KR101571523B1 - 심혈관 질환과 연관된 유전적 감수성 변이 - Google Patents

심혈관 질환과 연관된 유전적 감수성 변이 Download PDF

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KR101571523B1
KR101571523B1 KR1020097019455A KR20097019455A KR101571523B1 KR 101571523 B1 KR101571523 B1 KR 101571523B1 KR 1020097019455 A KR1020097019455 A KR 1020097019455A KR 20097019455 A KR20097019455 A KR 20097019455A KR 101571523 B1 KR101571523 B1 KR 101571523B1
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cardiovascular disease
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KR20090117896A (ko
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안나 헬가도티어
굿마 쏘어레이프슨
안드레이 마놀레스큐
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디코드 제네틱스 이에이치에프
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020097019455A 2007-02-21 2008-02-21 심혈관 질환과 연관된 유전적 감수성 변이 Expired - Fee Related KR101571523B1 (ko)

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Application Number Priority Date Filing Date Title
IS8613 2007-02-21
IS8613 2007-02-21
IS8640 2007-04-30
IS8640 2007-04-30
IS8701 2007-12-21
IS8701 2007-12-21

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KR20090117896A KR20090117896A (ko) 2009-11-13
KR101571523B1 true KR101571523B1 (ko) 2015-11-24

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US (2) US9617597B2 (enExample)
EP (2) EP2471954B1 (enExample)
JP (1) JP5646179B2 (enExample)
KR (1) KR101571523B1 (enExample)
CN (1) CN101668865B (enExample)
AU (1) AU2008218542B2 (enExample)
BR (1) BRPI0807927A2 (enExample)
CA (1) CA2679581C (enExample)
DK (1) DK2471954T3 (enExample)
EA (1) EA022610B1 (enExample)
HU (1) HUE030996T2 (enExample)
IL (1) IL200453A (enExample)
MX (1) MX2009008878A (enExample)
NZ (1) NZ579445A (enExample)
SG (1) SG178811A1 (enExample)
WO (1) WO2008102380A1 (enExample)

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US7883851B2 (en) * 2007-05-02 2011-02-08 Board Of Regents, The University Of Texas System Common allele on chromosome 9 associated with coronary heart disease
CN101978269A (zh) 2008-01-18 2011-02-16 哈佛大学校长及研究员协会 在体液中检测疾病或病症标志的方法
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ES2623633T3 (es) 2009-06-09 2017-07-11 Gendiag.Exe, S.L. Marcadores de riesgo para enfermedad cardiovascular
SG10201403152QA (en) 2009-06-15 2014-08-28 Cardiodx Inc Determination of coronary artery disease risk
CN103038352B (zh) * 2010-06-15 2015-12-16 萨拉基尼克有限公司 用于增强基因表达的新型基因间元件
CA2806304A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
WO2012012725A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting diseases or conditions using phagocytic cells
KR20130041961A (ko) 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액에서 질환 또는 상태의 특징을 검출하는 방법
US20130184178A1 (en) 2010-07-23 2013-07-18 President And Fellows Of Harvard College Methods of Detecting Autoimmune or Immune-Related Diseases or Conditions
WO2012012709A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting cardiovascular diseases or conditions
WO2012066582A1 (en) * 2010-11-18 2012-05-24 Decode Genetics Ehf Genetic risk factors of sick sinus syndrome
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CN104603289A (zh) 2012-06-15 2015-05-06 哈里·斯泰利 检测疾病或病状的方法
US20150141260A1 (en) 2012-06-15 2015-05-21 Harry Stylli Methods of detecting diseases or conditions using circulating diseased cells
MD707Z (ro) * 2013-01-18 2014-07-31 Институт Зоологии Академии Наук Молдовы Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric
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ES2733920T3 (es) * 2013-04-26 2019-12-03 Univ Kyoto Composición que comprende un agonista del receptor 1 de esfingosina-1-fosfato para inhibir la formación y/o el aumento de tamaño de un aneurisma cerebral o para reducirlo
KR101602688B1 (ko) 2013-12-30 2016-03-11 가톨릭관동대학교산학협력단 microRNA-365 활성화제를 포함하는 혈관평활근세포 증식 또는 이동 억제용 약학적 조성물
CN104946731B (zh) * 2014-03-28 2019-12-20 中国中医科学院中药研究所 快速检测金银花的pcr试剂盒及检测方法
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CN106811520A (zh) * 2016-08-17 2017-06-09 上海易瑞生物科技有限公司 一种心肌梗死易感基因检测分型试剂盒及其应用
RU2693997C2 (ru) * 2017-12-04 2019-07-08 Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) Способ определения степени предрасположенности к сердечно-сосудистым заболеваниям
CN108342472A (zh) * 2018-04-13 2018-07-31 东华大学 一种冠心病易感基因检测分型试剂盒
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CN113767179A (zh) * 2018-12-13 2021-12-07 国立研究开发法人国立循环器病研究中心 脑梗塞发病风险预测方法
CN109486940A (zh) * 2018-12-25 2019-03-19 北京北基医学检验实验室有限公司 一种扩增颅内动脉肿瘤相关基因的引物组及检测试剂盒
CN109628577A (zh) * 2019-01-07 2019-04-16 杭州艾迪康医学检验中心有限公司 检测冠状动脉硬化相关单核苷酸多态性位点的引物和方法
KR102158720B1 (ko) * 2019-04-03 2020-09-22 한림대학교 산학협력단 Lrrc3 유전자의 단일염기다형성을 포함하는 뇌동맥류 진단용 snp 마커
KR102158714B1 (ko) * 2019-04-03 2020-09-22 한림대학교 산학협력단 Tcf24 유전자의 단일염기다형성을 포함하는 뇌동맥류 진단용 snp 마커
US12100480B2 (en) 2019-08-27 2024-09-24 The Board Of Trustees Of The Leland Stanford Junior University Assessment of polygenic trait risk via trait components and applications thereof
RU2719914C1 (ru) * 2019-12-06 2020-04-23 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ прогнозирования исходов операций коронарного шунтирования
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CN113484453B (zh) * 2021-07-07 2022-08-09 天津中医药大学 一种缺血性脑卒中预警方法
CN114672548B (zh) * 2022-03-10 2024-04-19 华捷生物科技(青岛)有限公司 一种人类静脉血栓风险基因pai-1，thbd和proc基因多态性检测试剂盒及其制备方法和应用
WO2023205243A1 (en) * 2022-04-19 2023-10-26 The Regents Of The University Of Michigan Determining risk of fibromuscular dysplasia and systems and methods of use thereof
CN116144743B (zh) * 2022-12-16 2024-10-22 东华大学 基于多重长pcr结合高通量测序同时实现多个同源序列snp分型的引物、试剂盒及方法

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JP2010518848A (ja) 2010-06-03
EP2115172A1 (en) 2009-11-11
CN101668865B (zh) 2015-05-06
SG178811A1 (en) 2012-03-29
AU2008218542B2 (en) 2014-06-26
HUE030996T2 (en) 2017-06-28
EA200970781A1 (ru) 2010-04-30
WO2008102380A1 (en) 2008-08-28
CA2679581C (en) 2020-12-22
NZ579445A (en) 2012-02-24
CA2679581A1 (en) 2008-08-28
EP2471954A1 (en) 2012-07-04
DK2471954T3 (en) 2016-09-12
MX2009008878A (es) 2009-08-28
CN101668865A (zh) 2010-03-10
US20120208709A1 (en) 2012-08-16
BRPI0807927A2 (pt) 2014-06-24
US9617597B2 (en) 2017-04-11
IL200453A (en) 2014-12-31
JP5646179B2 (ja) 2014-12-24
EA022610B1 (ru) 2016-02-29
KR20090117896A (ko) 2009-11-13
IL200453A0 (en) 2010-04-29
US20100068705A1 (en) 2010-03-18
EP2471954B1 (en) 2016-08-24
AU2008218542A1 (en) 2008-08-28

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