CN102118969B - 组胺h4受体的二氨基吡啶、二氨基嘧啶和二氨基哒嗪调节剂 - Google Patents
组胺h4受体的二氨基吡啶、二氨基嘧啶和二氨基哒嗪调节剂 Download PDFInfo
- Publication number
- CN102118969B CN102118969B CN200980131846.6A CN200980131846A CN102118969B CN 102118969 B CN102118969 B CN 102118969B CN 200980131846 A CN200980131846 A CN 200980131846A CN 102118969 B CN102118969 B CN 102118969B
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- Prior art keywords
- amine
- methylamino
- pyrrolidin
- pyrimidin
- pyridin
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- 0 CN(C1)CC1N(*)* Chemical compound CN(C1)CC1N(*)* 0.000 description 9
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- LMGMAZHTWLCFFM-UHFFFAOYSA-N C(CC1C2)C2CC1Nc1nccc(N2CCNCC2)n1 Chemical compound C(CC1C2)C2CC1Nc1nccc(N2CCNCC2)n1 LMGMAZHTWLCFFM-UHFFFAOYSA-N 0.000 description 1
- ODDFZMBCXMJJQX-UHFFFAOYSA-N C(CC1C2)C2CC1Nc1nncc(N2CCNCCC2)c1 Chemical compound C(CC1C2)C2CC1Nc1nncc(N2CCNCCC2)c1 ODDFZMBCXMJJQX-UHFFFAOYSA-N 0.000 description 1
- FFHYOTOGQOXQPD-UHFFFAOYSA-N C(CNc1nccc(N2CCCC2)c1)c1ccccc1 Chemical compound C(CNc1nccc(N2CCCC2)c1)c1ccccc1 FFHYOTOGQOXQPD-UHFFFAOYSA-N 0.000 description 1
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- BROFGQDXVACYPP-MIGSVPMKSA-N CC1(C)C2C(CNc3nccc(N(CC4)C[C@@H]4N)n3)CCC1C2 Chemical compound CC1(C)C2C(CNc3nccc(N(CC4)C[C@@H]4N)n3)CCC1C2 BROFGQDXVACYPP-MIGSVPMKSA-N 0.000 description 1
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- FYWWTWHYFTWIRD-ZDUSSCGKSA-N CN[C@@H](CC1)CN1c1cc(NC2CCCC2)ncc1 Chemical compound CN[C@@H](CC1)CN1c1cc(NC2CCCC2)ncc1 FYWWTWHYFTWIRD-ZDUSSCGKSA-N 0.000 description 1
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- LZABSKVJZGMKQU-JTQLQIEISA-N CN[C@@H](CC1)CN1c1nc(NC2CC2)ncc1 Chemical compound CN[C@@H](CC1)CN1c1nc(NC2CC2)ncc1 LZABSKVJZGMKQU-JTQLQIEISA-N 0.000 description 1
- HFBXVWPBZRXZSP-SNVBAGLBSA-N CN[C@H](CC1)CN1c1cc(NCCCO)nnc1 Chemical compound CN[C@H](CC1)CN1c1cc(NCCCO)nnc1 HFBXVWPBZRXZSP-SNVBAGLBSA-N 0.000 description 1
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- MNAQKNMQPXWADC-TZMCWYRMSA-N C[C@H](c1ccccc1)Nc1nccc(N(CC2)C[C@@H]2N)n1 Chemical compound C[C@H](c1ccccc1)Nc1nccc(N(CC2)C[C@@H]2N)n1 MNAQKNMQPXWADC-TZMCWYRMSA-N 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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| US61/114416 | 2008-11-13 | ||
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| PCT/US2009/047033 WO2009152325A1 (en) | 2008-06-12 | 2009-06-11 | Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor |
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| CN102118969A CN102118969A (zh) | 2011-07-06 |
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| PL2007752T3 (pl) | 2006-03-31 | 2011-02-28 | Janssen Pharmaceutica Nv | Benzoimidazol-2-ilopirymidyny i pirazyny jako modulatory receptora histaminowego H4 |
| MX2010013726A (es) | 2008-06-12 | 2011-01-14 | Janssen Pharmaceutica Nv | Moduladores de diamino-piridina, pirimidina, y piridazina del receptor h4 de histamina. |
| MX2010013727A (es) * | 2008-06-12 | 2011-01-14 | Janssen Pharmaceutica Nv | Uso de un antagonista h4 de histamina para el tratamiento de adherencias postoperatorias. |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| MX2011012343A (es) * | 2009-05-19 | 2011-12-14 | Dow Agrosciences Llc | Compuestos y metodos para controlar hongos. |
| WO2011078143A1 (ja) * | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| MX2014014308A (es) * | 2012-05-30 | 2015-02-12 | Hoffmann La Roche | Pirrolidino heterociclos. |
| SMT202000084T1 (it) | 2013-03-06 | 2020-03-13 | Janssen Pharmaceutica Nv | Modulatori benzoimidazol-2-il pirimidinici del recettore h4 dell'istamina |
| WO2014147586A1 (en) * | 2013-03-22 | 2014-09-25 | Novartis Ag | 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh |
| CN104903312B (zh) * | 2013-10-07 | 2019-01-29 | 卡德门企业有限公司 | Rho激酶抑制剂 |
| CN106573893B (zh) | 2014-07-31 | 2020-06-09 | 巴斯夫欧洲公司 | 制备吡唑的方法 |
| CA3187499A1 (en) | 2015-05-11 | 2016-11-17 | Eric George KLAUBER | Process for preparing 4-amino-pyridazines |
| US20190216790A1 (en) * | 2016-10-13 | 2019-07-18 | The Regents Of The University Of California | Methods for Treating Pruritis |
| WO2018082964A1 (en) | 2016-11-04 | 2018-05-11 | Basf Se | Process for the production of pyridazinyl-amides in a one-pot synthesis |
| JP2022165429A (ja) * | 2019-10-02 | 2022-11-01 | Meiji Seikaファルマ株式会社 | ヒスタミンh4受容体調節作用を有する新規トリアジン誘導体 |
| JP2024525368A (ja) * | 2021-07-01 | 2024-07-12 | エアリー ファーマシューティカルズ インコーポレイテッド | アゼチジニルピリミジンおよびその使用 |
| CN116354937B (zh) * | 2021-12-27 | 2025-07-11 | 江苏恩华药业股份有限公司 | 吡啶(嘧啶)胺类衍生物及其应用 |
| CA3260763A1 (en) * | 2022-06-29 | 2024-01-04 | Alcon Inc. | AZETIDINYL PYRIMIDINES AND THEIR USES AS JAK INHIBITORS |
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| WO2007072163A2 (en) * | 2005-12-20 | 2007-06-28 | Pfizer Limited | Pyrimidine derivatives |
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| CA2346659A1 (en) * | 1998-10-06 | 2000-04-13 | Michiyo Gyoten | Condensed pyridazine compounds, their production and use |
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| AR072084A1 (es) | 2008-06-12 | 2010-08-04 | Sanofi Aventis | Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica como inhibidores de las quinasas pim |
| PT2356123E (pt) | 2008-11-13 | 2012-10-31 | Hoffmann La Roche | Espiro-5,6-di-hidro-4h-2,3,5,10b-tetra-azabenzo[ e]azulenos |
| JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005054239A1 (en) * | 2003-12-05 | 2005-06-16 | Bayer Healthcare Ag | 2-aminopyrimidine derivatives |
| WO2007072163A2 (en) * | 2005-12-20 | 2007-06-28 | Pfizer Limited | Pyrimidine derivatives |
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| US20170298022A1 (en) | 2017-10-19 |
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| CA2727684A1 (en) | 2009-12-17 |
| CN102118969A (zh) | 2011-07-06 |
| KR20110017441A (ko) | 2011-02-21 |
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| JP2011524363A (ja) | 2011-09-01 |
| KR101600278B1 (ko) | 2016-03-08 |
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| CO6321192A2 (es) | 2011-09-20 |
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