KR101600278B1 - 히스타민 h4 수용체의 다이아미노-피리딘, 피리미딘, 및 피리다진 조절제 - Google Patents
히스타민 h4 수용체의 다이아미노-피리딘, 피리미딘, 및 피리다진 조절제 Download PDFInfo
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- KR101600278B1 KR101600278B1 KR1020117000733A KR20117000733A KR101600278B1 KR 101600278 B1 KR101600278 B1 KR 101600278B1 KR 1020117000733 A KR1020117000733 A KR 1020117000733A KR 20117000733 A KR20117000733 A KR 20117000733A KR 101600278 B1 KR101600278 B1 KR 101600278B1
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- South Korea
- Prior art keywords
- amine
- methylamino
- pyrimidin
- pyridin
- pyrrolidin
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- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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| Application Number | Priority Date | Filing Date | Title |
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| US6103908P | 2008-06-12 | 2008-06-12 | |
| US61/061,039 | 2008-06-12 | ||
| US11442508P | 2008-11-13 | 2008-11-13 | |
| US11441608P | 2008-11-13 | 2008-11-13 | |
| US61/114,416 | 2008-11-13 | ||
| US61/114,425 | 2008-11-13 |
Publications (2)
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| KR20110017441A KR20110017441A (ko) | 2011-02-21 |
| KR101600278B1 true KR101600278B1 (ko) | 2016-03-08 |
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| KR1020117000733A Expired - Fee Related KR101600278B1 (ko) | 2008-06-12 | 2009-06-11 | 히스타민 h4 수용체의 다이아미노-피리딘, 피리미딘, 및 피리다진 조절제 |
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| JP (1) | JP5658662B2 (https=) |
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Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007117399A2 (en) | 2006-03-31 | 2007-10-18 | Janssen Pharmaceutica N.V. | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor |
| BRPI0915720A2 (pt) | 2008-06-12 | 2015-08-04 | Janssen Pharmaceutica Nv | Moduladores de diaminopiridina, pirimidina, e piridazina do receptor de histamina h4 |
| BRPI0915526A2 (pt) * | 2008-06-12 | 2016-01-26 | Janssen Pharmaceutica Nv | uso de um antagonista da histamina h4 para o tratamento de aderências pós-operatórias |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| CN102438993A (zh) * | 2009-05-19 | 2012-05-02 | 陶氏益农公司 | 用于控制真菌的化合物和方法 |
| WO2011078143A1 (ja) * | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| RU2014150494A (ru) * | 2012-05-30 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Пирролидиногетероциклы |
| PT2964229T (pt) | 2013-03-06 | 2020-03-23 | Janssen Pharmaceutica Nv | Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina |
| WO2014147586A1 (en) * | 2013-03-22 | 2014-09-25 | Novartis Ag | 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh |
| EP3055301B1 (en) * | 2013-10-07 | 2019-11-20 | Kadmon Corporation, LLC | (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases |
| ES2741831T3 (es) | 2014-07-31 | 2020-02-12 | Basf Se | Proceso para la preparación de pirazoles |
| KR102585412B1 (ko) | 2015-05-11 | 2023-10-05 | 바스프 에스이 | 4-아미노-피리다진의 제조 방법 |
| WO2018071687A1 (en) * | 2016-10-13 | 2018-04-19 | The Regents Of The University Of California | Methods of treating pruritis |
| WO2018082964A1 (en) | 2016-11-04 | 2018-05-11 | Basf Se | Process for the production of pyridazinyl-amides in a one-pot synthesis |
| JP2022165429A (ja) * | 2019-10-02 | 2022-11-01 | Meiji Seikaファルマ株式会社 | ヒスタミンh4受容体調節作用を有する新規トリアジン誘導体 |
| MX2024000273A (es) * | 2021-07-01 | 2024-01-31 | Aerie Pharmaceuticals Inc | Azetidinil pirimidinas y usos de las mismas. |
| CN116354937B (zh) * | 2021-12-27 | 2025-07-11 | 江苏恩华药业股份有限公司 | 吡啶(嘧啶)胺类衍生物及其应用 |
| CA3260763A1 (en) * | 2022-06-29 | 2024-01-04 | Alcon Inc. | AZETIDINYL PYRIMIDINES AND THEIR USES AS JAK INHIBITORS |
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| WO2007141571A2 (en) | 2006-06-05 | 2007-12-13 | Merck Sharp & Dohme Limited | Aminothiazole derivatives as inhibitors of mark |
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| HK1002235A1 (en) | 1989-12-28 | 1998-08-07 | Pharmacia & Upjohn Company | Diaromatic substituted anti-aids compounds |
| US5449676A (en) * | 1991-04-26 | 1995-09-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridazines |
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| WO2008031556A2 (en) * | 2006-09-12 | 2008-03-20 | Ucb Pharma, S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
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| WO2008074445A1 (en) | 2006-12-18 | 2008-06-26 | Ucb Pharma, S.A. | Novel tricyclic and heterotricyclic derivatives, processes for preparing them, pharmaceutical compositions thereof |
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| EP2144877A1 (en) | 2007-04-04 | 2010-01-20 | UCB Pharma, S.A. | Novel pyridine derivatives, processes for preparing them, pharmaceutical compositions thereof |
| WO2009068512A1 (en) | 2007-11-30 | 2009-06-04 | Palau Pharma, S. A. | 2 -amino-pyrimidine derivatives as histamine h4 antagonists |
| AR072084A1 (es) | 2008-06-12 | 2010-08-04 | Sanofi Aventis | Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica como inhibidores de las quinasas pim |
| BRPI0915720A2 (pt) | 2008-06-12 | 2015-08-04 | Janssen Pharmaceutica Nv | Moduladores de diaminopiridina, pirimidina, e piridazina do receptor de histamina h4 |
| SI2356123T1 (sl) | 2008-11-13 | 2013-01-31 | F. Hoffmann-La Roche Ag | Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni |
| JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
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2009
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- 2009-06-11 CN CN200980131846.6A patent/CN102118969B/zh not_active Expired - Fee Related
- 2009-06-11 AU AU2009257434A patent/AU2009257434B2/en not_active Ceased
- 2009-06-11 EA EA201170005A patent/EA018198B1/ru not_active IP Right Cessation
- 2009-06-11 WO PCT/US2009/047033 patent/WO2009152325A1/en not_active Ceased
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2010
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2011
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2014
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2017
- 2017-06-28 US US15/636,325 patent/US20170298022A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007141571A2 (en) | 2006-06-05 | 2007-12-13 | Merck Sharp & Dohme Limited | Aminothiazole derivatives as inhibitors of mark |
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| AU2009257434B2 (en) | 2014-12-11 |
| IL209593A0 (en) | 2011-01-31 |
| EP2315521A1 (en) | 2011-05-04 |
| US20170298022A1 (en) | 2017-10-19 |
| US20140357614A1 (en) | 2014-12-04 |
| HK1157569A1 (en) | 2012-07-06 |
| PE20110061A1 (es) | 2011-01-31 |
| EP2315521B1 (en) | 2014-05-21 |
| CO6321192A2 (es) | 2011-09-20 |
| MX2010013726A (es) | 2011-01-14 |
| KR20110017441A (ko) | 2011-02-21 |
| US20110092474A1 (en) | 2011-04-21 |
| ZA201100298B (en) | 2012-06-27 |
| CN102118969A (zh) | 2011-07-06 |
| CA2727684C (en) | 2017-01-31 |
| US9732087B2 (en) | 2017-08-15 |
| CA2727684A1 (en) | 2009-12-17 |
| CN102118969B (zh) | 2017-03-08 |
| NI201000214A (es) | 2011-08-01 |
| EA018198B1 (ru) | 2013-06-28 |
| JP2011524363A (ja) | 2011-09-01 |
| ECSP10010675A (es) | 2011-01-31 |
| WO2009152325A1 (en) | 2009-12-17 |
| IL209593A (en) | 2015-02-26 |
| BRPI0915720A2 (pt) | 2015-08-04 |
| US8841287B2 (en) | 2014-09-23 |
| AU2009257434A1 (en) | 2009-12-17 |
| EP2315521A4 (en) | 2012-04-25 |
| MY158927A (en) | 2016-11-30 |
| EA201170005A1 (ru) | 2011-08-30 |
| CR20110029A (es) | 2011-07-06 |
| NZ589532A (en) | 2012-02-24 |
| JP5658662B2 (ja) | 2015-01-28 |
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