caccttcttt 23880
gataattata agagcttagt gactgagaga attcagtaat cttcctgacc cctatgcctt 23940
cccaacaaag gagattatct tttagtttat agaaaggtca ctcaggtaaa actgaaatct 24000
ccttcaaggc aagataaata tctttatcct taactgtgtc tctgacatgc cattattttt 24060
tcttcagtag tagtttgctg gcccataagt cttttatgtg aactgcttat ggttggaaac 24120
ttaaacactg tcactttagc tcagcacttg tttattgaca tactttccta tgtgtatgta 24180
ctgtgctagg aactgagtga gccctaggta aatgctggag ccaggggaga taaaaagaga 24240
gtttaattct tgtgttctct agctagttat tgattacttg tagctaattt cataagaaac 24300
tcttggagga aactgaagag tagttgtagg ttctacctgg atgtgacagg attctatgtg 24360
tatgcctgga tatgaggaca gcttgttgaa tactgcctgt taatttgctt ttgggtggat 24420
catgaggtca ggagttcgag accagcctgg ccaacatggt aaaaccccgt ctgtactgta 24480
caaaaaatta gctgggcatg gtggcaggtg cctgtaatcc cagctactcg ggaagctgag 24540
gcaggataat cacttgaacc cgagaggcgg atgttgcagt gagctgagat gatgccactg 24600
cactccagcc tgggcaacag agcaagactc catctcaaaa caaagaaaga aaaaagatga 24660
gagaaatatt gttgtgcttt aagaaagcct tttaaattaa aatgtgagtt gacaccccag 24720
ccagaataag ggtgatggtg tcaggctcct gaaaatgatt ttgttgtgta tattttactt 24780
atatacagct tttaagagaa taacttgtat aaaataagat acttaatttt agatattatt 24840
ataataagtc ttaacaagta ataagatata aaattaagta tcttatttta tacaagttaa 24900
ttacttatta gtggtaattc cacctgcagg cttgaagttt catggcctcc agtgtttctc 24960
tccaatggaa cctttgctcc gttgaacctt ggatggctta gaatctggca cagatgctaa 25020
gggttgagaa gtgaatgata gttctgttgg caatcttaat tccttgatgg gcaggcccag 25080
gatcacatcc ataccttaga aagggtagca gggaaatact agctcagctt cctccctgaa 25140
gaatgccagt atttcctgga aaagagctga agaggatcct atggaggagc ctgagaccac 25200
tgcaggttag gagacaggaa ggcagggaag aggagacagg aaggcaggga agaggagaca 25260
aggaggcagg gaagagttga caggaaggca gggaagagga gacaggaagg cagggaagag 25320
gagacaagga ggcagggaag agttgacagg aaggcaggga agaggagaca ggaaggcagg 25380
gaagaggaga caggaaggta ggaagaggac tttttccaag gagccagtgg tccgcagtag 25440
ggatgctgct ggttgagggc tacagaggac gtgggttaat ggagtgatgg gagtgggacg 25500
tactttactg agggatgaag gagaggtgcg gaatcttagg ctactctgga gaaacctgga 25560
gaaggaggga gatgggagag aaatagaagc tagaatgttt gcaaagatga agcattttgg 25620
ggtttggtgg ttttttgttt taagataaaa agggggggaa ttttacaagc tgaagagatg 25680
gcacagagag gaaaaagttt tatttgtggt taaagtagtg agcatgcttt tctgaaatgt 25740
catttctcaa ggagatggcg gcttggaggg ggtcaattga tggttaatag gaagccagtc 25800
taatgaaaag ctagctatac ctttgaaata ggaaatttgt agttagaaat gtttgtgttc 25860
tctttgttta aattgtagct tgtggtataa caaaacattc actcatcaaa ttttgtaaag 25920
aattggctgt atgcagatac taggaagatg gcagtaatga aacagacaca aatccctgct 25980
ctcagagaga taatattcta acaaaaacgt gtttgtaagt gtgcgcagaa cccatttcat 26040
gatttctgct tggtttgtgg actcgactga ggttgatgtg agcagttcct gtaaaggacc 26100
atccctatcc caggttgttc agagaattgt tttccgtcca agccctctga gtggctcttg 26160
tgtttgtcta ccctcttcct aattgtcgct tttaaatacc tcatagaaat actctctctc 26220
catatttcaa cttggtcagc atgtgtacct gactacagcc agtcaaattt tggtgctggt 26280
gacatgggtg tggcagtgca cgtgggaagg taattcagga attacctttt ttttggtaat 26340
aatgtcagag tgttaaagtg attagttttt agagagttaa tttcggacct atttagaaat 26400
acccatatag atattactta ttctcttgca tactgatagg ctttcttgga tggggaaagt 26460
ggtagagatg tgattaacgc tttgggcatt tgtgcggttt atcttgtctc tgcttcgggt 26520
cgggagtgac ttgttactgt ttacatgagg ctagttgtgt ggcactccct aaacagttta 26580
ttgaagtttt gtcttgtgta tgtgactgtc atattatgat ggcagagttg ttgagaacag 26640
ctgcttcagc ctattgtcaa acattttggc cctatccatc cagcatactt cttttagggg 26700
actgaaggaa agggacccag gagtgtctgt gcagactgtc atcctagtaa tgcttacttg 26760
gaacagtgaa cacaatcgat tcaagtctca agtcttttga tttaccttaa tccatttgaa 26820
ttttgtattt tagccacctt tgtatctttg acataaaacc atcacagggt actcctctca 26880
gaaatcttgg aataaaattg acactctaga aaacagatgc tccatttttt atgcttatgc 26940
tgtggtttta aatgtatcct gccagcagta tccccccacc ttaagctagg agaatctagg 27000
tgtgagaaat ttggattcgg aattccagca ctgcccccca gacatgccca ttcactgacc 27060
ccctgagcta gttccctttc ttcctcttgg gttgcttccc taataggatg cacttcatgg 27120
cttttgcatc tcccctccca gccacaagat ctttgaatct ctgagggttt tcttcaaggc 27180
attttattcc tacttaccac aggaaaaatt aacagccatt aacaaaatta tagacatggg 27240
taagttccta agttaggttt tcactgaaat atatatgagt ctagactcat ggttcttagc 27300
ttctttactg accatctctt agtcttttcc tggggttgaa agctgtcatt tttcccaaga 27360
gtggtgtggg agctcttccc tctttctgca gtgccccagg actaacagtg gatacttggc 27420
atacacaaag gcctcagtga agcttattta catcttggag atctttctgg cgtagaagtt 27480
catattggaa aggcattgct tcctcacagc ttcctatgta caaatactgg gcatttggga 27540
gtctggatga aagatgagta agacaaaggc tttgttctca agtaaaagtc caaggggaaa 27600
agattaatcc attattttat taagtacata tttattgact accacccttg tgccaggctt 27660
tctgctgggg caggagacat aagcttgaga cccatttccg tcctcacgga tctcaaagtc 27720
aagagtggga aacagataag aggccattat agcagtgctc tttgctgagt gaggactgag 27780
gaagatttct tcacactgag ttttagggga cgtggccagt gggggaggct gaaggcagca 27840
cctgggatgg tttctccaag gggaccctag agcttcagtt aatgaggtga accctacaga 27900
gtactgacac caggaaatat gcctaaggaa aactagataa actagggttt tatttttatt 27960
ttttgcttct tctgtatgct aggcaaactc acattttatt agctgtcagt ctgttttcat 28020
ttttcagttt aaaagttttc aggttgataa ctttggtccg gtatcagtca gagtgatgat 28080
gaattgagtc aaagctgttg ttttaaaaag aatattcata tgcatgccta tgaaaaagag 28140
ctgtcttgtt ttaaaatgga gtaatacaat ttgtgttaca agtacagttc tttgccccat 28200
ttccattcaa attgtcattt atatctgaaa tcattaaaat tagaaaacag ttatgatgaa 28260
tgtcttttga agcatatagc aggaaaagtc ataagtcaaa acctgccagt ttaaagtaaa 28320
tgcaattatt tggttctatg aaattgtagc ttttgctata gtgaaaagaa attggcatat 28380
ttatgaacaa ctccaggatc tcattgaaat gaggaagaca ttatttagga agacagtaat 28440
gattcagact atatttagga caggatgtta gagttaatgt gccttctctt tcaagtgatt 28500
agtgggcaga tgacatcttt ggtattaatg attgcctgag ttaacatttt taaggaaaga 28560
gtgccaccta ctgaatgaag agcttttgtt ttcttccatt caattcgaag aatcttgttt 28620
cactttgaat ccttagtggg tggcatttgc tgggcagtga tcccgtcttc cagtggattg 28680
actagggtag ctaggattct tagagggagt ttatgccccc aaaaccaggt gtagaaacaa 28740
aacctaagca taaacatgat tcagcacttg gcaagtctca aaaccttacc atcatgttaa 28800
tgtactcact ggcccagaag gttttttgtt ttgttttgtt ttgagctagg agcaaatggc 28860
tgggaggaaa tgaactattc caaaaaataa ttgaagggga ttgaagagca tatgacattg 28920
gtcgagatct tctggggaga cttcgttttc ctagggaata atattagtgc agagattgct 28980
tgatcacaac ttggccatag gtcagtggag ggattcctga ggtcaagttg cgaatccaaa 29040
ggcctacttc agagtaatcc atatggtgct ctttttgtag ttcctaacaa tagtatctca 29100
ttagtgaaag gttgagtaca tgaacagcag caaacacacc agtatccgaa ttaaaggaca 29160
tcatttgaga atttcgcata gtcattattt ttagtatatt gggacatttt tgatgttgtg 29220
gcttaattga ctactaggca tcagccatct ccagcttttt ccacttgtcg attggattat 29280
gcaagtcatg agtggtattt aaaagaggtg gactgtatgc taaattgatt tatccttgct 29340
tatgtgtaca gattaatggt ataatccatg aggggtgata gattaagatc ctgaagtgaa 29400
aaaatacata tatagtgtca ggtatattaa ccaatggtta gttgcctttt atttttccag 29460
tgtaaagtat agcagatcct tcaataatgt catttagttg aacattttgg acaattttgc 29520
taaaaagttg atgaggataa aaatctcttc tggcagaggc tactgtctgt atggagtttg 29580
catactcccc ccatctctgg gtggattttc tctcagtact ctggtttccc cctgacaccc 29640
caaagatgtg cacgttaggt tcattgtcat gtctgcaagg acccagactg agagaatgtg 29700
ggtgtttgtt aatgcaccct gcaacgggat gacatcctac ccagggctag ttcaagtctg 29760
gcaccctgaa ttgttgggac aggctctggc cacctgtgac cctgaactgg aataagtggg 29820
taaataatca tcttattaat gtttcttaaa tgtatgttac agctcacatt ttttcagtgt 29880
ttagtgttag aagtgtttgg ggtctctaga agtttggtga tgtttttgtg accagaaata 29940
tgccatagaa actttcccac ttgtttacat caattggcct atggtaaagt tggttttaaa 30000
gtcaaagttt ctcttattgt gtaacttgcc attgacatct actcatgtta cttaaataag 30060
cgttttgttt gtttgtttgt tttttgtttt tttgagatgg agccttgctc tgtcacccag 30120
gccggagtac agtgccctga tctcggctca ctgcaacctc cgcctcccaa gttcaaacga 30180
ttctcctgcc tcagcctccc agttagccgg gattacaggc acatgccacc acacctggct 30240
aatttttgta tttttagtag aggcagggtt tcaccatgtt ggccaggctg gtcttgaact 30300
ccagacttga ggtgttctac ccgcctcggc ctcctaaagt gctgggatta caggcatgag 30360
ccactgcgtc cagccaaata atgagtatta attggctgaa tagcaagtat tctctgaaaa 30420
cattatttaa taatacaaaa cttgtaaata ttttagcaat aactgtgttt tcagatttgc 30480
actcagaaaa ctagtatgac ttttaatatt gtatcccagc ttttctcctt ttaaaaaaca 30540
gaaaacccta acttctgtaa cttgactgag attaagcgta tctgatacca ttattccaga 30600
ttatgagaaa agtcagctgt gtggctacag agagctctgg cctgaagtag ttattaatag 30660
aattcacatt gggacgtaaa aacaactgga actgaaactt ggtctgagag ccgccatgtt 30720
tcatgtctca tttcaggcta ctactttgca tctttttgac ttacagcact taaatatgca 30780
aatgcaaaat tgttaaggtt tttttttttt ttttttaaag atggagtctt gttctgtctg 30840
tcacccaggc tggagtgcag tggcacgttc tcagctcact gtaacctccg cttcccgagt 30900
tcaagcgatt ctcctgcctc agcctcctga gtagctggga ttacaggcat gcaccaccac 30960
gcccagctaa tttgtgtgtg tgtttagtag agatggggtt ttgccatatt ggctgggcaa 31020
ggtgtttcac acctgtaatc ccagcccttt gggaggccaa ggcaggcaga tcatctgagg 31080
tcaaaattgt taagcctttt aaggaagaga aatgtatggc ttattgattt aaaaaaaaaa 31140
aaaactagac aggttaatat ttttcatgta aaacgatctt aaaatctttg tgctctctac 31200
tttctcgaat gttctgcttg acagttgtct gaactttctg agagctttga tagagtctta 31260
tacataatac gtgcctctct tagtaataaa gtttgaattg ctatgatagt gaatattgga 31320
ggagtctaaa agttcgtaac agtatgtcac ccatactgat atactgcctg agttagtaca 31380
aggggtctgc agatccactt agctaccacg tagatggtga tgatacctta agaaaggatt 31440
ttcacattca aaaacatgga gagccactgg attatagaat gacaaagaat attttactca 31500
aaaaaatttt gggaagtact ctccagattt aacgattaaa aggaatttgt ggtcctattg 31560
agctttctat cttctgatgg tgtctatctg cctgacagga ataatattga tgtggcagtg 31620
gcgataaatg aattgtatgt tcacactgaa tgaccctaag ctatcatctt gtagtctgat 31680
gtgatttcat aggttcttaa gttccaaaaa ggttgtgaat ttcttaagag catgtcatgg 31740
ctaatggcac agtcaggact tgattatgaa tttccagacc cctgaatcct gtcattttcc 31800
tttagttccg tgaagcttcc cacagtgtgg agtagtagtt cagtggtgca tgtttatttt 31860
taaggaaata tttcaagcat acagaaagat acagatggaa tacattagat aatagtataa 31920
taaacagcca gaaaaccttc acctgtattt aataaatgtt aatattttat tgtacttgct 31980
gcagtgcagt tggatgtgta ttttttaaag gaactaatat taaacagttg aagcctcctt 32040
tgtcttctgg ctagagcttc ttctctccct caataccagc agaagcagcc ttgtacagca 32100
gtcttcatat tctagatgtt gctagtcaac attgttacct tctgaaacca gaaaaaaagt 32160
tttattttgc tactgtcatc tgtttttcaa ataacttgtt aaaagaagtt ataataacag 32220
catagtggag gaggacagga ctttaaagtc gtagagagct ggttttgaaa ctcagaattg 32280
tcactgacta tggagagtta atcaaactac ttaatctttc tgcaggtttc ttcatctgcc 32340
caatgaagat gaggactctt accttgtagc tttggtgaga tgtaaagcca ctgtatggac 32400
aatacctaga gtagtactta gaacagagga ggcactgcag aggctagctt taatagtagt 32460
agtagtgata gtagtaattc agtttattgt gggctaccat gcacttggtg ccattgcaag 32520
tacttcatcc atgttcattt aaaaagtgag gtaagaatta actatatgta aaagacttag 32580
aacaaggtgt ggcgggtagt aggtgggtca taagtattag ctattattat tatccccatt 32640
tataggagaa taatgggagg aactctaaga agttaacttt cttctaagta ctttacatat 32700
atattaattt atttaatcct ggtcgctact ttatatggta gatactatta tccccatttt 32760
atagtgagga aattgaggca caaagaagca cttctaccaa gattgcacag gtagtgtcag 32820
agcttatatc ttaacccagg cagtctcgct ccagaactca tgcccctgat cgctgtgcca 32880
tacttcttct gtatgtggta tggcttctta ccttatctat ccagtcctag gaacatatct 32940
ttcaggtggt atgatctcta ttgactaaga agtccttcct ggttttgttg tagatgcaac 33000
acgtttcctc atgtgacccc agcctgttaa aatggggtca ttttgataga agctacctgg 33060
atttgattcg tttgggtggc tgttgctcca taagtacctt taacagtctc ttcacccccc 33120
acccaccagt tcttcctgaa gtccccagtg tgggtcttac atgtgctgaa tttggccagt 33180
gacccagtag ccgtctctgg tcagcactgc tttctggcca ttgccatcac ctccttcagc 33240
cacattggcc tcgccccctc ggacctgctt cacccaccag tcctgccagt aacaccacca 33300
tcagtgctga agatgcacaa tgttcccact gtgcagagtt ccagggtctt tacaatgaaa 33360
tgagaaccat tccccaggcc catttatttt attttgtatt ctgggactta cttgtaacca 33420
tatagagacc tttagagaaa ataaattacc aaggtttttt ggtttggttt ggtttggttt 33480
ctcatggctt ttttgctttc accccagacc taagagcttg gcagagaatg agtggactgg 33540
accaggggca aatctttgtg acagactctg gcctctgcta gtggttggat tgggccaggc 33600
ttgaatttct gatgccccct tctcttaggg tgggttcata caacgagact acccatctcg 33660
ctggctgtct aaataatctt ttctccccat attcattttg aattattgga gccttaattg 33720
cactacagac atgctaaatt ttgtgatagc ttaagtagta ttaagacatt aagattcctg 33780
gtgttagttt tttctctgca attttcttag aaatattgac ttactggagc cagagggtct 33840
gtagagatga gccagtacag gtttcttaga gtatgttcca aggaacactg cgctatcaaa 33900
gatgctctgc ataaaaggac ttccatggca agtgaatgtg aggaatgcta cataccttct 33960
ttttcccctt ggagattaat gacacatgta ggtcttatta gaggctctgt gctgtcctgt 34020
gataaataaa gccaactaac ttgtttttat caagtgttcc ctgatttgca gaatcattag 34080
atgtttagta ttataggatt gttttttttg gttttttttt tttttttttt tttttgagac 34140
agagtctcgc tctgtcgccc aggctggagg gatctcagct cactgcaagc tccgcctcct 34200
gggttcatgc cattctccag cctcagcctc ccgagtagct gggactacag gtgcccgcca 34260
ccatgcccgg ctattttttt gtatttttag tagagacggg gtttcaccgt gttagccagg 34320
atggtctcga tctcctgacc tcgtgatccg cccgccttgg cctcccaaag tgctgggatt 34380
acaggtgtga gccaccgtgc ccggcctagg atattatttt gccaaagcta tgtcttctgt 34440
ttggaacatc ttttggcctt caccaactct ctcttccagt tctgttcttt aaaattattc 34500
aggcatcacc tcctctgtgg atcttttcag gactctccta gataaaatta aggatggaga 34560
tcactccacc ttcgcaactg tttatgggat gttaaatact tttattacag cagagttgac 34620
attgtgtttt cttgcttctg tgagacagaa tgattggagg aacacagacc ctgttttatt 34680
tatctttcgt tttttaattt ttcttctttg ctgcctggcc agtgcttatc tgtggtaggt 34740
gtgccagcat tcattgaacg gagtggtttg ctagcattca aagcataaag aagaaaagct 34800
gcatttgtca ggaagtcatt cttcctcatt ctgagcatcc cagttaacat gcctttttac 34860
caggtggaag gaaatagtat agtactagct gttctgtaga attttgaaag aaatccttct 34920
cctagcaaag actgtaagag ggctttgtat gctaattcgg ggttatcccc tcttctcctt 34980
taatctcaga gcattaaaaa cagttaaggg cttttttaaa atagaaggta ttcactcaaa 35040
atattacata tctataactt cttaaaatac agaagcttta aattttgtta gtggggtaag 35100
aattatagta agttgtatta tgccataacc tacatatact aacagaccac tttcgtaagt 35160
atgtactagc cctgttgagt tgaccactta gaagtatact caaactgcac tgccacattt 35220
ccccaaaggt aacaagtaaa cataggagaa aacatacact gcagccttca tgtaacactg 35280
acttgggatc tttttaatga acacccaaat ggtgaaggaa cagaggtttt catttcactg 35340
tgccatgcat tctgtaccag tgcccccaga taagggcagg atgcatggcc ttgctgagaa 35400
cacccctccc cccacagtag tagtgtagga agttccaacc tacttctcta gtgtaacgtc 35460
tctctaggtt tatgcatcag ttgtcttgta gacattccca gccctagatt tgtcaagtag 35520
caagggggga ttcttaaaag gaaaaacacg tttagccaaa aactgttttg ttttgttttt 35580
aaaaacatcc ttcttactta ctgatctgtg ttcaacaatt agggaagagg atactcacaa 35640
tgtttcattt ttccccaaag gtttctaaag gtttttcctc aagtaccaag gacacaacaa 35700
aggaaagaat aaacagtgga atttttagcg cagaatgtca aaagaataca aggttttatg 35760
ggtttttgtt ggaaaggaac aagtgggaaa tgggaccata ttaattttaa actccctctg 35820
ttgggtgctc agaacatagt ttaccttaag cctgatggat gttctgagtt tctccccgca 35880
gggagatagg tgaaagagtc ctagtattta gaagtactgt tacaaagctg attactctga 35940
tgagtgatat aagtgtttta aagcaatatt tagtctaagt agtaaatatt cctaagacag 36000
acagtaactt tacaattcat ttgttttgtt gtcttaaatg gcagaacaat gttgtttttc 36060
tgtcactaac gtttttatat gttttctaag atgatgaatc atacagaatc accaaactca 36120
tatttctgtt caggtctgac catttttaca attttcattt gcctatgtaa atattaccca 36180
catattatag ttcataattt gtgatatgtc agcagatttc attgaacttg agtcttaggt 36240
cacaatagaa ctaacaacat attggcttca ttctagtcca atttgttttc ttttatgcct 36300
acacaccaag ggtgttcgct tgaaaacaag tcttccttca cctcctgctt tttctcctca 36360
cctgctcttt aaaaaataat tgtacctgac tcaaattgat agtcttctag gattttcatt 36420
cgctaactca aattgctagt cttctagagt tttcatttgc taccaagtta acttgcttac 36480
taacttgatt tgtcttatct cttttagatt tatttaaaat ccctaccaat tttaagagtc 36540
actgcatatt cttgattact tctgcatggc tatatctcca tgtccccctc tccgaattct 36600
gatgtgtatt tgacttgttt ggattatatt tcctcctggc aagttttgac ttcgttgcag 36660
tttgacgttt tcttgacctg tcagtgctca tgattgtttc cgtggcttaa caaagtgtac 36720
atatttagtt tcattattgt ataaatttgt tgatttttct gttcatctat taacacattt 36780
agaagaaaga acttttcttt ttccaaattt gaacagaaca tctcaattct attagtgatg 36840
tgcttagtaa tgtgtattgg attgatttat tgtggtacat taataacttg aatgtggtag 36900
tttttaatgg aatctgccag ctacatttct gagagacatg agtgtgccaa agaaacacca 36960
taaccaagct tttacactac tgccttattt tctttctgga actaggcagg tgtaaagaga 37020
tgatttagaa aacctttttg cattttatct ttttcttagt gtttatctgg gtttcagctg 37080
caaggaatat agcccctttc gtttgatgat gtttatccat atttaaacat ggccacctga 37140
aagtttagcc ttagtgtttt atcttaaata tgtcagtgac tttggagact gttgaagtac 37200
atccataatg tttgtatgtt agtttaaaag taaaaaagac ttggtcgggc gtggtggctc 37260
atgcctgtaa tcccagtact tcgggaggcc gaagtgggtg gatcacttga ggtcaggagt 37320
ttgagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 37380
tgggcgttgt gttgggcgtc tgtaatccca gctactaggg aggcgaggct gcagaattgc 37440
ttgaacctgg gaggtggagg ctgcagtgag ctgagatcct gccactgtac tccagcctgg 37500
gtgacagagt aacactggat ctcaacaaaa aaagtaacac ttttcctgca aggcagtttt 37560
ctcaaattca tatttgaata ttcttatgac tatttgtggt caagaaagat gccttttaat 37620
cataaaataa tcttgaatag agtttttaaa aaatgtactt catgcaagaa gacaaatgag 37680
aatcttttcc ttcacttaat aatgtattct ctgctcataa taatgccctg gtctacagtt 37740
gtcagtattt tatgcagacg ttattttata tgttccagtg gtgtctgaaa tttatagcac 37800
actgagtttg agttaccagt aataatttac ttagaaatcc cttcaagttt attcagtatt 37860
caatagagga tcagttgctt taaatatatt catacatttt gagcatgtaa gaacatttag 37920
tataggagaa ctgtacagtt aatatacatt tttctttttg attcactttt cttctctaaa 37980
gggagatttg ggcatgtact ttatagactg agtcaaaggt aattgactgc aaaaaaaaaa 38040
ttgatacaga gttgccactt ttaagaatga tttgatactg actagtagct ctctgtcttt 38100
tgtaaattcc ctcttattat agttagttgc ctgatgattg ttacaaattt actaatttgg 38160
aagtaataaa aactttcgaa tattcttcct tttctcattg aagttcttta ccttttctct 38220
ttgaagttac ttacatatcc ctagaggcac tagtttatgg tagaagttgt taagggctat 38280
gtttgtccat catgaatgat ggtgtaacat ctgcatggtg ttacttctta gatctttgtt 38340
gattagaagt gataatcagc tactctgact ctgaatcagg gagtgtttat caagcccatg 38400
acatctgttg ttctgggtgc tttgttccta gctgcaggac aaggaaaagg ccctgccctc 38460
aaagaattta ccctttcctt gtctagttca gccagtgatt gtgtgtttac agtatgatta 38520
tctattaata cattgtctta ttttaatttt ggttaatttt atatatattt tatgtttcta 38580
tactgtgttc tggttttcaa aatcctgtaa ttgtgctgga gaatactttt aattttaaaa 38640
ctcaaatgga gtggtgtttt gatggaaact aatccatgat ttagggtaaa tggagttatt 38700
gtgcatgacc atgtggaata tgttatcaat atgagtcaat cagaatcact aaggtggtat 38760
taaactgctt atatgtcttg tttataatta gttgtgttat tgtctttgtt acttgacttc 38820
catattactt aactgttgat gtggttaatc agaacatgag ctttttgagg gtgaattcta 38880
tgcccatatc tctcaaaggc ctaaatagga atgtttgcac acaatactta aaatagtttt 38940
tccactaata aagatttctg atacagattc aacatactat aaaactgatt tcaaccgggt 39000
gcagtggctc atgcctgtaa ttctagcact ttgggaggcc agggcgggca gagtgctttg 39060
agctcaggag ttcaaggcca gcccggacaa catggagaaa ccccatctgt acaaaaagta 39120
caaaaaaatg agtcaggtat ggtggcttgt gcctgtggtc ccagctactc gggaggctga 39180
cgctggagga ttgcttgaat tgggaagtgg aggttgcagt gagccaagat tgcgccactg 39240
cactccagcc tgggcgtcag agccaaaccc tctctgtctt taaaaaaaaa aaaaaaaaga 39300
atcaatcctt tgttgtgcta aagagaggat atttacccta tggggggata aaagtagtag 39360
tgcctgtttc ttgttataaa taaatagcag ttgtgccgtc tttagtcctc agggtcaaac 39420
tttactgaat aaaatctgga ataaaatctt gtgggaacta attttcagaa tgtgagccat 39480
ttttatacat tgttacttct tatgtaaacc tacctatgtt ataaatgttg tatcatataa 39540
agatggaaga ttcgcccttc caatggttta tttaatcttc cttgcttaga aggaataggc 39600
caacagttgg caaagacagt atgtctctgg agaaactatc ttactggaaa atagaattgt 39660
cctagtattg agataaagat ggtttggttt tggttttggt tttgtttgca gatgcctcag 39720
atctaggtca acagattaaa agtacttgta aatattcatt ttccttttgt tcttggaaga 39780
cacagactgt gaaatcactc tcatctgagt gtaagtcata gtgtttttta catatagact 39840
ttatcacctt gaacatgtaa ctgaacctcc catatccttt gtctcatctg taaaatggag 39900
tagtaagagc cgcgtctcaa gagaattgac tgagtaaccc atgtgactgt tagccctatc 39960
cttgggaagg aattgtcagc ctttctgttt cattatgctc tccctatcct cagtttaagt 40020
cattcctgct cttgtccttt acctggaacc ttacacttta agtgtcccac aatggactag 40080
gattgttttg gaaggtcgtt cctcccttgc tgtcctcttc ctcagtaata tggcttatga 40140
gtttggtagt gtgtgaattt cttctgctag gaaggcttca caggtggacc ttaattagtt 40200
agctctgaat tgtgcctatc ccaaataatg tattttctag ggttccttga agttccttgg 40260
acaccaagag aatcaagata cggaaatctt aatttatacc taaggttaaa tctcattaat 40320
ttccagaaag gttttctacg atcgttatag tcttagttgc ctctattgca gtgaaatgct 40380
ctaataatga agagaattaa tatgcttctt taattattat aattaatcaa atcgtcactg 40440
ttgtaaaaac ttacaaaact tgtttggatt attatcaaat aggtatcagc acaggtgctg 40500
acttcttgta aaaacaaact tagactgggc agtgaacact catagcagca gagagtacag 40560
ctcttgaatc aaacctgtgg gggtttgaat ctggccctgc cactcactta caaactgtgt 40620
taccctgggc ataacccagc ctccccaagc ctccgatgga aaagacctca cagggttgct 40680
ggaagggtgc agtaaattca tacatgtaaa gcacctaatc cattgtctgg catgtaatat 40740
aatttttctg tgatgacact ctggcagtta tttctccata tcgctggttg ttgacaaaca 40800
taatatttcc ttcctaagga tgagccattt aataaataac ttaaaaatta cagtagactg 40860
gtaggattct ttttgtttgt ttattttttt ggacatggag ttttgctctt gttgcccagg 40920
ctggagtgca atggcgcaat ctcagctcac cgcaacctca gcctcctggg ttcaagtgat 40980
tctcctgcct caacttccct actagctggg attacaggca tgcgccacta tgcccggcta 41040
attttgtatt tttagtagag atggggtttc tccatgttgg tcaggctggt ctcgaactcc 41100
caacctcagt tgatctgcct gcctcggcct ctcaaagtgc tgggattaca ggcatgagcc 41160
accgtgcccg gccaggattc tatttttgag tgtttatgaa atgtcccctg tgtgccaggc 41220
attgtgcaga actagtgttt tagtcagact atttgaggtt gcagggaaca gagatgggtt 41280
aaaatttatt tcattccaaa ttaaagaatc caccaagaag tttcctccat tgcagcatgt 41340
acacttggcc cgtggagaac tagtcattca ttatccaggg gtggtataaa agtggctgtc 41400
atcatctaac agcttatcag gggacccgtg tacaacttgt taggttgact tttgttgctt 41460
ctgcatccct gtctttcttc taatttctct ctcttctccc ttatttctgt ctcagtgttt 41520
ctacttatta ccttgctctg tttccgtgtt aagtgccact cttcctgcag taacactatt 41580
tgtgtgtttt actttcaaac tctcagggag agagctgact caggcgtaca ataccgttca 41640
gtacagaagg tcattggacc aaggaacatt cctggaccag gcagctgtgg aagctgggat 41700
ggattcagat gtataaagca ccttaagcat tagccaccac ccttaggact gggcagaccc 41760
ttcgcttccc agaaaggggc agtatgtcag gtcactgggc agtgtgatag aacaatgaat 41820
aagagggaac ttgtcctgga agagctcaca atgtggagag ggaagcagat acttaaacat 41880
atacttaatt ttatgatata ttgtagttaa tatttaccat gcagcgggag agcagctaac 41940
tgccgtagaa tggtggtagg aaattcttca ttgaagccat attgagatgg caaagggtat 42000
tcctggcagg gaaaaaaaaa aaaaagtcat ctgcagagac gggagtaaaa tatcatggta 42060
tatttatgaa gtttttttgt gctatgagaa gagggccata gttggtattt aaggggctcc 42120
aggaagaagg tctaatttat ggtactgatg aagatgatta gacatagaac caggagaaaa 42180
agacctcata gaagagtaga ggagagacct acaagagagt tagcacaatc aacagtggct 42240
gacaccacat tataagggga ggactgacta cagtttccct gagaagggac ccttgaagca 42300
tcttggtttt taacaggtga gttttgtagg tctaggaaga gtctagcact agaaacctaa 42360
cctcagggag taagcgttct tgaagttctg tgtcaggtca caaattcatt cttaggaatg 42420
tctagaaacc aaaaccaaga aacctcatgt ttcctaaata aacaggaaat gaagataaag 42480
cttgatctgt aatagtgctt aagtttctct tatttttctg accacaattt tatttatttt 42540
taagtcttca aggtagtttc tcaaaacaca ttgtttagct gaaatctgtt atttttttaa 42600
ggtcaaaagt gtatacacta ttatttaaaa taggtatgtt tctgggtaat gtttggcaaa 42660
aataactccc cgaaacattc acgtttaacc aacatgagtt ggagatggct ctcatctccc 42720
agtgacttca cagctatctg tttagattag ctttggttaa aaaaagattt ttttcctgct 42780
atggctgtga tatcttaatt ggatgataaa tcactgctat atacatacat acatacacac 42840
acacactcat ctagtaaaaa tgaaaaccct atatatgcct ggcttatgga agattatatg 42900
ttaggattat aacaaaaaca atacaagtat gtaaaaaaat ttttcacagt ttggttctgt 42960
ttcagagaga aattaaacag agtagatgtg atttattcgt ggcaaataca ataggattta 43020
ctatatattt cattgattca aagatcccag tggttgtaag ttgtaccatt attttatata 43080
ctatgaagga aataacacct gccagttaaa ttataataac ttttgattgc aagaggcatt 43140
catatttcag atattaaaat gtgaaaaaat acacatttta aaattaatga catgtaatta 43200
ttacaaagag actaggaaaa acactttggt ttatatttgc agattaattt aggaacagtg 43260
aaaattgttc tgaacaacat ctaaattgca aatttagtct taattaaata cagaattata 43320
aaaaaagtta ataagaatag tcattaaaat ttaaaactgg gaaggctgta ggactgccag 43380
agttaataag tgatcattca cttaatatat gttcatactt attatgagcc agacatgctt 43440
agatgttagg tgtatagatg gcgataacac gtggtcccct cactcatgga gcttacagtt 43500
cataagagag gaacagtttg caaactgcat taaccatgtt aaaggaaaaa tacaagtgct 43560
gtgaaagaat ggaactggga gttcttaatt gaaattggga aagtctctga ggagttgagg 43620
aaaatctaga gagtgggtag aaattaggta aaaagtagac agagaaggaa gcagcctgtc 43680
cagaagccct gagtaggaaa gatcttgggg ttattgaggc agtgaagaag gggggttgca 43740
ggtctgatga caggaattga ggtgagacca cgaggtgcag ggccacttag gttgggctaa 43800
acattttgga ttttagtcta agcccggggg gaaccactag agcattttaa tggaggaagt 43860
aaccctggct gcactgtgaa atctgggtaa gattcaaagt taaagaagcc tcgttaggag 43920
cctgttgcta gttcagagca ggtttaagag cagcttgacc tggatgggcg tgtgaatgga 43980
agacatattt tttagaagat tatttgacaa tattatcaaa agtcttcatt tgtgtacatt 44040
tttaacccag catttccatt tctaggtgtt tattctaaag aaataattta ggccaaatgt 44100
ggtgtaatcc cagcactttg ggaggccgag gtgggtggat cacctgaggt caggagttcg 44160
agaccagcct gaccaacatg gtgaaacctc atctctacta aaaacacaaa attagccagg 44220
cgtggtggca catgcctgta atactagcta cttggaaggc tgaggcagga gaatcacttg 44280
aacctgggag gcggaggttg ccagtgagcc tattgcacca ttgcactcca gtctgggcaa 44340
caagagctaa actccatctc aaaaaaaaaa aaaaaaaaga aagaaaaaag aaaaaaataa 44400
tctcatagtc cttaaacata aataaggtaa aacgaaattt aaaaaagaat ctcagatgtg 44460
tgtaaaagtt cagctactag aatgctcatc cctattattt atgataaaag aaattggtct 44520
aaaagatgac agtattttca aacaagtgga aaggaaagag acacattaga ctttaaggag 44580
gccatgccat ccagaaagat ttgtttagac aaggaacatc ctttgtgtgt ttgactcagg 44640
gccaggaaca gaaactgaaa atccatagca gagaagagat actcctgaaa cagatttggg 44700
ggaagagaga tagctaggac cagaggaaag actatcaagc accttggtct aggagtgcag 44760
gagtttctgg tataaaaatg cactgcagtt ccactgtgag gcttattttt tggaactagc 44820
ctgggaacca aaccacctct tgcaacattg ttactggagg gggaaagcgc ttttaatact 44880
aaagacttgg aagtgaattt ttattatgca gtcaccacat aaattcagtt gcctacaaag 44940
ctgagcctcc tggaatacca actgagcagg atggactttt ttggaagaca ctttatcccc 45000
tgtgttcttc acccctacct ctctttctct gccttcctct ccctcctcct ttttctcctc 45060
ctcctttctt ctctgccttc ttcccttctc tccatccccc cttcctcttt ccttctttct 45120
cctccctccc tctcttactt tcttctacac atcccctaat atttatattt tataatcagc 45180
ataaaaagca gccaagcaca tataagtaaa ttagataatc ctcctttttt catacttttt 45240
gaaagtctca tattgcttct atataacagt atttgtgtgt gtatgtgtgt gtaaggaaat 45300
attttacgct gtggtcttaa tgcctatttg caagtttcaa accaaatgtt atgtattctt 45360
tgtatttcta aaaatgtcta ggccagttgc tgatacaaag atgtttaata tgttgccttc 45420
tactttcctc acagtcttga tgcttcagtg aaacgggtta accgtttcct ttctagtgaa 45480
tatttttttt taagtagttt cttcttcctt tggctgattc tctgaagatc gtacttcata 45540
gttgtgatta gctggaaaat tcctagagga gtttgaattt gtctttgtag taaacttgag 45600
gttcttgttt ttggtatttc cttgagtatt tccttttcct atcagtgtag aaaaactgtt 45660
ctctagcttt aaagactttt caaaatagtt actgaaatta gcttagtatt tttaaagttg 45720
ttactaatcc caaggtgcag ttgctttaac tgcatcctta taaatcaggt tttcaaatct 45780
atgcatatcg tgtatgcatg tatgctcatg tggatatggg tatattttaa aattagtgat 45840
tttcgtgagc ttgatgcttt gcctgttagg ctttgtagag ttaattctca aacgttctta 45900
gtttagagat tgttttattc tggtaaatcc acaccatttt atggagtaaa gatcaaatgt 45960
ttgtactgga taatttttat tctttataga gtaccccaag tgctttgtta tgaagtcact 46020
gttctatgaa aataaaaatt taatcatgta ggctatgaaa aattgttttg gggtcataga 46080
tgatgtagtt aagtttcact tcacttatta aatatttatt gagcttattt cagataaatc 46140
agcatatcca ccagattcta tctgtattga cttaatttat tggaaatcct gggataaaag 46200
tgtagtaata cacccttcta aatatttgtt atttgggtgg tagaattaaa aacaatgcag 46260
tcttagtgaa tatatttgtt aatatagtgc ttaatgtctt gggattcatt ttgttaacta 46320
cagtggaaca taggtctgca tgatatatgt cagtagtata taattcagaa tcttttcaag 46380
ctttaagtca tttggggttt ttagcagtta tcttttttat tacatgtccg ttggaagtat 46440
aaaatagaac catccattct gtttgttctt ggaaattatt tttcatatat acatttctca 46500
ttttatttgt ttctgcctgc attttagtcg tgagatggag aataaagaaa ctctcaaagg 46560
gttgcacaag atggatgatc gtccagagga acgaatgatc agggagaaac tgaaggcaac 46620
ctgtatgcca gcctggaagc acgaatggtt ggaaaggaga aataggcgag ggcctgtggt 46680
aagtggctat gggttaccag ttataaggaa gaaagcatag gaggaaatgg aaaagtaagc 46740
ataaatagat cctcttgtaa gcttttcttc ttcattttaa atgtagtagt tttctttact 46800
tgatattgtg gtcatttgga agaaaccata attaaaactg tgctcattaa acaacttaaa 46860
ctattctggg aacttaactg ttgtgtttgg tggaggggta aatgcttaaa ccaagactgc 46920
cctctcatgt cagtatctaa aatcctttca ttggagtttt atactgtact tgtaaatttt 46980
aaaaagaatt tttccagttt attttagatg ttttatctct aagacaggat ccaaggatct 47040
taatttcaga aatcttctag gaaagaaaac atttaattgc agtaattcat aagtgtaatg 47100
attgggtttt cacatgcatg cataagatgt gcgtttctcc aactttgtta cagtgtcagc 47160
atgttatcct catttgacat gaaaaaatgt ttaatagacc tatggggatt aagataaatt 47220
aaaaatgtgt ggggtttgat gaaagaaaat ctagagtcct agattttaaa aagcagggat 47280
actctgtcct ttgctatagg tataagaata tatattctta taagaatacc atcatgaaat 47340
gtgtgtcttc attcttacaa aggaagaagt attacagtat cctagcacta atctctctca 47400
gcaagttttt attttgttct tttaaaacag atatggcaac ttaaaattca tctaagcttt 47460
gacaagggtc taaatacacc cctgccaagt gattgtctgc cctacattca tcccatatgc 47520
ctatttaagt ttacatttaa attaattaga tgtaaataaa agtaaaaatt tagttcctca 47580
gtctcaccaa ctacatttca aatgctcagt aaccacatgt ggccaatggc taccttttag 47640
gcagtgcagt tttagcacat tttcactgcc tcagaaagct ctcttagatg tgtagtactg 47700
actcgtgtct gacttaaata actcaataat ccctgtggct ttcgatatcc tcatcactga 47760
gctgcagtct gtcaggaata ttttacccac tggttctcat tctaaccgat ggaattatac 47820
agaataaatc taattgttcc tttccatacc agcacttggt aagttattat gggcccgtga 47880
gtccttgtct ttacagctaa gtttctacat ttcttccatt tattactcac gtgaggtggt 47940
atggtgggaa cccctcacca ttttagctat tcgtgccaga aggtgaatat gaagaaatta 48000
aggatttatc ttagagaaga gaaagtgcta ttgaaacatc ttgtagaatg ttggcagtta 48060
aaagggcata ttactactca atcaatataa agaacttttg aacaagcaga gccatctgaa 48120
gtttgaatgt gctgctttct gagctccttt agatggaggt gttcaaacag cctaaatctt 48180
ttgagaatac cgtagggcat aaatcacaac tttttaaaaa tgagccagct atttgttctt 48240
tattatacat gaactaagaa tatccagttc tctaaaacaa aattttggtt tttatactgt 48300
tcactttcta gcaagtacca aagtaccttg tctgtatata agacatgagt gaagagggag 48360
gagatgtgtg gaataagatg cataacacat agtccttaag cttaattatg ccaccctaca 48420
ttttatgatt tacggatttc gtattatcct taggaagttt actgtttact tgggaggtct 48480
gattttgttt gtttttatac tttaagtaag ttgtgtcaaa tcattcttga aacataaagg 48540
gtaaatatct ccaaatggga aaattagact tatacataat aaatagagta atacatgaaa 48600
tatcacaaag caacttgtga ctaggtgcca aatgtgtggg atgggcagaa gagcaatagg 48660
gacttaggaa agagaaggaa tgtcttgctg gtagacttca gggaagtttc ataaaaggaa 48720
gaattttaac tcagcgtaga aagatgggta aattttcctc atgtgaaggt gtactgcctg 48780
gggtgctgca ggctggagat gagtattaaa ataggaggag agtgagtgaa agcacaggag 48840
gaggaagggt caggcaagtt tggtgaacac agcaactggc tatagaacag gagcagtggg 48900
agaaagtcca gaaaggtctg ctgagcttca gttgtacaaa gctgtggagt ttggcctttg 48960
gtcatggcta gattaggtct gaaagcctta attaaaaaaa aaaaaaaaaa aaggcaggtc 49020
ttgtaaactg catttctgct tgagaaattg atctttaaac ttctagtctc ttttggtttt 49080
ctgagataca catctaacct attattgtaa tataacattg taaagaaaca cacacacaaa 49140
gcagggaaaa tgattgcata gtgatcaaac tatttgaaat tatgcccagt gttgtttcaa 49200
ggtcctacat tttgtaaaaa caaataaaaa cgtacctaga tctttgatct agtagttgaa 49260
taagttgact gtagaagtta tgagtgctta tttttcacat ttgtttaatc acctttgatt 49320
gttgcttttg agtgttaaat gagttagggt atataataac aaataatacc atttctacag 49380
ttttgtatgc attacaaaat tgtaagggag gaggttgcgt tttaactagt gttaaatcct 49440
aaatgactga aatttgtgca ggtaaaaata atcttttaca ttaatagctt aaagtaataa 49500
taaaagttga tatattgtct ggtatactgg tataatattt cataacaaaa actcattaag 49560
tgtatttcct agtctatgat atttacattt acttaccttt tatattttta agtaatcaaa 49620
atattggaat actttgattc aggtggtaaa accaatccca gttaaaggag atggatctga 49680
aatgaatcac ttagcagctg agtctccagg agaggtccag gcaagtgcgg cttcaccagc 49740
ttccaaaggc cgacgcagtc cttctcctgg caactcccca tcaggtcgca cagtgaaatc 49800
agaatctcca ggagtaagga gaaaaagagt ttccccagtg cctgtaagtt aatgttacaa 49860
caaatatgtt agtttttata atttttagct tcatttataa caaagaaaag actggccagc 49920
catctgttag aacatcagtt ttcaaaatat gatctgcaga cccctgagga tggggggggt 49980
ggttcctgag accctttctg gggtctatta ggtcaaaact aattttgtga taaaactggg 50040
atgttgtttg cctctttccc tgcattgata tttgcagtgg tgggtaaagc tactggtgcc 50100
ttttcccaat ttaaggctac aactgtagaa actatattca ttattgctat gtatcagcca 50160
ttaaagaaaa aaatgccagt tacacttgat aatgcctttg acaaggaaat ataaattaat 50220
tttattaaat cttgactctt agtaaatacg tgcctttgta atattgtgtg tgatgaaatg 50280
ggatgcatgc ataaagcact tctacatacc aaaatccagt agtttctaaa ggagaagtat 50340
ttgtgcggtt gttagagttg caagctgaac tagttatttc tttcatggaa catgaaatga 50400
gtgaccaaca aactatgatt atttagattt gggtatttgg aagacatttt tcttaaggtg 50460
aattaaatga gactgtcact tcaaggaaag caacttaagg ctgggagcgg tggctcacat 50520
ctataatccc accactttgg gagggcgaag tgggcggatc acctgaggtc aggagttcga 50580
gaccagcttg gccaacatgg tgaaacctca tctctactaa aaatacagaa attagccagg 50640
catggtggca gatgcctgta atcccagcta ctcggggggc tgaggcagga gaatcgcttg 50700
aacccaggag gcagaggttg cagtgagcct agattacacc attgcactcc agcctgggcg 50760
acaacagcga aactccatct caaaaaaaaa agaaaaaaag aaaagcaact taagtatttt 50820
ttcactagtg ttaaaagttg agatgtcgaa acaaaaatta gaattttaga aagctactat 50880
ccaccactat gagcttgaca gcctcccagt gcttagactt ttctgataag attggtgata 50940
acaaatgtga ttattttcat gctgtataat gaaatatgtg aacatttgga agatctgcgt 51000
aacttaagga accaatattt tccacgtgat cagtgtatga taataacaaa attattcata 51060
ggtaaaagat acattcaaag tgtaaaatac accatttgga tttttaatgt gccagtagga 51120
aaagtttgtt gatgtggttt cagattccac attacaactg cctttaagaa accatttttt 51180
gagctttggt atagtaccaa agaatattca tcattatttg aacaggcagt ggctcacacc 51240
tataatccta gcactttggg aggccaaggt gggcggatca ctggaggtca ggagttcaag 51300
atcagcctgg ccaacgtggt gaaaccccgt ctctactaaa aatacaaaaa ttagccaggc 51360
gtggtggcag gcacctgtaa tcccagctac tttggaggct gaggcagaga gaatggcttg 51420
aacccgggag gcagaggttg cagtgagccg agatcacgcc actgctctcc agcctgggcg 51480
acagagtgag actcctaaaa aaaaaaaaaa aaaaaaaagg ggctattaaa atactccttc 51540
cttttacatc tacgtatctg catgaggcca aactttcttt catatacttt aatcaaaaca 51600
tcatatcaca gcagattgaa tgcagaagca gctatgagaa tcttagctgt cttgtatatt 51660
aagctaaaca tcaaagaaat ttgcaaaaag ataggtggta aattcatgtg agagagagac 51720
ttctagtagt ggaaatgcat gttaagactc actttctaac tttgaagaac aaatgattga 51780
atggaaaaat ggttgagata gtgaccacaa gaggagtttg ggtttttttt taagatctgg 51840
agttattaag gtacataaat tcgttaaaaa gtacatttaa agcaaaaaca ttttacagta 51900
aaacctgatg cccaacagta gttgttggct ctatgttaaa atacctttaa attaactatt 51960
aatttttgtt aacttaaaac aataatcagt tactagctca cgaatctgca gattgggcag 52020
ggctcagcag gggtggctta tctctgttcc ttgtgacatt ctctgaagat gaaaggtcca 52080
agactgcttc ttcactcaca tgcctattgc ttcagctggg atactggaac acttgggggg 52140
ctgttggcat ctcttcctcc tagcacgaag actgggttgc aaagagtatt gtttcgagag 52200
gcaagtctca acatgcaggc tcttctcaag cctccacttc attgtgtttg ctaatgcctt 52260
attgtccaaa gctagttgca tgcccaaacc cagaattgat gtgataggga actacacaag 52320
aatgtaaata ctgggaggta tggttcatgg gggccatcaa aatgaaagtt tacaacaagt 52380
ataaacagaa ctgtcttcct tccccacacc ccacccccaa aacccacttt gggcatatat 52440
gctagacaaa gttacccctc attcttttta acagttacat agcctttcat tagctggata 52500
aatcatggtt tatttaatga atgatatact aatgaacatt tataatcttt ttaacctttt 52560
gttactgaaa acagtgcttc aaaagtattt ttatacgtat gtcatcttgt acatctgtga 52620
gcatgtatct gtgaacatat ccataggctg gatacctagc aggtcaaaat gacgtgtgca 52680
tgcataattg gctttttttg tttgttttta ctttttagta actgcttttt taaaaataat 52740
ggctttattg atgtgtaatt catctactgt acaattcacc tgtttagatt gtacaattca 52800
gtgttttata gtatattcac agggttgtgt agccattatt acggtcggtt tttaaacatc 52860
tttattaccc caataagata tcctagacct attagcagta ttaaagcaaa ataggtagta 52920
ggtagcctgg ggttgtttct acacctggaa atgaaaccaa cctttagcca atcacaaaca 52980
gccagccagc ctatttgtta tataactagg gactttgcat aatgccatgc ccaagtaagg 53040
caaacaccta gctgtagcca atcagctgat tcctttgctt tgctttgctt tgtgttcagc 53100
ctgtaaaagc tggctgttca aggtgctaga tcagagatct ctgaacttgc ggttttgagt 53160
accacttggt tcatgaatca ttctttgctc aaataaactc tgttaaattt attttgtcta 53220
aagttttcca tttaacaaca gtctctccca accctaggca accactaatc tattttctct 53280
atatatataa tttgcctatt ctggacattt catataaatg ggatcactta ataggtgatc 53340
ttttatgact ggcttctttc acttagtatc atattttcaa ggttcatcca tgctatagca 53400
tgtgttagta ctccattttt aattgcagag caatattgta tggatatacc acattttgtt 53460
tatctattag ttgatggaca tttgagctgc tcctgtttgg tggctattat gaataatgct 53520
actgtgaaca tttgtgtaca agttttcagg tggacatata ttctcatttc tcttgagttt 53580
atacctagga atggaattgc tgggtaatac gtttaacatt ttgaggaact gctatactgt 53640
tttccaaacc agctgcacat tttacattct gccagcacta tatgagaatt ctaattgctt 53700
tgtggtcttg ccaacattta ttacccttaa ctatttaatt agggatccaa aaaactggaa 53760
tttccactgg acattgatgg aaagaccaag ttctaggaaa gttagtatag tgagagtgtt 53820
atatattatc ctcaccctag gagcgttttt gtcagcttcc actaatttgt ttttattgag 53880
gaagagtctg cagagtgtat gttgggaggc attccatggc agcgtttgta aatttcctgt 53940
taaagaagat taataaagcc ttcaatagat cccaggaagt tggattttta gtttttacta 54000
ctagacacag cattctgcct gcttatgata tatactttct atgctttttg ttttggttta 54060
tattagatgt ttcaaagaac tcaaatgtta atagaataat ttataaaatt accacatggt 54120
tgtctctctc agccagatat ttatcaacat ttatggggat gactgagatt ttaaaagttc 54180
acctgagatg agtatgtcag acaaaatcat ttagcctttg ttccataata ttttaaatct 54240
gacatttttt cagactataa tctgccacat gactgtcttg tatgatcttc tttggataat 54300
agtttctttt tttttttttt tttgagatgg agcctcgctc tgttgcccag gctggagtgc 54360
agtggcacaa tctcggctta ctgcaacctc catcccaggt tcaagtgatt ctcctgcctc 54420
agcctcagag tagctgggat tacaggcatg tgccatcaca cccagctgat tttttgtatt 54480
tttagtagag atgggtttca ccatgttaac ccggatggtc tggatctcct gacctcatga 54540
tccgccctcc tcggcctccc aaagtgctgg gattacaggc gtgagccacc atgcctgacc 54600
ggataatagt ttcttaatta agaaatgaga aacgtaccta ataaaaaaaa atgttgtgaa 54660
gtttcagagt ggcagaatca caccaccccg aagagcccct tcaccagatg gcttctcacc 54720
atatagccct gaggaaacaa accgccgtgt taacaaagtg atgcgggcca gactgtactt 54780
actgcagcag atagggccta actctttcct gattggagga gacagcccag acaataaata 54840
ccgggtgttt attgggcctc aggtaggatt cgtcaccatt ttatacttta ttagtagtag 54900
tatatggtac tacctcaaat ttatatacta taatgttctt aaatttagat caattaattc 54960
cctatagtaa acaaagttaa acttaaaatg tattttaggc taatattttt ctttaatgta 55020
tttatgaggt tttactatct taatatacca tagaatagaa atttgatcta tttaataaat 55080
tcagtgaaaa tgaaagatta aatcatggaa atagctgtag atttttctta tatacaaaga 55140
taatgaagaa tatgaattaa tagaaacttt agtataaaaa gttggaaata ttgtaaaagt 55200
gataaattta gaagttcttg tgaaccacag atgtattaac ctataggttt tctttttaac 55260
tctttagaac tgcagctgtg cacgtggaac attctgtatt catctgctat ttgtgatgct 55320
ccgggtgttt caactagaac cttcagaccc aatgttatgg agaaaaactt taaagaattt 55380
tgaggtagtt tttaataaat gcttagagta aaattgttag catattctta ggatatattc 55440
ttaaaattta tccttcacta aatttaggca gtgaccattt taaaggtgtg aaggtatgta 55500
agaattagtt gatgcttata aatagttctc atgagatatt tactaaactt tttcttctag 55560
cttgaaaaaa acaaacactg acctgctgta agaatgttgt ccttagtaaa aactataatg 55620
tgttcttatt tttgaagctc ttaaatcaac tttatgaaaa acatgcaaat taaagataaa 55680
taattcagcc tctagaactc ttcatatgta taattatggc acaaatatca ttgttactgt 55740
ctttttccaa tgttaggttg agagtttgtt ccagaaatat cacagtaggc gtagctcaag 55800
gatcaaagct ccatctcgta acaccatcca gaagtttgtt tcacgcatgt caaattctca 55860
tacattgtca tcatctagta cttctacgtc tagttcagaa aacaggttag tactttttaa 55920
ggatttcaaa cattaatcca gtgttacttt taattttagg ggtaattttt tatatctact 55980
tgttaagttg ctctaaaatg atttaattat tgaatcttgg ctttcaagtt aaaatcaagg 56040
gtgaagatac taaaagttcg ctgggcatgg tggctcgtgc ctgtaatccc agcaccttgg 56100
gagactaagg cagaaggatt gcttgagccc aggagttcaa gaccagcctg ggcaacatag 56160
ggatacccca actctacaga agtaaaataa ttagctggga gtggtgatac ctgtagtccc 56220
agttactcga gaggccaagg caggaggatc gcttgaaccc aggagttcaa gtctccagtg 56280
acctatgatc gcaccactgc ctaggtgaca gaacaagacc ctgtctctta aaaaatatgt 56340
gggtgtgtgt atgtatgtat gtctgtatgt atgtatgtat gttaaaggtc atgtgagtgt 56400
gtgtgtgtat atagacgttt tgtgctaaaa actacagcat tcatgtgaat cttctttctg 56460
ttctgtatat tgctttattg gttttagtgt aaaaattaga tttttaaaaa ttaatccaca 56520
aaggagtgct gcttctctta ccagggcacc ttctatgtta ttcccgaagt gcccagtttg 56580
agaagcattg ttctgagtgg ttaaatcctg tcttcatcct attaatctgt taagtattgt 56640
aactacctca aaattcatga agaatgaaaa agtgacaggg tcgtaacaag ggtgcagtga 56700
agagaagaga ggttttcttc atctgtggaa aaagtaaatg tttgaagaat tttcttaatt 56760
ttgattaaat gaaataattt tagaatccta gagttttacg agtttttaga cattgaagat 56820
tttctagttg gcatgtctca gtgacacagc gataagtgaa gccaagaggt tatgcagctc 56880
atttgaggaa aggtatagcc agaacctggg tatctttgtt ttacccctca tctcttctaa 56940
ataaaatgaa aaaaatgagc tttatttctc cagcctcctg aactcctagc cccaagcatt 57000
cctcccacct cagcgtccca aagtgctggg attacaagtg tgaaccacca cacccagctc 57060
ctttttcctt ttgagtgaca tttctgtaac tttttactgt ggagaaaaat aacagatgct 57120
taaaaccaag tagtcaaaat agaaagtttc tctctgaggt taaatatata tatttggatt 57180
tgcatatcca tggggggaat cacaaaagtt atcttggtta ctgagattgt actgtacata 57240
catagataga tttttgtttc gtataaccac tatttttata tctaagatca ataaaaagaa 57300
aatacagagg aaatttatct ggaggtctga ttacatacaa ttttaaatgt tatgcccaaa 57360
acaataataa aagaattagg ataaacaaat ttaaaattca attgaaaatg aagggcataa 57420
agagaatatc caccaaaaaa gaattttaag gggctaagaa acacaaaaac tgttcagtca 57480
acctaataac cgaagaaatg ttcatttttt aaaaaaagat accagttttt atttaccgaa 57540
ataatgaaga ctttttaaat gatgtaattc agttattgta agcatgtgct tgatcgtatg 57600
taaagccgta tagccttttg aagaaaaaag gaatatggct tttaaaaaca tttatattca 57660
ttgatccagt aaatgttctt cttaagtaaa agtttaatct gagaaatgca aaagcctcac 57720
atatatcata tatgactgtt tctcatagta ttatggtgaa aaagtagaaa cagtttaaat 57780
atccaacagc aattgaatga ttaaattagc atatgcccat gttacaaatg tcatgtaggc 57840
attaaaatta tgcttttgga gaacgttgaa tggcctggga aaatgtcgat aagtaaaacc 57900
aaatctaggt tataataata tattatgcat gaacccagtt ttatatagaa aaggtattac 57960
aagtatgtaa aaatcggaag gaataaaaac ttcactggtt attaatagga ggtgctatta 58020
tgggtaactt tttttaaact ttaaatattt tgtggtccat ttggtctctt ttaaaactac 58080
tcagctctgc ccttatatcc tgaaaatagc caaagacgat atataaatga acgggatggc 58140
tatgttcagt aaaactgtat ttacacaagt agtccacagg ctgatttgtt ttccttataa 58200
gttcattact ccctgctcta tacttgtaat tttgcttcag aaaaaactat gctaaaaaaa 58260
atctgaaacg tcaaaaaaaa atgagtacaa agatgtttgt aatggtttct ttctttcttt 58320
tctctttttt tagacggagt ctctctctgt cacccaggct ggagtgcagt ggcgtgatct 58380
tggctcactg caagctctgc ctcccgggtt catgccattc tcctgcctca gcctcccgag 58440
tagctgggat tacaggcgcc tgccaccatg cccagctaat tttttgtatt tttagtagtg 58500
acagggtttc accatgttaa ccaggatagt ctcgatctcc tgacctcatg atctgcccgt 58560
ctcagcctcc caaagtgctg ggattacagg cgtgagccac cgcgcccggc cgtaatggtt 58620
tcttaaaatg taaaaatatg gaaacagctt atatgtccaa cattaatgga tacttaaaac 58680
aggatctatc tagtcagtgg aaaattatga tggcattaaa aattatgtgg tggaagcaac 58740
ccaggtgtcc atcaataaat gaatggataa aatgtggtat atacacatag tggaatatta 58800
ctcagcttta caaaggaagg aagtgtgcta caacatggat gaacctttag gacattattc 58860
taagcaaaat aagccagtca caaaaagaca aatattgtat aattgcactt acatgagata 58920
cttagtcaaa accatagaga cagaaagtag aatgagccta ggtgggagga tatgttgacc 58980
agcctgggca acatagtgtg accctgtctg taccaaaaaa aaaaaagaga aaagaaagaa 59040
aagaaaaatt agccaggcat gggtggcatg cccctgtggt cccagctact caggaggctg 59100
aggcaggagg atctcttgag cccagaagtt caaggctgca gtgagctata cttgtgccgc 59160
tgtactacag tctgggtgac agagcaagaa cctgtctcaa aaaaatgtag aatggtggtt 59220
gccagaggct ggaggaagga gatcatggaa aatggtgttt aatgggtata gggtttcagt 59280
tttacaagat gaaaaggata ctggagacac atagtggtga tggttgcaca gcgtgaaggc 59340
atttaatacc actcacgtgt acacttaaaa atggttaaga tggtaaattt tatgttttgc 59400
atatgttgcc acaacaaaaa aaagaattat gtatatgaag agtttaagtg caattttata 59460
ataaaaattt ttaaaatatg aaatagtgca tatatataca taaatgatct gaacaatgct 59520
tacaaaatat gtacttggaa aaaagatggg caggaaatac cccggaatgg tattcttttt 59580
gttgtcagag aagtatttaa taagttgcac ttataatttg actaaattgt gaaactttat 59640
tttcctctat gaataagctt aattttggta taattatttg aagggttagt tgaccttgga 59700
ttatttttgc catgaatatt tttattatag gtagttgtat acatcatttc tgtaatgctg 59760
ctgttaattc tttgttacta atgcatgcat agtcttgaca gtttttcccc atcctaagta 59820
gctccataat taggaaaaga gatgggcagg tacatcagga gggacagact agtaagtgtg 59880
ccttcatcac aggaatcacg cattatgact ttgctgactt gtttgactag ctttttggaa 59940
agctttttgt gcatttgggg aactggttat tttgctggta gttactcaga tctgtttttc 60000
agggaaaagt agttactgtt tttgccatta cttctaatgg caaaattaga attaaaaaaa 60060
ttagaagtaa tggcaaaaac cgcaattact tttgcaccaa cctaatagtt taagatagta 60120
gaagtgcaat attgggccta gcttagcaga ctctgaaatt tatagatgtt gtaagtttat 60180
ggcatattct tctcagataa aagtgtaatg atagatctgc cacaaactga ttttatgatt 60240
tgaggcaact tatttaacat cccagagcct tgtctttata ttataatgaa aatacggcta 60300
ttgattttaa aagccatccc tcacatcatg aaggtttaaa taaaaacatt tatgaaatag 60360
aaaactaaag ccctctttag cctggctgca cacaaaataa ctactgttaa ctatttcata 60420
caacttttaa aaattacata aatcaaggaa tgaaactctt ctttgcacac ttcgtacttc 60480
agcaaacaca tgcacgcacg ttcccccatc catgtttctc tcaactttct tactgttttt 60540
aaacaaatac aaagtcatgc catatgttct ggtgtgcagt tttcttttac ttttacttta 60600
tatatcaaga atatttttcc acatcatcac caaattacat acttttttct tttcatggct 60660
gtataagatt atgttggtac accataattt atttagccat tgccttaatt aatgtacatt 60720
aagtacatct ccactttttg gtttacatac ttaaaatatg tagcgataac atcctagaaa 60780
ataggatttt taggtcatga atatatacca tgtagtattt taagaaatac taacaaaatt 60840
tccttccaga gattttagtt tttactccta ccagcagtct atatgagaac ctggttttct 60900
gtgccattat cagggccaga tgttaccaat ctattatttt ttattccaat tgccttttta 60960
tttcctttgt ccattgtact atttattagt atttttctaa ctgattttta aaagtacttt 61020
gtatgttaga aatactcaag tatatgcaat ataattaacc attatgttgc gattttgcca 61080
taaatggaat catcctatac atggtagttt tattttgacc tcatttatgg atttctctgt 61140
tcctttttaa aggcttcaag gtgtctgggt ttgccataat ttgtttagcc tctttttggc 61200
attcatttgg ttgttttgat ttcttttcgt tattctaaat aatattgcag tggacatttt 61260
catacatata tctctatata tttatctttt tattttctta cgatacattc ctagaagtct 61320
aggtgaaaga ttgtgtacac ttaaaatgtg atgtgttcct agattcattt ctgggaaagt 61380
tggatcagtt catactgcca ccagaaattt ctgaaatagg catttaaatt taggatgtgg 61440
aatctttgag ctctaaggtc cgccagtact taaaatcttg aaactggtac catgtagtgt 61500
atttttatac atagtcaaac ctgttggtct attcaaaagg tacagtagca gaatttgggg 61560
gatacaaatg tttctttcta agattgcagt ctgtgtattg aattgttttc atagcaaaga 61620
aggttaactc acacctacaa tctataaata ctcgtgtgtt aatctgattt taaattactg 61680
tatattaata gtgtaaatat gtatctctta gttatataag atgctcttaa gaatttctaa 61740
tgtatttata ttctaagcaa gcagaaagtg tttttagcat atccgttcta ctttatattc 61800
ttttatgctt aatacttttt cttccccttt tctatagcat aaaggatgaa gaggaacaga 61860
tgtgtcctat ttgcttgttg ggcatgcttg atgaagaaag tcttacagtg tgtgaagacg 61920
gctgcaggaa caagctgcac caccactgca tgtcaatttg tatgtggctc tttttctccc 61980
tatgcttact caacacagtt gctctctgag ctaactatgt tatttaagag tgtaacatgg 62040
cttgagggga aattggtgag agaataaaaa aagtatatct aagtcctaag tcctatgtga 62100
aaagttttca acaaatggga atgtaggatc tttaggagat gacctgtgtg agcaaagaaa 62160
tgcaataaag tgtgtgtgac atatgtgata atggaagaag tgcacagaat tagaaacaat 62220
ttcaatctgg aaggtataca tgaagggaag gaggtggaag aagacctggg caggcattac 62280
agaaaggcta gcatcaaagt aaggtttgga aggactttac ctggtagtca aacagggcag 62340
aatgttttga aaaatagtaa gcagagtaca tgttatcaga atgaataaaa tagcatttgc 62400
aaatcaaaat catttaacct gctgtgttta cttgctttca gataaacatt taattagatt 62460
atttttgagg ttccttctat ataaattcta taattataaa cagttatgaa ataaaaataa 62520
tgttaaacat ttacattttt gtaagatttt gtttctgtaa tttttcaggg gcagaagagt 62580
gtagaagaaa tagagaacct ttaatatgtc ccctttgtag atctaagtgg agatctcatg 62640
atttctacag gtaataattt tgaaatgata cggatatgtt taatttttaa aaatttctca 62700
gtgtggtttg tcttaatttt tttaaagcaa gttttgttat ttttcatttt agccacgagt 62760
tgtcaagtcc tgtggattcc ccttcttccc tcagagctgc acagcagcaa accgtacagc 62820
agcagccttt ggctggatca cgaaggaatc aagagagcaa ttttaacctt actcattatg 62880
gaactcagca aatccctcct gcttacaaag atttagctga gccatggatt caggtaagta 62940
gttctttgtt tttcatttct caaagaaata tttatagatc aattaatgta tttgtctcct 63000
tccctcagtt gttcataatt taaaaaaaca cttttacttg cctccatcat gaccttcatt 63060
ccactggaaa ttttaatgtt acttttggta ttaatactat actgcttatt gtacagcttc 63120
aacttcaaaa cttcttgtgg tttcacttca catatctaga aacatctctt cctgaactaa 63180
cggacatacg gggttattca aggatagaag gatagaaacc agaacccttc aatgctaact 63240
tttcccaatg tttaatcccc gtgcctgcca agaattttta tcatgtttct tatttgctgc 63300
catttaaaat taatttctct tttcatatcc taatggcata caatgggtgc ttaataattg 63360
cagaggagat gaataagaaa aaaatatgtg atggttacct tgagttcatc atttttattt 63420
gtaagaacag tttcccatcc ctttaccatc tcttctgatt gaatgttttt tcatcctcag 63480
taagtagggc ttttttgtca gttggtttgt aatgattttc ttggttgttg aatgctcagt 63540
ctattatttt ttaaatgtag gatctaaaac cagacgggtc tccagtagac aataataaag 63600
taaaataatt attttcaata atctgttaaa ttctgttgaa ttaaatttgt gaacaggtgc 63660
attaacacat tgagcttata tatcattagg atttgttaca tttttctttt gtgaccatta 63720
cagtcctgca gctttggaat tctcttagca tattagcaac ccatttatga atctaataaa 63780
atctgcaaaa atattaaaca cattcttgta cctagttcat taatgaaatt taatgaacta 63840
ttaatgaaca taggccctca cctgcccttt catgacccat caaagaactc tcaagttgat 63900
tctgagctgt tagagttcat tctttcaagc atatggtcta gtttgttttg cctaagcttt 63960
aggtcagact aggctctaca ttcctagctt tttattaagc atgttaggta agacagttaa 64020
aacataggta gtggtacact acttaacagt accagaagct cactatattc tagttggttc 64080
attctcccat aatatccctt tataacaaaa catatgtaaa taagtatgtt atgatctgtt 64140
tttcaaaagt tgtgtttatt catctttaat atttaggcat ttttcacata atgaattatc 64200
ttaggtatta agcttacttt tagctaattg gcccataatg tcaagaccat tcaccctttc 64260
ctcactgtag ggactctggc ttttggggca tggtattgac gacgataaca gcatatacta 64320
taattctacg tctacattta tcctttgctt actcgaacac aagcattttt tcttcagttg 64380
tttgatttgt ccactccatt cgttttacag tcctacctgt tttgtctagt tttttaaacc 64440
tttttataca gacaaaaacc aattaaatgt gttttgctta ttgctcttgt ctgtaagaga 64500
aatactctat atctcttgaa accttctcct ggtgcttttt ttgatttgtt ttttgtttgt 64560
ttgtttgttt tcttaatctt gctccagttt ttctctttaa actaccttaa tatgaataca 64620
gagttgaggt tttcacagtt ttttggcgtt ttggtaagca tgtgggacag tagaggcata 64680
gaatgtatgt atagccatct agtgacttaa tggagcttat tattaatttt acctgagcta 64740
ataaatatta atgactttgg ataattatca gttaaacttg agtataaaat tcttccttat 64800
gatgcttaag tggctggata tatttgaagt tgtgaaggat ggtaaagatt tcagaaatgt 64860
ccagttttta cgtagtaatc aaaaatgatg ctaaactcaa aatgctctgg gtccataagc 64920
ttttctttac attgaattca tcgtgtgtgt ttgatacagg tgtttggaat ggaactcgtt 64980
ggctgcttat tttctagaaa ctggaatgtg agagagatgg ccctcaggcg tctttcccat 65040
gatgtcagtg gggccctgct gttggcaaat ggggagagca ctggaaattc tgggggcagc 65100
agtggaagca gcccgagtgg gggagccacc agtgggtctt cccagaccag tatctcagga 65160
gatgtggtgg aggcatgctg cagcgttctg tcaatggtct gtgctgaccc tgtctacaaa 65220
gtgtacgttg ctgctttagt aagtagcttt attccataat catatcatta tgggtttggg 65280
gttttttgat ggttcgtaga tagtgttttt aagatacaat aaagctactt tacctaattt 65340
tggaaaatcc aaattttatt tttattccat aattccagga aattacagct tttgttttgt 65400
ttatttgaat tttactgatt tttatgatgt ccaaggtttc ttatataact gttttacttt 65460
ttagtttcat tgttttaaag gctttgcagg ggtatccaag ggagagaata tagtcatggt 65520
ttcttagttt ctgtttgggc cagtaaagct ccttcctcat cctccttttc cacttaccac 65580
tagagacaga ctaaaaacca tggcttcagg ctgctaaagc ctaaaacaaa acaaaacaaa 65640
acagaacaac aacaaatagg gtgagctaga caagcttgct aatttttaaa gattttttta 65700
atgtcttgct gttcatatct gtacattttt ctgagcagat accttataca tgaccaaatt 65760
aaaaatgctt tttgggatgg cagagtcatc aacgttattc tgatttttta aaaaatttat 65820
cagatattaa ggaagatatg tttttaataa acattttgat tgatttttaa taaacattgt 65880
catgtggaga ttcaaaagcc ttttcaaaga aaagggttcc atgacataga tcattgagtt 65940
gttttccagt ttaacctgtt aaaagttctt tcatgggtgg aatagagtga caaggaggta 66000
atttaggaga ctaactggac tttctccatt ctgcgtatat gtctctttag ggcttctcag 66060
cctcagtact attaacattt gttagataat tatttgttgg agggtggggg gagggccagg 66120
gatgttgtca tgtgtgtact gtggcagcat ctctggcctc tacccattag ataccaggag 66180
caaacccacc cccacccgat catgccccca gttatgacaa ccaagaatgt ctccaggcat 66240
tgccaaatgt ctccagtggt caaaactgcc cccaattcag aatcactact ttaattctta 66300
tctagtctgt tcttaaaatt catgagcagt ctgtaggctt cctccctcag tctttttcta 66360
atgcatcctc taccgattgg gcctaatgaa tcttcttgac aggtaataca gcatgacagt 66420
tacgaacatg ggtttggagt cacaattgag tgatctcata atttatcatt ccaaccacaa 66480
tgcttgcata atgtgctggt taaagttgga ctagcctagg caatctgaac acatgatcaa 66540
gatcatagag acagacctgg attcaaattc tggttctccc ttttactagc acgatggctt 66600
tatgaaggtt acttaacctc tcttaaataa acttcagttt tctcacccat aaaataatga 66660
aaataccttt taggtttgaa attagattat gtagaaactt tcaaccatat gcctggcaca 66720
ttgtaagaac atttaatatt atataatagt tatcattatt tcttaaacac aacttggatt 66780
atcccccaaa tcatttagaa acctttagag gtttctgttt ctttgacatt cctaaagcat 66840
attctgtgga agtttggcag ggttgtgaaa agttccctga agaaagaatc ccgtattcag 66900
ttaagattgg tgaacactgg attacacaag gataactagg tctgttgact gaaaggcttc 66960
taggatcctt cagtaagcta atgtacattg tgaacctaaa ggatcaaagg atagaatgca 67020
ttgtttccca gagttatttt gctacacctt gttttttcat gtagcatctg gagggaccag 67080
catactatag aataaagacc aattggccca atattttgcc tcttacttag tattttccaa 67140
cacaaacctt caggcatact tgactaaata aaatcctctt tttgctagtt ccttttctgc 67200
aaagcctttg ctgtgttact ctttttgtac acaccgtaac tgccttactg ttgtggttgt 67260
ttcttcttaa gttcagactg tttcccaact agcttatgag atcctagagc acaaagattg 67320
tataaaggat accaggctcc atggaggcag aaatggctcc tgctgttaag gctcaccctt 67380
tccctttctc ttatctcccc ttcctctgtc tcttcctttt tttcctctcc ctccctctgc 67440
atatataatt tttttttttt tttttgctga atcgtttgag agttttttgc agcatcatga 67500
cacttaaata tgtgtctctt aaaaccaaat acataattcc atttattctt ccatatacag 67560
tcagcacatt aacattaatc acaatactgt tttgtactat aaagttcata ctcaaatctc 67620
ttcagttgcc caacagtgcc cttcatagct aaactgcaga ctttattcag atttcaccag 67680
tttttctgct gttgtctttt ttctgttcca ggatccaatc caggatccca cagtgcattt 67740
agtcaccatg tccccttaat gtcttctcat ccatgacagt tcctcagcct ttcctggttt 67800
ttaatgacct tgacagatac tttcaaagtt tactggccag ttattttgta gaatatccct 67860
caatttgggt ttatctgatg ttttctcatg attagatgga agttacgtat ttttcacaag 67920
aacgccacag aggtgacagg cctttcttag tgcatcatat cagtgggtac atatgcccat 67980
ggcttttatt attggtgatg ctgtcagtta aggtaatgtc taccaagttt ccctgctgta 68040
aagttaatat tcctaaatat cttgtgagag ttactttgag attatgcaaa taccctattt 68100
cacctcaaaa ttttgtccac tgattttaaa agcatttgtg gatcttgcct atagcagtta 68160
ttactacacc attaaaaatg gtgctctctt gggcacaggg aggggagcat cacacactgg 68220
agtctgtcgg gggtcgggag gtagaggagg gatagcatta caagaaatac ctaatgtaga 68280
tgacgggtcg atggatgcag caaaccacca tggcatgtgt gtacctatgt aacaaacctg 68340
cacgttctgc acatgtaccc cacaactaaa gtataattta aaaaatggtg ttctagtggt 68400
gattttctat tttcctcatt ccttctacat taattaattg gaattattct ataaagaaga 68460
gcttctctgt ttatatacct attcaatttt taatttgtat tggtgtaggc tcctgggtat 68520
tcattttgtt ctgtgggttg caacccagta ctaccatcat ttgttttgtt gctctaatta 68580
ttccagcctt gaccattggg agctctttca ggttggcgcc tgttctcatt ttctttttta 68640
aaataatttt ttttaacttt tcatcttgaa atgaattcag acttttaaaa attgcagaga 68700
aaagagttca gaaaattcct tcctgcccca ttcatttatt ttgttagtta gttgtattat 68760
tacagaagca tggaattctt attttattct atgggttata atccattcct gtctacttat 68820
tttgttgctc aaattgtctc aaattaggcc attatctctg atgcttttta agtgtacata 68880
aactgacctt cagatttttt tccttagaaa acattgagag ccatgctggt atatactcct 68940
tgccacagtt tagcggaaag aatcaaactt cagagacttc tccagccagt tgtagacacc 69000
atcctagtca aatgtgcaga tgccaatagg taaggcttta ttgatgaatc acttcaaacc 69060
ctcttgtctt aaaagtgcct cgcagcaagc ctcacaccta gtgtgaatat ctgatacatt 69120
ttattaaatg agtctttgaa cattgtcttt taatgtgaga tttaaaatga aaatgcagca 69180
taaagctctt aaggactggc ggaaagaact actggcaagt aaaagccagg caaacaaact 69240
gcatggatct ccacattatt gtattgtgat ttactctctt tagtaacatt cataatctga 69300
agaccagtcg ataagaacag tagttgacat ttatatctat aagttataat ctcatattag 69360
agtatgggtt acacagaata ggaaccagta agatcattac acctgcatat gccttattat 69420
caggataaaa aattaacaaa tccatctcat tttcagtgta gtggaatttt actctactta 69480
tgacagtttt gtcaaaaaat ttttagattt tttatattcc tgcaatatcc ttaaaaattg 69540
acagggaaca agaataaccc taactggaaa gaaaaatatg aagtagagaa ttgaggtaca 69600
atgacagtaa agatgagtac aagccatgct tttttcagac caatggttct cttttatttt 69660
ccccttccat aaaataggag gaaaagatca attttcattt aataatcaca gctactgtga 69720
acagttattt ggtagttcct atttctttct atcccagcag atcttggtta gcaagaagtg 69780
ttgaatctcc cttctgttgc ctcttccatt tcacccattt agagttctct cagtacaacc 69840
tttctcttcc tctgcaagtc ataatgactt agtttgcaca ggatctcaaa aattaggtac 69900
ctacctttaa cgaatttctc atatcatgaa gtctgtcttt tgcctctatt gttttctcta 69960
tagattgaaa atattggatg tttccttgtt gcttagagaa aacattgtat atctgtaaaa 70020
tattgcaaat taacaagtaa tttgcaaaat gcataggaaa aatgtcattt ttaaatatta 70080
gaataggtat atttctgaga attcagtgtt ctcatggtat ttgttatgct gctcactttt 70140
tgaaactcca aacttaggtt gtttacctgg tcacctgaat gactgaacat aagaaatact 70200
gtagagagat tttataatat tcagacctca ttttggctat gtaaggaaat ggagggtttt 70260
tggataggaa ggttttgttt ttaattcaag agcttcttag tgaaagttca gaaatcaaaa 70320
tatcaaggtc cttgtttttt cttttaacaa aatataagac ttttatctga tttggtattt 70380
aaatcagtac ttgcaaagag ccattgttga aaattctgtg cttaacatag gggatatgtt 70440
aaatttacga aattagacct aataaatgaa tattactact tatggtgaca ttgttaatat 70500
gattttagtg gtggaaaagt aaacactcct gaaaacatta tttctccact ttttcacaag 70560
gcattacatt actcctctaa tattgtatag tgttttagcc aagatccagg attgatgttg 70620
cttttccttt gtttttagcc gcacaagtca gctgtccata tcaacactgt tggaactgtg 70680
caaaggccaa gcaggagagt tggcagttgg cagagaaata ctaaaagctg gtaataactt 70740
ttcacttaaa aggaatatag catattttat catgttcctg agcagccttg tctaatctca 70800
taatctctca tgaggcagtt tacaggattt tgaagtaatt ttataaattg attcactgtg 70860
ttacagttag aaatgtgaat tactctgaga gagaaattct ttaaaatagt tcagaatatt 70920
tttgttggcc ttacaccatt taatcatgtc ttgttttaga ttttaatatc actatttttt 70980
aatcatttat ttttactttc ctttttgtag gatccattgg tattggtggt gttgattatg 71040
tcttaaattg tattcttgga aaccaaactg aatcaaacaa ttggcaagaa cttcttggcc 71100
gcctttgtct tatagataga ctgttgttgg aatttcctgc tgaattttat cctcatattg 71160
tcagtactga tgtttcacaa gctgagcctg ttgaaatcag gtaatttttc ttctgaaaat 71220
gtattacttg tatcttccta ccctccctac accctcctca agaatgacac attttagatt 71280
tttgaaagac tcagagcatg aataggttgc tgatacctta atatttgatt gacatatgaa 71340
aacccaaagt ctgggctctt taattaaaaa ttcatagata ctttatgctg aaatggtttt 71400
tgaagtatac atgctgtaaa ttactaccat tttttaagtt tccatgtatt tttcagtaat 71460
tggaacttat atggtaatga atgttttttt ctttcaggta taagaagctg ctgtccctct 71520
taacctttgc tttgcagtcc attgataatt cccactcaat ggttggcaaa ctttccagaa 71580
ggatctactt gagttctgca agaatggtta ctacagtacc ccatgtgttt tcaaaactgt 71640
tagaaatgct gagtgtttcc agttccactc acttcaccag gatgcgtcgc cgtttgatgg 71700
ctattgcaga tgaggtggaa attgccgaag ccatccagtt gggcgtagaa gacactttgg 71760
atggtcaaca ggacagcttc ttgcaggcat ctgttcccaa caactatctg gaaaccacag 71820
agaacagttc ccctgagtgc acagtccatt tagagaaaac tggaaaagga ttatgtgcta 71880
caaaattgag tgccagttca gaggacattt ctgagagact ggccagcatt tcagtaggac 71940
cttctagttc aacaacaaca acaacaacaa caacagagca accaaagcca atggttcaaa 72000
caaaaggcag accccacagt cagtgtttga actcctctcc tttatctcat cattcccaat 72060
taatgtttcc agccttgtca accccttctt cttctacccc atctgtacca gctggcactg 72120
caacagatgt ctctaagcat agacttcagg gattcattcc ctgcagaata ccttctgcat 72180
ctcctcaaac acagcgcaag ttttctctac aattccacag aaactgtcct gaaaacaaag 72240
actcagataa actttcccca gtctttactc agtcaagacc cttgccctcc agtaacatac 72300
acaggccaaa gccatctaga cctaccccag gtaatacaag taaacaggga gatccctcaa 72360
aaaatagcat gacacttgat ctgaacagta gttccaaatg tgatgacagc tttggctgta 72420
gcagcaatag tagtaatgct gttataccca gtgacgagac agtgttcacc ccagtagagg 72480
agaaatgcag attagatgtc aatacagagc tcaactccag tattgaggac cttcttgaag 72540
catctatgcc ttcaagtgat acaacagtaa cttttaagtc agaagttgct gtcctgtctc 72600
ctgaaaaggc tgaaaatgat gatacctaca aagatgatgt gaatcataat caaaagtgca 72660
aagagaagat ggaagctgaa gaagaagaag ctttagcaat tgccatggca atgtcagcgt 72720
ctcaggatgc cctccccata gttcctcagc tgcaggttga aaatggagaa gatatcatca 72780
ttattcaaca ggatgtaagt atagattctt taagaggtta gaaaacttcc ttggggctgg 72840
gcacagtgac tcatacctgg aattccagca cttggggagg ctgaggccga aggattgctt 72900
gagcacagga gttcgaaact agcctggtca acaaagcaag accctgtctc tacaaaaaat 72960
tttaaaaatt agccaggcat gatagtgtac acctggggtc ccagctactc aggaagctga 73020
ggtggggagg gtcacttgaa cctgggagtt tgaggctaca gtgagctgtg attacaccat 73080
tgtactctag cctgaatgac agagcaagac actgtctcac agagagcttc cttggaccat 73140
actaaaataa acctaattca gaaatgctgc ttctaacatt cagaagcaga gttttccaca 73200
taaaattatt acttatacaa caataatgtt tgtactgttt aaacagcaat aattcttgcc 73260
tatgggcatt tccggttaat tgtataatgg tgattacttt tgcatttgct gtcggtcaca 73320
aataccttcc attcagaggt cacatttata ggtggtttgg gaagccagac tgaataagaa 73380
taatatcttg cagactaatt tcacaaaatc ttactccttt aacagtaaaa agattgcttt 73440
cgtttaatat gtagacacca gagactctac caggacatac caaagcaaaa caaccgtata 73500
gagaagacac tgaatggctg aaaggtcaac agataggcct tggagcattt tcttcttgtt 73560
atcaggctca agatgtggga actggaactt taatggctgt taaacaggta aatatctagt 73620
gagcatataa atgaaatgac tcaaatcaca aaatgaagca tgttcagtaa aaagaataaa 73680
ggatatgtcc acgtgtgtgt actttagttc tttaaacttt gagaaactta gtttcaaagt 73740
agatgtttct aaagcaccag aaacatcatg aattctgtta ttgttaaaag ttgaggccac 73800
gcgtggtggc tcacacctgt aatcccagca ctttgggagg ccaaggtggt tggatcattt 73860
gaggccagga gttcaagacc agcctggcca gcatggtgaa accctacctc tactaaaaat 73920
acaaaaatcg gccgggcagg gtggtaggca cctgtagtcc cagctactca ggaggctgag 73980
acagaagaat tgcttgaact caggaggtag aggttgcagt gagccgagat cgcaccactg 74040
tactccagcc tgagcaacag agcaagactg tctcaaaaaa aaataaataa aagttgaagt 74100
atgattattg taagactaca atatcaagat gggccttaca aaggtttttt tggttttgct 74160
ttttgtaggt agtagaggtg gttttcaggt acttctttca acagtgtact tgtgcggtgc 74220
catcttgggg tttcagtggt ttacttttta ttataacgag catacttaat caggatagga 74280
aaattattaa actttcattt ttaaatcatg ttgattcttc tcccatattt gggcttttct 74340
catctttact ctgagactat tggaatattg actatatccc aatatttttg tcatttttct 74400
gatgtttact gctgcttaag ctagattctt agtgtttaaa agagtttgac ttgggtttgt 74460
ttaaagtaca ttgcatccat aagcataaat gccatctgtt gctaataaag tgctagtttg 74520
catttgttca ttttagatca gattgctagt gaaaatatgc aaaactttgt gaacgtgttt 74580
atttgaaaca ggtgacttat gtcagaaaca catcttctga gcaagaagaa gtagtagaag 74640
cactaagaga agagataaga atgatgagcc atctgaatca tccaaacatc attaggatgt 74700
tgggagccac gtgtgagaag agcaattaca atctcttcat tgaatggatg gcaggtatgt 74760
taatgtttta aattacaaaa tagtagtacg tggatttaac tttctgcaat ttaggaaaaa 74820
ccagtttaat taaaatttat ttctatcaaa tagtttgggt ttctaaaaac aaatcacccc 74880
aatatattag tatgaaccac aaatacttcg ttttgtattt catttactat aaatgaaata 74940
ttgactacct ctacctttta aatttttcca gtgtgttttt aaatgattgt gtagcattgt 75000
tgtttttaat acttgatatg tataagatat gtatatttcc aggtagccat gataaattgg 75060
acagatgagg aagtgtttta acataacaat atacaaacaa aattaacata taacttgaaa 75120
acttactaca agtaaactag cactgaagca taaagttgaa ccttgtcatc tgctgaaata 75180
aatgaagact gagttttatt ttgtattata caatgtatac aataaaatta atgacctgat 75240
gtgatgaaca gattgtttgg tttaacttct tagatttgtg tgtgtattta agagtgcatt 75300
tctctttacc agtcagttct taagtatgtt atctgttggt tggtcttaat aaagatttac 75360
actacagtag ataggttgac tactataaac acttttaaaa gcggctaaat ttgagacatg 75420
ttccaggtca gagctagtaa atggtagaat atgacgccta actctgggtt ttctgttcct 75480
cctcccattc tttccacctt ttactacata atatgttaac attgtttact ttagtcatta 75540
ataaagttgt tttgtgtatt ttgagaagac agagaattga attgtacatt tcagaaatag 75600
tttaatccga aattgttaac ttttacagct ttctgaaatc ttgactctcc aataaactgg 75660
tttccctgtg ggttctgtga aaatgtctcc taattagtag gtttttgaga tgatacagga 75720
atatgttagt tttgaaatgt ttttcttctg tttcagatgt gaatgtgagt tcatgcagtg 75780
aaaactttag aaaccaaagt gtaataaata cttttaattc tgtcttaagt ttatgataat 75840
tatttctatt gtcttatagg gggatcggtg gctcatttgc tgagtaaata tggagccttc 75900
aaagaatcag tagttattaa ctacactgaa cagttactcc gtggcctttc gtatctccat 75960
gaaaaccaaa tcattcacag agatgtcaaa ggtgagaatt cttctaatta ttatctagtg 76020
acaataaaaa aattaatttt aaaatttggg gccaggcaca gtggctcaca cctgtaatcc 76080
cagtactttg ggaggtgaag gcaggtggat cacttgaggt caggagctcg agaccagcca 76140
ggccaacatg gtgaaaccct gtctctacta aaaatacaaa aattaacagg gtaaggtggc 76200
gcatgcctgt aatcctggct atttgggagg ctgagacagg agaattgctt gaacccggaa 76260
ggcagaggtt gaagtgagct gagatcacac cactgcactc tagcctgggt gacagagtga 76320
gactctgtct caaagaagaa caaaaaaatg gacctttgtt gatagtttct aacagtggga 76380
tttttttctc tgagtaattc agaatattag aactgaaatg agccttaggg atcatttaat 76440
ctgccttcct cgtttaatag aaaagtacat tgaatacaag agaggctgtg ccttttctac 76500
agttttattg ctagttaatg gcagaaagta tacaacacag gtctccagat tccctgtctt 76560
ggcctcatga tacgctgact cccagaaagt tccttttcct ggttttattt tgaataattg 76620
ggatattggg atatcatcaa cttcttttaa gaaaaattcc ttcaaatcct ttgtaggtcc 76680
cattattttc cttatccttt tctttttttt ggagacaggt tctctgtcac tcaggctgga 76740
gtgtagtgtt gcaaacttgg cacactgtaa ctcatttcct gggctcaagt gatcctccca 76800
cctcagcctc ccaagtagct aggacaacag gtgtgcacca ccatgcctgg ctaatttttt 76860
atattttttg tagagatggg gttttgccat gttgccccca ggctggtctt gaactcctgg 76920
gctcaagcga cccgcttgcc tcagcctccc acagtgctga gattacaggc gtcagccacc 76980
gtacctggcc tcagtttatt tttctcaaga gcaaatttgg ttttctgtca ttagtctttt 77040
tagctagtat ttgacataat gtgttgaagt aattttataa ctttttaaat taagctctaa 77100
ttatgaattt agcgtacgct agagagagct gtgtgccttt agcaagaatg aagtgaaagg 77160
aaaagagaat aactgtttgc acctctgaca tgtagttcac ttctttcttt tgtcattgtc 77220
ctagttcatt agtattgtac tgggctttta tctgtcctta tttttgtttt taacatacaa 77280
ggtcatttgc tgtgtttgtt gacaggtgcc aatttgctaa ttgacagcac tggtcagaga 77340
ctaagaattg cagattttgg agctgcagcc aggttggcat caaaaggaac tggtgcagga 77400
gagtttcagg gacaattact ggggacaatt gcatttatgg cacctgaggt gagaagcatc 77460
tttgagtgtg atgacagaaa atattttgga attctgtgta acagcattat actaaattat 77520
cttgcagtgg tatccagtat gtacttacca actagaagtc cgtggccctt aaaatacggt 77580
tttaataata tctttcagac ccttattctc gacctttctt tgccttggca atattcaaaa 77640
aacaggtttt aatagattta cttaacggct gttactaata aagaattctg gggtaattta 77700
tagcagttgt tttgtaataa actcaaagtg cacataagaa atttttaaaa atattctctc 77760
tctattctaa aaggagatga gcatacagag gcagctcctg tctgtagtgg aaggagttta 77820
agcattgttc ttctgactca gcttcttctg tcgtgttcat aattcttcat gttcatatgt 77880
agtaatgatc tgttgtcctc ttgccacata gtttgctaag agcaaaattc tgtgatggga 77940
ctctgcttca gaatctcaca attctccaaa atatttttgt gctacctgga aaattaagct 78000
cattaatgaa ataaattaga tattaggtag tccacagaat tcctgtttgt accagttttc 78060
tccctaaagt aaggaagtag aatctataac tacaaaatgg ccttctcttt ttcaaatgag 78120
tcctatttcc aaattaactc tgatttattt taggtactaa gaggtcaaca gtatggaagg 78180
agctgtgatg tatggagtgt tggctgtgct attatagaaa tggcttgtgc aaaaccacca 78240
tggaatgcag aaaaacactc caatcatctt gctttgatat ttaaggtaat tgtgagataa 78300
aaattacttc tttgtgctaa aaggagtaca gcagaatttg gcaggaggca aattttgatg 78360
ggttctccct aacaatctag catgaaggta aataaatagt ctgtatattt attcagagag 78420
gatttgatat acaagttttt tactttaaga tggtgcaaaa gcaatacaaa tttggtaaaa 78480
accatacttt gaattttgat ttttgtctga gctagcaata tgtgctatga tacactggtg 78540
atgctaggca gtggcagcga gtcacagctc ccagtcagcc acacaatcac gagagtgaac 78600
aaccaatact ctatagtgga ctgtgttgtc agatgatttt gcggaacagt aggctaatgt 78660
aggtattata agcacattca aggtaggcca gactaagcta taatgtttgg caggttaggt 78720
gtattaactg cattttcaac ttaaaaaaat atcatcaact taaaaggggt ttatcacgac 78780
ataacctcag cgtaagttga agagcatctg tgtatgtgtg tatttccagg agttgatatt 78840
gtcaatggtg ttgtcaatgt tagtgacata catagtcact tcttgttatt tgaggtagtt 78900
atgctctgtt aagttgctac aaatattgaa ttagcaaata ctaaaacact gcttctagaa 78960
gaaatatgta gtgtgtttat atgtatatgt atgtgtgtat atatatccat ccatcacttt 79020
aaaaacgtga aattcatgca ttttacataa ttcaaaaatc ttaaaatcta atttaccatt 79080
ttcttttgtt cgtttgtttt ttgtttttgt ttttgagaca gagtctcgct gcagtgccca 79140
ggctggagtg cagtggcacg atctcagctc actatagcct ccgcttccca ggttcaggca 79200
gttctcctgc ctcagcctcc caggtagctg agactacagg cacgcgccac catgcccagc 79260
taatttttgt atttttagta gagatggagt ttcaccatat tggccaggct ggtctcgaac 79320
tcctgacctc aagcccacct cagcctccca aagtactggg attacaggcg tgagccacca 79380
ctcctggcct aatttactat tttgtatatt ttaaaaattc acacccaagt cagttcagtc 79440
ctgtctgcct ttcctacttt tttataactc acaaatccat tctctccttt tccaccatag 79500
aataagtaat ggttgatatt cttagctttt cagtagatgt gatggttgaa atcatgggct 79560
ttggagtcac actgacctag ttttaaaccc tggctctacc ccttaatggc catgtaatca 79620
taggaaaatt attttttgtg tctaccctcc attttctcac atgtaaaatt ggtgcaagaa 79680
ccccatgaag catgtacttc gtgggattac tatgaagata aacaaaatta tacctaggcc 79740
ttagtcaagc actcagccca cacagtcagc tccacctgcc ataacctcct ccagtgctcc 79800
ccacacttat tatataacct cctcagtcac ctctctgaca atacctgttt tgtattatca 79860
cctcatttcc tctattcttt cagacgtccc atgtccgttc tctacgtggt tcaaattctt 79920
attctcttta aggcccccat tttgtgcttc tcctgcttgg gcaccccctt tttactcatt 79980
ccagattctc atagcatttt agtacatact tgtttctgac actttgtttc ttgtttgcta 80040
gttatgttcc tatcttgctg cctctttcaa actaattctc cttgaggtcc attcatgtct 80100
gattcatttt cttcttccca gagtcttata cagaagttgc tcaataaata ctcatggcta 80160
ggatcaattt gaaagtttga tgttatttta agagttttga tgagaccctg gaaacaattg 80220
taaataattt tcaaattggc acagttcata ttttaacaga tttcattgca ttctccttcc 80280
taggtagagt ttaaagagaa ttgtactgta acattttcag tttccttaat ttggagtaaa 80340
tactttgagg tttttggaag caccccaaag ctttctcaaa cacttccata ccctgtttat 80400
ggtagtataa attgccatag cacgtttttt tagagagtga tttggcaata tctgccagaa 80460
tttttaatgc acttattctt tgactcagct atgcccattg ttaggaattt actcaagatt 80520
acctctagaa gtaccaagtg ccaagttcag gattattcac tctactcaag aaagtaatta 80580
aattatccac actatacaga aattaaacga gtatgaagct gttggtgttg atttacaaag 80640
tgctacaaga tacattaata agtgaaaaga gcaaggtata taaagtgatc ctggccaagc 80700
acagtggctc atgcctgtaa tcccagcact ttgggaggct gaggcaagaa caaaacttga 80760
acccaggagt tggagagcag cctgggcata gcgagacccc atctctacca aaaaaaaaaa 80820
aaaattagct gggcatagtg agacgcacct gtgctccagg gtactcagga ggttgaggtg 80880
ggaggatcgc ttgagcccag gaggtcaaag ctgcagtgag ccatgttcat atcactgcac 80940
ttcagcctgg gtgacagtga gagcgagacc ctgtctctaa attaagtttt ctcttttgta 81000
gacattttag aaaatcttaa gtctgtgaat atattggcct tttttcctcc acaaaacaca 81060
cacagacaca cacacacccc ccccccccac acacacacac acaaatcatc agtaagttac 81120
atttggggaa aagaaggaag agggactttt tttgttttgt atttttcctt tttgtggtgt 81180
gtaagatgtg tatatatcag ctgagtatat catgatacag gatcacagac cttagaggat 81240
ttttctttat attactttgc attttttaac ccaaagcatt tatgaaatta ctggggtagg 81300
gaaaagagag ttttcttgtg attaggagtg gataggtgag tttaaagtat tcagacttga 81360
tattagccct ttgtcagatg agtagattgc aaaaattttc tcccattctg taggttgcct 81420
gttcactctg atggtagttt cttttgctct gcagaagcgc tttagtttaa ttagatccca 81480
tttgtcaatt ttggcttttg ttgccattgc ttttggtgtt ttagacatga agtccttgcc 81540
catgcctatg tcctgaatgg tattgcctag gttttcttct agggttttta tggttttagg 81600
tctaacattt aagtctttaa tccatcttga atttttttat aaggtgtaag gaagggatcc 81660
agtttcagct ttctacatat ggctagccag ttttcccaga accatttctt aaatagggaa 81720
tcatttcccc atttcttgtt tttgtcaggt ttgtcaaaga tcagatggtt gtagatgtgt 81780
gggattattt ctgagggccc tattctgttc cattggtcta tatctctgtt ttggcaccag 81840
taccatgctg ttttggttac tgtagccttg tagtatagtt tgaagtcagg tagcatgatg 81900
cctccagctt tgttcttttg gcttaggatt gacttggcaa tgtgggctct tttttggttc 81960
catatgaact taagtagttt tttccaattc tgtgaagaaa gtcattggta gcttgatggg 82020
gacggcattg aatctatgaa ttaccttggg cagtatggcc attttcacga tatcgattct 82080
tcctatccat gagcatggaa tgttcttcca tttgtttgtg tcctctttta tttcattgag 82140
cactggtttg tagttcttga agaggtcctt cacatccctt gtaagttgga ttcctaggta 82200
ttttattctc tttgaagcaa ttgtgaatgg gagttcactc atgatttggc tgtttgtctg 82260
ttattggtgt ataagaatgc ttgtgatttt tgcacattga ttttgtatcc tgagactttg 82320
ctgaagttgc ttatcagctt aatgaaactg aagaatgcta aagacaagaa ggaaccaaag 82380
agaaaagaca aattacaaga aaaaaaattg ataacaatta tatggataac agaatacagc 82440
agcaacaaga gaattcaaaa gacaaattgt accttctagt gattgaaata aaataacagt 82500
taacctagga tttcatagct agctaaatga tcatcaaaaa ataagaatga aatagagata 82560
ttttcagaca catgagaatt gtggaagttt accttcagca gacactcact gaaaaaaatt 82620
atttttagga atgcatttca agaagaagaa aattgatacc acaaataggg agatatgcaa 82680
gaaagacact atctctgcct ggagtcagct ctgattcata atgggtgctc aaaaattgtt 82740
agaaaactaa tacttttttt tatatatgac ttgaaattaa aatatggtta ttgcagcaca 82800
aattttagaa tgtaaagagt gtatcacaat ttaaaaataa ttatcagatt ttgaattttt 82860
ttagaaaaac tacaaataag accaaataaa atttcttttt ttttaaaaaa aaagtattca 82920
gacttacaat ttgtttataa aaaagttatt cttcatagtg tatttgatac taagaatcag 82980
aatttgtcca acacggaagg aaaaaaacaa tgcagttgtg ttttctatgt attaaattga 83040
ctcttcagtt ttagtctttc ttaatctaaa tagctctgta tgctgaagaa atagaaaacg 83100
tgcagtaaga acaaaccatc tcggagattg aatatgagga cagcagaatt catttgagtg 83160
aatactttat ctacctgaac attttgatgt acttagcctt gttgatgtaa ataataagga 83220
ataggatata tttgatcaaa tcctaaaatc ctaaaatttg aaagattgtt agagaaaacc 83280
tcccatccag tggatgaatt ttttcataga ctttttgata gcagaaaatc ctcccacttc 83340
tgcttcagtt cctctctgtt caggatgtaa atgtaagggt tatgaggtct atgcacatgt 83400
gtttctgtat cagaagttac agttgtgcaa agcttcaaca ctggcttttt ctccacagat 83460
tgctagtgca actactgctc catcgatccc ttcacatttg tctcctggtt tacgagatgt 83520
ggctcttcgt tgtttagaac ttcaacctca ggacagacct ccatcaagag agctactgaa 83580
gcatccagtc tttcgtacta catggtagcc aattatgcag atcaactaca gtagaaacag 83640
gatgctcaac aagagaaaaa aaacttgtgg ggaaccacat tgatattcta ctggccatga 83700
tgccactgaa cagctatgaa cgaggccagt ggggaaccct tacctaagta tgtgattgac 83760
aaatcatgat ctgtacctaa gctcagtatg caaaagccca aactagtgca gaaactgtaa 83820
actgtgcctt tcaaagaact ggccctaggt gaacaggaaa acaatgaagt ttgcatgact 83880
aaattgcaga agcataattt tatttttttg gagcactttt tcagcaatat tagcggctga 83940
ggggctcagg atctatttta atatttcaat tattcttcca tttcatatag tgatcacaag 84000
cagggggttc tgcaattccg ttcaaatttt ttgtcactgg ctataaaatc agtatctgcc 84060
tcttttaggt cagagtatgc tatgagtagc aatacataca tatattttta aaagttgata 84120
cttctttatg acccacagtt gacctttatt ttcttaaata ccagggcagt tgtggctcat 84180
tgtgcatttt actgttggcc cattcatttc gtttttggaa attatggttt tgtattttca 84240
tgtttattta cattcatttt tgtttattca gggaaagctg atcttttttt caaaccagaa 84300
aaaaaaaatg aactagatat gaagtagagt tcattaaata tcttgctatt gtcagagttt 84360
ttaaaatata gacttaattt tgttttttta aattggaata caataaagta ctacctacat 84420
ttgagtcagt caccactctt attgtgcagg ttaagtacaa gttaactaaa aataaactgt 84480
cctctctggt gcaactcaca accaagatca agattacctt aaaatttatt tgaatttttt 84540
agatgttttg gttgtcaaac tgtaggaaac ttcacaacat ttaagtctta ctctgtatgt 84600
aacaatccat cattcacctt cactactggt agtaacatag agctgccatt ttccttttac 84660
catgcatcat ctctttacag taggcctggc agatcatttt ttaaaaagat tattcaacta 84720
ccaatcagta atgtttttaa acagtacatt tgctttgaac ttggaaaatg tgttcagaaa 84780
gaaaaatgga attgaatttc atttatacac taattccttg gattttgcac agttacctaa 84840
cggttttagt ctggagttaa attcagatgc atggaatcct gaaggaaaat ggtagctttt 84900
taatcttttt gtgtgtgtgt gagtctttta aatcaagtac tgattaacta ttaagtacaa 84960
ctttgagatt ttagttttaa ctcttcagaa gccagtgtga aatagaattg gttattctca 85020
aagactcagg ataaactaaa taagctatat atagagtaca tttaaaatgt acaacacaaa 85080
ttggaaataa aataagttac aagataagtt tacagggata tattgcttac aatttttaaa 85140
aggcagtttg ttttttatgt gaatatgttt cttagtgaaa ttttacattc ctttgttttg 85200
gaagattggc gatatttgaa gagttaaaaa tagtacagaa atgtgaagtt tggtatctct 85260
aaatgtgttg tacttgactt tcttttttat tttgtttttt tttttttttg actacttaga 85320
attttcacaa ttctaataag attgtttcca agtctctcat gtgcaagctt taaaggatgc 85380
actcttgcca ttttatgtac tggaagatca ttggtcagat gaatactgtg tctgacaaaa 85440
atgtaaactg tataaactga ggaacctcag ctaatcagta ttactttgta gatcaccatg 85500
cccaccacat ttcaaactca aactatctgt agatttcaaa atccattgtg tttgagtttg 85560
tttgcagttc cctcagcttg ctggtaattg tggtgttttg ttttttgttt tgttttcaat 85620
gcaaatgtga tgtaatattc ttattttctt tggatcaaag ctggactgga aattgtatcg 85680
tgtaattatt tttgtgttct taatgttatt tggtactcaa gttgtaaata acgtctacta 85740
ctgtttattc cagtttctac tacctcaggt gtcctataga tttttcttct accaaagttc 85800
actttcacaa tgaaattata tttgctgtgt gactatgatt cctaagattt ccagggctta 85860
agggctaact tctattagca ccttactgtg taagcaaatg ttacaaaaaa aaaaaaaaaa 85920
aatctctggg ttaagaaaat ttggcttaaa tgtatccttt gttattttaa atatattgag 85980
atattttaat taaaattttt accccattga accgatttta tagtatttgt acctattttg 86040
gtgtttttgt ctttatagta aataaaagtt tttgaacaaa tgttgttact tttatttatt 86100
ttgaaataat ttcatactta tataaaagtt gcaagaatac cacagagaac ttctgtatac 86160
ccttcaccca aagaccccag tcaggtttca ccagctgccc atttatgtcc tttatagcaa 86220
gaggatccaa accaggatca catgttgctc tcagttgtca tgtttcttca gtctcattga 86280
atccagggcc attccttagt tcttccttga ccttaatggc cttaattttt taaagatttc 86340
agattattgt tttatagaag ctcttcaaat tgagtttgtc tggtgctgct tcttgattag 86400
attcagagta tgcacttttg gcaggaacat cacagaggtg atgctgtgct cctctcggtg 86460
tgtcatgtca ggaggcatag aggtcgtttg ccccatcact ggtgataact gatagtaaca 86520
ctgtatagtt agtctttcct tttataatta aaatccacct ttataattgg aagtattctt 86580
tgggggtgat attagagact acataaatat gatgtttctt gcccagtttt aactctgctc 86640
ttagcttttt tgcctgaata tattactctg atggttgcca aatggtgatg tagttccttc 86700
actttttctt tgcaacattt tgctgcaaag aagagctttc ccttctccca tttatttatc 86760
atgtatcatc atatatttgc tcaacttgtt gcggatttgc ccagtgggaa tgtctgagag 86820
ctagcttctc tatccttggc aagccaccat tattctttga acacttccat actttcagcc 86880
ccatcttacg caatgtctcc tttggccctg gaatcagcca ttttcccaaa gagccctgat 86940
tcctttgata gagaatggta tgtttaaaac caacatctgg gtgctagata ggctcaattc 87000
tactggatgt caccactcct tggctgtctt ggtagagcta gaatgtattt atgaatatgc 87060
acagttcggt gcacacttgc aaagtacgca tacatatacc tacctacata cataaaaacc 87120
atgagctcac accaaccttc caactgcaat ccaacaccaa cagggttcat tcaagctttc 87180
cctttttcca aatttgtaac tttcttctca ggcagtgaga atcatgactg attattccca 87240
acatattgac ttacttgctt aattcttcct catgtccctc ccccatgtaa ccgatctcca 87300
tgcaaaatgg ttaatgttgc tgagttcaga agccattttg tttctctaca ttggtttcaa 87360
gtttctgtat aatttgattt gttgtttttt ttgttttttt tttttttttt ttttttgaga 87420
cagtctcact ctgttgtcca cgttgaagtg cagtggcaca atctcagctc actaaaggct 87480
ctgcctccca ggttcaaagg atgctcctgc ctcagcctcc cgagtagctg ggattacagg 87540
tggacaccac catgcctgtc taattcttgt atttttagta gagacaaggt ttcaccatgt 87600
tggccaggct ggtctcgaat tcctgacctc aggtgaacca cctgcctcgg cctcccaaag 87660
tataatttga ttttaaatgt aagtctttta aataggtttt gggtattttt tgcaaaaggg 87720
tacatttctg tcacttaaaa atattaagtt ggagaaaagt tttttttcca gatgaagtaa 87780
tagaaccaat tctattgctc cttaattcta tttaaatgat attaataatt ttataaaatg 87840
ggtgacagtc ttcatgtcag aatccagaaa aatgttgggg tattgtgctc atagaaatgc 87900
caatgattgc atttatgagc tgatgtaagt catttgttat aaaacaatgc atgaaataac 87960
tacagtgagg gaaaactgac taatggaaac ttatacaaat tgctgtcttt ctatgtcatg 88020
acgtggtttg gccgttttaa attatactat aagcataaat gccaggttga gctgtgatta 88080
<210> 5
<211> 98571
<212> DNA
<213> 智人
<400> 5
tttcgccctg ttgcccaggt tggtctcaaa ctgctgggct caagtgatcc acccacctca 60
gcctcccaaa gtgctgggat tacaggcgtg agccaacaca cctggctgaa aatagtcttt 120
tacgaatttc aaagctttga tttctccata agtgcactcc tggtaacttg agaacattac 180
acatttgtct cctttctgtg gccagaattg ttttgtattt caagtatgga aaggagcttt 240
gccagaatcc tcccgtgcta agtgtaagta gagcagttag actttaacat ggttgtgtga 300
tagtaatgac attcatatct gactctaggc aaggcatggc tggaatgaaa aacattgact 360
gttaagtgtt ttaaggtgaa cttctcagat actagatctc ttagctcaca tagtggaatt 420
ttgaggaaag tacagggttt gctcttcatc tcctaagaaa tgcaatgatg attctttaaa 480
gtactgatgg gtcagggagg ggagaaaacc attaaccgag aattgtataa tcagctaaaa 540
tattttgcag aaatgaaggc aaaagtaaaa tattctcaaa tgaaggaaaa tgaagggaat 600
ttgtcacaag cagactttct ctaaaaagaa tgttaaaatt cttcaggata aagggaaatt 660
ataccagaag gaaaaatgga ttttcaggaa tgaagcaaaa cataaatgta aatggatacg 720
taaatataaa agattatttt tcctcttgag ttctatatga ctgttgaaag caaaaattat 780
aaaaacatct gatggggctt ccatatatat aaatgtaata catatgccaa ctaatgacat 840
aaaggtcagg gagtggggta ggagacagtg gtaaatctac acggttgcaa ggcttctttc 900
tacattttac ttgaagtggt gtaatagtaa tactaagtag accgcaaaac tttaggtatg 960
tatattataa tccatagaat taccaaaaaa ttaccaagaa atatattaaa actacaatat 1020
agaaattaaa atggaatatt aaaaattttt caaataatcc acaagaaagc aggaaagtag 1080
aaacataaaa acaaaagtat agaggaaaaa cagaaaacaa ataataaaat ggcaagccta 1140
aatccatata attacattaa atgtaaatta aacacagcaa ttaaaacaca gaaattgtca 1200
gattggaatt tttaaaaaga gatctaatac gtgttgtcta cgagtaactc actttaaata 1260
taaaaataga tataaaaaag atgggaaaaa ataccatgga aaaattaatc aaaaaaagct 1320
ggactggctg tattaatatc agacaaagta gatttcagaa caaagatatt actaggaata 1380
aagagagata gtacagattg attaaaaaga gtcaatgtat caaaacacaa gagttctaaa 1440
tgtgtataca tctaacaaca aagcttcaaa acacacaaag taaaaataca cagaagtgaa 1500
atgagaaata aagaaatcca caattatatt ttgaaacatc aatgctaaca aaatcatcaa 1560
cttggtaaga aactacattc tgcccaacaa tagcaaacaa aatattcttt cataagtgca 1620
catgggacat tcaccaagat attctggggc aacacaaatc ttaacttgaa aagaactgaa 1680
atcttaaaag tacgtgtgtg tatgtgtgtg tgggtgtatg gttttttttt ttttaagatg 1740
gagtctcggt caggcgtggt ggctcacacc tgtaatctca gcactttggg aggccaaggc 1800
gggcggatca tgaggtcagg agttcaagac cagcctgacc aatatggtga aaccccgtct 1860
ctactaaaaa tacaaaaatt agccgggcgt ggtggcacgt gcctgtagtc ccagctactc 1920
ggaaggctga ggcaggagaa tcacttgaac ctgggaggca gaggttgcag tgagccaaga 1980
tcgcgccact gcactccagc ctgggtgaca gagcgagact ccatctcaaa aaaaaaaaaa 2040
aaaaaaaaaa aacagtgcta catggtaact catatcgtta tctcttggtg tgtttttatt 2100
gtttgacttg gcaattttat acatctaaag tatactgcta cataatcaac ttgactctta 2160
tttacaaagg acttcaaagc ttagtagtga cttaagcgct attagagaat gtttcggtgc 2220
atatttgagt atcagttatg attttcaatg gaaataaacc caaaaggcaa gtaactgtca 2280
ttataattct gattattaga atagaacaat agctacatac tggacatttc acctcccgtc 2340
tttagaaccc ttaggatgca attatttaat tttgaagtat accatttttt gtttcattta 2400
cagcctgaga atcattattt ttttaaaacc ttctttcagc tcctaatcct tgagtgatga 2460
gtttggtcat atagatgctt atatcataca gatattttta tatcatatag atattttaaa 2520
cactgaataa cattgcaaaa acctttgaaa gcaagatgac acctaagacc aatggcttac 2580
atataaggca aacattatca accgtgaatt gaatagtaaa tgctactcct gtaccaatga 2640
atggtgtcat gcattcaagt accaggtatg gctttttctg ctatgacaca caacttctta 2700
ggggcagata atcacataac aaaaaacata ttatgtaatt agcattttct tattaaaaaa 2760
taaattttag gctgggcatg tcggctgaag tctgtaatcc caacactttg ggaggccgag 2820
gtagatgaat ctcttgagcc caggagttgg agaccagtct gggcaacgaa gcaagaccct 2880
gtctttacaa aaaataaaac atttttaaaa atcacaaata ggccaggtgc ggtggcttac 2940
gcctgtaatc ctagcactct gggaagtcga ggggggtgga tcacctgaag tcagaagttt 3000
gagaccagcc tgaccaacat ggtgaaaccc cgtctctact aagaaataca aaaattagct 3060
ggcatgttgg ctggtgcctg taatcccagc tactcgggag gctgaggcag aagaatcgct 3120
tgaacccggg aggcagaggc tgcagtgagc cgagactgca ccgctgaact ccagcctggg 3180
ctacagagtg agactctggc tcaaaaaaat aataataata aataaataat aaattttata 3240
aggaaaaata tccctagtat atttttcccc accaaggtct acctattaat atctcatata 3300
actctgtgct tgaaacacaa tttgggatat attgccttaa aatttacttt gactagcaat 3360
tcagtgttcc ttttttaaaa aaatctgtac tctggagtaa cagtgttcta aaactgttga 3420
agaacattgg ttcgagaaaa acatttagaa acacaaaccc ctggaatgtg agatgaaaat 3480
ccgagctaaa gggagaaaaa ggacgaaaga aagaaaacac agaaaagaaa gaaatacagt 3540
caagtgaaac tacgaccaca aagaggaaca gatccatctc atttaccatt ggggtatgga 3600
cggacgtgcg gtgttcgaga agactgttat tggtcagagt tttgctctag aggacaagta 3660
ggactgtaac atctctagga tgggtcactt cccaagccct ctattactta aaaattcaag 3720
gaggaaccga tgctggagta cttgtatctc agacttctaa tcactgctcc tacgcttttc 3780
caatattaca acaaaagacc agtaggggga gaaaaacgca cagtaccgaa cccttatcag 3840
tagtaatctc aaaagtcaac agattgattt actctcaagc aaacagactt ctaaggtacg 3900
cagcaccaag acactacctt gaatcaaatc tatagcctat atgacatttc tgaagtctct 3960
gttggcatta cgcgaaaaat cccccacgtc ttctgaatag ttagaattga atcctacaag 4020
ctgcttcgaa tcagaattcg atttaaaaaa aaaaatgagg gcatagcaaa aggtctccac 4080
gaagtgagtc aaaggactgc agagggctgt gacagtgcat tccgccttcg ggatggtata 4140
caacttaaac catgtcggca gaagaacgca cagcaacgct ttgtaaaaag cattctttct 4200
attatagaat ccataaccac gctggttagc cactgacagc ggcggttagc caccgcacct 4260
cctctcaccc ccgaactaat ctcgtttcct ctatgggtgt aaaagtgaaa taacccactt 4320
gctcccaata ttcctttcta tatctctacc ccagctcgcc tgctgctcgt agaaacaaat 4380
atactacacg tacgctgtcc taggatgaca caacaccctc actactgcag aagacggatc 4440
attaaacaaa cgtcagaaga gcagccccaa ctgtacataa acttcgggcg gaaaagcaag 4500
acgcaggcgc agtagcacat attgttaccc tatttgccca ctccctgctc ctcctcgcct 4560
caatttcgct tccgcttctt tgcgcatctg cttccggggg attgtaggct ctgcccctcc 4620
tcagctctta ccctcttctg ccggaggagg gggggggccg agggggtggg gaagagttcg 4680
ttgtttgttt acacgatgtg agcggaaaaa gagaccaata aagtttattc tggaaacaaa 4740
aggaaaaaaa aacaggggcg acggagaaag gagtcggggg cgggggcgtg tggcgggggc 4800
tagcgaggag agggagcgag aagtagaaag cggcagttcc ggtgccgccg ctgcggccgc 4860
tgaggtgtcg ggctgctgct gccgcggccg ctgggactgg ggctggggcc gccggcgagg 4920
cagggctcgg gcccggccgg gcagctccgg agcggcgggg gagaggggcc gggaggcggg 4980
ggccgtgccg cccgctctcc tctccctcgg cgccgccgcc gccgcccgcg gggctgggac 5040
ccgatgcggt tagagccgcg gagcctggaa gagccccgag cgtgagtaga gcgcggactg 5100
gccggtagcg ggtgcggtgg gaatggggac cgggtgggtg ccggagactc ccgggcgcgc 5160
ccgccgtgtt gggcggaggc tacgggctgg tcgtctccca gcgtcggccc gcggcggagt 5220
tcgcctgcga tcgccgcacc ctctccctcg cctgcctctg gcctctccta gctgcagagg 5280
cgagggctcg ccgctccctc tcctttctct ctggctgccg cctcgctctt cctttgcttc 5340
tactcccagt tttggggacg gggcggctgg aggttgagga agtgcgccca gggccgccgc 5400
cccggccgcg gtggctctgt ctcccgcgcc ctgcacgccc acccagcccg cgggtggagg 5460
ggctgccgcg aggactgcgg ctcaagggac gcgggcgcga aaccgcgagc ttttcttgag 5520
gggctgtcac gcccgaggac tccggccccg ccagcctggc ggccctgcgt ttgcctctta 5580
ctgggtttaa atcgcccggc aggggtatgg aaggaacacc gctcccctca cccccgccag 5640
ctcccctccc acccttcctt tcgaggttgt tttttccttt tagctgagac aaacgcttag 5700
atctttcatt catagacctg agacactgac tcatgtgact tgtctcttta ctaagtgtat 5760
tatgtgatgc ctgttccatg gctcttaagt ggctcggaaa ggtagggtag ggcccgggat 5820
tgggctatgt aaacaccaga cgttcagccg gcgtgttttt gacctcggct cgaggggttt 5880
attttaggat gctaaaggaa tagtgatggt ggccaaccgt gttaccagac ttgggaatcg 5940
aaagctattt ttttatgtca ataattgaga ctgtttacat ggttaaataa agggtagggt 6000
aaagggagcg caacaagagg gtctttctag aaaacagtct gcatattctt taatgaatta 6060
gagttgtgat ttcatcttgg tgaagcttcc tcattccagc actgcgcctt tgtgcacatg 6120
caggacctgg gttttcggaa cgatgttttg aatcatagtt tgtgtggccg gggagaaccc 6180
cttagaatac ttgggtaggt aaattccagg ttatctcagg ggattatttc tactgcgact 6240
tttgaaccac tgagggcaat attggtcata tgttatcctg cttagaaatt gaatttttct 6300
gagtatttgc ttacattgca ccgtacaaaa tttgtttatg tgctggattg cgtgttttaa 6360
gaaaacttct ggaaaatact caaaataccg tgttgctaag ttagtttgga taaatcaaaa 6420
cactttgctt tcaaagcaac tacagtctta acaatttaac gtgtctttgt attcaggttt 6480
taagtttttg gtgttttttt tttttccttt taactgaagc actgaggtcc gattgacagc 6540
atagatctcc atctaaacat cacatgttct ggaaattttt aattatcaga ttaactgttc 6600
tgcagtgtca tcagccaaaa ttatctgaag aggactgtgt gtgtttacgt gtgtgtgtgt 6660
gtgtgtgtgt gtgtgtgtgt tggtattttg cttaagtttt ttcatctcac attttgggac 6720
aaaataaaac ttcatagctt ttttcaaaag tttcttgtgc tttttcaaac tagagtactt 6780
tcctattaaa atcacaaaat agtttattta aaaatgatag catatcgtaa taatagcatc 6840
atgggggaaa taacaagaaa gtaaaggaat attaatattg catgattgtg cgtataaagt 6900
tttaaagaca ttcctgtcag ttttaaataa ttaaaaatga aacacctgta aatatagaag 6960
agtgttttta tttaaggtta aaaaaattta actaaattgg ttatagcatt aaagagatgt 7020
tactaaatac aaatattgta cttaaactga aaaatggctt catggaagtg taaattgtca 7080
tgggccttga tatatttaaa agggagacta aaagtgcagt ggttttgctt gctctgtgcg 7140
tggaacagcc tttctggtgg cagagcttcc ttcctgtcag gataaggtcc tctccatccc 7200
aaatcagtat ccccttaaaa aaccaaagaa aaaacccaaa cttataaata atgcacaaca 7260
taaagtagac tgtaataact ttttctctaa accagtttac tttgtgtgcc gcttcttata 7320
agtacccttt actgaataaa gagttttaaa cagttacgat taccatttaa agggcacttg 7380
ctctgttgat ctgtttattt gaagagaggt aacttaatcc catttgatct cttgagcagc 7440
tacagtagca ttaaaaggat cagttctcta ttttgttatt ttatatcttg aattccaaga 7500
taggggtgat tctttaaatg aagtgtttct taagcattat aaaatatttc atctccagtg 7560
aaagtattta caatcttaaa aattattcag ctttagaagt atatgtctta gaatatcatg 7620
gtttacattt tattagcaca gttatcaaat agtttttctt aagtattacc ttgagctata 7680
ttaacagtgc cgtagacaga gtggtattac tatccctaag aaatggtatt ctaatctgaa 7740
gtcagttggc aggtgacaga ctcattgaca aaaccaacat tttccgactc ctttcactgt 7800
atcatgctgc gtctaatctc cagcctgttt tttaatagaa ctgaagaaat tagggcccaa 7860
ggaggcttaa ttactgaaga tctccatttc ctatatttgc agtaatatct ttatttaatt 7920
tcctttacat catgaacagt ggttttcaat cctggctaca cattagaata atctagggag 7980
ctttttaaaa gtactctggt ctcatcccca gagatgctca tttaattggt ctgagatgga 8040
tcccagttat ctgtgttttg ttttgtttgt tttgaagttc accaggaaat gctaatagaa 8100
aaggatgtaa agccctggct gtcaaggacc tgtatatttg gtccttgctt ctttctctag 8160
gtttatttct cctccctact cctgcagctc ccttggtctt ttcatactct cctgtgcaaa 8220
tacagtttgt acttcctgag acatttgaac actccattct tctttaactg gttgactcct 8280
actcatcttt cacatcacct cctttgaaaa gtctagcttg agttaggtat ccctgcttcc 8340
tgttcccata gcatcgtgta ctcccactgt catagcatta acctcactgc attgtaattg 8400
cctatttctt tgtccatatc ctctaccagg ctgtaaattc catgaggata gggactccta 8460
tcttatatac tgtacagtag tattcttatt gccaagcaca gtagcctgta cattacagca 8520
cttgactaaa caaataaata tagtagagac agacttcttt aaaacatgta gtgattcata 8580
agcaccagtt tttattcttg ccaatttcat ttaatatttt tggtcactaa aaatgtacaa 8640
ccctgaaatt gccacacata cgaatttcat ttggggacag ttgagatgtt ataaattgta 8700
tagagtggca ttccacctca gacatataca cacacacgca aaaaatgaag attattatca 8760
tatatagtac tgcactggaa ataaggagac ttgaattctt acccctgttt caccacaaac 8820
atttgggcac gtctcaatct ctttgggtgt catgtataat acagagggat tgtacgaggt 8880
gctctacatg gttctcagtg atctagcctt aaaattctgt gagtatcaac agtattggct 8940
ttggaatttg aggcaccatg gttcaaaacc tagttcttaa acttactggc aggattactt 9000
tggacagatt ttcttatctg taatgggggt gattactatt caacagagtt gttgaattaa 9060
atgagataat gtagatccaa gagagttctt gccctggatc aggtgcttaa taaatgttca 9120
tttcctttct ccttaggaag tgttagatct catgagtgga cttatctgag ataacagaag 9180
gacacagttt atgtaataaa tcctattttc cactttgctg actgttagca ctgcaggtgt 9240
gattagggac caaaaaacac tgtgacattt ggtttcagtc tctcagaacc ccattccact 9300
gtcaaacacc caggtgttag tcaacctgct tgggaaataa ttatgcctgg aagtttcaac 9360
caagagagaa tagcaagtgc caaactattc acacatatat aataatatgc aggagggtac 9420
agtctaaact gatgaactta cactgtctcc aaagataagt aaaatcagac ttcatcattc 9480
taaaaaaagg aaacaaaatt aaggatgatt tataaaagaa aatccaaaga ttttggtgaa 9540
gtctctgttc accaaacctt aaaattcagg agccattatt tagtaatttt caggtgatat 9600
aagaaatata ggaaaaattg gtcttctggt caggactaat tccagaacat aggcacaaat 9660
aatgttttca atttcagatt agcggttaca gatatcagca gactgaagtt attgatacct 9720
ttctctactt gggaactgtg ttttaaaatt taatattgtg ttatatatat cacctttatt 9780
tatttggtaa tattgaaagt aaacttacac agaatgtaat acaggttgga catccctaat 9840
ctgaaaattt gaaattttat atgctccaaa atctgaaact tcttgagtgc caacatacgg 9900
ccataagtgg aaaattctac acctggcatg tttgctttct ggtggtcaaa ggtacacaaa 9960
ctttgtttca tgcatataat tatttaaaat actgtattaa attaccttca acctgtgtgt 10020
ataaggtgta tgtgaaacat aaatgaattt tatgtttaga cttgggtccc tagtatgtct 10080
cattatgtat atgcaaatat tccaaaatct gaaatctgaa atctccagtg ttttggataa 10140
gggatactca aaacattgct ctgcagaagt ttcttgttac cagtcttatt tttgtataaa 10200
tcaaatttgc ttgcctgagt tttcctttaa gtttatgtga aagtgaattt tataagtaac 10260
ttattcgaaa gaaatactgt aataaaaatt aaaaactgtg gatgggggaa actgaagtgt 10320
taggatataa aagataaata tgaggcaata tatagttaaa gtctgaggat tcagcttcaa 10380
ggctagagat ttccatcatt caaaaagatt attcagctat tggatatact aatattttat 10440
cactgtatac cttattcaca tttaattatt atgtgaatca gttgatcctg gttaaggact 10500
ttttaggtgt tctttctttc cctctctacc tatacagttt agggagtttt aagttaaaat 10560
attccaataa aaagtttgta agtttgtaat aaaagtggtg gcttagagct atctttttct 10620
tcaaatagtt cttaaagtga aactgtgtct aatacgtatt agagagctct ggtttagatg 10680
cctaaaacgg gtcctcctgg ccagcagacc cagtacctgt ccctggcctg ttaggaaccg 10740
ggctgcacag ctggaggtga gcagtggggc cagcattacc acatgtgctc tgcctgttgt 10800
cggagcagca gcggcactag attctcatag aaggaccaac cctattgtga actgcacatg 10860
caagggatct aggttgcctg ctcctaatga gaatctaatg cctgatgatc tgaggtggaa 10920
cagtttcatc cccaaaccat cgcccccaca cttccccaat ccatggaaaa attgtcttcc 10980
acgaaactgc tccctggtgc caaaaaagtt ggggaccact ggcctaaggg actaaattcc 11040
ccttcggact gctactttgt atatgtatat ggtgggggac agattgtaac acatttttgt 11100
gtctttttct atattgatac aataggaatt gtaatgtgtt gcttgctaag taacataatg 11160
agataattca aataatcaca agttgcataa aactaggaaa aaatgtgcac atactaatta 11220
ttattttaaa tttatattta acagaagcat aatattttat atttggcctg acaatgtact 11280
catttctcaa gcatcacttt ggtagttagc ttgataattt aaattgtact catttataag 11340
aggttgtgtt ttagcaactt ttgtacatta ttgcgattgt tacaaagggg tctttatgat 11400
ggctagcatt gccatttgaa ataaattagg gatttttaaa aatctataag aattcttaca 11460
gactatgctt gtcaggtaca cttcggattt taagtatttg tatagtaaag ccaaggaaat 11520
cagtgttgtg atgtgaagaa aaaaactgta tagggataga atcattttgc tctaatcata 11580
actctcctaa ctcaccagga gttagcaagg cttagtggac gaatatgtct tataagtaca 11640
acaaaaatat aaggcactat tatgaagagg attttaggca tatgtttttg aacaggagga 11700
gacaatgttg tgtttattgt atcctcagca catactgtag tgtccaaatg taggtgatca 11760
gtaagcactg atctttgtga catagaatca tatttagaaa taaaaatact ttcttatatt 11820
tctatcagga gccatacgct ttatctgaaa agcaggtaaa ttgctgtgtg ccagtcttat 11880
ttgatcattt attgagcaca gatttggccc tttgtattcg tgggttttgc ctccatgggt 11940
tccacttacc atggattgaa aatattagga aaaaaaagga tagttatttc tgtactatgc 12000
atatacagat tttttttggt cattattccc taaacaaaac agtagaacaa ctatttacat 12060
aacatttaca ttgtattaag tattaaaagt aatctagaga tgatttaaaa tatacaggag 12120
taggttatat gcatctgcta ccccatttta tataagggac ttgaacctct atggattctg 12180
gtatccacag gggtcctaga cccaatctcc aattttccat agataccaag ggataactgt 12240
atataagaaa cacttttgta taagttatta actagttgcc tatttctatt gatatttgga 12300
gacattttgg caaagattgt taggttacag agaggctgtg tgctgtggtg aaaaaaaatt 12360
cgatcacgaa tcagaaaaca cggtttttcc attcatctat taactagctg tttggcctaa 12420
gatcttggcc tttcagagct tgtttcttca cctgcaaaat ttctaataca actcccaaat 12480
gctgagattc ctagtatgtt aaagcctgtt tttttatttc agggaagagt aagtaaatca 12540
ctccctagag agaagacagt ctagctcagt ttgttgtatt ttcagaagct aagatcattt 12600
tgtctgcctg tttataaatt tgcacatatt ttaaaggtcc ttgtgtgaaa ttctgtggca 12660
gagaaaagct gccattggaa aagaatggag tggaaggatt ttcccccctt ttttgaaacc 12720
gttagtgact ttggagaata aattgctaca ggtgtggtca aaattttggt tactggcact 12780
gggagcaatt aaatgactgc cagacattga gagtaggtca tctactgcac accagttgcc 12840
agggttataa aggccagcag acttgtcaca gcacccttaa tagccactgg ccatcatcct 12900
tacttgttaa agacttctag gaaagtatat tccatatttc ccttggtaac tcatccctct 12960
aggtggtttt cagaaaatgt gttctaatct tagaaacata aatctgtagg catggtaagc 13020
ctcttttttc taggtctatc ctcagttgtg cagataagta tgtggaaaga taacagaaat 13080
cattgtattt gatcagaaag cagtgatgtt tatgctattg atttattgtt tttttctgtt 13140
aatattcaaa ttaccttcaa cttttgaata ttttttaacc agcacactgc tcaggtaatg 13200
agatattatt tagagttatt ttgaggatgt actcattttt caacaagcta agcatatttc 13260
tgcagcttgt ttttctttga gagttcttgc ttttccaagt tctttttcct gatggactta 13320
tggcaggtct agacctgaaa gtactattgt atttcaaaac aactgactgc ctttagcccc 13380
acagtgactg aactgtattt ttttcttagg aggttaatgt ctttggcaag ctaaacatcc 13440
ttggaatttt ttgctaagtc agccactatt ttgtgaatat agatttatgg agtatatcat 13500
caaattcaaa gcagcattaa tgggaaaatt tgcggaaaaa atattgaaat tagacactac 13560
ttacaaactc caatctgaaa tgaaaccata catgacagca gggaaaggaa agaattacat 13620
tttggaaccc taacttttat gcatataaat atcaatgcat agtaatgtca ttttaaagtt 13680
atatgccttc tgaagctttt cttaaaatct aatggctact attatttgca gttgagacca 13740
tgataggcag catcttatgg tatttatgaa agtgatattt gtgttctttt ttctaactat 13800
ataccaattg taaaagttga acatgacttt ttcaaagcag tttctatact tgataataac 13860
agtggtagta aaactcagaa cagtttaaaa tattagtaat tttacagtgt agagactttt 13920
cttcactaga aatgaccagc tttcagattt cttagtgata ttatgagact ctagatttct 13980
tcaaaatcat tttgagtaaa tctaccagtg tataactgct aaagcacagt taaatgtatc 14040
atgctgtggt cttttttgtt tgtttgtttg gtataaatat cagacatata tgtttgttta 14100
ctctaaaact aatttttttt accaatcaaa attgaggcac gtaatctgac aatgggacag 14160
gatatttgca gtcaggatag tcttagaaaa gccacaaaat atggtcgatg tacttagact 14220
tctttaattt tccttgcctt ttcctaaata tatctcataa tgattaagag catgttctct 14280
agagtcagac tatcgagatt actagttttg taactttggg aaagttattt aacctgctaa 14340
atattctccg ggtaatacgt atttcttcat ttgtaaatga ggggtaataa ctacctacat 14400
cacaatgttg taatgaggat taaataaata atacttgaaa gcatttagta aagtgtgttg 14460
tacatagtaa gcactcagta agtatctgtg aactccttga gagtaagaac catgttacat 14520
tcatccattt atttgggtgc tttaacatta tgaagtgaat tgaattctgt cccttccaag 14580
aatttaccag tggatccgat ttctggatag tgggcaataa ggttgccttc aaacaagttt 14640
agagtagttt tcagttcttt acaatactgc ttgcttttta ttcgttaaaa cttttaaaat 14700
ttcattctag ctctaggaat ctgaatgcta tttcatacct actcctaagg gaagttagca 14760
tatggatatt tagtttaata ggaatgagga attaatggac agaaggtatt aagtaagtga 14820
atgtacaatt ttcacatcta gtctgtgctt cctgtggatt gattttccct gtccattcct 14880
ggaatcttcg aattcccagc acttatctta atagcactct accattgaag cagttttgtt 14940
ttgtgctgtt agatacttcc tttccctgtc ttgtcttttt ttcatgcact aaagacaaga 15000
gttgtgtcgt attgtcacat agtccttata ttacagggct tttaaagaaa tctcacgtcc 15060
tgttttcaag ctgcttgtat cttgtttgtc cattctactt gctatgaagt ctttattgaa 15120
tataatatta aactcttttg catatcattg tttgttacct aggacactca atggacatgt 15180
gtaaacttta caagtcattt atgtaaaaat aaggaaagca accatgtgtt ttaattattt 15240
ccatcagttc aatctctaag tctttgcctt taattaccaa acagctatgt ggtgccactg 15300
atacgagttt ctgtggtatc ggctacctgg ttttagtact gttgttacta ctttatgtaa 15360
atgagactat tcactcatat ttaagtttgt ggaaaatgta tatatgttct tgcgttttag 15420
cagttttggc tagactgctc ttgatggtca tgcagggtaa cttacttttc taaagttgat 15480
gatttcatgg tctgtatttc tcatatacca ggataatagt aaaatctaca cactttaaaa 15540
aactacatat gttgttgtta acatatatgg aggtttcttc agaaattatc tgcgattttt 15600
gttgtaattg ttttcattgt tgtgtgcttt taaagaatga cttttattaa gcatgcttcc 15660
aagctttttt gtacatgaaa aactgcatat aattttgtct cttttagggg gtgatatgta 15720
caatgaaaaa ataacatgac attggattgc cctggggctg accaagagtt tgtttccata 15780
gtaagggatt atgactaatt taggcattga agttaagaat ttattactta tttttaaatg 15840
acatcacgaa gagttacagc tgaaacccat ggaagaagtt ttcttgattt ttctatatgt 15900
acacacaaat gtgtattttg aattcccata aacccaaact ttaatataaa cctgaggagg 15960
gggagcatta tggactttgt atatgctgcc tcccttaatc ctcacaataa cacttctgat 16020
acatgtgtaa tcacttcatt tccatgatta ggaaaatgaa gtcccacatc aaattaatac 16080
agtagaatct cacctcattt attttacatg aaatcaactg tacctactca gtcaaacata 16140
aaaacgtgac aaaaataata cagtcatgtg tagctttaca gtggcaatat gttgtgagaa 16200
atgcatcatt agatgatttc atcattgtgc agacaccaca gagtgtaccg acacaaactt 16260
agatggtata gcttactaaa cacctatgct atctggtaca gcctgttact cctgggctac 16320
aaacctgtac agtatattac tatactgaat accataggaa aatgtaacac agtggtattt 16380
gtatatataa atatatctaa acatagaaaa ggtacagtaa aatacggtgt aaaaaatttt 16440
aaaaatggta tgcatgtata aagccttacc gtaagtgaag cttgcaagac tagaagttac 16500
tctgggtgag ttggtgagtg agtggtgagt gaatgtgaag gcccacgaca ttactacaca 16560
ctaccgtaga cttgatgaac actgcaccct taggctacac tagatttttt aaaaagtaaa 16620
gtaattgcgc tacaatgtta tgacagctat gatgtcacta aatgatgaga gtttgtcagc 16680
tccattaatc ttacgggatc actgttgtat atgtagtcca cagttgacca gaacattgtt 16740
atgtagcaca taactaatgt aaatattgca aatcacatct gactactgag cttttgcttc 16800
aaagtagaca cttaaagata agaatttgcc atcctttcag ttggtctcag tgcctaggtc 16860
taggtatgtt acattttgtt gtgttgagtg tgattctgtt attcagacat gtaatgttca 16920
tacaacatgg cctctaatac ccagcctgta gtgcccaacc aaagaaacag cagtttgatc 16980
cggtgctgga agagaaactg ctgtttgggc ttgctgagca attgtattgg tctccaatgt 17040
ggcctgcaga tatggcaaca agaaactgtc atgtattctc tttgatatac acacgtgtgc 17100
accccacatg taagccttca cccttcttaa ttctatgtat attttatata ttgtgtatat 17160
agttctattg ttttagattg ctatatgtgc attatatctt tgtacaacac acaattttgt 17220
acagtgtggt atacaaaaac cacatacatt atactttatg gatgacttga gatttttcaa 17280
gaaaaatgtc gattctgtac aatcatagac tctgtttgtt tgcacatact catttctaga 17340
acatggcacc ccagaaatac ctctttcagt tactagctac ttagtaccaa cttttcaggc 17400
tcacaaaaca gtagtttgtt caatgttaca tagtaggcaa attactatta tggttctgat 17460
ctagaattat aagcaaacgt gctgtttcat tgcatcagac cttcccttct tcctcggtgt 17520
aagagagatc aagtcttctt ggctcagtag caatgtcttc tgtccagcta gcaagaatgg 17580
cacaggaggc tcagggtaca cttctcatta caaggcctta agggaagtgc tgcttctcca 17640
cacagagcag ataggacaaa aattgggtgt ttgcacaaag ggagcaatga ttccataagg 17700
aggtgaaagt aacacataga tttgtcacct tatttacatt ttctatcttc ttgtctctag 17760
gcaaaggggg taacagaaac ctgcttagtg tttttataaa gtaaattctg cctagtatca 17820
ttgaatttcc tttagcacat ccatagacat acaacagaac agataggaga aagaaacata 17880
aataacagga agtgctgggc gtggtggctc acgcctgtaa ttccagcact ttgggaggcc 17940
gaggcgggca gatcacttga ggtcaggagt ttaagaccac cctggccaac atggcaaaac 18000
cccgtctcta ccaaaaatac aaaaaattag ctgggcgtgg tggcgcgtgc ctgtaatccc 18060
agctatcggg aggcttaggc agcagaatcg cttaaaccca ggagttggag gttgcggtga 18120
gctgagatca cgccactgca ctccagcctg ggtgacagaa tgagactctg tctcaaaaag 18180
tgataataat aaagagataa cagaaagtcc agtggtcaca ggaccagatg ttttgagatg 18240
cttgtaattc caaatgttcc atttccatac tgttctaata tgactcaagt aattcatctg 18300
gggaatgaaa cagatttttc aaaagcgcct tcagaatttg ggctgagaaa atatcactat 18360
atgtatattt atattttttt aaaaagctga gtgattaaac attatttcct gtttattcaa 18420
tataccctat aattgacaat gtggtagacc ctgggtatat aatggtaaac aacacaaaca 18480
tactctgtga ttgtacggtc aacgttttcc ttgaaaaatc tctttaatta ctcataaagt 18540
acaatgtata tagtttttat atatcacctt gtacagaaat atacatttta tctctgtata 18600
aaacatacag aaatctgaaa catgatgaag ttatatatgc aatgtatgca atacatgtat 18660
ttaaaagtgt gaatttatgt gtatatatat atgtatcaaa gagaatacac atgcacagat 18720
gatagtttgt tgtggccata ttaagccatc tttgcatttt aaggataatt tctacttgta 18780
gaaattatct acaagtagat aaacacatta tctaaacaca tgttgtagag tcacactctg 18840
ccacacccat ctaatttttc atatttttgg tagagacagg gtttcgccat gttgcccagg 18900
ctggtcttga actcctgggc tcgagcagtc tgcctacctc agtctcccaa agtgttggga 18960
ttacatgcct aagttagact taatatcata cccggcctgg tatgatagga tttcattcct 19020
aggaaaacca agagtcaact gagaaattgt tagaatgaat aagaattcta gagtaaatag 19080
atgtaaggca aatatttaaa aatcaatagt tcttccttat gatagcagta attgtttaga 19140
aaacgggaaa aaaacccatt tagaatagta acagaaaata taaaattata aatgagccaa 19200
tgtgaagaaa cctaaaaatc tacttggatg ttggaggtta cagggaaagg aatatcatgt 19260
ttctgaatgg gaagtccagc aattacagat accagttttc ctcattaaat tacaggttta 19320
gcctaattct cttctttaaa aaaaaaaaag tgagaaatta gcaaggtaat ttttaatttt 19380
gtctgagaaa ctataaacag ataaaagtaa ggtatctttt gagtggaaaa tgaaggacag 19440
agcgctaacc ctgtagctta ttagctatca aaatatacaa tacaattaga gtaaatgaaa 19500
gagttgaata ctggcataca cattgatagt aaaattggta aaagggaata gagatcccag 19560
aaacactcta aatatgataa agaagtaatc agaaattagg agaaaaagga aaactaagat 19620
ttgtttttga gagtattaaa tacttaggaa aatagacttt tgaatcttta tttcatctta 19680
cataccaaaa taaagtctag gtaagttgaa gagttaattg gaaaagagta aacttatgcc 19740
tagtgtcatt ttaaaaagac atttatgtga atggggaaat actttccaaa gcttcaagaa 19800
ttgtaagtac tcaaaaggag gaacaatcat tcgttcgact ctcaaataag attggggcat 19860
ggcaatgtgc cccctctagt ccaagctact caggagactg aggcaggaag actgcttgac 19920
ccccggagtt taaatgcagc ctgctagcaa gactccctat ctttaaaaaa acaaaaaaag 19980
aaaaaaatct ctttctctca cctcctctcc ccccaacccc catacaagtg aacaaattaa 20040
aagatgtgca gaccaggatt agagttctgc aaaaattcaa tagatgtttg tctttaaatt 20100
tttactacaa atactttcaa aagcaccatg acccatatgg atgaatgagc aaagaatttg 20160
agaagttggg ctcatttact aaagaggaaa tgcaggtaca agcataaggg acatgttttt 20220
ccctgacagg taattgaaga agtgaaattt taatatgtag tgattttttt ttttttactt 20280
tttgagttag cagaagtatt tttctaatga tgtttttgct ggtgagggtg ccatgcaatg 20340
tgcttgtcca tttatttcca ttgacagtct gaattggttt aaccctttcg aaaagcacgt 20400
gaacaatttg catgccttta aaatcaacat acagtttgac ccaataattc tctttgcagc 20460
attagatata ataatttaca acagcttatg tatttaacaa ctaaactgtt taacatctcc 20520
cgtggaaata ggttgtcata gaaaatgttt atgaagagtt tacaataatt tgcggaaatg 20580
tttttgtagt gaaaaaagat acaaaattat gtatactata tgagtacaag tatacaaaac 20640
tatagaaaac aaagaaataa accaaaaata tccagacaaa actgtaagag aatacataaa 20700
agatgctaat atggtgtctt aggtacgttt tcttttggtt tcatcattca tctgtgcacc 20760
gctatatttc cgatacttac agagcacaat cccaggccca taatagacct ttcagtcagt 20820
gcttaagtga ataaatttct gtaataaaca tgggattcat ttacattgaa agaaatatga 20880
atacactttc catccaagtt aagaaaagga aaaatgtggg aagcactcta gaaaggaaac 20940
tgattaatac cttacaatta gattttgttt tcagaatgtt ttcacatctc tattttatgc 21000
gatccttttc tgttctaatt taataatatc attacttacc taagttagaa atttgtgcta 21060
accggctggg cgtggtgcct catgcctgta atcccagcac tttgggaggc caaggcgggt 21120
ggataacctg aggtcaggag ttcaagacca agcctgacca acatggcaaa accccgtctc 21180
tactaaaaaa tataaaatta gccaggcatg gtggcgcata cctgtaattc cagctactca 21240
gaaggctgag gcagaagaat cacttgaacc caggaggcgg aggtagcagt gagccaagat 21300
tgcgccattg tactccagcc tgggcaacaa gagtgaaact ctgtcttaaa aaaaaaaaga 21360
aaaagaaaaa agaaatttct gctaaccttg attctatccc ttttgacctg ccaaatccaa 21420
ctgattacca aatcttgggt attctttctt agaaatgtct ctggatttta gccccatctt 21480
ttctcataat cactgcctta gtttattcct ttctcatttc actttactgt ccctacctgt 21540
ccttctacct ttctactctc ctcttttact ttccacactg ctgtaaaaat tgtcaggtaa 21600
atagcagaat tttgtgtgtg tgctattata aataggctgt atggaagaga ctggggggag 21660
attaacactg ctttcacact gctattacaa taatcaccct aaaatacaaa attgatctgc 21720
ttaaagctta gtaattcctt atgacctata ttgatgcttc tcaaacttgg gttgtataag 21780
atcacccagg agacttgata atgtgcaaat tatccagacc ctagaaattc tggttgagtg 21840
gatccatagt actgggaacc tgaattttat ttttatttta attttttgaa acaagagtct 21900
cactgtgaca cccaggctgg agtgcagtgg ctgatcataa ctcactgcag ccttgaactc 21960
ctgggcttaa gtagtcctcc cacctccacc tcccaaagcc ttaagattgc aggcatgagc 22020
cactgtgttg agcctggaac ctgaatttta ataaggcttc cctctcatga tccttacgca 22080
tatgatccca ggacaagatg ttgaagaaca gaccttggga taacatgcag tctcattaat 22140
ttactgtaat tctcacaatt tggcatcagc cttcttttct gtgctcattt tctacatttt 22200
tttctcatgg acaccttaca gtctagtcac tctgaactgc tacatgctca cctaggttat 22260
tgtggacccc tgttcttgtg ctcatgctgt tctgtggttc acagcctttt ttgctatggc 22320
ttctcctact cagtaacatg ttgatcttgg tacactatct tcagcttata tgtaatctga 22380
gtaaagtatt cccagactca ctctcctaga caaagtctat ctctccctct tctgtatttc 22440
catagcctct attacaacac acatatacta aattacactt cttttcatac cttcctcact 22500
agaccatgaa cctcttgaag tcagggatgc catattttag atcttttatt taatcttaga 22560
gtaaaagcct ggcacaaaat aattgcatgc taaatatttg tcaaatcatt aacaatccaa 22620
taaagaaggc aaggagtaat tagtcccatt ttcagtgagg aaaatgatat cttgagaaat 22680
taagtatttg cttttaatta cccagcttgt aagcgtaggc tcaagactta cacataagaa 22740
atctggcttc ttttctggtt ttggtcttta cagaaaagat agagaataac tgtaaaatta 22800
ccccttccat ttttacccac acggctcaca tgttcattta aattaccccc tccattttct 22860
acccataaag ctcacatatt agtttatgtt ttatcatttt atgggtaaag gtgttttaat 22920
aaacttttac atcatattca cactttataa aaataaaata atgcctattc ctctagggta 22980
tgaacagatt gctggatatt aagccatttg tctctcactt tcacatctaa ccttctttac 23040
tctgctttgt aatgcttatt tatttctctt gcagaaagca tgttatagtg ccttatggga 23100
tgtctacaaa tatttgttta atcaaattga gctaatattt atgtaggaaa cattttattc 23160
tgcaacaatt aaggcaaaca gatatatgtg tgtaagtatt cacatgggtt tccactgtag 23220
ttttgaaagc tcagtttcca aagtttagat gtgtttagcc ttactgtaga cttcactctt 23280
aaggtgttga tggaaatcaa caaccagctg caaaattcag atccagtatg ccataggata 23340
catgtagcca cggtttaaac caaatgttag caatgaaata tttagtagca actgttcttt 23400
taaaagaaac attttagata attagagtcg tcttgtaata tcttataccc agctgtcagc 23460
tttttacttt ttctgccaat atttctggaa ctgaaaccaa gaaaatggaa attagggcac 23520
cacactttga aatgtattaa acacttgaaa aactgttata tcttatagga tttccaaaaa 23580
gagttcttca gtgcctcaga agatttttat aaaaagcaat tatctacaat aaccctcccc 23640
agtattaagc tgaaatatac acatacctta gtaaataata ggagcatttg ggaagtggaa 23700
gaattgcctc ttaatagcta ctggacttga agattattaa atttgagcat tctaattcca 23760
tttttgaaag tttctgatat tgtttcttaa ttttgttacc atgtttaatc agtatctcac 23820
tagcctttca ttcatttctt tagcttctgt tactatcttt ctacttttaa gatactcata 23880
tcttcatttt ctgccacatc aactttcagt aatattcctg attcctcact atgttagaca 23940
gtgataatag tgtctcattc ttcctttcaa gtctttccca cccttctaca aaatgttata 24000
tataattact ttttaaattg tcaagtattg ataacatttg cattctgttc tataaccata 24060
tttaaatcct ctttcttttt aactatagat agattgtaat agttgaacct agtactattt 24120
acattaatat tatataaaaa tgtttcactt tacaaccaag tagagtgcta cagttggatt 24180
tctttctctg aatctgtgtc cagcatcatg aactacgcaa tgaatattct ttgcattcag 24240
atcatatggt ttatcttttc atatattcca catactgctc aaaattgtgc tcttttgctt 24300
catttttagc atgatgttat acattttttg ttttccccta aagtttccaa ttacttttct 24360
tttttctatt gtgaaaacca taaaaacggt attcagcgtg ccattagtgc tgctggactc 24420
ctcagttctt catctgttgc ttcaaacctg ttgtattgtt tttcctgaat actttttact 24480
ctggaattca gatttcatct tcaagtttgg gcatattact ttctgtaatt aaagtttatc 24540
tcaggactgc tttttcttaa tgatttgttt acgttatttg accactggtt cagttccacc 24600
atttctagca tgtggtctct tcctctttct tgacctccac ctttggttgg ctagagtaat 24660
taatcaatta agtgccttag aattggttca ggggaagtaa aactttggaa aactaattgt 24720
ctgaaaagac ttttattttt tctttacaca tgatagtttg ctgagtatag aattcctggt 24780
caaattgttt tccagcattt taattactgc attgtttttt acttgttatt gatgagaata 24840
gcattgccag tcagataatt tttcttttgc agattacttg tttttccatc tctgaaagct 24900
tttaagcttt tatctctatc ttttattgtc tagtatagtt ctttacattt attctgccca 24960
ctggtccctt ttaatctaaa catgtaagtc tctccagctc ccagatgttt ttcttttata 25020
tctttaattt cctttcttcc atttttctct tacctcagaa cttgtgcaat aaggaagtat 25080
tcagttgttg aacctctttg atttattgta tatctttttc acccttgttt cattatgtct 25140
gtctttttgc tctatgttct agcaattttt taaattttgc aaatataggt gaaatgttat 25200
atccttatga ttttattttt atattgtgtt tgttattcta ttaagattca tttcaatata 25260
aggtataaat tggaaaccca ctcttttttc ccaaatgtct agccgtttcc aggtggtctc 25320
ttccctattg atttgaaatg atacctttat catgtaacac attctgtgtc tattttttta 25380
atttctgggt tttttttcct tttgtctggc tctttatgag ccgtatctta ccattgtgat 25440
tattgtagtt tcataatttt tttttctaga gaagagaagg tttggttaaa cttttgagat 25500
gtttatttat tttcccacgt caacaatcat ggactatcat gttatgttta tgagtggctg 25560
agtcatatct cctgaggaaa acatagcacc attgagtgct acagcatcct atagagaact 25620
tcagtttttg gtcatactgt taagacctct tggtttcaca gccccacaag ccctctttga 25680
agtgacctat ccagtagggc tagacctttc tctccccctg ccttctcccc tcccctaatt 25740
tttctggtct cctgcaattt ttttttaaac attagaatca gcatgcttaa ttctacacac 25800
aaacacaaaa atcctattgg cattttattg ggattacatc atatgtgtag attatctaag 25860
gaagaattga cattttggga attggttgtc ttcctatccg agaatgtgga atgtttttcc 25920
atgtcttcaa tcttttgtgt tacttgggag cattttaaag ttttcttcgt ttattttaaa 25980
gcagttaaaa ttcatttttt ttcagttcac gtgactaatc aattctacca ggaccgtcta 26040
ttaaataatc tgtcctaatt aaggttctgg ggtttttccc tatacaaaat tgcagcaact 26100
attgtactta agtttgtttc tgaactcagt tctgttctct ggatctgcat gggccaatac 26160
tattctattt ttataactaa ggatttaata cctacttagg ctagcccctt ctcattactc 26220
ttctttcaaa cattcagtat attaaaagct gttataatac ttcttactct gttttagagg 26280
tggacataga cattacacac atacaaaaaa actgcaagcc aatctcactt aaagtattag 26340
ttatcttaaa taaaatatta gcagattcag tagtttgtta aaacacacac acataccata 26400
gccaaatggc atttattctg gaaatacaaa ggtcatttta atcttaggaa atctgtaaca 26460
gacattaatt ctctctcttt ccctgcctcc cttcctccct ccctcttcct ttctccagca 26520
cagacatgca catgcgcgtg cacacgcgcg cgcgcacaca cacacacaca cacacacgac 26580
cttagtaaaa tagggataga aagctattct ttgacgtact aagtaataga tataccaaac 26640
tagaagcttc agtcaggctt aataatgaaa gactcgcatt gtcattcata ttacgaataa 26700
ttcaagaaac aatcaatagc tatttttttg ccttgctttt gtaagggaaa aaagtaatat 26760
aaaggagaag acatattcgc aaattttaat ttcctgtatc agtttctcct gaccactcac 26820
tcacattctc cccaaagtga agccaatgtt ggtaacggag tgaattctag tgggggacat 26880
tggaggggat atagaaatac gtttgttcat atatgctttt taacacagat ttttaattgt 26940
attagtataa aagtgtgata aacatgcttt cattttaaat atcttctgaa cctataaatt 27000
atattcccct tttaaatttt tgtttaattt ttatcatcaa aataaatgta tcttccagta 27060
aggacagtgt gaggaggttg gatgatttcc ttcttcagaa aacaggcatc aaaatactgg 27120
agtaactgtg ttaatgtcag ccaaaataga ttgtaagaaa aggagtatta ttagagataa 27180
agaggaacat ttcaaaatta tgaagtgaca aatatggcag gaaaatataa aaattctaaa 27240
tgtatatgca cttaagagag gcacaaaatg catgaaacaa agattgatag aactgagaga 27300
tgaaataggc aattcaatat ttagaagagt tggagatttt aatactcttc tctcaacagt 27360
tgataggata agtaaacaga aaacaggata cagaagacag gaataaagca atcagccaac 27420
tcaatctaat tgacatctgc agaataccca acaacagtag aaaacacatt attctaaagt 27480
gcattggtaa cattagccag ggtgaatagt atactggccc acaaaaatga aatgttttaa 27540
taaatatgga agaattgaaa ttatatggta tgttttgcaa ctacaaagga attaaaaatc 27600
atggagagaa ataaggaaga aataagtaaa atccccaaat atgtgcaaat gaatactatt 27660
tctgagtaac ccatgggtga aaaaagaatt cactgggcaa aatagaaaat atttttaact 27720
gagtgaaaat gaacacaaaa tgtaagaaaa tatttggtat gtagctctca ggcagtgcta 27780
agaaagaaat gtttggcttt aaatgcttat gccagaaagg aagaaaggtt aaaaagtcaa 27840
ttatctaagc tactacctta agaagctaga aaagaaagag taaagtgtac caaagtaagt 27900
agaagaaagg gagtaataaa gatcagaaca gaaatcaagg aaatcaaaag ctggttcttt 27960
aaagagttca gtaaatcttt agctaaaatg aacaagaagg gatgtaaatt agaaatactg 28020
agaatgaaag aatgggtatt actacagata ctataaatac taaaaagata aaggaatatt 28080
atgaacaagt ttacaacaac caatttggca acttagatga aatgaacaaa ttctttgaaa 28140
gatactaatt accaaaactg actccaaaag aagtagaaaa tctaaataga cctatataga 28200
gtaaataaat tgaattagta gtttaaaact tccaataaag aaaatctggg ctttaatggc 28260
atagctagta attctgtcag acaccaaagg aagaaaaaaa tacaagtccc aaccacattt 28320
tcagaaaagc aggagggagg agagcatcac aattcatttt atgaggacag tattactaga 28380
taccaaagcc aacacaaagg catcccaaga aaagaaaact agcagccagt attcctcata 28440
aatgtagaca caaaaatcct tagcaaaata ttagcatgtt taattagcaa tattatattt 28500
aaaaggataa tactataatc atggtcaagt aggatttatc ccagcaatgc aaggctcact 28560
taacttagaa atatcaattc tgtgtaatat accatactaa taagatatat ttgaaaaaaa 28620
agtgatcatc tcaatagatg cagaaaagta tttgacaaaa ttcaatacaa attataataa 28680
aaactcttag caagctagga attgaaggca acttcctcaa cctgataaag aatgtctgtg 28740
aaaaaaaaaa tcatacttca tggtgaatga ttttatagtt ttccacttaa gatgaagaac 28800
aaggcaagga tgtttgctct tactgctttt attcagcatt atcctggagg tcctagctaa 28860
tgcagtaagg caagaaaaag aaatttaaag gatatttgga atggaaagga agaagtaaaa 28920
ccaaatagat ggcatttata cagaaagttc taaagaatct accaaaaaga aaaaaaaaaa 28980
atactagaac taacaagtga cttaggcaag gctgtagagt aaaagataac aaacaggaat 29040
taattatatt tctaaacact agcaatgaac catccaaaaa tgaaattaaa aaaccattta 29100
cagtagtatt gcatagctaa atacttagta ataagaatag atacacaaac ctgtacactg 29160
aacactacaa aatattgttg atggaagtta aagaagaact aagttaattg agaggtacac 29220
tatattcatg aattggtaca ctatgttcag tgcagtccca gtcaaaatct tgtcagattt 29280
tctcatagaa attgacaggc tggttttaaa atttatatgg aagtgcaaaa aacataacca 29340
cacataaaaa ctataaaatc tgaacactta caagtacctg atttgtactt gctataaagc 29400
tacaataatc aaaatagtac agtattagca taaggataga catatagatg gatgaaagag 29460
atttgaaaat ctagaaagag taattcttaa tatagtaata tttttcaatt aatttcttat 29520
tttggacaat tggtatatcc tatagatctt tttcccgtga tttaatgaaa tgtaacattt 29580
ataataattt tctttttatt gaacattttt gctttgtata ttatatgtta ccttatttgt 29640
taataaaaac acataaataa acttggttag gtattattta tgtggtaact gattttcaac 29700
aaaggtgcca aggtaattca atgggaaaag aatagtcttt tcaaaaaaaa gaaaggccgg 29760
gcgcggtagc tcacgcctgt aatcccagca ctttgggagg ctgaggcggg ttgatcacga 29820
ggtcaggaga tcgagaccat cctggctaac acacagtgaa accccgtctc tgctaaaaat 29880
acaaaaaaaa aaaaaaaaaa aaaaaactta gccaggtgtg gtggcgggcg cctgtagtcc 29940
cagctactcg ggaggctgag gcaggggaat ggcaggaatc cgggaggcgg agcttgcagt 30000
gagcctatat cgtgccactg cactccagcc tgggtgacag agggagactc catctcaaaa 30060
aaaaaagtgc tagaataaca aaaaatttat taaaaatgga ttgatggttc atagacctaa 30120
acttcagttc ttaccccagt aattacctac gtggtgtatt gacaacaaag gaagaaaact 30180
tgtagaggtg ggttttggca gtgttttttt gtttttgttt agaggtggag tttcactctt 30240
gttgcccagg ctagagtgca atggcacaat ctcggcacac tgcaacctcc gcctccctgg 30300
ttcaagtgat tcttctgcct cagcctccca agtagctggg attacaggcc cctgccacca 30360
cacctggcta attttttgta tttttagtag agacagggtt tcgctatatt ggccaggctg 30420
gtctcaaact cctgacctca ggtgatccac ccgcctcggc ctcccgaagt gctgggatta 30480
caggcgtgac ccattgcgcc cggcccggaa gtgttttaaa acttggttgt agtggtggtt 30540
tttacaacta tacattcacc aagactcatc aaactgaatt ttaatttata cctcaggtaa 30600
agctaaaata aagtaataca tgcatattat tttcaaatta caactgaaag gttaataaaa 30660
acatcaggcc gagcatggtg gctcatgcct gtaatcccag cactttggga ggctgaggtg 30720
ggcgggtcat gaggtcagga gttcgagacc agcctggcca acacagcgaa accctgtctc 30780
tactaaaaat acaaaaaaat tagctgggca tggtggcaag cacctgtaat cccagctctc 30840
gggaggctaa ggcaggagaa tagcttgaac ctgggaggcg gaggttgcag tgagccgaga 30900
ttgtgccact gcactctcta gcctgagcag cagagctaga ctccatctca gaaacaaaca 30960
aaacatcagt tcattactgt atctcacttc ccccccattc cctctcacaa ctttgtcttg 31020
tctcatgtca tgcttcagga aaccactttc aactatttaa gctactactt ctggtatttg 31080
ccaccttata ataatggggt atattgctct gtcttggtcc accaatattt gacattattc 31140
attagttttc tcttataatt ttaatgctca tatcttcctt tgccttatct catcatccta 31200
tatttaatca ttactggtta aatccacatt tagttatttc attattcaat gaccatatag 31260
taataaagca aatgctacat ggggttatat tttttctgtt acaactttct tgttgttttt 31320
taattaattg cttcatctca gaaatctgct tagttaccat tgtgtctgaa tttgtctttc 31380
catgggcttc aatccatctt tgcaataact ctcacatgtg ataattagtt tggttatttt 31440
cctataatat ccttcataga gccttcagta tttctgattt aatcttgatt gcttgctagg 31500
tctgtttcac agctgttatc tcaagactct tttttgtctt catcctggaa attccctaca 31560
cctgcttcct gtgttgaagc attgattcct cctatgcccc ataccttcat ggttgactac 31620
ctcattctat aggagcttat cctctcgtgg catcttgaag agagataact gggaggtaat 31680
ttttttgaga ttttacatac ctgaatatgt gttattctac tcctacaatt atgtgatatt 31740
ttaagtgagt gtagaatgct agattgaaaa tcatttttac ccagatattg ctctggtatc 31800
ttccagcttt caattttgct agagttctaa gtgccactct gtttcctgat tttttattta 31860
ttcttttttc tctctgtctg gaagtgatta atctcttctc ttcattttat ggtatggtac 31920
cttggtgtgc atcgtttatc tgttgtgctg tgtactccgt aagtccctgc tgcttgcaga 31980
cttacattct tctcggaagt atccttgcct tttttggtag ttccctctcc tttgttttca 32040
ttattctctc tggaactcct actagccaga tactacactt cctagattgt ttttctaaat 32100
ttttaccatt ccctcctctt actcatccct ttctttttat tctgccttct ggaaaattgc 32160
cttaacttta acttcaaaca tttgttgatt tttttttttt ttcagttctt attctctggt 32220
cttattggtt cctctgcata aggatgcagt cttttatctt tacagtttct ttgacatttt 32280
cctctgtccc atcattctct gtttctcacc acttctgttt cattttggtc tcaatcttta 32340
atattggaga cattcctcaa atgcatgaag atcctcagtg gtcatttata tttaaaagat 32400
gtgaaaagct gaccgaaagc tctgggtgtg aagtcagagc tcttgtctat tggtaaacta 32460
tgctgtagga aatcttcata tcacaatttt tctttaggtt agttttgttt tctctagttt 32520
tgaatccttt ccagaggaaa tctatagtct tctctgtggg ggctgcttat gttttagaga 32580
aatactgaag aaagggactt tgggtctctt tagagttgca cataatcttc tggttttagt 32640
catatctact tctgtatcta ttgaagtcca aagcatcttg agtttagttt ttccagaaat 32700
tatgccttct gatttctgca tgattgggaa gtcactgagt acaccaactg gagttggaga 32760
cctggaattc cagtagttcc aggaacctcc tagtcctgaa cttaatgggg tttcatgaga 32820
attgactggc ttctttaggc acttaaattt aacattcctc acctctggtg aggtttttgt 32880
ttgttgtttg ttttttctcc ctgtctttgt atattatggt ttagggttac agttttccag 32940
cttcatcaaa aaaagagttt ttctcattct ccttgtttag aaatgattgg tgacacaaag 33000
gtctgtactc tgatatttta agatccgaag tgtattctac ccctttttta taaactattt 33060
tgcagctgtt ccttcacgac tttgctacat cttggagatc ttttcatgtc agtacctaca 33120
agtctatatc attgatatta tcagctatat agtactccat aaaatgcttt attataattt 33180
atgtaatcat cttcctattg atgaagattt tggtggtttc tagtttttgc tttcatgaat 33240
attgttgcaa tgaatattgt ttggcttact tttgggtgaa tttttacaaa gacatccata 33300
taataagttc ccagtagtgg ggttgcctaa tctaagaata agtgtattta aaatttgaat 33360
catattgtca gactgtctcc cagaaagttt acattcctac caacaatctg agagagctgt 33420
ctttgcagtt actaggtttc atcaaacttg tttttttcag tatggtaggt ttaaaaatgg 33480
ggatacattt ttgtttttat ttgcattttt aaatattttc ttaggttagt tggctactta 33540
aatttctttt tctgaaaact ttgtatttat agccttttaa aattcttatt gacttgcctg 33600
aactatttgt aaattacaga aattagccct ttgtcgtatg tgttgcaggt gcttttccag 33660
tttgccagtg gtcattcatt ttggtttatg gtacttttga tagaccagaa tctttgactt 33720
ttatttagtg agatttatcc atctttttct gtgtggcatc ttggtattat agcattaata 33780
ttctcttttc tttttttttt ttttttttga gatggagtct cactctgtcg cccaggctgg 33840
cgtgcagtgg cctggtctcc actcactgca acctccgcct cctcgtttca agtgattctc 33900
ctgcctcagc ctcctgagta gctgggatta caggcatctg ccaccacacc cagctaattt 33960
ttgaattttt agtagagatg gggtttcatc atgttggtca ggctggtctc aaactcctga 34020
tctcaggtga tccgcccgcc ttggcctccc aaagtgctgg aattacaggc atgagccacc 34080
acgcccaggc tatagttttt ctttatctga acaataacta attataaagt atagtggaag 34140
agaaaaaccc attcagaaaa ttaacaaaaa gatcacttat ctagaaataa acttaaacca 34200
tagcagagct tacatgaaga aatcttttaa aactgagcaa ggatttgttg gacaggacac 34260
agcactaatc tcaaaagaaa atttgatgaa taggtcttat tcatagtttt tgctcatcaa 34320
aagacagcat taagaaaatg aatagacaag ccacagaatg agttaaaaaa acagaaattc 34380
ccagcattta caagggatta aagatgtgta tcagaatata taaagaacct ctgaaggcca 34440
ggtgtggtgg tttacacctt taatcccagt gctctgggag gccaaggtgg gaggatcatt 34500
taaagctagg agttcaagac cagcctggta acatagtgaa acaagattct gtctttacaa 34560
aaaaaaaaaa aaaaaagtgt ttgggttttt ttttgtgttt tttttttttt gaagttagct 34620
aggcatggag gcatgtgcct atagtcccag ctattcagga gcttgaggct gtagtaagct 34680
atgatcatgc cactgcactc cagcctgggt gaccaagtgc gaccttgtct ctaaagatca 34740
aaaaaaaaaa aaaaaaaact cagaaattaa catttaaaaa attatgaact acttaatata 34800
aaaatgggca aaagactcga gcagacattt cacagaagat atacaaatgg ccaataagca 34860
catgaaaaga tttccaccat cattattagt catcagtaaa tgcaaattaa aaccatgata 34920
agataccact acaaattcaa accatcatga gatacccact agaatagctg aaataaaagt 34980
gactgatact actgaatagt tatgatatag accaactgga attctaactt attgctggtg 35040
ggaatataag aactatttct tataaagtta aacataacat ttacctaatg tgtcaggagg 35100
ttcccagaat catccctagg ttccatggtt cgctaggaca actcacagga ctcagcatga 35160
tgtcgtactc atggctctat cacttactac aatgaaaaga cacaaagcac agtcagcaaa 35220
gggaaaaggt gaatggggca aaatccaggg gagaccaggt acaagcttcc aacaatcctc 35280
ttccgtagag tctcacaaga cacacttaat tcccccagca aagagctgtg acaatacttg 35340
tgaaatctaa ccagccaggg aagttcgcta cagattcagt gcccagggct tttaccgggg 35400
tctgatcata ccctctgctc agcgcacacc caaattccag actcccaaag gaaagcaggt 35460
attaagcata aaccatattg ttatcataaa tgctttagac acatggagcc agtcttatca 35520
gatgggaatc agggtaggaa tcctcctaaa atccaagatc caagttccca gacaccaagc 35580
cagccttgca aacaggcttt tttaaggata agcataagaa tattaactct tttctgcaag 35640
tttacaacct agcattttgc taagtataac aaaaattgat gtaggaattt tgatagccga 35700
tgctggaaac agcccacata ttcaacaact ggaaattgta taaacaagct gtagtatatt 35760
ttggaatact acttaaaaag aactaaccac taatacatta aaacattgat gaatcccaac 35820
ctgttgcact cttctcattc tgtacctgac agtatgttaa ccaaaagaag ccaaatacaa 35880
gagtatacac tgtgattcaa tttatgtaaa gttaagactc agcaaaacta atctataatt 35940
acagaaacca aaatgtgatt gcctgggggc agagagagaa attaattgga aaagagcatg 36000
acagaatgtt ctaggataat agaaatgtat attatatatc ttgttttgtg cagtggttac 36060
gtgggtgtaa gaagttgtca aaagtcatca aacttaatgc ttaagatgtg cagagttcgt 36120
tgtatgttaa ctatagttca atttgaaaaa ttaactactg agaaacattg aaatccaatg 36180
acattcctat ccaaatacat atttggatag gaaaaacatc ttgtaaagat gtcagttctc 36240
cctgttctca aaataacaag aagttttgcc ttgatttttg tttttgaatt tagcaaaata 36300
ttcaaaagtt catctggaat tatcagccaa gtttaataag actgtgaagg gactttacag 36360
aagctacttg ggctgaattt aaaggatgag tatgattaaa atggcaataa atgtgaatat 36420
gaggtaaaag attatggagc atatttacaa aggcaaaaaa ctgtaaaggg aaaagattga 36480
tctagtaaga ttagagcttg gagtgtggga aaaataagag aagagcacag ttgtaatgtt 36540
tgaggcttga gtcaaggctg tattgcatag ttactagaga tccacaatat tgtcttaatt 36600
gagtaatggt gtaattagat atatgttttt agatagccaa ttctagtgac actgtagata 36660
atgaagtggg tggggagaaa ttggatactt tgtgctttca gggcctcttg tcttagttca 36720
tactgtctac ttaacctgtt gcactcttct cattctgtac ctgtcagaaa tcaggcccac 36780
tttctcctaa aattaccacg ttctgccttg tagattgtta gataataagg tcttttcaac 36840
ctcatttata tacttcattt atatacttgt atgagtgttt ttctcctcct ttcctttcca 36900
tcacccatcc ctttgcttca gctgctagtg tcttaataga aggtaattgc ttaatgaatg 36960
cttgttgaat tagagacaga tcagtcctgc atatgagaac tcttttaggg tctaatagtg 37020
atagagaaga ttgaaaaaaa aaggtgatga atttgagggt aatttaaggg gtggaagtga 37080
tgtcatgcaa gagaggagtt gaaagcacca aatgttttaa ccttggagat tgagaaagtg 37140
gtgatgtcat gaagaatgta ttccacattt gaataatgag cagagtaaga ggtaccaaca 37200
aatgaaacaa ttaaaggagg ccataaaaac aacagagatc atttcaacat tctattgagg 37260
aaatttgggg ggacacactt taattaaata ataacatcag tatttcttta cctttgtaac 37320
ttttaattaa tgaagatgtt ttaagatgaa atataaaatg tgaacctgag aactgtttaa 37380
catttaacat tatggatata catatccatg tttagaatgt tctctgtgta ttaatgcatg 37440
attttgtcat aaatacccca ctaggaagag aaaggtcgga gagagtgtgt gtgtctctat 37500
gtgtgtgtat ttgtgtgttt tgtcctggca aaaagacaaa ctgagagaac agaagaacaa 37560
aagagcagta ctgaaaatag ctagattaaa ggttgttttt ctgtcaccac acaccagata 37620
tggagagtag taaaagcaga cagatggaca gttctgttag ttttggagtg tgtgaataga 37680
gaaaagaaac attctgttcc ttttattcag aaaaggaatt tctagactaa attactggta 37740
tcagcaataa gtttcatatt ctgaccaaag aaacattatt ttttttttac cctagggata 37800
atgactcatg ctgttctcag aattttgctt ttgtggaaac taaagtgcag tcataaatac 37860
ggcactgtta tttagatctt agtgctaatg atactattgt gagtagacta gtgatgggta 37920
agaacactag tattataaac ccagttgtaa caaagaaacc aagcacatct taattagctg 37980
attctagatg ggaaagtaga ttttttaaac aaattaacta attgttttaa ttctgtgaat 38040
tatgcaatag aaataggacc cataatttta tttttttaat acttcattat tttgaggggt 38100
ttatgtcaga agttaaattt ctaacttcca atattgacag tggagataat taaacatatt 38160
ttctctgcct tttttcctta tgttcctcaa aattagtata agtctactaa atcatagtca 38220
catacaccat aaagcaccta tcaaaagagt atcagctagg tgaagttcaa agattatatt 38280
ctagttttat tttaaccttt aaagtcttgt aatttaagaa atagaggttt gaatgtcttc 38340
tttatatacc atagtactag atgctctcac tctgaatttt taccatgtca ggatactcca 38400
tcacatattt atctctgtaa ttataattat tgggcacata cacaaaagag ttgtccttta 38460
cggtatctct gtccaaccta aaaactttcc catttctctt cactttaatc tcttcagtcg 38520
ttccctttcc tgaattacct ctttactccc tagtgacggc ttaaagtttt agatcttaaa 38580
gttccctttt tcaaactttc ttacgtcttc ctctgtgcct ttattttaat gtcagcagaa 38640
gttagctcat gaatcataac atgtgaagca gttgtttgga ataattgaca gcttttaatg 38700
acttatgtta aatagccagt ttaaaagttt ttgtcagttg ataagcttta taaagaagca 38760
ttttaatgta ttaaatcatt gtaagtaatt tattgtttaa ctgcatgcct tgggtggtta 38820
actaatgtca tacagagcat cagtgaataa gagtggcagt attggctggg tgctatgact 38880
catgcctcta atcccagcac tttgaaagtc agaggcagaa agatcaccag agcccaggag 38940
ttcaagatca gcctgggcaa catggcgaga ccccatctct gcattaaaaa aaatttagct 39000
gggcatggta gcacacacag gtagtcctag ttcctagcta ctcgtgaagc tgaggcagga 39060
gaattgcttg agcctggggt tggggctgta gtgagccgtg ttcgtagcac tgtactccag 39120
cctggataac tgagagagac cctgtctcaa aaaaaaaggg taatattcta ctcactgatc 39180
atgtatgttg ctgcttttac acagttatac ccatttcagt ttgtcattct cattgcttgc 39240
tttttaaggt atagtaatta taatttccaa gatacttggt acattgaact gtacataagt 39300
ataaataaat agtaaatgct tgaaagggaa aataaagacc acttactaat atttctctcc 39360
caccattgaa gtattttggc tgtattgtat tatcgaaaag atggattttt tagaaatctg 39420
tgcttacatg acttcacatt gttgttgctt tcattcatag aacttgtctt cacatcttag 39480
ctaggtgaca cttgtgctga aattaagcta ccctctctct gattgcactt ctgggagatc 39540
tgagtttctt tgcttgccaa agttattact tcaagctttc ctgttgtgaa atagcccttt 39600
tgccagagat caaatactga aggatgataa atcactatta gtcaataatt gcttgcaatg 39660
gacattttca ttattactaa cataatacta ggatattttg ttattgccag aaaatggggc 39720
agatggcaac caattacatc aggatataaa gttattgttt ggtctttatc atggaaaaag 39780
cattgttatt taaatcaaat ttttactgta tatcatgtct ttcatccaat gtcgtaacat 39840
cccagataga cttggggtgt attcacttaa aaaaatacaa tatcttacgt tcattagagt 39900
atagttggaa gaaaatgtat tatttttgca agaagctgtt tatggattta tctgattaat 39960
ttatgtagag ccaggaaaaa gttgttttga ccaataaatt tggcatttga aatgagcagg 40020
ttaagaatag acattaagtg atcaccttaa gtgcaataaa atttcagtgc actatacatt 40080
ctgtgcttta tatctatttg taagaatacc aataatatat caatatggta taagaggaaa 40140
gaataagaga ttactataat agctcctaag aaaggaaatc agtccaagga cataggctga 40200
ggttgtgatg tggacaaaaa gataatagca aggatagata aataactaga caaaaatgtc 40260
agggacctaa gtatttatat ggcaaacaag gatactcagt acatctagag ccagactttt 40320
tccagtgtct aatccttgtt gtatattaaa tactttggga actaaaatat gttttatgac 40380
actgtgttaa ctgatgcata attatgtaat ggaagccatt agggcctgtg tcttggcagg 40440
aattaaacta aaagcaaggt ccttctagta tttttggtag aagattattg gctagtgcct 40500
attttcacag cacatactac taaaattagg aggacgacag aagacgagca ttgcccctcc 40560
ctgtgcaaaa ttgatagaca cattcaagaa gtattccata tttttaagct aatcttttta 40620
tttgattcac ttaccagcag gctgttttcc tgctgcaaag caaattggtg gagtccattt 40680
acaccttctc cttagcctat aagtattggc agaatcacca ccacgatcac agcagcacag 40740
tccagacagt gtcatttgat tttgaaaata ttgtccttgc aacagccagc taggacaatg 40800
acatactaat atctgctttg cttattattt gtgcctggga gtatgtaatc atagtcaaca 40860
gacaccatag ctacagtttt atgacacttg gtctcaggaa atagagaact ctacagaaga 40920
cagtagacca tgatgaagct ttatcattag tccctggttc tctcccctcc agatcacttt 40980
ggccttctga cagacagtac agataaatct gttaagtttg gaatgttgaa ttggtcaaaa 41040
atgaaaataa tagtccaaag caaaaagacc ttctgtgaaa catatgtgga tgcaattagg 41100
tgaatatatt gtatctgctg gtgtccccaa agttgatagc tttatttatt ggaccagcct 41160
agactgaaaa tcttctgttt aggcattttg gtggggattt tttcccctct gtggataccg 41220
actgttatat ttaaggaaga tagaacaatt ggttctacca agaaacctgt agctaaccca 41280
agtttcactt tatgatggca gcactttaaa agtttggtat gaaagactca tctcttcttc 41340
attctcaaga caatagggct aatcagtgag atgcaggcaa gttttaattt atctaaatac 41400
taaagagtat cactagaagg gatagtactt gaatacaagt ccctatggtg actaaattat 41460
gtcctcaccc catgatataa ggaaataagc tagccgttga tttttgatga agaaagactg 41520
tgggaacagt gtgtagcaac tgttttccaa gaagttatcc actctcaccc atagtagtgg 41580
aaagacttga aagaaagttg ttgaggtgtt cagagccaca gaaaggccta ttaagtcatt 41640
gagctatact agaaagaaac ataaaaacaa aagagcagaa gccatttgat aaacttcagg 41700
ggggagaagt tctaatccct gatgacttac agaaacatct tgccttcagc ttcttacaga 41760
tctttaaaag aatcaggtca agtgatttga aagacatatt gctaatatta cctttttcta 41820
gattctgtag aaataaacca tttttcctct gctctcacac tacaataatc aacacagaag 41880
acttctgtaa ctgctggtcg ccaagaagta tatggggatt tctccccacc aacaatcagt 41940
cagttgattc tgccgcagat tcttcaatag acagcagttg agtatcctgt aattcaattc 42000
agttctgaca ctatctgcct agagatagca tcagatccca tagattgagg gctcagtcac 42060
aagactgcca tccatttcca atggcagtca taagcttcag gttgttttac ttgtgcttct 42120
gactgactgg ctataaatca gcgttcccat gaccccctcc ttgggtttga ttaatttgat 42180
agagcagctc atagaactca gggaaataca tttctcggtt tattataaag aatactacaa 42240
aggatataga tgaagaagat gcatagggca gggcttgtgg gaaggggtgt ggagcttctg 42300
tgccctctgt ggacacacca ccttccagga acctccactt gttcagctat ccagaaggtc 42360
ctcgaactca gtcctttttg gatttttatg gaaacttcat taagtagcat gattgattaa 42420
ataattggcc attggtgatc agcttaacct tcagcccctc tctcctctga ggaggtgggt 42480
agggggtgga ggtaggggta ggactaaaag ccccagttct ttaatcttgc cttggttttt 42540
ctggtgacca gccctcatcc tgaagcaacc taggggctgc cagccaccag tcaactcatt 42600
agcatacaga aagaccctta ccactttgga gattccaagg aatttaggag ctgtgtgcca 42660
ggagagagga cagagactaa atatgtattt cacaatatca catagatgtt cttaatttaa 42720
ttaagatgtt aatctagata ttcttaaact cttaatgaac tcaacaagct gagccctgga 42780
taatgtaccc ttttgtttct ttctttagct cacaagaagc caggaaacaa ctattttata 42840
agtcagccaa gtccagaatg gtgttagctt cattatggca agaaagagtg aagttacttt 42900
tcgtgaagcc ctgggctttt tgaagaaaaa gagaggagag gtggttttaa cattgacttt 42960
aagttgaaaa gtagagccct tttatacttt tttctttaat aaatccatca atcaagaatg 43020
gaacaatgtg tggttagcat catctttgaa gttccaagtc acaaagggat tttcttcctg 43080
aagtatgtgg gatgtgagtc atttgtaaat gggaattacg aaggacaatg agccctattt 43140
tttttggtta tcatcaatat aggtttggtt ataaacttgt tgtaaagagt taaaccatca 43200
ggaccttttc tcttagagtt ccacaggagc tgaaatgttt gcttagtagg aaatcgcagt 43260
aacatttcaa gaacccttcc gtattttgca tttcctttat attagaccat gattccttgc 43320
taagttggtc tcttcattga tctcattggt taaattttca ttgaggcaac caggtgcata 43380
gacttctatt ttcactgtct tcagtatata cagttggtcc tgaaatggat atacagctgg 43440
caaacttaaa taccttagga ttgtttctct ctttatgcaa aagatgctat tttttagtca 43500
ttttataagg gaagtgtttt ttttttccta atttaaaaaa ttaccctcta tatgataacc 43560
aaatttcctt taagtgttgc ttcagtgaac caaatagtgt tttactaagt gtaggagttc 43620
tagctagata atatctacca tctctttaca acaagcctga aacagtaagt tctgtttccc 43680
tttctggaca catgcattta gataacattg atccagtaga taagagaaag ggaggccggg 43740
tgcggtggct cacacctgta atcccagcac tttgggaggc cgaggtgggc ggatcacgag 43800
gtcaggagat cgagaccatc ctggctaaca cggtgaaacc ccgtctctac taaaaataca 43860
aaaaaattag ctgggcgtgg tggcgggcgc ctgtagtccc agctactcag gaggctgagg 43920
caggagaatt gcttgaaccc gggaggtgga ggttgcagtg agccgagatc gcgccactgc 43980
actccagcct gggcaacaga gcaagactcc gcctcaaaaa aaaaaaaaaa aaaaagagag 44040
aaacggatcc tttattgaat ttctgtgttc caagcactat gctgagaact ttacatatac 44100
catctcattt aattcttttg tttgtttttc tttgggatgg agtcttgctc tgtcgcccag 44160
ggtggagtgc agtggcacca tctcggctca ctgcaacctc cacctcccgg gttcaagcta 44220
ttctcctgcc tcagtcgccc gagtagctgg gactacaggc gcccgccacc atgcctggct 44280
aattttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcgatc 44340
tcctgacctt gtgatccgcc cgcctcggcc tcccaaaatg ctgggattat aggcatgagc 44400
caccatgccc gaccctcatt taattcttat aacattactg tgagatagta actattttta 44460
ttcacctttt gcaaataagg aaactgcctt caaatgagcc tacaaagaag acttaagaat 44520
tggagagttc tccctagggt cagtggaatt caggatgatg gtgcactgat ctcaactaaa 44580
acgaaactac tggttggacc atttcttctc aggactagat tgtgttaata cacattcttc 44640
tctttgctac tatatgttaa ataatctgga gatttccata atgtttccag gttccttggt 44700
tactcatttg ctacaggtgt tgctaaagat gtgtaaaagc tcaagtcact agttaggctc 44760
tctttgtggt ttgattagct tttgtccttt tctttggcca ggagacactc taattctgtc 44820
cacctgtctt accagtgcat gccattggtc acaaggtggg ttggttaata taaaggaata 44880
aatgaattgg agaccaagta ttgtactact ggaaaaacaa aggcaaatgt tagtatattt 44940
ttttccattt ggaatagtag tcattctttt agttctgtat tttgaaatca ttatttacca 45000
atacagtctt cttgatgtga aaatgcaaac agagttttca gtgttacctg atttagggtc 45060
actggaactg agagtgatgg tttacttctg actgcctgct gctgctttta tgtgaaactg 45120
tgataatctg ccttgactcc cttcctccta ggaaagaaag aaataaaata attaaataag 45180
aaaaatattt agtagaaaac tctttatcac tgtggaatca tttgtatcct attaaatggt 45240
atattatgaa atatatatcg ttttccacat taagtacatt tgccttttct cataatccta 45300
tctcaccttc acctttatta atgtttagtc acattttgag cttatatttt aagaaacttt 45360
aatttgtcct tttgcatgct gaaatttgaa tttttaaaat tcaagtatgc tgggcacagt 45420
ggctcacacc tgtaatccca ggactttggg agaatgaggt gggcagatca cttgaggtca 45480
ggagttcaag accagcctgg ccaacatggc aaaaccccat ctctactaaa aatacaaaaa 45540
agttagctgg gcatggtagc acatgcttgt agtcccagct actcgggagg ctgaggcagg 45600
agaattgctc gaacctcgta aacagaggtt gcagtgagcc gaaatcatgc cactgcactc 45660
cagcctgcgt gacacagcaa gactccatct caaaaaaaaa gtaaaaataa aaaaataaaa 45720
ttcaaattga aaaagttcat tttcacgatt aaattcatat ttacagtgct gccaaactta 45780
aataccttag gattgtttct ctcttcatgt aaaagataca taaagtgact acacatttca 45840
gtatctggta tggtttctct ttataaaata caaaatttaa agttcatgct ttatctaata 45900
atctaagatc caagtattaa tctatacttc attaatggtt ctttaccaca tttgattctg 45960
ctattcaaac tggattcttt taacccaacc ttggtcacat ttactgataa tcagaagtcc 46020
acattgctat aaatactact cacctaagcc ttgattattt gtcattaaaa aaaaaatgtg 46080
ttagcacaga tcctctctaa acccattcat gggcctcata ttaggaaacc cttgtcttat 46140
ataatgcatt aaatctctga aatatatttt tataacatgt ttcttagcac tgtaaatatg 46200
aatttgataa tgaaaatgaa ttgcagttcc tcactaaagg aatttaaatt ttttgcatac 46260
tagtgatgag gacttgattt tccaccctga agttgtaaag gtctttcagt ctctctaaaa 46320
gtgtgagtta aatctgtttt ctcacggcca gcttttaaag gtcagtgaag gacggcactt 46380
tgaaagaaat ggataatatg catccttcca gagctagtat atattacagc tgtccctttg 46440
gactcactcc agaaacagct cagtgactct tagaggaaga gaattttaga ggccctaact 46500
ggggcccaga aaattgtact gaaggatact tgcttcctgt gcatctccac tatagtaaaa 46560
tttgtttaaa attacgcttc ttagccctca aatccaaatg gtctcttgag tgcttttgat 46620
ttttctttaa ccatccgttt cctactattt ctactgctac ctcgctttgt tcaggccctt 46680
gttacatttt cactagagta atttcaacaa tttagttttt ctacctgctc ttctatgctc 46740
taggattata gtgcataaaa aaaagtgcac tatatatata gtgcaccccc cccaccaccc 46800
ccagcataaa agaccctatc ctgaaaaagt tcatagccta ataggaggtc aaacatgact 46860
acagataatt ttaatgagta tgttgaggta cagttataga aatacatata aaaggctgtg 46920
gtaacattta aaaagggagt aactgactct agaaatattt aaagtaactt tcaactgcag 46980
taataagacc attgaattat taacccagat ttgaatcatg ttgtttctgt agcaaatgta 47040
gagggaagtt ttgttctcct gttccaaatc agactaaaga ttcatttggt aatttaaaaa 47100
tcagaaaagc tttttttttc tctctctctc tcgttaatgg gttgtagggg ggtgaaagaa 47160
ccgtctctgt ctcctctgga ggctcagtat ttgagtccaa gaaataaact tgacagtaga 47220
cagattaaca ggagaaaagg catgtaaatg tatcgtatgc atatgcatag gggtcctaca 47280
aagtatgaga ctcagataag ggccagacgg ctgaagctta aatagtactt ttagctacag 47340
aaacaaatat gggcttaagg ctcctggagg gtgaggggaa gaactgtact gtgaacgaaa 47400
attgtcttgc tctgcggata aagtctctca gatagtagcc ctcagaagaa taggtgaaaa 47460
gtctgtatgg gcctggtgtc ttgggtgtgc ggacctctag tctcctctcc tgtgatagga 47520
gttaatgtaa attccagaga tggggttcac aattccattc cttctggagg aacttccgtc 47580
ttgataaggg aaacttcaga gaaagccctt tcttcacttg aggagagaag atgaagagac 47640
agaggtacag gggaatgtca gaccttggtt ctgatgctgc ttttttagtt caaagaactc 47700
atcatgtcaa agtgtcatac tttggggtat agtttcctga cccctaacat gagcaaataa 47760
agagatgtaa ctgagttagc cacaaaacta tttttttctg ttggctctat ccaaaaatga 47820
gagtggaaaa tgttctgtga acatatatct aaaagtatgg gtaaaacttg ttttacaaac 47880
tgttggtcat tcagcaaaca tttaaacagc ttctatactt gtggaacata aataactaga 47940
aaatacaagc tgcttatttt agcaaattgt ggctgtttgc attgctcagg ctgccagttg 48000
tgccaattgt gctgaggtat gcttcaaaat aactttcttt cttattttta atgacttttt 48060
aatgcaggta caatatcgat gttttaaaaa cataagtatt tggtgttttg ttttgttttg 48120
ttttgttttt tgagatggag tttcgctctt gttgcccagg ctagagtgca atggcgcagt 48180
ctcggctcac tgcaacctct gcctcccagg ttcaaacaat tctcttgcct cagcctccca 48240
agtagctggg attacaggct cccgccacca gggcccagct aatttttgta tttttagtag 48300
agacggggtt tcaccatgtt agccaggctg gtctcaaact cttgacctca ggtgatctgc 48360
cctcctcagc ctcccaaagt gctaggatta caggcatgag ccaccacgcc tggcctaaaa 48420
acataagtat tttaaacata atacactttt gaaattgaaa cctgaactga aatatataaa 48480
atatactttc tgcatatttt aaagtagtta agccagaaaa catcttaggc tgtatttata 48540
gagactggta atccatagtc aagtaatagt tttctgtact ctgccttgga aatactgatt 48600
ccagaatatt gtagtagatt ttcattgcca cattttgaga tgaatattag caaaagggca 48660
tatccaatga tggcaaaaat gagatggtaa actatcttgc ctgaattatg gttgaaggaa 48720
ttggtggaaa aagacccagg ggaaattcta atagctttca agtatgtgat gagatagaga 48780
aagtggaact gagggaatga acaagataat ttaggagtaa ctatgtttag ggataacttc 48840
agaattactc cacaaaaagt tccctgtcag gcagtaagct cccagcaatg aaagtaccca 48900
cttaaatcac ttctgagata ctttcctatt tcaagatttt aacttaaggg cttaaagaac 48960
ttaggttgac actgtatagg actgtagttt gcagaggcag ggtttgggat aacttcttag 49020
ccactgggca cttatgcggt tgataccagg taattctaat acattacagg gatcagcaaa 49080
ctttttttct gcaagatgcc agatagtaat attttaggct ttgcaggcca tatggtctct 49140
atagcatctg ctcaactctg ttgttgcagt gcaaaagtat tgttgacatt atgtaaacac 49200
agtttgttac ctgtgttcca ataaaacttt atttacaaaa gcaagtggtg agttggattt 49260
ggcctgtggg tcatgctttg acgacccttg ccttaactaa tgaaatctag aaatagagtt 49320
ctaatgtaaa tatagaaagg ctttcaatct agggattaaa aatcgaactg tcaagatgtc 49380
attgtcttct tggtctgaaa gagtacacat caagtgttca aaatagtgaa ttgcccaatg 49440
aattaagaaa ccttccagta taaaagtcaa atgacaatgg agaatctgat actgtttttt 49500
actctttatt tctgctactt aacgttgttc ttaaaggcgt cgttacttct gctgggtagt 49560
actgtctact cagttggact gctgatgcag acccagtcca taccaacaag ttaacacagg 49620
ttcaggcctt ctgagaacca aaagattttt aagtacttcc ttcctaaata cagtaacttt 49680
taacagtaat tttaacacca gaagcaagaa gtaaacaaaa atctctgatg atcgaggcat 49740
ctgttgtcat atattttgtg ctcctaaggt catacagcag agcctcttgt attatctttt 49800
ggtctgttgg cctttagttt atagtttgta aaatggtggt cacatgtcaa tgctgactag 49860
aagaaggaga tgctactgta atcaggcagg ttggccttcg ctgagaagtg accattgatt 49920
gctagaaaac aaagaaatgg gaggcattca gcaacctggg gttgttggtt ttaggaccag 49980
aaatgtaccc ccaagtctcc accaaatttc tcaataatcc tgaagagttt tgctgtttgt 50040
gttttaatat aacacagtaa ttggtgcttg taatgaggac tataattcat caaaaaggta 50100
aattgtgaat tgtgcacacg cacacacact cttctaagca aatgggactg ctctattttg 50160
aacagtcttc aaattgaaat aacttatttc gatatgtaga aaattaggat aagcaaaacc 50220
aatttattta ctcttaagag ttccagatag tagtgatttg tcagtatgca tatgaatctt 50280
tagtcctggc attctgaact caaaacctca atagagtggt ttcttgaccc ttaaagtgtt 50340
ttatttttag taaatacatt tttaattctg tgacctcaaa cctccaagct acattatgat 50400
ttcataattt tatagtgatt tatcccccca ttgctttaaa tttaataatc ccatcctctt 50460
tattggtatt taattttttc tgtagtctaa aggccctttt atttaaaatg ttatatattc 50520
tgatttctta attttaggga tttttctcta gacaattgag aatatgtaat ttttacactt 50580
taatgttcat ttgattataa cctacacttg aaaagcaatt tttaaagaaa tctgagagaa 50640
tttaaaaatc attttaaaag catcatgtca tttttagctc aaaatacttc agagaattta 50700
ttttatttta ttttttttgg agacagggtc ttgctctgtt gcccaggctg gaatgcagtg 50760
gtgccatcac ggcttgctgc agccttgacc tcccaggcta aaatgatcct cccacctcag 50820
cctcctgagt acctgggacc ataggcatgt gccaccacac ctagctaatt tgtttgtttt 50880
tttgtagaga tggggtcttg agcccaggct ggtctcgaac tcctcagctc aagggatcct 50940
gctgcctcag cctcccaaag tgctgggatt acaggtgtga gccacaaccc ccagcccaga 51000
gtctcctttt tactaacggt gtacaacata aaattcaaac tctaacatgg ttttacatct 51060
ggcccctacc taccttttgc ctctccttct ttgtcacata ctccacctgt tcccatgcac 51120
tttagactca agtaatgaaa aacagcttgt attgctagga acaggccgca ttctttcatg 51180
gtctgacttt atacacactc tcttgtggca acctagaaca cctgtctata ggctctctta 51240
catcaggcca taccctttct gtgaaatttt taatctgtaa tattctactg aaactttacc 51300
tctctgaagc cttccctaat ctcctcaggc ttttccattg ttcatattct gtcttgtaac 51360
agttatcaca ttgttaaagt cgttccccag taaactatga gacccttaac tgtggaaggg 51420
aaggcatctt tttaaccttt gtttttgtgc catacttagc ctagagcctg acattaagca 51480
ggtacttctc aaaaaaaaaa aaaaaaaaca cagggtagag acagataaca agggattcct 51540
gacacctacg ctgtagatag ctataacatt tcaataggaa tcttgggaat ctggggaact 51600
ggaagcagct gggaaagcac cggcatctga gccactcagt actcttccag gcttgtgtgt 51660
gagccttgcc accttcaggt attagcactt gaaatctaac ttctttatga agctccttat 51720
ttacttgcct tctcggtgaa aaaaaaaaac aacaacaaaa accgtttcct tccccatctg 51780
gtgccagcac tgtataattc ctaataagct tgaaaagata atgttggcaa tactttacaa 51840
gtttattgct aatgtttaac atttattagg tgcttgctgt gtgctgatct ctgtgcttac 51900
atatttttca tatatcactt catctatctt cacaacagtc cagtgaagta gatgccatta 51960
ttatcccaat ttcacaaatg ggaaaaatga gattcattga gataaattaa actacccaag 52020
gccatacaac tatagactaa gggggccaaa atttgaatct agtgtagatt caaattagag 52080
ctcattctct tattcactac tggggaatat tgcctggcca taactgaagt ccaaataaca 52140
gcatggttat aatatgggct ttaaaataat ctagacctgg attcaaaatc catttattgg 52200
aggcaagtga cttcacttct gatcttcagt tttctcatat gtaaaatgat aatatctacc 52260
tcaaaagtgt tactgcccac ccatgtacat ggtacatact aaaaaagcaa atgttagttc 52320
catttgccac ttctacactt tatgtgaacc ctgggggtaa tggtttgtac agaataaggc 52380
ctggcatgag aagacaaaaa ccatctgaca aataaaaaag ctgtcattct gtctaccaga 52440
atgtcaacca gtgcctgcct tccaggatca acaagtgttt tattaccata atcacattta 52500
ttctcttaat gaaaagggtg tgtcttgagt atttaatagt taattaccca taaatatact 52560
acagtagaat aaggaataaa accagtgatc tgtctactat agtaactagg tttctttctt 52620
ggtaatactt agggaacata tgagggttcc ctgtgggttg ttatttatta tataaaatag 52680
ttgctctggt agttccataa tagagacctg tcagtgccat tcagcagaga aaaatcataa 52740
acacagctgc tgtttttgtg tggcttgtgg ttttggtttt gttttcattt gaactttttt 52800
atgcaggcat gtcatcattt aaaagtagtc atttggcgtt ttcccttgca ttcttcagat 52860
tttttgtagg cttaaaaaaa tttaagtcac ttctataatt gttcatacag attgatccat 52920
ctggtctttt tactagccaa tgaaattttt gacatgtagg aaaaaggaca attattttaa 52980
attctataat ttcagtggat ctcttttata agtttgaaga aaaatagttt caactatcaa 53040
aaaatatttt tcttatattc ttcattgttt cctgttaatt tctgtatttt cgtgggggct 53100
aaaaaggcta ataatttctg ctattcctac tcttcacatc ctttgtgtgt tataactctg 53160
aagcatacca taattatttg tttgcaacca agaattggta cagcataaat gtctaatcaa 53220
attaggccct cttgctctct ttaagtcaca ctggctatga ggtggaggtg gattataggg 53280
ggcaggcatc aattcaggga gaccatttag gcctttgcag tggtccagac aagaaatatt 53340
gatggccggc ccaaggtact aagagtggta tttgaagaat gtagacagaa taaagagaga 53400
attaacgaag cttgttgatg ggttagatgt tgattggtgt gagatggaga gaggagtcag 53460
ggatggcagg tttcctctct tctttcttgt tgtgtttgtt caactcttgc ttatcttttt 53520
tttttctttg ttttttgatg gagtctcgct ctgtcgccca gactggagtg cagtggagcg 53580
atctcggctc actgcaacct ctgcctccca ggtttaagtg attctcctgc ttcagcctcc 53640
tgagtaggtg ggattacagg tgcatgccac cacgcccagc taacttttgt atttttagta 53700
gagacggggt ttcaccgtgt tggtcaggct ggtctcaaac tcctgacctc gtgatctgcc 53760
cacctcagcc tcccaaaatg ctaggattac aggtgtgagc caccatgccc agccacttat 53820
ctttaaagga ttaagtttat gtttcctact atgggaaacc atcccacccc aaacttgatg 53880
accgcattat gtgcttttat agaacctggc acttctccag gatagcattt attctgtttt 53940
gtaagtgtga atgtaattac cctacacaca gcatacacat aatcttcata ttctttgcct 54000
tgtcttgtga aggcaagggc catgtctatc ttattcgtca ttagattccc acatccaaca 54060
tagtcctggg gacagcacca atgcactttt ggtgcataag caaatagtgt catttatagc 54120
tcttacctac aatatctgat agactaatca aatatagtag gttatctggg cctttttgat 54180
tcatgtctct agcttaactt tcattttttt cttatttggt atctctcact ttgccttttg 54240
atatactctt acagtttcgc tcactgagta aaagaaaata taaacagcaa gaagtaaact 54300
tgtgttttat ggattttgat aacatcttct aaaagacccc ccaagattgt tgatgtctaa 54360
aaaaattaag ggccttcaac tcataataat acttaatagt tcttaaaata ttacaaactg 54420
attggaacat tgcactaaca gagagagtca tggatcttat ttatgtgtag attcatttca 54480
gtcagaagta ttaggactgg tttatttgag aaagtaaata gatcattaca aattcatcgt 54540
catacttcaa ggaaaattca ttgatgacac tttctaatat tgtgactata tacctaaatc 54600
atactttaag aacagaatgt ctaagatatc acctagataa gaatcaatac aaaaagaaaa 54660
aggaaaatta caaagattga tttaagaaag acaaaagact aagccataaa atttctcatt 54720
attacaggtt gagggcaggg agtgaaaaag gaaaaggatt tgacttctct aggcatggtt 54780
ttacttattt taaaataaga gcagtggacc catgatctga aagattgttt ctggcctaaa 54840
ttctgttttt ccgtaagata gaagagaatg ataaaggtga tatgcaatgg gaattttggg 54900
ttgaattgca acttactttt cattcttccc atagcctcat ctctgtcttg atgaaacctt 54960
agagaatcca ctcaaatata gtgttttctt aaatgacttt attaaattta attaaataca 55020
aatggttttt ctaatctctg ctgaaataaa ttctttgtag cctaatttag agcaacagtc 55080
tagattagaa tacttaagat gaattattac tacttagcct aatcaagtca aactatggaa 55140
aatgagtttt tacattttag cagtgttata aatgtattct tctgtagttg tgtctctttt 55200
aacatatgtt ttccttcttt gatttaggtt tctgctttgg gacaaccata catctaattc 55260
cttaaagtag ttttatatgt aaaacttgca aagaatcaga acaatgcctc cacgaccatc 55320
atcaggtgaa ctgtggggca tccacttgat gcccccaaga atcctagtag aatgtttact 55380
accaaatgga atgatagtga ctttagaatg cctccgtgag gctacattaa taaccataaa 55440
gcatgaacta tttaaagaag caagaaaata ccccctccat caacttcttc aagatgaatc 55500
ttcttacatt ttcgtaagtg ttactcaaga agcagaaagg gaagaatttt ttgatgaaac 55560
aagacgactt tgtgaccttc ggctttttca acccttttta aaagtaattg aaccagtagg 55620
caaccgtgaa gaaaagatcc tcaatcgaga aattggtatg atacaatatc ctattctaaa 55680
atgcaaataa ccataaagct taactgttgt ccctttctaa aatatttctg tctaaaccaa 55740
taccttcgta atcttaaata gctttctaaa taaaaatcat aaatctaaag tatgttttac 55800
tatcgaacta tggaactatt tttaacacct tgatattatt ccataaggtt ttatttaaga 55860
aatgtcattt gtgggatgac ttagatttgt tatatctcag tgttgttatt cttttaaaaa 55920
tgattgatag gaatgtttgc tgcctttgct ctaaattgct gaatatatta ttttttatat 55980
attaaaaata ttcaggactg tcaactttta atatatatgc attcatcaaa aatttgtttt 56040
aacctagcgg tacttttttt actttattgt gatcttccaa atctacagag ttccctgttt 56100
gcaaaaaaaa catgttcatg ctgtgtatgt aatagaatgt tatattcttt atgtaatttt 56160
attaaaggtt ttgctatcgg catgccagtg tgtgaatttg atatggttaa agatccagaa 56220
gtacaggact tccgaagaaa tattctgaac gtttgtaaag aagctgtgga tcttagggac 56280
ctcaattcac ctcatagtag agcaatgtat gtctatcctc caaatgtaga atcttcacca 56340
gaattgccaa agcacatata taataaatta gataaaggta agaaaatgac taatctactc 56400
taatcattac tatagtgcag tcttctacct gtgtctatat ctttgtatag tctttttttt 56460
tttttccagc tagatagtaa gcttcttgaa ggcagggact gcttatactg acaagatata 56520
gttgagtgct aaatagaaat tatgtacaat caatatttat tggttgaatt tttgtgtgaa 56580
tatgatactg atttcttggt aaattgtcta taaaacggaa gaagtatgag tttgaaattt 56640
actatttttt aggattcaga attagagctg attatctttt cataaataaa aactataaat 56700
agaaacattt tatgaaattt tgggaaaact ttatacattc ttgttattat atatcataaa 56760
tacaccagaa aaaaataagt aattttctta agtattaaat gcagtaattc tgatcatggg 56820
tgataatata tagggagatt tttgatattt aatatattag tttctagaat taagggaaca 56880
agaaactaaa ctatattgtt ttcaaaatgc atgtcattgt atcagataaa tatctatatt 56940
tttcagggta acagtaaaat tatcaatttg agttaactct cacacactat taaatatcaa 57000
attctgttag tagaataagt taagacatct tattactatt cgtatttttc aaagtagttt 57060
aatgcaacat aagatctttc aaaattcttt tctattctag catatatttt aatgctcttt 57120
tcattttccc gaacattctt tgtgaaaaat tttcaacata tagacaactt gaaagaaatg 57180
tactgtgaac aaccaaacct ctctaaatag tttgtcttcc cgttttcttc atctttctct 57240
tttcttcttt tttggactcc tggcttaatc ttaaaaggag aaaattagac aatgcatttc 57300
ctctcccctc gtaattttct tacctttcct ccctcacatt ttctgtcatt ctaattgaac 57360
atctttaaac ctccattggt tctttcttta cttcccatag ttaccaaaaa cttccacctt 57420
aggcactgtc aaacctttga gaccatcatg aatcactatt cataggggca gtacccatga 57480
agtatgtcat acagtttaga atggaaatta gcttggtctc aggtacttgt gacccacata 57540
tcacagtttt gtgtgcttgt cataaaacat gagatttggg aatgatctgg cagcccgctc 57600
agatataaac attttctgtt tctacctgat atttacctag ttttaattgg gctgattaaa 57660
aagcatttct gatatggata aagtaatgat agtgaatact tgttgaaatt tctcccttga 57720
aaaatgaaag agagatggtg attgcatcta atgttttcct gttatagggc aaataatagt 57780
ggtgatctgg gtaatagttt ctccaaataa tgacaagcag aagtatactc tgaaaatcaa 57840
ccatgactgt gtaccagaac aagtaattgc tgaagcaatc aggaaaaaaa ctcgaagtat 57900
gttgctatcc tctgaacaac taaaactctg tgttttagaa tatcagggca agtatatttt 57960
aaaagtgtgt ggatgtgatg aatacttcct agaaaaatat cctctgagtc agtataaggt 58020
gagtaacaag tttcaaaata ttaattttta atttaaaaag taatcacatt gaggatgagt 58080
atctgtattt tttttttttt tttgagacgg aatctcactc tcgcccaggc tggagtgcag 58140
tggcgcgatc tcggctcact gcaggctctg cctcctgggt tcatgccatt ctcctgcctc 58200
agcctcccga gcagctggga ctacaggcgc ccgccaccac acctggctaa ttttttgtat 58260
ttttagtaga gacaggtttt gcaccatgtt atctaggata gtcttgatct cctgacctcg 58320
tgatccactc tccgtggctt cccaaagtgc tgggattaca gacgtgagcc accacgccca 58380
gccaagtatc tatttttagg atatacttct tgataagtaa tattagtaaa tagcgtttgt 58440
aagcttattc ttttaattct gtgattaatt cgagaggctg aaaatgttgg cagttactcc 58500
agctcccaaa tatagatatt ccatggggtt gttgtttttg ttgttgtttg tttgtttttc 58560
gagacagggt ctcgctttgt ctctcaggct ggaatgcagt ggtatgatca tggcttactg 58620
cagcatcagc ctcccaggct caagcagtcc tctcacctca gcctcctaag tggctgggac 58680
cacatgcgtg tgccaccatg cccagctaat ttttgtttgt ttgtttgttt gtttagagac 58740
agagtctcat attgtccagg ttggtctcga attctgggca caaacaatcc tcctgccttg 58800
gcctcccaca gtgctgggat tacaggcgtg agccattgcg cccagcctat ttcgtgattt 58860
ttatcccctc caaccagtgg ctgtggaatg gaattgaaat agacatttca aaaaatccat 58920
gacctactgt taagatatac tattgatact ttcctactct ctttttctgt ttattaaata 58980
aatacctata agaagcaact acgtttgtgc caagcatatg tcgagtacta atttacataa 59040
ccaagtaaaa cctgggcctg gccttcaggt tgcttatttt ctagtggggc ttatgggtaa 59100
gaaaataatg tgtatatagt aacatttata ttaaaaatct cgtcttaact accatttcaa 59160
aattcagacc agtatatttt aacatttttt gtaaatatcc ataatgttac tggtctccac 59220
tatttgtggt tttttgtttt aattttagca aaactaatgt ttctcaggaa atgtttggac 59280
aaaaaagcaa gtgaacagca gcctttggat gggacatcag tatgacttaa tagattgaat 59340
gacagaggcg tcctaagtga tattactttt ctgttatcat atacaatgtt ttcataatga 59400
gtatcctgtg atccttgttt tttttttttt ttttttgaga cggagtcttg ctctgtcgcc 59460
caggctggag tgcagtggca ggatctcggc tcactgcaag ctccgcctcc cgggttcacg 59520
ccattctcct gcctcagcct cccaagtagc tgggactaca ggcgcccgcc actacgcccg 59580
gctaattttt tgtattttta gtagagacgg ggtttcaccg ttttagccag gatggtctcg 59640
atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg 59700
agccaccacg cccggccgtg atccttgttt ttaattcctt tttttgcctc cagttaaggg 59760
tagaactaca gtttcaaaag ttgaccttaa tttttttctt tcgtgcaatt tatattcaga 59820
agtgtttgat tgatcttgtg cttcaacgta aatcctaaat gttagtattt taaatgttat 59880
aggaactact agtaaatgtg gtctataatg tttaattttt tatcaccttt gcagattaat 59940
atgtagtcat aatactctga catgttactt ttaaaatgaa aaaccttaca ggaaatggct 60000
cgccccctta atctcttaca gtatataaga agctgtataa tgcttgggag gatgcccaat 60060
ttgatgttga tggctaaaga aagcctttat tctcaactgc caatggactg ttttacaatg 60120
ccatcttatt ccagacgcat ttccacagct acaccatata tgaatggaga aacatctaca 60180
aaatcccttt gggttataaa tagtgcactc agaataaaaa ttctttgtgc aacctacgtg 60240
aatgtaaata ttcgagacat tgataaggta aagtcaaatg ctgatgctta ttattttata 60300
gaaattattt tagataacct ttttcttgca ctatacagta atctgttgac ctgtagtatg 60360
ttttcagatg gttaggagaa catccaaatc tccgaatgta aaaatatatc aagaatttta 60420
cttgagcttc catctacctt agctattata cagctcacag tcctttgtta ataattctaa 60480
tattcacaat tctagctctt aaaatcaaaa gttttacaga attcgtttgg cagaaagacc 60540
tgggccaacc ttaagtgagg gtttttataa tctttattaa ccccacttag tataaaattc 60600
cggtatctta ttaaagaaat attaatgtct ttatgaggta ctgcttcacc agctaaggaa 60660
gtagtattta gtaagtacgt gtaccaattt agctttctaa aatatggaaa aactctgaat 60720
tacatacctc ccttaagggg attgtgggcc tatatttatg ttttagtagt ctgatgtctc 60780
cattgttatt agtggatgaa ggcagcaact aattttggtg aagactctac atcagtatta 60840
acgtgttaca tatgtgaaaa aaaggagaac caagctatat ctgaacaaaa attccgtggt 60900
tttatatttg agtctatcga gtgtgtgcat atgtgtatgt tgagtgtata cattagtata 60960
tacctacttt tttcttttag atctatgttc gaacaggtat ctaccatgga ggagaaccct 61020
tatgtgacaa tgtgaacact caaagagtac cttgttccaa tcccaggtaa ggaagtatat 61080
agatttatat ttccaaaggt tatattagtg tttagcagta tgatccataa aagtagtata 61140
tttttttaga ccagcctggg caacaaagca agaccccatt tctacaaaaa gtttttctta 61200
aaaattagct aggcactggc caggcacggt ggctcatgcc tgtaatccca gcgctttggg 61260
aggctgaggc gggtggatca cgaagtcgga gtttgagacc agtctggcca agatggagaa 61320
accccatctc tactaaaaat aaaaaaacat tagccgggcg tggtggcggg cacctgtaat 61380
cccagctact tgggagactg aggcaggaga atcgcttgaa cctggaaggc tgaggttgca 61440
gtgagctgag attgtgccat tgcactccag cctgggcaac agagcgagac tccgtctcaa 61500
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaattagct aggcacagtg gcatgtgcct 61560
gtagtcccag ccattaggga ggctgagaca ggagaatagg agaattgctt gatcctggaa 61620
gttccaggct gcagtcagct atgatcgtgc cactgcattc cagcattagt gagacctgat 61680
ctcaaaatat atatatattt tacatcatta gctttataca agctatatat taataaatta 61740
ccagaaatgt acatatagac cagcaagact ttctgtcaaa tgagtatcag tcacaggatt 61800
attttattga ttctgtctaa agttttatca gaatagtttc tgattgtctc ttttcattgt 61860
atcaaagaga gaacagagta tggttataat tttatgctaa tcattcccca cattagatta 61920
aaaacctagc attttattct tttcctgtct ccatcatcat tcacatgaag gagaagtaag 61980
agttggcaag caactccata accaaactac cctgaggcag tttccttcaa atcactccca 62040
agaatagata tttatggctt tcaaataaag ggtctttggt agcaaattaa tttgttagtg 62100
ggagagggag ttatggggaa cattttaaat tattactgcc tggatgtgat gaagaaataa 62160
aaagtagtat aatccaatag ctgactatcc tgcatttctt tgcttctctc tatacagtca 62220
tttgggaata agagtacccc tgaacgtaat agcagtaata tttcaagaga actcaaattg 62280
ttattggact ttatgataaa ataacaatag agctaactag tgactcctcc agaagtaaat 62340
ctcataatga atttagactg agttctaaga cattcaagaa aaagttctgg tcttgttgct 62400
aaagatggcc acccttttag agcctaggta aggttaaaag agatggtagc cttgtctgcc 62460
acagggaagg aagatagttc ctcagcctac ctaaaccact gtaggtcaga aaacgtatca 62520
ttcaggtcag aaatgagatt gtgacaacaa acaacttcag gatctttttt tttttttttt 62580
tttttttgag ttgaagtctc accctgtggc ccaggctgga gtacagtcaa gtgtaagcga 62640
ttctcctgcc tcagcctccc tagtagctgg gactacaggc acatgccact gcgcccagct 62700
tattttttgt attttcagta gaggggggtt tcaccatgtt ggccaggctg gtcttgaact 62760
tctgacctca ggtgatccca cccaccttgg cctcccaaag tgctgggatt acaggcctga 62820
gccatcatgc ccggccagga tctttttaaa ttcttgctaa aacaagagtt tatatcccac 62880
tcatactggt atgcctcaca ctgattagtg gggtggttgt agcaggaaaa gaaaaacaac 62940
atttgaggaa ataatagcca gaatttttcc aaatttggta aaaactataa acccgtcaat 63000
ccaaggagtt caacaagccc caagcaaaga ccccaaaata atactggata gaattatcct 63060
agctagctgt ttcaagtacc acaagttaaa ctagctttat aaaagtaaaa ggctgggcgt 63120
ggtggctcac gcctataatc ccaacacttt gggaagccaa ggcagatgga tcatttgagc 63180
ccaggagttt gagaccaccc tgggctatat ggaaaaacac agtctctacc aaaaatacaa 63240
aaaattagcc tgggatggtg gtgtgtgtac ctatagtccc agctactcag gagggtgagg 63300
tgggaggatc acctgagccc agggaggttg agactgcagt gagccatgat cgtactactg 63360
cagtccagtc tagggggcag agtgagaccc cgactcaaaa aaaaaaaaaa aagtaaaaga 63420
taaacttatt taataatata tgattaaaat gttgaaatgt tagtaaaata gctatttaga 63480
aaggactata tttgtcttta agcattctgt agtctaaaag gtgaagtatt tatggtagtg 63540
tgaaaattta agtaaacttt ttaaactttt ctgtgcttac aaaaacaaaa atcagataaa 63600
tgaatatgaa gttattaaaa agatagaaaa gtagatttta aaaattctta ctaaatattt 63660
gtttcaaatc tgtgcttctt ttatgctaaa ttagatgctt tatgatttct ttgtaaatgt 63720
tacaagtatc tcccaaaatc agagtcaatt tggactgtat acacacacac aaccattttc 63780
tagaaataaa gaacttaatt gagcatgtgt atatgtgtgt gtgtctgtgt gttgtgggat 63840
ggatggactt tagaagaaaa gagaaacatg ctttattttg ttagcatagg gctgaacaag 63900
tagatttgta ggacatagct ctcttagagt atagaacact tcttattaat ttatgagcac 63960
ttctaaagat ttaggaataa taaaaagtct ggtacattaa agtaatatat ctttaatttt 64020
tcttttcttt tttttttttt tggaggcgga gtcttgctct gtcgcccagg ctggagtgca 64080
tggcacaaac tcgactcact gcaacctctg cctcagcctc ctgagtagct ggagttacag 64140
gcgcccacca ccacgcccag ctaatcttgg catttttagt agagatgggg ttttgccacg 64200
ttggccagac tggcttcgaa ctcctgacct caggtgatcc gtccaccttg gcctcccaaa 64260
gtgctgggat tacaggtgtg agccaccatg cccagcctaa ttttttttaa atcattgcgg 64320
acttaagtcc cataatattt ttctctatat gtttctacaa ttatatgtgt tactgggcat 64380
ggtagtatgc gcctgaaatc ccagcaactc aggaggctaa gggaggctga ggcaagagga 64440
tcacttgagc ccaggagttc gaagctataa tgcactttgg tcatgcctgt gactagccac 64500
tgcacttcag cctgggcaca tagcaatacc ctatctctaa aaaataataa taataataac 64560
atttgttttt tcttttacct ttagaattct tgccacattt ccccatttta aatgtgtctt 64620
gtttctataa atagaccata tttttaaaaa tctttatcca tacttgagca aaaatgctag 64680
aataaatgga acttatttta ctgatgaagt ttattactta gttggctaat taaaaataga 64740
attgttatac tattttattg ttgattaaga attattttat ttataatcaa gattagacca 64800
gaatgataag acatttgaaa agtttttaaa attactatct aacatatgag cttctatcat 64860
gggacaattg ctattctaat tcctttgctt gtgttatctc atttaatttt atgagatagt 64920
tatcaacctt atgagggtag gtactattat tagtcccatt tcatagagga ggcaaaagac 64980
aaagcaaggg tcacacactt agtgaaaaag gggaaataag attctactcc agtctgattt 65040
ctgagcccat actctttatc cattgttata atgttttttt aaaatacaaa actgtttatt 65100
gtatgtggtt ctttacaaat atgttcacca aagacagaca taatttcaca tgtagcaccc 65160
agtaaattga gggaatttat cattaaaatt caaataattt tttatcttgt tcactttttg 65220
tagcagtgtt ttattcttcc cttatgaatg tgaagtttca ttacctttta taaaataatt 65280
attcttcaat tcaaatactt tatgtatcca tcattttatt tacctactga tttatttagt 65340
ggattccttt ggataaaact atattatgta taaaagtaac taaatgtaat cataatagga 65400
aatcttattt tacctttagt tttccttttg tttgactttt atgagcaaaa ttatatatat 65460
aaatatatag aaataataaa tatatattta tattatgtat atagtatatt atataatata 65520
tattataaat ataaataagt tttttagtga cgtatgtagc acacatgcat aaaagtatac 65580
aaatcataat tgtatagttc agtcacaaag taaataccca tgtcttctgc ttttaacaaa 65640
tgcacacatt tctgtggttt tattcctaca attggagctg ggtcacaggg aatacatatg 65700
ctcactttta ttagattatg ctttccaaat tggttgtaac aaattatacc ccaatactct 65760
tagtgtatga gatttcctat tactgcataa ccttaccacc ccttggcatc atcagtcttt 65820
atagtttagc cattcttatg tatagtgata tctccatgag attttaattt tcattttctg 65880
tatgactaat aatgactccc ttttcatgtt tattaactat ttgaatatga ccttataaag 65940
tgccttttcc aatcaatctc tttcctgttt ttcgtttggt tgatctttgt cttcgtgatt 66000
tgtaggagtc atttatatac tttgatgaag acttttcttg atgtattatt tttgctttaa 66060
aattttacat aggtggaatg aatggctgaa ttatgatata tacattcctg atcttcctcg 66120
tgctgctcga ctttgccttt ccatttgctc tgttaaaggc cgaaagggtg ctaaagaggt 66180
aaagtatttc agaaggaaca attatgttta cctttaaaaa ctcctgatta taccgctgat 66240
tgaatttttt cacaaattgg atgttatttt atatttaaga aaataataat aaacctattt 66300
ttaaaatttt aataaatgta tcatggaaga ataccttggg agagcttcag gaatttatga 66360
tgaatatgtt ttgagttctt attgatacca tttttaaaaa tgcaaagtga ctatataaca 66420
gggattgcat gcaaatatct catgcttgct ttggttcata ttttctattt ataattaaaa 66480
tacatgtaat ttcaaatggg gaaaaaggaa agaatgggct taaaccttga aaaatcaatt 66540
tttttttttt agatattccc attattatag agatgattgt tgaattttcc ttttggggaa 66600
gaaaagtgtt ttgaaatgtg ttttataatt tagactagtg aatatttttc tttgtttttt 66660
aaggaacact gtccattggc atggggaaat ataaacttgt ttgattacac agacactcta 66720
gtatctggaa aaatggcttt gaatctttgg ccagtacctc atggattaga agatttgctg 66780
aaccctattg gtgttactgg atcaaatcca aataaagtaa ggtttttatt gtcataaatt 66840
agatattttt tatggcagtc aaaccttctc tcttatgtat atataatagc ttttcttcca 66900
tctcttagga aactccatgc ttagagttgg agtttgactg gttcagcagt gtggtaaagt 66960
tcccagatat gtcagtgatt gaagagcatg ccaattggtc tgtatcccga gaagcaggat 67020
ttagctattc ccacgcagga ctggtaaggc aaatcactga gtttattaag tatcaattat 67080
aatctgtgga tttaggtaga tactttctct atggaaaagg atccatatat tttactggca 67140
tagatactat gaactctagg accaatattg caatagaatt aagttctcta tatgctaata 67200
tttttactgc acctctgctt ttttaaagcc ctagcttgcc ttcattcatt taacaaatat 67260
ttattgaatg ccgactatgt gtaaagcact gggaaaggca ctaggtaata aagtcatgaa 67320
ctaaacagac cttcattgag tatgcactct aactgtgaaa acagacatta agcagataaa 67380
agcagaaata taagattaca gttgaccctt gaacaacatg gatatgaact acactggtct 67440
acttatatgt ggattttttt caataaatat attggaaaat tttttggaga tttgtgacaa 67500
tttgaaaaaa acttggagat aaactacatt gtccagaagt atcaaaaaaa ttgaagttag 67560
gtatgtcatg aatccataaa atatgtatag atacaagtct attttatcat ttacgaccat 67620
aaaatataca caaatctatt ataaaaagtt aaaatttatc aaaacataca cacacaaaca 67680
cagaccatac atggtaccac tcatagtcaa gagaaatgca aacatatata aagatgcagt 67740
attaaattgt atctgcataa aattaactgt agtacatact gtactactgt aataatttca 67800
tagccacctc ctgttgctat tgtagtaagc tcaagcattg catatatcca cttaaaatgc 67860
tatgtaggct gggtgcagtg gctcatgcct gtaatcccag cactttggga ggccgaagcg 67920
ggtgaatcac ctgaggtcag agttcaaaac cagcctggca aacatggtga aatcccgtct 67980
ctactaaaaa tacaaaaagc cgggtgtggt ggcatgtgcc tgtaatccca gctactcggg 68040
aggctaagtt aggagaattg cttgaacccg ggaggcagag gttgcagtga gccgaggtca 68100
cgccattgca ctccagcctg ggcaacagag caagactccg tctcaaaaaa caaaacaaaa 68160
caaaatgcta tgtaatgctg atcatctcta catgagtact tcatcacttc agtaaattgt 68220
ttattgcagt gaaaagtgat ctctcacagt tcttggatat ttttcatcat gtttagtgca 68280
ataccgtgaa ccctgaataa cactatgagg gctgtaagga gtgcctctag tgatgctaga 68340
ggtactctca agaagcagag aaacgtcatg acgttacaag caaaagttga attgcttgat 68400
gtgtaccata tattgaggtc tgcagctgca gttgccctta tttcagacag acaactaatc 68460
ttgtaaacag acaacataaa ctttgtttgt ttttgttttt ttgagatggc gttttgctct 68520
tgttgctcag gctagagtgc aatggcacaa tcttggctca ctgcaacctc tgcctcccgg 68580
gttcaagtga tcctcctgcc tcagcctcct gagtagctgg gattacaggc atgcgccacc 68640
atgcccagct aatttttgta tttttaatag agacggggtg tctccatgtt ggtcaggctg 68700
gtcttgaact cctgacttca tgtgatccac ccgcctcggc ctcccaaagt gctgggatta 68760
caggcgtgag ccaccgcgcc cggccaaact tttttttttt aataagagat ggggtaggtg 68820
gatcacacct gtaatcctag cattttggga ggccgaggcg ggtggatcac gaggtcagga 68880
gttcaagacc agcccggcca atatggtgaa accccgtctc tactaaaaat accaaaatta 68940
gccaggcgtt gttgtacatg cctgttagct actcaggagg ctgaggcagg agaatcactt 69000
gaacctggga gatggaggtt gcagtgagcc gagattgcgc cgctgcactc cagcctgggc 69060
aacagagtga gactccgtct caaaaaaaca aaaaacaaga gagagatggg gtctcactgt 69120
gttgcctggg ctggtctcga actcctgagc tcaagtgatc ctccctcccc tacctcccaa 69180
agtgctagga ttacaggtgt gagccatcat gcccggccaa aagacaaaat aaatgtatag 69240
tatcagtaaa tacagtacag tactgtaaat gaattttctc ttccttatga ttttcttaat 69300
aacattttat tttcactgtc ttactctatt gtaagaatat aatgtatagt acatatacca 69360
agtaagtgtt aatcaactgt ttatatttct gttaagactt ccaatctaca gtagtcattt 69420
gtagttaagt ttttggggag tcaaaattta cacatggatt ttcagttgta caggagatca 69480
gttgccccta tcccctatat tgtccaaggg tcagctgtat aaatcacatt aagtgccagg 69540
aaggaaaaaa caatagtgag ctaagaataa ctaactgagg atttgtgggg aaaaggcaaa 69600
tatatatata ttgggttcag gaaagacctc tctgagatga taaccttgaa gttgagactg 69660
aagtacagct atacctctga ggtattgtga gtggtctagt tctagaccac tgtactaaag 69720
cagaaatcac aatagagtca caaatgtttt ggtttcccag tgcatataaa agttctgttc 69780
acattatact gtcatctgta aagtgtgtaa tagtctgtca tctgtaaagt gtgtgatagc 69840
cttacgtcta acacaacaat gtacatactt taaaaatatt gctcaaaaat gctgatgatc 69900
atgcaaggct tcagcaagtt gtaatctttt tgctggtgga gggtcttgcc tcagtgttga 69960
tggctgctga cttaccaagc tggtggttgc tgaagtaacg ttagcgtggc tacagcagtt 70020
tctttaagac gacagtgaag tttgccacat tgattgaccc ttccttatgt gaaagatttc 70080
tctgcagcat gtgatgctat ttgatagcat tttgcccaca atagaacttc tttcagattt 70140
ggagtcagtc ctctcaaaac ctgacgttac agttaaccag ctgcattagc ccctaacaag 70200
agagtcagcc tgaagctttg aagccaggca ttaacttctc ttctctagct gtgaaagtcc 70260
tagatggcat cttcttccat tataagactg tttagtttac attgaaaatc tgttgcttag 70320
tgtagccacc ttcatcagtt atcttggcta gatcttctgg ataacttgca gcagcttctc 70380
catcagcact tgctgcttca cagcttcttt tttaaacctc ttataccaac ctctgctagc 70440
ttcaaacttt tcctctgaag catcttcgtc tctctcaata ttcatagaat tgaaaagagt 70500
tacggccttg ctctggatta ggctttgact taaggaaaag ttgtggctgg tttgatcttc 70560
tatctagacc actaaaactt tctccatttc agcattaagg ctgttttgtt ttcttatact 70620
tcattcactg aagtagcact tttaattttc ttcaggaact tttcctttgc attcacaact 70680
tagctgtttg gcaccagagg cctagccttg gcctgtatgg cttttgacat gcatttctca 70740
ctaaacttaa catttctagc ttttgatgtg aagcaagaga cgtggcactc ttcctgtcac 70800
ttgaacactt agaggccatt gtagggttat taattggcct aatttcaata ttgttgtgtc 70860
tcagggaata gggagtcctg agaggaggaa gaaagaggag caaaggttgg tcggtgaaga 70920
agtcagaaca tgcaacactt atcgaataag ttcaccatct taattggctc atggcacccc 70980
caactgcatc agagtaacat caaagatcac tgatctttga tcacagatca tcataatata 71040
taataataat gaaaagcttg aaatattata agaattacca aaatgtgaca cagagacaaa 71100
aaatgagcca tgcatttgga aaaatagtgc caggagactt cctttacata gggataccac 71160
cacaaacctt cagtttgttg gaaatgcaat atctgtgagg tatgataaag caaagcacaa 71220
taatacaggg tacacctgca caaatatatt gttagttgag cttggaagca gagaaaacag 71280
caggtcttca ccatgttatc ccaggttccc caggaaagag cgtatgtaag atggaattta 71340
aatattgatc tagttgtcta atcttggcca tagcttttga accacagtat aattatctag 71400
gttcaagaac cattaactct ccctgatttc tcaagggcaa agatgtcaat gccacgagaa 71460
gatgtttgtg ttcattggtg tttccaaata tattactttt tctttggctt tgttggctat 71520
agataaacca gccaatgaat tttgggccaa gaagtccaaa acacccctat cccattaaca 71580
gtaacagcag catcaagagg cagcctggta tattgcactt aggaaattta ttgattcata 71640
gctgtgttct cagtaaggcg tttaccacta cttttcggaa aacaaattat cttttctgca 71700
tatatatttt tctgcattta aaagatacga gtctcttttt tgagcagttc tctttgtaag 71760
aattgatatt tgatgactgt attctttctt aaaagaaatt ttatttcaaa gaaaagaaat 71820
ttgcttattt tatagcagaa taaaacttct atttttcagt tacaatttgt atctattgga 71880
aacttttgta aatctaagat acgacatgga atcttagttt ttctgtatct taaatatttt 71940
actatttcat catcctagaa attacttcat ccatattcat tatttccaac tatgctaaaa 72000
aagactaaaa taatatgaaa atataaaaga aggatagaat agcctagaag gacaataaaa 72060
tagtgaagta aatcatgatg ttacatcatc cttcagtttt cttattgcat tgcccagtgt 72120
cttgcatcat ctttccagaa gtatagaaga agtctgcaga cactgtcttt gtaatttttt 72180
tgtttggttg gttggtttct ttcaggcttt cattggacac ttgagaattc agaatttttc 72240
acttttcacc cagaatgatg acagatgaaa actgaccaag gaagatattt cacaagcatt 72300
agacaaatca taatatgaat gtagatagat agtagcagcc tagagcagag tttcccaacc 72360
tcagcactat tgacattttg cgccaaataa ttctttgttg taggagccat cctgtgtgtg 72420
caatccagga tgtttagcat ccctgtcctc taccctactg caggccagta gtgccatcct 72480
gctaagttat ggctatcaaa aatgtctcca gacattagcc aaggttcctg ggtggtcaag 72540
gggacacaaa atcaccctag ttgagaacca ctactctaaa ctctaatcat ggtgaagttt 72600
attatataaa tgaaatgtca gatgacaaca cctaaactgt ctctcagtta tcttaagtct 72660
tctcaaactc aggataatga tgagtaaaga atatatttct aacaacaaaa aggaaatttg 72720
atagtatttc taaagacaaa aaggaaattt gtattcacat tcagttagtc attccaccag 72780
aatgacttca tcacacaata ttttgtgaca agaacctgaa cagcctgttt tacagtattc 72840
ttttcatctt ttattatatg caccaaaatt tttttttaaa ttttcttgaa cctctaaatc 72900
tacgttaaaa atttacctga tacactttct aaatggacaa atgccgaagg tagctgtgta 72960
tacaaatgtg actagaagga aaaagatgat atagaaataa aataactcct tgagttgatc 73020
attctgattg gcatttatag agtagaaatg ttttgtaatt acagaggaaa aaagatggcc 73080
tttccttcaa cagttatgag ccgtcagaat tttcaaaaat actgcatttt gacaatgtag 73140
tttctagttt gacaatgata tatttatctt caaaaccagg aaaatgtaga taagaatttg 73200
gttttataat atttaaattc ttattaaaat gtctaataaa attgttttcc ccatcacttt 73260
attcttctgt aagttatttt atatttaaaa tgtaaacaaa taaaaataag taaataaaca 73320
gtagcagctt cttttcctga taaatcgagg attgagtatg tattatctct ttcctggact 73380
actggaataa cctctccctc cttccacaga gaagccataa taatctttat gaaatacaaa 73440
tcaaatcatg gtattcattc tttaaatagc tatcaataaa aataaaatcc caactttata 73500
ccctgttcgc aaattttacg tggtctgaat tcagcttaca tttcttcttt cccttgtcta 73560
ttgcccatca ggctcactgg ctttattcct tcacaccaaa ctagttattt ccggggtggg 73620
aggaaggctt gcagtgtttt ctccatctgc aatagtcttt cccaaatctt agtgtggata 73680
aaggttcctt cttgttactt gaatcacaaa tactatgttc tcagtcattc tctgttacat 73740
catccagagt acattatatc aattttccaa tatttttatt tatttgattt cccactataa 73800
cagaggctct gttagtgcag ggtcttttac tattttgtaa tcccaacagc aagaacaaaa 73860
caaggtacat agtacatatt taataaatac ttgttgaaca aatatgtgcc ggtaatattt 73920
cttcatgctg ctgaataagt taacagcata taaacacata caaaccaagt ggcatggatg 73980
tctgctttca tttttagcct tttaaaaata tatgtaaccc atcctaaggg gtttatattt 74040
gttttgcata atacattaat atgtactcat tattcattac acagttaata tatctatatt 74100
tgcagggaat atacattgct tggaattata caaaaaaata ttatttttcg ttttctaata 74160
ttcaggatac agtgttttaa tgggggtgtt tcttcattct ttttttctta ctggttttta 74220
ctttttaaat ttgaaagctt tgcagggatc ataaggatct gttcaggcaa agaacatgaa 74280
agggtttaca tttttatcat tttagtgttt cttattctct atatcaaaaa cattcacaga 74340
taagttaaca agatcctcat caggaggaaa agtaaattgt tcactaccat cctctagtat 74400
cctaatctgg tcttgttgtt ggctaacttc agcagttact attctgtgac tggtgtaata 74460
ttaaccaaat aaattactgg atttgttcta caaatattat gtcttagatt ggttctttcc 74520
tgtctctgaa aataaagtct tgcaatgaaa ataaattatt ttacaacagt taattagcaa 74580
tgtaaaattt attgaaaatg tatttgcttt ttctgtaaat catctgtgaa tccagagggg 74640
aaaaatatga caaagaaagc tatataagat attattttat tttacagagt aacagactag 74700
ctagagacaa tgaattaagg gaaaatgaca aagaacagct caaagcaatt tctacacgag 74760
atcctctctc tgaaatcact gagcaggaga aagattttct atggagtcac aggtaagtgc 74820
taaaatggag attctctgtt tctttttctt tattacagaa aaaataactg aatttggctg 74880
atctcagcat gtttttacca tacctattgg aataaataaa gcagaattta catgattttt 74940
aaactataaa cattgccttt ttaaaaacaa tggttgtaaa ttgatatttg tggaaaatca 75000
tactacattg gtagttggca cattaaatgc tttttcttac tctgaattcc tgatatgact 75060
ttctttagga ttgtttaaaa tattctagta gttttaggtc aatttagatg tgatttagtt 75120
ggtctagata ttataatttt taggggttcc ctttcatttt tcttttttct tacgtttctt 75180
caaatagtat aatgccttat tttcatttat gaagaaatta ccctgctgtt ggtgatacgg 75240
gtatatttaa ataaaccagt tgcagtgcat ttctgcagaa agtccattaa gacataaatt 75300
ttgtccagta actacagtag aagtggtgac tctatgattc attcatgttg cataagtagg 75360
tgaaaaatat gagctatatg aagagtggta taacatatat tcataatttt tcttaactgt 75420
taactaaatg taagtactta taatccattt gcattttcct tttgtgttct ttgccattat 75480
aactgtgcct aagtatatat gtaaatatat ttccaactat agtgttaaac actgatgtct 75540
tttgaatttt aaaaaagcta gtaatgtaag aagtttggga cttcttaaga agattcatat 75600
ggagaagtta gacatgtcaa ccttttgaac agcatgcaag aatgtttatg tttattttgt 75660
ttctcccaca cagacactat tgtgtaacta tccccgaaat tctacccaaa ttgcttctgt 75720
ctgttaaatg gaattctaga gatgaagtag cccaggtaaa tgtatgtttg agattactag 75780
ataactgttg tacaaattgg tatgtcactt aaattgtttt ctctcagaaa gtccacataa 75840
ataaatgaaa tagactaata gtaatatagt gtagaaaaaa acacccttaa cattatttcc 75900
atagataaaa ctaattagaa ctgtaaattc taaggagatt atttatctaa actaatttta 75960
aaatcagaag ttaaggcagt gttttagatg gctcattcac aactatcttt cccctttaaa 76020
tatgatttat tgtctttctc atacacagat gtattgcttg gtaaaagatt ggcctccaat 76080
caaacctgaa caggctatgg aacttctgga ctgtaattac ccagatccta tggttcgagg 76140
ttttgctgtt cggtgcttgg aaaaatattt aacagatgac aaactttctc agtatttaat 76200
tcagctagta caggtaaaat aatgtaaaat agtaaataat gtttaattac aataataatt 76260
tattctagat ccatacaact tccttttaaa aaacctactg cactaactag ttttatgctt 76320
aaaaaaaaaa attattacca gtaatatcca ctttctttct gaaaaaattt tctttagatc 76380
ggccatgcag aaactgaccc tgatttgttt ttttggaatc acctaggtcc taaaatatga 76440
acaatatttg gataacttgc ttgtgagatt tttactgaag aaagcattga ctaatcaaag 76500
gattgggcac tttttctttt ggcatttaaa gtaagtctaa ttattttccc attaaattct 76560
taaggtacat attacttgct ttcttaatag atttataaat atgtattact tatatacttt 76620
tgtttatgtt tggctggaag agttttccat actaaaagta ttttgtacca gtgatgagct 76680
tctcaacttt tgctctttga aatttaaaaa gcagtaaatt caaaactaaa ttttagtcat 76740
gaatgagagc ttaaatattt ttaaagattt ttgttctact taagtcaaat tttctaggtc 76800
cagatgaata ttgctgtagg tttcactgtg tgtatggatt acaatatccc caaacaaaga 76860
aaaaaatgtt ttaccttgaa attcagaaca atgtcaaact cccgtggttc ttactgaaaa 76920
acaagctaat taagaataaa aaatgttttg tagaatgtga tatatgtagt actcaaaagt 76980
tacaggtcat aaaccatata acttttcata aatttagaag cagatttata tctaatatga 77040
tattttaagt gttaaaattt aataatggaa cccagaagtt aagttgaaaa caagaagcat 77100
aggcgtgtgt cagaagagtc aaacagcatt cactgagcgc tttgttccct ccctcttcat 77160
ttgattattt ttgtgctcaa tttccttttt tcatgttttt atatcttgta ctgagattag 77220
tcaatgaaaa ctagttgaaa taaacctaaa aactagatgt ttatttaatc acatattcag 77280
gaactacctg aaactcatgg tggttttgtt tctaaattac aggttttgaa taattttatt 77340
attagtatga ttgtaacatt tattggattt caaaaatgag tgtttaaatt gtttagcaaa 77400
gattatttgt atactgattt aagactatat atatatattt ttaattttgc acgattcttt 77460
tagatctgag atgcacaata aaacagttag ccagaggttt ggcctgcttt tggagtccta 77520
ttgtcgtgca tgtgggatgt atttgaagca cctgaatagg caagtcgagg caatggaaaa 77580
gctcattaac ttaactgaca ttctcaaaca ggagaagaag gatgaaacac aaaaggtgtg 77640
tgactctagt ttgtgtttga gactcttttc actgcagtgg ggcagagttg tttagaagcc 77700
cagtgtatat acagatcatg gtccttggaa tcaagcagat taggatttgg aaccaagttc 77760
cactgcctct cagctgtgta gtgttagaca cgtcatgcag gctctcagga ctcattttct 77820
ttgtctgtaa aatggaaata atacctgctt cataaggcca ttgtgagaat taaattacac 77880
gagatatgca aagaacctat cacaatcctt ggaacataga aggtggccaa taaatgttag 77940
atccctttac tttcccttcc tttctcttat tcaggtccct aagtatttac agtgattatt 78000
tccttattct gtcatttatt gtctctcagt aatgaccctg aaaatgagtg gaaagaagtt 78060
agtttttaca tttccaagtt taaaatggat ttcgagtcac tcagtaaata tatcacactc 78120
tagtcatctg ctgtctagct tagtataact aagagtagga aatacaatgt aaactttttt 78180
tttttttttt tttttttttt tttgagacag ggtctggctc ttttgcctgg cctggaatgc 78240
agtggtgcaa tttcggctca ctgcagcctt gacctcctgg gttcaagcca tcctcccacc 78300
tcagcctcct gagtagctag gactatagga gcatgccacc acttccagct aatttttgta 78360
tttttagtag agacagtgtt tcgctttgtt gcccaggctg gtctccaatt cctgggctca 78420
agcagtctgc ccacctcggc ctcccaaagt gctggaatta caggcatgag ccactgtgcc 78480
tagcccaatg taaacttttt tatgaccttt tcctacaccc tattctttat tcaatccaat 78540
ccaccacatc ctaaattcac cacctcttac aattaaaagg aagctcattc ctcacctcta 78600
gtaaaaggaa aaaaaaaaga aaaatcgtat attagtgagt ccccaaagga cagagaatgt 78660
aagttagcag tactgaatga atttttccag catcttcatt actagtactt gaaggaaaaa 78720
aaaaaattaa aacaaagtta ttgtattaat gtaaatgtca tacagtgtga gttgatttta 78780
ttgaagtgtg atatataaat tcaaatatag gatggtagaa aataattgta ctctttctga 78840
tactggaatt tatgagcaag aagggtctag attgccctgg aagaacaaaa tttattgtat 78900
ttatatattg taactgagct gagaaaaaag aaactaaatt ttagatacat ttgtaaatac 78960
agatgttcct caacttataa cagggttata tcctgataaa cacatcataa gttgaaaata 79020
tcgtacaggc aaaaatgggc attttgtaga tgtgatggga tgcgaaaaca caaaacacag 79080
tatccaaaaa atgctggcca cacagtacgc tgtagactat tggtcgttta ccctcatgac 79140
tgcatggctg actgggagct gcggctcgct gctgctaccc agcatctcaa gaaaatactg 79200
tgttgcatat cactagccca ggaagagata aaagtttaaa atttgatgta tagtttctac 79260
tgaatgcatg taggaagaga taaaagttca aaatttgaca tataatttct gaatgcatgt 79320
tgctttcaca ccatcacaaa gttgaaaaat agtaagtcaa aaccattgta agttggagac 79380
catctgtgta ggcatttctt ctaagctgga gtttttatat cacaaattgg ctatgataca 79440
gtggattaat taggaacatg aaattcatta ctcagatcat tattggctta aatgagattt 79500
tgatagggaa ctaagattgc agtcatagaa acaagagcag ttactttgag tggctttgtg 79560
ttttgttgta acaatgagtg ataaaatata agaagcattg tgctaacatt agagttgtca 79620
gtgatagaaa tgcctttaca tgaacaagag ctatctagtc agtgatgatt agattttcta 79680
actattcatt tgtatataac aagaagaaaa aaacttattt aaattccagc atgaaaatta 79740
atttattata attcctagct cctaaccact ttttccccca ctcacatttt atattttcaa 79800
taggtgaaag tttcctaaaa taaaatccca gctattgcgt gataactcag cagtctgggc 79860
tctgatttga attgattaaa aagggatatt gttttgtagc cacatactaa aacctgaata 79920
tagtatgaga ctccatgtaa caaatgtttt tacaagtcct tttcccaaca atttctttta 79980
gcctcactag accactttca cccagcaaag agagtatgaa tgctgtgttt tcttaaaagc 80040
ctaaaagtaa ggttattaag ctaatgtaac atggtctcct tagtttttcc tctagaacac 80100
agatcagcaa gttttcttaa agggccagat agtaactgtt ttagactttg caggcccatg 80160
tggtctctgt cttaactatt caactctgct attctcgtaa aagcagccaa tatgtaatga 80220
atgggtgtag ctatattcta atacaactca atttacaaaa actggcagct gacctgccgg 80280
ttgactagcc ctgctctaca gccaaaagca ttgccactat caccaagcag atttcatctt 80340
cttacaggaa ggggtacaca gtgctgccag tcttgcttct gtctctgagt gttgctgctc 80400
tgtgttgtag aaaccctctt aattagaaag cagcagtcta ggatgtagat tcagagactg 80460
tacagtactg aggttctcat gtgagaaaga gattagcagt tagttttatc ttttattaag 80520
tcagtttctt actgtgacta tccttttttt ttaatcaggt acagatgaag tttttagttg 80580
agcaaatgag gcgaccagat ttcatggatg ctctacaggg ctttctgtct cctctaaacc 80640
ctgctcatca actaggaaac ctcaggtact ttcttggggg tttcattgat atatttaaat 80700
aaataccttt tctggataaa atcttgagaa aagtaaaaat gtctgttata attagaatgt 80760
tcaataattt atgcttctct ctctcattct cctaccctca aaataagagt agtatatctt 80820
aagttcagta ctgcctttat tcagaatgag tttttactac ttaaataata cagtttaaaa 80880
ccttctatgg ccagaatttc tgttaccata ggataagaaa tggaaatgta atatctgtaa 80940
aactaatgat atatctctat atatttgttg gaaattcata tgcaattata taacttttaa 81000
aacttttagt tttttttata ctctttagga atggattcct aaataaaaat tgaggtgaaa 81060
gttgtaaatc tttgtaacac ttcaaaaagc tatattgtat ttatatttta aaataaattt 81120
cagggtaaaa taataataaa gcaaaggtac ctagtaaagt ttttaactat tttaaaggct 81180
tgaagagtgt cgaattatgt cctctgcaaa aaggccactg tggttgaatt gggagaaccc 81240
agacatcatg tcagagttac tgtttcagaa caatgagatc atctttaaaa atggggatgg 81300
taaggaagag tattaatgag cttatgatgc atgaatttag ctatcttttt atacacagga 81360
tatttatgaa ccatgaaaac tactgaaagc catttaagga atatacacat gtgataaaat 81420
atgtaatatt tatcagatgt cttgaccttt gaaatatgca tgtataatca atgaaaagaa 81480
aagaagtact aggtttagat cagaagtcct gaaatcagtt ttttgttttt tctttttcct 81540
gttccctgcc tccaaccccc ctcccgtgga cctgtgtaga gaagtatttt ttgttgttgt 81600
tttggttttt tttttaatca gtttctaatt atcatttgct tagctgtgtg agtatccatt 81660
cattccataa atattctatg tgctaggccc tggggtttta gcagtgaaga aaacagaatc 81720
cctgccctct tggagcttac agcctaacag agaaaagagg gacattaaat gaataattac 81780
aaaaataaaa ttgcaagcat gttgcaaagg aagagtgtag tctgctcagg aaccatataa 81840
aagaaggtac ttatatggag gaaaaggcta tggggggagt gaaggaggat catggatggg 81900
ttttcaatag gaaatgacat ttcagcagtg aattctgttg atcccaatat tttaatataa 81960
acatgtgttc aaatttaagg attcagaaaa ataattacta taaatgcttt aattaaaaat 82020
ttttgtgaga tgcatgctca cttatcctac attgttattc aaatatgttt atgcaaagac 82080
tttaaaagtg gatttaagaa tcagaatatt aagagccatt tgtagtggtg catgcttgtg 82140
atcccagttg ctctggagga ttacttgagc ccaggagttt tagaccagcc tgggcaactt 82200
agcaagaccc catctcaaaa aattataaat acattaataa agctatgtaa aggctttgag 82260
tggacatata cactcattta taaatttttt gaaaagaaat cagaatattg ctttcctgaa 82320
gtttcttttg aagagtaaat atagctgtat ttgtttttca tttgaaaacc atgtgatggc 82380
gtgatcccca aatttgcatc tgtggcatta aatggtgata catattattt gaatttcaga 82440
tttacggcaa gatatgctaa cacttcaaat tattcgtatt atggaaaata tctggcaaaa 82500
tcaaggtctt gatcttcggt aggtaaccag taaggcaacc tgtatgttga aagttatcct 82560
gaaaaagtga actattaata attatagaag catatagagg catatgtcta aaaagaaatg 82620
tatgcagtaa ttatcagtag ttgattacac tatagtactt tgacatatcc tcctcttact 82680
tagaatagct aaattatatt cagctaagta aaaagagcta ataagctaat aaacactctg 82740
ctactgcctc tggagtgtca ccattaggaa caagacaaag gagacacaaa agacccctgt 82800
tttcattcag aaattaagag tttaaaagaa agtttcataa tgggaatttt ctaattctaa 82860
aactgtataa atcctcaaat attggaatca gttttgcagc aaaattatgc aaccagctat 82920
cttagagttt ttaccagtct gttggtttct acccaacttt ccacaatatc agtattatca 82980
ccaagttttc tgtcatgctt catcttctcc tagtcattgt tgcttctaaa atgttcttcc 83040
ttacctgact tgtctttttg caaatccata gtcattcagg caaagcccac tctgtccaaa 83100
gtattttggc ctataagtgg acatagagtc aagtctagct gtaacaacag ggtacattta 83160
gtaggaattg caggtaacac cagacaaggg cttatttgta tgcctcttat aaattttaag 83220
agtagctagt atacaaaaat gtgtcagtga caaatagttg taccctttta ttgcaaagaa 83280
gaaagtggac atttcaggtg acctgctaag gcacaaaatt gtcatcaact tcaaatttgt 83340
aactcctgat acgtagctta acccctgctg ctttccaaaa atggttaatg ttatatgaat 83400
caaatttcat tttttggtat aatttcctgt gtcatgagag atccacatgc cactactacc 83460
atgtccccca aaggaataga ctgtaaaaaa gattatagag ctaagaaaga gtaaaggaga 83520
taaccgtgta acgctggtta attacattgt ttaattataa agtaatgact ttgcaaaaaa 83580
gcatctgaag ttaagatgat tagaaatatt aatggttttt tagtcttgta ttttctgaat 83640
attttttaac ttaagtaaat ataagtaaaa attttatttc aagtttaact ttagattaaa 83700
attatttaag taaaatcata acagcatttt tatttatact tggcaaaact ataattcaga 83760
atcgggttta ttttaaccct gcttcttttt tttaataaca agacttagaa gacaattaaa 83820
ttctgtaaac tgtgagcatg ttcaacagtg ataaaaacat aaaataagaa agaatgagca 83880
ggagtacaac cttaagatat ttccctattt acgagggcag gtagaagaaa aggttgtgta 83940
agagaagtca tcaaaggaag ttggagtact agaggaagtg attgacaatt tgtagggcca 84000
gggcttcaag ggggttaaaa gaataaggcc tgtgaaaaag cacttggatt tagtgactca 84060
tcattagttt taagagttta ctcactagag tggtaggtgt agaagctagg ctacaaggaa 84120
ttaagtaaga aaatgaaaat aagtattgac cgtattagga atttaagaaa taaaggaaag 84180
gtggaaaata tggagagtag cttacgagaa gaacagagca aggaaaacca aactttggat 84240
acttacgtgt caatctgaat gttaggtgct ttttttcatt gtctctttaa atcctcacat 84300
ctgcaccctt gactaagtgt cctatttaat tttctatgtg aataaatgag aggtacccta 84360
aaaagcattt gtgccacatc ccaagtatta tggttgtatc aaagggaaac atttgtggga 84420
ttatttgagt tgtgagctga actagctgct gtttttatgg aacacgattt ttacttaaat 84480
aactagtagg caagctatgg ttattcagac atggatattt ggcagacatt ttcttgaaaa 84540
tgaacaatat gtgcctgtct ctttgaagaa aacaactgtg acagtatttg ttgccaatga 84600
taaaattcaa acttgcaaca aaaatttcat tagaaattca aaattagaat tttgaaaatt 84660
ctaattttca ttatctgccg ctgaacctaa tagagtccct aaacttaaca tctttctgat 84720
gagattcttg gtaatattaa caattgtggt tttttagtat ggtataatga aaagtatcaa 84780
catttggaac atctacaaat gaccatgcag gatactataa aatcatgtat gggtaagaga 84840
tccattaaaa ggcaagaaag acaaattgat tttaatgtaa ctgagtatga aaagtttatt 84900
gatacagttt tagattacat tttgcaactt aagaaactta tcttgtcagg ttttagaata 84960
gtaccaaaga aaaatatcac aattatctga aaagtctatt ataatactcc ttctttttct 85020
acctacctat ctttgtgagg ccagattttc tttttatact ttaattaaaa cattgcatta 85080
gattgcatac aaaagcatat atgagaatcc agctgggtac tatgaagcca gacatttaaa 85140
aattttttta aatgtgaaag aatttcactc ttctcactaa attttttaaa tgcatttttt 85200
gtttcatgaa atatgttact tatattaaca tgtcatagtt tgttgctttt aaatgaatta 85260
gtaaatattt aaaattttta ttttccctat ttcaatttct aatatcatta gatgtaattc 85320
acataactaa aagctctttg gagtcctcag taatttctac aagtgtaaag gagtcctgag 85380
accaaaattg agaacttctg ccctacagtt ttatttcgat gtcaattaaa catctttaaa 85440
ttaacacata tttttaaaat cataaatgtt tgtaaaattt taattgccac aataattttc 85500
ttaattcttt tctgataaaa atacagtgct ttctcagttg aaggttataa taaatgatga 85560
caggtaattt tgaggattat tccaggagta tgtttatcac accataaaaa agaaaattaa 85620
aattggggaa aggcagtaaa ggtcatgcat gacaaattta ctaataaaat actcatgttt 85680
tagcctgtta aaacatttgc tattttaaaa ttccatcatt taattgtaaa cgtgttactc 85740
ctctttcaga atgttacctt atggttgtct gtcaatcggt gactgtgtgg gacttattga 85800
ggtggtgcga aattctcaca ctattatgca aattcagtgc aaaggcggct tgaaaggtgc 85860
actgcagttc aacagccaca cactacatca gtggctcaaa gacaagaaca aaggagaaat 85920
gtgagttgta ttattctttc ttcctatgtt aatctaagtt tttgttagat gagtctgtcg 85980
gtgtttgtgt attcctctga gttagaacag agaaaacaat tgtactttct atggaaaaaa 86040
atatgctcaa cctttgaaat atttgatgtt aatggattta aatgattata attactttta 86100
atttggtaaa atcttaaaca ttcatcttat gtattatcta aaatgtattg ttattgctta 86160
ttctttttaa aacaaatgaa tattgcacat tcaaaatttt atttctaatt cattgttaaa 86220
atgattagaa aaaaataatt ttaatgacat gctaagtatt ttttcacatg aagaattatg 86280
ctttggtcag ggaacatctg gaaatttcct tagaaaccca tgaaaacttc acaatctcaa 86340
aatctttgga cataatttcc ttattcgttg tcagtgattg ttttcattgt ttaaatggaa 86400
acttgcaccc tgttttcttt tctcaagttg gcctgaatca ctatatttcc atactactca 86460
tgaggtgttt attctttgta gatatgatgc agccattgac ctgtttacac gttcatgtgc 86520
tggatactgt gtagctacct tcattttggg aattggagat cgtcacaata gtaacatcat 86580
ggtgaaagac gatggacaag taatggtttt ctctgtttaa aatgttttgg tgttcttaat 86640
ttattcaaga cattttgtat ctgcatatat caaactataa cataatttct tatttttgaa 86700
agctgtttca tatagatttt ggacactttt tggatcacaa gaagaaaaaa tttggttata 86760
aacgagaacg tgtgccattt gttttgacac aggatttctt aatagtgatt agtaaaggag 86820
cccaagaatg cacaaagaca agagaatttg agaggtgagc tcgagcaatt aaaaacacaa 86880
aataaagagt tctggctgct ctattagaaa caatcaatat ttttcaagca atttcaaaat 86940
aataaatgtt ggctgggtgt ggtggttcat gcctgtaatc ccaactcttt gggaggccga 87000
ggctggagga tcacttgagc tcaggaattg aaaccagcct gggtaacata gagagaattc 87060
atgtctacaa aaaaatttaa aaagtagcca ggcgtggtgg catgcactgt agtcccagct 87120
actcaggagg ctgagatggg aggatcactt gagcccagga ggttgaggtt gcagtgagcc 87180
attatcacgc cactgtactc caacctgggc aacagagtga gaccctgtat caaaataaat 87240
aaaatgaaat aatagaagtt cttttaccac ttcagcaaaa actatttttt gtttgttttt 87300
tattctatct tatttcaata gcttttgggg tacacgtggt ttttgattac atggatgaat 87360
taaatagtgg taaagtctga gattttagcg cacctgtaac ccaagtagtg tgctttgccc 87420
ccagtatata cttttttatc cctcactgtt cttcccaccg tctcccatct gagtctctgt 87480
agtccattat atcactctgt atgcctttgt gtacctatag cttagctccc acttacaagt 87540
gagaacatac tgtattttca ggttttccat tcctggcctc cagctccatc ccagttgctg 87600
caaaagacat tatttcattc ttttctgtgg tggagtagta ttctgtggtg tatatgtaca 87660
ctttctttat ccactcattg gtcagtgggt acttaacgtt ggtttcatat ctttgcaatt 87720
gtgaattgtg ctgcagtaaa catacgatat gcatgcagat gcctttttga tataatgact 87780
tcttttcctc tgggtagagg gattcctgga ccaaatggta gatctacttt tagttcttta 87840
agaaatctcc atactgtttt ccatagaggc tgtactaatt tacattccca ccaggagtgt 87900
ataagcattc tcatttcacc acatccatgt caacatctgt tgttttttga ctttttaatt 87960
atggccattc ttgcaggagt aaggtggtat ctcattgtgg ttttaatttg catttccctg 88020
atgattaatg atgttgagca ttttttcatg tttgttgacc atttatatat cttcttttga 88080
gaattgtcta ttcatgtcct tagcccactt tttttttttt tttttttttt ttttttgaga 88140
tggagtctca ctcttgttgc ccaggctgga gtacaatggc atgatctcag ctcaccgcaa 88200
cctccacctc ctgggttcaa agcaattctc ctgcctcagc ctcccaagta gctgggacta 88260
caggcacatg ccaccacaca cggctaattt ttgaattttt agtagagacg gggtttcacc 88320
atgttggtca ggctggtctt gaattcctga cctcaggtga tccacccgcc tcagcctccc 88380
taagtgctgg gattacaggc ttgagccact gcatcctgct ttaacccact ttttgatggg 88440
attctttgtt tcttgctgat ttgagttcct tatagattct ggatattagt cctttgtcag 88500
atgcatagtt tgggaatatt ttctcccatt ctacgggttg tctgttaact ttgatgattc 88560
tttcttttgt tatgcagagg ctttttagtt taattaggtc ccatttattt tgtttgtttt 88620
tgtcgcattt gcttttgggg tcttagtcat ttattatttg cctaggccag tgtttaaaag 88680
agtttttcct aagttatctt ctagaatttt tatggtttca ggtcttagat ttaagtcttc 88740
gatccatctt gagttgattt ttgtataagg tgagagacag ggatccagtt tcattctttt 88800
acatgtggct agctagtttt cccaccacca tttattaaac agaatgtcct ttctccaatt 88860
tatgttttta tatgtctaag atcagttcgt tgtaagtttt tggctttatt tctaggttct 88920
ccattctgtt ccattggtct gtgtgtctgc ttttgtgtgt atctgctgtt ttggtaatta 88980
tagtttcctg gtataatttg aagtccagta atgtgatgcc tccagatttg ttctttttgc 89040
ttagtcttgc tttggctatt cagactcttt ttggtcggtt ttatatgaat tttaggattt 89100
ttttttctaa ttctgtgaaa aatgatggtg acagtgtttt gtagttttcc ttgaaaagat 89160
ctttcacccc cttggttaag tacattccta ggtatttttt tgaagctaaa agggcttgtg 89220
ttcttaattt gattctcagc ttggttgttg ttggtgtata gcaatgctgc tgatttgtgt 89280
acactgattt tgtaacctga gactttactg aattcattta tcaaatctag gagtcttttt 89340
ttttatcttt tttaagacag agtcttgctc tgtcccccag gctagagcgt agtggtgcga 89400
tctcagctca ctgcaacctc cacctcctgg gtttaagcaa ttctcctgcc tcagctttcc 89460
aagtagctgg gattacaggc atgcaccacc atgctcagct aatttttata ttttttagta 89520
gagatggggt ttcactttgt tggccaggct ggtcttgaac tcccaatctc gggtgatcct 89580
cctgcctcgg cttcccaaag tgctgggatt atagaaatga gccaccacac ctggctgaaa 89640
tctaggaatt ttttggagaa ctcttgggtt ttctaggtat atgattatgt cattggtaaa 89700
cagctatagt ttgacttcct cttttccaat ttggatgcca atgtgggctt ccttgtcttg 89760
ttctagttct cagggggagt gctttcagct tttccccatt cagtatgata ttggccgtgg 89820
gtttgtcaca tgacttttat tattttgagg taagtccctt ctatgcctag tttgttgagt 89880
gaaaaactat tttaattttt tttttttgta tttatttgtg tgatgctgtg aaggaaaatg 89940
gaaagggaat acaatttaat ttgttgagct aattaaggcc taaaaagaaa gtaatcctta 90000
aacttcataa cacattaaag gtttttattt actgagcttt aaatagttgg actccacctc 90060
tatattgaca aataatgtat agtgcttaat acgacatttt ttggtcatac actttgagga 90120
aagtcagtca accataatca ccttgtttat tcataacttt tttaccacct tatggtatct 90180
cattagacta tatcagactt taaagtactt tttacaatct tctataaaat tctgctttgt 90240
ctacaacaca gtcctgactc tagcttaagc acaaaaggat ttagtatgaa ccaattcata 90300
catttaatac ttattaaact cctgacatgc caggcattgt tgtaggtgct ggtaataaag 90360
cagtttttaa aaagtcctta ttctcttgaa gtttacattc tagtggggta aagggaatca 90420
aaagatgttg gtaagagaag tgagagagga atgctatttt tttatagctt tgtctacgaa 90480
agcctctcta attttgtgac atttgagcaa agacctgaag gtattaacat catttgctcc 90540
aaactgacca aactgttctt attacttata ggtttcagga gatgtgttac aaggcttatc 90600
tagctattcg acagcatgcc aatctcttca taaatctttt ctcaatgatg cttggctctg 90660
gaatgccaga actacaatct tttgatgaca ttgcatacat tcgaaagacc ctagccttag 90720
ataaaactga gcaagaggct ttggagtatt tcatgaaaca aatgaatgat gcacatcatg 90780
gtggctggac aacaaaaatg gattggatct tccacacaat taaacagcat gcattgaact 90840
gaaaagataa ctgagaaaat gaaagctcac tctggattcc acactgcact gttaataact 90900
ctcagcaggc aaagaccgat tgcataggaa ttgcacaatc catgaacagc attagaattt 90960
acagcaagaa cagaaataaa atactatata atttaaataa tgtaaacgca aacagggttt 91020
gatagcactt aaactagttc atttcaaaat taagctttag aataatgcgc aatttcatgt 91080
tatgccttaa gtccaaaaag gtaaactttg aagattgttt gtatcttttt ttaaaaaaca 91140
aaacaaaaca aaaatcccca aaatatatag aaatgatgga gaaggaaaaa gtgatggttt 91200
tttttgtctt gcaaatgttc tatgttttga aatgtggaca caacaaaggc tgttattgca 91260
ttaggtgtaa gtaaactgga gtttatgtta aattacattg attggaaaag aatgaaaatt 91320
tcttattttt ccattgctgt tcaatttata gtttgaagtg ggtttttgac tgcttgttta 91380
atgaagaaaa atgcttgggg tggaagggac tcttgagatt tcaccagaga ctttttcttt 91440
ttaataaatc aaaccttttg atgatttgag gttttatctg cagttttgga agcagtcaca 91500
aatgagacct gttataaggt ggtatttttt tttttcttct ggacagtatt taaaggatct 91560
tattcttatt tcccagggaa attctgggct cccacaaagt aaaaaaaaaa aaaaatcata 91620
gaaaaagaat gagcaggaat agttcttatt ccagaattgt acagtattca ccttaagttg 91680
attttttttc tccttctgca attgaactga atacattttt catgcatgtt ttccagaaaa 91740
tagaagtatt aatgttatta aaaagattat tttttttatt aaaggctatt tatattatag 91800
aaactatcat taatatatat tctttattta catgatctgt cccatagtca tgcattgttt 91860
tgcaccccaa attttttatt gttcatagca gcatggtcag ctttcttctt gatctataga 91920
tgaggctcag gcactatccc atttatacca ataaccagtg tataactact taaggaaaac 91980
ataaaaactt catcttcttt ccttttattt cttatgtgaa tctcccgtct tccattctct 92040
tttataattg agaatgtctc aatcatatga aattagttac cagaattaac acaatttaga 92100
ctatcttcct gattccttaa acccctttac tgaagtatac tcatgaataa tactttaaaa 92160
tatgggggaa tagaaaccat gaacttttta cctttttaaa ctatttatcc atatctccaa 92220
agtagaacat taaaccattt taagatatgt ctcattccca agtagtcaga gctcactctc 92280
caactttatt aaatactatt tgagcacagg acacattctt aaacattttg aaaaacatta 92340
acccaagatg tagaggctac tgctagtcgt cattctagaa tctgatattt tactctgtat 92400
ttgaaatgaa tgattaatgt cctaggaaat tagctttagc agatgtccag gtgccacatc 92460
aaaaaagtgc aataattatt gacagttttt tagattaggc atattattgg aaaacaactt 92520
tataaagagt gaacattgta tactctagta aaacagcatc actttaaaaa tattcattta 92580
tgaaatctgt tacctatagt tgaagtcttg agtagtgaac aagggactct aataccaata 92640
ctcttaatat ctggctattt tagatccctt aaagggcata attattggaa atttaggtat 92700
ttcactaaag catgtatata atattgccaa caagaaaagt aaatttgaag attaagggaa 92760
cttacttctg caaactgtct tgcgatagtt aagcagaatt taaactctgt tttaagcagg 92820
aaaccagaaa gattattttg cagttgtaga agatttcata acttattaaa acttattaac 92880
attttgtgtt gtttagatat aggcagttga tacatactaa catcccagcc ttttcaatat 92940
cagggttaaa ttataggaaa actcagtaaa atggtacaaa tctgaaagtt tgatggtaga 93000
aactgaagat ttaacagaga actgtgtttt acccgagtgc caaaaatgct gtgagcctcc 93060
ttgcacaaaa tttataccac ttttgcattt ttatctatca gtccagatag ttgtctcccc 93120
tccttctccc aggacctctc caccattaaa atgcacaaac cacatggccg atttcaccat 93180
ttacatttat tttcaaaagt tactacaacc aaattaattc tattagaaga aatgtagaca 93240
aattctataa agactataga ttgtgaccta agaaagaaat gaggcaaaga accaaacatt 93300
gaattaaatg ctacatgggt gactaagatc tgtttcaagt cagtgataat atagccactt 93360
ctgggtactt cagtatcaga gatcagttct cgtggtttag acagttccta tctatagctg 93420
actatccttg tccttgaata tggtgtaact gactattggc tctacagttt tattgggcca 93480
cttaagaaat atttccttga ataattattt tgagaaaaag tctaaaagta ataaaaataa 93540
ttttaaacac actgtagtaa gaaatgactg ttggaaaatt atgctttcac tttctaccat 93600
attctcagct atacaaaacc atttattttg aagattttta gactactgtt aatttgaaat 93660
ctgttactct tattgtggaa tttgtttttt taaaaaagat gtttctaatt ggatttttaa 93720
aagaagaatg gaatttggtt gctattttac aatagaacct aagctttttg tggttcttag 93780
tgtcctatgt aaaacttagt gtcaaagtaa tcaactttga gattttccct tctattctgc 93840
tttatattaa aagcccatta gaaaatggga acctggtgaa tatataatga attgtaaaat 93900
attttaatgt gtaacttttt caactgtgaa actgacttga ttttttgatg aaaacagctg 93960
ctgataaagt attttgtgta aagtgtagtt cttattaatc aggaaaatga tgacttgatt 94020
agactgtata tgccctcttg gattttattt taaatggatt ggtgactttc acataggtaa 94080
aacacagtcc atctgtattc ttttttccat caaaaatcga gtgatttgga attataaaaa 94140
aattgtgagc agcctatttg aaaggcatca tggaaatttc acagcacaat aacacggatt 94200
tgttttttct taatgatgta aatccgttta attcatactt tgatcaatag cccatgcttg 94260
ccaactctga agaaatttaa tttccagcag tattttaaag ctagcctgtt aactttttct 94320
gaatatttaa agttcctctt ttttctatgt ctgcacaaac tgcagacctg ggctggaccc 94380
acatactcaa gagtccacct taagaaatta ttttgatgtc caagacatca ctaaaatatt 94440
taagtttaaa gataatatgt ggtgttaata gattgtggtg cttttactat ttaaagacaa 94500
ctttcatact tcagatgttt ttgagaagag gggaatgtga ggggaggggg cagaacaggg 94560
aggagttgtt tgaatgaatt acattcttta tatccatcct gctcatttgg ggcatgtctt 94620
taagagaagg ctgaaagttg tgagagtata ttgtataccg taagagaatc aactcttcat 94680
catggatggg attgtgaagg ctgaactata aaattcagca ttgacagcat cctcaattaa 94740
taattcttgg tgacagaata atacagctgg gctgtttttt aaaatataaa caataccatt 94800
tttaattatt acattaaaaa ttgtaaatat atctatgtgc catggcctgg gaagcctgct 94860
ttcttttttc ataaaaatta tttttactgt atgaaaagat catggggttt agctcaaaat 94920
atctgtggtc ctgataaaat tggattggta actctacctc agaaggaaaa tgggaaaaaa 94980
aaatagatga gtcacaattc aatacttcaa gctcagaaac tgtgcagatc actgaatttt 95040
agatttataa agtcagagtt ggcatgcctt gtttttaatg atatggaaga ccttaagaaa 95100
aaaacttggc tgaagtttaa tcgttggtcc agccatttga aaaaggcaat agtttgagga 95160
ggttcccgaa ttcggcattt gaaattcatt ttgttctctc ttcttcatta ttagtgcatt 95220
tggtgtgtgt atacttgcac acaattctgt ttgtgtacac actgcttgct tagccctagt 95280
caagaggcat cttttataaa aggtgtaaag aaatatcaag gttctaaaat tcggaagagt 95340
ttagaattta ttaggagttt cccaagttgg gatgttagtc tttaaataaa cttcatgcac 95400
ctattccact taaggttttg cacctccttt ttattagtgc agtgccattt cttctgcttg 95460
attttaggta tgttaatatt ccagccttgc tagttagcat aaagtgacag gtgtgagcca 95520
tgaggaaatt ttctgactta atttgtacac aactacatat aagagtttta gtggaggaaa 95580
aaaattagtc ccttgtgcgt atacagtagt taggtaaatg atttttctac caacagtata 95640
ctccattcct catgtaggta agtacagaaa aggtttttaa atgtattttt ttagccagtt 95700
aaagtctatg aatctatctg caaccttatt taatctgtca ctataataat tttgtggtta 95760
tgctaagaac catgtatact tttaggtatt cttatttttg tcaatttttc taggttggca 95820
aggaggcaga aaaccttcat tgtttcatat taaaatataa ttagactaaa cttaattcta 95880
gtatgaattt ccaaaatcat tatctattta tttcattttt atttaatttt gtttttattt 95940
catttttaaa agtcccttgt tcaatttaac ttatgttcct aagagaggtt ggagaacttg 96000
gccttcatct gatttcaaaa atgttttgag tttcaaatga agttaatggt ttcagtgtga 96060
ttcagtcctc agacctaatt gggttgaata aaatctaaaa gaatataccc ttttggagca 96120
taacatttta ataccttggg gaatgtggca ctaccaaaag aagactacta acacgtcaga 96180
tgttcacctg gaagctttat caagaaattc gaaccaccct tttggcccca ttaattgtag 96240
caagtttatt tctctatatt ttgtcattca gtgaattgaa gtcctgtggt atactgcatt 96300
cattagaaga aaaacgtttt taatgtcctt ttaatgatgg cccagaaagc atttgacaca 96360
gcaagatgca tgtgttacta tattgagaat atagaataat aacagtatca ctaaatttaa 96420
gacctcttcc cagtcttgct gttcctagca agaagtttgg cctgtgactg cacttactgt 96480
ttatgctcat cagaaactgt caatgtctgc ttttctttaa ctctgcagtc tgtaacatca 96540
cgctgtttat taaaaaaaaa aagaaaaatt actttttgtg tccaaacaat ccttagtgta 96600
ctacataagc aaaaaactgt gataattctc ttttgccatt ccttttgaaa agcaagccgg 96660
tgttgctaat aatcaaaatt tagctgaatt tgagttcttt tcagtaatga ctaagaatac 96720
ttgattgaaa atctgaaact attatacctt aaaagccaat ttttctaccc cagtaaagtg 96780
atgaatatta aaggaatgta tgtttaaata tttacttcct ttaagcataa agaattatat 96840
gcttgtattt taagaaatat atgtatatac atatatgtat gaatgtatgt atgtatatgc 96900
aataggtaag tagacttttt tccaagtcgt ttgaagatca gaacctagaa atgaagttag 96960
gctagaagca aactggtttt gctttcagtt ctcataaaca ttgcaaaagg taagtgtggg 97020
cttttctttg accattaatg cacataggca ttaacaactt agtatttctg agcaattaag 97080
caaataatta cttaaatttt atttatttgc caaatggttt aaataatttt gaattgactt 97140
tgttctccag ggataatctc tctctttgct ggaatgaatc aggtagctcc tatctaaatg 97200
gaaaactgtg gtaattgaaa cacacgcttt atattttaaa ttagcagttt tgaatttgtt 97260
agggaaaaaa aaaatcccag caactgcata ttgttaggta gaagtcaaat ttacaaaaac 97320
ggaatagaga tgtgcccttg agaaaagtgt agaatctcaa tgtgcagatg atttaaaatg 97380
tgcgtgcaca tcaaatgttc atgtgtactt acatacttta ttacagagaa gtctttggta 97440
tacaaaatag tttaccacaa ccttttaaac agcaggttct gggccttaaa tgcgtatcac 97500
atttagccaa gagaactcag gtaggggcat ggaaaatgaa ctgcagctcc ctatccctag 97560
cctctatacc agctgtccag tgaaaagtac caaggctcac tgaatgttat aacctagcag 97620
atttttaaat aaatgatcta acatttttga gcactgctac tagatgctag aagctaagct 97680
aaagtttcac ctgccctact ttgcttattc cataaaataa caactgcgtg aaagaacggg 97740
ttatccccat tttatagatg agaaaagaaa ggtttacaca ggttagctta tttgcccaaa 97800
gttgtaatta tggcctacaa agtcaaataa atcctactct gagacacatg ttctttccac 97860
cattgcacac tagaaaggaa aacaccaaga ttattcatta ctcatcaagt caatattgct 97920
gtattcagct aatttagtaa tatgtgtcga aattaattgc taaaagggat taaactgact 97980
tagaatcagt tttttgtttg attacatcta catacaaaag tagcttcaaa tgtctcattc 98040
cactgtccat aatttaagat ttttgagtat aataaaattt taaagatact ttgaggcact 98100
ttggaaaatc agaccaaaat ctcttttcca ctcatagatt cggcttaatc aacctggaaa 98160
gcatttgttg agagccttat gacatcattt aataaccatg gttgattcat taattaaagt 98220
acagacaatt gttgactatc catgtgggac ttcttttcta ttaggttgat gcaaaaataa 98280
ttgcggtttt tcgccattaa aagttaacag caaaaactgg aattactttt gcaccagcct 98340
aatacgatgt ggatcatctg agatgaatgt taaaatccag tatagcttct tcatatttct 98400
ggcccatttt tcccaccaga aagtgcacaa agtgaaatga gcttatgaaa agcttaatta 98460
actagaaaaa tgttactgaa agaaaaatta catggtacat gacaaggcta aatactagta 98520
actctaaact tagtgaattt tctaggcagc agctttcctc tgctgtctag a 98571
<210> 6
<211> 3066
<212> DNA
<213> 智人
<400> 6
atggataaag tgtgctcagg tgagggttgg ctggtgggcc gctgcagggc gggggcctgt 60
ccagtgctcc cccacttact tgctgcctcc cgactgctgt aattatgggt ctgtaaccac 120
cctggactgg gtgctcctca ctgacggact tgtctgaacc tctctttgtc tccagcgccc 180
agcactgggc ctggcaaaac ctgagacgcc cggtacatgt tggccaaatg aatgaaccag 240
attcagaccg gcaggggcgc tgtggtttag gaggggcctg gggtttctcc caggaggttt 300
ttgggcttgc gctggagggc tctggactcc cgtttgcgcc agtggcctgc atcctggtcc 360
tgtcttcctc atgtttgaat ttctttgctt tcctagtctg gggagcaggg aggagccctg 420
tgccctgtcc caggatccat gggtaggaac accatggaca gggagagcaa acggggccat 480
ctgtcaccag gggcttaggg aaggccgagc cagcctgggt caaagaagtc aaaggggctg 540
cctggaggag gcagcctgtc agctggtgca tcagaggctg tggccaggcc agctgggctc 600
ggggagcgcc agcctgagag gagcgcgtga gcgtcgcggg agcctcgggc accatgagcg 660
acgtggctat tgtgaaggag ggttggctgc acaaacgagg ggagtacatc aagacctggc 720
ggccacgcta cttcctcctc aagaatgatg gcaccttcat tggctacaag gagcggccgc 780
aggatgtgga ccaacgtgag gctcccctca acaacttctc tgtggcgcag tgccagctga 840
tgaagacgga gcggccccgg cccaacacct tcatcatccg ctgcctgcag tggaccactg 900
tcatcgaacg caccttccat gtggagactc ctgaggagcg ggaggagtgg acaaccgcca 960
tccagactgt ggctgacggc ctcaagaagc aggaggagga ggagatggac ttccggtcgg 1020
gctcacccag tgacaactca ggggctgaag agatggaggt gtccctggcc aagcccaagc 1080
accgcgtgac catgaacgag tttgagtacc tgaagctgct gggcaagggc actttcggca 1140
aggtgatcct ggtgaaggag aaggccacag gccgctacta cgccatgaag atcctcaaga 1200
aggaagtcat cgtggccaag gacgaggtgg cccacacact caccgagaac cgcgtcctgc 1260
agaactccag gcaccccttc ctcacagccc tgaagtactc tttccagacc cacgaccgcc 1320
tctgctttgt catggagtac gccaacgggg gcgagctgtt cttccacctg tcccgggagc 1380
gtgtgttctc cgaggaccgg gcccgcttct atggcgctga gattgtgtca gccctggact 1440
acctgcactc ggagaagaac gtggtgtacc gggacctcaa gctggagaac ctcatgctgg 1500
acaaggacgg gcacattaag atcacagact tcgggctgtg caaggagggg atcaaggacg 1560
gtgccaccat gaagaccttt tgcggcacac ctgagtacct ggcccccgag gtgctggagg 1620
acaatgacta cggccgtgca gtggactggt gggggctggg cgtggtcatg tacgagatga 1680
tgtgcggtcg cctgcccttc tacaaccagg accatgagaa gctttttgag ctcatcctca 1740
tggaggagat ccgcttcccg cgcacgcttg gtcccgaggc caagtccttg ctttcagggc 1800
tgctcaagaa ggaccccaag cagaggcttg gcgggggctc cgaggacgcc aaggagatca 1860
tgcagcatcg cttctttgcc ggtatcgtgt ggcagcacgt gtacgagaag aagctcagcc 1920
cacccttcaa gccccaggtc acgtcggaga ctgacaccag gtattttgat gaggagttca 1980
cggcccagat gatcaccatc acaccacctg accaagatga cagcatggag tgtgtggaca 2040
gcgagcgcag gccccacttc ccccagttct cctactcggc cagcggcacg gcctgaggcg 2100
gcggtggact gcgctggacg atagcttgga gggatggaga ggcggcctcg tgccatgatc 2160
tgtatttaat ggtttttatt tctcgggtgc atttgagaga agccacgctg tcctctcgag 2220
cccagatgga aagacgtttt tgtgctgtgg gcagcaccct cccccgcagc ggggtaggga 2280
agaaaactat cctgcgggtt ttaatttatt tcatccagtt tgttctccgg gtgtggcctc 2340
agccctcaga acaatccgat tcacgtaggg aaatgttaag gacttctgca gctatgcgca 2400
atgtggcatt ggggggccgg gcaggtcctg cccatgtgtc ccctcactct gtcagccagc 2460
cgccctgggc tgtctgtcac cagctatctg tcatctctct ggggccctgg gcctcagttc 2520
aacctggtgg caccagatgc aacctcacta tggtatgctg gccagcaccc tctcctgggg 2580
gtggcaggca cacagcagcc ccccagcact aaggccgtgt ctctgaggac gtcatcggag 2640
gctgggcccc tgggatggga ccagggatgg gggatgggcc agggtttacc cagtgggaca 2700
gaggagcaag gtttaaattt gttattgtgt attatgttgt tcaaatgcat tttgggggtt 2760
tttaatcttt gtgacaggaa agccctcccc cttccccttc tgtgtcacag ttcttggtga 2820
ctgtcccacc gggagcctcc ccctcagatg atctctccac ggtagcactt gaccttttcg 2880
acgcttaacc tttccgctgt cgccccaggc cctccctgac tccctgtggg ggtggccatc 2940
cctgggcccc tccacgcctc ctggccagac gctgccgctg ccgctgcacc acggcgtttt 3000
tttacaacat tcaactttag tatttttact attataatat aatatggaac cttccctcca 3060
aattct 3066
<210> 7
<211> 5300
<212> DNA
<213> 智人
<400> 7
tgggaggggg cggtaagcgg gggctggggg gagggggcgg ggggggccgc gccgtgctag 60
ccgttgggcc tgcctcggag gaggcgtcgc cgccgccgct gccgctgccg gcgccgttgc 120
cgctgccggg aaacacaagg aaagggaacc agcgcagcgt ggcgatgggc gggggtagag 180
ccccgccgga gaggctgggc ggctgccggt gacagactgt gccctgtcca cggtgcctcc 240
tgcatgtcct gctgccctga gctgtcccga gctaggtgac agcgtaccac gctgccacca 300
tgaatgaggt gtctgtcatc aaagaaggct ggctccacaa gcgtggtgaa tacatcaaga 360
cctggaggcc acggtacttc ctgctgaaga gcgacggctc cttcattggg tacaaggaga 420
ggcccgaggc ccctgatcag actctacccc ccttaaacaa cttctccgta gcagaatgcc 480
agctgatgaa gaccgagagg ccgcgaccca acacctttgt catacgctgc ctgcagtgga 540
ccacagtcat cgagaggacc ttccacgtgg attctccaga cgagagggag gagtggatgc 600
gggccatcca gatggtcgcc aacagcctca agcagcgggc cccaggcgag gaccccatgg 660
actacaagtg tggctccccc agtgactcct ccacgactga ggagatggaa gtggcggtca 720
gcaaggcacg ggctaaagtg accatgaatg acttcgacta tctcaaactc cttggcaagg 780
gaacctttgg caaagtcatc ctggtgcggg agaaggccac tggccgctac tacgccatga 840
agatcctgcg gaaggaagtc atcattgcca aggatgaagt cgctcacaca gtcaccgaga 900
gccgggtcct ccagaacacc aggcacccgt tcctcactgc gctgaagtat gccttccaga 960
cccacgaccg cctgtgcttt gtgatggagt atgccaacgg gggtgagctg ttcttccacc 1020
tgtcccggga gcgtgtcttc acagaggagc gggcccggtt ttatggtgca gagattgtct 1080
cggctcttga gtacttgcac tcgcgggacg tggtataccg cgacatcaag ctggaaaacc 1140
tcatgctgga caaagatggc cacatcaaga tcactgactt tggcctctgc aaagagggca 1200
tcagtgacgg ggccaccatg aaaaccttct gtgggacccc ggagtacctg gcgcctgagg 1260
tgctggagga caatgactat ggccgggccg tggactggtg ggggctgggt gtggtcatgt 1320
acgagatgat gtgcggccgc ctgcccttct acaaccagga ccacgagcgc ctcttcgagc 1380
tcatcctcat ggaagagatc cgcttcccgc gcacgctcag ccccgaggcc aagtccctgc 1440
ttgctgggct gcttaagaag gaccccaagc agaggcttgg tggggggccc agcgatgcca 1500
aggaggtcat ggagcacagg ttcttcctca gcatcaactg gcaggacgtg gtccagaaga 1560
agctcctgcc acccttcaaa cctcaggtca cgtccgaggt cgacacaagg tacttcgatg 1620
atgaatttac cgcccagtcc atcacaatca caccccctga ccgctatgac agcctgggct 1680
tactggagct ggaccagcgg acccacttcc cccagttctc ctactcggcc agcatccgcg 1740
agtgagcagt ctgcccacgc agaggacgca cgctcgctgc catcaccgct gggtggtttt 1800
ttccccctaa ctttttactt agcctttttg gtttgtgtcc ccacccccac ctcctcaccc 1860
cctttccagt tcttcttcag gcccctccca gacgcacccc agcggcccct gcagcccctg 1920
cctccagcct ccagcctcac ctttgtgccc agactcgcat ttggaagact ccacctcccg 1980
cccaggcctg ggctgttggg cggttggaga ttcaggtttt aatccacaca agccccagtg 2040
aggggtgaag catggcgcct ggggcctgcc tgagtttctg gcctgggtgt cgtgctggtg 2100
tctgcctccg cgctgctgca tctggacgaa ggctgccttc tggtgggacg cgacacccgg 2160
cagacagtgg tgctgccttc caggccccgt ggcctaggct cggagtggcc aggcacgggg 2220
cggtccaatc ccccacccgc tgtcccccta tgggggcaga aaagcaataa tgtccagggg 2280
caggcagggg cccttgggag ctgcagggct gggggttagg gctgctccct ggtgaatgga 2340
gtcagatcct aggatctgta ccatggggaa ccaggagtgg ccgggctggg tgccgcctcc 2400
tggtccggcc tcctccccac caaactgtcc tcaccctatg gatgaggcag gaggaacatt 2460
tggggccaaa cctgcctgcc tcccagcccc gtgccttact agggcttcct tccagctggc 2520
cttacctccc gctggaccct gggcctggcc tggccccact gggggctatg ggctgggctc 2580
accctctcct ctgcgggggt ggagggccac cagccttggc tgttacaatc ttacaccgga 2640
cagtattggg ccccatggac ttggtcaggg aggggtgggg gtgggcatct ctggtaccta 2700
ttggggtggg gggcctctga aaagggaggc tcctaggccc ccctcacccc tccctctccc 2760
cagggcccca cgttctgcag ccttaaggtt gaacatgagt gcacgtccat gtcagtgctg 2820
tgggactcct gtgcgtgcct cggactgcgt gtgtcggcgg gacgcaggca cacgtgggtg 2880
tgtgtgcatg tgtgtttgtg tgagggcagc gtgtcctcca gtgtgcatgg tgtgtgggct 2940
tgggccccat ccctggcccg agcatttcat cctgtggggg aggggtgctg acctagtggg 3000
aggagcccca ctgtgatcca tgagctgccc tgcccacgcc tcccctccct gtagcaacac 3060
ctctgggtgt ttggagttta gcttttgtgg gtttgctctc cctatcccat ctcctgtact 3120
acacagttca tggcagggtg gggaggggtg gggttggttc gggtgggtga gggtcttttt 3180
cctctgtgtg cgatgttgtt atctgacagt tctccgtccc tactggcctt tctcctcgtc 3240
ttcatatttg tacggtacaa gcaataaaga cactcatttc agaccagggc ccagcctgca 3300
ctcacgccag cccaaccact ctgggctttg ccttggtgat ggagtcagac ccctgggccc 3360
cagctcctcc tgtactagcc gttcccttca gcaaggaggg cactgagctc agggtgaggg 3420
cagctggggt gtgtgcagga gctcaggctg gagagggtgg gtggagctgg tgctgtgggg 3480
ctgaggggta tgggaaggct ccccgcatgt gggggtgggg tggacagaga ccactccagg 3540
ccctcagtgc tgcttaggct aagagaggtg gggtggaggg acagggctgg aagatctggg 3600
tagcccagaa tgaggagggt gcctgtgctg tcactgaatg agagggagtg gttcattcca 3660
cccggctgcc gagcctcaga ggggggcatt cctatcctgc cccacctccc tgtttatgct 3720
gccacctgga agccttgagg cccccaaatt ccagtacaga cccagtggtg tgttcatggt 3780
ggcgtggttg ctgtcacctg ggagctcctg agcgtttggt tagaaccctg ttcagcttgg 3840
ggtcagccct cccctagtca ctgcccttta gcctggatgt gtctgggccc ctgcacttcc 3900
cgtgcttgag tcacgtggct gcatggccgg gcgctggccg gatggaacac ctcccccagc 3960
aagggaccag ggaccagagc cctggcctgc cctgctgagc cctgctgtgc agagggcctg 4020
gcacagatga atttgagatt ttgccgcaag gtgttagcac ttcacaccca ttgagtcttt 4080
gagattttaa gtgaatgtaa gcagaaaaag tcagatccaa tttacagaaa tcagagttag 4140
ctacagctag gactcgtttg gttggggttt tttagtttgt ctttctaaag tcatgtggac 4200
cttaatttaa ttacaaaagt ctaccctggt ggtcataaaa taggcaggcc tatgaagaaa 4260
ggccttttac tcttccatct cgtcccagcc ccgagttgac ccacgttgct gctcctcaca 4320
ccatggtgat gcaggtctcg tagtgtgggc acaggcctgg ctacctcatc tttttagtgc 4380
ctctctcctc ttccacagga tggggtccca cagctgcagc agctggcccc gtagttgagc 4440
atgtgtggtt atcctgtaga gcttttccca agaagggtgt ttgaacttag agtcttaata 4500
aaatcttacc aaataaattt tgagtagaat aatcgtcttt tgcaatgtac attttaaaaa 4560
tttcacacat tcttttttgt atataaagaa cagtgactgg gcacagtggc tcatgcctgt 4620
aatcccagca atttgggagg ccgaggcggg cgggtctctt gaggccaggg gttcgagacc 4680
agcctgggca tcatagggag accttcatct ctacaaaaaa tacaaaaatt agctgggcat 4740
ggtggtgcat gcctgcaatc ccagctaact tggaaggctg aggtgaggtg ggaagatcac 4800
ttgagcccag gagtttgagg ctgcagtgag ctatgattgc ggcactgcac tgcagcctgg 4860
gacaatgaga ctgtgtctct aaaaataaaa aaaaaaaaaa catgatacat gctattaaaa 4920
aagacagcaa agcaggagta taagaaagga aattcacccg aggtcgcagg gccttgagta 4980
ctcattttgg tgctgattac ctctctgcaa atggacacgg catcataaat tggtagtttc 5040
ctgctctttt tgtgtaatct tttccagtta atgtgaagcc tctgggggct gccctcgtgc 5100
actgatggtt gtgtggagtc gggggcggca gtgcgattcc cttttagctg ctgcatgggg 5160
ggaactcagg ctttccagct gcttcctggg gttccatggg gtagacccct caaccgcttc 5220
agctgccccg ttaacaggaa ttgacttggt ttcgtttggt gctaccagca gtcctgtaat 5280
aaactagcta tccatctgta 5300
<210> 8
<211> 3826
<212> DNA
<213> 智人
<400> 8
gcgagaggcc gagcttgctg cattgcagcc gccgcggcgc cgctcggctc ttcactccca 60
acaatggcgg ctccgagccc gagcggcggc ggcggctccg ggggcggcag cggcagcggc 120
acccccggcc ccgtagggtc cccggcgcca ggccacccgg ccgtcagcag catgcagggt 180
aaacgcaaag cactgaagtt gaattttgca aatccacctt tcaaatctac agcaaggttt 240
actctgaatc ccaatcctac aggagttcaa aacccacaca tagagagact gagaacacac 300
agcattgagt catcaggaaa actgaagatc tcccctgaac aacactggga tttcactgca 360
gaggacttga aagaccttgg agaaattgga cgaggagctt atggttctgt caacaaaatg 420
gtccacaaac caagtgggca aataatggca gttaaaagaa ttcggtcaac agtggatgaa 480
aaagaacaaa aacaacttct tatggatttg gatgtagtaa tgcggagtag tgattgccca 540
tacattgttc agttttatgg tgcactcttc agagagggtg actgttggat ctgtatggaa 600
ctcatgtcta cctcgtttga taagttttac aaatatgtat atagtgtatt agatgatgtt 660
attccagaag aaattttagg caaaatcact ttagcaactg tgaaagcact aaaccactta 720
aaagaaaact tgaaaattat tcacagagat atcaaacctt ccaatattct tctggacaga 780
agtggaaata ttaagctctg tgacttcggc atcagtggac agcttgtgga ctctattgcc 840
aagacaagag atgctggctg taggccatac atggcacctg aaagaataga cccaagcgca 900
tcacgacaag gatatgatgt ccgctctgat gtctggagtt tggggatcac attgtatgag 960
ttggccacag gccgatttcc ttatccaaag tggaatagtg tatttgatca actaacacaa 1020
gtcgtgaaag gagatcctcc gcagctgagt aattctgagg aaagggaatt ctccccgagt 1080
ttcatcaact ttgtcaactt gtgccttacg aaggatgaat ccaaaaggcc aaagtataaa 1140
gagcttctga aacatccctt tattttgatg tatgaagaac gtgccgttga ggtcgcatgc 1200
tatgtttgta aaatcctgga tcaaatgcca gctactccca gctctcccat gtatgtcgat 1260
tgatatcgct gctacatcag actctagaaa aaagggctga gaggaagcaa gacgtaaaga 1320
attttcatcc cgtatcacag tgtttttatt gctcgcccag acaccatgtg caataagatt 1380
ggtgttcgtt tccatcatgt ctgtatactc ctgtcaccta gaacgtgcat ccttgtaata 1440
cctgattgat cacacagtgt tagtgctggt cagagagacc tcatcctgct cttttgtgat 1500
gaacatattc atgaaatgtg gaagtcagta cgatcaagtt gttgactgtg attagatcac 1560
atcttaaatt catttctaga ctcaaaacct ggagatgcag ctactggaat ggtgttttgt 1620
cagacttcca aatcctggaa ggacacagtg atgaatgtac tatgtctgaa catagaaact 1680
cgggcttgag tgagaagagc ttgcacagcc aacgagacac attgccttct ggagctggga 1740
gacaaaggag gaatttactt tcttcaccaa gtgcaataga ttactgatgt gatattctgt 1800
tgctttacag ttacagttga tgtttgggga tcgatgtgct cagccaaatt tcctgtttga 1860
aatatcatgt taaattagaa tgaatttatc tttaccaaaa accatgttgc gttcaaagag 1920
gtgaacatta aaatatagag acaggacaga atgtgttctt ttctccttta ccagtcctat 1980
ttttcaatgg gaagactcag gagtctgcca cttgtcaaag aaggtgctga tcctaagaat 2040
ttttcattct cagaattcgg tgtgctgcca acttgatgtt ccacctgcca caaaccacca 2100
ggactgaaag aagaaaacag tacagaaggc aaagtttaca gatgttttta attctagtat 2160
tttatctgga acaacttgta gcagctatat atttcccctt ggtcccaagc ctgatacttt 2220
agccatcata actcactaac agggagaagt agctagtagc aatgtgcctt gattgattag 2280
ataaagattt ctagtaggca gcaaaagacc aaatctcagt tgtttgcttc ttgccatcac 2340
tggtccaggt cttcagtttc cgaatctctt tcccttcccc tgtggtctat tgtcgctatg 2400
tgacttgcgc ttaatccaat attttgcctt ttttctatat caaaaaacct ttacagttag 2460
cagggatgtt ccttaccaag gatttttagc cccaaatctc tcatattcgc tagtgtttaa 2520
aaggctaaga atagtggggc ccagccgatg tggtaggtga taaagaggca tcttttctag 2580
agacacattg gaccagatga ggatccgaaa cggcagcctt tacgttcatc acctgctaga 2640
acctctcgta gtccatcacc atttcttggc attggaattc tactggaaaa aaatacaaaa 2700
agcaaaacaa aaccctcagc actgttacaa gaggccattt aagtatcttg tgcttcttca 2760
cttacccatt agccaggttc tcattaggtt ttgcttgggc ctccctggca ctgaacctta 2820
ggctttgtat gacagtgaag cagcactgtg agtggttcaa gcacactgga atataaaaca 2880
gtcatggcct gagatgcagg tgatgccatt acagaaccaa atcgtggcac gtattgctgt 2940
gtctcctctc agagtgacag tcataaatac tgtcaaacaa taaagggaga atggtgctgt 3000
ttaaagtcac atccctgtaa attgcagaat tcaaaagtga ttatctcttt gatctacttg 3060
cctcatttcc ctatcttctc ccccacggta tcctaaactt tagacttccc actgttctga 3120
aaggagacat tgctctatgt ctgccttcga ccacagcaag ccatcatcct ccattgctcc 3180
cggggactca agaggaatct gtttctctgc tgtcaacttc ccatctggct cagcataggg 3240
tcactttgcc attatgcaaa tggagataaa agcaattctg actgtccagg agctaatctg 3300
accgttctat tgtgtggatg accacataag aaggcaattt tagtgtatta atcatagatt 3360
attataaact ataaacttaa gggcaaggag tttattacaa tgtatcttta ttaaaacaaa 3420
agggtgtata gtgttcacaa actgtgaaaa tagtgtaaga actgtacatt gtgagctctg 3480
gttatttttc tcttgtacca tagaaaaatg tataaaaatt atcaaaaagc taatgtgcag 3540
ggatattgcc ttatttgtct gtaaaaaatg gagctcagta acataactgc ttcttggagc 3600
tttggaatat tttatcctgt attcttgttt gaattcctcc tctatttaag atatatacat 3660
ggaatcgaag tgtttatgta atagttctat ccttttgcct gcaggtcagt tgtaataaat 3720
ctaggatgtg atgatgactt tgtaatttga ttttctgaaa tcagaccctg agaggggaaa 3780
atcttaaagt aaattacatt aaattatctg tgcatttcac accagg 3826
<210> 9
<211> 7011
<212> DNA
<213> 智人
<400> 9
atggcggcgg cggcggggaa tcgcgcctcg tcgtcgggat tcccgggcgc cagggctacg 60
agccctgagg caggcggcgg cggaggagcc ctcaaggcga gcagcgcgcc cgcggctgcc 120
gcgggactgc tgcgggaggc gggcagcggg ggccgcgagc gggcggactg gcggcggcgg 180
cagctgcgca aagtgcggag tgtggagctg gaccagctgc ctgagcagcc gctcttcctt 240
gccgcctcac cgccggcctc ctcgacttcc ccgtcgccgg agcccgcgga cgcagcgggg 300
agtgggaccg gcttccagcc tgtggcggtg ccgccgcccc acggagccgc gagccgcggc 360
ggcgcccacc ttaccgagtc ggtggcggcg ccggacagcg gcgcctcgag tcccgcagcg 420
gccgagcccg gggagaagcg ggcgcccgcc gccgagccgt ctcctgcagc ggcccccgcc 480
ggtcgtgaga tggagaataa agaaactctc aaagggttgc acaagatgga tgatcgtcca 540
gaggaacgaa tgatcaggga gaaactgaag gcaacctgta tgccagcctg gaagcacgaa 600
tggttggaaa ggagaaatag gcgagggcct gtggtggtaa aaccaatccc agttaaagga 660
gatggatctg aaatgaatca cttagcagct gagtctccag gagaggtcca ggcaagtgcg 720
gcttcaccag cttccaaagg ccgacgcagt ccttctcctg gcaactcccc atcaggtcgc 780
acagtgaaat cagaatctcc aggagtaagg agaaaaagag tttccccagt gccttttcag 840
agtggcagaa tcacaccacc ccgaagagcc ccttcaccag atggcttctc accatatagc 900
cctgaggaaa caaaccgccg tgttaacaaa gtgatgcggg ccagactgta cttactgcag 960
cagatagggc ctaactcttt cctgattgga ggagacagcc cagacaataa ataccgggtg 1020
tttattgggc ctcagaactg cagctgtgca cgtggaacat tctgtattca tctgctattt 1080
gtgatgctcc gggtgtttca actagaacct tcagacccaa tgttatggag aaaaacttta 1140
aagaattttg aggttgagag tttgttccag aaatatcaca gtaggcgtag ctcaaggatc 1200
aaagctccat ctcgtaacac catccagaag tttgtttcac gcatgtcaaa ttctcataca 1260
ttgtcatcat ctagtacttc tacgtctagt tcagaaaaca gcataaagga tgaagaggaa 1320
cagatgtgtc ctatttgctt gttgggcatg cttgatgaag aaagtcttac agtgtgtgaa 1380
gacggctgca ggaacaagct gcaccaccac tgcatgtcaa tttgggcaga agagtgtaga 1440
agaaatagag aacctttaat atgtcccctt tgtagatcta agtggagatc tcatgatttc 1500
tacagccacg agttgtcaag tcctgtggat tccccttctt ccctcagagc tgcacagcag 1560
caaaccgtac agcagcagcc tttggctgga tcacgaagga atcaagagag caattttaac 1620
cttactcatt atggaactca gcaaatccct cctgcttaca aagatttagc tgagccatgg 1680
attcaggtgt ttggaatgga actcgttggc tgcttatttt ctagaaactg gaatgtgaga 1740
gagatggccc tcaggcgtct ttcccatgat gtcagtgggg ccctgctgtt ggcaaatggg 1800
gagagcactg gaaattctgg gggcagcagt ggaagcagcc cgagtggggg agccaccagt 1860
gggtcttccc agaccagtat ctcaggagat gtggtggagg catgctgcag cgttctgtca 1920
atggtctgtg ctgaccctgt ctacaaagtg tacgttgctg ctttaaaaac attgagagcc 1980
atgctggtat atactccttg ccacagttta gcggaaagaa tcaaacttca gagacttctc 2040
cagccagttg tagacaccat cctagtcaaa tgtgcagatg ccaatagccg cacaagtcag 2100
ctgtccatat caacactgtt ggaactgtgc aaaggccaag caggagagtt ggcagttggc 2160
agagaaatac taaaagctgg atccattggt attggtggtg ttgattatgt cttaaattgt 2220
attcttggaa accaaactga atcaaacaat tggcaagaac ttcttggccg cctttgtctt 2280
atagatagac tgttgttgga atttcctgct gaattttatc ctcatattgt cagtactgat 2340
gtttcacaag ctgagcctgt tgaaatcagg tataagaagc tgctgtccct cttaaccttt 2400
gctttgcagt ccattgataa ttcccactca atggttggca aactttccag aaggatctac 2460
ttgagttctg caagaatggt tactacagta ccccatgtgt tttcaaaact gttagaaatg 2520
ctgagtgttt ccagttccac tcacttcacc aggatgcgtc gccgtttgat ggctattgca 2580
gatgaggtgg aaattgccga agccatccag ttgggcgtag aagacacttt ggatggtcaa 2640
caggacagct tcttgcaggc atctgttccc aacaactatc tggaaaccac agagaacagt 2700
tcccctgagt gcacagtcca tttagagaaa actggaaaag gattatgtgc tacaaaattg 2760
agtgccagtt cagaggacat ttctgagaga ctggccagca tttcagtagg accttctagt 2820
tcaacaacaa caacaacaac aacaacagag caaccaaagc caatggttca aacaaaaggc 2880
agaccccaca gtcagtgttt gaactcctct cctttatctc atcattccca attaatgttt 2940
ccagccttgt caaccccttc ttcttctacc ccatctgtac cagctggcac tgcaacagat 3000
gtctctaagc atagacttca gggattcatt ccctgcagaa taccttctgc atctcctcaa 3060
acacagcgca agttttctct acaattccac agaaactgtc ctgaaaacaa agactcagat 3120
aaactttccc cagtctttac tcagtcaaga cccttgccct ccagtaacat acacaggcca 3180
aagccatcta gacctacccc aggtaataca agtaaacagg gagatccctc aaaaaatagc 3240
atgacacttg atctgaacag tagttccaaa tgtgatgaca gctttggctg tagcagcaat 3300
agtagtaatg ctgttatacc cagtgacgag acagtgttca ccccagtaga ggagaaatgc 3360
agattagatg tcaatacaga gctcaactcc agtattgagg accttcttga agcatctatg 3420
ccttcaagtg atacaacagt aacttttaag tcagaagttg ctgtcctgtc tcctgaaaag 3480
gctgaaaatg atgataccta caaagatgat gtgaatcata atcaaaagtg caaagagaag 3540
atggaagctg aagaagaaga agctttagca attgccatgg caatgtcagc gtctcaggat 3600
gccctcccca tagttcctca gctgcaggtt gaaaatggag aagatatcat cattattcaa 3660
caggatacac cagagactct accaggacat accaaagcaa aacaaccgta tagagaagac 3720
actgaatggc tgaaaggtca acagataggc cttggagcat tttcttcttg ttatcaggct 3780
caagatgtgg gaactggaac tttaatggct gttaaacagg tgacttatgt cagaaacaca 3840
tcttctgagc aagaagaagt agtagaagca ctaagagaag agataagaat gatgagccat 3900
ctgaatcatc caaacatcat taggatgttg ggagccacgt gtgagaagag caattacaat 3960
ctcttcattg aatggatggc agggggatcg gtggctcatt tgctgagtaa atatggagcc 4020
ttcaaagaat cagtagttat taactacact gaacagttac tccgtggcct ttcgtatctc 4080
catgaaaacc aaatcattca cagagatgtc aaaggtgcca atttgctaat tgacagcact 4140
ggtcagagac taagaattgc agattttgga gctgcagcca ggttggcatc aaaaggaact 4200
ggtgcaggag agtttcaggg acaattactg gggacaattg catttatggc acctgaggta 4260
ctaagaggtc aacagtatgg aaggagctgt gatgtatgga gtgttggctg tgctattata 4320
gaaatggctt gtgcaaaacc accatggaat gcagaaaaac actccaatca tcttgctttg 4380
atatttaaga ttgctagtgc aactactgct ccatcgatcc cttcacattt gtctcctggt 4440
ttacgagatg tggctcttcg ttgtttagaa cttcaacctc aggacagacc tccatcaaga 4500
gagctactga agcatccagt ctttcgtact acatggtagc caattatgca gatcaactac 4560
agtagaaaca ggatgctcaa caagagaaaa aaaacttgtg gggaaccaca ttgatattct 4620
actggccatg atgccactga acagctatga acgaggccag tggggaaccc ttacctaagt 4680
atgtgattga caaatcatga tctgtaccta agctcagtat gcaaaagccc aaactagtgc 4740
agaaactgta aactgtgcct ttcaaagaac tggccctagg tgaacaggaa aacaatgaag 4800
tttgcatgac taaattgcag aagcataatt ttattttttt ggagcacttt ttcagcaata 4860
ttagcggctg aggggctcag gatctatttt aatatttcaa ttattcttcc atttcatata 4920
gtgatcacaa gcagggggtt ctgcaattcc gttcaaattt tttgtcactg gctataaaat 4980
cagtatctgc ctcttttagg tcagagtatg ctatgagtag caatacatac atatattttt 5040
aaaagttgat acttctttat gacccacagt tgacctttat tttcttaaat accagggcag 5100
ttgtggctca ttgtgcattt tactgttggc ccattcattt cgtttttgga aattatggtt 5160
ttgtattttc atgtttattt acattcattt ttgtttattc agggaaagct gatctttttt 5220
tcaaaccaga aaaaaaaaat gaactagata tgaagtagag ttcattaaat atcttgctat 5280
tgtcagagtt tttaaaatat agacttaatt ttgttttttt aaattggaat acaataaagt 5340
actacctaca tttgagtcag tcaccactct tattgtgcag gttaagtaca agttaactaa 5400
aaataaactg tcctctctgg tgcaactcac aaccaagatc aagattacct taaaatttat 5460
ttgaattttt tagatgtttt ggttgtcaaa ctgtaggaaa cttcacaaca tttaagtctt 5520
actctgtatg taacaatcca tcattcacct tcactactgg tagtaacata gagctgccat 5580
tttcctttta ccatgcatca tctctttaca gtaggcctgg cagatcattt tttaaaaaga 5640
ttattcaact accaatcagt aatgttttta aacagtacat ttgctttgaa cttggaaaat 5700
gtgttcagaa agaaaaatgg aattgaattt catttataca ctaattcctt ggattttgca 5760
cagttaccta acggttttag tctggagtta aattcagatg catggaatcc tgaaggaaaa 5820
tggtagcttt ttaatctttt tgtgtgtgtg tgagtctttt aaatcaagta ctgattaact 5880
attaagtaca actttgagat tttagtttta actcttcaga agccagtgtg aaatagaatt 5940
ggttattctc aaagactcag gataaactaa ataagctata tatagagtac atttaaaatg 6000
tacaacacaa attggaaata aaataagtta caagataagt ttacagggat atattgctta 6060
caatttttaa aaggcagttt gttttttatg tgaatatgtt tcttagtgaa attttacatt 6120
cctttgtttt ggaagattgg cgatatttga agagttaaaa atagtacaga aatgtgaagt 6180
ttggtatctc taaatgtgtt gtacttgact ttctttttta ttttgttttt tttttttttt 6240
gactacttag aattttcaca attctaataa gattgtttcc aagtctctca tgtgcaagct 6300
ttaaaggatg cactcttgcc attttatgta ctggaagatc attggtcaga tgaatactgt 6360
gtctgacaaa aatgtaaact gtataaactg aggaacctca gctaatcagt attactttgt 6420
agatcaccat gcccaccaca tttcaaactc aaactatctg tagatttcaa aatccattgt 6480
gtttgagttt gtttgcagtt ccctcagctt gctggtaatt gtggtgtttt gttttttgtt 6540
ttgttttcaa tgcaaatgtg atgtaatatt cttattttct ttggatcaaa gctggactgg 6600
aaattgtatc gtgtaattat ttttgtgttc ttaatgttat ttggtactca agttgtaaat 6660
aacgtctact actgtttatt ccagtttcta ctacctcagg tgtcctatag atttttcttc 6720
taccaaagtt cactttcaca atgaaattat atttgctgtg tgactatgat tcctaagatt 6780
tccagggctt aagggctaac ttctattagc accttactgt gtaagcaaat gttacaaaaa 6840
aaaaaaaaaa aaatctctgg gttaagaaaa tttggcttaa atgtatcctt tgttatttta 6900
aatatattga gatattttaa ttaaaatttt taccccattg aaccgatttt atagtatttg 6960
tacctatttt ggtgtttttg tctttatagt aaataaaagt ttttgaacaa a 7011
<210> 10
<211> 9104
<212> DNA
<213> 智人
<400> 10
tctccctcgg cgccgccgcc gccgcccgcg gggctgggac ccgatgcggt tagagccgcg 60
gagcctggaa gagccccgag cgtttctgct ttgggacaac catacatcta attccttaaa 120
gtagttttat atgtaaaact tgcaaagaat cagaacaatg cctccacgac catcatcagg 180
tgaactgtgg ggcatccact tgatgccccc aagaatccta gtagaatgtt tactaccaaa 240
tggaatgata gtgactttag aatgcctccg tgaggctaca ttaataacca taaagcatga 300
actatttaaa gaagcaagaa aataccccct ccatcaactt cttcaagatg aatcttctta 360
cattttcgta agtgttactc aagaagcaga aagggaagaa ttttttgatg aaacaagacg 420
actttgtgac cttcggcttt ttcaaccctt tttaaaagta attgaaccag taggcaaccg 480
tgaagaaaag atcctcaatc gagaaattgg ttttgctatc ggcatgccag tgtgtgaatt 540
tgatatggtt aaagatccag aagtacagga cttccgaaga aatattctga acgtttgtaa 600
agaagctgtg gatcttaggg acctcaattc acctcatagt agagcaatgt atgtctatcc 660
tccaaatgta gaatcttcac cagaattgcc aaagcacata tataataaat tagataaagg 720
gcaaataata gtggtgatct gggtaatagt ttctccaaat aatgacaagc agaagtatac 780
tctgaaaatc aaccatgact gtgtaccaga acaagtaatt gctgaagcaa tcaggaaaaa 840
aactcgaagt atgttgctat cctctgaaca actaaaactc tgtgttttag aatatcaggg 900
caagtatatt ttaaaagtgt gtggatgtga tgaatacttc ctagaaaaat atcctctgag 960
tcagtataag tatataagaa gctgtataat gcttgggagg atgcccaatt tgatgttgat 1020
ggctaaagaa agcctttatt ctcaactgcc aatggactgt tttacaatgc catcttattc 1080
cagacgcatt tccacagcta caccatatat gaatggagaa acatctacaa aatccctttg 1140
ggttataaat agtgcactca gaataaaaat tctttgtgca acctacgtga atgtaaatat 1200
tcgagacatt gataagatct atgttcgaac aggtatctac catggaggag aacccttatg 1260
tgacaatgtg aacactcaaa gagtaccttg ttccaatccc aggtggaatg aatggctgaa 1320
ttatgatata tacattcctg atcttcctcg tgctgctcga ctttgccttt ccatttgctc 1380
tgttaaaggc cgaaagggtg ctaaagagga acactgtcca ttggcatggg gaaatataaa 1440
cttgtttgat tacacagaca ctctagtatc tggaaaaatg gctttgaatc tttggccagt 1500
acctcatgga ttagaagatt tgctgaaccc tattggtgtt actggatcaa atccaaataa 1560
agaaactcca tgcttagagt tggagtttga ctggttcagc agtgtggtaa agttcccaga 1620
tatgtcagtg attgaagagc atgccaattg gtctgtatcc cgagaagcag gatttagcta 1680
ttcccacgca ggactgagta acagactagc tagagacaat gaattaaggg aaaatgacaa 1740
agaacagctc aaagcaattt ctacacgaga tcctctctct gaaatcactg agcaggagaa 1800
agattttcta tggagtcaca gacactattg tgtaactatc cccgaaattc tacccaaatt 1860
gcttctgtct gttaaatgga attctagaga tgaagtagcc cagatgtatt gcttggtaaa 1920
agattggcct ccaatcaaac ctgaacaggc tatggaactt ctggactgta attacccaga 1980
tcctatggtt cgaggttttg ctgttcggtg cttggaaaaa tatttaacag atgacaaact 2040
ttctcagtat ttaattcagc tagtacaggt cctaaaatat gaacaatatt tggataactt 2100
gcttgtgaga tttttactga agaaagcatt gactaatcaa aggattgggc actttttctt 2160
ttggcattta aaatctgaga tgcacaataa aacagttagc cagaggtttg gcctgctttt 2220
ggagtcctat tgtcgtgcat gtgggatgta tttgaagcac ctgaataggc aagtcgaggc 2280
aatggaaaag ctcattaact taactgacat tctcaaacag gagaagaagg atgaaacaca 2340
aaaggtacag atgaagtttt tagttgagca aatgaggcga ccagatttca tggatgctct 2400
acagggcttt ctgtctcctc taaaccctgc tcatcaacta ggaaacctca ggcttgaaga 2460
gtgtcgaatt atgtcctctg caaaaaggcc actgtggttg aattgggaga acccagacat 2520
catgtcagag ttactgtttc agaacaatga gatcatcttt aaaaatgggg atgatttacg 2580
gcaagatatg ctaacacttc aaattattcg tattatggaa aatatctggc aaaatcaagg 2640
tcttgatctt cgaatgttac cttatggttg tctgtcaatc ggtgactgtg tgggacttat 2700
tgaggtggtg cgaaattctc acactattat gcaaattcag tgcaaaggcg gcttgaaagg 2760
tgcactgcag ttcaacagcc acacactaca tcagtggctc aaagacaaga acaaaggaga 2820
aatatatgat gcagccattg acctgtttac acgttcatgt gctggatact gtgtagctac 2880
cttcattttg ggaattggag atcgtcacaa tagtaacatc atggtgaaag acgatggaca 2940
actgtttcat atagattttg gacacttttt ggatcacaag aagaaaaaat ttggttataa 3000
acgagaacgt gtgccatttg ttttgacaca ggatttctta atagtgatta gtaaaggagc 3060
ccaagaatgc acaaagacaa gagaatttga gaggtttcag gagatgtgtt acaaggctta 3120
tctagctatt cgacagcatg ccaatctctt cataaatctt ttctcaatga tgcttggctc 3180
tggaatgcca gaactacaat cttttgatga cattgcatac attcgaaaga ccctagcctt 3240
agataaaact gagcaagagg ctttggagta tttcatgaaa caaatgaatg atgcacatca 3300
tggtggctgg acaacaaaaa tggattggat cttccacaca attaaacagc atgcattgaa 3360
ctgaaaagat aactgagaaa atgaaagctc actctggatt ccacactgca ctgttaataa 3420
ctctcagcag gcaaagaccg attgcatagg aattgcacaa tccatgaaca gcattagaat 3480
ttacagcaag aacagaaata aaatactata taatttaaat aatgtaaacg caaacagggt 3540
ttgatagcac ttaaactagt tcatttcaaa attaagcttt agaataatgc gcaatttcat 3600
gttatgcctt aagtccaaaa aggtaaactt tgaagattgt ttgtatcttt ttttaaaaaa 3660
caaaacaaaa caaaaatccc caaaatatat agaaatgatg gagaaggaaa aagtgatggt 3720
tttttttgtc ttgcaaatgt tctatgtttt gaaatgtgga cacaacaaag gctgttattg 3780
cattaggtgt aagtaaactg gagtttatgt taaattacat tgattggaaa agaatgaaaa 3840
tttcttattt ttccattgct gttcaattta tagtttgaag tgggtttttg actgcttgtt 3900
taatgaagaa aaatgcttgg ggtggaaggg actcttgaga tttcaccaga gactttttct 3960
ttttaataaa tcaaaccttt tgatgatttg aggttttatc tgcagttttg gaagcagtca 4020
caaatgagac ctgttataag gtggtatttt tttttttctt ctggacagta tttaaaggat 4080
cttattctta tttcccaggg aaattctggg ctcccacaaa gtaaaaaaaa aaaaaaatca 4140
tagaaaaaga atgagcagga atagttctta ttccagaatt gtacagtatt caccttaagt 4200
tgattttttt tctccttctg caattgaact gaatacattt ttcatgcatg ttttccagaa 4260
aatagaagta ttaatgttat taaaaagatt atttttttta ttaaaggcta tttatattat 4320
agaaactatc attaatatat attctttatt tacatgatct gtcccatagt catgcattgt 4380
tttgcacccc aaatttttta ttgttcatag cagcatggtc agctttcttc ttgatctata 4440
gatgaggctc aggcactatc ccatttatac caataaccag tgtataacta cttaaggaaa 4500
acataaaaac ttcatcttct ttccttttat ttcttatgtg aatctcccgt cttccattct 4560
cttttataat tgagaatgtc tcaatcatat gaaattagtt accagaatta acacaattta 4620
gactatcttc ctgattcctt aaaccccttt actgaagtat actcatgaat aatactttaa 4680
aatatggggg aatagaaacc atgaactttt taccttttta aactatttat ccatatctcc 4740
aaagtagaac attaaaccat tttaagatat gtctcattcc caagtagtca gagctcactc 4800
tccaacttta ttaaatacta tttgagcaca ggacacattc ttaaacattt tgaaaaacat 4860
taacccaaga tgtagaggct actgctagtc gtcattctag aatctgatat tttactctgt 4920
atttgaaatg aatgattaat gtcctaggaa attagcttta gcagatgtcc aggtgccaca 4980
tcaaaaaagt gcaataatta ttgacagttt tttagattag gcatattatt ggaaaacaac 5040
tttataaaga gtgaacattg tatactctag taaaacagca tcactttaaa aatattcatt 5100
tatgaaatct gttacctata gttgaagtct tgagtagtga acaagggact ctaataccaa 5160
tactcttaat atctggctat tttagatccc ttaaagggca taattattgg aaatttaggt 5220
atttcactaa agcatgtata taatattgcc aacaagaaaa gtaaatttga agattaaggg 5280
aacttacttc tgcaaactgt cttgcgatag ttaagcagaa tttaaactct gttttaagca 5340
ggaaaccaga aagattattt tgcagttgta gaagatttca taacttatta aaacttatta 5400
acattttgtg ttgtttagat ataggcagtt gatacatact aacatcccag ccttttcaat 5460
atcagggtta aattatagga aaactcagta aaatggtaca aatctgaaag tttgatggta 5520
gaaactgaag atttaacaga gaactgtgtt ttacccgagt gccaaaaatg ctgtgagcct 5580
ccttgcacaa aatttatacc acttttgcat ttttatctat cagtccagat agttgtctcc 5640
cctccttctc ccaggacctc tccaccatta aaatgcacaa accacatggc cgatttcacc 5700
atttacattt attttcaaaa gttactacaa ccaaattaat tctattagaa gaaatgtaga 5760
caaattctat aaagactata gattgtgacc taagaaagaa atgaggcaaa gaaccaaaca 5820
ttgaattaaa tgctacatgg gtgactaaga tctgtttcaa gtcagtgata atatagccac 5880
ttctgggtac ttcagtatca gagatcagtt ctcgtggttt agacagttcc tatctatagc 5940
tgactatcct tgtccttgaa tatggtgtaa ctgactattg gctctacagt tttattgggc 6000
cacttaagaa atatttcctt gaataattat tttgagaaaa agtctaaaag taataaaaat 6060
aattttaaac acactgtagt aagaaatgac tgttggaaaa ttatgctttc actttctacc 6120
atattctcag ctatacaaaa ccatttattt tgaagatttt tagactactg ttaatttgaa 6180
atctgttact cttattgtgg aatttgtttt tttaaaaaag atgtttctaa ttggattttt 6240
aaaagaagaa tggaatttgg ttgctatttt acaatagaac ctaagctttt tgtggttctt 6300
agtgtcctat gtaaaactta gtgtcaaagt aatcaacttt gagattttcc cttctattct 6360
gctttatatt aaaagcccat tagaaaatgg gaacctggtg aatatataat gaattgtaaa 6420
atattttaat gtgtaacttt ttcaactgtg aaactgactt gattttttga tgaaaacagc 6480
tgctgataaa gtattttgtg taaagtgtag ttcttattaa tcaggaaaat gatgacttga 6540
ttagactgta tatgccctct tggattttat tttaaatgga ttggtgactt tcacataggt 6600
aaaacacagt ccatctgtat tcttttttcc atcaaaaatc gagtgatttg gaattataaa 6660
aaaattgtga gcagcctatt tgaaaggcat catggaaatt tcacagcaca ataacacgga 6720
tttgtttttt cttaatgatg taaatccgtt taattcatac tttgatcaat agcccatgct 6780
tgccaactct gaagaaattt aatttccagc agtattttaa agctagcctg ttaacttttt 6840
ctgaatattt aaagttcctc ttttttctat gtctgcacaa actgcagacc tgggctggac 6900
ccacatactc aagagtccac cttaagaaat tattttgatg tccaagacat cactaaaata 6960
tttaagttta aagataatat gtggtgttaa tagattgtgg tgcttttact atttaaagac 7020
aactttcata cttcagatgt ttttgagaag aggggaatgt gaggggaggg ggcagaacag 7080
ggaggagttg tttgaatgaa ttacattctt tatatccatc ctgctcattt ggggcatgtc 7140
tttaagagaa ggctgaaagt tgtgagagta tattgtatac cgtaagagaa tcaactcttc 7200
atcatggatg ggattgtgaa ggctgaacta taaaattcag cattgacagc atcctcaatt 7260
aataattctt ggtgacagaa taatacagct gggctgtttt ttaaaatata aacaatacca 7320
tttttaatta ttacattaaa aattgtaaat atatctatgt gccatggcct gggaagcctg 7380
ctttcttttt tcataaaaat tatttttact gtatgaaaag atcatggggt ttagctcaaa 7440
atatctgtgg tcctgataaa attggattgg taactctacc tcagaaggaa aatgggaaaa 7500
aaaaatagat gagtcacaat tcaatacttc aagctcagaa actgtgcaga tcactgaatt 7560
ttagatttat aaagtcagag ttggcatgcc ttgtttttaa tgatatggaa gaccttaaga 7620
aaaaaacttg gctgaagttt aatcgttggt ccagccattt gaaaaaggca atagtttgag 7680
gaggttcccg aattcggcat ttgaaattca ttttgttctc tcttcttcat tattagtgca 7740
tttggtgtgt gtatacttgc acacaattct gtttgtgtac acactgcttg cttagcccta 7800
gtcaagaggc atcttttata aaaggtgtaa agaaatatca aggttctaaa attcggaaga 7860
gtttagaatt tattaggagt ttcccaagtt gggatgttag tctttaaata aacttcatgc 7920
acctattcca cttaaggttt tgcacctcct ttttattagt gcagtgccat ttcttctgct 7980
tgattttagg tatgttaata ttccagcctt gctagttagc ataaagtgac aggtgtgagc 8040
catgaggaaa ttttctgact taatttgtac acaactacat ataagagttt tagtggagga 8100
aaaaaattag tcccttgtgc gtatacagta gttaggtaaa tgatttttct accaacagta 8160
tactccattc ctcatgtagg taagtacaga aaaggttttt aaatgtattt ttttagccag 8220
ttaaagtcta tgaatctatc tgcaacctta tttaatctgt cactataata attttgtggt 8280
tatgctaaga accatgtata cttttaggta ttcttatttt tgtcaatttt tctaggttgg 8340
caaggaggca gaaaaccttc attgtttcat attaaaatat aattagacta aacttaattc 8400
tagtatgaat ttccaaaatc attatctatt tatttcattt ttatttaatt ttgtttttat 8460
ttcattttta aaagtccctt gttcaattta acttatgttc ctaagagagg ttggagaact 8520
tggccttcat ctgatttcaa aaatgttttg agtttcaaat gaagttaatg gtttcagtgt 8580
gattcagtcc tcagacctaa ttgggttgaa taaaatctaa aagaatatac ccttttggag 8640
cataacattt taataccttg gggaatgtgg cactaccaaa agaagactac taacacgtca 8700
gatgttcacc tggaagcttt atcaagaaat tcgaaccacc cttttggccc cattaattgt 8760
agcaagttta tttctctata ttttgtcatt cagtgaattg aagtcctgtg gtatactgca 8820
ttcattagaa gaaaaacgtt tttaatgtcc ttttaatgat ggcccagaaa gcatttgaca 8880
cagcaagatg catgtgttac tatattgaga atatagaata ataacagtat cactaaattt 8940
aagacctctt cccagtcttg ctgttcctag caagaagttt ggcctgtgac tgcacttact 9000
gtttatgctc atcagaaact gtcaatgtct gcttttcttt aactctgcag tctgtaacat 9060
cacgctgttt attaaaaaaa aaaagaaaaa ttaaaaaaaa aaaa 9104
<210> 11
<211> 480
<212> PRT
<213> 智人
<400> 11
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly
1 5 10 15
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp
20 25 30
Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg
35 40 45
Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys
50 55 60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp
65 70 75 80
Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg
85 90 95
Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys
100 105 110
Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn
115 120 125
Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg
130 135 140
Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr
145 150 155 160
Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr
165 170 175
Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val
180 185 190
Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro
195 200 205
Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys
210 215 220
Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser
225 230 235 240
Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu
245 250 255
Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr
260 265 270
Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile
275 280 285
Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala
290 295 300
Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val
305 310 315 320
Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly
325 330 335
Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln
340 345 350
Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe
355 360 365
Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu
370 375 380
Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys
385 390 395 400
Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val
405 410 415
Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu
420 425 430
Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr
435 440 445
Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu
450 455 460
Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala
465 470 475 480
<210> 12
<211> 481
<212> PRT
<213> 智人
<400> 12
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly
1 5 10 15
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp
20 25 30
Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr
35 40 45
Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys
50 55 60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp
65 70 75 80
Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg
85 90 95
Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln
100 105 110
Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser
115 120 125
Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg
130 135 140
Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys
145 150 155 160
Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg
165 170 175
Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp
180 185 190
Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg
195 200 205
His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg
210 215 220
Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His
225 230 235 240
Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly
245 250 255
Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val
260 265 270
Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His
275 280 285
Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly
290 295 300
Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu
305 310 315 320
Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu
325 330 335
Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn
340 345 350
Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg
355 360 365
Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu
370 375 380
Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala
385 390 395 400
Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp
405 410 415
Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser
420 425 430
Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile
435 440 445
Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu
450 455 460
Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg
465 470 475 480
Glu
<210> 13
<211> 399
<212> PRT
<213> 智人
<400> 13
Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser
1 5 10 15
Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro
20 25 30
Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe
35 40 45
Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn
50 55 60
Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser
65 70 75 80
Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp
85 90 95
Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala
100 105 110
Tyr Gly Ser Val Asn Lys Met Val His Lys Pro Ser Gly Gln Ile Met
115 120 125
Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln
130 135 140
Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr
145 150 155 160
Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile
165 170 175
Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val
180 185 190
Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile
195 200 205
Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys
210 215 220
Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser
225 230 235 240
Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp
245 250 255
Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro
260 265 270
Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser
275 280 285
Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg
290 295 300
Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val
305 310 315 320
Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe
325 330 335
Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu
340 345 350
Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu
355 360 365
Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile
370 375 380
Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp
385 390 395
<210> 14
<211> 1512
<212> PRT
<213> 智人
<400> 14
Met Ala Ala Ala Ala Gly Asn Arg Ala Ser Ser Ser Gly Phe Pro Gly
1 5 10 15
Ala Arg Ala Thr Ser Pro Glu Ala Gly Gly Gly Gly Gly Ala Leu Lys
20 25 30
Ala Ser Ser Ala Pro Ala Ala Ala Ala Gly Leu Leu Arg Glu Ala Gly
35 40 45
Ser Gly Gly Arg Glu Arg Ala Asp Trp Arg Arg Arg Gln Leu Arg Lys
50 55 60
Val Arg Ser Val Glu Leu Asp Gln Leu Pro Glu Gln Pro Leu Phe Leu
65 70 75 80
Ala Ala Ser Pro Pro Ala Ser Ser Thr Ser Pro Ser Pro Glu Pro Ala
85 90 95
Asp Ala Ala Gly Ser Gly Thr Gly Phe Gln Pro Val Ala Val Pro Pro
100 105 110
Pro His Gly Ala Ala Ser Arg Gly Gly Ala His Leu Thr Glu Ser Val
115 120 125
Ala Ala Pro Asp Ser Gly Ala Ser Ser Pro Ala Ala Ala Glu Pro Gly
130 135 140
Glu Lys Arg Ala Pro Ala Ala Glu Pro Ser Pro Ala Ala Ala Pro Ala
145 150 155 160
Gly Arg Glu Met Glu Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met
165 170 175
Asp Asp Arg Pro Glu Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr
180 185 190
Cys Met Pro Ala Trp Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg
195 200 205
Gly Pro Val Val Val Lys Pro Ile Pro Val Lys Gly Asp Gly Ser Glu
210 215 220
Met Asn His Leu Ala Ala Glu Ser Pro Gly Glu Val Gln Ala Ser Ala
225 230 235 240
Ala Ser Pro Ala Ser Lys Gly Arg Arg Ser Pro Ser Pro Gly Asn Ser
245 250 255
Pro Ser Gly Arg Thr Val Lys Ser Glu Ser Pro Gly Val Arg Arg Lys
260 265 270
Arg Val Ser Pro Val Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg
275 280 285
Arg Ala Pro Ser Pro Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr
290 295 300
Asn Arg Arg Val Asn Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln
305 310 315 320
Gln Ile Gly Pro Asn Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn
325 330 335
Lys Tyr Arg Val Phe Ile Gly Pro Gln Asn Cys Ser Cys Ala Arg Gly
340 345 350
Thr Phe Cys Ile His Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu
355 360 365
Glu Pro Ser Asp Pro Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu
370 375 380
Val Glu Ser Leu Phe Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile
385 390 395 400
Lys Ala Pro Ser Arg Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser
405 410 415
Asn Ser His Thr Leu Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu
420 425 430
Asn Ser Ile Lys Asp Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu
435 440 445
Gly Met Leu Asp Glu Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg
450 455 460
Asn Lys Leu His His His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg
465 470 475 480
Arg Asn Arg Glu Pro Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg
485 490 495
Ser His Asp Phe Tyr Ser His Glu Leu Ser Ser Pro Val Asp Ser Pro
500 505 510
Ser Ser Leu Arg Ala Ala Gln Gln Gln Thr Val Gln Gln Gln Pro Leu
515 520 525
Ala Gly Ser Arg Arg Asn Gln Glu Ser Asn Phe Asn Leu Thr His Tyr
530 535 540
Gly Thr Gln Gln Ile Pro Pro Ala Tyr Lys Asp Leu Ala Glu Pro Trp
545 550 555 560
Ile Gln Val Phe Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn
565 570 575
Trp Asn Val Arg Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser
580 585 590
Gly Ala Leu Leu Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly
595 600 605
Ser Ser Gly Ser Ser Pro Ser Gly Gly Ala Thr Ser Gly Ser Ser Gln
610 615 620
Thr Ser Ile Ser Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser
625 630 635 640
Met Val Cys Ala Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys
645 650 655
Thr Leu Arg Ala Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu
660 665 670
Arg Ile Lys Leu Gln Arg Leu Leu Gln Pro Val Val Asp Thr Ile Leu
675 680 685
Val Lys Cys Ala Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser
690 695 700
Thr Leu Leu Glu Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly
705 710 715 720
Arg Glu Ile Leu Lys Ala Gly Ser Ile Gly Ile Gly Gly Val Asp Tyr
725 730 735
Val Leu Asn Cys Ile Leu Gly Asn Gln Thr Glu Ser Asn Asn Trp Gln
740 745 750
Glu Leu Leu Gly Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe
755 760 765
Pro Ala Glu Phe Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala
770 775 780
Glu Pro Val Glu Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe
785 790 795 800
Ala Leu Gln Ser Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser
805 810 815
Arg Arg Ile Tyr Leu Ser Ser Ala Arg Met Val Thr Thr Val Pro His
820 825 830
Val Phe Ser Lys Leu Leu Glu Met Leu Ser Val Ser Ser Ser Thr His
835 840 845
Phe Thr Arg Met Arg Arg Arg Leu Met Ala Ile Ala Asp Glu Val Glu
850 855 860
Ile Ala Glu Ala Ile Gln Leu Gly Val Glu Asp Thr Leu Asp Gly Gln
865 870 875 880
Gln Asp Ser Phe Leu Gln Ala Ser Val Pro Asn Asn Tyr Leu Glu Thr
885 890 895
Thr Glu Asn Ser Ser Pro Glu Cys Thr Val His Leu Glu Lys Thr Gly
900 905 910
Lys Gly Leu Cys Ala Thr Lys Leu Ser Ala Ser Ser Glu Asp Ile Ser
915 920 925
Glu Arg Leu Ala Ser Ile Ser Val Gly Pro Ser Ser Ser Thr Thr Thr
930 935 940
Thr Thr Thr Thr Thr Glu Gln Pro Lys Pro Met Val Gln Thr Lys Gly
945 950 955 960
Arg Pro His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser His His Ser
965 970 975
Gln Leu Met Phe Pro Ala Leu Ser Thr Pro Ser Ser Ser Thr Pro Ser
980 985 990
Val Pro Ala Gly Thr Ala Thr Asp Val Ser Lys His Arg Leu Gln Gly
995 1000 1005
Phe Ile Pro Cys Arg Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg
1010 1015 1020
Lys Phe Ser Leu Gln Phe His Arg Asn Cys Pro Glu Asn Lys Asp
1025 1030 1035
Ser Asp Lys Leu Ser Pro Val Phe Thr Gln Ser Arg Pro Leu Pro
1040 1045 1050
Ser Ser Asn Ile His Arg Pro Lys Pro Ser Arg Pro Thr Pro Gly
1055 1060 1065
Asn Thr Ser Lys Gln Gly Asp Pro Ser Lys Asn Ser Met Thr Leu
1070 1075 1080
Asp Leu Asn Ser Ser Ser Lys Cys Asp Asp Ser Phe Gly Cys Ser
1085 1090 1095
Ser Asn Ser Ser Asn Ala Val Ile Pro Ser Asp Glu Thr Val Phe
1100 1105 1110
Thr Pro Val Glu Glu Lys Cys Arg Leu Asp Val Asn Thr Glu Leu
1115 1120 1125
Asn Ser Ser Ile Glu Asp Leu Leu Glu Ala Ser Met Pro Ser Ser
1130 1135 1140
Asp Thr Thr Val Thr Phe Lys Ser Glu Val Ala Val Leu Ser Pro
1145 1150 1155
Glu Lys Ala Glu Asn Asp Asp Thr Tyr Lys Asp Asp Val Asn His
1160 1165 1170
Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu Glu Glu Ala
1175 1180 1185
Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Asp Ala Leu Pro
1190 1195 1200
Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile Ile
1205 1210 1215
Ile Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala
1220 1225 1230
Lys Gln Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln
1235 1240 1245
Ile Gly Leu Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val
1250 1255 1260
Gly Thr Gly Thr Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg
1265 1270 1275
Asn Thr Ser Ser Glu Gln Glu Glu Val Val Glu Ala Leu Arg Glu
1280 1285 1290
Glu Ile Arg Met Met Ser His Leu Asn His Pro Asn Ile Ile Arg
1295 1300 1305
Met Leu Gly Ala Thr Cys Glu Lys Ser Asn Tyr Asn Leu Phe Ile
1310 1315 1320
Glu Trp Met Ala Gly Gly Ser Val Ala His Leu Leu Ser Lys Tyr
1325 1330 1335
Gly Ala Phe Lys Glu Ser Val Val Ile Asn Tyr Thr Glu Gln Leu
1340 1345 1350
Leu Arg Gly Leu Ser Tyr Leu His Glu Asn Gln Ile Ile His Arg
1355 1360 1365
Asp Val Lys Gly Ala Asn Leu Leu Ile Asp Ser Thr Gly Gln Arg
1370 1375 1380
Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala Arg Leu Ala Ser Lys
1385 1390 1395
Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu Leu Gly Thr Ile
1400 1405 1410
Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln Tyr Gly Arg
1415 1420 1425
Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu Met Ala
1430 1435 1440
Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His Leu
1445 1450 1455
Ala Leu Ile Phe Lys Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile
1460 1465 1470
Pro Ser His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys
1475 1480 1485
Leu Glu Leu Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu
1490 1495 1500
Lys His Pro Val Phe Arg Thr Thr Trp
1505 1510
<210> 15
<211> 1068
<212> PRT
<213> 智人
<400> 15
Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met
1 5 10 15
Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val
20 25 30
Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu
35 40 45
Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp
50 55 60
Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu
65 70 75 80
Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln
85 90 95
Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile
100 105 110
Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe
115 120 125
Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu
130 135 140
Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His
145 150 155 160
Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu
165 170 175
Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val
180 185 190
Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr
195 200 205
Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala
210 215 220
Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys
225 230 235 240
Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly
245 250 255
Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr
260 265 270
Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met
275 280 285
Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met
290 295 300
Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly
305 310 315 320
Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile
325 330 335
Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp
340 345 350
Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys
355 360 365
Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn
370 375 380
Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala
385 390 395 400
Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys
405 410 415
Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr
420 425 430
Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val
435 440 445
Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser
450 455 460
Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe
465 470 475 480
Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala
485 490 495
Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly
500 505 510
Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys
515 520 525
Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr
530 535 540
Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr
545 550 555 560
Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser
565 570 575
Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro
580 585 590
Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp
595 600 605
Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr
610 615 620
Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys
625 630 635 640
Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys
645 650 655
Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys
660 665 670
Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu
675 680 685
Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg
690 695 700
Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys
705 710 715 720
Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val
725 730 735
Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu
740 745 750
Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu
755 760 765
Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu
770 775 780
Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile
785 790 795 800
Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile
805 810 815
Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg
820 825 830
Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile
835 840 845
Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly
850 855 860
Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp
865 870 875 880
Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu
885 890 895
Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly
900 905 910
Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln
915 920 925
Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys
930 935 940
Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe
945 950 955 960
Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu
965 970 975
Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg
980 985 990
Gln His Ala Asn Leu Phe Ile Asn Leu Phe Ser Met Met Leu Gly Ser
995 1000 1005
Gly Met Pro Glu Leu Gln Ser Phe Asp Asp Ile Ala Tyr Ile Arg
1010 1015 1020
Lys Thr Leu Ala Leu Asp Lys Thr Glu Gln Glu Ala Leu Glu Tyr
1025 1030 1035
Phe Met Lys Gln Met Asn Asp Ala His His Gly Gly Trp Thr Thr
1040 1045 1050
Lys Met Asp Trp Ile Phe His Thr Ile Lys Gln His Ala Leu Asn
1055 1060 1065
<210> 16
<211> 480
<212> PRT
<213> 智人
<400> 16
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly
1 5 10 15
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp
20 25 30
Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg
35 40 45
Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys
50 55 60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp
65 70 75 80
Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg
85 90 95
Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys
100 105 110
Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn
115 120 125
Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg
130 135 140
Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr
145 150 155 160
Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr
165 170 175
Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val
180 185 190
Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro
195 200 205
Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys
210 215 220
Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser
225 230 235 240
Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu
245 250 255
Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr
260 265 270
Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile
275 280 285
Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala
290 295 300
Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val
305 310 315 320
Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly
325 330 335
Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln
340 345 350
Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe
355 360 365
Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu
370 375 380
Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys
385 390 395 400
Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val
405 410 415
Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu
420 425 430
Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr
435 440 445
Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu
450 455 460
Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala
465 470 475 480
<210> 17
<211> 481
<212> PRT
<213> 智人
<400> 17
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly
1 5 10 15
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp
20 25 30
Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr
35 40 45
Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys
50 55 60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp
65 70 75 80
Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg
85 90 95
Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln
100 105 110
Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser
115 120 125
Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg
130 135 140
Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys
145 150 155 160
Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg
165 170 175
Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp
180 185 190
Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg
195 200 205
His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg
210 215 220
Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His
225 230 235 240
Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly
245 250 255
Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val
260 265 270
Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His
275 280 285
Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly
290 295 300
Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu
305 310 315 320
Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu
325 330 335
Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn
340 345 350
Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg
355 360 365
Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu
370 375 380
Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala
385 390 395 400
Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp
405 410 415
Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser
420 425 430
Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile
435 440 445
Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu
450 455 460
Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg
465 470 475 480
Glu
<210> 18
<211> 399
<212> PRT
<213> 智人
<400> 18
Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser
1 5 10 15
Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro
20 25 30
Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe
35 40 45
Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn
50 55 60
Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser
65 70 75 80
Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp
85 90 95
Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala
100 105 110
Tyr Gly Ser Val Asn Lys Met Val His Lys Pro Ser Gly Gln Ile Met
115 120 125
Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln
130 135 140
Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr
145 150 155 160
Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile
165 170 175
Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val
180 185 190
Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile
195 200 205
Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys
210 215 220
Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser
225 230 235 240
Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp
245 250 255
Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro
260 265 270
Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser
275 280 285
Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg
290 295 300
Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val
305 310 315 320
Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe
325 330 335
Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu
340 345 350
Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu
355 360 365
Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile
370 375 380
Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp
385 390 395
<210> 19
<211> 1512
<212> PRT
<213> 智人
<400> 19
Met Ala Ala Ala Ala Gly Asn Arg Ala Ser Ser Ser Gly Phe Pro Gly
1 5 10 15
Ala Arg Ala Thr Ser Pro Glu Ala Gly Gly Gly Gly Gly Ala Leu Lys
20 25 30
Ala Ser Ser Ala Pro Ala Ala Ala Ala Gly Leu Leu Arg Glu Ala Gly
35 40 45
Ser Gly Gly Arg Glu Arg Ala Asp Trp Arg Arg Arg Gln Leu Arg Lys
50 55 60
Val Arg Ser Val Glu Leu Asp Gln Leu Pro Glu Gln Pro Leu Phe Leu
65 70 75 80
Ala Ala Ser Pro Pro Ala Ser Ser Thr Ser Pro Ser Pro Glu Pro Ala
85 90 95
Asp Ala Ala Gly Ser Gly Thr Gly Phe Gln Pro Val Ala Val Pro Pro
100 105 110
Pro His Gly Ala Ala Ser Arg Gly Gly Ala His Leu Thr Glu Ser Val
115 120 125
Ala Ala Pro Asp Ser Gly Ala Ser Ser Pro Ala Ala Ala Glu Pro Gly
130 135 140
Glu Lys Arg Ala Pro Ala Ala Glu Pro Ser Pro Ala Ala Ala Pro Ala
145 150 155 160
Gly Arg Glu Met Glu Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met
165 170 175
Asp Asp Arg Pro Glu Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr
180 185 190
Cys Met Pro Ala Trp Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg
195 200 205
Gly Pro Val Val Val Lys Pro Ile Pro Val Lys Gly Asp Gly Ser Glu
210 215 220
Met Asn His Leu Ala Ala Glu Ser Pro Gly Glu Val Gln Ala Ser Ala
225 230 235 240
Ala Ser Pro Ala Ser Lys Gly Arg Arg Ser Pro Ser Pro Gly Asn Ser
245 250 255
Pro Ser Gly Arg Thr Val Lys Ser Glu Ser Pro Gly Val Arg Arg Lys
260 265 270
Arg Val Ser Pro Val Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg
275 280 285
Arg Ala Pro Ser Pro Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr
290 295 300
Asn Arg Arg Val Asn Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln
305 310 315 320
Gln Ile Gly Pro Asn Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn
325 330 335
Lys Tyr Arg Val Phe Ile Gly Pro Gln Asn Cys Ser Cys Ala Arg Gly
340 345 350
Thr Phe Cys Ile His Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu
355 360 365
Glu Pro Ser Asp Pro Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu
370 375 380
Val Glu Ser Leu Phe Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile
385 390 395 400
Lys Ala Pro Ser Arg Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser
405 410 415
Asn Ser His Thr Leu Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu
420 425 430
Asn Ser Ile Lys Asp Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu
435 440 445
Gly Met Leu Asp Glu Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg
450 455 460
Asn Lys Leu His His His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg
465 470 475 480
Arg Asn Arg Glu Pro Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg
485 490 495
Ser His Asp Phe Tyr Ser His Glu Leu Ser Ser Pro Val Asp Ser Pro
500 505 510
Ser Ser Leu Arg Ala Ala Gln Gln Gln Thr Val Gln Gln Gln Pro Leu
515 520 525
Ala Gly Ser Arg Arg Asn Gln Glu Ser Asn Phe Asn Leu Thr His Tyr
530 535 540
Gly Thr Gln Gln Ile Pro Pro Ala Tyr Lys Asp Leu Ala Glu Pro Trp
545 550 555 560
Ile Gln Val Phe Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn
565 570 575
Trp Asn Val Arg Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser
580 585 590
Gly Ala Leu Leu Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly
595 600 605
Ser Ser Gly Ser Ser Pro Ser Gly Gly Ala Thr Ser Gly Ser Ser Gln
610 615 620
Thr Ser Ile Ser Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser
625 630 635 640
Met Val Cys Ala Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys
645 650 655
Thr Leu Arg Ala Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu
660 665 670
Arg Ile Lys Leu Gln Arg Leu Leu Gln Pro Val Val Asp Thr Ile Leu
675 680 685
Val Lys Cys Ala Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser
690 695 700
Thr Leu Leu Glu Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly
705 710 715 720
Arg Glu Ile Leu Lys Ala Gly Ser Ile Gly Ile Gly Gly Val Asp Tyr
725 730 735
Val Leu Asn Cys Ile Leu Gly Asn Gln Thr Glu Ser Asn Asn Trp Gln
740 745 750
Glu Leu Leu Gly Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe
755 760 765
Pro Ala Glu Phe Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala
770 775 780
Glu Pro Val Glu Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe
785 790 795 800
Ala Leu Gln Ser Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser
805 810 815
Arg Arg Ile Tyr Leu Ser Ser Ala Arg Met Val Thr Thr Val Pro His
820 825 830
Val Phe Ser Lys Leu Leu Glu Met Leu Ser Val Ser Ser Ser Thr His
835 840 845
Phe Thr Arg Met Arg Arg Arg Leu Met Ala Ile Ala Asp Glu Val Glu
850 855 860
Ile Ala Glu Ala Ile Gln Leu Gly Val Glu Asp Thr Leu Asp Gly Gln
865 870 875 880
Gln Asp Ser Phe Leu Gln Ala Ser Val Pro Asn Asn Tyr Leu Glu Thr
885 890 895
Thr Glu Asn Ser Ser Pro Glu Cys Thr Val His Leu Glu Lys Thr Gly
900 905 910
Lys Gly Leu Cys Ala Thr Lys Leu Ser Ala Ser Ser Glu Asp Ile Ser
915 920 925
Glu Arg Leu Ala Ser Ile Ser Val Gly Pro Ser Ser Ser Thr Thr Thr
930 935 940
Thr Thr Thr Thr Thr Glu Gln Pro Lys Pro Met Val Gln Thr Lys Gly
945 950 955 960
Arg Pro His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser His His Ser
965 970 975
Gln Leu Met Phe Pro Ala Leu Ser Thr Pro Ser Ser Ser Thr Pro Ser
980 985 990
Val Pro Ala Gly Thr Ala Thr Asp Val Ser Lys His Arg Leu Gln Gly
995 1000 1005
Phe Ile Pro Cys Arg Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg
1010 1015 1020
Lys Phe Ser Leu Gln Phe His Arg Asn Cys Pro Glu Asn Lys Asp
1025 1030 1035
Ser Asp Lys Leu Ser Pro Val Phe Thr Gln Ser Arg Pro Leu Pro
1040 1045 1050
Ser Ser Asn Ile His Arg Pro Lys Pro Ser Arg Pro Thr Pro Gly
1055 1060 1065
Asn Thr Ser Lys Gln Gly Asp Pro Ser Lys Asn Ser Met Thr Leu
1070 1075 1080
Asp Leu Asn Ser Ser Ser Lys Cys Asp Asp Ser Phe Gly Cys Ser
1085 1090 1095
Ser Asn Ser Ser Asn Ala Val Ile Pro Ser Asp Glu Thr Val Phe
1100 1105 1110
Thr Pro Val Glu Glu Lys Cys Arg Leu Asp Val Asn Thr Glu Leu
1115 1120 1125
Asn Ser Ser Ile Glu Asp Leu Leu Glu Ala Ser Met Pro Ser Ser
1130 1135 1140
Asp Thr Thr Val Thr Phe Lys Ser Glu Val Ala Val Leu Ser Pro
1145 1150 1155
Glu Lys Ala Glu Asn Asp Asp Thr Tyr Lys Asp Asp Val Asn His
1160 1165 1170
Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu Glu Glu Ala
1175 1180 1185
Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Asp Ala Leu Pro
1190 1195 1200
Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile Ile
1205 1210 1215
Ile Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala
1220 1225 1230
Lys Gln Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln
1235 1240 1245
Ile Gly Leu Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val
1250 1255 1260
Gly Thr Gly Thr Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg
1265 1270 1275
Asn Thr Ser Ser Glu Gln Glu Glu Val Val Glu Ala Leu Arg Glu
1280 1285 1290
Glu Ile Arg Met Met Ser His Leu Asn His Pro Asn Ile Ile Arg
1295 1300 1305
Met Leu Gly Ala Thr Cys Glu Lys Ser Asn Tyr Asn Leu Phe Ile
1310 1315 1320
Glu Trp Met Ala Gly Gly Ser Val Ala His Leu Leu Ser Lys Tyr
1325 1330 1335
Gly Ala Phe Lys Glu Ser Val Val Ile Asn Tyr Thr Glu Gln Leu
1340 1345 1350
Leu Arg Gly Leu Ser Tyr Leu His Glu Asn Gln Ile Ile His Arg
1355 1360 1365
Asp Val Lys Gly Ala Asn Leu Leu Ile Asp Ser Thr Gly Gln Arg
1370 1375 1380
Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala Arg Leu Ala Ser Lys
1385 1390 1395
Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu Leu Gly Thr Ile
1400 1405 1410
Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln Tyr Gly Arg
1415 1420 1425
Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu Met Ala
1430 1435 1440
Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His Leu
1445 1450 1455
Ala Leu Ile Phe Lys Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile
1460 1465 1470
Pro Ser His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys
1475 1480 1485
Leu Glu Leu Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu
1490 1495 1500
Lys His Pro Val Phe Arg Thr Thr Trp
1505 1510
<210> 20
<211> 1068
<212> PRT
<213> 智人
<400> 20
Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met
1 5 10 15
Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val
20 25 30
Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu
35 40 45
Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp
50 55 60
Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu
65 70 75 80
Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln
85 90 95
Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile
100 105 110
Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe
115 120 125
Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu
130 135 140
Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His
145 150 155 160
Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu
165 170 175
Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val
180 185 190
Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr
195 200 205
Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala
210 215 220
Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys
225 230 235 240
Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly
245 250 255
Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr
260 265 270
Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met
275 280 285
Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met
290 295 300
Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly
305 310 315 320
Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile
325 330 335
Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp
340 345 350
Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys
355 360 365
Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn
370 375 380
Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala
385 390 395 400
Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys
405 410 415
Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr
420 425 430
Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val
435 440 445
Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser
450 455 460
Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe
465 470 475 480
Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala
485 490 495
Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly
500 505 510
Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys
515 520 525
Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr
530 535 540
Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr
545 550 555 560
Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser
565 570 575
Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro
580 585 590
Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp
595 600 605
Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr
610 615 620
Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys
625 630 635 640
Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys
645 650 655
Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys
660 665 670
Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu
675 680 685
Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg
690 695 700
Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys
705 710 715 720
Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val
725 730 735
Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu
740 745 750
Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu
755 760 765
Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu
770 775 780
Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile
785 790 795 800
Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile
805 810 815
Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg
820 825 830
Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile
835 840 845
Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly
850 855 860
Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp
865 870 875 880
Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu
885 890 895
Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly
900 905 910
Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln
915 920 925
Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys
930 935 940
Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe
945 950 955 960
Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu
965 970 975
Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg
980 985 990
Gln His Ala Asn Leu Phe Ile Asn Leu Phe Ser Met Met Leu Gly Ser
995 1000 1005
Gly Met Pro Glu Leu Gln Ser Phe Asp Asp Ile Ala Tyr Ile Arg
1010 1015 1020
Lys Thr Leu Ala Leu Asp Lys Thr Glu Gln Glu Ala Leu Glu Tyr
1025 1030 1035
Phe Met Lys Gln Met Asn Asp Ala His His Gly Gly Trp Thr Thr
1040 1045 1050
Lys Met Asp Trp Ile Phe His Thr Ile Lys Gln His Ala Leu Asn
1055 1060 1065

Claims (15)

1.一种治疗患有癌症的患者的方法，该方法包括：
(a)在代表该癌症且先前从该患者分离的样品中，确定PI3K通路的上游组分的基因状态是野生型还是突变型；
(b)确定该样品中的MAP3K1基因是野生型还是突变型；
(c)确定该样品中的MAP2K4基因是野生型还是突变型；并且
(d)向该患者给予有效量的PI3K通路的上游组分的抑制剂，如果：
(i)该PI3K通路的上游组分的基因状态被确定为是突变型；
(ii)该MAP3K1基因被确定为是野生型；并且
(iii)该MAP2K4基因被确定为是野生型。
2.如权利要求1所述的方法，其中该PI3K通路的上游组分选自PIK3CA、PIK3CB、PIK3CD、PIK3CG、AKT1、AKT2、AKT3、PTEN、PDK1、SGK、INPP4B、INPP5D、PIK3R1和PIK3R2。
3.如权利要求2所述的方法，其中该PI3K通路的上游组分是AKT1、AKT2、和/或AKT3。
4.如权利要求1-3中任一项所述的方法，其中该癌症是乳腺癌、胃癌、食管癌、肺癌、头颈癌、子宫内膜癌、卵巢癌、子宫颈癌、外阴癌、多发性骨髓瘤、淋巴瘤、白血病、膀胱癌、脑癌、结肠直肠癌、胆囊癌、胆管癌、皮肤癌、胰腺癌、睾丸癌、甲状腺癌、肾癌、肝癌、外阴癌、阴茎癌或其他PI3-激酶依赖性癌症。
5.如权利要求4所述的方法，其中该癌症是乳腺癌。
6.如权利要求1-5中任一项所述的方法，其中该抑制剂是4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基-丙基]-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺。
7.一种治疗患有癌症的患者的方法，该方法包括：
(a)确定该患者的癌细胞中的AKT基因是野生型还是突变型；
(b)确定该患者的癌细胞中的MAP3K1基因是野生型还是突变型；
(c)确定该患者的癌细胞中的MAP2K4基因是野生型还是突变型；
(d)向该患者给予有效量的AKT抑制剂，如果这些癌细胞具有：
(i)突变型AKT基因；
(ii)野生型MAP3K1基因；和
(iii)野生型MAP2K4基因。
8.如权利要求7所述的方法，其中该抑制剂是4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基-丙基]-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺。
9.PI3K通路的上游组分的抑制剂用于治疗癌症的用途，其中这些癌细胞具有在PI3K通路的上游组分中的突变、野生型MAP3K1基因和野生型MAP2K4基因。
10.如权利要求9所述的用途，其中该PI3K通路的上游组分是AKT1、AKT2、和/或AKT3。
11.如权利要求9-10中任一项所述的方法，其中该抑制剂是4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基-丙基]-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺。
12.一种用于取消选择患有癌症的患者进行治疗的方法，该方法包括：
鉴定患有对用PI3K通路的上游组分的抑制剂的治疗具有潜在易感性的癌症的候选患者；并且
确定先前从该候选患者分离的代表该癌症的样品中的MAP3K1和MAP2K4基因是野生型还是突变型；
其中，如果这些癌细胞具有突变型MAP3K1或MAP2K4基因，则取消选择该患者用PI3K通路的上游组分的抑制剂进行治疗。
13.如权利要求12所述的方法，其中该PI3K通路的上游组分是AKT1、AKT2、和/或AKT3。
14.一种治疗患者体内的癌症的方法，该患者的PI3K通路的上游组分以及MAP3K1和MAP2K4的癌细胞基因状态已经被确定，该方法包括：如果这些癌细胞具有在PI3K通路的上游组分中的突变、野生型MAP3K1基因和野生型MAP2K4基因，则向该患者给予有效量的该PI3K通路的上游组分的抑制剂。
15.如权利要求14所述的方法，其中该PI3K通路的上游组分是AKT1、AKT2、和/或AKT3。
CN201680051358.4A 2015-09-17 2016-09-16 用于治疗癌症的新颖生物标记和方法 Pending CN108026587A (zh)

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Cited By (5)

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CN111304326A (zh) * 2020-02-22 2020-06-19 四川省人民医院 检测及靶向lncRNA生物标志物的试剂及其在肝细胞癌中的应用
CN111334580A (zh) * 2020-04-16 2020-06-26 中山大学达安基因股份有限公司 Pik3ca基因突变检测试剂盒
CN113151472A (zh) * 2021-04-28 2021-07-23 北华大学 胃癌诊断标志物及其应用
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