KR100909709B1

KR100909709B1 - 골밀도 및 골절 위험과 ｉｔｇａ１ 유전자 다형성과의연관성

Info

Publication number: KR100909709B1
Application number: KR1020070031413A
Authority: KR
Inventors: 김형래; 오범석; 이종영; 이혜자; 김기수; 고정민; 김신윤; 박의균
Original assignee: 대한민국
Priority date: 2007-03-30
Filing date: 2007-03-30
Publication date: 2009-07-30
Also published as: KR20080088742A

Abstract

본 발명은 ITGA1 유전자 다형성과 골다공증과의 연관성에 관한 것이다. 본 발명에 따르면, ITGA1 유전자의 단일염기다형성 (SNP) +73187C>T (엑손 3), +76969T>G (인트론 5) 또는 +159174A>C (인트론 28), 또는 일배체형 블록 (haplotype LD) 중 BL1_ht1, BL1_ht2, BL2_ht3 또는 BL3_ht1은 골다공증의 지표인 골밀도 및 골절 위험과 밀접한 관련이 있으며, 이를 마커로 이용하여 골다공증의 유전적 소인을 사전에 예측할 수 있다.

ITGA1 (Integrin Alpha1) 유전자, 폐경기, 단일염기다형성, 일배체형 블록 (haplotype LD), 골절, 골밀도 (Bone mineral density)

Description

골밀도 및 골절 위험과 ＩＴＧＡ１ 유전자 다형성과의 연관성 {Association of ITGA1 gene polymorphisms with bone mineral density and fracture risk}

도 1a는 염색체 5q11.2 (Ref. Genome Seq. NT_006431) 상의 ITGA1 유전자의 동정된 다형성들을 나타낸 것이다.

도 1b는 ITGA1 다형성들 사이의 연관 불평형 계수 LD 및 LD 블록들을 나타낸 것이다.

도 1c는 ITGA1의 일배체형의 빈도를 나타낸 것이다.

도 2a 내지 도 2d는 본 발명에서 ITGA1의 다형성들의 크로마토그램들을 도시한 것이다.

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기술분야

본 발명은 척추 골절 위험 및 골밀도와 관련된 다형성에 관한 것이다. 보다 상세하게는, 본 발명은 척추 골절 위험 및 골밀도와 관련된 ITGA1 유전자 다형성 마커에 관한 것이다.

종래기술

골다공증은 낮은 골밀도 (BMD) 및 증가된 골절 위험도를 특징으로 하는 전신성 골질환이다 (상기 문헌: 1). 다양한 위험 인자가 골밀도 및 골다공증의 발병에 영향을 미치나, 유전인자가 주요 요인의 하나로서, 쌍둥이 및 가족 연구에 따르면 상이한 BMD의 50~85%는 이들 유전인자에 의해 설명된다 (상기 문헌: 2 내지 8). 병리학적 상태에서, 조골세포에 의한 골 형성과 비교하여 파골세포에 의한 높은 골 손실율은 골 리모델링의 불균형을 초래한다. 따라서, 파골세포의 분화 및 기능과 관련된 유전자는 BMD 및 골다공증에 대한 유전적 영향을 밝히는데 있어 잠재적 후보이다.

파골세포의 골 인식은 인테그린에 의해 조절되며 (상기 문헌: 9 및 10), 인테그린은 긴 세포외 도메인과 상대적으로 짧은 세포내 도메인을 지닌 α-서브유닛 및 β-서브유닛으로 구성된 트랜스멤브레인 단백질이다 (상기 문헌: 9 내지 11). 이들 α/β-복합체는 무작위로 결합하는 부분과 특정 지역에 결합하는 부분으로 구성되며, 각 인테그린 패밀리는 무작위로 결합하는 부분에 따라 명명된다. 세포-표면 수용체로서 인테그린은 콜라겐, 피브로넥틴 및 라미닌에 의해 제공되는 세포-부착 부위를 선택적으로 인식한다. 인테그린 계열에서, α1β1 인테그린은 콜라겐 타입 I의 단량체 형태 (monomeric form) 및 이형삼량체 콜라겐 타입 IV에 인테그린-타입 콜라겐 수용체는 세포주위 콜라겐 원섬유 형성을 유도하거나 촉진하기까지 한다 (상기 문헌: 34 및 35). 세포외 기질의 주요 성분과 결합하는 인테그린은 추간판 조직 (intervertebral disc tissue) 및 관절 연골에서 발현된다 (상기 문헌: 36). 인테그린과 세포외 기질의 상호작용은 골절 치료 및 연골 리모델링에 있어 중요하다 (상기 문헌: 15 및 16). 그러나, 골다공증과 인테그린의 관련성이 보고된 바는 없다.

ITGA1 유전자는 β-1 사슬과 함께 하나의 이형이량체를 형성하여 신경세포 및 조혈세포에서 이중 라미닌/콜라겐 (laminin/collagen) 수용체로서 기능한다 (상기 문헌: 12 내지 14). 이것은 라미닌 및 콜라겐에 대한 세포 결합 및 신경돌기 성장, 및 말초신경 재생에 작용한다. 적절한 콜라겐-인테그린 상호작용은 골절 치료에서 중요하며, ITGA1 유전자가 중간엽 줄기세포 증식 및 연골 생성에 관여함을 제시한다 (상기 문헌: 15). ITGA1 유전자는 막투과성 이형이량체 유전자 (transmembrane heterodimer genes) 계열의 하나로서, 29개의 엑손을 포함하고 5q11.2 염색체 상에서 165 kb 이상의 크기를 갖는다 (상기 문헌: 33). 제미오 등 (Zemmyo et al.) (상기 문헌: 16)은 ITGA1-유전자 제거 마우스의 무릎 관절을 4 내지 15 월령의 야생형 마우스의 무릎 관절과 비교하였다. ITGA1-유전자 제거 마우스는 상대적으로 심각한 연골 손상, 글리코사민 손상 및 활막성 관절 과다증식 (synovial hyperplasia)을 보였다. 본 발명자들은 ITGA1 서브유닛이 골관절염성연골에 있어 조기 재생 과정에 관련되는 것으로 추정하였다. 몇몇 공통된 단일염기변이 (SNPs)는 질환과 관련된 반면, 다른 것들은 관련이 없다. 또한, 유전적 다양성은 상당한 민족적 차이가 있다. 본 발명자들은 골다공증 표현형에 대한 ITGA1 위치의 유전적 감수성을 조사하였다. 그 결과 ITGA1 다형성 마커들이 골다공증의 지표인 골밀도 및 골절 위험과 유의성 있는 연관성을 가짐을 확인함으로써 본 발명을 완성하였다.

본 발명은 골절 위험 및 골밀도와 연관성을 갖는 ITGA1 다형성 마커를 제공하는 것을 목적으로 한다.

또한 본 발명은 골다공증 예측에 유용한 일배체형 (haplotype) 마커 (marker)를 제공하는 것을 목적으로 한다.

본 발명의 목적은 피검자로부터 상기 다형성을 검출하는 방법 및 이로써 피 검자의 골절 또는 골다공증 감수성을 예측하는 방법, 및 이를 위한 키트를 제공하는 것이다.

상기 목적을 달성하기 위해, 본 발명자들은 946명의 한국 폐경기 여성을 대상으로 골다공증에 대한 유전적 감수성을 연구 하였다. 본 발명자들은 골 파라미터와 ITGA1 다형성 간의 연관성 및 이들의 일배체형 (haplotype) 연관 불균형 블록을 연구하였다.

본 발명자들은 직접 시퀀싱으로 165-kb ITGA1 영역으로부터 61개의 유전자 다형성을 확인하였다 (n = 24 명, 피검자 수). 이 영역에서의 일배체형 블록 (haplotype LD) 다양성을 평가하고 HapMap 데이터베이스와 비교하였다. 8개의 SNPs를 지노타이핑 하고 폐경기 여성에서 이들의 잠재적 관련성을 추가로 조사하였다 (n = 946 명).

다양한 대퇴골 부위 (femur sites)에서, SNPs, 즉 +73187C>T (엑손 3) 및 +76969T>G (인트론 5)와 이들의 BL_hts가 골밀도 (BMD)와 연관성을 나타냈다 (p = 0.009-0.05). 또한 +159174A>C (인트론 28) 및 이것의 일배체형 BL3_ht1 은 골절 위험도와 매우 유의성 있는 연관성을 나타냈다 (p = 0.003-0.005).

일 구체예에서, 본 발명은 골다공증 및 골절 위험도와 연관성을 갖는 ITGA1 다형성 마커를 제공한다. 본 발명자들은 24명으로부터 고도로 보존된 사람 유전자 ITGA1 유전자에서 61개의 다형성을 확인하였다. 8개의 다형성을 선택하고, 946명의 폐경기 여성에서 지노타이핑하여 ITGA1 유전자와 골다공증 표현형과의 관련성을 연구 하였다. 통계분석 결과, ITGA1+159174A>C (인트론 28), +164104C>T (3' UTR) 및 BL3_ht1 은 비-척추 골절의 위험도와 현저한 관련성이 있었다 (표 7 참조). SNP +159174A>C (인트론 28) 및 이것의 일배체형 BL3_ht1 는 골절 위험도와 가장 유력하게 관련성을 가졌다 (p = 0.003-0.005). BL3_ht1의 SNPs 중 마이너 대립유전자 ITGA1 +159174A>C 는 또한 골절과 현저한 관련성이 있으며, 이것의 동형접합자는 공동 동형접합자 보다 대퇴골부위의 골밀도와 높은 관련성을 갖는다. +159174A>C 의 마이너 대립유전자 (C) 및 이것의 메이져 일배체형 BL3_ht1 (C-C-T, 빈도 = 0.457)은 공동우성 (p = 0.005, OR = 0.65, 95% CI = 0.48-0.88) 및 우성 (p = 0.003, OR = 0.53, 95% CI = 0.35-0.80) 모델에서 골절 위험도에 대해 높은 보호 효과를 가졌다. 일배체형 BL3_ht1 (C-C-T)의 빈도는 정상의 대조군에서 0.465, 골절 환자에서 0.359를 나타냈다. 그러나, 마이너 대립유전자, (T) +164104C>T, 는 공동 우성 모델에서 골절 위험도에 민감하였다 (p = 0.03, OR = 1.52, 95% CI = 0.94-1.82).

다시 말해서, 본 발명은 골다공증에 대한 감수성을 예측하기 위한 ITGA1 유전자 다형성 마커를 발굴하고자 하였으며, 상기 유전자 다형성 마커로서 ITGA1 유전자의 단일염기다형성 중 +73187C>T (엑손 3), +76969T>G (인트론 5), 또는 이들의 일배체형 BL1_ht1 또는 BL1_ht2를 제공한다. 여기서, BL1_ht1는 ITGA1 유전자의 번역개시점으로부터 +73187번째 염기가 C이고 +76969번째 염기가 T이며; BL1_ht2는 ITGA1 유전자의 번역개시점으로부터 +73187번째 염기가 T이고 +76969번째 염기가 G이며, 상기 유전자 다형성 마커는 대퇴골 경부 및 대퇴골 간체의 BMD와 연관되어 있다.

또한 본 발명은 골다공증에 대한 감수성을 예측하기 위한 ITGA1 유전자 다형성 마커로서, ITGA1 유전자의 단일염기다형성 중 +159174A>C (인트론 28) 또는 이의 BL3_ht1을 제공한다. 여기서, BL3_ht1는 ITGA1 유전자의 번역개시점으로부터 +159174번째 염기가 C이고 +164104번째 염기가 C이고 +165697번째 염기가 T이며, 상기 유전자 다형성 마커는 골절 위험도와 연관되어 있다.

또한 본 발명은 골다공증에 대한 감수성을 예측하기 위한 ITGA1 유전자 다형성 마커로서, 상기 유전자 다형성 마커가 ITGA1 유전자의 일배체형 블록 (haplotype LD) 중 BL2_ht3를 제공한다. 여기서, BL2_ht3는 ITGA1 유전자의 번역개시점으로부터 +109100번째 염기가 T이고 +110140번째 염기가 G이고, +130991번째 염기가 C이며, 상기 유전자 다형성 마커는 와드 삼각부의 BMD와 연관되어 있다.

일구체에서 본 발명은 (1) 개체로부터 DNA 샘플을 수득하는 단계; (2) 단계 (1)에서 수득한 DNA에서 본 발명의 유전자 다형성 마커를 검출하는 단계; 및 (3) 단계 (2)에서 검출된 다형성 마커를 확인하는 단계를 포함하는, 골다공증에 대한 감수성을 예측하는 방법을 제공한다.

일구체에서 본 발명은 본 발명의 유전자 다형성 마커의 서열변이 스크리닝용 프라이머, 및 지노타이핑용 프라이머 및 프로브를 포함하는 골다공증에 대한 감수성 예측용 키트를 제공한다. 여기서, 스크리닝용 프라이머는 서열번호: 1 내지 서열번호: 62로 구성되고, 지노타이핑용 프라이머 및 프로브가 서열번호: 63 내지 서열번호: 93으로 구성된다.

본 명세서에서 다형성 부위의 뉴클레오티드 위치는 ITGA1의 번역개시점을 +1로 계산한 것이다. 따라서, 본 명세서의 ITGA1+159174A>C 및 +164104C>T 에서 +159174는 ITGA1의 번역개시점으로부터 +159174번째 임을 나타낸다. 또, A>C는 상기 다형성 부위에서 메이져 (major) 대립유전자는 A이고 마이너 (minor) 대립유전자는 C임을 나타낸다. 추가로, 예컨대, +73187C>T (C92C)란 ITGA1의 번역개시점으로부터 +73187번째에 존재하는 염기에 있어서 메이져 대립유전자는 C이고 마이너 대립유전자는 T라는 것이고 이의 번역후 단백질 서열에 있어서는 92번째 위치에 메이져 대립유전자의 경우에는 C (즉, Cys)로 번역되고 마이너 대립유전자의 경우에는 C (즉, Cys)로 번역됨을 의미한다.

이하, 본 발명을 하기 실시예에 의거하여 더욱 상세히 설명한다. 하기 실시예는 본 발명을 예시하고자 하는 것으로, 본 발명을 제한하고자 하는 것은 아니다. 본 발명에 개시된 모든 문헌은 참조로서 통합된다.

실시예

실시예 1: 피검자의 선정

한국 서울의 아산 병원 (Asan Medical Center, AMC)을 방문한 한국 폐경기 여성 946명을 연구 대상으로 하였다 (표 1 참조). 폐경기는 적어도 6개월 이상 생리가 없는 것으로 정의하였고, 혈청 내 여포자극호르몬을 측정하여 확인하였다. 폐경기 초기 여성 (40세 미만)은 제외하였다. 골 대사에 영향을 미치는 약물을 6개월 이상 복용하거나 실험 이전 12개월 내에 복용한 적이 있는 여성을 제외하였다. 골 대사에 영향을 줄 수 있는 병력이 있는 피검자도 실험에서 제외하였다. 물리적 행동 장애의 우려가 있는 졸중 또는 치매 병력의 여성은 제외하였다. 또한 나단 분류 (Nathan Classification)에서 4등급을 넘는 골증식체 형성이 있는 여성 및/또는 통상의 척추 방사선 사진에서 확인되는 요추 내 후관절 고관절염을 가진 여성은 제외하였다. 모든 실험은 아산병원 윤리위원회의 허가를 받은 것이며 모든 피검자들로부터 서면 동의를 얻었다.

표 1. 폐경기 한국인 여성의 임상 프로파일 (n = 946)

637명의 여성에 대해 면적 골밀도 (BMD) (g/cm²) 전-후 요추 (L2-L4) 및 근위 대퇴골 [대퇴골 경부 (femoral neck), 대퇴골 간체(femoral shaft), 전체 대퇴골 (total femur), 전자 (trochanter) 및 워드 삼각부 (Ward's triangle)]를 이중-에너지 방사선 흡수계측기 (dual-energy X-ray absorptiometry) (Lunar Expert XL with software version 1.90, Madison, WI, USA)를 사용하여 측정하였다. 309명의 여성에서, BMD를 Hologic QDR 4500-A (software version 4.84, Waltham, MA, USA)을 사용하여 측정하였다. 질병관리본부에서, 요추 및 대퇴골 간체의 골밀도만을 2001년1월 이전에 측정하였고, Hologic 장비는 대퇴골 간체의 골밀도 측정에는 사용되지 않았다. 따라서, 946명의 피검자 중 대퇴골 간체에서의 골밀도 및 다른 근위 대퇴골 [전체 대퇴골 (total femur), 전자 (trochanter) 및 워드 삼각부 (Ward's triangle)] 골밀도는, 각각 331명 및 452명에서 측정한 자료이다. 상지 우성에 기초하여, 근위 대퇴부에서 BMD를 비우성 부위에서 측정하였다. Lunar 및 Hologic 장비의 단기 생체 내 측정 정밀도 (변수의 계수로서 표현)는 요추에서 각각 0.82% 및0.85% 였고, 대퇴골 간체에서 각각 1.12% 및 1.20% 이었다. 이들 값은 본 실험에 참여하지 않은 17명의 지원자를 스캐닝하여 수득한 값이다. 이들 지원자는 같은 날 5차례 스캐닝을 수행했다. 2개 시스템간 교차-보정 공식을 유도하기 위해, 건강한 한국 여성 109명 (평균: 55 세 및 표준편차: 11 세, 연령 범위 31 ~ 75세)에 대해 요추 및 대퇴골 간체에서 골밀도 값을 측정하고, 교차-보정 공식을 아래와 같이 설정하였다:

L2-4 BMD (g/cm²): Lunar = 1.1287 x Hologic - 0.0027

대퇴골 간체 BMD (g/cm²): Lunar = 1.1556 x Hologic + 0.0182

그러나, 교차-보정 값은 한국 여성의 다른 부위 (전자, 전체 대퇴골, 워드 삼각부)에서는 여전히 사용할 수 없었으므로, 본 발명자들은 유전적 다양성과 골밀도 값의 연관성을 공변수로서 측정 장비의 통계적 조정을 사용하여 분석하였다. 모든 피검자로부터 측부 흉요추 (Lateral thoracolumbar) (T4-L4) 방사선 사진을 수득하였다. 척추 골절은 WGVF (The Working Group on Vertebral Fractures)의 권고에 따라 평가하였다 (상기 문헌: 19). 척추 골절 (vertebral fracture)은 교통 사고와 같은 중대한 외상의 병력을 지닌 자를 제외한 피검자에서 척추 부위의 전, 후 또는 중간 높이에서 15% 이상의 골 손실을 갖는 것으로 정량적으로 정의했다. 또한, 50세 이후 엉덩이 또는 손목과 같은 비-척추 골절 위험성의 병력에 대해서는 중대한 외상이 없었던 피검자로부터 자기 응답 설문조사를 통해 수집하였다. 교통사고, 추락과 같은 주요 외상에 의한 명백한 골절은 제외하였다.

실시예 2: 사람 ITGA1 의 시퀀싱 분석

본 발명자들은 24명의 한국인 DNA 샘플에서 단일염기변이 (SNPs)를 검출하기 위해 ABI PRISM 3730 DNA 분석기(Applied Biosystems, Foster City, CA)를 사용하여 엑손-인트론 경계를 포함하는 모든 엑손 및 프로모터 영역 (~1.5 kb)을 시퀀싱 하였다. GenBank 서열 (Ref. Seq. of ITGA1 mRNA: NM_181501 및 contig: NT_006431)에 기초하여 증폭 및 시퀀싱 분석을 위한 31개의 프라이머 세트를 디자 인 하고 다중서열정렬을 통해 SNPs를 검출했다. 프라이머 세트는 표 2 (서열번호: 1 내지 서열번호: 62)와 같다.

표 2. ITGA1 다형성 발견을 위한 프라이머 서열

실시예 3: 지노타이핑 및 형광 편광 검출

다형성 부위 지노타이핑을 위해, TaqMan에 대한 증폭 프라이머 및 프로브를 디자인 했다. 프라이머 익스프레스 (Applied Biosystems)를 사용하여 PCR 프라이머 및 MGB TaqMan 프로브를 디자인 하였다 (표 3 참조, 서열번호: 63 내지 서열번호: 93). 하나의 대립유전자 프로브를 FAM (5-carboxy fluorscein) 염색으로 표지하고 다른 대립유전자는 형광 VIC (등록상표명) 염색으로 표지하였다. 우라실-N-글리코실라제 (uracil-N-glycosylase)가 없는 TaqMan Universal Master mix (Applied Biosystems)를 사용하고 900 nM의 PCR 프라이머 및 200 nM의 TaqMan MGB-프로브를 사용하여 PCR 반응을 수행했다. 반응은 20 ng 의 유전자 DNA를 사용하고 총 5 L 양으로 384-웰에서 수행했다. 다음, 플레이트를 써멀 사이클러 (PE 9700, Applied Biosystems)로 옮기고 50 ℃에서 2분 및 95 ℃ 에서 10분 가열한 후, 95 ℃에서 15초 및 60 ℃에서 1분 씩 가열하는 것을 40회 반복 수행했다. TaqMan 어세이 플레이트를 Prism 7900HT 장비 (Applied Biosystems)로 옮겨 각 웰의 형광강도를 측정했다. 각 플레이트로부터 수득한 형광 데이터 파일을 자동화된 소프트웨어 (SDS 2.2)를 사용하여 분석하였다 (도 2a 내지 도 2d).

표 3. ITGA1 SNP 지노타이핑을 위한 TaqMan 검출 프라이머 및 프로브의 서열

실시예 4: 통계 분석

χ²테스트를 통해 개체군의 각 좌위에서의 개체변이를 확인하였다 (하디-바이베르크 평형). 본 발명자들은 모든 복대립 유전자 좌위의 유전자 쌍들간의 르원튼 D'(Lewontin's D') (|D'|) 및 연관불평형 (linkage disequilibrium) (LD) 계수 r ² 를 조사했다. LD 블록의 구조를 조사하기 위해 Haploview version 3.2 (Whitehead Institute for Biomedical Research, Cambridge, Mass.)를 사용하였다. 이 프로그램은 D' 및 LOD 값이 유도되는 4개 배우자 빈도 값 (gamete frequencies values)의 최대-가능성 값을 추정하기 위해 2-마커 기대 최대화를 이용한다. 각 개체의 일배체형을 스테판 등 (상기 문헌: 25)에 의해 개발된 PHASE 알고리즘을 사용하여 유추하였다. PHASE 알고리즘은 개체군 유전적 특징 및 융합이론에 기초하는 일배체형 구조의 우선기대치를 통합한 베이지안 접근법 (Bayesian approach)을 사용한다. PHASE 소프트웨어 (ver 2.0)를 사용하여 각 개체에 대해 모든 일배체형 다형성 부위의 패이즈 확률을 계측했다. 97% 미만의 패이즈 확률을 갖는 개체는 분석에서 제외하였다. 유추된 해플로타입의 유전적 효과를 다형성과 같은 방법으로 분석하였다. 연령 (연속변수), 폐경이후 연차 (YSM; 연속변수), 체중, 신장, 및/또는 공변수로서 측정 장비의 유형을 조절하면서 다중회귀분석을 BMD에 대해 수행했다. 우성 동형접합자, 이형 접합자, 및 열성 동형접합자에 대해, 공동우성, 우성 및 열성 모델에서 각각 0, 1 및 2; 0, 1 및 1; 및 0, 0 및 1의 코드를 부여했다. 일배체형 연관성을 샤이드 등 (상기 문헌: 26)이 개발한 알고리즘 (Haplo.Score and Haplo.GLM)을 이용하여 분석하였다.

실시예 5: 키트

본 발명에 따른 골다공증 및 골절 위험의 예측과 연관된 일배체형 마커 또는 다형성 마커를 이용하여, 본 발명은 ITGA1 유전자의 일배체형 마커인 BL3_ht1 의 서열변이 스크리닝용 프라이머 세트를 포함하는 골다공증 및 골절 위험 예측용 키트를 제공한다. 상기 프라이머 세트는 상기 표 2 및 표 3에 기재되어 있다.

결과

한국인 집단 (n=24명)으로부터 염색체 5q11.2에 위치하는 165 kb의 ITGA1 를 직접 시퀀싱 하였으며, 모든 엑손, 이들의 인트론 경계 부위 및 5' 플랭킹 영역의 ~1.5 kb를 포함하도록 하였다. 61개의 다형성을 확인하였다: 프로모터 영역에서 5개, 인트론에서 31개, 코딩영역에서 7개, 3' 비번역 영역에서 13개, 및 내재 영역 (intergenic region)에서 5개 (프라이머 서열: 표 2, 크로마토그램: 도 2a 내지 도 2d, 발견된 다형성 및 이들의 빈도: 표 4a 내지 표 4d). 61개의 다형성은 하디-와인버그 평형 상태에 있었다. 웹사이트 (http://www.ncbi.nlm.nih.gov/projects/SNP/)의 데이터와 비교한 결과, 13개는 새로운 것으로 밝혀졌다. 한국인에서 발견한 모든 SNP 데이터를 KSNP database (http://www.ngri.re.kr/SNP)에 등록하였다.

표 4a. ITGA1 다형성의 빈도

표 4b. ITGA1 다형성의 빈도 (계속)

표 4c. ITGA1 다형성의 빈도 (계속)

표 4d. ITGA1 다형성의 빈도 (계속)

61개 SNPs중 0.05 초과 (>0.05)의 마이너 대립유전자 빈도를 갖는 48개의 다형성을 사용하여 한국인 피검자의 일배체형 블록 (haplotype LD) 패턴을 분석하였다. 이들 48 SNPs 는 공간상 균일하게 분포되어 있지 않았다 (도 1a). 도 1a는 ITGA1의 유전자 지도로서, 화살표는 염색체 5q11.2상의 ITGA1에서 동정되고 지노타이핑된 다형성들의 위치를 나타내며, 다형성들의 빈도는 괄호안에 기재하였고 (Ref. Genome Seq. NT_006431), 엑손은 흑색 상자로 표시하고 5' 및 3' 비번역 영 역은 백색 상자로 표시하였으며, 번역개시부위의 제 1 염기를 뉴클레오타이드 +1으로 표시하였다. 이 영역에서 LD 패턴을 조사하기 위해, Haploview version 3.2를 사용하여 마커의 모든 페어-와이즈 조합간에 LD의 두 값 (D' 및 r²)을 분석하였다. 5q11.2 염색체 상의 165kb에 이르는 LD 블록이 전체 ITGA1 유전자를 포함했다. 이것의 플랭킹 영역은 확인되지 않았으나, 이 영역에서 두개의 작은 LD 블록과 하나의 큰 LD 블록이 있음이 LD 패턴에서 관찰되었다. 또한, 이 영역 내 LD를 전체 사람 게놈에 걸쳐 LD의 분포와 범위를 제시하는 HapMap 데이터베이스와 비교하였다.

한국 폐경기 여성 (n=946명)에서의 연관성 분석을 위해, 높은 마이너 대립유전자 빈도를 갖는 8개의 SNP를 선정하고, ITGA1 다형성과 BMD의 관련성을 분석하기 위해 지노타이핑 하였다 (표 3 참조). 피검자의 임상정보 및 연령, YSM, 체중 및 키와 BMDs 및 골절과의 상관관계에 대한 자료는 표 1에 나타냈다. 피검자의 평균 연령은 58.9 ± 7.5세 (44~84 세 사이)였고, 평균 YSM은 9.6 ± 7.9 년 (1~34년)이었다. 예상했던 것과 같이, 연령과 YSM은 흉요추 및 대퇴골 경부에서의 BMD와 음성적으로 상관관계에 있었다. 신장은 흉요추 BMD와 양성적으로 상관관계에 있었다. Lunar 장비 (흉부 요추 및 대퇴골 경부에서 각각 0.887 ± 0.145 g/cm² 및 0.734 ± 0.105 g/cm²)로 측정한 BMDs는 Hologic 장비(각각 0.785 ± 0.092 g/cm² 및 0.608 ± 0.067 g/cm²; 둘 모두에 대해 p < 0.0001)로 측정한 값보다 현저히 높았다. 그러나. 교차-보정 공식을 적용한 결과 측정값이 크게 다르지 않았다 (결과 제시하지 아니함); 이와 같이, 연령, YSM, 체중 및 키를 흉요추 및 퇴골 경부에서 BMD와의 연관성에 대한 다중 회귀 분석에서 공동변수로서 사용하였다. 그러나, 교차-보정 데이터는 다른 부위 (전체 대퇴골, 전자, 대퇴골 간체 및 워드 삼각부)에서 한국 여성에 적용될 수 없으므로, 본 발명자들은 BMD 값과 유전적 다양성의 연관성을 분석함에 있어 골밀도 검사를 추가의 공변수로서 이용하였다.

본 발명자들은 61개 다형성 중, 8개 SNPs를 946명의 폐경기 후 한국인 여성에서 지노타이핑 하고, 일배체형 블록 (haplotype LD)를 분석했다 (표 5 및 도 1b). 도 1b에서 적색 사각형은 D' 통계학에 의해 측정된, SNPs의 쌍 사이의 통계학적으로 유의성있는 대립유전자 연관성을 나타내며 적색의 음영들은 짙을 수록 최대 1까지의 더 높은 D' 값을 나타낸다.

표 5. 946명의 폐경기 한국인 피검자에서 ITGA1 다형성 빈도

^a 한국인 폐경기 피검자에서 하디-와인버그 평형으로부터 편차 P 값

각 SNP의 빈도를 상기 표 5에 나타냈다 지노타입 분포는 하디-와인버그 평형에 있었다 (p > 0.05). ITGA1에 있어, 3개의 BL_hts를 Haploview version 3.2 (상기 문헌: 22) 및 르원틴 방법으로 구성하였다 (상기 문헌: 21) (도 1b). 각 블록에서 공통 일배체형(빈도 0.1 초과)은 99.7, 83.9 및 90.6% 이었으며 (도 1c), BL_hts는 추가의 통계 분석에 이용하였다. 도 1c에서 4가지 일배체형이 91.8% 이상의 분포를 차지하고 있으며, 기타 (Others)는 CAT, CGC, TAT 및 CGT이다.

어떠한 다형성도 흉요추에서 BMD와 현저한 연관성을 나타내지 않았다 (자료 제시 안함). 그러나 ITGA1 +73187C>T (엑손 3)와 +76969T>G (인트론 5) 및 이들의 일배체형은 BL1_ht1 및 BL1_ht2는 대퇴골 경부 및 다른 근위 대퇴골 부위 (femur sites), 대퇴골 간체의 BMD와 연관성을 나타냈다 (표 6).

표 6. 폐경기 한국 여성에서 대퇴골 경부 및 근위 대퇴골 간체 부위의 BMDs와 ITGA1 다형성 및 일배체형과의 연관성

상기 표 6는 연령, 체중, 신장 및 폐경이후 경과 연차에 대해 보정한 후에 유전자형 분포, BMD 값 평균 및 표준 편차 (SD), 및 3가지 대안 모델 (Pa: 공동-우성, Pb: 우성, Pc: 열성)의 회귀 분석에 의한 p-값을 나타낸 것이다. 일배체형 연관성에 대한 p-값은 샤이드 (상기 문헌: 26)에 의해 개발된 알고리즘으로 계산되었다. 상기 표 6에서 C는 공통 대립유전자 R은 희귀 대립유전자를 나타내며, Pa, Pb 및 Pc는 공동우성, 우성 및 열성 모델에서의 P-값들을 가르킨다.

그러나, ITGA1 +73187C>T (엑손 3) 및 +76969T>G (인트론 5) 및 이들의 일배체형 BL1_ht1 및 BL1_ht2 는 퇴골 경부 및 대퇴골체에서 BMD와 연관성을 나타냈다. SNP +73187C>T (엑손 3)은 대퇴골 경부 BMD의 열성모델에서 0.01의 p-값을 나타냈고, 대퇴골 간체의 우성모델에서 0.04의 p-값을 나타냈다. SNP +76969T>G (인트론 5)에서, p-값은 대퇴골 경부 BMD 열성모델 및 대퇴골 간체 우성모델 모두에서 0.04를 나타냈다. 마이너 동형접합체 +73187C>T (TT, 0.99 ± 0.17 g/cm²) 또는 이형접합체 (CT, 1.01 ± 0.17 g/cm²) 인자형을 지닌 피검자는, 메이저 동형접합체 (CC)를 지닌 피검자와 비교하여 대퇴골 간체에 대해 보다 더 높은 BMD를 가졌다 (0.93 ± 0.19 g/cm²). 또한, 메이저 동형접합체, (TT) + 76969T>G,를 지닌 피검자는 대퇴골 간체에서 보다 더 낮은 평균 BMD (0.92 ± 0.19 g/cm²)를 가졌다. 블록 2의 일배체형은 대퇴골 경부, 와드 삼각부 (Ward's triangle) 및 전자 (trochanter)와 연관되었다 (자료 제시 안함). 특히, BL2_ht3 (T-G-C) 는 와드 삼각부 BMD의 우성모델 회귀분석에서 유의성을 나타냈다 (p = 0.009).

척추 및 비척추 골절이 각각 126명 및 107명의 피검자에서 확인되었다. 어떠한 다형성도 척추 골절과 관련성이 없었다 (결과 제시하지 않음). 그러나, ITGA1+159174A>C (인트론 28), +164104C>T (3' UTR) 및 BL3_ht1 은 비-척추 골절의 위험도와 현저한 관련성이 있었다 (표 7).

표 7. 폐경기 한국 여성에서 비-척추 골절의 위험성과 ITGA1 다형성 및 일배체형과의 연관성

상기 표 7은 공변수로서 연령, 체중, 신장, 폐경 이후 경과 연차 및 골밀도 측정기를 제어한 후에 골절이 있거나 없는 피검자에서의 유전자형 빈도, 및 3가지 대안 모델 (공동우성, 우성 및 열성)의 로지스틱 분석에 대한 p-값(하단 설명)을 나타낸 것이다. 일배체형 연관성에 대한 p-값은 샤이드 (상기 문헌: 26)에 의해 개발된 알고리즘으로 계산되었다.

SNP +159174A>C (인트론 28) 및 이것의 일배체형 BL3_ht1 는 골절 위험도와 가장 유력하게 관련성을 가졌다 (p = 0.003-0.005). +159174A>C 의 마이너 대립유전자 (C) 및 이것의 메이져 일배체형 BL3_ht1 (C-C-T, 빈도 = 0.457)은 공동우성 (p = 0.005, OR = 0.65, 95% CI = 0.48-0.88) 및 우성 (p = 0.003, OR = 0.53, 95% CI = 0.35-0.80) 모델에서 골절 위험도에 대해 높은 보호 효과를 가졌다. 일배체형 BL3_ht1 (C-C-T)의 빈도는 정상의 대조군에서 0.465, 골절 환자에서 0.359를 나타냈다. 그러나, 마이너 대립유전자, (T) +164104C>T, 는 공동 우성 모델에서 골절 위험도에 민감하였다 (p = 0.03, OR = 1.52, 95% CI = 0.94-1.82).

상기한 바와 같이, 본 발명은 ITGA1 유전자 다형성을 골다공증의 유전적 소인에 대한 유용한 마커로 사용하는 방법을 제공한다. 상기 방법에 의해 피검자에서 상기 다형성을 검출함으로써 상기 피검자의 골다공증 또는 이와 관련된 골절에 대한 위험성에 대한 감수성을 예측할 수 있다.

이상에서는 본 발명의 바람직한 실시예를 참조하여 설명하였지만, 본 기술분야의 숙련된 당업자라면 하기의 특허청구범위에 기재된 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 및 변경시킬 수 있음 을 이해할 수 있을 것이다.

SEQUENCE LISTING <110> Korea Center for Disease Control and Prevention <120> Association of ITGA1 gene polymorphisms with bone mineral density and fracture risk <130> IPM-30957 <160> 95 <170> PatentIn version 3.2 <210> 1 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_01 <400> 1 cgggagaacg agatttttaa t 21 <210> 2 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_01 <400> 2 tgtgtgtggg ctattttgtt t 21 <210> 3 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_02 <400> 3 cacattccat ttccaaggag g 21 <210> 4 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_02 <400> 4 cgtcgaattc ctctaaatgc g 21 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_03 <400> 5 gtctgggatg tgaaaagcgt 20 <210> 6 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_03 <400> 6 cctgcctttt cttgttctgc 20 <210> 7 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_04 <400> 7 tggctgggtc aaatggtatt 20 <210> 8 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_04 <400> 8 catctcattt gcctccgaat 20 <210> 9 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_05 <400> 9 gcaagaggta ggctctctgc t 21 <210> 10 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_05 <400> 10 cgcccagccc aaaatct 17 <210> 11 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_06 <400> 11 catcaattcc caatgtcaca gaa 23 <210> 12 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_06 <400> 12 caattggtgt gggataaaat tca 23 <210> 13 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_07 <400> 13 gaatgagtct ctttgaagaa agaagta 27 <210> 14 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_07 <400> 14 tcagaaataa gaacaggaaa tgga 24 <210> 15 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_08 <400> 15 cgaacagtca cagaatggct a 21 <210> 16 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_08 <400> 16 gcgccttaac acctcttatc t 21 <210> 17 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_09 <400> 17 ttgaatgatg ggcattgat 19 <210> 18 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_09 <400> 18 ccttcctttc ctcctcttct t 21 <210> 19 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_10 <400> 19 cacagacata caaaattgcc c 21 <210> 20 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_10 <400> 20 aaaaacccaa accagaggta g 21 <210> 21 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_11 <400> 21 tggctgaaaa tgccctaa 18 <210> 22 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_11 <400> 22 ggaccattat gccttttctt t 21 <210> 23 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_12 <400> 23 tgccttgatt tccttttctg t 21 <210> 24 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_12 <400> 24 ggagaagtcg aggtttcctt t 21 <210> 25 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_13 <400> 25 ccaaaacaaa ttcttacgtg c 21 <210> 26 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_13 <400> 26 gcccgaattt catcttctaa t 21 <210> 27 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_14 <400> 27 ttcagggagc atcaattttt a 21 <210> 28 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_14 <400> 28 tatccgattt aactgctgag g 21 <210> 29 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_15 <400> 29 ccctaacttt actctcagat aggca 25 <210> 30 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_15 <400> 30 tcccaataag gtcaggagga 20 <210> 31 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_16 <400> 31 cagcaatatc ctctgggaac a 21 <210> 32 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_16 <400> 32 gatgcctcta ggcttgacca 20 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_17 <400> 33 ccatgcactc actttgcact 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_17 <400> 34 ctgacctgat gcacctgaga 20 <210> 35 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_18 <400> 35 cagtgtggat atgctgaaca a 21 <210> 36 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_18 <400> 36 gacagacaag gcccacag 18 <210> 37 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_19 <400> 37 gaagcaaaag cctgatgaga t 21 <210> 38 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_19 <400> 38 gcaacccctt gttaccttta g 21 <210> 39 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_20 <400> 39 ccttaagatt tttgcaggga a 21 <210> 40 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_20 <400> 40 cgtctgttaa ctgttttggc t 21 <210> 41 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_21 <400> 41 ctttgtcttt caggcaccca c 21 <210> 42 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_21 <400> 42 ctcacagttc tgagggttgg g 21 <210> 43 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_22 <400> 43 tgaggggaaa cattcacatt a 21 <210> 44 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_22 <400> 44 gcctttgctg ttgttagtct g 21 <210> 45 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_23 <400> 45 ccttcttcac cccaattaaa a 21 <210> 46 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_23 <400> 46 tggtttatga atggtggaag a 21 <210> 47 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_24 <400> 47 ggggtcaaat aagcatcagt g 21 <210> 48 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_24 <400> 48 caatgcatgt gaaaggtaac a 21 <210> 49 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_25 <400> 49 gccaattctc tgtacagcac c 21 <210> 50 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_25 <400> 50 gacagaggca gagataggag c 21 <210> 51 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_26 <400> 51 ggtgcataac aacctttccc a 21 <210> 52 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_26 <400> 52 tccagagggg accttggtaa t 21 <210> 53 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_27 <400> 53 tttcagtggc aaatgaggga g 21 <210> 54 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_27 <400> 54 ttgcggctgc tcttcagata 20 <210> 55 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_28 <400> 55 aattcactcc tccccttgag c 21 <210> 56 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_28 <400> 56 agacagtttt cattgttctc tgttt 25 <210> 57 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_29 <400> 57 gcccagcatt gccaatatac 20 <210> 58 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_29 <400> 58 actttccaat caccttgggc 20 <210> 59 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_30 <400> 59 tcagcactcg taaatgcca 19 <210> 60 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_30 <400> 60 gcaacacacc taaaaagcag t 21 <210> 61 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for ITGA1_31 <400> 61 ccaagctgtg agagtgtgtt t 21 <210> 62 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for ITGA1_31 <400> 62 gcaagaggac accaaacctc t 21 <210> 63 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +73187C>T(C92C) <400> 63 tccagttggg agaggtgaat cat 23 <210> 64 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +73187C>T(C92C) <400> 64 cacctggcct aaaaccagat ttttt 25 <210> 65 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> VIC probe for +73187C>T(C92C) <400> 65 caactttacg caaggta 17 <210> 66 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> FAM probe for +73187C>T(C92C) <400> 66 ccaactttac acaaggta 18 <210> 67 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +76969T>G <400> 67 gactgctatt tttggaattg atattagtgt aaataacttt a 41 <210> 68 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +76969T>G <400> 68 gagcatatct caaatgaagt tacttctttc ttc 33 <210> 69 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> VIC probe for +76969T>G <400> 69 aagctgtcat gctgctta 18 <210> 70 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> FAM probe for +76969T>G <400> 70 ctgtcatgcg gctta 15 <210> 71 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +109100C>T(A364A) <400> 71 gtagtgcatg aaaaggcatt gttacttat 29 <210> 72 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +109100C>T(A364A) <400> 72 agccagtctg agacatttcc atttc 25 <210> 73 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> VIC probe for +109100C>T(A364A) <400> 73 agctgtggct ataac 15 <210> 74 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> FAM probe for +109100C>T(A364A) <400> 74 tcagctgtag ctataac 17 <210> 75 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +110140A>G <400> 75 gcttatgttt ctataggctt gcaacca 27 <210> 76 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +110140A>G <400> 76 ctttgcatgg gttctggaaa atacc 25 <210> 77 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> VIC probe for +110140A>G <400> 77 caggattatt tcaacaagtt 20 <210> 78 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> FAM probe for +110140A>G <400> 78 caggattatt tcaacgagtt 20 <210> 79 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +130991T>C <400> 79 gaaagactga tattgcagag aaccctaa 28 <210> 80 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +130991T>C <400> 80 gaaactaggg tcacctcaat ggaa 24 <210> 81 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> VIC probe for +130991T>C <400> 81 aaaggatctc agaaatg 17 <210> 82 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> FAM probe for +130991T>C <400> 82 aggatctcgg aaatg 15 <210> 83 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +159174A>C <400> 83 tcaatcatca acagcaaact ggagaa 26 <210> 84 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +159174A>C <400> 84 tcatttcaac gtttgtttca ttgctgta 28 <210> 85 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> VIC probe for +159174A>C <400> 85 ataagctctg atatattcag 20 <210> 86 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> FAM probe for +159174A>C <400> 86 ataagctctg atctattcag 20 <210> 87 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +164104T>C <400> 87 tgtgttttct caacagattg gattc 25 <210> 88 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +164104T>C <400> 88 gaggcaaacc tgaggataga ttattg 26 <210> 89 <211> 35 <212> DNA <213> Artificial Sequence <220> <223> Extension primer for +164104T>C <400> 89 cactgaaaaa gaaaatggag aaatgaaata tttta 35 <210> 90 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Forward primer for +165697C>T <400> 90 gcatctaaga tcctgaaggc caaag 25 <210> 91 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Reverse primer for +165697C>T <400> 91 tttcttccag ctactgatgg cttt 24 <210> 92 <211> 13 <212> DNA <213> Artificial Sequence <220> <223> VIC probe for +165697C>T <400> 92 cacaggcgca ttc 13 <210> 93 <211> 13 <212> DNA <213> Artificial Sequence <220> <223> FAM probe for +165697C>T <400> 93 cacaggcaca ttc 13 <210> 94 <211> 165350 <212> DNA <213> Homo sapiens <400> 94 ggtcctgccc tgcgaaccag cgcggccccc tggcgctgag gctgctccgg ccatggcccc 60 tcggccccgc gcccgcccag gggtcgctgt cgcctgctgc tggctcctca ctggtgagcg 120 actcgctttt ctctgagcat ctcctgctcg cgggcttggg gcttggagcg gggagggagg 180 tcctcagagc catgggccag ataggaagag agagcgccca tccactttcg ggcattccag 240 gtactcaggc caggctacgg ggcaggcagg agtttcgcgt tctggttttg atatgaatta 300 gttttcgtgt ctctccaaag tccttcaccc taggagtagg agtgaggcag cactgaaaac 360 cttagaaggt agaattcact tttaaaatta aagttgtttt tacaatacac attgtatatt 420 aggactttgc tgaatatttc ctcccctcca ccctttttta tggcatggga tgggagggtg 480 atgcttatag ggcgcctgat acatatgcaa aattcctacc ctcgggttgt tccagagtgg 540 acattattga attttcttgc tgtctactat ttaggctttt ttcccatgca gaacaagaaa 600 aggcagggat gcaagacgaa actgccactt gttccaaaat gatgtttcta tgtcagcacc 660 caagaggagg gatattttga aacgtagaaa ggaatggtga acattttctc tgtaaatatc 720 acagggcagt ctacttttaa gatgcaaaat atagtattgt tatttgtaca taaatgtgta 780 tttttaagga ggggacttaa aaacatagtg gaaatgcaaa gttgtatcca atttagaaaa 840 agcttgaaat atagcatttt gtaagatttt cccaataatg aactcatggt cagatctttt 900 ttaccagtta ctgattgggg tgggggaaag ttgaaatggt gaaaaatgga agaaggtggg 960 gggaaagtgt atcgatagaa tctctgtgtg aaagaaaatc accttattaa tgggttaatt 1020 aacagctggc tttaacatat cattgatatt caattgttca gtgtttttac tgctggcatg 1080 gttattagta ctagttaatt tagcattttt accactaaaa acagggtaga gccagctagt 1140 ttagacctgc cttagatggc caagcattgt taagttttat gaagatgatt tagaagttga 1200 ttatcagcaa gcagagcttt tttcagaagg gaggtaatgt aaagagagtt aataattagc 1260 tactggcttt tcatccaaac atttcccact actcaggaaa tgtccaataa tccaaacagt 1320 ggtaactgct gaacagcatt atagccggtg agtggtttaa cttaccagct actgccacta 1380 ctttttacac atatttgacc tatgattctt ctccaactca aattttttta gattgtattt 1440 tgttgttttt gtgcaaaatc tgaatacagt agtttactat ccaagttgta ctttttcatt 1500 ctaccaaata agcagtctct agagtagaaa tgatgaaatg aggtttgcgt atcctctaaa 1560 aagacaagag tgaaacttga agtaacagag aagtttaaca agttacaatt tcatatatat 1620 gttggtgaaa tatacattgg tgaatccagg aagagactta aaatatttag aaaccttgtg 1680 tgcactatat ttatgcccat ttcgcaacac atgagggatc tgaaattgga ctgctttccc 1740 atcagtcatt atattctgta ggctcttctt tagcaatctc tttcagattt ggaaacttct 1800 catcaattca gagtccgttt gtaacctggg gactcatcac catacttatc catgcacact 1860 actgtagagc ttatctttct gtcttcaatt tgaacccaac ttccagtcta ccctcctaat 1920 acatcatttt tactatatct gtttttagtc aaaaatcttt ggtggttctt tgttgccttt 1980 aagataaaat ccaaaattct caactgactg ccctaatcca acaccctctc tctatctcct 2040 actactccta tgtcagtttc ttattgctgt tgtaacaact tgccatagat caccagctta 2100 aaacaacata aatttactat tgtacagttc tgtaggtcag aagtatcact gggctagaat 2160 caagatgtca ccagggctgc atttcttctg gaggttctag gggaaaatca gtttccctgt 2220 tttcaccagc ctctggccac cacctgcatt cttggcctgt ggcccctttc tccatcttca 2280 accgagcagg gtagaatctt cagatcttcc cccatgactc tgctttatca tcacatctcc 2340 ttctcagact ctgaccctac taccttccta aggatccttg taattacaat gtgcctacca 2400 gaataatctc ctcatctcaa gatctttaat ttaattacat cttccaagtc ccttttacca 2460 tctaagataa catattcaca ggttccaggc attaggtcat ggatatcttt gggagaccat 2520 tattctgcct accacaaccc ataagcataa actgtccatt atagccaatc acttttcttt 2580 actttctcca taatcctcat gttcattttg ccactgaaga tatgaccttg ttttatacat 2640 cgagaaaaga attccacctt tccatcctac caccctctga catctaaata aactctctac 2700 agccttccaa actgggttta catcagaaca acaagccacc agcatcccaa taaacttcct 2760 atttgattta gactgtctta tattagctcc ttacaacgtt tactaaaatg attcatcaaa 2820 aagatgtcct tatgtccaaa ggattgttat tttatgtatg tcaaagtctc agcataaact 2880 gatgtcacat ataaaggatt taactgaaga cagtttcata aagtgacagt ttagagaggc 2940 cttaaaggaa caagaaaaga gggtggagca tctagcgcaa gcaacagtag ggaaaaaaga 3000 acctgaagca aggtgagaag aaaaaccatg accattccta ggcctgagga ggtggcagtg 3060 ttagtttgat tatgaactct agttatggga gggtggccat tagactggag ttgtggtcat 3120 aaaaaggaat gcagctagtg acaaaattga agcccagcag agaaggagta aggaaaataa 3180 atatacctcc tttcctccca ccctctgatg tcttgctcag ccttcccatt ggccatcccc 3240 aaatggcaag atccaacctt ccagagaaca aagggcaaga caatcaataa cagaatagct 3300 agcacaactt aaccccgaaa tgtattatgt gcaaggcact gtgccaaggg ctttgcatgt 3360 attatttcat tttaatctaa aaaattaagt ttactaattg atcacaagca gtcacagatt 3420 tctttgttct tttttcactc cctcagcttg ttgattagcc ttgaaaaaaa gaaaagaaaa 3480 aattaaaact ttataactat tatcaatatt ttagagatga ggaaatcaaa atatagtatt 3540 aagaagttaa tttcatttgt ccaaagttga agaactaatg acaaatctac tcaattcata 3600 tctctgacct caaattaaat gctctaaaat aatatgctat attggctgcc taaagataag 3660 ttcattctct cttgctcact cctctaaatg tgaaatccaa acatagttgt ctaaaatact 3720 tggataaaga cctaattaat gatacaagtc aatcttttat ttccatgatt tttaggtgta 3780 cagcattaag tgtaactcaa gtaagactac tatttctcgt tattaagaat ataaatatag 3840 aattagccct aattaaacta tatgtctctc ttccctagaa acattttggt tggcctagaa 3900 gcaagggtct tcttttcaca ggcaagattt cctattcaaa atgaaatcca gtgaggagat 3960 gggagatggc tgaatatggg gaggaagtca gccacttatt caaaacaaag aatgactccc 4020 aatggcagac aatgtattgt caggaattgc tgaagatggt gaaaattgtc ttactcattg 4080 tgatgtttgt aaaggcagca atgaattcac gggatttttg tttgtttagt aaacaggcaa 4140 tgagagtaac catgagacac atatatatgc tatactagtt taactatttc tcttccctcc 4200 tgtcataaca cttacccagc tattttgaag catgagctct tgggccacag cttatcactg 4260 atgttctgac ttcagtagat agatgctcct ctaacatgtt cctccacttc caacccaata 4320 aacttcccac tagatttaga acttgctgaa tttccacatc ttaacatatt ttagtagaat 4380 aaagtagctc atgtttaaaa tatatttaga aaagttgggg actaaaatgc tattctttac 4440 ctacacttct cttctgttgt gtgaaataca aaatagtgta ctcaaattca tgttaagaaa 4500 ctgagatgaa agatattttg aaactgttgc cacagtgcta aagtcagaat agattgccta 4560 ttcagagcag tctgtgactg gagaattgta ttcgccctca aagcaagtac agtagagtat 4620 caagagatgc aaatgactgc atatatttct atcttcaaga ttattgagct tctttcagct 4680 cctttattat gccagctact ctaaagtctc cttggggact ttgcataagt agttactccc 4740 actgctactg atctcaatcc ctgaataaac gtcatttcca agagataccc tgaagtagat 4800 tggaccctac cttaggacat gtgtatccca gcacctttgc ttctattata taatgcacca 4860 cggtattata attaactatc taattgcctg tctttccagc ttgctgtatg ctctgtgagg 4920 gtaggatctt taaccataac acctagaaat aataggcact ttttaattga atgaatcgca 4980 aaagaattga ctattgacaa actcagaaaa tacttaaggg atcagattgt ccctttatta 5040 tatacctctg ccttatttta ttatacctct gcctgaaata tttctgtcta tccaaattta 5100 taaataatgg aatggaagac accatcagtt gaaagatgca ccattatttt atgtaccact 5160 aaaaaagaca agccactccc aatccaatta taattgctag attgttagat agttcctagt 5220 ttcagagatg tcaaaattgg gaaaatgtgc gtctgaaaat tacaatcaat aatatacagt 5280 gtatggtact ttttaccatg gtacttttct atttgtttgg acacttaaaa attgtgtcat 5340 aagattttga agaggctagt atgtgaaccc catctagata cagagatata acattgttcc 5400 tctcagttct cttcaagtgc caagtttata tctgatttag gggataattg ctcctctggc 5460 accaacagcc tcaccagatc ccaaaaacag agctccctcc aaatgctcta tctttagaag 5520 agagcttcag gagaaaggtg acaataaagt aatcatataa tgttccagtt gcacaggatt 5580 aatgactcta gctttggcaa actcttaact ttttgtcatg ttggtggtaa gctccagggt 5640 tgtgtatata ggaagaagac taattttaat caaaactttc ctatgattta aaaggaagat 5700 aaaaaagtca actaagtttt aaaaggaaat taaaatgcat atgctggttg gtgttaggaa 5760 ttcactttat gtgttaaaaa aaatcaattt tatccaaaca ggagatccct attaacaaga 5820 taagtaagag atctgaaatg agaaatcatt gtaattcaaa tatgcaaagg agtggataca 5880 catactcttt ttgtatgaat tatatgagat ctcctaaaat aaatgcaaat tcttaaattt 5940 aaatatagca cctaagtcac tttaaaacat caatagttaa gatggtttat atattttgtt 6000 acaaatcata tatccttact acaaattaaa tgtactttca aaattatttt attaattaga 6060 cttttatttt accaaatact aaagtctaga aatacatggg tactggccaa tccttaaaaa 6120 tatctgtgta acacatttta cttataatat ttttggtgaa atgatcttat gccgtataag 6180 aatacatgca aatagaaata cacacacaca cacacacaca cacacacaca cacacttctg 6240 ttcataggat tttgtttatt tggtaggagg ttttgtatta ttttgtgaca actgcaagta 6300 agcactttcc atcatgagaa atttagatag tgagtgagta caagttcctt aaaaaaaaaa 6360 acaaataaaa caaacaaaaa aaaccacttt cccttttacc cttttgtcta tattagctaa 6420 ctaatcctcc cagtcatcca cttagctttg ctggtggagg tcacatggga acctttgcac 6480 aatctgaggt ttgcacattc tctctaaata aacaattgcg tttatcacta gatattcata 6540 attggagctc tggcttctta ttttgtaaag ttcactttcc aaaccatgta taataaaact 6600 aattgccatt atgtgttatt ctaaaatatt ttaagaactt ttcctgggga agatgtattt 6660 taaattacca ttttcttacc taagcacggc tatctcaaat attgaaatag gcttatacaa 6720 acttacctta agagtaacct tctttttaag tttttagtaa cattataaaa cagaatgtga 6780 tttcctaatt ttagaatgtc agttacagac aagttaaaaa ctctgaatta aagaaaaatt 6840 aataaccatt aatttttgca tactaaaaat atgagtatgt gccacttgtt atgctgtgtt 6900 ccaggagaac aaagacaaat aaaaggtagt aagtctctgc ctttactggt ggaagaggta 6960 gtagacatgg aaagacacaa tggtgggaga ggctcccaag gtgctttata aggaataaca 7020 aaaagattag gtttgtgttg caggaaagta agccttccaa aataaaatac aagatgaaaa 7080 caagaaaatt tatacagccc cgactgttta agggtcacaa gctaagcaga gggtattaaa 7140 acaagatttc catctttcag gagcccataa ttccatttca tgtcatacaa accatttctt 7200 ttatattatt ataataggaa agatagtaat tcaactcacc aatgaggtcc atgaaccatt 7260 ttattcagta gagctgaata acataaataa cataaataaa tgtaccccaa agattatcca 7320 tcagtcaact ctaccaaacc agttattttt ccaaggctga ataattatga tcatgttaaa 7380 atgagctctt gtcccttgtt ttgtctgatc cagttttcta gcttcaagcc aggcattttt 7440 agagctctat aatttattaa tatcaagtat cataatatca ctaggacctc ataaggatgg 7500 tcaaatgaga gagcaggaca aataatctta tttatcattt agaatgaaaa ataattagct 7560 ttattgcggt ctgggactta tttcaagttg gtagaatcca tccaggaaag accatatttg 7620 aggtctgcca attcttggtc cacaaacaag aaactttgaa tcagtctttc acctctgaaa 7680 tgggtcttag aaaaatcaga tttgaaagat agcacgcaaa attgaaaaca aatatgttag 7740 gatgagatta taggtgttgt ttaaacactt aaaaaatatt actgcagcat aatttttagt 7800 tagaaattta attattgaat tcaattccct caattcttca gtgaaataaa ttgggttcca 7860 gagagactga gtactgccaa aagttacagt aaaaacaatt gaagagtaag agctacaatc 7920 caggatgctt gacttctagc ccagttctct tcttgagaca ctggaagtgt ctcaagagca 7980 acaaattaaa aacttttgga ggtaacaata cttttttccc cttctggaga gattaatata 8040 aataagacat tgtagggaaa atagatataa ttaaagttac tgatataaag atttatactg 8100 atataaagtt actgatataa agttttctat tttaaacagc caatacataa gtataaaatt 8160 agtatttaaa gcaaaagagc taaaagccct ggtatttttc tcaatacttt gctcatttgg 8220 aaaaaaatga aaataaatat ataactacag cagtttctga actaccatta ttaagtgaaa 8280 tacagtcaat aacaatataa gtaagtgcct taagaaatgt cttgaaatgt ctgtaataat 8340 gttaaaatag ctgccatact ttacatttga ctcacctagc ttatcattaa tatatgagtg 8400 cctactatgt gcaaaggacc tttaaaagga caaaggagta taaagataaa tccttccaga 8460 gttcaacaaa aaagatacat gtttaaatta acatggattc aagtttacat ggtttcaagt 8520 ttgagataac atttaagctg gactttaaag ataggcagca ctaaaggaag cagggatgaa 8580 aggaagtgac attttaaaca gagaagttag tatgagttaa ggtagcaaac gagaaagttc 8640 ctagcatatg tagggaacaa aggttacttt caaggtggaa tatagggtgc cctgagggga 8700 aaagtgggaa gtaaatttgt aaggccagtg caaattggga ttgtagacgt taattcatag 8760 ggaatgggaa tccaaaatga atcaaaataa aaatataatg attggtctag aaatactaag 8820 ccataaacaa aatctgggtg aaaacatcta atagtcaact acaggcttaa attactaagg 8880 aaaaaaaaaa gttcccaact attgcagttg tttcacatac aacagtaatt ctatgaaaga 8940 ttttatagta tactgaatta tggaggcaca ctgatatttt ttaaaatggc ccaaagtggt 9000 ttgcctcata acttaaaaaa aaattttttt aaccatggat ttaagagtca ataagggttt 9060 ttcacaggtt tctaatgtac agataaatat atgtatattt ttctaaagta gaacattaga 9120 tctttctcta agagtatgat gatgacctag gctggacaga aggaaaaaaa aaaactatgt 9180 agaagagaaa agtataataa ttttaagagg tgataaaaga gcaggaaagg gactagtgcc 9240 tttcaaatcc tctaggttgg ttcccaagct gtgagttttt gtttagctgg taaaggtgac 9300 agttgagggg aagtgacagt ggataatagc acataatttg cagtgaagga gatgattaca 9360 aacattcata atataggatg gtggtagtag aaagagaggg tatggagtta tgcaggcctg 9420 aatttcaatg ctagtcatgt gatcttgaaa acatttctta acttccccat agttgatttt 9480 cttctataaa attaggataa caaatattta ccttacaggg gagaattaga gcataggaaa 9540 gaacttgata aacattcaat acgtgatagc tcttcaataa aaaccttttg ttaagatccc 9600 actgtgtgct taccactgtg attctgtggc ttttaatctt tggcagacta tgggaaagat 9660 aaattgtact tagaaagatg atcaaggagc acttcaaagc cccagttcaa aattatctcc 9720 tcattctctc tctctttctc tctcacaaat acacacacaa gcacactttc accctaccaa 9780 ttaggaattt taagttaaca agatactttt tttaaaatac agtgtccttt ggataggcaa 9840 atcaccttca cacttgagtg tgattagttc tttgcttagt gaaaagttgc tgggttctcc 9900 tggaattgga agaaggcaat gtgaattagg aacttcttga gggtactcag tatgatagga 9960 aggtgggaag aaggaggaag taaggggaga catagagagc gagaaacaaa gagaaaagag 10020 gccacaaata ttaataagta gtggttctta tttggacttt ccccttggag gggacctttc 10080 cgtcccctga taatctctta ggaagataat gacacttaag tttaaattgt gaagcctgtc 10140 agttgagaaa aatgttgaga caagtctcaa tcattttagg acgtttattt gccaaaatta 10200 aggacgtgcg cggggaagac aggtctatgc ctttctggga agatgatttt gagggctcca 10260 aatttaaagg ggaaagggtg ggatactgag aaatacagtt ttcatgtgag agggtagcag 10320 ggggaaaata gtcattcatg cctctgtctg gcttagtcaa tctgaatctg catttttacg 10380 taagataaca tagacaaatg gggcagggga acaatcagat atgcatttgt gtcaggaggg 10440 cagaggggtg actgtacctg aaaacagaag ctatctattt acattgccat ggtaaatttt 10500 catagaaaca ctttatggta aagatcttgg cgctcactga gaatttcctt gtgggcaaaa 10560 tatgagcgag gtgtgtagct tttcatctgg tagccatctc atttaaaaac caagaggcaa 10620 ggcagttttg cgtgacccag ttcccagctt aacttttccc tttggcttaa tgagtttggg 10680 gatccgagat ttattttcct tccacacgcc tatgccaaac tcagattcct tcctttcatc 10740 cctgtttcat ctgttcaggc tggttagttc ccctttccaa tccacacaga gaaagacaga 10800 aaagacagtg agaagctatg tgtgcaggac ttctctgccc tccactccat ctaagctctc 10860 aagaaacttt tagattcttt tgttttttct attcatcggt ctcttaaaga ggcaatccca 10920 cttctccatt tccacttcct aataaagaat gctaagtaac ttaaggattt tctttaaatt 10980 atgtagctat tcaatcaggg tcagtcctag ttaatagttt ttccccactt cccatagcct 11040 cggcttttag cttagctttg gcagtgaaga tctggcccta agctcttgcg acccaacccc 11100 caacctaaac atttcacagg ctactgggct gcggaaagct gaggctgcca actttggagc 11160 ctaggattcc caggacatca ggtcaagcaa ctgagaggtc cacccagggg taaattccac 11220 acatagtttc ttctctcttg ggaccagcgc tttaacatct gggtgaatca gatcgtgcag 11280 acacggtaac taggcgcaga aaacagctgg acacgttgct gggagcccag acagaacgtg 11340 accagtagtt ctcagaaacc gcttctaaat accagctcca acaggcttgt agcgtccgag 11400 tgcggataag gcaagagcaa aaacgagcat agtttgggcc gttggggcca aatctgcact 11460 tctgagagct acttttactg ctaagctttg aaattggatt tacccagagg gaagcgttgc 11520 agtggcagcc gcaggcaggt aaaactagta tttgcactca cacactcccc ggattcttca 11580 cagacaggga tggaagagaa aacttaggaa gttgaagttt ggcattaaaa taaaggactc 11640 gccaccactc tgtgcacctt cttgagggag ttcattcgtc cggagcgcct cacagcttag 11700 tgcgcctgcg cacgcgcgaa ctgcggcccc gcctctcctt tggggacggg agacgtgcgt 11760 cgggtcgcgg gacgggggct gcgcatgcgc cttcatttcg tcagcccgct gttgcgtgct 11820 gccagcggga actgtgtagg ggtagatttt cgctgcagtg ttccccgagc ctgttagacg 11880 cagcgcgccg ggagactgag agaggaaagg atagaggaag tgctgcccta ggctgcatga 11940 gtcgaagcaa gcgtgtttcc ttcccgccag gcaagtgccc ttagaaaccg ggccccgccc 12000 ccttcctggc ctgcattccc atcccctctc ccggggcgga ggtgaggacc tccttggttc 12060 ctttggttct gtcagtgagc cccttccttg gccatgaagc tcgtgaggaa gaacatcgag 12120 aaggacaatg cgggccaggt gaccctggtc cccgaggagc ctgaggacat gtggcacact 12180 tacaacctcg tgcaggtggg cgacagcctg cgcgcctcca ccatccgcaa ggtacagaca 12240 gagtcctcca cgggcagcgt gggcagcaac cgggtccgca ctaccctcac tctctgcgtg 12300 gaggccatcg acttcgactc tcaagcctgc cagctgcggg ttaaggggac caacatccaa 12360 gagaatgagt atgtcaagat gggggcttac cacaccatcg agctggagcc caaccgccag 12420 ttcaccctgg ccaagaagca gtgggatagt gtggtactgg agcgcatcga gcaggcctgt 12480 gacccagcct ggagcgctga tgtggcggct gtggtcatgc aggaaggcct cgcccatatc 12540 tgcttagtca ctcccagcat gaccctcact cgggccaagg tggaggtgaa catccctagg 12600 aaaaggaaag gcaattgctc tcagcatgac cgggccttgg agcggttcta tgaacaggtg 12660 gtccaggcta tccagcgcca catacacttt gatgttgtaa agtgcatcct ggtggccagc 12720 ccaggatttg tgagggagca gttctgcgac tacctgtttc aacaagcagt gaagaccgac 12780 aacaaactgc tcctggaaaa ccggtccaaa tttcttcagg taaaacaatc ttacccaggg 12840 ataattaaga atgggcagag ggattggtat aaactactcc taaagtttta gaactgggaa 12900 aaataagaag agaaagtctt tacttagctg ggattttcat gagataatga aataaaaaga 12960 gaatgttaaa tgtctagcaa atttatggag taaacttcgc tgaaacatat gaagccttac 13020 tagcgctttt ggctttaagc ctttgtgagc tgattaatgg gtgttctagg agattatttt 13080 gcctaacttt tgtaattgtg attctaggta catgcctcct ccggacacaa gtactccctg 13140 aaagaggccc tttgtgaccc tactgtggct agccgccttt cagacactaa agctgctggg 13200 gaagtcaaag ccttggatga cttctataaa atgttacagc atgaaccgga tcgagctttc 13260 tatggactca agcaggtgga gaaggccaat gaagccatgg caattgacac attgctcatc 13320 agcgatgagc tcttcaggca tcaggatgta gccacacgga gccggtatgt gaggctggtg 13380 gacagtgtga aagagaatgc aggcaccgtt aggatattct ctagtcttca cgtttctggg 13440 gaacagctca gccagttgac tggggtagct gccattctcc gcttccctgt tcccgaactt 13500 tctgaccaag agggtgattc cagttctgaa gaggattaat gattgaaact taaaattgag 13560 acaatcttgt gtttcctaaa ctgttacagt acatttctca gcatccttgt gacagaaagc 13620 tgcaagaatg gcactttttg attcatacag ggatttctta tgtctttggc tacactagat 13680 attttgtgat tggcaagaca tgtatttaaa caataaacta aaaggaaata atctccacgt 13740 actaccatct tgattaaatt gtgtaatttt ttataggaat tatgagttat ctgtagtact 13800 tggaaacaga aaatgtgtgt atttaaagac gatgcctatg cagtatattg tttgggatag 13860 attgcaaaat ttcacactgc atgctttgaa acagttttcc ttagaaaaag cttttgctat 13920 cttatcctgt ttacattatt tctttatttt aattctgctt ggtgttcttg cattgcattt 13980 aatgatccct tttctcccca cctccacaca ctacattttt tttagattta aatagtttta 14040 ctattttaaa tgattgccgt acaattagta gacttgaaga caagttttaa atatttttct 14100 tcaaaggctt gttaaaccaa tcatgttaaa aggaaattct tggttttggt ttgttgttgt 14160 tagcattagt catatttgat ttagagggta acttaaatca gttattttta gctttttaga 14220 actttgatct gctagggatt gtcaaaataa tctccttgag gcatctttat ttttaaaatg 14280 agattaaagt atgtgatttg cttgttatgt ggctaattag tggcaaagct ggaagtcatt 14340 cccagtctgg actttagttc tttgcgccaa aacatgctat attatttatt tatttttttg 14400 cttgtcaaag ttatacttaa ttctgtttta tatttgtatg tggcattaat ttgggtttgc 14460 acatttttat tggactattt tagttgtgaa gaagcctgtt ctaaagttta agtcacatga 14520 ctagtatgtg gcagttgact taaactccaa tactctttac tatcattgac ttaaactctg 14580 atactcttta ctataattat ggaattgtgc aaatacctct gagtttaaaa tattattttt 14640 attatttttg gtgcacattc ctaaaagtta aggaaggagc ctcagtaatg gaattgcttc 14700 ttgacctttt gcaaacctca atttagcaaa ataattagga acgatctaat agtgatgata 14760 cagtttttaa ctgctggatc agcgacgcct atttcaagta gtgatactaa ctaaactttc 14820 gccggtcttt cctgtgtctg tgggccttcc tcctggtgtg acagacttgg ggatttcttg 14880 taaacttcct aactagtctg aaccttttta tttcttattg ggaactgaca cttccctata 14940 ctttaaaact cacatatgta tatttttgta catctatctc ctaattcaaa agtaattgag 15000 attgtcattt cattataatt ccgtgagtat ctttaaatta ctatcaaata tgttactaaa 15060 taatttaata agaatataga aatgaagcca ctgagatcct taaagttgaa acctgattgt 15120 tattatattt tcagtaagga tttggagatt tttggacatt tttactctca taatctatgc 15180 agtactgaaa tgaggtctaa taaatataac caatacatgt taggccatag gttcttaaat 15240 ttagctacct gttcacctca acttgagagc tcttaaaacc ctcagtgtcc aggttgcagc 15300 tcagactagt taaataacgt tttatcccta gaaatgtttt ttttaaagct acccagatga 15360 ttccaatagg cgtcaaggct aatagccact gattcaggcc ttgctattca aaagtatggt 15420 ccgtaaacca gcagcatccc tgagagcttg ttggaaacta gaattcaggg atcttttgta 15480 gacctactga gacaggcgct acctgtacca acatctctag atgattcctg tgcataataa 15540 aatctgataa acaaaggcaa taggttattc ttcctgtgct ggtaaatctc tggcaggggt 15600 ccccagtcag gaaaaagatt tgagtattaa ggtctttcaa aaaagttaac tggccatact 15660 caactgtcta taaaacctct ataaatttct gtttttatgt ctatgaatta ttaaataaaa 15720 tttaactcat ttttaagaaa ttacattttc tgttatcaag aatacaattc ttactagatc 15780 ataggtgaaa atgtcaataa tgataggagc aaattaaaaa ttcagataat tatttttgac 15840 ttttctagaa gacataatta tctctggaaa gcatatacag tagtctaatt ccaactgcta 15900 ctcattaagt attggatatg tgataaaaac tctatcgata actccaatgt accttctcta 15960 atgtactgta aatttccatt tcctatcatg tgcttgcaaa caaagatttc ctatgccact 16020 aaactcaata agtgagaagc ttgcacatta tttcattttg ctatagctac gatacatatc 16080 aaatgacagc tactcctggt ccctcatttg tatgttaaat tccttgttaa ttttatgaca 16140 agattgttga tcttggattt cactttcatt accgtcttag aaacaaattg gatttttctg 16200 ctcccagatg ccactagagt agctttgtaa agctcatttt tcttatcttt acttagtttc 16260 tgtctctaac tttagtttcc tttttcagct tccctgacta attctcttaa cctccaatta 16320 tctttaacag aagttactaa ttctgcaatt catatattct ggaactggaa ttatctttgt 16380 tcctaagcaa ccaagtatac atatgaaacg gtctgtacat taatgcctca taatagcagc 16440 tcttatttgg gaaagggtta tagtacattt aaaccatgtg gttttccaag caagttaaga 16500 ctggctattt gtgtttagtg tcagaatatg ttgaattaga agttgaagag tttctaaagt 16560 gattttaagg gcttgaggag agatgaaccc ttttgcttag agccagaact tagatatggg 16620 gtgtaaatat ttatattaca ctaatcatta agagtaatat atttaatttt atccattttt 16680 ttagtgcctt ttttgaacca atcactgggc tagatgtggg gaggacaaac atgtaagcaa 16740 atcactgtta gaagtaactt gtacaaagtg tgtaaaagga cacagtggtg aaaggggtga 16800 cttttaggag aaactttata gagcaaggac cagtaagttt acctaaaagg ggaagaagaa 16860 atatggagaa attaagtggg aagatgggga ggggaagtgt gctaatcacc taagaacctc 16920 cgtgctacaa gaaggagttt gggtttgacc attaggagaa acaattacaa agctgaagca 16980 gcatgctaaa ctgcatttca caaataccac tttggcagca tcaaggatcg attggaggag 17040 gcaagactgg aggcaggaag actggttaaa aaaatgcata ttaggaagat atgagagaaa 17100 aatgataatg gccttatcaa aggcagcaat aatgttcctt gcaataggaa tgaacagaag 17160 tcaacaggaa atattaagag atgggatcaa aaggacatga ctgcagattg ctgtttagag 17220 ttatggaaaa aagtagaatc caaaggtaaa tctcagattt cttgagtggt gggagagatg 17280 atgacacaaa atgtaacttt aaaaatggta attaaaaaaa aatgttttat gcagtggtgg 17340 ttaaatttac taaaagattt tttcaggatt cccatagtgc aggaattagc aagctatatc 17400 tcattcaggc caatcagtta ctgctagcgg accccatggc cttgtgctcc ccatcttaac 17460 atagtatctc tgatttgtct caccagacaa atcagagata cacttcccct tttattccgt 17520 gaggaaccac aagagtctga actgtggcat caattttgca gttggattta catctttctt 17580 aatgatttga aaataatttg tttcaaaaat tgattttgac cagcacacaa ttttgctggt 17640 atatcatgtt taagtaaatg aattctccag cagtgaagca caactaaagt gaagagctga 17700 agagcaactt aagaaagaac aattaattcc aataaagttg gtaaaatgct cagtaaaata 17760 attttcttcc aatggatgtc agcatattta aactttgtgg tgtgattcag tttatatact 17820 ctaagagatt cagtatttta gaaaagtgct cttcaagatt ttcctaatgt attatatgta 17880 tctctcatga attgaattga tttagaaatt tagtgtaaaa gtgttacaca cagccaacat 17940 gatttataaa ggatctagga tgcaattata atatttttgt gaatcaatta tgccttttta 18000 ggaaaagatt tagaagttaa aaatgcagct aatgaagctg ttagaaaata aaacctgtat 18060 tagtagtctt ggatttaaca aggagaacaa tcaggagttg ctaaatatgg tcatcaagta 18120 gtaaacttca cgtagaaata aaaaaattga ccaagttcag taaagagata tttatttagg 18180 ttaaaaatac cattcaaaaa cattgggaga aggtatttat taatggagat accttcttca 18240 gtggcgatga taaagtctca ttcattgttt ttctttatat agtaagaatt agtccttttt 18300 aggaagtgtg tgatatatat caccatctgt attctcatcc acatgttaca ctattatttc 18360 taaatttcca agaataatct gtaaaataac tattttgcag tatttaatat ctctattttc 18420 agtaacatgt tattatattg tgttgagata aataacactg attaataaat tggaatatta 18480 tgaatgtttt aatttaaatt gagaaatgaa tgagtttctg taaggacaaa cacctttgtg 18540 tgtagtatta tagttgcata caaatttgag gctacagtgt ttgcttttta caatgaatat 18600 tttaactcta taataattga cattgatatg ggaaggtctt aaattttcag atttcagtgc 18660 taaggatgat aacatttatg ataaattgtg gagacttgga tatcagtctt cttttaaatt 18720 tcctttcttt atttcctaaa attgcctaca ttaaaacccc attctttaga atgttagttc 18780 aatggaagtg cctgttttct ataatgtcag agatttaagg aatttaaagc ttatttctat 18840 ttgggtgcca catttgtttt caaaacaccc aatactgagg caagagcagt atttgccaag 18900 tagcaaattc aagagcaaaa tgttttggca gtcatattgc ctggctttgc ccagggttgg 18960 taccactgtc cccactccag gaatggacaa cctgttataa caaaagtaac tgtgtgctta 19020 ttaagtgtca ggtcttatgg taagtgcttt aaaatgcatt agtctttcaa gaacccagtc 19080 agaagggttt tgtcattact attttctgat gcaaaaaaaa tgaaattaaa gaagattaaa 19140 taatttatcc aaaataacag ttagtgggtg tgatgaggtg ctccctcagc tatcacccta 19200 aaaaatctaa gaatgccagt tcttctcagc tttcagtttg gagtaggcaa acatgtatct 19260 aaaaataaaa ataaattatt tgatgacact aaattttata taatcagcca aagtttatgc 19320 aatcattttt aatgttttta ttctattatt ttgtcatctt atgaaaaatc aggaactcaa 19380 ttctgtggtc ctctaatcta cctggatcat agtggagaat tagaaagcag agaaaatgtg 19440 gcaaatctat gtattaaagc aatcccctca agcactatcc agcattcatt tattgttatt 19500 tcacacctag tttcagcaag ctttttttgt tgcttaattt taaacctaca attaagtcat 19560 gcactattac aataaacttt tttttaatga ctcaccttaa gtagctagaa ctatgctacc 19620 cctgggtatg caaggatgaa ttaagacagt tttccctgcc tttaatctag aaattagata 19680 tcagcaggag atgaccacaa gtggccaagt tgacagaatt gacagcagtt aaaagtgaca 19740 gctgatagtg ggagtggatt ctgaaacact gtcaaaagaa aaaaagccta gagtattata 19800 gagtatttca ctgggacttg aggatgttac tgaggacaat accagtacct ggtattcaca 19860 ctgaggaaaa gattaaatta cattcagtgt attctgttaa agaagtcaaa taaatgtaat 19920 gtctttcaat gattttcatc caaaaatagt ggtactttaa aaaatcttta gctgtcatac 19980 ctagaatgac tgttccagat aaccagagtt ttactatgcc ttaatagtct cagtaataaa 20040 actcaaataa ttgttgaagg atgaattttt gttaaggaaa aaaatcccaa tagattttag 20100 ttgtacaatt tattcagaga taggaggtcc ttctgagttc aagtctacgt tccagaagtt 20160 ttatgtctgg aatttttcat caagtcctag tgtaaacatt gactagaact ttttgtttga 20220 caccattgtg aaaaattgct ctgtggatag aaaacatttt aatcttgtgt ttcagctcat 20280 ttgatctgat gaccataatt tatagtttat ttttcctccc caagtgtgtt gttgactatg 20340 gtataattct ttttttcttt ttctttcttt ctttcttttt tttttttttt ttttttgttt 20400 gatgagtttg aagaggaagc ttaaaataca tttcagtaca tggctctgaa tcacttaaaa 20460 tcataagagg ttaaagctgt aaggaacttt atatatcatc ggacctagtt ccttcatgtt 20520 acagatttaa gccagcccag agagggttgg taacttgctc aaacacaata ggagtttttc 20580 acagggtcca cattcctgtt tgatatatct gattccaatg tcacctactt tttgtcacct 20640 attcatattg agtcatttgg ggtagaggaa caaggaacaa tgcaggattc aaaaatgcct 20700 taaaccctcc ttatttatca aattatcatc ttgtggcaag gcagtttttc tctgagcagc 20760 attgctgaga ctcaaactca gttttgaagt cttgttcatt ccttggagga gtatttatat 20820 ttccctatag ggaactcttc ctgcctttct tcttctgaga accatttcat ttttctgaaa 20880 atcatgtact aagtacctac tatgtgacag ggactctaat agcccccagt gatcagaagt 20940 aaagaaagat cacagtctct tccttgcaaa aaaacacagt ctacaatggg gaacgaatgg 21000 taaagcagta gtaatagcag tgcaatctgg cacaggaaca tgggagctca gagggctaac 21060 tcagcctggc tttagtgagg aggtattccc agagtttaaa ctggcaagtt ccagaagccc 21120 acactgatct tccattagtt tctagagaga tcaggtgaag ggacctgaga ttattcctct 21180 tttaaggcct ctcaacttta cttttttttt tttttttttt ggagacaaga gtcttgctct 21240 ataccccagg ctggagtgca gtggcctgat cttggctcac tgcccctctg cctcctgggt 21300 tcaagcaatt ctcgtgcctc accctcccca gtagctgggg attacaggtg cgtgccacca 21360 cacccagcta attgtcatat ttttagtaga gacggggttt caccatgttg gccaggttgg 21420 tctcaaactc ctgacctcaa gtgatctgcc catcttgtcc tccccaagtg ggattacagg 21480 cgtgagtcac tgcacctggc ctcaacttca ctttggtaat atttttcttc tacagagtgg 21540 tctctgtaat ccctgatctc tctaaatgtt aaatatttac tgtggagtca acaaacctga 21600 gaggagacat catggagaag gagattccat tacctcctac cctcataaga aaatgaaaat 21660 caaatacaga ccagggacca tgactgaaag gactctgaaa gattgtggaa cctttgtata 21720 atagtatcca tgtttttgtt gtctcctctg catttcttac atgactaagc actgactggt 21780 taaaccagaa aaggaagctt agcttctttc gtttttagga cagcaaagat ggggatggtg 21840 acaggggagt ttgagacatt ctgtcccttt ccatagccat tcctggaaga aagaatgtcc 21900 aggattaact ggttggtggc acagccacct cagggaaagg gaaactgacc cctggggact 21960 gaagtcagga ataaagaagt gacaaggagc tagctggggc ctggggaagg ccctggggct 22020 ggacactaga aagacccacc ggggtctttt ctatttttat attcaacatt ttatctttcg 22080 ttgtaaaact caggaaaaca cctttaacaa acaaaaataa cttctctctt aagttgttca 22140 ttttactaaa tggccaacat ggattggata tggtagaagg aaagaacatt ttctgcagaa 22200 gggagaaaaa aaccacaatc tattttatga ggaggaatga actctgggaa tagttctctg 22260 accctttgtg tgtcagtgtg ttctcagcct gaactggaag aaaatgggat agcatgtgga 22320 atgtgggaaa gtgcgaagac tgatgcaaaa ttcactatct gcctcattaa atacactagt 22380 aggttttcaa gagaatgagt ctgttatcac cacagtaaat ttctcactct gggcctaact 22440 ccttatctaa aacttaatag agcttaataa gttcaaattt ttcctgtctt tctgggaatc 22500 attttcacct ttatctctga tcctgtactt tccctaggtc agagtaaaat ataatgggaa 22560 acgggcaagt aggtaggaaa tgtggagaag gtcaaggcct ttttataatg gttcattgta 22620 aatttaaaat tcttagatat gtatttcata cagattcaca tatgttcttc tggatgaatt 22680 agaaatttta attgtgagga tcaataaagt agcgcaacca gctttcacat ctgtatgaaa 22740 tttaggactt tgcaaaggat gttgcacacc aaaaattaca aaataattca acgattattt 22800 gctacagtta ccaaagatta taatattaac atttgcaaga acattgcatt tgtgaataac 22860 caagtatgat acaaggaaga aatcatccat gtcattctca gaggatatgg tgtaagaact 22920 ggcccatgac tcatgacacc aggccctgcc actaggttgt gtgacttgag gaaataattt 22980 catctttttg agagttggtt tcttcatctg cagaatgagc aaagaagggt ggctcttgac 23040 ttcataatct ctcttgcaga tatctgattc tacttggtgc agtaacaata attgcttgtt 23100 atttttgcga tcatgtcttt ccagtaaaat aaatctttag tgactctcag gtttaaaaag 23160 aatctttttt gcaccctatt ttaaaagctg ccagatttgg ggtttggctg actactaagg 23220 agagcagcct gctagaagga gcaaattcca gagctgaggg tcatttattt ggaatgcttt 23280 gccaaacact cccctatttt taaagttgtt gggggacttt aaacttgaat atagggtggt 23340 aggacaattg tttgaaccac tctgtaaata cgtgcatgaa aatcttgagg tttacaaata 23400 ttttttaata gtttgccaca tttcaatggc atgtcaagtt gcagggtcct gccacttttc 23460 ttcttgttat tttcctcttc tatcaacttt gctcactctc ccaaagaaat aggcaatgag 23520 aaaaaacagg tcttaatttt tactggaatg ctctttccat ttggctagag gtttctcaaa 23580 ccaggcggca ccaatcacct agggagtttt aaaatcatgg tgatgcctga gccctacctc 23640 aactaagtca gaatatttgg gaaaggagcc caggcatctg tacattttaa aagctcctca 23700 ggtgcttctt atctgcagcc aggttaaacc aggagtgtca tcactgagta ggactattag 23760 ctttaatgtg tcctgtgacc acaataccaa tcagctctct ggttaagaaa agagatgaac 23820 atagacattc tgaaaaggca actttataaa gttgagggga atgtatttct ttagctttaa 23880 tgcctcactg tgggatttgt ctatacattt atgtattttt aaattactat cataaattca 23940 caattagtac caaaaccgat caatttgtga atatttattg atgccattta catgcatatg 24000 tgttgctaaa tacaatggga gggggcctac agaaaggtag agaacccaga tcccacccac 24060 ttcttgaagc ttataatcat tttggggtgc aaggattgtg taaaacaaga cacaaaaatc 24120 acacatgtta cagaaattaa aagctaatat cactgagaac aggaagacat tacaattggc 24180 tagaatcacc tcaggagatg gtacttggat ctgggcaccc tttgaatgtt tttcacttat 24240 ccggtaggta aggacattag ctctggacta gaaaatcttg gatctcccac aggtgagctc 24300 tgtgaccttg agcaagtaat gttaccttta tgattctcaa acttagcttt gtgagcttca 24360 atttgtaaaa tggaaaaaat gataaaactg ctctcataga gttgcaagga ataaatgata 24420 tgatgtaagc aaaatatctg aaaattccta agagcgcaat ttaagttcat tttgttcctt 24480 cttatcgctt tttttttttt tttttttttt ttttttgcca aatacaccac ttgggcaaca 24540 gatcagccat ggaaatatga tgcagaagat ctgcctcatg cctgttccta acataaatct 24600 ctctctacca aagctgtctg tcagagattg tgttcaaacc agaacaagtg gacccactca 24660 gtccagagtt accctcaaca tgagacaggc tacccagctg gttctctgtc tttataatat 24720 ttttatttct ttaaatttga tgaaagaccc acttttgtga gttttacaca caaatgaaga 24780 ggagtacaga agagcacatt tcaattgtaa tgttcatgcc aggaatagta acctcttcaa 24840 ggataccact gagtgcacac agaatgctgg gaggtcctga ctctgcttat ggaaaccaca 24900 gaaactcatc cctgaaactg gttctatagc agccatgacc ctcattaaac ttccaatcaa 24960 gtaaaattaa tattagctat taggttagat gttaggtatt gtctttgcct ccatttaatc 25020 atcttacttc ctatggtacc tgttaattat gatttgaatc tccttaactg ctcagcctgg 25080 gtgtttcagc catatataag tcataaacag actacaatta tcttactatt tctcagttac 25140 ttgcaaacaa caggaaccaa gtctgataat acaagaaatg aagaaatttt ctggaagaag 25200 gcaaagaggc tcagatagga acaaagaggg gaggcacagt cagaaccctg ctatagaaat 25260 cacctgtgta aggcaatgca gctgatggaa tagccacccc cagacaacca tcaccaatac 25320 actggggctt ctgagagact caaccagagc ttctgagaat aatctctgag tgtgaaaatc 25380 agattggcta ttgaaaggtc acatgcccac attctatgaa ccaggagcag gataacggac 25440 tattctatat gcctacatct cctcctctca ttcacatctc ctatgtacct tccccaacca 25500 ggaggaattt gtggattcta ggtagccaaa acaaaagaaa atattcacta accattttaa 25560 agaagttgaa gtaagagaac taacatttac caaatacctt gcaaagccag ccattgcatt 25620 ggtattaggg gaactggtag actgtgctgt tattagtacc ttgcagtcag actggcattg 25680 ttcaaatccc agctcagcca cttgctggaa gaaacaatgg tcatgctgag cctggactgg 25740 caggactcca gatcctgatg acatatcact gttttatgta gccctgttgg actgatttca 25800 cttcttttta gtctcaggat ttaattcaca atgagttgtt ttttggtttg tttgtttgat 25860 tttgagacag agtctcgctc tgtcacccag gctggagtgc agtggcgcga tctcagctca 25920 ctgcaacctc agcatcctgg gttcaagcga ttcttgttcc ttagcctccc aagtggctgg 25980 gaccacaggc atgcaacccc tcacccagct aatttttgta taggcgggtt ttcgccatgt 26040 tgaccaggct ggtctcaaac ttctaacctc aggtgatctg cctaccccag gctcccaaag 26100 tgctgggatt acaggtgtga gcactgtgcg agcccacaat gagtttttaa cacttactgt 26160 tcctcatcag agatgccaat ttgttaggaa aacaaagtgc atccctttca ggcttcatat 26220 ctgcttagaa aaaagcacaa tcctataaat tacgtaatca tataaattag ttgagtaata 26280 caaaattatt tttcctttta tctgactttt ttttctgaat aaattacctt aaacctggct 26340 tcagtttgct cataagctcc tgatatttga acaggtatct gcccaacaat cagagagaat 26400 tagtcctctg caccttctga gaggtattaa aaaaaaaggg ggggaaagaa aaagaatcag 26460 tccaattggt agattttaaa tggctcattt aaatactaca agtttatcag tctctaaatt 26520 ttcagcctag gaaaatttca gccaggaatt tgatattagt cctgatgcat cacgaaagta 26580 cggaaactca gtttctacag acccagggct tcctggggtt acctcaggcc acttatatct 26640 cttatctgtg cttttcctta gctgacattt ggttctagaa tgaaatggaa gtcaggaaag 26700 aggaaaatga tgatgtactt ccccactccc aacacacact tgtctttagc ctaaacattg 26760 ttttccaatc cagctgtcaa acttcaagta tggaagagga ggagaaaaat cagctagcaa 26820 atatatccag atttcctgct gggcaccaaa tgctaagcag ggtaggccaa aaacatttaa 26880 tcaaaaaaac aagatccacc acggttttta ctctcctaaa gtaaaatata aatttggagg 26940 tgagccaaag ttaaaaatat aaaaatatag ccagtgtttc tctcctactt tcctagggtt 27000 gctaggtttt gggagcctgg gatgggggaa aacagtagag gagacatact tattataaaa 27060 cattcaaaat agtgaatggg acatacttat tctaaaaatt tacttgctgt ttatctgaaa 27120 ttcaaatgta actgagtatc tagcaaccct acatcctgat attcaacttt cctactcccc 27180 tggtcatgac tggcttgggc aggagagatc tttgcctggg tagatgttgg gaggagcctg 27240 gtgaatgtat tccttcccag gattggtctt ggctctagtt ctggagcctc tgttggaaga 27300 atggagaagg gctccattcc aaaaaatgga atagggatct ccttccctat gtttggaaaa 27360 cactggtcta aggctttcaa caatagcctt gaatatcaat gaatgtctac ttagcaatca 27420 tcttttccag atgattctta tgtcttaaaa taatgttact tcaagaaggt gcctaattgt 27480 aagacatact tacagtaata gtagttgggt tgtgatgcaa tttgataatg tgagattctc 27540 ttagaaaata aaattagtaa taaataacta cagctgagtt tataatctta ataaattaag 27600 gtagcttaat ttaaaatgta taactaaaca aaaactaagt cacaaaaact ccttgatgac 27660 atgaataaca tacagcaggg agacagtagt aagtagtggc taaggggaaa ggctgtggaa 27720 ttacaccacc tgagtctaat atctaacact gattattgag gtgacttact gaagtttcct 27780 cacctgcaaa ctaagttaca acctattgtg tttttttaat tgattgagat tattaacact 27840 ttttataatg cctggtccag agtaatgctc caaacatttt acctatttta tatgctaaat 27900 ttaaacttaa tctttttggg acttaatata tatccatgca catcgagcat attttaaatt 27960 cagaaaggaa accaatatgc cagcagaaat aaaacaaata ttcttgtttt caaataaaga 28020 tcatttcttt atgagaaaga tgaaaattaa cgatctttta gagatagttc aatgttagcc 28080 actcacagtc acaggtttaa accgtgaagt tagtgtttat ttttatgaat ctaaaaacaa 28140 ttgttcccag ccatggcatg aagtcttcct attgccccaa cccacataaa cacactagaa 28200 attttcattc ttagggaggg atagggaggc tgggggctac tgaatggaca ttttgttagt 28260 taagagctca ctcacaggct gaaggagtgt ggaataggtc caccattagc tattctggcc 28320 atacctctct tagagattgg ggtcctggtt accaacgaag gaccatgtgg ccatatccag 28380 agggttggag caggtctcag ggcccattgc ctggcacacc tcctcccaga attcctgagg 28440 tataaccttc tcaggaagat agcagagctc ttttctaaca ctccgctatt tctggagagt 28500 agtgagtata ttcccctcca ggccttttca cttttattca gaaacacagg gaaaataata 28560 aaagtctgtc tgtattatga ctagctacaa caggtggggg ttttctttgc agtaatattt 28620 tcaagtggta tcacctagca gctggattcc tttgccttaa cagaattggc accctaaaag 28680 caaaagagat ggaagcactg ggagtgataa actttgtcag tttagaatca atttagatca 28740 gtttaaaacc attcaaactt gacacattca aaagctttca atgctatcca ctaagaaatc 28800 atatttgagg aatttttttc cattaaacat ttagtctggc ttaaatatag taagatgcta 28860 atcttttcga aacttgtttt tctttctttt tgtaaaagtc agttgagttt aatataacaa 28920 aagggctgaa taccagaggt agagaaggaa gtgtcccagg cttggtttca agacaactag 28980 gtcctggatt ctacaactaa gtgattttgt gaccttgagc attactagcc attgtgagcc 29040 tcatttataa aggagggata aagattaaaa ttatgaaatc tttctgtaag taattggcac 29100 acagaataga cgttcaataa atgttaactc tgtagcctag gagtgatctg gttacaagct 29160 ttgttaaaac tccttcttta aggaaatgta aaaataaatt ggtactgtca aagcttttat 29220 gcccaggcca tgtagagatt atcttccttc caaagaaact aaaatggatt gagaagacaa 29280 atatcattcc aaggaaaggc tagaagtctg caaaattata caattgtact ttagtgcacc 29340 aaagattaaa aataatgcag tcagaataac atttatttca tctaccagaa tgttacccta 29400 tttcttgcct ttgattagtt taagaatagg aaactaagat agtacagact tataaagata 29460 taacgtattt ataaatatgt atctttgcat atgcaaatta taatatacat attttaaaag 29520 tttgcttcag tgaaatttag agcatgagca gacaacctat ttttggtgaa gagtcagaga 29580 taataaagtt tttagctttt gctggccaca caagctctgt agtgactact tgactctatc 29640 atggtatggc aaaagcaggt ctcagggcca cagacaatag taaataatag gatatgattg 29700 cgttcccata aaactttatt tacataagca ggtagtgggc aggatttggt ctgtaggaca 29760 cagtttgttg aaccctggcc tagagcatga tatagagtat gcttacaaac tgggcataat 29820 taagataact attctagagg aaaaagaatg tatatgctta gattaactca gcaattacat 29880 aaacacaact gtagtacata catctattct tttagcatca aggcttgctg agttgaaaaa 29940 aaaatggtat ggttctctaa ctatattctg ttgagttgct ggtgtgtaaa tcacattgta 30000 actggccact attacttttt ggagttctaa catatgctta tttgcacatt agggtttact 30060 gtttttctgt gatagacaaa tactgaaatt tgattcagat ccattacaca aatggccaag 30120 acaggatatt ctgtgaattt cctgggaagt atattcaagt atcacttacc tgacagcatc 30180 tgagccattg tgttataagg aatttcctgc agggattgaa ttagttaggc ttagccctca 30240 gtggttttgt aactatttcc cgcattcacc ttaaacaatg ccttttagaa gtggtttttg 30300 ggtgattctt tttctccagg aagagattat aaataatgaa atgattagac cattagagaa 30360 tttaaatcag tagagaatgc taatttcttt ttttgtcata gtaacagagc aagccaactt 30420 aatcagtgcc ctgacaaagc atccagcacc aacacataca ttagaaaggt atctaattcc 30480 tcaccatttt ggtattctaa ttttataaat tttaattcta ttccattttg agagtatcta 30540 gggatcagaa cctttatgga agactaataa ctaggtaaac actattacct agcttaagag 30600 accctaaaat gtcagtgact tcataccaca atggtttatt ttgctcatgt atctcattcc 30660 tgtgtgagtt agatgacccc aatccctcct gtactatgcc cttgggaaca cacatctcta 30720 tggttacagt caaaggagag agttgtagat agaaaacggc acacttccaa gtctttgcta 30780 ttgtgaatag tgccgcaata aacacacgtg tgcatgtgtc tttatagcag catgatttat 30840 aatcctttgg gtatataccc agtaatggga tggtggggtc aaatggtatt tctagttcta 30900 gatccctgag gaatcaccac actgacttcc acaatggttg aactagttta cagtcccacc 30960 aacagtgtaa aagtgttcct atttctccac atcctctcca gcacctgttg tttcctgact 31020 ttttaatgat cgccattcta actggtgtca gatggtatct cattgtggtt ttgatttgca 31080 tttctctgat ggccagtgat gatgagcatt ttttcatgtg tcttttggct gcataaatgt 31140 cttcttttga gaagtgtctg ttcatatcct ctgcccactt tttgatggag ttgtttgctt 31200 ttttcttgta aatttgtttg tgttcattat agattctgga tattagccct ttgtcagatg 31260 agtagattgc aaatattttc tcccattctg taggttgcct attcactctg atggtagttt 31320 cttttgctgt gcagaagttc tttagtttaa ttagatccca tttgtcaatg ttggcttttg 31380 ttgccattgc tttcggtgtt ttagacatga agtccttgcc catgcctatg tcctgaatgg 31440 tattgcctag gttttcttct agggttttta tggttttaga tctgacattt aagtctttaa 31500 tccatcttga attaattttt gtataaggtg taaggaaggg atccggtttc agctttctac 31560 atatggctag ccagttttcc cagcaccatt tattaaatag ggaatccttt ccccattgct 31620 tgtttttctc aggtttgtca aagatcagat ggttagatat gtggcattat ttctgaggcc 31680 tctgttctgt tccattggtc tatatctctg ttttggtacc agtaccatgc tgttttggtt 31740 actgtagcct tgtagtataa tttgaagtca ggtagcatga tgcctccagc tttgttcttt 31800 tggcttagga ttgacttggc aatgcaggct catttttggt tccatatgaa ctttaatgtg 31860 gcacatatac accatggaat actatgcagt cataaaaaat gatgagttca tgtcctttgt 31920 agggacatgg atgaagctgg aaaccatcat tctcagcaaa ctatcgcaag gacaaaaaac 31980 caaacaccac atgttctcac tcataggtgg gaattaaaca atgagaacac ttggacacag 32040 gaaggggaac atcacacatc agggcctgtt gtgggtgggg ggagggggga gggatagcat 32100 taggagatac acctaatgct aaatgacgag ttaatgggtg cagcacacca acatggcaca 32160 tgtatacata tgtaacaaac ctgcacgttg tgcacatgta ccctaaaact taaagtataa 32220 taaaaaaaaa aaagaaaaag aaaatggcac acttgctctt gactcccttg gccggaggtg 32280 gaggtaatac attgttagtt ctgatccttg ttcattgatg agaaccagcc cacatggctt 32340 ccacctactg ctagggactc tgggacatac agacaagcac ataattattt ggtgatattt 32400 ggtgagccct aactgccgca gaaaaacttt tgaagcattt agttctctcc cgagaccaga 32460 aatcaatcag gtaaacatga ataagaaatt tatagtatta tctcagtttt tttttattgg 32520 ctttaacaag agcatatgct gggaggatat ttgctatatt ctgctagttt ccccaattta 32580 aggttgtctg ttttgattaa aaccccttag cccagtggaa agatgaaact ctcatctatt 32640 tagtccttaa tatctctatc actaaatgga taggtttcat gtactcttca gtattgatag 32700 cctactttct aagtgtgtgt gtgtatgtgc atgtgtttct gccattacag tcattgtatg 32760 aaacaattat gtattctgac aacagctagc acagatttat ctatttaata aatgttggtt 32820 gattaataga taaaggcacg tttatatata ccagcaaata cgaagacttg gattcagtaa 32880 agtttgatac cattcaatag cattaagatt aaggatgact gtgacggcct ttagtttgca 32940 tttttagact gcttaatttg ggtcaatgtt tctcaaagtt atctccagtg gtctaaactg 33000 ttaaatctgt tccgaagtct aggaacctat gtcagtcaaa aaagtatgtt tttagacagc 33060 tctcctcacc ccattccgtg tgaagatggc cccactgata ttcataaaaa ataagaatat 33120 tccctcccaa tgaatgttgc tataaggaaa tttgctcata cagaattggt aaatggaaaa 33180 atgatgtcac tataatacat aagtcactat aattcagttt tccctagcac cttaatgttt 33240 atactaccaa tgccaccact tgaatgccaa atacactaag agttggacac agtaagcata 33300 tactcataca gtattgtaag gaattcccat tctccttgta ttcttcctct ttgcctagtt 33360 ttgctgtgtg tgatttcttg gaagggctta tataattggc cccaaactta gttcattttg 33420 cccttgtccc cacaactatt cagccttaac attttcttac ttcattccac tgtaatcatt 33480 tatttagtat agaatttatt aggaatctaa atgcctttaa aattatgcta gtatttttat 33540 ttgagttgtt tcgactttat gttttagcta aaaaggtgta tggactttga gttgactgcc 33600 ccaactctgt ttttatcata agctgtatga tttttatgtg tgattttgta gaaaacacaa 33660 gattgctttt aggaatgaat atatcacatt ataatagaaa tatctgtttt cttgcaactt 33720 aaattgcata tattttatga atggaagaat gtcaacaaca aaattggcaa tgggactatt 33780 tgagaatttg ccatgtggag gccgtttcct gaccttttat cctttatatg ctagagtgct 33840 ttagagtttc caaatggtgt tcatatgtgg aattttatgt caatccttga acaatactac 33900 aaggatcatt attaacattt ctacttgata gacttggaaa tcaaggctca gaggagacaa 33960 atgttttgcc tacagtagat tggtgacaac attctggcta taattagtta ctctattcaa 34020 ataaacatat ttgagcttcg attttactta gggcactggg gatacaaaga taattaaaat 34080 gaaactcagt cctcatccaa ccagttgcct ctcttcttcc tcccactgat tcagggacac 34140 ttccgtttgg actgggcaga gctagacaat ctcaaactca tagaggcatc tgcattgcta 34200 gtttcctaga agagctggag gctgagtatc cggactgctc tgcatagggg atatgggaca 34260 cttaggtggc tcctggccaa gtggcccaag cctgttgctg actggaagtc tgtcacttgg 34320 ctctcctccc tcgccagttc gtattgtagc ctctaccctt gacactgtct cacccagtgg 34380 aaacacagct gcaagagctg cagaaggcct attacttcta atctttctgc ttcgtatgat 34440 cggtaattac accccaggga cacataatga agatggttca tcactgcttt ttatgtgctt 34500 catagtgtga gatagtggac tgggaacttg aatcagagca agaaaattgt tttctgctct 34560 aggtttggtc acttaaacta gccacagtat attaggcaaa atatttcaac tgcttgggca 34620 tcagtgttct catcatttga ggacactgtc tcattagatg gtcgaatagg gacttttcca 34680 gctatagcct tctgagattc ctcaaggaca catcgagttt gtattgcatg gtcaaaagag 34740 ggctccaagg aaccaggtct aacaagcttt aaggtgagtg agttctctca atggtgcccc 34800 gactttcctg acatccttct gaatcttaga caagcctcgg agagagatac tcatggaatg 34860 accaaaatgg tagcaccaga tctgtatgag gtatttaatc attttatttt attttaattt 34920 ttagacagag ttttgctctg ttgcccaggc tggagtgcag tggtacgata ttggctcact 34980 gcaacctccg cctcccgggt tcaagcaatt ctcctgcctc agcctcccga gtagctggga 35040 ttataggctt gcgccaccat gcccagctaa tttttgtatt ttttagtaga gatggggttt 35100 tgctctgttg accaggctgg tctcaaactc ctggccttaa gtgatccacc cacctcagtc 35160 tcccaaagtg ctgggattgc aggtgtgagc catggcacct atccaaatca ttttaaatgg 35220 tgatgattat gtccaataag tccatcttat tctcttgggc atctcaacct tttcctgcct 35280 taggaaaatg gaggtcctct aactcctaag atcttgtcac atgatcctgc tgtaggcaga 35340 acccacacca gttaaatgtt tatttacttg atcaatgttt agcctgtggt tggcttttaa 35400 atatcccaac ggagactgag aaagcagtgc agagagtgct aaaatacaga caaaggaaaa 35460 gaaagaattg gaaactagga gaaaacaagg aaaaaagaag gggaaagtgc tttcagcatt 35520 tcttttcaac ttcctctaca tgcttagaaa acagaattga cttttgtatg tctgtggtag 35580 ctttacaaat aaattaaaca tattatcaac gtttgccaat ttattttaca agtatacgga 35640 atatcattag cacattctgg tgatagtatg tcagatattt aaagagctct agcttgaaga 35700 aaatgggcct tactttaaga gtgctatatt tgttttatgt tctcatactt aatgatctgg 35760 gacctaattt tcttcagccc tgattatgct ttgtttcatg acctttaata tatatatata 35820 gtaatcatta aatcaaataa ttataagtca cttaccaaag gaattaaata tggaaaatgc 35880 atttgaatat gtacatgatt catccacatt ttaatatcta tccttacttc tgtttccttt 35940 tgtctcccat taatgataaa atagctgaga agattgttct ctcttttctt tctttttttt 36000 ttttttttta gacggaatct tgctctgttg cccaggctgg agcggaatgg catgatccca 36060 gcctatggtg acctctgcct cccgagttca agagattctc ctgcctcagg gtcccgagta 36120 gctaggatta aaagcatgtg ccaccacgcc ctgctaattt ttgtattttt agtagagatg 36180 gggtttcaca tgttgctcag gctggtcttg aacttctgac ctaaagtgat ccgcctgcct 36240 tggcctccca aagtgctagg attacaagca tgagccactg tgcccggcca gattgttctc 36300 tcttaatggg ctgataagta accaagtaaa acatattgta cttttacccc atgctagagg 36360 cagcaagccc aagctgcaga atgcccaatt acacaatcct ctattagcca ccaaagagaa 36420 gatactttta aatttgtatt acattattta aatagaaaaa ataaagacag aagatccttt 36480 aaaaagcaaa ctggataaat agtacttcag aattctatat attatttgtt acaactgcat 36540 gtaaacctat aattacctca aaatgaaaag tttagttttt aaacaaagcc tattattgta 36600 tgattaaggt ggataattga gctgcttctt atttttatta tagtaaaata tacataaaat 36660 aaaatgtatt attttaactg ctttaaaatt gtaattcagt ggcattaagt acatttacaa 36720 ggttgtgcaa tattgtgaac cactgtctgt ttcagaactt ttgttactac atccagtgga 36780 aattctgtat ctgttactct tattcctccc ttccctctgc tcctgggaac tacagatctg 36840 ttttctgttc ctattaacat gccgctttaa ataatatttc atataaatga aatcagacaa 36900 taaaaaggta ttttgtgtct ggcttctttc acttagtgtg atgttttcaa gattcattca 36960 tgtcatagta tgtatcagta taggcccatc ttgttttaat gcacttcact ttattgtgct 37020 tcatagatac tgcgtttttc acagattgaa ggtttgtggc ccactcttca cttgaacaag 37080 taacagcaag tgctcatttt gtgtctctat gtcacatttt ggtaattctc gcaatttcaa 37140 aatttttcct tattattata tctgttatgg ggccttgtga tcagtggtgc caggaactgt 37200 gcctatataa gatggaaatt ttgataagtg tgtgtgttct gacagctcca ctgaccagct 37260 gtttccttct ctctctccct tttcttgggc ctctctattg cctgaggcac aaaagtattg 37320 aaattagtct aaaataggca gggcacagtg gctcatgccc gtaatcccag cactttggaa 37380 ggccaacaca ggcagatcac aaggtcagga gatcgagacc attctggtca acatggtgaa 37440 accccgtctc tactgaaaat gcaaaaatta gctgggcgtg gtggcgcctg cctgtaatcc 37500 cagctacttg ggaggctgag gcaggagaat cgcttgaacc agggagtcag aggttgcagt 37560 cagctgagat catgctactg cactccagcc tgggtaacag agtgagactc tgtcaaagaa 37620 aaaaaaaaaa aaaaggaaag aagttagtct aaaataacct tacagtggcc tctaagtgtt 37680 caagtgaaag gaagtcacac atctctcact ttaaatgaaa agctagaaat gactgcgctt 37740 agtgaggaaa gcatattgaa agccaagata ggccaaagct aggcctcttg gtccagttag 37800 ctgagtcatg aatgtaaagg agaagttctt gaagaaaatt aagtgctact ccagtgaaca 37860 catgaatgat aagaaagcaa agcagcctta ttgctgatat atagaaagtt gagtggtctg 37920 ggaaggtcaa actagccaca acagtcactt aagccaaagc ctaatccaaa gcaagatcct 37980 aactctcttc agttctatga aggctgagag aggggtggaa gctgcagaag aaaagttgga 38040 agctagcaga ggttggttca tgaggtttaa ggaaataaac catctgcata acataaaagt 38100 gcaaggtgaa gcagcaagtg ctgatgtaga agctgcagca agttatccag aagatctagc 38160 taagataatt tggtaaaagt agctacactg aacaacagat ttttagtgta aatgaaacag 38220 ccttctagtg caagaaggtg ccatctagga ctttcatagc tagagagaag tcagtctgga 38280 ttcaaagctt caaaggacag gctaactctt cttaggggct aatgtagctg gtaactttaa 38340 ggtgaagcca aagcttattc caaaaatcct agggccctta agcactatgc taaatctacc 38400 tacactctat aaatggaaca acaaaacctg aatgacagca tatctgttta cagcatagtt 38460 aactgcatat tttaagccca ttgttgagat ttactgctga gaaaaagaga ttcctttcaa 38520 aatattactg ctcattggtg atatacccag tcacccaaga gctccagtgg agatgtacag 38580 agataaatgt tgtttcaatg acttctgata caagattcat tctgtaccca tctatcaaaa 38640 agtaattttg actttcacgt ctcattattt aagaaataca tttcataaga ctatagctgt 38700 catagatagt gattcctctg atggatctag gaaaagtaaa ttgaaaacct cctggaaagg 38760 atttaccatt atagatgcca ttaagaactt tttttttttt ttttttttgg tttatgggag 38820 gaggtcaaaa gatcaacatt aacaggagtt tagtagaaac tgatttccaa ccctcatgga 38880 tgactttaag gaattcaaga cttcagtgga gatagtaact gcagatacgg tgggaatagc 38940 aagagaactg gaattagaaa tagagcctga aaatgtgact gaattgctgt gatctcatga 39000 taaaacttta gtggatgagt tgtttctcat gggtgagtag agaaagtggt gtcttgagat 39060 gaaatcaatt cctgaaatca actcctggtg aagatgctgt caacattgtt aaaatgacaa 39120 caaagaattt agaatattcc ataaacttag acgataaagc aatgtcagga tttgaggatt 39180 gactctaatt ttgaaagaag tttttctgtg ggtaaagtgt gatacaaaag atgctcaaca 39240 gcattaatca ttagatattc aaccgtgggt aaaattgcat gctacagaga aatattttgt 39300 aaaatgaaga gtcaattgat gtggcaaact tcatggtttt attctattct gagaaattgc 39360 cagagccact gcagccttca gcaaccacca ccctgcccag tcagcaacca tcaccattga 39420 ggcaaaccct ccacctgcaa aaagattatg actcactgaa ggctcagatg attgttagcg 39480 tttttaatca ataaattatt ttaagactaa ggtatgcata ttgtttttgt agaaataatg 39540 ctttgtgtac ttaatagatt acattgtagt tcaaacacaa cttttatatg cactggaaga 39600 ccaaaaaatt tgcatcactt gctttattgc agtggtctgg aaccaaaccc gcagtatctc 39660 tgtgatgtgc ctgtacttca ttcctttttc atagctgaat aatattctat tgtatggata 39720 taccacattt catgtatcta tttagcagtt gatggacatt tgagtcattt ccaccttttt 39780 ggctattgtg aatattactg ctatgaacaa ttgtgaacaa gttttctctg aacatatgtt 39840 ttcaattctt tgggggtgat atacctagga atagaattgt tgacttgtag ggcaactcta 39900 tgtgtaactt tttgaagaac tgccaaactg ttttccatag caacattacc actttacatt 39960 cccaccaaca atatatgaga gttccaatta ctacacatcc ttgtcaatcc ttattttctg 40020 tttttgtgtt ttttttatta tggccattct actggctgtg aagtgatatc ccattggggt 40080 tttaatttac ctttccctaa taattaatgc tgttgagcat cttattatgt gcttattggc 40140 catttgtgta acttatttgg agaaatctct attaatattt actcattttt taattgggtt 40200 gcttgccttt ttgttgttga gttgcttctt attttaaaag aaatcagact caagaggact 40260 ttagttgcat gggaaatatt ctaggtctgg gtgatggttt catggatgtg ttcactttgt 40320 gataatttgt gcacttatat atttctcaaa aatgagcatg tgtttccttt cttgaatgta 40380 ttagtttcct agagctactg taccaaatta gtacaaacat tagtggctta aaacaatata 40440 ttgtctcaca tttctggagg ccagaagtcc aaaaccaaga tgttggcaga gccatactcc 40500 ttctgaagcc tctatgggag aatcattccc tgccttttcc agtttctgat ggttcctggc 40560 aatccttagc attgcatggc ttcttgacac ttgatactaa tctctaactt tgtcttcaca 40620 tggtcttctt tctccctcat gtttctgttt ttgtatatag gtatcttaaa tactcctctc 40680 ctttctctta taagattacc agtcattgaa ttttggcccc accataaaaa acaggatgat 40740 ctcatttaga catccttaac ttaaatactt ctgtaaagaa cctatttcca aataaggtca 40800 catttacaga taccgatacc ggggattagg acttagacaa atttgtgtgg gggaacacaa 40860 ttcagcccac tataatgaac atatattagg cttcagtttt taaaagatgg ctttaaaaaa 40920 caaaatggaa aacaatttta ctggtcagat gtggtggctc atgcctataa tcccagcact 40980 ttgggaggcc gaggtgggta gatcacttta ggccaggagt tcaagatgag tttggtcaac 41040 atagtgaaac ctgtctttac caaaaaaaag taataatgat aataaacatt taacaaaaag 41100 aaaaaagaaa actactttag aaaaatgtgg tagtctaggt ttctgagtca aaatatctgt 41160 aggttaagga ggaaaaaaaa ttcacgggat gctcaccacc ataaaagtta gaaattctta 41220 atttttgaaa aatgatctca ctgtttaaaa agcacagtta gatggaaaag gggacttata 41280 taaaaaagac tttcaaagga tatttatctg ttgtgggttt ttttttcatt ttttggagag 41340 gaagctaatg aaaacagttc aatactcatt tatgtagaga atatctttca agacattaaa 41400 aagcatattt ttagtattgc caaatacaga gatttctatt aaaatttcca gaagacattt 41460 ttttgtgtgt gttcacactg ttacccatgg cacattcctg gttttttgtt tttgtttctg 41520 tccttaagtg atcaataata ttggtatttg gtcattttga acattgtgat ccttaccttt 41580 ggacttgtta acaactggct gaggattcaa ggcataaaag gaatattatg cttactattg 41640 agcctcagca cctttgtatt ttaatatgac atgtggctga tgatcaacct tgctgggtct 41700 catttcatat atcagttaaa taaatatatg aatgaagtaa tattttcttc ccaagagtga 41760 tatttgattc aatagattaa aagttatttg agtccctaaa cataaaaaag ccagtagggt 41820 atagtagctc tgtggcaagc aattttagta tcagaacaca tgaatttaaa actttggaca 41880 atggccttat tcagaacact aaaagcttag aagcctactc tttagattgt agtgctattt 41940 tggaggcata tcttttttct ttttttctct cagtttttct tttttggata gtattccctg 42000 ttaagaaaca gatgatgagg ctttaattca gtacattctc aaattgttcc cactacaaaa 42060 cttatttcaa agataaactt tggaagtttt cataggtagg actgtaagaa tgttttaaat 42120 aaatcctaat cattttacca gagagtatac cttaaaacaa atttttctgg ctttatttga 42180 caggtttttt aaaaaaaata acttagtcat ttttaagttg attgtagttc atccagaaag 42240 ttactccatg ttggtaaaag gttaaaaatt aagagagtcc aatttttgaa aattttcaca 42300 aagttctttt tatactttta aattagtcaa aggccaagta tttcataaag tgttgatgta 42360 aattgtgtta ctgatctttg atcataatgt ggaatagtag ttgcactcaa gatatgaagg 42420 aaaaatatgt tacagggttt ggctttgaaa taactgacat acagcagagg cactcaccct 42480 aacatacttt ccatctatac gccaggcagg gctgtcagtt tgtggaaagg caaactggga 42540 cctccctcag ctctgccctc ctaataagac catcctgaca caaagcagca attattcttt 42600 gatgacatca ccaccgtctt gcccttattt ttatgtgcat aatggaagat ttcaacttta 42660 aatctgacct agccatgaaa gtcagtgtga gtcctgcatc atgttttcat cctgctatgt 42720 ttttactttc tggtagtgct tttaacacag agagtttcca acttgaaata tagagacctt 42780 ttaggaagtt ttttacatag gaatcacctg tctaatcaac tacaagaggt cacacttttt 42840 tttttccttt gagatggagt ctcctctgtt gcctagactg atgggcaata acgaaatctt 42900 ggctcactgc aacctctgcc tcctgggttc aagcgattct catgcctcag tctcccgagt 42960 agctgggatt acagacgtgc accaccacac ctcggctaat ttttgtattt ttagtagaga 43020 tggggtttca ccatgttggc caggctggtc tcgaactcct gacctcaagt gatctgccca 43080 cctcagcctc ccaaagtgct gggattacag gagtgagcca ctgcacccag ccagaaagtc 43140 acacagaggg ttacccaaac taagtctcaa gatacctgtt tctaatgact tttagatagc 43200 atagacctct ttattgatta aataggaaag agaaaagaaa aaaaaactct agaattttta 43260 ggattcataa aattggcatc acaataacag taatcactta tggctcctaa gaattttttc 43320 tttttttttt ttaaccttaa agattagtta atttaattac atcttaaata catctcgcaa 43380 gtgactacaa attctttgag ggcagagaca atatattttt tttacctttt aatcccttaa 43440 agaccttcta cctttccttt cacatgggac ttttattaat gtccgctgaa tgaatataac 43500 atattcataa tatagtcatg tctatacatt gattaacata tttgttatca actgcagagt 43560 aggcccagtc tttctctttt actctctgtc cttttaagaa ttttaagagc tttttgggga 43620 aaataaagta agaagaaaac aatgagtcat gtctttgtag ccatctagat ttcttagctc 43680 tgttgcctca ttcttcctcc tcattcttcc cccagccacg gtggagaaat aaagttgtct 43740 gggggctcat tactggacta cccaatctca gttcccttct gtactttaga actctctcct 43800 tccctcatct tgatttcact aggccacact ataaccctgc ttcctggaga gaatcagacc 43860 catgtaagct cttgagcctc ctgttccatg gatctctcca ccaagacaag agcctactcc 43920 aggctgccaa cctgagatta gagagttcat actctgattg gtccccatag aattaatcaa 43980 cggtggccaa gagtgtaggt aactagatgg ctcattcaga tctgatactc attcctggac 44040 ttgtcagctg tggcctgggt ggcagagtca cttaaaaaca ttgcagcatc ttcagaaatc 44100 tttggttgga gtagaataga tgccaaaaaa ggtagttgtt ggcttctgat gaaatggaag 44160 ggtcaaatta aataatagct gaggtctcat cccttctacc cataagattc tatgatttat 44220 cactaaaaca atcacatatt aggaggtcat aaataattct acacaagttc ttctaatctc 44280 catattttct tacacctatg gtcaaataca tctctcttgc aagaattata taaccaaata 44340 ttacatacac tatgttagaa taaagaatga acactatcac tagaacttgg aagcagattt 44400 aaatactgaa aaatattata ggtatcgaaa agaccctttt tattctggca gaaatatata 44460 aatctgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tcttctggtg 44520 ctatttctca aaagagtttt tttttggtag attttttttg gttacttttt tatttcattt 44580 tgttaagcca tcaaaagctt tgagattggg ctgggcatga tggctcatac ctgtaatccc 44640 agcactttgg gaagccaagg tgtgtagatc atttgagttc aagagctcga gaccagcctg 44700 gccaacatgg tgaaaaccca tctctactaa aaatacaaaa attagctggg catggtggta 44760 cacactttta atcccagcta cttgggaggc tgatgtggga ggatcacttg aacccaggat 44820 gtggaggctg cagtgagcca agatagtgcc actgcactcc aacctgagtg acggaccgag 44880 actctgtctc aaaaaaaaaa aaatgctttg aaattagcct ttacctgtgt gtactacaat 44940 ttaaaaggcc atctttgaaa agacagtaaa acagactttt actatgaaaa gctaccatct 45000 ggaaccctta gtaaactgac tgttgtctca taaagagtac aaccaagcct aatgcaactt 45060 aattgttcac acagttatgt aagatgtact tcttctataa ctctacagga cttaaaagaa 45120 ctcataatac tatatgattg tattatgggt tccataaaac attatgacaa tgtattttct 45180 ggaaaaatgt ttcctagtga acatgcatac cccagacatt ttacctttct cttaaattat 45240 tccatctgat tttactacct tgctcttgct agagttaaga gttttctgaa agcttattca 45300 gtgttaacta atgttacttt tcctgggcca tttttgttgg tattgagttt tttctttatg 45360 tgatcataaa gttatagttt agaacaaggt tattttgttg caagagtcta tttaggtgta 45420 atatttttta agcaaattga agttgttctg ataaatgttt atctaaatta aaatataact 45480 ccataaacta tgatgtggcc atttaaaggg gaggtatatt aactttgtgg aattgtgcca 45540 ttaaagacaa agaaaaagaa aaaagaaaag cagttggctg gatgaagtag tatagaattg 45600 caaacttaca tgagataata attagaatca ataagacacc taatggaaaa agaatattca 45660 tatgatatat tcattcattc aacaaatttt attaaacaca tcatctacca atgaatctat 45720 gaagatcagg tactttagca atatagaaca atgtacaata acacataaca taagacagtc 45780 catgtgaagg cagttcattc ctggtgtggt ggctctattg tcagcataac cctgtgttac 45840 tttcatcttt ctgcttcagc acctagcaca tcacttctgt tcaagttcac ttcatagtcc 45900 aacagggcag ttgaagcctg tcttagtctg cttagttgcc atagcagaat accatagact 45960 gggtggctaa tataacagaa atgtattctc cctctgctct agaagctaga aggccaaaat 46020 caagttgctt tcagcttgat ttttgatgag gcttcccttc ctgtcttgta aatggccatc 46080 ttcttgccgt atcctcacac ggccttatct ctgtgtacat agtggagaga gacagagaga 46140 aagggggtgg agagagagag agggagagag agacagagag agaaaaagaa ggaaggaagg 46200 aaaaagagag agaaagaaga aagggagagg aagaaagaga aagaaagaga aagagagaga 46260 gaaagagaga agaaagaaag aaagagagag agagaagaaa gagagagaaa gaagaaagaa 46320 agggagagaa agaaagacag aaagaaagaa aaagaaagag aaagaaagaa agaaagagaa 46380 agaaagaagg ggaaggaagg aaggggaagg aaggaaggag agaaagagag agagagatct 46440 ggtatccctt tcttttatta taaggacaat ggtcctatca gattagggcc ccagtggttg 46500 tgatttcatt taaccttaat tacttcccta aaggccctat ttccaaatgc tgtcacttta 46560 gcggttaggg cttcaacata tgaatctcag gggacacaat tcactctatt gagtgaacgc 46620 taactattat acaagagttc ataactgaga gaaggacaaa gaagaaaggt agaagaagga 46680 taaaagagaa agtagaagga cgtaaaaggc attctgagtt gaatcagttc tgcacagggg 46740 atttctggga tatcccatac aatacttcca cttacttttt ttgggccagt atttagtcgt 46800 acagctatgc tatctacctg ttgtcttctg gctgtgtaca ctgctgcccc aagtaaagat 46860 tttattacta atgaaaaaaa cggatattaa gagctaataa gccttcttaa tcatatccag 46920 aactgtgcta ggcgttgaga atgagaatat aagttcttat ttttaagtac tctaaggaat 46980 tcccagtcta acaggagact agtacatgta aaccagttac ctttaatata aagcgataca 47040 tcctatggga taaatgtgta caagttctgc aaaaacagag gaagaatgat tatcaacggg 47100 ggagttgggg agagttcacc aggctaagaa ttgaagaaag gaatttccag aagtggggaa 47160 aactttagca gaagttcgat tgagaataca agatgtttca gggaactgcg catattgaag 47220 ggtggccatt acttgacatt ctgagccaga gtagtaatga gattggaaag gtcaaatgag 47280 ccctcatttt aatgggtcta aaatggtgct taaaaagtgg gacagcattt attgggtgat 47340 gaatttatag atgtgtgtgt gtatatattt tgatacaaga aacccttctg aagaaattag 47400 ttattagatt ccattgatgt cacaaggtgt tctttttgtt gttgttattg gttcgtttgt 47460 tctaatttct gcccttttca agattcaaat cacaacttaa aagcaaggag ttgcaagaat 47520 atatggaatg gtgagaaatg attgatgtta gaaagctttc gaaaattgca atacataagg 47580 aaaattgtcc aatgcacatt cttatttatc tgcatttatc tttctatatc ctgttgaact 47640 ttgccgataa ttgtagaaac accttggcat ttctttcttc catctttata ttttcttgat 47700 atcattagaa atagatgttc agtctacctc ttgcatgctg accaatccta aattgggcga 47760 tgacctattt attttgcatc ttccctgaat gcttaatctt catgaactag aaatggccag 47820 tagaaagtca gtaagtgtta cttaatttac ttccgtattt attaaatttc tcccagagta 47880 aggaattatg agttcctgga gcagcacatg tgtctctttc ttacagaaaa tttcagttcc 47940 atggtgagga ttatttgcac atctctgaag aggcaatggt ccatccagac aaaatagcac 48000 agagccagta cataaaataa gaaagtggac tgtggacaag tcctgacaaa attatggaaa 48060 gaggaactag tgaaaattct agcaagtcag tatcttttct ggccagtaca tttgtgtaag 48120 caaattgaac tttaatcata atatagtgcc aatttgattt ccaaaatctt tgtctttttt 48180 tggtcccgcc ttggaagttg aatctcagtc atgtacacca gaatatgaat gcgagatgac 48240 agctcccata acaaatcacc cttggccaga tttccgccac ttggttgttc attttgccta 48300 cctctgaaat tagcaaatct ctgcctttgt ctacttgtgc cttctcagat ctgctgctcc 48360 tggcccattc cttgatctca atgtggctga aagtattaag attttagagc atgtataaag 48420 ataataaagg tcattcaatc aagctcttct attttgtgca ttttttgctt ctctaagaag 48480 caagaatggc actgtgattt cattgttgaa atagttaaga aaatagggga caattttgat 48540 aaaattagaa aatcttagag aagtatcctg ttactacgtc ttcaaatgta taatgataat 48600 tatacaggaa aatttaaagg catttttatc ataaaatgct tcaagcaaac gagaaaatta 48660 tgaggaataa tatatcaaat agcaatgtgc cctctaccca gctttgcaaa atctaaacat 48720 ttttctgtaa ttgtttattt ttcataagaa ataaaacttt attaggattt ttgagaaagt 48780 ccagtaaaga ccaaacctct tcctcacttg agatcagaac caattgggaa atgacaaaga 48840 atcagactga tgaatcagca tggctgatga attaaattcc cactactgaa ccgtagagga 48900 ggctgtctac actccagcgc cagccgagag cctgacactg gacgaacaaa gcaaagcatt 48960 ttcttaacgt aggcaggctc agttctaaaa gaaaatgaga aagagaggat ggggctggcc 49020 acacagtgtc tccttccaga ctcaccaatc aattagtgtg aaggaagggc aggttgagaa 49080 atagccgaga agtattacaa ccggtgaggc actcacccca tggaaggaaa tgtcagaagt 49140 ggaaagttag catttccctc taaaaacata taaagttaaa gccatgtttt tattcccttt 49200 tagaccctat tttttcctcc ccttctccca tgcaaatgta acctctaccc tgaattttaa 49260 gatccttata tataacaaat acttagtcac tagtgttgtg attctaagta tcagaatgct 49320 tccatttaag ggaaatattg gctgccggtt cttggggata ttgactataa catctgcagt 49380 tacttcagtt tcaagatact cttgtagact aatggaaaga atgtaaaaga tgatgctact 49440 agatagaaat agagtttgga tcgaaggatg ttactgccca actaatgttc taagtgctga 49500 aagatcatcc tggtcttagc aacagcaatt ataactaaga aaacaaagtt tagagttatc 49560 tcaaaacaga aaagaaagca tcaaaaagtt atctctttcc tctgaaacaa aaataagcat 49620 tctagtgacc cttgccttct gaaatatttc aacattccaa gctactgaga cttttcttat 49680 tttcttataa acaaacttta atgcccttta aaatactttc tgatttcttt tctaagcgtt 49740 ttcaggtgaa taacaagtta cattcgtttg gcttattttc tcttcataaa atggacaagt 49800 ttttagttga gcagaggaac cgaaaaactt ctgaatgaag gaaatatttg gtagtgaatg 49860 atataatgga aaattgctat aataagtagc tgggaagaag caaggaaggg agagaaatta 49920 tacagaatca ttttagttta agtggcagtg tatgattaga agcagtactg agacattgag 49980 aaaaatagtc tattacatac cataggaaaa tcaacaatgg catctctgaa tatggaattg 50040 ctagttaaag ctactaggtg actctaggat ggacaatttt ttttaatagg tttttggttt 50100 tggttgaggt acactgtcag agtgtgcaca gtatttcatt ttgttagtta gcttcatgaa 50160 gaccttaatt tattaatgtt aatgattgac cacttgtgtg ttaaaccaga aagtatttag 50220 tcagttgaat tccatcacaa aagaaatgtt atgaatccgt atattttgcc tcctgtttct 50280 gagaaatatg gcaaataaaa aaagagaggt caaactaaat ctaatacctc tttaagtccc 50340 acagcaaaat aaaacatagg taggcctcat tttatgtttt gattatgtct tgaaaacctt 50400 gtatacaagt taaaacattt gtaaaagtct aggcatgctt catttttgaa ataatgtggt 50460 agataactta aaatgccagt aattattttc cagtctaaat aatcacaaca ttgagtcagg 50520 tgtggtgact cacgcctgta atcccagcac ttcaggaggc cgaggcaggc ggatcactcg 50580 agcccaggag ttcaaaacca gtctgggcaa cgtgacgagc acttttctat acaaaaaata 50640 caaaaattaa ccaggcatgg tggcatgtgc ctctggtctt agctacttgg gaggctgagg 50700 tggaagaatc acttgagctg gcgaggccga ggctgcagtg agccatgatt gcaccactgc 50760 atcctaggct gggtgactga gtgagaccct gcctcaaaac aaaaacaaca actacaacaa 50820 caacaacaaa gtcacaacat aatttaatag attttttcat atgttggaat ttcactaagt 50880 gaagaatacc tgttatatgt tatatgttat aggtgatacc gtaaggcata tgaatgatca 50940 tatttctaaa aaacttttta ctttggctcc taaatttcaa taatctaaat aaatactttg 51000 aggtatattt gaatatgttt tttgttttca ttcatttcta ttttattttt atttacatct 51060 gaatgtgttt tcacgaaaca attttagctc caaactccaa attgcactat tagggaaagg 51120 gagaatagct tttggctctt cttgtactat ttgaacatta ggtaactggt tactgtcttc 51180 tgcacacttt taggatgtca ttggttcaat ctcagggtca agtcttaccc aactgtccta 51240 tgtactctgt ccattcatgc cttaaaagaa agaacctgaa gaaaaagttg tacctttatt 51300 agcaggttct tttaaatgaa ttttattaat taacatataa tttcttctca gtaagatatg 51360 tgagctggca acacattgcc aatcctatgg ttatttttgt tagtatgcac aataggtagt 51420 ttcatgggtc aggaaagcag aaatagtata caaggttaaa gaaatgattt tcagttctct 51480 aatttccact ggaattatta aacatataaa taaacaaaaa agaagtaaga taactcactg 51540 tccctaggtg aagcaatgaa agtaagtgaa gtagtaactg tgtctcctgt ttcaccctca 51600 tgcttggaac atgtgtatgc cttcaaaagc tcacatccaa gtcatccaga aaaattagcc 51660 tgttaaatag tataggagaa tcaacaatgg aatctcttag tgcctggaat ttgcaattgc 51720 cagttaaagc tagtaggtaa attaaaaata atttatttta cagtgtatac tacctctttg 51780 ctttactgac cctcaaaaac gcctgctgtg tatactaaca aaaatacctt tataactggc 51840 aatatcttac tgagaaaaag ttataagtaa atgaataaaa ttcatggaaa atattccact 51900 aacgaaagta ccacttttat tcagattctt atacatgcaa aggcttacaa tatcatattt 51960 ctgggtaaat acttaaatag gatgccaccc tgctttgttt tgaagcgtag tacgcctttc 52020 cgtatgcagt gctccatgct gtgcagtcac ggaaattaat gagttcagcg ttcaggatgc 52080 cagggcagct ggagaacaga gttctgtgct catgtggctt acacaaacac acgagttgtg 52140 tttcccacag tgggatccag ggacccctga ggttctgcag cttttttatt tggtgaaaca 52200 tagatccgaa agatgatgct gatgtggtga agggggttgg tttctgaaac tgtttaagaa 52260 ttttagagat caagagtagg tctgagagga gctggcaaag caggcattta tttgtggtgg 52320 gaggatatgg ggaaagagca gatgtctgta gatactacaa aggaaaataa acaccatgaa 52380 agaacaaact tatgtagaaa aattttaaag gaagattttt taagaaagga tgtttgggaa 52440 acactctagg agttattctg ggtagcactt ataaaatggg acaacttctt acagccagaa 52500 tgacctttat actgaaagtc ttcatttctt ttgatttatt ccatcctgtc ccatttaaca 52560 aacttgtatt aaacagctac tttgtatcaa gaactatact tccttgcctc ctttccacca 52620 gacacagata tacacatata cacacactca ctttgaagtt caaataccat ttgtaataac 52680 tggagaccca caggacttta gcactaaaag tcaaaacaat tcgcttgcta tggcaagatg 52740 aagttaaaaa gcagcttccc aggatgaaac ttggaaaatg cttaaatact gaggtgttta 52800 tttggatttg cttttctaaa cttgttgatg gaggtaggta tcttgctgac atattacatc 52860 atttctgatg aaagaatttt agtaagattt cttgagccag attttcttct taacattaat 52920 tgtattggga agttccaatt gtttgaagga gacactgagt tggatatatt attttttaca 52980 tcaaatataa attttctgta tttgagatta tgatgtcatt tccaaatggt tgtgttgctt 53040 ctgtactcat tggccaaggc cctataatta tttgtcatat tttaattctc tttgttcccc 53100 atatctttac cactagaggt ctgtggctcc tccttctcaa ggttatggtg ctataaaaat 53160 actcatttca gatttcaaac caactagaat gatgtagtac tatagagttt ttggattcag 53220 ttatactttg agtcaaattt tatcttttac agcaaccata tacatccaca ctgagatcaa 53280 actcacttaa cctattaaga gtaataaaac tgattaaaat ttccaaccca taagactaat 53340 attataaagt tgttatacat taaggaaaag ggcttccaac tttcacaaac tcttattact 53400 aaaatgtttt tcttccaacc tcctgtattg cctcaaaatg gaatatattt catctgaatt 53460 tagtaggtaa aagtaaattt ggagttatag aaaatactta atatatcacc ttttagttac 53520 agtgagaata tatgacttta ggagtttata ccatgtgaat ggggtgaatt aactctttcc 53580 accaggaggc tttggcaaga ggtaagagct accaagaatg taccagggct caggcttggg 53640 gaagagaggg gcctctccag ctcttcatta tagagctcat actttctaga tatgctgtct 53700 gattctcagg tggttcaggt cggtgaattc cttagtagaa tattaatata ctagaaagag 53760 tcactgcagg gtcaccctgt ccttgtaata gacttgcaac ccttaaaata ggttagaggg 53820 gagtaaattt tcattagagt gaaagaaggc ccaacttgtg attggctcag atcctaggtg 53880 gtatcacaga tatgcatcat gttttgagca actgagatga gaatccaagg actctaactg 53940 aatggaatgg tgtcatctgt actcctcctc cctggctagc tcttccactt agaaggcctg 54000 acaccctcat cttagatttt cttcatgtat gtcattgcag ccaagtttag aaacaggaga 54060 tttgctatga aaataagtcc atgaatctgc tgtctcatcc ccactgatgt aacatacctg 54120 tattgtgttt caagatacag tcatcaaaat tagggaaaag tcctcttttg aaagaaaaat 54180 caactgccaa atggtatact gattctttgg attctaccta cgaaatcagt tagctcattt 54240 tttgattatt ctcttttgct aaatgcataa tttgtatttc ttgcagcaat taatacctga 54300 aagttatttg taagctcatt tcaaatgtga taaactgagg ttcatagagg tgaaatcact 54360 tgcttttttt tttcaggagc atcatctttt tttttttttt ttgagatgaa gtctcactct 54420 gtcacccagg ctggagtgca gtggcacgat ctcggcttac tgcaacttct gcctcccagg 54480 ttcaagcaat tctcctgcct cagcctcctg agtagctggg actacaggtg tgcacctcta 54540 tgcccagcta atttttttta atgtactttt agtagagatg gggtttcacc atattggcca 54600 ggctgctctt gaactcctga attgaggtga tccgcctgac ttggcctccc aaagtgctgg 54660 gatttcaagt gtgagccacc gtgcctggct tagcatcatc tttttatgac tgtatttcca 54720 ggccctacca tatattcaat tcagagtaaa cacttggtta tatttgtgga gtagtggaat 54780 atatgaatga ttgaataaat aatatagatg aaaagattag ttcctgtatc tccagggatc 54840 actatctttc tataccacca aagaatttgc cctaaaacca ttcactgtaa aaacataatt 54900 atgattatat cttgtcttaa tcttatgtca ttatttcatt ccttatgtta aaaataataa 54960 aaataatgtt aattctatga tttctcctat ttctaaattg cataaacata tgtaagaagc 55020 tactgaaata aagcaatagc attttaatac attcccttgt caccatttat ttgataccct 55080 cttgccttgg cttggaattt gcaatattca gaattgcatt tgttgttgaa tattcctatc 55140 tggatattac tagattggga tttctgaccc acctagtcca aagacagaat ttctttatta 55200 agaagccaac aactaaacag gctacagtaa tactccttgg aactcaagga tgcgtacaag 55260 agggtggctt ccttcaatct gtcaacagcc tctgtcacct ccatttatcc tttttctgcc 55320 agtcctattc tcaaatactc cagagctaca agatgattaa gagccatcat gagacttttg 55380 aggattgttg tgagctgggt tgttattttt atttttattt ttattaatca gaccaactca 55440 atagcaccct agttacagaa atcctatgat ttggcctcat aagatcaatg ttgaaatctt 55500 gcttctgtca ttaatgcaac ctggcttttg gcaaatcact caacctctct gagcttcagt 55560 ttcttaatac acaaaaagag gggaatgtct gctgtcctgc ctcacctcct caaattattg 55620 aatagctcaa tatcattact gttattatta ttattatatt ttaaaatgtt tgtaagcaga 55680 aagcactgca gagctgtagg ttgcttctcc ctctttctca cttagttttc ttacatatca 55740 aattccatcc tggggtaaag taattgctca caatttcttt ttataagaga tatccttcaa 55800 caccagcaat ttcatctttc tcttttttta actcttgcat atatagcata tataaccata 55860 tttgaatggg agcaagtctt ttcatttctt ttctacttgg acctataagt tctagctgaa 55920 gtccttcaag aagttagatc tggagctctg tggccaggac ttttctcctt actcagactt 55980 tccagtcatt ccccaaatcc tttccagccc attgctattg tagaaaagtc ttctccccaa 56040 atttgcctct caggagatgc agttatgcag actaatatgt ggctgtcttc taagctcatc 56100 ctcatatcac tttgtactag ccctttctag ttttaggact aagatgtaaa aattgaatta 56160 atatgaatag tggttactac tttggatttg gaagcctgtg gaaatgtggg cacatttctc 56220 tgccttccca agctttcttc tccttatttt cagaatgatg atagtaatgg tatttaatta 56280 tagagttgct ggcaaattaa atgagagtaa cacatggtta gtacacaata tagttattat 56340 ttataagggg aaaaattact ggttttcaat tgctggtaca tgtgaaatca gaatttcttt 56400 tgacatctgt cttatctatg tttatttccc attatttttt gtattttttc tatattgtct 56460 ctgaagccac ctctgtgttt tgcttttctg ggagtggaag tggaggctcg gttgtgaata 56520 agtacaattt tgctttactt ctggtacata aaattccaag acaacttagt ataacaaaat 56580 tcacattgaa ctaaaagtta tgaaaagctg cttttactgt ttactcactc ctttaaatca 56640 aaagaactgg atgtaaacta tttttttatg tcatctcctg ttcttcaggc tcttcggtgc 56700 ctcagaaaac ataaaagagt ctgatttaca atcattttgg gcaaattgcc tgtagaattc 56760 taaggacagg aaatgaaaaa agaagtacag cacacacccc cagacattcc acacaacatg 56820 tagaataaat aaacagcccc aaaaaggaaa ccaaaactgc ttggtcttat gttgaggagg 56880 gggtaccaca aatggctttt ggagaaaatg tattaaagat gatgacatgc tagaaaaatc 56940 cttcaggggg gtgaaattga ccctgattaa agatgatcct tttccccttt tctctacagc 57000 atagtgagta ttttttattt agataacttc cattacctgt attgacatta tgaaaaagaa 57060 ataccacgtt acagagctgt gctttccaaa ccttaatagg cagggctgcc ctggggatct 57120 cgtggaagcg taggtagtga ttcagggaat gtggataggg cctgaggttc tgcattattc 57180 acaagctccc aggtgataca gatgctgctg gtttatgagc cgtggttggt tttcggtcat 57240 cttcttcaac aaaataattg gtggtgatgt tcttgtcttc atctgttcaa gagtggtttt 57300 caactgggga caattttggc ctcatgggaa tttggctgtg tctggagatt tttgattatg 57360 acaactcatg aagtgctatt ggcttcatgt gggtagggga caaggatgct gctaaacact 57420 ctatagtata aaggatagcc ccttataaca agaattttct gacccaaatg tgaatagttc 57480 caaagttgag aaaccctgct gcagaagtat tattttatgc atttcttgta tcaaaaaata 57540 ctttcttgaa attgttcaaa aaataaatac acaaaacctg tgagagcaaa gaataggagc 57600 atctactaca gtcatgcatc acctagcact agggatgtgt tctgcaaact gtgtccttag 57660 gtgattttat cattgtgcga atatcataga gtatatttac acaaatctag atggtagagc 57720 tacacatcta ggctgtatat cgcctatgtc ttctaggcta cagacctcta caagtggtta 57780 ctatactgta tactgtaggt cacggaagca caatggcggc cgggcgcagt gactcacacc 57840 tgtaatccca gcacttctgg aggccaaggc aggtagatca tttaaggcca gcagtttgag 57900 accagcctgg ccaacatggc gaaactcagt ctccactaaa aatataaaaa aattagccaa 57960 acgtggtgtc aggcacctgt aatctcagct actcaagagg ctgaggcatg agaatagctt 58020 gaagccggga gacagaggtt gcagtgaaca gagattgtac cactgcacac cagcctgcac 58080 aacagagtga ggctcagcct taaaaaagaa aaaaaaagta aagcattagt gtgtctaaac 58140 atatctaaac atagaaaagg tacactaaag ctattgtatt ataatcttat gacaccacca 58200 ttgtatatgc agtttgtcat taaccgaaac atcattatgc agtgcatgac tatttagttt 58260 agagagtaag cagcatttaa aactgtcttc aaatatgtga aagactatta tgcagaagat 58320 ggtaaccagc tgttctctat cacgctggaa gaatgaacag gaaatgtaca taaaaggacc 58380 cgtgcaattc acccattctt tttctgcttc cttcatgcca gctagacaaa tctcttcatg 58440 atcttgcaac catatttgtc ctggcctgtg tcttaatact tgcagagacc ctcccaaatc 58500 ctgggtacac attttctttt cactgccaaa tctcatctct ttctcccttt aaaaatctta 58560 attgaaaatt tctatctcca taaaatcttc cttaactaag atgaaatagt tgccagttca 58620 tctttaacta gagctggcat acttcttcct tcaacatgtt atctgtcagt ctgaaaatat 58680 gttactgccc atctgtgtac aaggagttgt gctagatttt gataaaggat taaaaaaagg 58740 taagtaagag agtcattgtt tttaggaatt ttccaatttg gggggaaaaa tctgacacag 58800 ataactatat agtatttaat aattatctcc atgagaggtt tcttaaaaaa taagaaagga 58860 ggttttagaa gtttaaagat tacttctagg tagggaggtc aagaaagact ttacaaatag 58920 atatatgggt gtatcttttt ttttgtttct ttgatgaatt tattcttcaa ggaaaaagca 58980 gttactattg tcgccaaaat ttaaagatta taaattagag tagtgtggat ttaaagtata 59040 tttatgaaaa aagttcatag tgagcaaggg ttaaaatatt agagtgattt aatccactca 59100 caatttataa gactaggaaa gataattttt caggatctat gtggctatat ggtggtttta 59160 acaaagaaga ctgaatttag ccacctctga atgtacctga tgaggctctg taattttata 59220 agacagtgct ctttggaaat aattttgttt gtttgtttgt ttggtttgtt tgagacagtc 59280 tttctctgtt gcccaggctg gagtgcagtg gcacaatctt ggctcactgc aacctctgtc 59340 tcccaggttc aagcggtgcc cctgcctcag cctcccgatt agctgggact acaggggcat 59400 gccaccacac ctggctaata tttgtatatt tttagtagag atgggatttc atcctgttga 59460 ccaggttagc ctcaaactcc tgacctcagg tgatccaccc acctctcaaa gtgctgggat 59520 tacaggcatg agccatcatg gccccctgga aagaattctt agttacatct aggagaagaa 59580 tattttggaa cttcacaagc atactttaaa aaccagtacc aaagcaggaa tttggcacca 59640 tccatttgag atggtgattc tagaacttct ttaggagaca gtcttactta ctaagagttt 59700 ccacaacctg tactatgaga aaattaaaaa gaattaaccc tcatcaaata tgtagtatgt 59760 gccaggcact gggtagaccc tttagatata tcatgtgatt taatctggat aacaactggt 59820 gaatttatca acaccaacat tataaggagg cttcagagaa ttagtataaa tttccatcca 59880 attaaggaag ggaaacagag caaatctcag gcctgcatag gaagccatct ctgagtggag 59940 accatcagct tgccttttcc ttttgaagca gcaaggacaa catctatttt tataaagctt 60000 tacatggtga tatgtgcatt ctctgtagtt gaaatgggaa aatgagctgt tcagagttca 60060 ttgatggcca tggttttctg cagggctcac tgctggaaaa ctatctgcaa ctgtattagt 60120 catatatgaa tctgagtttc tgcctgctct tttccacaca ttctgaaaac ctcagctcta 60180 ggaatggtac agatattaaa ttagtatgga atttttttga atgttaatat ttgtgttctt 60240 taaagtcatt atggtttttt attttttatt gtattattat tattttttta ttacacttta 60300 agttctaggg tacatgtgca caatgtgcaa gtttgttaca tatgtataca tgtgccatgt 60360 tggtgtgcgg cacccattaa ctagtcattt acattaggta tatctcctaa tgctttccct 60420 cccccctccc cccaccacac aacaggctgc ggtgtgtgat gttccccttc ctgtgtccag 60480 gtgttctcat tgttcaattc ccacctatga gtgagaacat gcggtgtttg gttttttgtc 60540 cttgagatag tttgctgaga acgatggttt ccagcttcat ccatgtccct acaaaggaca 60600 tgaactcatc cttttttatg gctgcatagt attccatggt gtatatgtac tacattttct 60660 taatccagtc tatcgttgat ggacatttgg gttggttcca agtctttgct attgtgaaca 60720 gtgccacaat agacatacgt gtgcatgtgt ctttatagca gcatgattta taatcctttg 60780 catatatacc cagtaatggg atggctgggt caaatggtat ttctagttct agatccttga 60840 ggaatcgcca cactgtcttc cacaatggtt gaactagttt atttggttta cagttagtaa 60900 tacagttaag agtggagacc ttccttgagt tttcattctt tgagcttctt tttttttaat 60960 agaaacagct ttcgatggta accttaacca tgccttccat aactcaaaac atgatggact 61020 cttagttaac tctatgtaac tggattttgt ttttctccta aagttgttct acgctgctgc 61080 gtatcattca atgttgatgt gaaaaattca atgactttca gcggcccggt ggaagacatg 61140 tttggatata ctgttcaaca atatgaaaat gaagaaggaa aatggtaagc cagtgggttt 61200 tgttgttgtt atttacttat ttcacaaggt aatgagaaat attatttgac tacagtttct 61260 tttatgaatg aaactttaac agaatgaatt atttatggta gaaaatgcag tctagtcatt 61320 tggcaatgga agctaactta aagtaaaaaa aaaaaaattc cttggcaata ttagaggaag 61380 cgattagtga tttctgttga tgcctggatt gacctcaagg aaggtctgta tccaaaaaag 61440 ctattgttcc ataattatgt tttttggcaa gaattcttta attgttctca tttcagagta 61500 gcttaaatgc acttgtttga aattcagtag gaaggattcg gaggcaaatg agatggtgct 61560 ctgaaagggt ttaacacact tccgtgagtt tggtctttac tgatctactg agcttggtct 61620 aatgtttata atgaacttta ttgggtttct ggtatctacc ttcaaaccct ttaatattgg 61680 ttaagttcat tgtagatagg attttttttt tttttttctg agatggagtc ttgctctgtc 61740 acccaggctg gagtacagtg gagcgatctc agctcactgc aacctccgcc tcctgggttc 61800 aagtgattct cctgcctcag cctcctagta gctgggatta caggcgtgta ccaccatgcc 61860 cggctaattt ttgtatttct agtagagaca cggtttcacc atgttggtca ggctggtctt 61920 gaatttttga cctcgtgatc cacccacctc agcctccgaa agtgctggga ttacaggcgt 61980 gagccatagc acctggccgt agatatgatt tttaaagtat atttaacttg ttgaaaatta 62040 tataaactga atattagagt tcttttgctt aatatttaat agaattttta gtaaatgcaa 62100 tttttgttta attggacatt ctaggaaaga agagcagtag ctaaacttta gtttaataac 62160 ttaaactaaa caagcctaca tttttagtag ctgtaataat aagcaaaaag agatttatat 62220 ctacttggat aataaagatc tatgaatcac tataattatt tcattaataa aaatatgtgg 62280 attttctgca ttttgtttta tcttttagac ttggttaatt tgataataat gccctaaaga 62340 ctataaaaag taatgagttc tcacattttt taagtacatt attttatgct aggtataaac 62400 tagaatttgt tgagatactt cactctttta ttctccttac aaatatctca gatgacaaac 62460 ccaatgctac atgctaaatt tttaagttcc ctttccctcc ctcctatact ctccacccat 62520 cccattcccc aatttttaag gttaaatgag tacagccctc cctctagaca ccagctttat 62580 tcttttagga attatacctt caattcaggt acctctggga gaataatggt gagtagacca 62640 actggtcaga ctttgtgcgt aagctataat aaacagaaat gcagtacatg ttattcttaa 62700 aaagcttaac tttacataaa cacatataaa agttaatttt cactaattac taatagttac 62760 acaaatttta aagaggagta tagcaaatag caagctttaa gacttaaacc acctacttaa 62820 aatgaagtat ctcttttaag gatggttaaa tattgctaaa atattttatg aaattctcat 62880 tttcaatttc tgatatcaga aaaacctgta tgttttcttt cttatccagt cctgtctctg 62940 tgattttaga aaaatctgat gtcagaagtc cttaattata tgaatgaacc ttagtagagt 63000 gaaaaggggt tcatatttct ttttagaagc cttagtgccc ccatttgatc tctttagtca 63060 ctgtttctca tgataagaac ctatcctatt gtgagatttc caccctctaa attctacagt 63120 ccctcctttc aaggcaccag aagtcaaagc aatggaaaat tgaaaaatca ggcctgaatg 63180 aagccttgat gtcatgagga atgtccttcc taaggttatt ctatctttgt agaaagttaa 63240 ggtatggatg aggaaaaaga aagacagcca acactggtta aggaacaaaa gagtgcatag 63300 attggatagt aagaataagg ttgcaagaac gatgttgcta atggtctgtc tgaatgaatc 63360 tacactggac tgaaccatca caattctaca tacatttgtg aggtaatgtt aataagagat 63420 cggggactat gccttatatc ttggtttacc catgaagctg agttgaattg tctctgaaaa 63480 tatttgttgg tgggttaggt tttttttatt tagccatagc ataaatgtgg gtcagtcaat 63540 caacatgtat ttatgtaata cattttatgt gtctggcatt atgctaaatt ccatgggaaa 63600 tatttataca taaaacaaat ataaaagctt taacctagtc aaggacatac atgaaatgtt 63660 taggaataga gaatagtgcc aacaaccagt gcagaataga ctataaattc aatgggaatt 63720 caaaacagga ggagatgatt cttggttctt gacctaagtc ttgaaagatg acttaacttt 63780 caatatgaga agaaaaatgt cactccaagc ttgggaagcc acaagagcaa gggcccagac 63840 ttgagaataa gtgaggtgag tgtgttggta agtaaacagg tctcatattg ggatgaaaaa 63900 agagaaaagg atgatggcag atcttgaaag acaaacacag gagcttggac ctaagatgag 63960 gacgttgaga agccatcata agttgtcatt ttatgaaact taatttggga atttacatat 64020 aaattggatt ggagaatgga gttcctgaaa actaggaaat atatagactc aagaactata 64080 atctggtact taagggatga gccttcaggc tgtattaggg gcaactggaa gaaaaaagaa 64140 aggtgtattc aagacaaatc aagatgaatc agtaaatctt ggtggaagtt tggaaatggt 64200 caatgaaggt gtaggagagg tcagatagat tccaaaattt ctgtactggc tcattgggaa 64260 atgggttgtc attgacagag aaagggaaat tcacttatca ggaagtgggt aagtctattt 64320 ttaaatagct ccagttcaag gtgatttcta ggtagttgga aacctcagac tggaatgcag 64380 gtaagaggga gaagttaatg tgttagtgga aatgcctaga aaacaaagac tgattttgca 64440 gcccacttgc aaccctgggc actaccccac atctagcatg aggccttata cataatatgc 64500 actcaatcat tatttgttgg ctgaacaact aaatctagtt taacactctg ttatcatcaa 64560 ttaaaaaaaa gctgcataaa aaataaagtt aaatgtgact ctcctaggga aatgcaacta 64620 cttaggacca gagctgtaat agatttcatc tctacactca gtcttgtgcc tttttcttca 64680 ttagaactat atttaaaagt aaatgttgtt aaaaactatc tttgtggtag gtaccagact 64740 ttacatatta atatgtgtgt aagtttgtaa gcatttgaat gtagatgata tcagaaacct 64800 aaatctcacg ttgacattta ttatttacaa tgattttatg gaaaagttgt gaaaaatcag 64860 agcaaccaaa aagatgtggg caattgaatt taaaagtaag caaattacaa atacctaaat 64920 ttccaaactt ttaaggatag catggtagca gcatattgtt ctaaagaaat ctgggatctg 64980 gtagtgcaaa ataacctgta gaaacatgtt tggatgttct gtaagtgtct ataaaaacag 65040 atagattgca gacttacttc gagaaatgtg ctacagaata attgacatat ttggaggaac 65100 atggattttg ttatttaatt atctctagag gtaggcacct tcataagtca tatttactgc 65160 tcatgctttc gaatttcata aactcatatt taaaaaaatc atcctgaccc atcttacgtc 65220 gtgactatag tacgcctata gaaggagcac ttgttagccc atgacaagta cagtctgtgt 65280 atttgaaaaa catagcttta attctttcga aagaaatata agttgacaga aaaggtagcc 65340 ttatgtcctc tttactgttc agaagtttgc tctgaagtgt aatttatatc ttttgctcag 65400 aagccacatg ctttctcagt agcagaacac atcatacatc tgattaagat cagctgttgt 65460 tcattatgtt tagcatgagc tggagcatcc aagtaattgc aatgtggttc agaagaattc 65520 agaaagaata taattgcctt cataattttg ctttgaggaa aagaaattca aacatgctca 65580 gcacagcaca agccttccag atttccagat ttagtggtaa acatcagcat ggccaggtct 65640 cagccgaacg ggaaaatgtg agatgtctgt ttggggcttt ccactctaat ctgttgctgc 65700 tttgcttcat tccttccagc atgtgtgcct acccttttaa ctgcccttca agcaaccttt 65760 cttgggggtt tcagtgactt cactggacct gtctgatctc aaagtagatt ttcaggatcc 65820 acccttgcca accttcaagc caatgtttat caattatctt gacttcatgc cttttctcta 65880 gaggatcctg ctttatgcca ggtcagggta ccaatgggct catgtgattg atgccctatt 65940 tccaataagt ctgtgttgta aaagaaaaaa gaatccctgc taatgtagag ctattccaga 66000 ctggggagga gagacatttt aagggtttac acaattttct gtaacagatt ttaatatgct 66060 tattttacat tgcttctaac gccttttgaa gttgaaattt cctcattgcc aaacttgtca 66120 tttctttggc tcccctcatt tccacccctc caccttttat gagcaaatca ctgcagttaa 66180 tgggtcactg tgtaagtttc attctctaag atgaaaaaat gcttattcca tttatttaaa 66240 aagaaattgg cgagcagaat ttgcttggca ctctgagagt gactttggct tgaactatgt 66300 attagacatc aaggcagagt tagttgaaaa ggatgttaat gaaataatgt aaatataaga 66360 cactcttttc caagaaacta tcttttgcag ggaagaaaac ataaatatga aacagagaca 66420 tcagacacca cctactcttc aaataaatat aataatgggc ataataacaa gataactatt 66480 gtgaatagca aatatttctg cttactaaat attattataa ttgtagctta ttcatggaga 66540 aaagtgtttc tctcactttg atgatccttg agttgatcag atgtttctcc agaaatgagt 66600 aacgatatcc agaacatgtt ttgatcttct cagtctgcat acaggtcatt acaaaaatgc 66660 catataaaaa gcaagatcta ataggaataa aacgtaataa gttaaaacta acttgcatta 66720 aattttaaaa taatgattct cacagtttat aaaacaatgt gcctgggcct tcaccttgac 66780 cctgtgggtt tgggcggata tcattgttat catctgtatt ttctagacag gaaactgaga 66840 cagagaatga atgtccaaag gtttaatata gcaagtatgt cacagggtca ggatatggaa 66900 caccagcctt ctgacttttt agccaattct ccccctttag caacaaggat tctctagctg 66960 tttgacctgg agaaatgcct ctggtgtcac tcaaaggcat gtatagcatc ccacttaagc 67020 tgaatatata ttctctaaaa tggaaaaaaa aagattttac aatccagacc tcttggctgg 67080 tcacataagt ataaattctc aggtctgcct tattcagatt tttaagtact tgacacagtc 67140 gttaattcat tcattcaata gatatttatt gaatgcctat tttgtgcttg gtactagtat 67200 gagcactaag gatgtgtttg tgaacaaaat agaaaaacca atccctacta ttgtggagct 67260 tatattctac tggggaatag agaacaaaaa ttaaataatg aagttaataa acaggtaggt 67320 tacatcaaat gccagaatag gatcagtgtt gtgagaaaaa actgagcaag agagtggatt 67380 gagaatgctg gagattcctg aaattctgta aaccctatgc taatactttt ctaggatctt 67440 gttattttga tgcagttgga gaaaagtgag gcttccttag gattcaagtg gtaagataca 67500 cgtactttca agcttgttat taaaagtttc atgtttgttt tcaaagaaaa cagatactag 67560 gaaaatacag aaaattagca gtcctatgat ctgctaacct ggtctttact attggtccca 67620 actcccaaac tccctgtctc aatcctgggc tcctacactc taccactttc taagttctca 67680 ctccgcaatc ttcacttatc tcagaatatg caataggccg tggttgagat tgctgtatca 67740 ggtcagtttc caattatcac catatcctaa gtgctttctc ttgccctaga gatcaaacat 67800 aaactccaga ccttttcctc cagagccaaa tgcttgccaa atctcaagct ctctgttcct 67860 gtctataagc aagctttatt ctgagttcta gccacccata ctttctcatt atcttccctt 67920 ttccatcttc attctcctgt ctccacactt ttccctgggc tatccatatc tccctttcct 67980 tctgccttac aattcacaat agctctccta ttagcatgct gtacaagact cacttttcat 68040 cagttatcct agattttccc ccacttgata ttacatgttt tccaactagt gagtcagttc 68100 ttctctacaa acttatattt gttctattca gatgatggaa tcttagaact ggaaaggact 68160 ttgagggcct aactcccatc cactataaaa acaccttccg aaacatccct ggccagctgc 68220 aacccacctc atcttgacca gaggagctgc ctgacagacc tacgtatgcc ttatcagttt 68280 aaatcttcat cgctctctac aagcccacca cccttctacc tcctctgtaa atctcactag 68340 acaactgcag ctattatttt ccaaagaaga aaaagagaca gagagagaga gagagagaga 68400 gagagagaga gaagccacta ggtcaaaatt taatcctcac ttcctgtttc agttaactat 68460 tgctgcataa taagtcattc caatacttag tcacttaaag cagcaatggt ctataaattc 68520 tcaagatttt tgaggattga ataggtattc ccctattgcc tgggctcatc atctggtccc 68580 tcaactgggg ctggagtgtc caagctggct ttcctcacac gagtggaagt tcatgctgtc 68640 agctaaagca ccaattctgt tccacgtggc ctcttatcct ctgttaagca acactgggct 68700 tcttcacatc ctgatgttct cagctttcaa aaacaggtaa aatggaatct gcaaaggcct 68760 tttaaggcct agccttagaa gtcatagtat catttgtgct gcattctatt catcaaaaca 68820 aatcctagat tcaatgggtg gaaaaacaga ttctacctca tgaaataata aaagtcaaag 68880 tcgtgttgca aaagtgtaca caattccaaa ccatcgacca cccttgcaaa ctgctcaata 68940 ctgggctgct cagcgtgctg cctagggaat ggtcgctctt cctcattttt aagacaaacc 69000 tctccttctg gatccaccct gtctacctgc tcagagattc tactccctct cctgtgaaat 69060 caggatttct cttgttactg tttctttctt gccatcattt agccatatgc agattgcctc 69120 catgataaat ttggacacat ctcaagccct taatggtttg tcattgccct gaaaaaaaaa 69180 agccacattt attaacactg cccatctccc tcatttttag ccaagttact tgaaatgaaa 69240 tctgccacaa acatgtacct ctcattcttg cctcctattc tttatattgt ttccttcttt 69300 ggtttctgtg acactgctgt tttctgattc ttgctccctt tctgattacc cttgcctagt 69360 tttcttcctt tgctcattga aaccttaagt gttatttcac cttcagatgt caacatttag 69420 tgctcttctc actatatttc gaggtggtaa tatttacttt tagggcctca accatgctca 69480 tatcatgctc atacatgttc cacatggttt ctgagatgtt ccccagcaag actgagccca 69540 cttgcctaca gaagtaactc attatcagtg catcctttct tggcctttct tccttcccac 69600 tcttcttttc cccatctcta tacttatgca tacttggaat tgcctccaaa aaacttacct 69660 gaaccaaagt ttttgtcttg gatctacttt tggagaaacc cgaactaaga cagcttatat 69720 cctaaatatt tatagagtta gtccttccat cctctgtact tcctgaatcc aaatcctcat 69780 ctggattact ttaggaatcc atatcttgtc atttgactct aattttgttc ctcttcaatt 69840 tacttatgac acttcaagca aataagcttt gtaaatcaaa aaggtgatca tgttacaccc 69900 ctctttaata gcttcattgg ttcccaactt ccccctacat agaataaagc caaagttctt 69960 aaagctgact atgagaacat tcatgatctg gactcttttt acctctctag cctcaacttc 70020 tactgcagtt atactgagct acttggcatt tatcaaagga gtggtattct tacttctaag 70080 actttgctga agttgcatca agttcagacc tattcaatat tgcaatagta catgtatagt 70140 tgtgcttctc tctctaagtt ataagcaaac taaaaattgt gttttattca cttttgtatc 70200 attttatatc ctcaggacct ggcataaatg cccagcatgt aaaatattgt taataaacat 70260 taattactcc agcctcaaat taaatacttt ctaaaatcgt aggctcattt ttttctctaa 70320 actgttttta actgtaaaac caatttattc cattacgtat tttacaactg aaaatattag 70380 gaaaaaataa tcgtaacctc attaatataa tttgttatat tcttgatgta ttcctgatta 70440 atctttcaac atcgatgtta gttgtttatt catctgaaat aaatacctaa taataataag 70500 aactaacatt tagatagcac atactataag ccaaatactg ttctaagcat tttatataca 70560 ttaacttatt tatttttttg atgatcctct gaaatggatc tccattttat agataaaaaa 70620 actaaatcac agatggagta attgacttgt cctaaccata tagctaagtg aatggtaaag 70680 ccataatttg aactcatata ggctggcacc aaagttcatg ctatatttca tggagaagat 70740 taaattattt aatacacaga aagcacttag aacagggcct agcacatggt ataaattcaa 70800 taaagcctag ctgccattat cagtggtagt ataatgaaca tagtaatttg gtgtctttca 70860 tgttaaatta gggcacagat tttcactaaa ttagataaat tttcactttg agttcgatca 70920 taaataattt ttcatcctac catacaatga atgtacaata tgctatagaa tgatcctgaa 70980 ataattagtt tttatttacc atatttcttt tactctttca taattatata taacactatg 71040 agcattatct ttgtgcatta agcttttccc tcttacttta ggtcatttta tttaggatag 71100 attcccagaa gtaaaaatta tgtattaaag ggtttgagca tttttgtagt tctttataca 71160 aatcagaaat tgctttccaa aggcattata ttaaaaccat gttttagagt ctcaatagct 71220 taatatttac aattgtttta taaaatttat tttcattaat actagcatgc ctatagggcc 71280 tacacaaaat aaatcccatt tcttttcaat atgacagact ttcaaatatt taaattttca 71340 aaatgtgtgc ctaatcaatt tgtacttcaa tgcaacttct cagttctcct gcagacattc 71400 tttctccatg ccgaacatcc ccaactttcc cagcatcttt tgtctgacaa atttaccaga 71460 ctcctaacta tctgagtcat agtctcctaa atacattcca ttgtgcatat gtccctctta 71520 atttagatat ttcagacatg gcctgaccag cacagaacac agggggacta tcactgcttg 71580 accagggcat ctatttccag cactgcagac taaagtcaca ttagcatttt tggcactaaa 71640 atacgctgtt gctcatgttt atgtgctatc atctaaatcc cccatgcctt tttcacatga 71700 actcccatta agtgagggct cccacatcct gcactgatat aaataatagt atgcagctga 71760 gcgaagttat ttatgtaggt tctaagtaaa ctttagttta tttatgttta ttgttccaga 71820 atgttgagat tcatctgaat tcctaagtat gtatattgat atacttgata agtatttttt 71880 tcttgctctg tcttatggtg ctgattgata actatattta tactttttat atcttgacta 71940 aagtcattaa taaagttgtc atctggctgg gcgtggtggc tcatgcctgt aatcccagca 72000 ctttgggagg ccaaggtggg cggatcacgt ggtcaagaga ccgagactat cctggccaac 72060 atggtgaaac cctgtcttta ctaaaaatac aaaaattagt cgggcgtggt ggcgtgcacc 72120 tgtagtccca gctacttggg aggctgaggc aggagaatcg cttggaccca ggaggcggag 72180 gttgcagtgg gccaaggtca tgccactgca ctccagtctg gcaacagagc gagactccgt 72240 ctcaaaaaat aaaaataaaa aaataaaata aaaaaataaa gttgtaatct aacacaatcc 72300 caagtacaaa atctcatact atgtaattaa gtcctttgat tgctagcagc cagagttttt 72360 ggatatggct actcagccag caataaatca gcaactgtgg atccacccaa gtatcttact 72420 atttacttta gttcatccga ttcctgaaga tatcatggga gacttaaatg acttgttgga 72480 actaaaatca gttgtgatta tatgtttttt ccattaatta ctgttagaat ggttttataa 72540 ttctgtctaa aaggaaagta agtgatttta acctggatct cataaactat ccttattttc 72600 taagcactta taaactagca catgctaata ttaaatctta tgatgttcca atgtttatat 72660 ttcctgactt ctctataaaa ttagcagttc atcataggaa aaagtcactt atacttccac 72720 atgtgtttta taagttaata cagtagcaga cttagccaat aattattgat tatttcagta 72780 ccccaataaa aaatatgata aagtaatata aacaaaataa taaagcaaaa tctctgaaat 72840 atctatccta catatacaca cacatataca tgtatataca cacatatata tgtatataca 72900 cacatgtata tgctatatat gtatattgta tatgtatgtg tgtgtgtgta tatatacttt 72960 ttaatccaca tcaatatgca agaggtaggc tctctgctta gtttacataa cattaaatta 73020 ctaatagcat gattattatc tgattatgag tgttattgtc aattatctta aaatcagtca 73080 taaaacaact catataaact gtttctcaat gttcaaaaat gtttactgat ttatttaact 73140 tccagggtgc ttattggttc tccgttagtt ggccaaccca aaaacagaac tggagatgtc 73200 tataagtgtc cagttgggag aggtgaatca ttaccttgtg taaagttgga tctaccaggt 73260 atgtaaaatt aaaaaaatct ggttttaggc caggtgcggt gagtcacgcc tgtaatcccc 73320 acactttaag aggtcaagac aggcatatcg tttgagccca ggagtttgag accagcctgg 73380 gcaacctgac gaaacctcat ctctacaaaa tatacaaaaa tagctggatg gggtggtgca 73440 ctactgtagt cccagctact caagaggatg aagtgtgagg atcgcttgag ctcaggagtt 73500 tgagactgca gtgaatggta attgcgccac tgcactccag cctgggtgac agagtgagac 73560 cctgtctcaa aaaaaaaaaa aaaaaaaatc aggtcttaaa ttatgcccag tattctcact 73620 gaaaacagat tttgggctgg gcgcagtgtc tcacacctgt aatcccagca ctttgggagg 73680 ccgaggcagg cggatcacct gaggtcggga gttcgagacc agcctgacca acatggagaa 73740 accctgcctc tactaaaaat acaaaattaa gctgggcata gtggtacatg cctgtaatcc 73800 cagctactta ggaggctgag gcaggagacc tgcttgaacc tgggaggcag aggttgtgtt 73860 aaggcaacat cacgccattg cactccagcc tgaggaacaa gagcaaaact ccatctcaaa 73920 aaaaaaaaaa aaaagaaaag aaaaaaaaca gattttaatc aactcaagaa aatattagaa 73980 gtaatctgtg tgtcagaatg gtcgagcggt ctaaggcgct gagttcaaga agtaatctat 74040 aatcattttt catataatca tttataatct ataatcattt ttctataatc atttatcttc 74100 cagattgaca tagaatgcca ttttgattcc ctctgtcctt aatttgcttt agaaagtcat 74160 caaggagcat acataaatta gaataccgta ctaattttat aacttttaac tctctgcatt 74220 tttcagaatt ctttctaatt cagtggtaat gtgaaagaac ttctccaaat aaacctgccc 74280 accacattcc ctccacaaaa tttaacttag tgcctggttt tcaagaggaa atagaatcag 74340 aggaattgta atagataaat ttaattttaa aaatagaatc acacaagata aatttatatt 74400 gaaatagatg tatttgacat aaatagtagg aatgtgaccg gaaaattcct actaaaatta 74460 tctagaaatt agaaccctgt caatgttcta tacaatatta catactatgg aaattattta 74520 tagccccaca agtttatttc acatattgta tttttcagtt ctcctttttt tgaattttct 74580 atttgtttgt ttttatgaac tttttttctt tacatgcata agcatactta taatagctgc 74640 tttaatatcc ttgcctgata attccaacat ctggaatatc tcaacatcac tttccattta 74700 ttacctttcc ttgaggttgc atcacatttt cctgtcttgt cttgtaattt tggatcataa 74760 cctggattat atttttgaat tacaggtgtg gagattctag attctgttat atgcctgtga 74820 atagtcttaa ctttttttat tagcaggaaa tttacttggc tcaactcaat ttccaagcat 74880 tgactttctt gcaatgacaa gtagttaaaa tctctattca ggttttattt cagctgggct 74940 atttgaaata tactctgcgc atttactatt caagtcatct agttatttgg ataaaatata 75000 tatgcatatt atagaactgt tgttttgtgg ctctttttct aagatatact actctcctcc 75060 tcattttgca gctgctgtca ttgccctcaa tctctgttct ctttttattc agtacagtaa 75120 gactaggagt tctatttgag ttttagccac tgaccagggc cttccctagg ttgggggtgg 75180 gttaggggtg ggggacaaaa acaaaacaaa acacaaaagc acaaaactca tttagtgcca 75240 gtatcttctt ccaagtatgg attcccctcc attttctgcc acctttctag tgccttcagg 75300 tgattgtttc atgtattttt tttaattctt cctagaattt atagttgtga tttgcagagg 75360 agctgttttg ttaggagtta ctcctccctt actggaaatt ggaatagttt taaaattagg 75420 ctagagattt tagccacatc aagtacagta gggaagtttc cactgtagtc cctaattgtc 75480 ccaggaatgc tttttctggg tcaagctttg tatataaaac tctaatccag attatacaag 75540 atcaatgcat acaatcgccc agctctaggt gctttcaaag caaaccagac taaactcttg 75600 gacaaaggcc attgcgcaga tcaggaagtc taactgacca ttccagaatc tctgcttcca 75660 ttccccactt taaatccaca tacagtctta acatgaaaac aacctctgga acaaacagtg 75720 agacaaatct ttctcaacct gaattttgcc tctttctaat attccactct actaagcaga 75780 tttagaagtt cttgtttttc ctgtccagtc tttttttctt ttttagtgtg agaaagtgaa 75840 acttcttgcc aatattgtta ggctggcatg cttcatgctt caggacccaa cattcccttc 75900 agaatgtcaa atgcagtctc tttactgtgt ttcctttatc aaaactttct ggacactgct 75960 ctaatattcc tctagtttcc tttgtcaccc aaaggatgtc ctcatgattt tggaagtcat 76020 ggtcaaaaaa ctggtgtttg agttttcttt tctgatcttc tacccatttc cccttttctt 76080 gccaaaaatc gtgtttcatc actggtcatt tataacaaag ttataagatt acattatatc 76140 tacagtatta tgagattaaa aactttgctt taattagcaa gaacgtgcaa aaagcaatcc 76200 cacattctca ttgccctgct agttctgcat tctttcacag ttcagcaaaa ctatctgaaa 76260 tagtttctgg gacatgagcc aactcttcag ccttagcttg ttcattatat tccttaagaa 76320 gacttggaag actaattagt tgaaccaaaa gaagaatgtg ctatgatatg agcaaaacaa 76380 atagaatgtc ttaatgagag atgcttaaaa tttcactttg tgaaactttt cctccctcat 76440 aaaattttgt tctattttta gttaatacat caattcccaa tgtcacagaa gtaaaggaga 76500 acatgacatt tggatcaact ttagtcacca acccaaatgg aggatttctg gtaagaatgg 76560 agagaatgat atttattgac aacagatatg ctatcatttt aagtctttgt aagatctgtt 76620 atataatttt cagtctaatg atttctaatt ttaaaacaat tttttaaagg cttgtgggcc 76680 cttatatgcc tatagatgtg gacatttgca ttacacaact ggaatctgtt ctgacgtcag 76740 ccccacattt caagtcgtga attccattgc ccctgtacaa ggtacagatt ttatgcaatg 76800 ttcttgcatg tttgaaaagc ctatgcaatg aatgagacgt atgtatacaa aggaacatac 76860 caaaaagctt aaagtatttt cttagctacc agcattacca atttaggtaa atgtttgctt 76920 tgccagtata taacaaaatc tgactgctat ttttggaatt gatattagtg taaataactt 76980 tacaaagtca tttttaaaca tcatagataa agctgtcatg ctgcttatat ttaaagaatg 77040 agtctctttg aagaaagaag taacttcatt tgagatatgc tcaaaaactg ttttataaaa 77100 acttatataa aattcatatt gagaaaattt gcaaagataa ctctcataca atactaatta 77160 aaattcagta ggtatgaatt ttatcccaca ccaattgtta ttgaaagcaa tgaatatttt 77220 tatcatcttt actttttcga aaactatttt ttattgctaa aacaatgtgt ctactttgga 77280 gaacatcagt tcatctttta aaatgaactt ctttcagcca tgaaagcact tcatatgcct 77340 ctgaaaaaaa tagattccaa atttgacaat tgactccttt tattgcagaa tgcagcactc 77400 aactggacat agtcatagtg ctggatggtt ccaacagtat ttacccatgg gacagtgtta 77460 cagctttttt aaatgacctt cttgaaagaa tggatattgg tcctaaacag acacaggtat 77520 gtgactttgt gttttgattt ctgttgttct aaagataaaa atgcacaaat ttttaataaa 77580 accaaatatt ctgaaagcaa attaatcaat aaaactaaag ttgagaatga attttatatc 77640 catttcctgt tcttatttct gataaaaagg acattacttt aagctgtgtt attttctatt 77700 tttttctttt ttcttttttc tttttctttt ttagacagag tctcactctg ttgcccaggc 77760 tggagtgcag tggtgcaatc tcagctcact gcaaccttca cctcccaggc tcaagcaatt 77820 catatttctc agcctctcca gaagctggaa ttacaggcat gcgccatcac acctggctaa 77880 ttttttaaat ttgtaataga gatggggttt catcatgttg gccaggctgg tctcaaactc 77940 ctagcctctg gttgatacac ctgtctctgc ctctcaaagc attggtatta caggcgtgag 78000 ccactgtgcc caacctaggc tgtgttattt tctaaacaga aaatattatg aaagctgcca 78060 tttttaatgc acttgaaaaa taactcctat agagttctat aaactcatag tttaattttt 78120 acttaaaatg gatatagcca cttttggtaa tgtcagagcc gggtgtcaga gtttgtaaaa 78180 actaatctga catcccaaac aacccatcac attataatct ctcctctcat attatacaaa 78240 taagttagta actgaccaga ggatactact taaagcctgt tgtcctttct gttaataatt 78300 tcttttccct aagttaaaag aaaatgcccc tggctatctc tgcataaaat caaatagttg 78360 tttgtttatc cccccaatta atatctattt ctaaacacat ctcctttatt gccactaaat 78420 gaagtggaac ttctcacaca gcttttccac tttagatact gagtttaatt taattacatt 78480 taattaaata catttgactg atttaatgtt tattaaactc atatgggcat atatattaaa 78540 atacagggca gacataatgg ataacaggca aataaaatgt caaaatgaag tcaatgcctc 78600 aggtcaggaa ttagccctag aatcagagcc taaaagattg ttgtgtggtt tggaggctgt 78660 agagagcata ggagacttta agattatagt actgcaatca atacagtgat cttccttttt 78720 tttttttttt tctgaggact ttactttggg agaagtttct gaggcactga aaaagcagac 78780 tgactgcgtt aatgtttgcc acacctacat taaatttgga acataatatg tgcacatata 78840 tatacataca tgtgtcttca tgtgtctgtg tatatttatg tctctcttaa tattttgata 78900 tctatgtata tataattttc taaaaggatg gtggttgaaa atttcaaagt tgaactcaaa 78960 cttcaaagtg aaatgtattg ctgcattcca aggctgaata ggtctctgta gagagtgagt 79020 ggaagggtaa ggttataaat atcctgctgg acaatagaga acttgttgaa atcagtgtaa 79080 aatcattaaa aatgaaatgg gcttttacgt atcacaaaat gtaattttcc ctggaagtga 79140 cttatttgca attgaccttc tcaagtgaaa ttactagtgg atggtagggg acctttttat 79200 cccgtcttgc tacagggtac agggcagcct gcatcttaac agaccaactc caggatgtga 79260 cttgctcttc cttctggcac ctgttcctca tggacctcct tttttccctt ctgagaccac 79320 tcttccttcc tcctttcctc gcttccccta tcccttctct ccttggccaa taagatagca 79380 tagagtcata agattaaagc tggaaagaat cttaaaggtc atttggcccc caacctcaat 79440 ttatgaagga gacacgagag gctaactgat ttgtttaagg tctttctgct tgctgatggc 79500 agattagaac acacacagct ctctaattgt agcccagttt gctgttgttt tttttctttc 79560 tgagggctct acttctagag aagcttcaga gccagtacca tctaatgccc ctgaatagta 79620 gatttcaatc cttttctatt tcatgaggat gactgtcctc atccttcctc aggcagcctc 79680 ttggctgaaa ccgtgctagg cttggcaatg actcactgcc tggactaata ccttaaatga 79740 aatggcttgt gttcccgctt tctccacttt tgcccatgat gtgctttctt tccttcttct 79800 tgttttgtcc atcccatttg atcttcttac ctaacttttt ccttccaaag ctaataacat 79860 gcttgaaata ttttttacaa tttattatac agccatctaa atattttatt ttacctttaa 79920 attcacttat gtatattact cttaaaaatt aatttatttg tagctatttg tgaaaattag 79980 tgcagctgtg acatgtctga agttggtcca caactttaga aagaaaatcc atacggctct 80040 tttagaacaa taattacagc ttctgtgaag atctatgcca gtgactccat tttgtaaaga 80100 aataaataac agtcaattgc ttatatgctc aagctattct tctgcaattt cgatgttttt 80160 cagttagaac tataattaat ttacatttct gtgttgagag tcctaaaaga ggagctattc 80220 tgcctgtcca ccagaggaat tctagcctgc cagagtgggc aacatgaagt tatatgtatt 80280 ttctggaggg aacaatggct ctattcagac aaattcagga gggcccttgg ggtccagatg 80340 ctaccagtga atgggaggaa aatgaactta ccctgcagca gaagagttca gttacattta 80400 ccaagatcca ggacctcaat ccacagagaa gaatatttct gaatgaagca ccctgcacag 80460 tgtcgtttac attatcttct gacttcaccc aagggaacct gatttttaaa gagagaagct 80520 gattatattt ctgaattttt atgtcacatc ttgctttcat cattgattgt ggagcttaac 80580 catatacatt cattcattta ttcagatgta tgtactaagg gcttactatg ttccaagctc 80640 tatgctatag cttgggtaat agtggggaag atgacagaca agggtgatgc cttaatggtg 80700 cttctgtcta atgccatgtt tctccaatta tggctcatgg aatttctgct tccaaatcac 80760 tgggatgctt gaactatacc ccagattttc aaaatcagaa tctctgaggg tggggctata 80820 agcctgcatt atatataagc aacccatatg attcttttct gtttgtttgt ttttttgaca 80880 aggagtttca ctcttgctac ccaggctgga gtgcaatggt acgatcttgg ctcactgcag 80940 cctccacctt ctgggttcaa gcaattctcg tgcctcagcc ttctgagtag ctgggattac 81000 aggcatgtgc taccatgccc aactaatttt tgtattttta gtagagatag ggtttcgcca 81060 tgttggccag gctggtcttg aactcccgac cacagatgat ccgcctgcct cggcctccca 81120 aggtgctggg attacaggct tgagccactg tgcctggccc catatgattc ttaaacagat 81180 taaagtttga gaaacactgg actaaggcat aattattata ttagtgtgcg tgagtgtgtg 81240 tctgtctatc tgtgtttgct gcatactgta gataataggc acctcaagag caaagtctgc 81300 atcatcttct tatcttcgtc agtggccagc ccagtggttt actgtggcac agtaagtcct 81360 caatgagcac ttgttgagta aatgtttgta tcatattgag tccagttttg tatttttctc 81420 tgattattgg acatttaatg agtctttttt ctataactgg tattttaaaa attattttaa 81480 gtatattact ttatacttta ttctctagta ttcagtcttt tctaatcttt ttttttctat 81540 tttggcttat gttttatcag tgactaaatt cataaataat tctctaaaat gaagagattg 81600 gaaaggacat atttaccaag ccattgcttt tgctaaataa catttaatag ggttttaagt 81660 ataatgcatg tgaactcttt ttaaagtttg atcatctttc agtggattca gaaaagaaat 81720 cctgtcatag aaaatttgga aagacatttc cttttcaaag aaaatatgtg ctgaaaagca 81780 tgcttatctt tcatgtagtc ttacagtaat tctttccaaa aactgtttac ttgacaatca 81840 attctttttc ttgattggtt gctaatgtaa tttaaatcca tttgatttgt ttgtttgttt 81900 gtttttagtt ttatttgttt cttttaatga aagcattcaa ttccacccta tgattggcag 81960 aattaacttc tggaatttat tctccccttt atgtattcta tctctgtttc tgaaaggaac 82020 agatgtaaaa atgaattgtg agaaagatta cccagaggag ggtgcaaaag atagaaagct 82080 aagagctgga cagagaactt ttagactcct catccatacc aaatttctaa aagactatga 82140 atgtagttgt aagatttgta gagaggattt ctctgtagaa agagcctact cagaaaggct 82200 tcagtggggt catacacatc ttagtatgtg tatactggag ttgggacaca tagttgattg 82260 actaatgcct aactcctgtc tgaattgtca gagcatgaca gcagctgtta tgtctagctg 82320 ctgacaggga agtcggagca gaggtcactg cactggagtc agcctgcatc cccagagatt 82380 gttagaatgc atgtgttttc ccaggattgg catgggtact caaaagcaag agccagtgtg 82440 aggtcatgtc agggcctgtc cttagggatt actggaagtg agtggctgcc tctgcagaga 82500 atgcagaaga tctctgtaat tcttaggaac tgaggcagtg ggatgcattc actcagggca 82560 agggtgtagg tgagatatct caatgaaggg agttctccaa agaacccttg aaaaacttgt 82620 acatacctat taggacctga ttcatcttag gataatacca atgcagtaat aatttctcta 82680 tccttattta tcttccctac ctctgtccct ggaaggtcag aaatcacagt tagcactcta 82740 agtgaaaaca agtaggaaaa caaataaaag ccagtcatgc atctttctca actacaggct 82800 tcttacctcg tgtaagccct tagtagaagt aggagagaag atttaactac aaatgcgctt 82860 tgatgtttcg ccttgttggt tttaatttag acagaaccat atgaaagtat tgctgtttga 82920 tctttttttt cccaacctac aaatacagca atttcatttg gtacagccta aattaaaata 82980 tataactttt taaattaaca gacattttaa aactaagaat aaaaaaaagt cataagatat 83040 ttatctttcc atctagggat agcaaaatac ttcactttaa ataaattttg aaggactggt 83100 gggccacaaa taaaggttat attctaatta cacctcctgt atttttgttt gctgtattga 83160 ttagttacac atttggtaca atagatatag attgaatatg attcctattc tctgcagtca 83220 tagatttgtc atttagtaat tgcaagcaat aaaaggcaga gtcaaagata tggaatattt 83280 cccaaagtaa ctgttacctc caaaaaacaa aaataaaaaa aaagaaaagg aaagggggaa 83340 ggaaggaagg aaacttacat taagttttcc atgtgacaat ttagtataca ttagggaaat 83400 acaacacaac gatggaaaca ttcactctaa agagttactc aaaatccatt ctatgtttct 83460 gtgtggccca attaagactt ttgcaagcat agtcaaggaa tttttgtcaa ccaatttttt 83520 acccaagaca gagtaaaggc tataaaattg ccttttaaaa atcacctata aaaacaaacc 83580 tgaaacactc tgagcttgcc attaaagata tgatggtgta aacattatgg aggtcttatt 83640 gatcctcaat acctaaacat aacattgctt ttaataataa atgaagataa tataaatatg 83700 tcaaataagt gtgcattacc ctaaataaaa ccagtaaatt gtgaggcttg atataaaagt 83760 gaaatatact aacggaacaa tgtctagatt gttcacatca aaagtgtagc atagcattaa 83820 accaagcaaa atgaaacaga gaaattaatt aaattttagg aatattattt atctttcttt 83880 ttactgctga ttttatggcc atttccctag aagccttaaa tctggggcct gattcattgt 83940 ttgtaggtct gaaaagaagc ctgagggaga catgcagcca tacctttgtc agtctgctta 84000 cagtttccga atgtggggta gggaatgggg tgaatcttct ctctcactag cctctagtct 84060 ccattctccc acccctccag ccatcaggca ctagaataat cattccgaag tgagttcaga 84120 acatttccct aataacaaac aaaaaagaaa caaataactc ttcttgttgc ctgctaaata 84180 atatccaagc tctctagtgg actaactggc atctgaccac ctggcccagc catttctcat 84240 gcatcctgct tccccttaca cccgcctcag tcaatttttt tttttttttt ttgtgggtgg 84300 aggagatgga gttttgctcc gatctcagct cactgcaacc tccgcctccc gggttcaagc 84360 tattctcctg cctcaggctc ccgagtagct tacccttcag ccattcctgg gcccttgcct 84420 tccttgttca tgaagtgctg tgctcttgtt acttgctttt cctgtgattc cctgctccat 84480 ctcaagcgct gtattctagg agaatttcaa atgtcacttt ctctgtaatt ttctatgatt 84540 atcctaccca ctgttcttga gaaaaatgcc ttcctctcct atgttcccat agcagctgca 84600 accgtgagag cacatttcct tactgctctt atcactcagt agcattgctc tttgtttttt 84660 gggtctgtct cttctagtag actgaattac atgacgacag aattgtgcct tagtcttttc 84720 atttatggaa gatagtctag ggttttatgt ttcctagcac atgacatgag ccatttatgt 84780 tgaaaaaatg ggagtttttg aattttcacc ttctcatgta taaaatcgtt gtttttagtg 84840 acctctttcc cttactttgc ttcataaagt catattgatc cactgagctg gaaggtactt 84900 gcttgtgggg gattcccctg gacaaccctt tacattgtat ttcagtcttt tctttgcagg 84960 tgtttaccca cctagcccta ttcccctcag ccctaatttc tcctatagcc cttgcccttc 85020 tccacaaaca cagtgaatta actttgtttt aacctctcct atctttgcat ttttgagcct 85080 acgtcacttt cattgtagca tcttccatga agcaagagtc cagataaaga tacccttttt 85140 ctagaacctg tatctattat gtatcaactt tattatgttt ctgaacactt gtttccttag 85200 gaaataatca tctacctgta aatcagtccc atttatatcc ctctttataa tgacaaaatg 85260 ttaaacctag cctctgctaa catagcttca gaatggtttg tgctaacagt taactgggat 85320 tgtatcctgt attatcacta catttatatc ctgacttagt cacactggaa gcatgttgta 85380 gggtagggct ttgtaccata gtttgataaa aggaaatata cattggccag acataaagcc 85440 tgagctcttt tcatattagg caattgtgca tcttacagga acacacaaaa acacctcatt 85500 gtttcacctt gtcattactt ctgtaaagga acaattgact tggtaatatt agttattgaa 85560 tgaaagccca gaaacttagc ttatgctggg cattaaaatt tgggtgctgg tgtaaccctg 85620 acttaacaag atagatatag aagataataa tataattatt aattaataga taactccatt 85680 ccttcataac tctttgacta aatatactta tcctagttga gtttctgttg ctataacaaa 85740 atacccaaga ctagacaatt tgaaaaaaaa aaaaggtgga ttatttagct catgattctg 85800 gaggctggga gggccaagat agggtggctg cagctgttca gcttctggtg agggccttgc 85860 gcttgggtca taacatggtg gagaaacagg aatggaagca gccacgtgca aaaagaccaa 85920 acacaagagg cagcctcgct ttgtaacaac ctgttctctt gtagtaacta atccagcccc 85980 acaagagtga gaactcactc ctgtgataaa gtccctcttg actcctcttt ttgcctctta 86040 aaggcaccac ctcccaacac cactccattg gagaccaagc atcaacatga gttttggtgt 86100 ctcggtgggg acaaaccata ttcaagctgt agcagaaaca tagctacttt agatacttct 86160 ttttcttaaa cactcttatc atttaagata gttgttaaaa tcttaaacat gactttcagt 86220 ttcataagag actaatccaa aaggccctcc tttcagtgtt ttctgatagt gtccttcctt 86280 tcatgttcac acactcactt ttctccctct ttcttctctg cacccaaaag aaatgaagtc 86340 attggataat taatttgctt taattgagca gatatttata aagtgtctgg acgatcaagt 86400 attatgctag gtgtcaagag caataaaaaa aatcactgaa atgttgttcc tgattctaaa 86460 atcttccaat ttagaaatga ggtaaaataa tatattggga cagctacaat gcatgatggt 86520 atgtcataaa tataatgaag gtgaatttaa aacacagaac aattagttga tcttgacaag 86580 taagtaagtc ttactgttgt agaacattgt ttcccagtct gaggtgttga atatgatcct 86640 cacaaaaaaa tattacttta aataagaata aaatatacca ggtcttccaa ttagtaatcc 86700 acaatgcatg tttttaaaga ctctgagaaa actttcaaaa gaatttgctt ataagtctaa 86760 atagaacaag tagggatagg agtaagagaa aaccttactc ttttgcacca tttgcaattt 86820 gtgacagttt tcatagtgat aggagaaagg tagagatggg gaggagtctg ccgtaaagat 86880 atatatttaa ctttatttta ctcattgttt tccaagatta tttgaccata gaattctttt 86940 ttaaatcaaa cttagtaaca tacaaaggga tgctagtatt cccaaaaaaa aaaaagtgag 87000 tggatatttg tgtgggggct taccagaaaa tatgattgta aatctcatat ttaagtggaa 87060 tgttctaata agtgttacaa acctcttgtt catgtaacaa aattcatagc caattgtgta 87120 cctgatgtat gccatagcct gaatcagcct ttaggtctct ttggccttgg attgtaatta 87180 tctacccatc tatttatttt gttctactta atcaagaggt ttaaaccaca tctccccagg 87240 aggtaaatgt atcctttcca gttgtctctg aaaaggaatt ttccttctgc atgtgactcc 87300 ttatcccccg tgatattata agaaactgtt ctttctatat tcatctactc ttttactgat 87360 accacaaact gctctttaca atctctggga aagaatgtcc acatttaacc cggttgcacc 87420 tttttagctg tcatccctgc atacccattt ctattcatca aaatgcctag gatatttcca 87480 cctccatgat ttgttgtcat cagctctcta tccaacttcc accatctgac ttttgtatca 87540 tcccaacgta attggctact tcaagtcaaa tattaggatt actggttttt tttttccttt 87600 ttcctctcaa tttctaggat gacttaaact cctttaatta tcatctttga catattttcc 87660 aggctgaggg ccactttgtt tccttccata gtactttcat aatctcttgg ctatttttga 87720 gctggctttc agattcagga agctgaatcc tccttcctcc ttgaggattt tcacgtggga 87780 gagaataaat atgcttgtga ttttctctcc tcttgcttcc tcacgatgtt catcacttgg 87840 ctcacttttt aacttgctat ttaattctca tactttattt gattctgcta catacattta 87900 cattatgctt gttttattag ccttaaatta taagctaagg tgaaatggga actatctctg 87960 ttgaattgaa tctcaccaat attcagcaca acattacatt tgtttgtttg tgatttgacc 88020 cttgtctgta atgaaaatta acactaggtt agtgccaaag taattgcggt tttgccatta 88080 tttttaataa atggtaccct tttctgggga agactcacag cacaccttac tctttctggt 88140 tcctaagaaa acaagcaccc cggtatcagc caggaactac attgaatgtc atttccctga 88200 gacttgagtt tttccactgc tccctcttca catttcccag acttcgttgt atctctcttt 88260 ttctgcttat cattatttcc ctgctatctc ggttttccat ttgcttatgc gaaatgttac 88320 agtcatctag taagaatgtc ttagggtcag ctgtgagcaa agcaaaacag cagtgaagga 88380 taagagaata tcaaaagcca tgacatagtc catactcttt acccctgcct gtccctctaa 88440 agttaggatg tacttgggaa gatatagtgt gcactcaaac agttgagaag aatgcaatac 88500 tcacagacaa gtttgtttca gagttccaag aaggggaagc tcaatatggg ctatcctggc 88560 aacaaggtaa gaaaagtttt gcagagagag tggaactgga attaaatctt acaagattag 88620 cttagtagga gggacaaaga agtgcatttg gtaggagtgg agttcatatt ggggagtcct 88680 gaagatgggg gtgaatggag aatttagcat tggaatatta agggactgaa ggtcaagagg 88740 agaaaactgg attttaacat atggacctag tatttcaagg agtagcttga agttttatct 88800 atttttaaaa aattagaata aaaatctatc ttttaaagta tatttcgaag tcattgatac 88860 aggcaatgga gagttattgg aggtttttga acaagtatgt tataggatga aagcagagtt 88920 tcaggacagt tagtctgcca ggaatatgta gaaggatgtg aagagagtgg aaatgaagag 88980 agggagatca gcagcaaaga gactgaccat tgccatggtc caagttcaaa gcaatgatgt 89040 ctggcctgag ctaaggtaat gaggtaggag gcgagacttg actctggagt cgggctccaa 89100 caccagatca aattgaggac tagataaaac agggatgagg cagaagatgc cttccataaa 89160 cacgcccacc agggtgccat gttagtttac cattgacatg gcaacaacca ggagttactg 89220 tcccattcca tggcaatgac ccaaggactc aaaagttatt actccttccc tagaaagttc 89280 tgcatacacc acctcttaat gtacatgtga ttaaagttaa gtatgaatat aactgcaaaa 89340 ctgccctgag cttctcctct ctgcctgtga ggtagtcctg cctggcagga gcagtcacgg 89400 agccgtaagg ccaccagagc tgtaacgctg cagcttcaaa ataaagctgt tttcttccac 89460 ctctggcttg cccttgaatt ctttcctgag caaagccaag aacccttgtg ggctgagacc 89520 cattttgggg ctcacctgtc ctgcatgagt aggaatgcag ggacacagtt gacagctgcc 89580 ttagatccag ctcccagaag caaaccctga gaggacgatt cacatgatag tgatatattt 89640 gtgaggaagc atttccaaca gaaagcagat gaattgggga agcaaaacaa ggtatcaaca 89700 gaggacaaag gaaagtgtaa tttcaagtgg aatccaggcc tcagcttgat atggaagggg 89760 agtttctact tgagtcaagg ggctgatttc tcattccctg cactcaccat tgcctgtgga 89820 tcagggtgat ggggagctga ggaggacggg ggactcccag acactcctgg ttttttcagt 89880 ctttggggta aagcagtcta gtagctcaag tgcagtcatc tgaagagagt ctcaggtaga 89940 gttgttagaa gcaaagtatc cagagcagat aagggaatag gcagttataa ctcatcttat 90000 attttaagat ttacaaagaa taagctttta gaagccaggc acatattgga ggtggataga 90060 tggatgatag agatgtaaaa tttaaagcac tgatttctga cttaccaaca ttttgagttt 90120 tttactattc ctagtgtgaa gataattttt ccggacaatc caatggttca tagtaggttc 90180 tttaagatat gtaaagtgtg ttgtaaatgt aaagtattaa cacacatgtg gcaaaaagca 90240 gtcttgttaa gttggcatct cttcagctcc tctcatgtga gctcatcccc acatgtaagt 90300 gagataaccc tttttcccaa ggagttggca gtttacgaca attagattaa aaccaataaa 90360 tgagaacaac gtggactcat tagtaaaaaa tagttgtagt gtttgacagc gctcaaatat 90420 gcaacctcct ttgagattca tggtcattcc tttaaaagga gaccaggtta caatttgtgt 90480 gacttgtgtc tagcagcatt caaagccaca gaagcatata gagaggagga gataattgga 90540 tttaacccga gttggaagtt agccaagtga gtcattggag ggaaaaaaag gttaaatgag 90600 ttaaatgttt gcaaataaat gattatagtc attggaccat ggaatctagt ctaagtacca 90660 aaaaaaaaaa aaaaaatggc agtattaatg aattagttgg aggtcttgat atggtcaggg 90720 aattagtgaa atgagccaaa gttaatgttc aaaaagaagg acatttgaaa ttgggattga 90780 cctgctgaca aggtcttcca aatgacaagg tcaaggataa gaccttggga gaagatggct 90840 agaggaaaga ttactgatgc tggggaggtc aaagaaatga gagactaggg tattccacag 90900 attatcagtg gatactagat taatagatta ttaagtagat gccaaaattt tcaagaaaaa 90960 caacaggagt aggagggaaa attttcaaag ttctttagcc tcttaatcaa ataaaaacaa 91020 aggggaagaa aaacaaagca aactgtaaga tgtccttaat tgatgagcaa ttaacttcca 91080 caacagtgtt tgttcacttt gatacctaga attagccata atgattatcc aagtaacaaa 91140 accattttgc ttttatttac actgaacatt tatataccca aagacatgtg tatccatgga 91200 tatgtccctt aataattatt cagtgtttcc aaggattact aatcaaaaac tttagggtca 91260 ttgaagaaaa gaattttaaa tttatgcaga gggtaataaa aatgttcctc acattttatt 91320 ataaataaag aaaatatcct gaattgcagt catagatgtg tctttatcca ctttattatt 91380 tttgtgtaat tagttggctg tatcctatct tgttcccaaa gggtcttttg gtcaccttta 91440 ttccaaatat agtagctctc tcagaatagg tggtaaagga tattgggtga aagataaact 91500 cacagaacaa ggctaacctg gacatgaatt gagcagagtg catgttcatt cagctgatga 91560 tgtaacctca tcttacaatt acatatattc tctagttatt tcttatttat cttataccta 91620 actaagcaac tttaggagag aattcatatg ttctattatt ttttacaaaa tatgatatat 91680 gtatttatgt gtttgtttca tcatatactc taacatatct cagttaacta gctagttaag 91740 caaattcatt gagtagccat gaagtggcag tggcactcag cagaagctag caggttgagg 91800 tgactaaaga atggaggatt ttagatagat gcctttttac tgagaggaaa tagggtgatt 91860 gaaagagccc ttggataagg gatacacatc ttagactaga ccccccttcc accacttcac 91920 tatagggatt gggtgttttc aactcagttt cctcacttat gaaacattat catgtttctg 91980 ttattataat ttaaataatt agagaagaaa gttttaaaaa gaccattaaa tatatatcat 92040 agtattctta tttaagcata aggacataat tgctccaaca taaccagtgt actctagagg 92100 gtaactcaaa gatgataaaa attgctttaa atttgggctt ctcttatttg tttctaaaaa 92160 cacaccagaa tatgctttta gtttccaaaa agacttagtg tgaaaatgta catataaaca 92220 gacatgaaat taagactaaa gctttctgac atcagtgatt tcagcagagg agcctggaaa 92280 ccagttactg agccttcatg ctacttaaga ataaggttag actaagaaat aggatttgct 92340 ctaaagcaag taacagaggc aacttcacca acaggcaaag taggcaattg ccttggaaag 92400 aaggcaggct tgttgcaaat tacctccctt acccaagtaa tgaatcacct ggaattcctg 92460 aattaaagag acattccttt gggcaaataa ttttctgagt ctggattttg agataggatg 92520 gttaaacaaa aagtcatctt cagtcacaat ttttaatgca gattagttta ttggttcaca 92580 tcaaccttta aagggagatg tggaaaaagt gtaggagaga tagccattac tggggccagg 92640 aggcaggtgg gaagaggaag aatatggagc aagggaaatc aaatctgggg gcactttccc 92700 tcctgtattt cactgcatga aggctctgca gttagctgcc tgcgttatcc aatctgtgga 92760 ctaaagggaa tgaaaggagg aaggcagtag gaaaggaaga caaaacaagg aaagaaggtg 92820 gagtgggaag ggctgatttg ggagaaatga ggctgcagca aggttagaca aagctcactg 92880 ctcaagtgtg taaccctgca ggctacataa cctgattatt cctccagctt catggtgccc 92940 tcttctttcc tcacagccct ggccatggct cactgccttt ctttccattc ttagggtaga 93000 tctatctctt tcccatcctg gtcttcttca catacacagt ttcccctgta tggacgctct 93060 gcccttctag cactcactct tgaagtctca gcttctgaga agccttccct ggacccccat 93120 tttcagtctg gcctctagat tatattggct gattagggat tttcccatac agtcctttcc 93180 acagtttgca attgttcatg tatttgaatg atcacgtgtt taatctctct ctccttctag 93240 ctttagagaa gctccatgaa ggcagagacc atatcagtgt gtttcatatt ctacccacca 93300 aggcctacca gagttactct gtaaaatctg ttgaattaga taaaccaatc gtttgagaag 93360 tttagtaaca gcatgtttgc ttttgttctt tggactacga acagtcacag aatggctatg 93420 cttattactg tcaaaataga agcatttgtg tactgatagg tttgcaaact catctgaaat 93480 gtattatatc tgattcacat ggttaacctg aagaaatctg aacaggaaat ttggattgac 93540 gtataactca cagtggcttg gtatttcagg ttggaattgt acagtatgga gaaaacgtga 93600 cccatgagtt caacctcaat aagtattctt ccaccgaaga ggtacttgtt gcagcaaaga 93660 aaatagtcca gagaggtggc cgccagacta tgacagctct tggaatagac acagcaaggt 93720 atatggataa aaaaataaac taaagtaaaa gactgcaaaa ataactgctc atgatttagc 93780 cttttggcat atcaattgaa agtttaatat gacaatattt aaagccattt tgtttaaaat 93840 gagattcaga agattaaata atggttacaa gatcagatgt ttgtatgaca caatctcacc 93900 atccttctta tccttctctt gttacaaggg tttaattgat agagaatcca ttttaaaata 93960 tcactgcatc tatattttca tgttcttggg tactaagaca atattagtta atatttgttt 94020 catttatttt ttgttttcaa cttctaagag tctcaatcta aaagaacgga ttaaaaatag 94080 gtctacctct actcaatata tatttatatt ctagaatgtc catgtatttt cagtacttga 94140 tttaccgtta tcgaagctac tagataagag gtgttaaggc gccaaattaa atattgtcta 94200 tttaaaatca tttttagtgc aaagtttgaa agaaatggaa aggatattat catttgtaat 94260 cctctctcct tttttacttt ctttagattc cctccaattt acaacccttc ctttcttcca 94320 tctgcagttt tccttatggt gaacacataa ctcagtctgt ggttgaattt cattttataa 94380 gaacgaacag aattgtcctc tcttacaaat gtagaacact ttatttcctg tgtgttctct 94440 tatctcattc attaaactag caaacttctg aacaaattca aaacaataca aaaatcacag 94500 gaaatgtaat aagtagtttg attaatgtta agaatccttc tgttaaatgt cttcaacttc 94560 tgaactcttg ccttaggtgg aaagctaatt acccatgctc tcacttcatc tgcctgctaa 94620 gatgactgtt ttaagaaggt taaaaaagtt aataatgatc ctgcaaagaa tggattggat 94680 attcaaaatt ttataatttc atgtacagct tttgcctcat gaatattaga aaatcatctg 94740 gctctagtta tatggggccc aagagaaaat aaccacaaac agatggaggt aattggacat 94800 ttacctacct attggatcac ctattggatc accaatttgt atacacaaag agtgcacatg 94860 tttaggtgta ccgaatgcac ccccattcaa taatcaatta aatgtgactg cacattcgaa 94920 gtaagtcaaa gtgttctttg aaacctctga gcctgtaggg agctgtacgt tttccaaagg 94980 caaccattta agaatgaata ttcatctctg aaaactaact gaagaaatat tctggctgct 95040 tttgcttctg cataaatacg gctctaaata ccatgtccct atgtgttttt tgcctctgtg 95100 tttcacaaag ggtatagctg tgggacacag agtttattga attttgatta tacattaaaa 95160 ttctgtagtg atagtaccaa gtatttttct cctacattaa ttaccttttc atgtttaagc 95220 acattttaat tgttttttat tcctttcagg cagaagttgc aaacaatatt tttaatattt 95280 ttagaattct ttaccttcat tttcagtaaa tcccagttca aagttttgtg tgtgtgtgtt 95340 cccttcttcc tatcccaaat ttttactttt gtcaataaac ttacagtatt taatcatgag 95400 gcctggattc tcctgtcttg aagaaaggga cactcttgat atattttaat tttttaaagc 95460 atgcaggaaa gtcaatgctt agtgccaaga aaggacactg gatactggta ctttgaggac 95520 aatgacaatt ttttaaggaa tgtagttgaa acaggaaagg tgtactcagg agttctgtca 95580 atgtctaatc ttccaatatt acataaagcc agccctgagt ttagaacagt cacattttat 95640 ttatgaaagg ccttttaatc atctccttca gctgatgttc attcaattct tttgtaaccc 95700 tgatatttaa gagaattagg aagttttagt gacctaagga atttgaattt caaaagtgat 95760 tgaatctcat atgatattcg catacaaaga tctgttaaag actaacatgt aacgtctgtt 95820 ttcacctttg tttgtatact ttaaaaagtc agaaaatcgg ctgggtgcag tggctcgtgc 95880 ctgtaatccc agcactttgg gagtctgagg cggctggatc acctgaggtc aggagttcga 95940 gagcagcctg gccaacatgg tgaaacccca tctctactaa aaatacaaaa aaaattagcc 96000 gggcgtggtg gtgggcgcct gtaatcccag ctactcagga ggctgaggca ggagaagcgc 96060 ctgaacccag gaggcggagg ttgcagtgag ccaagatcgt gccactgcac ttcagcctgg 96120 gcaacaagag caaaactctg ccttaaaaaa aaaaaaaaag ccagaaaatc tacttgtata 96180 gtatgttaaa aattattcat gatatttgtt aaagattgta aggaagacat cactcaagag 96240 gaacctttat gatgaaggta ttgcagtaag gaagagagat agggctcagc tttgactaca 96300 gtgaggacaa gtgggcattt atagtcaagg aacagggcag ggattggcag taacatcaag 96360 gctaggggga ttcttgctag actggctcaa caggattctt gctgaaggca gataaatagt 96420 aggaaaaata aactgttttt ctctttctat attctaaaca cttgacatgt cacttctgat 96480 gccagatgtg tgggattttt cccacatcga ccagttatct gacatcagct gcatgttcta 96540 gaattcaatt cagttctgac accaactaga gtttatgcaa acctcccaca gattaacggc 96600 tcagtccttc aagaattcat tccaatttag agccagtagg tttccaggta cccacgattt 96660 gtccaacgtg gctacaaatt agacccctta cttgggtttg attatatgct agagtggatc 96720 acagaactca gtaaagtatc ttacttacta ttattagttt attataaaag gatacaactc 96780 aggaacagca agagatatgt agtgcaagct atgagggaaa ggtgtcagag ctgccattcc 96840 ctctcatggt gtacctcctt ccacctgttc agcaacctgg aaactttctg aaccccgtag 96900 ttcagaaagt tttacagagg cttgatcaca ggcatgattg attattaact gattctctag 96960 cccctcaatc tttcctggag aatgagagct ggggctgaac gtttcaagct tctgatcatg 97020 gcctggtcct tctagtgatc agctcccatt taggagccca ccaagagtta cttcattaga 97080 acaaaagata ctcctatcac ctaggaaatt caacagatta gaatatctat gtcagaaacc 97140 caggttaaag accatatatt agaacaaaag atacacctct caccagtatt gctcaggaag 97200 ttatgagagt tttaggagtt ctgcaccaga aaccagaggc agagaccaaa tatatattta 97260 ttatttgtta aaggaaaatt ttagacaaat taaatttgac agagtttatt tgagcaaaga 97320 atgattcatg aatcaggcag cagtcagaac cataagaagt tcggaaagat ccattttagc 97380 agtgtgagca atgggctttt acgagctgaa tgcaaaatca aattaaagaa atgacttgat 97440 tggctatagc taggcattta ccttatttgg gtatgatctg gtggaaagtt agaggttact 97500 tgccaggttc tgattggtaa agtctctagt tagaagttag ttgcagtttc taattggtaa 97560 tgtttaagtt ttgttttact gtttacattg aattggactt tggtttgatt atataggaac 97620 atacggcact ggagctgtct cagcctaatt gcctataaat tcaattcttt taaaagataa 97680 tatcatggaa cagcgtaata agatttagag ggtggggaat gaggaatgtg atcagatacc 97740 aaggatgagg gatttccact aaattgatta agccagattc ttgcttaaac tggactaagt 97800 gggtaaagaa cacagcccag ggtcagagcc cagtctagaa gaagatgtaa aggagcctga 97860 ctcggttttg gtcaaggaga gggtctttgt caagtataga gggcagagag actcaaagaa 97920 agtaaaaaat tagtacaact atatcctgta tatccaccac tcagaactga cagttgtcaa 97980 catcttgtca tatttgcttt aagtccttcg aaaggaaaag tcatcacata gaatcctttt 98040 ccccatttca ccagaatcct ctcttcctgc ttaaagatat cagttatggt atatttagtg 98100 tgtatctgtt gtgcaaactc tttggaatgt tagcttaaga caggcgtttc cttggcaaat 98160 ctatcccaaa tggcagctgt ttgtctgtac aaccaaatat ctaaatggac cattcagtac 98220 aatgattgct gtactttgta ccaaaatcct agaaatatat gaagtctttt cattacttta 98280 gtcctaaata aaatatactc atctcttcca agactccaga gcgaaaaggt ttgagtaaaa 98340 ggaaataaag ggggagggga gaagtgtgtg tatatattta tatagaatac atacaaaaca 98400 aaaattttcc atttccctgt cttctgtttc tttccataag tgctgttcaa ttaaattcaa 98460 attcggtttt ttgttttgtt ttgtttttga gacgggaagg tgtctcgctc tgtcgcccag 98520 gctggaatgc agtggcgcga tcttggctca ctgcaagctc cgcctcccgg gttcacgcca 98580 ttctcctgcc tcagcctcca gagtagctgg gactacaggc gcccgccacc gcacccggct 98640 aattttttgt attttagtag agacggggtt tcaccttctt agccaggata gtctcgatct 98700 cttgacctcg tgatctgccc gcctcggcct ccctgaaatt cagggttttt ttgcagttag 98760 gttatagcat tttcccctcc tctccattgc catcttctcc catcctgctc tcagcagcct 98820 gtgtgctaac acatagttca ggccaaatgt tttgtaactc cttcaaccac tttttgctcc 98880 ctaaaaccca actgactact ccatggactc agagcatcac catctgcagt ctattactcc 98940 catgtgaaag actgcagatg tccctatccc caggacactc tcaagcactc acagccccac 99000 taatactctg ttctctctca tctctcctcc ccagattaga ggattttcga gccattctac 99060 aaatgtcaga gtagctgtgg gggaagcaaa atctcaagca aaagtttctg ctagacgcag 99120 aagaaaagag gcctgttaaa tgagagaagg ggtgtttaca gagaaaggag cacctggggg 99180 agtgtttaca gatctggcct tctctgacca tgatgtatgc ctcagtcaca ccctcccttt 99240 gaaatttcca aagaatgaaa tactgctgcc tttttatata taggatgtgt ggtgattagc 99300 aaaacggaga cctctccatc atctgaaata aatctaaaac tattacaaac aaggctcatt 99360 atgcctccca acttgaatga tgggcattga tgctaatttt ggagggaagc accaggctac 99420 ctagagtagt cagtgttttt gtttagtttt ttactttgtc tattgtaaag tggtgtctta 99480 tcaacctctc ttttgtttgt gattacttta gaaaggaggc attcacggaa gcccggggtg 99540 cccgaagagg agttaaaaaa gtcatggtta ttgtgacaga tggagagtct catgacaatc 99600 atcgactgaa gaaggtcatc caagactgtg aagatgaaaa cattcaacgg ttttccatag 99660 ctgtaagtgt gttgccggag atattttcaa actcttaggt gtagagaaga gctgtgtgca 99720 tattgggtaa ttttatgaaa gtcacacaaa ccaggttgga aaagagaaag gtctccattt 99780 gaaggtaagc cctgggagga cagacttgga tcttgctccc tctgggtcct tagtacccag 99840 cacaatgcca ggccaaacag acactcaaca aacaatcatt gaaaggaagg aaggaaggaa 99900 gaaaataagg aaacatgaaa agaggaagaa ggaagcaaaa acataagaag gaaggaaggg 99960 tgagaaaaag aggactgaaa aaaagaagag gaaaagaaga ggaggaaagg aagggaagag 100020 ggtgggaagg cgggaaaaat gcctttgcct ttaaataaga gagaggattt gttcagtata 100080 acaagagcag tggccattgg gcttcccttc cccgtctgag caattttcga ctctcttttt 100140 cattaattat cttcccccat cacttagcta aagtggggga aagtgccagt tgtctctgtt 100200 taaatattaa caacttctga cgtttgacac ttgcttttca gcgaagtaga caggaattga 100260 atttttgttt tctgatgcaa tttataagct cctggtatag acctttcgac ctaaaatgta 100320 gacattctag tggggaacaa gttctgaaat aaaaagttac ccaaatggta tgccaattac 100380 ttcagagcta gctctagttt taacagtgtg cttcttcaaa acagcttgca gttcttctca 100440 gacattagtg cattactcct gtaacctcat tattcctata gcttcatgga acagcaggtg 100500 agggagctga gaaagaggca agggcaccca gtgacttggg tggtcccaga ggacaggggc 100560 aaagtggctt aaagtcctct gatgagacgt gtggtatttc ctctgggatg gtcactgata 100620 ctccccaggg aaaaggatga gggctttact gaagcaaaag aaaagaattg agaataaatc 100680 tgccactgcc ttctctctag taaggaacat tcaaaagcca ctgcactgcc ttcaagactc 100740 actttctcac attaacattg agtgtacatt atagtatttc agttgctgct ctaaactact 100800 atccattttt ttttttaaat ggagtctcgc tctgtcaccc aggctggagt gaagtggcac 100860 gatctcggct cactgcaacc tccaacctcc caggatcaag caattctcct gcctcagcct 100920 cccaagtagc tgggaccaca ggcgcacacc accacacttg gctaattttt ttatttttag 100980 tagagatggg gtttcaccat gttggtcggg ccggtcttga actactgacc tcaggggatc 101040 cacctgcctt gacctcccaa agtgctggga ttacaggcgt gagccaccgt gcccagccca 101100 ctatgcattt aatgatacaa ataaacaagt ctttcgtaga ttataaacag cagcacttta 101160 aacagtaatt ttagttcttt tctaactttc tataagtgaa aaatctgtat ccttcttaat 101220 caaactatca gttttttaat ctaccattct aaatctaact ttaaaaaact acatgtagat 101280 gtgcagtggg ggtgagctac tcagatgggt agggggagcc tcagacctgg aggaaagggg 101340 tgggggcagc cctcaagccc attgcccttg tgcccactat cctcccaggc cacagtgcag 101400 aaccatggtc ggaagggtgc ttgaggtctg ttttgtaaca ggactttgaa ggcagcacca 101460 tggagctctt cgtttttaat gatgccagac aaggctatta ttggaaaaag aaatgtgaag 101520 ccaaaaaatt cctgtacctt catggtcact ggaggccaag actctccttc ttcttagagg 101580 atttggatat tcttaaaaaa aaaaatcaag caatagcaaa gggctcagtg tctttccttt 101640 attttttgga ttccaggagc atagccttga attaatccga tccttgcttc gttcaggcca 101700 aattgtaatc atttgttgaa acaaacttta tttgtttctc tgtttagaac tatatctgtg 101760 tatttatttt aataatatta taagcatcca tggacctacc acccaaattg agagctagct 101820 ctcttttttg gtaactacat ctgagcacat ttaccacctg ccttcctcca cctgggtaac 101880 catcagtcca ctttctacat tcctcaacct ggctctactt ttcaaaataa tatttaggca 101940 cccatacata tccaaaaaaa taaattttaa gaatatttca ttgtttttaa cattttaaaa 102000 agagtgtaat gctgtatata atattttgga acttttaaaa cttaatacta tattaagatt 102060 catccataat gttgcatatc tgtatagttc attctgtttt taaaaattga agtgatattt 102120 acaatacagt gaaatgcaag gtttcagtgt gaaaagtgtg cacgaagtga acaatttggt 102180 gagttttgac aattacgtgc acccacataa gacttaatca agatatagag caatttcatc 102240 actcccagaa agtttcctgt gctttctttt ttaaaatgta tctttaattt ttatggatac 102300 acgatagctg tacatattta cctggtacat gtgatatttt gatacaggca tacagtggct 102360 aatgatcaaa tctgggcaat tggaatatcc atcacctcag acacttatca tttctttgtg 102420 ttgggaatat tccaaatctt ctcctgtagc tattttgaaa tatacaatat gtttactgta 102480 gttgtcctat agtgctactg aacactagct cttattcctt ccatctaatt atagttttaa 102540 atccattaac taacccctct tcatccctgc tcttccccac tactctttcc agcctttgat 102600 aaccaccatt ctattcagta tgtctatgag atccacattt tcagctcaca catttgagtg 102660 agaacgtagt gatatttgtc cttcagtgct tggcttattt catttaatat aatgttcttc 102720 agttccatcc atgttgctgg aaatgacaaa gttttgttct ttttaatgga taaataatat 102780 tctgttgtga agatatacca tgttttttta aatccattca tccattgatc catacttaag 102840 gttaattcta tatcttgtct attgtaaaca gtgctgcaat aaacagggga gtgcagatat 102900 ttcttcaata tactatttcc tttctttggg atatataccc agcaatgttt tttttttctt 102960 tttttttttt cattttaaat acacacctcc tgtagtaacc actgatgtga cataccacca 103020 tagctcactt agattgccaa ttcttgaatt tcaaataaat aaaactgtat agtatgtact 103080 gtgtgtttag cttttcactc aacataatta ttgcttgtga tattttgtgt actggggatt 103140 cattttttgt tattgttatc tattttatag accacaattt gtactctact gtttatagac 103200 attttgcttg tgtccagttt gagttattgt tataaatgta tcatgaacac taaaaaaaaa 103260 aaaaaaaaaa aaccaaagtg ataatcttca ggtaacactt gcaactatgg taaaaactaa 103320 tttttttatt tattacagaa gtgatttttt attataaagt tttaaaaaaa atattgaagc 103380 aaatataagg aaacacctag tgtcctaata tacagaaata caaaataata tattatgata 103440 cacatttttt cacatttttt atgcccatgt acttatgtga tttaaaaaat agaattaggt 103500 catatctaca tattggggat ttttaaattt ttttgcatgt taaattttac atattgtttt 103560 aaaaatgttt tcattatctt gaacattttt atattaaaaa cagttttaac ataaaaaatt 103620 tttacattaa aaactaattt ttttaggcag aaaaagtaca aacctcaaca aagctaatta 103680 gttggacttc atcaaaatgt aaaacttcta ctcttcagat gacactgttg agaatatgaa 103740 aagacaatct acagacggga agaaaacatc tgcaaaacac ataaaggact tgcatccaga 103800 ctatatacag aactcttaca acacatttaa gggaaaataa acatctcgtt ttcttttaat 103860 gggaaaaaga tttgaacaga cactaactac accgaggaag aaatactata gcaaataatt 103920 gtatgaaaga gtctcaacat cattagtcat tagagaaatg caaattaaat aagacaccac 103980 tatacgctaa cacaattgct aaaactaaca agtgaacaaa aaaaactgac aataacaagt 104040 attgacacgc atgcaaagca gctggatctc ttagacattt ctgatgggaa tagtaaaatg 104100 gcaaaatggg acgattactg tggaaagcag tttggcagtt tcttaaaaag ttaatcattc 104160 acttattgta tgacccagca ctttcatttc tagttattta ctcaagagaa aagaaaatat 104220 atgtctatta cagagaccta catgtgaata tttacagcag cattattcat aatatgttga 104280 agctgcaaac aactcaaatg ttctcattaa gtaaattgtg gtgcatccat acaatggaat 104340 gctactctgc aatagaaagg acccaactac tgctacatgc agcaacacgg atgactctga 104400 aaagcattgt acaaagtcac agaagccaga cacaaatggc tacatactat atgattcctt 104460 aaatctgaca ttctggaaaa atcaaagcta taaggacaga ttatttatcg gtggttgcca 104520 gggttgaacg aggggaggaa gggattgact ataggggcag gagggaactt tttggggtga 104580 tgtaaatatt ctacaccttg atgtggcagt aacacaacta tattggtttg tcacactcat 104640 agaattgtac atctaaacag ggtgaatttt actgtatata atttattgca ataaacctta 104700 ccttaaaaaa aaactaaatg tttgagaaaa cctgcttgga catctaaata attatagtta 104760 acaatcatat ataactcctg cttctctctc ctcttcataa aaaagaatgc ccctgtctcc 104820 agcatttggt ttcaaacaag aatatctcaa ttgtttattt tccagattgc caatttagat 104880 taccacttag tccagtatgt gtttaaaata tatatgtgct ggactgtgcc ttggtaatag 104940 tttcaggaag aattgctcat tcaaaagcag gcaactcact tgctgattgc ctttgccagc 105000 agataatgac atcactagct ggaataatat caaagacatt cagaaactat gaatataaca 105060 ttacttttga actgtcagat tttaaaaata cagctgttag taacagggac acagagtaca 105120 agaggagaaa ttttcacaga catacaaaat tgccctttat atttttctac accaattgtg 105180 gtgtttatat aacagttaat attagggagt ctacaaattt tgaaaatcac tcttccataa 105240 atatgaaagt acataaaaat tccattatgc taaggtactc tacactgttg tttactgaca 105300 aaatgcttga gatcctttat ttaacacata gaatttaaaa tatattcttg ctgtttctgt 105360 tgtgtcttag attcttggca gctataaccg aggaaattta agcactgaaa aatttgtgga 105420 ggaaataaaa tcaattgcaa gtgaacccac tgaaaagcat ttcttcaatg tctctgatga 105480 attggctcta gtcaccattg ttaaaactct gggagaaaga atatttgccc tggaaggtat 105540 gtctatttat cttattgctg catgttctct ctgcaattca aaatcagtat aatgggattt 105600 ttgtatttat tcctaataca tcagtaatac tttttttttt tttttactgt gtacaatatc 105660 tagcatggaa caatgctctt ttatataaat ctgccattaa gatggctgtt tctcacaaca 105720 ctgtgtctgc tagagactct ctttgtaagg gcatggtagg gcagtgctga tgggacagcc 105780 gatgaagaca atggtcaatg tagatgtgcc aggacaaaaa tgtttccatg tgctttgttc 105840 cttttctgtt acatagattt ggaaaatgag ggtactacct ctggtttggg ttttttttgt 105900 ttgtttgttt cttcatttca tattgagcta ctacaagagt gctcttatgc aataacttct 105960 ttgttcactt attttctctg tattttgctc cttgcccatt ttaaaggtct tcatggaaat 106020 ttgccttaaa atccatggca atgaaacatt ggttcactgt atttgtctaa atcatgttac 106080 ttctttgcag atttttcctt gagttttcaa tggtgactgg ctgttgagga taacgagtta 106140 tggcattccc tattctgcct taggtagagg atgtcaagta gctaattact ttggaactcg 106200 atctttccta aaaaacaaaa aaaaaaagtc ttcagaattg ttatgccagg caaactggca 106260 aagcttcttt cttcacattc tttgatgatc tctagtctca gggaacatgc gccttttctc 106320 caactaggga gagaaaccac cagagaattc ttttcccctt aggctacatc caaatccagt 106380 tgaccctgtc cttgtgagga cacactgaaa gactgttgtt tctacatctt aacaatagaa 106440 atttaaaagc actttctcag tttccctgat ttgattgata ataggaaaca gaaagacaaa 106500 atgggaatga gacacaactg aaaaaaagta gaccattttg attgagcgtc aaggggctgg 106560 gaaaatgcag aaaaattaga atatgaaaat gtacagaaag gaaagataat tatttagagt 106620 tatggctttc aaactttttt tgagtgtgac tcacgataat aactacattt tgctttttga 106680 cccagtgcac ataaatatat acatataaaa ataaggcaaa gtttcacaag ataattctta 106740 ttacatgtga tgcactgtga tggtttctca tcaattccat tctaccctaa tctctttcaa 106800 tgaaaaaaaa atgctggcta tactcagtct gttgatttca tgactgggtc acaatccgta 106860 cttagaacat ttgatttaga ggtgatagga atctacaggc cagccagact gaatttctgt 106920 gcctcccttt tcccctggcc tctttcccct gtgcctttag aaacagaaca ctctaattgt 106980 ttatgagtct ggagtcccag ctgcttctga agaactcagc tgtcttgtgc tctgtgtaca 107040 agtcattttt aagtggcttt ggtctctcaa cagctctccc ggtgtcattt accaataaac 107100 cagattatga gcttggctgg ccttaaggaa aatacataag gtcttccaac taattgtgta 107160 cttttaattt ttaataacat gggctaagat atgatagaaa caatctgtaa aaataattta 107220 aaagaaaagt tacatagtta catttgatag ttcaacagaa tacagtgtca tttctaaatc 107280 tccttttaag taagcaagta acctaaaact ggcaaaaatg aagcccactt cagctagggg 107340 agggggagat caattgcctg aaatgacatt tcagattatt tctaacctaa ctacaccatg 107400 gattaaaggt gacaggttga agagcccaaa cactccaaga agtctctata tttaaatatg 107460 acatcatttt ataaggaact ttacagatta caaatgtctt ctatatcatc tttgttgcta 107520 cactacacca aaagcagtgt tttgactaga ctatttctta tttttttcat gagatattta 107580 aaaaggcttt atttctttgt tgctcgggaa atctccattt cctgtcaaca tgtatcttaa 107640 gatgacaagt agctgtgatt atgaaatttc tgtttgccaa ggacagtgcc atctattgag 107700 gcaagtatgc caaggacttg cttagtacat cagaaaatag tctactgtct ccatttcccg 107760 ttgagcactg ggagaaaatg ccaacatttc taaccagagg ctgcacagtg gttagagtgg 107820 ctggcccaaa cacccatgaa cagtccaggg agaagtttga agcaagaagc ccaggagaat 107880 atagtggtct attaccatga tgccactgca gcaggaagaa catcacatag cgtccttctg 107940 tctgttctca gctgaaggca gaatagcggc agggcaggtg ctgaaaataa tgcaggtttc 108000 cgttgctgca ttcttattga tcttgcagat aagtgagaaa acacctgaaa gcattgtgga 108060 ctgaaaatac atgtttaaat taaagttaaa atgcatctca gtcatttaaa ttacagggca 108120 attcacacaa gagattaaaa tgatatattt gaattcttca ctgccgcgtc taatctagtc 108180 ctacaaaggt aattactgat gtatttgttc acaattttat ccatgtaaat aactaacaaa 108240 tagttacatt cacaaatttg attattctct tgcctcaacg aaagggcaga ctgactttct 108300 taagtgctat ttttaactta tctgcaaggc caaataaatc agtaacccct agtgcaagca 108360 aataaatcaa cattccatca attccctcag gaaattgtgg ctttgggttt gtgaatattt 108420 tgagaataat ttgagagtag cagactgcca tggaatgctc tgaattatct ctgcatttca 108480 gtaaagagct tcaaaatggg tacaggatct tttaaaaatg tatgattgaa tggcatgtgg 108540 gcagccctat cacaaagacc cctctggatc tgtgagtgat acttaccacc agtaattaga 108600 gcaaataaat gcatactaaa atacctaaac cctttatcac acaatgaaat tctgacagaa 108660 tctatggcct gaatatgggt gggactgatg gagttgagaa acctctttaa atatgtgaat 108720 gaaatttttt tcagtcccat aacatattaa gggagtttag cctaagggct cagcagggtt 108780 cccaaggcat gaatttggac aggaatttcc tactgtagta catccaactt gagccttgtg 108840 gacccaaagc accataggat ccacaacatg ctacagtata agaatggaga tttctcaacc 108900 cctctggcga ggacagggct gctaatgaac aagaatttga gacatgagcc ctttgactat 108960 ttttctctgt cttctaccca ggcctaccta gaaattttgg gttgagaaat gtatggctga 109020 aaatgcccta agatgtttga agttctggtt ggtaagacca caagctctac caggtatctg 109080 tattctgcaa gtcagtagtg catgaaaagg cattgttact tatttacagt gatattttcc 109140 tatgttatag ccacagctga ccagtcagca gcttcatttg aaatggaaat gtctcagact 109200 ggcttcagtg ctcattattc acaggtatgt tgaccagttg gtgaaaaatg aaatatatgt 109260 ttgcaagact tcccttccca aaccaacatc tagccatcag tatgtaagtg caacgtgcag 109320 ttcatagctt gaacaattat gcaggctatg atgatgtttt ctaattcaaa taggaaaata 109380 tcatttcaca agcttcttat taagaaaata tgttctctca cacagttcac tacattgtac 109440 taatagttgt gaatcagaca gtgtgagctt tgccttgtaa ttatgtatct gtctaaatga 109500 aataatttaa catatttgct acagatgtgg aatatttttc cacaggtcaa ggaattcaag 109560 ggtcttatta gaattccatg ttcaagacct aggatgctgg gcacccagaa taaagtagaa 109620 agacaagatt agaaaatata tcatttgcag ttaatgaaag aaaaggcata atggtccttg 109680 caaaagaata ttgacatttc catgtgcaat tttactgtat aacttgggta agttatttgt 109740 gccttgattt ccttttctgt aaaacaggta tggtagcaat agcatctaac tcatagagtt 109800 atcatgagga ttatataagc taacaaatgt aaagcacttt gaacagtata cctatacaca 109860 ttgttaatgg tgtttaagta tttcccctta ttatttttat taaatattat tatcttattt 109920 atttgcatgt aaggactggg tcatgcttgg agcagtagga gcctatgatt ggaatggaac 109980 agttgtcatg cagaaggcta gtcaaatcat aatccctcga aacacaacct ttaatgttga 110040 gtctaccaaa aagaatgaac cgcttgcttc ttatttaggt aaggtttgga tataattata 110100 aaagagttgt tttacttttc cattttttac ctttagcatt atttgcttat gtttctatag 110160 gcttgcaacc atatagcagg attatttcaa caagttgggt attttccaga acccatgcaa 110220 agttttaggc ctctgagcag ctttagttag tcaaaatgac atacatgggg gtcctttttt 110280 gttagtaggg ctgtctaatg cagggaatgg tttaggttga tatgtgccct ttctgatatg 110340 ttcagtttct ctgtgtctgg tatcaacttt aacttcaagg agaactttga acctggtgga 110400 caagaaatga gagtagaaaa ggaaacctcg acttctccta tatcctgaaa accaaactca 110460 tattgtctta aatgtcttct atcattaatt tctctctatg ggtcctaatt tgggaaaaga 110520 aaaatgtatt ttgtcatgta acttcttctt taatagctcc attcacaatc agacaaatat 110580 tgaacttaaa cccagtgata taacatgatc ttgtttccca gtgtcttgcc agaaatgagg 110640 agttgtatgt ctggtaccac tttatttggg atctatacca agctgagcaa cacctggggg 110700 atgccaggga actctcccct cactgaaaaa agatattcac caacagttgg gaggacctaa 110760 aataaaaagg accatcagga tatggcttcc cagctcttac tcactcaaca aatatttggg 110820 ggatcctctt ttgccccagg cattgatctt agtgctggga ataaagtgat aaagaaaaca 110880 cataccttgg cctggaagca ttcacagctt cacgtgttag ccttcctctc tgggatcttt 110940 ctgtcccgga gacaagtctt tttctctctg tcccagttgc tttctatttt atcaggaagg 111000 tggcaggtct ttactgcggt gtttatacat ctccttattg aaggacacct attaaagctg 111060 taggagcagc aggacttaag aagaataaaa ggactagagt tttagatgac taaaaatgta 111120 acagtcaaca gcagctgcac tgtgactgct aaaatctctt aagacatgta gaactgcatg 111180 aatgaaagtc cagtctgttt ctcatagaaa tcctgttaca ttccactctg gtcagacaac 111240 agctagagta tctggttgtt ctaagtatca catactacaa ggagaaaatg acaaactagg 111300 atgtgccagt aaaatattac acagaaaagt cagctcccga agcaattccc tgctacaagt 111360 ctcactctct cgaaaactta aagaaattga aggttagaaa acaaagtgtg cattgcatgt 111420 attttaggta tttggaggat tgtgatataa aatatagggg ttaggcttaa aattcatttc 111480 aaattttagc attaaaagag atcctatgga gcatgtagtc ttaatttcca atcaagaaac 111540 tgagagatag aacaattatg tcccagctgc ctatggcagg tgtgaaacca caattgaggc 111600 ttcttgattc ttatgtcagt gtttatatca cgataccaaa ataactgatt ctgggttgat 111660 taagaaagca ctgcacaaat attgagtacc agcaatgtgc caaacactga gtttataggg 111720 aataaaaaga tagatggggc aggtcagttc ctacactgat aaaccttact tttttgggtg 111780 agagacaata atgaaacaag caatcactat cagtatgata tgtgctatga cacagaatac 111840 ctaaaaaaga gggctgggga ttagattaga tatcttctaa aagttcatta catcctaagg 111900 ttctatgaga ctgtttatgt gaaatacctt ggaatcaaga accagcttaa cctgaggctt 111960 ctgttatatg tagaataaat atagaacatt tatcttccta tataatggat gacatataaa 112020 ttagtaaaac tccttatgaa aggcatttga caatgtgttt acagagctat aaaaaatgtt 112080 cgtaccacat ttatacagaa atttcacttc tgtggaccta acctagggaa aaaaatccaa 112140 tatttaagaa tgccaagtga acaatgattt ccattgtatt attatttatg ttattggggg 112200 aaatgccatt atcctaaatg cccgaaaata tgcaggtagt taagtaaata gtaaatccac 112260 ttaatgaata ttacacaccc ataaaaataa aaattataaa gctgctgatt ctatgatact 112320 aaagacttga agcagttatg gtacaaggtg tacaattagc gatagcgatg aggtcataga 112380 gacttgagct tgttttctga ttctgcccct ggctatggct ttaggcaaat tactctcccc 112440 ctcaaagcct caattttcct atttctaaaa tggaaataat tacaccatat atatcatttg 112500 ggttgttaga ttaagtaatg actatattta gtactgtgcc tgacacacag ttaacactca 112560 atgggtgttg tctattattt tattatgtaa atgttattat gtattttttt attgtgtaat 112620 gttatataat aaacattcct cttattagta ttgtggtagg cagaataatg atccccaaag 112680 atgtccatgt cctaatccct ggacccatac tttgcatggc aaaagggact tttcagatat 112740 gatgaaatta aggatcccga gttggaagat tatcctcaga tatctggctg gacctgatac 112800 aatcaagcat tctaaaaatc agagaacctc tcctggatgt ggccagaggg agacagaact 112860 atggaaaaat ggtcagagag atgcagtgtt gttggcttta aagatggagg ggggccacaa 112920 gccaaaaact gtagatggct ctagagctac aaagggcaag aaaaccgatt ctccttgata 112980 ggctcccgaa aggaacactg acctgccaat atcctgatgt ttagtccagg aagctctatg 113040 ccagacttct aataaacaga atggtaagat aaaaagttca tgatgcttta agccaccaac 113100 ttgtggtaat ttgttacagc agcagtagaa aactcataca taatacaaaa taataatagt 113160 agctgacatt agtactatta ctaataagta ttgagtattt acaaatttaa agacactgtg 113220 tgaagtccac aaagatgtgt atgatattgt tgccactctt aggaagccca cacattttaa 113280 ttgataacac tgtagttttt ggtattctta attatatgtg attaaattcc tttaaagtaa 113340 ataaactctt aagaatccta aatttgtcat tcccaaaaac ctttggttaa acgttgctta 113400 aagcagatgt ggagaattca acttaaagat gccactgcaa gtaagaaaat attaagaatc 113460 ttatttctga gcacagtatt tataatatat gacttctctc tgtccaaaaa ggaaattttt 113520 gggtatgttt tctacagtgt gctgagattt tcttttctgt ttcagaaatt atttcattag 113580 cttactcaca agtgagggta tatgacattt tgccaacata aagtctaata catgtaagat 113640 ttctttcaaa atagaaaagc attcagaaaa ggcaggacaa ataccttgtg ttttttttca 113700 cccaaaataa tattctaaat ctgaaatgaa gttttcaaaa tgtttctttg tgggggtcac 113760 aaattgagaa gagactgagt gtattttttc ataaactgtg tggattgcaa gttgtaaggc 113820 tatgaaaaat cttatgaagg aagcagaggc agaggctctg ttagaaaaat cccatgctta 113880 tcaataagga tcaggaaact gtaagaactc aagctgtcaa acatctgtct caggacatag 113940 tcctacccca tctttctatt acccaaactg ccttatgcca atacaggcat tgcaagtgaa 114000 tttggtggtg aaaatacagc tgggattatg ttcccctgcc tcctccaccc acagtttgct 114060 gaattctatt cctgccatac agcttccaaa ggagaaggaa agatgtgagg caatgtcatg 114120 gcatcaagac agatcatacc tgtttcccat tacctcacta gatcctggcc cttttcccaa 114180 gaagtgaatt atgagagctg acagaattca ttcttcataa atccatgcaa agggctatgc 114240 catccatttt agcctttttt tcctcttttt tttttctctt tatttgagac agagtttctc 114300 tcttattgcc caggctggag tgcagtggca tgatctctgc tcactgcaac ctccacctcc 114360 tgggttcaag tgattctcct gcctcagcct cctgagtaac tgggattaca ggcgcctgct 114420 accatccccg gctaattttt tatatttttg gtagagaccg ggtttcatca tgttggccag 114480 actggtctcg aactcctgac ctcaggtgat ccacctgcct cggattccca aagtgctggg 114540 attacaggca tgcaccaccg cgcccagccc ttttcttcca tcttattctt ttctttttca 114600 ggaaacacta ttaagcttaa atatttataa ttattttcct tcttttaaaa ttaggcttta 114660 cttggctctg gctctctttt tcttttcttc tttcttgtct ttagacaccc aagcctcaat 114720 tagtaactac gctaactggt agttactgtc cctgagatta tttcagctaa tatttttagt 114780 tatcaagtat aagtcatcaa agagagttaa ctaaataatc tcacaactcc tagcctcaaa 114840 cataattttt aactcatttt taaaggaggc cttttatcaa gttacattca cagctctgca 114900 aattacacac acacacacac acacacaaac acacacgtac taacactctc attctactcc 114960 cttctttata tttcttagca gagtggcatg aaataaaaca gccttcattt tgcacattct 115020 tcttttccat tttatgtatg tataaacatg gcctgaaaga ttcattttaa aacaatattg 115080 tggttagtaa tacaaacatg taacacatta catgttcgaa aaaatatttt agattctatt 115140 atgtataata ataaaaaacc ctcaaagaaa gatgaaggaa tgagaatgtg aggaatattc 115200 ataaaggata atatgcctga ggaatagtgt tcctttagca cttgtaagaa taaacatact 115260 gtataaaaac ttttgttcct ttttaacatt tttgaaagaa agtcaaacct actttacagt 115320 aaaatacttg gtaagtgagt tagaaaaatg atctttttct cagtgagaag tgctattctg 115380 tggcattttg aaaaataatc ttacttctgc tccactgaag aaatctggtt attaaaagag 115440 ttattccttt tataaaatca aaatctgcat gtggcaattt ttattcattg atatggctct 115500 cttctcaaaa cacaaagaac aaatctaact tttcactcaa aaattaatct taaagacaca 115560 atttatgctc ttcctgtaag cagcctgaga tgatctctta aaatggttta ctattcactt 115620 gacccagaac aacccaaaaa atcattcaaa tcaagagatt gaaatcttcg tgttcacttt 115680 aagaacatcc atgaagctac ccaggcaatc aagggttatg tatatctgaa aagccaccaa 115740 gtatctgaaa gatgtgactt tacagaagca gtgtgtgccg ttccatcatt gcaatggtgg 115800 agctggtaga tgtgtccaaa gccaaaccgt ggagctggac agagggttta tggccccaaa 115860 agagtgctga aagtttgttg cacatgcata caaatgtaaa aagcagtgct gatcttaaag 115920 gtttgtatgt agagtctctt gatcattgtg tacatctagg tgggcgaagc acccaagata 115980 cactggctct gtttacaggg ctcatggtca gattaaccca tacgtgacct ccacccccac 116040 tatcgcaccc accgcactga aatgatgctt actgaaatag aacaaatttt tctaagccag 116100 aggaggaggt tgcatagaag aaaaaggtat tccagaagaa accgaagaaa caaaaataat 116160 gacccaggaa taatttcaat ataaaatata tgcaaataaa atcaaaagta gaaaaaagac 116220 aatcaaaatt ttaaagagca tggaagctca attaaaatag aggagagaac cgggcacaat 116280 ggctcacgcc tgtaatccca gcacttcggg aggctgaggc gagtgcatca ggaggtcagg 116340 agattgagac catcctggct aacacggtga aaccccgtct tactaaaaat acaaaaaatt 116400 agccaggcgt ggtggcgggc gcctgtagtc ccagctactc gggaggctga ggcaggagaa 116460 tggcgtgaac ccgggaggcg gagcttgcag tgagccgaga tcgcgccact gcactccaac 116520 ctggacaaca gagcaagact ccatctcaaa aaaaaaaaaa aaaggaggaa agatcagata 116580 cgtgaaaaat gattcaagct ctgtgttgaa taaagtcaca ttaaaatcac agaaaggtac 116640 tgttgttaga caatgtttaa cacctattaa aacatacaca aatttaaata atagtgatga 116700 tacacaaagc ctgggacagt ttcatgaaat tgtctttcat atggcggttc atagaacaaa 116760 gtagtacaaa ttttctggaa acaattttct agacactata agaaccatta aaaacgtgat 116820 ccagtgatct attccttgaa atgtactgtc aaaaaatcca gaagagggac aaatttaaat 116880 gctccaaggt gtctttgaaa tctgaagcat aataccaaaa atattaaaac cacctgaatt 116940 ctagtgtttt atcgggaaat ggccatgtaa tataaatgca atgtctttat gctttaacca 117000 agagaaatca tcttcaatta tttaaaatta caattttaaa agctagtagc agcacagaaa 117060 aggtttacat tttctatgat tccaattata tgaaaagtgt taatttctgt agtgcagaca 117120 catatatcca aatgaaatac aattgattta ttacaaattg gggtggggat gtgcaatttt 117180 ttatgtgtgt catcattgtt atatcatttg tgattttaaa taatgaaaaa ctcagattgg 117240 gggaaaataa cttctcagga gaaagcagtt gtggtagata gagagcatat taaaagcttc 117300 caccaaaaca aattcttacg tgcattgaag aaaaaatatt attttcaaaa tataaccata 117360 taaaaatgat tatcttggcc atttaaaaag agtcttaatt tattacatga agcctttaag 117420 ggtccaggtg gtatacctgg aatctttctt ttgttaggtt acactgtaaa ctctgctact 117480 gcttcttctg gagatgtgct ctatattgct ggacagcctc ggtacaatca tacaggccag 117540 gtcattatct acaggatgga agatggaaac atcaaaattc tccagacgct cagtggagaa 117600 caggtaaact tgaaaaatat tcttttattt aaattaatct attcatactc tatgtatatt 117660 tactgtctat tgtcctaaac ttaaaaatgc aatacccaca tattcagtaa caactgggaa 117720 cagggccctg tgttaggttc tttggaagga tgtatagtgt ctgtatcttt gtcttcatgt 117780 tggatgggtg tggaggtaag atatacaata gatgtggata cagatgtaca aatatataca 117840 caagaaaaga gatccaaaac attaagaggc atgaaattac cagtggccca gacaatacag 117900 tcagaatatg atgggattgc tttaagctag gattggtgca gaaaagctta ttagaagatg 117960 aaattcgggc tgaatctaca agggatgata gaatgtggat aggtagaaag agcagtgaaa 118020 gagaaagtta aaaagataac atggacccat atgatgtgag gttttgaatg gcaaattaag 118080 agcttggatt ttatcctgga ggtaatggga aattgtctgt aatatttaaa attgaaaaat 118140 tcttattagg tagtattgaa tattaaaaga agtttgggaa atgatacatg aaataacatt 118200 tacatatgta tatataaaaa ctgaaagaaa catcgtaaat atgcaaacat ttacacacac 118260 acatattaac tgaaagaaag atctaacatg ctttttgttg ttgttatttt tgaattgtga 118320 tagcttggga acttttgttt ctaaaaagtt ttctgtattt ttcaacagtt ctacaaggag 118380 gatttattaa ctttattcca cagtcctttt acagagggtg ggagaggggt tcttcttagc 118440 cttcactaaa tattccaact ctctagacta gaggggcagg actgcatcag ccctcctgct 118500 ctgcaagagt ccaagctgca gcccagcgca gcagtaaagc tcaggtgcag ggatactcac 118560 attaggcagg tccacaaact gcactcgctt taaagcccca tgccctgcag gagcagtatc 118620 ttttatgaca acaccataga catagcttcc agggtgtcta caaagggcag gccggctaca 118680 agagtaactg cactctggga agtcaaaaat atgtcatctt catcaggtac ttataattca 118740 tttatagttc cacacagcct gaatacaata ttccagtaag aggttatttt tacccctgtc 118800 agcgttgctt agccttagtg gtaaagttga aatcccagcc acagcagatt cccagggcaa 118860 cagagttaga gtagctaaag gtcagctcct caagtatcag gtgaaagggt tttattaact 118920 ctttgcccac atttacgctt ggaaaacgca taacagttag aaaaaggcta ttgttgtagc 118980 tcaaactgga ggtaagagaa cgtaaaataa gatgtcagca gtaaaaatgg aaaaggaagg 119040 gccatgacag atatcaataa taggaagttg acaatagtaa aatgaagcat tttagatgac 119100 gtctttgatc cattatcact ccattaattg tatacaagac aagaagtgtc aaattttatg 119160 aaaatttgca tatgaaagtt gaggagagta tcatgaatga tttaaatcgt gaatgatttc 119220 agtttcaagc ctgggaatct gaaagaaagg tggctccatg attagaatgt caacacctca 119280 agcaatttag atatttttta acaatgacgt ttggctttta gacatgttcc ttgtaacagt 119340 aagcacaaat tcagatattt gaaggtgcca gtaaagtaaa atcaaaatag gtaaagtcaa 119400 tgagtaaagc tgctgggcaa aaaaacacag gaagtggtgg gaaccatggc cctgggcagc 119460 ttgtgagctt ccactgagct ccagttgacg gttgccatgt ggggaggaaa gcccagagtt 119520 gcaagatctt ctattttatt tatgtttata attaattcaa cttttaaaaa aacctctcaa 119580 ggccctcaaa agcctgtgag aaaagtgcat tcaaaagtca gtgtcttttg cccacatgcc 119640 tagaagcaat gtctaggact gtagaactga agccttgaga aggaagacag aatgatgttt 119700 gcaattgcct tagtagaaat ttttaagaag gattggtcat ctagggtaag agaatggaaa 119760 aaggctacag gtctgagctt tagaagaggc caaaattcag aaaatgagag ttggggaaga 119820 agccagtaaa tatgaaaagg gtggtctatg ccacaggggc agaagcaaga gagtaagagt 119880 aaaattgcag aagccagtac agggagatgt accataagat aattgttaag agcatcaaat 119940 attaaacata gaataatatt tgaaaaaatt aagcatttag gtaatgaagt ataagttctc 120000 tgcttttctc taaacagatt tctatcttta aatgagaaaa catattgcta caagggatga 120060 tacccctgca atccttccat atttttctat gtcccatagc tgctgggata aggcttaacc 120120 atttcattga gaagacaatc ttccaagact atgaggtgaa atatgccaca ccagtattcc 120180 aggacaactc agctccttat aatgtattta aacatatatt cagccattgc agcatgcatt 120240 ctactgctta tctaatttta tttccttaaa aaatcactat agtattactg accttttctg 120300 atttgtggag aagaaagaga ggttagagtg aaatctaaag aaattcattt tgttactgtc 120360 aagcgatgaa atctgtaaca gctgttcatc ctcaaagatg gaaccgactg atattcttta 120420 tcctcatgaa agagccaata aataactttc agggagcatc aatttttatc tttcatttcc 120480 tttgccaact agctcctctt ctagattgct agaagtaaaa caaatgtaga tttcagtttc 120540 cttgagaatt tctgttgttc attgggctgt tttgtttcat tttgtgtcct agattggttc 120600 ctactttggc agtattttaa caacaactga cattgacaag gattctaata ctgacattct 120660 tctagtcgga gcccctatgt acatgggaac agagaaggag gagcaaggaa aagtgtatgt 120720 gtatgctctc aatcaggtaa tggtgtctga gtttggtaga aatccaggaa aatctcttcc 120780 ttctcttcat tttttaataa taaattccaa tttttcactc actttgaaaa aacagagcaa 120840 agaagctatc aggattcatt cactccacca acccctcagt tttgaaatga ccatttataa 120900 ttctaataaa gtagctccaa ctcttagata ttttctgctt ggaaatgtga attatgttta 120960 acaatatata ggataaagga ggtaaatata aatctcacta aactgctaaa taaacccaca 121020 aggcttattt aggctgggag gcttatcagc tctggcttgg agatagataa taacctcagc 121080 agttaaatcg gatagggtgg agggggagaa gtcatgagtt tcaaggcagc aacactgcag 121140 gcttccagga aatacttcac tgggctggag tgagattttg tcttctgttc ctgactttag 121200 acatcatttt ttaagttaaa taatttttaa tttcttcatt agaagagtgt tttgctcttt 121260 atagcaaagc cagtgtttat ctatttagct tttccaaata tgtacattct ctcctaaatt 121320 gattatttta aataataaat catgtgtctt tcttcctatc attttttggc ttcctcctgt 121380 caactttttt tgtcctgggc tgttttgtcc tttttccaag aaagtgtatt cttgattacc 121440 tttgctagta ctttctgtct gggttttttt tttttttcct tccactctag gcagctttag 121500 agaaagtttc ctttctgagc agaataaatt ttcgctttgc acaatattgg gtgaagaagg 121560 gatagtggca caaattaagg atataatatt atttggcctg aaaaagatgc tctgaattgt 121620 atactcaatt gcattaaaaa gagattccat taaagtatgt ctcccacact tctaccatct 121680 gctctttgga atccctaact ttactctcag ataggcacac tttttaagaa attttaccaa 121740 ctttaccact aatgtacaaa tggctgttaa tagcactgat ttagtatact ttaaaaattc 121800 tactctgctg tagtaatgat ggaaatacat aaatatcctg tttatctttc ttccagacaa 121860 ggtttgaata tcaaatgagc ctggaaccta ttaagcagac gtgctgttca tctcggcagc 121920 acaattcatg cacaacagaa aacaaaaatg agccatgcgg ggctcgtttt ggaactgcaa 121980 ttgctgctgt aaaagacctc aatcttgatg gatttaatga catcgtgata ggagctccgc 122040 tggaagatga tcacggggga gctgtgtaca tttatcatgg aagtggcaag actataagga 122100 aagagtatgc acaagtaaga attgaaacct acagattccc acccttcagt gataagtcgg 122160 ttcaatgcca ggcattacct gtctaacttc atgagttatt taatttcttc ctcctgacct 122220 tattgggaaa ctggatttaa ttctctttaa gtgtttttta tagattagtt actatatata 122280 tatacacaca caaacaaact ataaatatac acatagtatg tatatagtat atatagtgta 122340 tatataatgt gtatatagta tatatatata cacactatat atactatata cacactatat 122400 actatatatg gtatatatag tgtgtatata gtatgtatag tgttccttat agattaatta 122460 ctatatatac acactatata tacaaatagt ataaatatat agtatatata gtgtatatgt 122520 agtgtgcata tggtatatat agtgtatata tacacactat atatagtata tatggtatgt 122580 atactatata tagtatatac ggtatgtata ctatatatag tatatatggt atgtatactg 122640 tatatagtat atacactata tatactatat atagtatgta tactatatat agtatgtata 122700 ctgtatatac tatatatagt atgtatactg tatatactat atatactata catagtgtat 122760 atagtgtata tatagtatat atagtgtata tatagtgtat atatagtata tagtgtatat 122820 atagtttata tattgtatat agtgtatata tagtgtatat agagtacata ttgtatatat 122880 agtgtacata tagtatatat aatatatagt gtatatatag tatatgtagt gtatatatag 122940 tatatacagt gtatatatag tatatgtagt gtatatatag tatatacagt gtatatatag 123000 tatatagtgt atatatagtg tatatagtgt atatatagta tatagtgtat atatagtgta 123060 tatagtgagt atatagtata tatagtgtat atatagtata tagtgtatat acactatata 123120 gatactatat atagtataga tacactatat atagtgtatc tagtatatag atacactata 123180 tatagtatat atagtagata cactatatat agtatatata tctatatatt agatacatat 123240 actatatata gtgtatctac tatatatact atatatatag tgtatctact atatatacta 123300 tatatatagt gtatctacta tatatactat atatagtgta tctactatat atactataca 123360 tatagtgtat ctactatata tactatacat atagtgtatc tactatatat actatacata 123420 tagtgtatct actatatata ctatacatat agtgtatcta ctatatatac tatatatata 123480 gtgtatctac tatatatact atatatggtg tatctactat atatactata tatggtgtat 123540 ctatatacac acactatata tagtatatag atacactata tatagcatat ctaatatata 123600 gatatatata ttatatatat agtgtatcta ctatatatac tatatatact atatatagtg 123660 tatctactat atatactata tgtatagtgt gtatctacta tatatactat atgtatagtg 123720 tgtatctact atatatacta tatatggtgt acctatatac acacactata tatagtatat 123780 agatacacta tatatagcgt atctagtata tagatacact atatatagcg tatctagtat 123840 atagatatgc tatatatagc gtatctagta tatagatacg ctatatatag tgtatctagt 123900 atatagatat gatatatata ctgtatctag tgtatctaca atatatatta tatatagtgt 123960 atctactata tactatatat attatctata tactatatat ctactatata ctatatattt 124020 catatatagt gtatccagta tatgtattat atatagtgta tccagtatat gtattatata 124080 tagtgtatcc agtgtatgta ttatatatag tgtatccact ataggtatta tatatagtgt 124140 atccactata ggtattatat atagtgtatc cagtatatgt attatatata gtgtatccac 124200 tataggtatt atatatagtg tatccactat aggtattata tatagtgtat ccactatagg 124260 tattatatat agtgtatcca ctataggtat tatatatagt gtatccacta tatattatat 124320 atagtgtatc tatatactag atacactata tatagtgtat ctataaacta tatatagtgt 124380 gtgtatatag atacactata tatatagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatat 124440 atatatatat tttttttttg agacggagtc tcgctctgtc gcccaggcta gactgcagtg 124500 gcacgatctc agcttactgc acgctccacc tcccaggttc acaccattct cctgctttag 124560 tctcccgagg aactgggact acaggctccc gccaccacgc ccggctaatt ttttgcattt 124620 ttagtagaga cggggtttca ccgtgttagc caggatggtt ttgatctcct gacttcgtga 124680 tccgcccacc tcggcctccc aaagtgttgg gattacaggc gtgagccacc gtgcctggcc 124740 gtaattactt tatattttat acatttatct agtttccttt ctgttgttat tttccatatc 124800 tccaggattt gactttttga aacagttaaa aaaaagaata ctttgtaaca atgctgttta 124860 acatctgtta aatttagaat gggacattta gtgtgtcccg ttctaaatag agggcactgc 124920 tttctgaata aggcaaaaat aattgtatga cttaaccaat aaaggaaatt agattcttga 124980 ttttatattt aatgtccatg ctgttataat aaattgcatt aaatttatat ttatccatta 125040 agttgatata ttttcgtcaa gtgaattacg atttctaaag gtttataatt ttctcgcaag 125100 taatccttag aaaaaataaa tctgaatatt aagtttaagc tgcagggaac ttctgttatt 125160 cctgtttgta atttgttgtc agttaacagc tctaatccat aagtgtattt tttttccttc 125220 attagaaaaa taacaagtta caaaagtgct taatgcacta cactataaaa acaaaagaat 125280 ttaaaggagt ttgaatgtaa ttgtctgctc tcaagtaatc atagttggtt agatattgaa 125340 caactactta caaataaaac agaattcact accttctagc ttatataatt tgaaaagaaa 125400 ttagaatatt aattatttca ttttctattt gagtgttctc tttggttctg tagtcaacag 125460 agctctcaaa atctattcat gtaatgcaaa catgagtgat ttttcataaa accataatga 125520 caatagtgaa cagaataaag ggcttatttc aataagagca cttgtatcca tttgataaat 125580 aatttgtttc tgttgaaaat ctttatggca ttatttactt aacaagagac aggcaatatt 125640 aatgactggg gcatgatgga attaggaaat gcaggaagag agttctttct tatattctaa 125700 tactttattc cttcagcatc aatcctgtaa atttaatggg gtagcatttg aagtagaaaa 125760 ggaaagctaa atcattgtca gatgaaatag atttgtcata aacaacttgt tttctaaatg 125820 gtggtaaatc aagatgcaac tttaaacaaa aacaacaaaa agaatattag agttggattt 125880 gtttaattac tggcaaaatg tttttccaag gaataggtga agatgtgctt actcatttcc 125940 atgagaacca gagatgctgc ttatgtatgg gataatccag aatcaatcaa gcccatagaa 126000 ccaaggagtc agatatctcc tgaattcttc acttaaaaaa atgaggagga ttgctgggtg 126060 cggtggctca tgcctgtaat cccagcactt tgggaggccg aggcaggcgg atcatgaggc 126120 caggagttcg agaccagcct ggccaatggt gaaaccccgt ctctactaaa aatacaaaaa 126180 attagccggg catggtggcg cgcacctgta atcccagcta ttcgggaggc agaggcagga 126240 gaatcacttg aacctgggaa gtgaaggttg cagtgagccg agatagcgtc tcaaaaaaaa 126300 aaaggggggg aaatactttc aaacgagcct cacctgttta aggatgaaaa atgtttccat 126360 ttggtttgcc ttagtaggct tcttatttta tgttatttat gtggaaaaca agaggctcag 126420 aagacttgaa gtttagggag ggtttgtaag tcctgactgc ttgccatggg cttctgttaa 126480 aagcattagc ttaagcttga accaatgcta agtcaggaag tacagatatc aaacatacta 126540 tgtatggtaa tgtgcacaga tcagtcttca agacatactc atttgtgcca tctcaacgtt 126600 gtgaatacat ctgagtggaa ttgagtctct tgtgccctca acttttagga caatttttga 126660 aagacagtag agattacata ttggaaaatg tatttgatgg gatgtgttat ttatacccag 126720 ccacaaagtt cagtgaactc caaattgacc cctaggacaa tattatactc ccctcccccc 126780 tttgctgata tgatatgttt tcaagatttc cagtaccttt agatatgtct gtgtgatggg 126840 attggctagg aagcagaaag cacagaacca attactcata ctgtttcctt tgaggattag 126900 acacaatgac actatataat ttttccctct ctctggtgtc agtgaccttg taatgatttt 126960 gtctgtacta taaaaacagc aatatcctct gggaacatct gagtatttcc tcttatctcc 127020 acatgaggga cctcttgggc ggattcccaa attaacaaaa ctgattattt tgttaaacaa 127080 tttaaattct cagatttatt tgaaactgtt ttgaacagac tcttctcata tgaaactctt 127140 ttttttggat tctcacagcg tattccatca ggtggggatg gtaagacact gaaatttttt 127200 ggccagtcta tccacggaga aatggattta aatggtgacg gtctgacaga tgtgactatt 127260 gggggccttg gtggtgctgc cctcttctgg tatgtatttt aataacatcc tgttaatctg 127320 agactgggtc acttgcagag ctcccagtgt gattggagct catgtcatac caaatatcta 127380 tttccttttg tgttccacta tgcaaataca agttattcag ttgagtgagc tggaagagtc 127440 aatacatctt aagaacaaag aagctatatg aaagaaacaa gtagaatgaa ctcttaattt 127500 ggtgtgtcta ttatgtggtt tacactaaaa taggtattct gttttaggag aggtataggg 127560 gaagagaaga tcttatagag gatgtatata aacaagaaaa tatccctaat atttggttgc 127620 ttacaaggtt ttagagataa tcgactttgt attcatttac ctgatacata gaaacagata 127680 atcgcgtagc actctctgac tctgtttata ttgttggtca agcctagagg catcttaagt 127740 aatatcttcg ctcagccttt aaaatgccta aatccccaaa ttggcccagt tctttcagat 127800 acatacattc ataatgcttt attaattatg aataaataat aatttagtag gcaaaaataa 127860 ttattgctta ctaaatatcc tatctcaaaa actaaatatc ctatttcaaa aactgttctg 127920 tttgaaagaa attactagga agtcaagaat caacttaatg agaaatccac atgataattt 127980 tgaaaaatat ataataaatt tcattaagaa atataaagga agggtttcat aaataaaatc 128040 tatttatgcc aggtgacttt atgggaagtc cgcatgttga ttctcctaaa ttaatgcatt 128100 ggtttactgt aattcgggtg gaaacataca tcaatgctct ttttcccaaa aatctaccta 128160 gaagagtaat aaagtataaa agaaaggtga agatagagag gtgaaaatag atgactttgc 128220 tataatttaa gataatgctt aagaactaat ggtcaaatta aaatggtaca gtaaattgtg 128280 cacatacaat aatcactatt taaaaaaaaa acctttacaa tagaggggaa agaagactga 128340 agggtgatac ctaagaaaag ggaatattag gcagcacagt ggctgggact ttggggagga 128400 ctcaccagaa gccaaggctc aaaaccagaa gtcagcagtg tcagggacaa tggatatact 128460 tcaattttgt ttgaaatgtt aatcctgaat tagtttatta tgctcccttt agctcacaaa 128520 tatttattgt attaattctc atattaaaaa tatgttttca gggtttttat gctccagttt 128580 tgtttcaagg ctttcttgca aagctttgca aacttattta tggcctctcc tgccccaaat 128640 caaggcattg atggcccaaa atgatagtca tttccctatc atagtccagg ctccactgac 128700 agcagaatgg accaaaccga tatactggga cacgaagact aagattcaca atgcctaaca 128760 agaagtgaga gtggatacaa gtgacagatg ataggaaaaa cgtttggaag caaatagtga 128820 gagtcttgtc atgagacctg gactgactcc caagaaagat ctggctgggg cagagaggat 128880 gtgtggggtg gacaatggtc gaggcagctt catgcctgga gaatccatat tactaagcag 128940 gaaactaggc atgttcattc attgctgatg aaagggtaaa ctggctaaaa ctcattcgaa 129000 ggtctttatc aataagtgtt taaaagcatt ccaatgttcc tactttttac caaggattta 129060 acttcctaaa aatgtaaaga tacaatctag aagtacaatt aaaggtgtca tcacagcact 129120 gtatgtaata ccatctttta ataatgttaa atttaccact atactcagaa accttttttt 129180 taaattaagc taaatatcca atgagatggg attgaatgca tagattatgg tatgtgcata 129240 tgctggtata gtctgcttcc attaaaaata ataaatccca ttaaaaataa tgttctcaga 129300 aaaatgtaaa tattggaaag ctgttcattg taatataatg ttttaaaaat ttgtaggcat 129360 acatatgaag atgtgctttt gtatatatgt atgtatgcat gtgtgtacgt gtatgcatgt 129420 tttcttctgt aaagaaaaaa ccactgagtg tactaaatgt taatgatgat tattgctgag 129480 tggtagtata acaagttatt tgtgttttct ttatgcattt ctatgatgtt tatattttct 129540 atgagtccat tgttttaaca gaaaaaagaa aaccaccttt ttttaatgca aaagcataag 129600 tagtgacctc attattcaca acatacacag ttataagggg ctagctctgg ccacaaggca 129660 gaaaccaggt aaaaatgtgc agtaattgtt ccggcttgga tctaagacaa tgacctcagt 129720 atccatatat tctccatgtc tgagatctta ctctgatctc attttggatt agtagacatt 129780 actgggcttt cgagttaaaa cgactgagtt taaaatccca ggtttttcct cttaatagct 129840 tttgacctgg cataaaatat ttaacttttc agagccccag ttatcaaacg taaaacaaaa 129900 aaatgatgtt gcttataatt aaccttaaga attaaatgaa atagcatcca tgtctagcac 129960 aatgcctcaa atgttatttt gcttttcctt cctagaaata gaggaagagc tgaactcaca 130020 aggacagaca atattacagt ccagacaaga gatagcaggg gtctacgggc tgttcaggga 130080 cctttagact tctttcaaat ttggaacaaa ctcgtaaatc cccaaaatac agttgattct 130140 ggggtttcac ctggacactt gattccatct cttttccatc acaggaaaaa ctagatcttt 130200 ggtgtttgaa ccaaaagccc caaatggttt ccaaatataa cctacatgtc ttagaacatc 130260 agatataatc tcttctgtaa caatgattaa ttaaagaaat ggagtcctga gcgctgtatt 130320 atacatgaag cagaaccctc ttccatgcac tcactttgca ctcccaagtt gatgacattc 130380 attaaatgta aaaatgtgtg agtaatccca ttgtttttgt ttgtaggtcc cgagatgtgg 130440 ccgtagttaa agtgaccatg aattttgagc caaataaagt gaatattcaa aagaaaaact 130500 gccatatgga gggaaaggaa acagtatgca taaatgctac agtgtgtttt gatgtgaaat 130560 taaagtctaa agaagacacg atttatgaag ctggtaagca aaataattat agcaagtact 130620 tttgggtaga ggacaatata tttgctctag catgatgaag tccagtagga tattgtattt 130680 tccccacatg gtgagctgca cgtcatattt gccccagtga agatgcagaa ccttgaaaaa 130740 aaattctgtt gcaaaaggaa taggttatgg aacccagtca attctggagc agaaattaca 130800 tgtttgtatg cagtgccctc aacactccat agtttctgtc tggctctcct acttgctatg 130860 tacaatgaga cgcttaagaa aaaaataccg attcagaggt agagtttaga aattgagcta 130920 caaatgggcc cagttttcct tcctgtaggt ttctaccatg actcttctct cccttctctt 130980 gccccctctt gggaaagact gatattgcag agaaccctaa tactttacca ttcccacatt 131040 tccgagatcc tttgttccat tgaggtgacc ctagtttccg agagtcagac ttgttctgtg 131100 tgtgtgttct caggtgcatc aggtcagcct gtgcttcctc ttcctccctc cgttctccac 131160 tttctaaggc agctttttaa tgatgttgaa atatgctcga atcaaagcta taaaggccat 131220 tggctaaaga agagaaattt actctgtaac caaatacaag cagaatgaga aaagccatta 131280 atccttaaaa tctgtttttc ttgatttgtt ccatatgtgc atgtatatgc tctgaaatag 131340 cctcctgact agaaagatca atgaggtata agaacataaa ataatgattt tgagttttat 131400 atgtaacttt atttcagtct tatttaattt ttgcaaagta attaagtgat caaataagga 131460 atattgtagc cttcatatac agtgtaagat ttcatttatt ttctttattg tggtatgctt 131520 attttattga accttaatag tggtttgacc ataagctgag ataatgtcat tttatatata 131580 aatagattaa aatgtatata tttgtaaata aataactaaa gtatattttt gtccctattg 131640 aaatataaca taatcaatat tctaagcagg gttccaacat ttctaaactt aaaaagaatg 131700 ttttaagtga aaatataata aatacagtgg tggcctggca attagatgat aggcaggtgt 131760 gcatgtgtgt ataagaatta taaacaataa atgtaattag acactgaaag cacagtgaac 131820 tcagagacca gttctataga gttcctcaag gttatcttca tgactgctaa tatcattgtt 131880 ataacagtgt ggatatgctg aacaatagaa tcttttttga ttgattgcca aagagatttt 131940 tctataatgc taatttaata atctgtacaa tatgagaatc acttcaaata aacatttcca 132000 tcaattattt tttaaaattt ttgtagattt gcagtaccgt gtcaccctag attcactaag 132060 acaaatatca cgaagttttt tctctggaac tcaagagaga aaggttcaaa ggaacatcac 132120 agttcgaaaa tcagaatgca ctaagcactc cttctacatg ttggcaagta aatcatatat 132180 cgttgctgcc ttattccaaa tcaagaatac agtagagatg tcttatttca agtcaatcaa 132240 attcttactg ttttatttca aaatgcactt atgatgtcat aaaggaaatc ttgtttgttc 132300 atttttatca taaaatcgca ggtctaattt tctcatttcc aaatatttgt aaaactatct 132360 ctagtcttcc ctgtctgcat tatcagacat ccatatatta tggaacggca ggaaaagaca 132420 cagtgttcta gttgacaaga aaccttattc atgtcttcat ttctttcact cattcattta 132480 ttccttcaac ttgaaaacat ttaatttctg tgggccttgt ctgtcagttg tggttggtaa 132540 gtgattaact gctctggggg cagactgctg ggctgtatgc tttctgggat ccatgtaact 132600 acatatctcg ccgtttgatt ttagagcgaa ggggaaaatt atctggtatt ttctatcatc 132660 tgtaggcttt gtgctacttc agtttttttt ttttttaatt ttagtggatg agggagtttt 132720 ggaaatcaaa ctattaatgt ttagagatgg ctggtaagcc agtgtgaatc atttaaaatg 132780 tattttgttg ggacactgtg tatatgggga atgttcccaa cagagggcag gagtttccta 132840 aacattttct taaaatgtac atgagagtga taaaaacaag aagcagcatg aaggtaatga 132900 ggaaactgat tttagtaact gacattaaga cttagagact tgacggtaaa cttggagctt 132960 taaaggaacc aggccaattt tcctacttct gacttatttc tgtattattg atatattcat 133020 agtctgtatt ttgaaaattg tagttcaggg gcaggggagt gacagaaaat gtgcaccctt 133080 ttgtgccaca tttgttcttc ctcagtgatt ttcatgttga tatgcttcat gatacttatc 133140 atgaagctta ttctgtcagg accaagatca atctattatt tggtaaaata acactggagt 133200 tgcccctcct atttagttaa tcagaactga acacttagga attagaatgt ggataaaatt 133260 tgaatgggta tgaaaccaga tatggcattg tctccaacct gctaaaaatc atctcagtct 133320 atgtttgtcc acaaattcag tgtctaagtt atgtccaggt actggtgttt aaaggactga 133380 aatattttca aaatttcgaa aattgttttg gattttgaaa gaagcacttt gaaatttgtt 133440 ctggagtcag ccagtgtaga atttgtatcc caaatattcc acattctgag agactttggc 133500 aacgtcgttt ggtctcttag agggtcaatc tttcatctgt aaaataagga caataatagt 133560 tactcatctt agaggactgt tgaaataatt tgcaataatg tatataaagc tcataatttt 133620 gaatactata aatgattatt gttattggtg gcatgttaac agtattaatc atattcacat 133680 cctttccaaa taattttaca ttataaaatt cttggccagg catggtggct cacgcctgta 133740 atcccagcac tttgggaggc tgaggtgagt ggatcacctg aggtcaggag ttcgagacca 133800 gcctggccaa cgtggtgaaa ccccgtctct actaaaaaca caaaaattag ctgggtgtgg 133860 tggcacatgc ctgtaatccc agctagtcgg gaggctgagg caggagaatc acttgaacct 133920 gggaagtgga ggttgcagtg agccgagatc gtgccgctgt actccagcct gggtgacaga 133980 gagagactct gtctcaaaca aacaaacaaa caaacaaaca aacaaaaact tatagctgta 134040 ggtatatatt atattaatga aatgtaactc attttataga aagtttgccc ttctgaagtt 134100 gggaaatgtt cccggaagtg ttacataatg atctttggct tgaggtctca agaaaaacta 134160 tattgtgatg caggtagctc ctatgttgac acagccaagt gtgatgttgc catcactcca 134220 gcagggccct ctgaggaact ggaagtgagt caacaggtca tactctgaaa cctccacatt 134280 cccctatgcc ccttgtcaga atgccaatcc ctctccaggg aagcaaaagc ctgatgagat 134340 catatgtcag attagatgca caagaatgct gcagtaagcc tgacccttgg gaacagaaga 134400 aggagacata acaagatcag aacacccggt aaatatgata ccagtgatat attttatgtt 134460 tcaccctcta ggacaagcat gactttcagg actctgtgag aataacgttg gactttaatc 134520 ttaccgatcc agaaaatggg cctgttcttg atgattctct accaaactca gtacatgaat 134580 atgtaagtca gatttcttta aaatacaaaa taccaacttg tgaacatttt aatgtcacta 134640 gtaaactgtg ttttttcact actctgcatt gatcacaaag aacgaacaac taactggaag 134700 aaagaaaaaa aaggcaagca gattttattc ctggtcagga atggagaaag agggagctct 134760 tgctctaaag accttctctt caagctgtga aaacctgggg aattttaagg agttagatgt 134820 ggggcaggga ggtatatgta agcatgtcca gagaggaact ccagatgtac aagtacagct 134880 cataaacatg cttccttata caacatatgt tcaagaaatg gtggccattt tcttctatgg 134940 cagggacttt agcattataa tgacatgtta atgatctaaa ggtaacaagg ggttgctggt 135000 tcttgtttgc tccgttttct caatggcttt atcttcctct ggtaattggc aaagggtcct 135060 gaagctccca ggccgtctat agttgttttt cagcaagctt acctacagat aaatagacta 135120 gaaaaaaaaa aactgtttaa gaaaaaataa tgcactttct cagctatcta ctgtttaaca 135180 aaataatgaa ctttctcagt tatctactct tcaagaaaat agtaaacttt ctcagccata 135240 tctccaggtt tgccctggta acattaggaa aaagcttgaa acccatgcac acataaccct 135300 aaatcaattt aaaatgtttt aaaaaagaat taggctcttc tagacttttt ccaatccttc 135360 taatttccta ttgttggagt ttaagaaaac taataaatga cactcatttt tacctcattt 135420 gaatttagga ccaatggaaa gaaatctccc ccattattct aataagcact ggattgcagt 135480 gtatggttta ggtataaagg gtgtcctcac gctgaagcat ggacttagac caccagtaac 135540 cacctaggtc atcagcagtg ctgatccatc tctgtccttc ttcatggagc ccaccttgta 135600 aaacttgtca aatggagtag agccaaatgt gtgcttcctg tgggtacagc tgctctgaga 135660 atagaaatga gagaaaggga ctgagttgtg ttcacttagt tcctgttccc aaagttagag 135720 tccatgtgcc acccctgaga gtggagtgag gggagagaag agggagggtg tcactagcgt 135780 ggctccaatg gaagagatat gagggatggg gaattctttt tccccataca cctatcttcc 135840 attctccctt ccttcctacc agatatattg attgtcttat acataccagg cattggagct 135900 tacagtctaa cactggaaac aggtattaag tagtaattag agcatatgct atggaggagg 135960 atttcagagc tctctaggaa cttccaccta ggctgagaag tcaggacagc cctcctgaag 136020 ttgtgccatt tcagtggagc cctgaaggat agggtgattt ccaccctatt taggggagtt 136080 tggggagcag aggggatgct aagtgtgaaa gtcctgagca tgaaggaaac aacgacattc 136140 gctagtgtgg ctgacgctaa agagcaagaa aggaggtgac gtgaggtgag gccggaggta 136200 aaggcagggg ccgggtcatt cgggacttgg tgccactgca caaattctaa acttttgaaa 136260 gagcagtgca gtgcttttga aggtttttat ttggttcagc cacacgacag gatgcagcag 136320 agtgaagagt ggttggaggg aaacaggtgg atgtgggagc cccgtgggaa gctattactt 136380 tagttcaggg aggaaatgag aatgcttggg tgtgaggtgg tggtgggact gcagaagcaa 136440 gaaaggattg gagagatatt tagaagagga gtagaatgga cagggcttgg tgagttacat 136500 atggtggtgg tggagaggcg gtcaatgaag aagaatcaag caaaactcct agatttgtgg 136560 cttgaccgtt ttccaccctc tcaactgagc tttatgatat tcctaagtat ttgattaatt 136620 ttaagagaaa aatctcatga ttagagttga gtagatttag atcttgcagt acttgacttt 136680 gtatttcaaa actgtccttc cctggcagac aaaagccagt gcaaagcacc catgaaaatt 136740 gtgcgttctt aaaaggacaa gcacaattta catttgtaag taaatgttta ctcttctccc 136800 ctataaatta cagggataaa tataaaatcc cttaagattt ttgcagggaa attctcctta 136860 tgagttgctt aacttacttt ggctgtatgc catttttgtt acacaaattg atgggtaatt 136920 ttcaacaatg cgtagctaaa ttttgaaaaa ttctttcctg tcatcatttc agattccctt 136980 tgccaaagat tgtggaaata aggaaaaatg tatctcagac ctcagcctgc atgtcgccac 137040 cactgaaaag gacctgctga ttgtccgatc ccagaatgat aagttcaacg ttagcctcac 137100 agtcaaaaat acaaaggaca gtgcctataa caccaggaca atagtgcatt attctccaaa 137160 tctagttttt tcaggaattg aggtaaactt ccagtttttc atttatttgt tctcttaaca 137220 tcatttacct ggcctacttt tcatgctact gagataattg cttttattag attgattttg 137280 aaagaataga aggaattttt tacattagtc ctcaccaatg gtgaaagtat taagcttttt 137340 aaaaaagttt tgctttattt attcaaatat gtatgtcttt tcttagattc tgtgtgagaa 137400 aaggatagct catgtataaa aactgtgtgt ttcataaaat ccttaaacca ctgaaactga 137460 aacagagtca aggaaaataa taacaatcaa agccaaaaca gttaacagac gtacagagag 137520 gtacctctgt gttaagcaaa aaaaatttac ctgcaggaaa atcaagatac catatctccc 137580 tttctatgca aaatccttac tttggcaaga tatttgtatt aaataactgt gtcttattga 137640 tttgtaacag aggtttcttt tattacattg gcaataaaat atattaatct gtgtaagatg 137700 ctatatcaga ggtaatcagt gtttccaaat gtgaactttg ctcttaattc tgatctccaa 137760 atgaatccca ctgagttaaa attttgtgta tatttatatt aattaatatt acatacaatt 137820 tatattaaaa gcaatgcact tattaatatt atacatagta ttaaaacact attgtctact 137880 ttctgtaaac tcagatttca tggacgtttc tctctatctg ttaggatatc acttagagac 137940 atgatgacta agacaaacct aaaaataatg tcatatatta ctatattttg gattcaacta 138000 agaatattaa ttacaggctg ggcatggtgg ctcatgcctg taatcccagc actttgggag 138060 accgaggcgg gcaaatcacg gggtcaggag atcgagacca tccaggctaa cacggtgaaa 138120 ccccctctct actaaaaata caaaaaatta gcaaggcatg gtggcacaca cctgtagtcc 138180 cagctactca ggaggctgag gcaggagaat cacttgaacc cgggaggtgg aggttgcagt 138240 gagccgagat tgcaccactg cactccagcc tggtgacaga gggagaacaa gactctgtct 138300 caaaaaatta ttattattat tattattata aatacaaatg tacaaagtaa tcttggggaa 138360 aatattacca cagaattttt ctctagtaaa aattattgcc tgtatcctcc tatgctgact 138420 taatggcctg gcagagaggc atagctaaaa aatctgacag tgcatctctt ctgtgtatat 138480 taacagtaac aacagtaata atgatggcaa ccatttcttg agtcacatca tggtttaggc 138540 cctgtactaa ggatttcact tatttcattt tcattaattc ttttgtaagt aggtatgact 138600 gtactgcaga gatgcgaaga taaaaccttt ttttcatgtt tcaacattct tgtaattgca 138660 ttttacaatt gataacatgt ttatttacgt ggcagtgtta tttttacttc ttatgggtat 138720 gtaaaaataa tggcatatct catgttcaat ggcattttaa actggaaaaa atagagtata 138780 tgactaaacc acttgataga aaatcagtcc cagagaggtg aggaatctta acaaggataa 138840 agctaacagt ggtgcagtca gggtttaaat tctggtggtc acgggtcaga gcctatgctc 138900 ttatccactg cactaaactc ctccaatgac tagcattcac tgaagactgc tctgcaccag 138960 tcttgggtgt ctggattatt ttatccagcc accgcaatca ctctgtgagg gaggtgctat 139020 tagtacttcc attttacaac tgaaaactta ggtaggattg tgagatatgc tttgtctttc 139080 aggcacccac aagtgatgtt ttaggatttc catgagtgta gaacagctgg tcccagaatt 139140 ctgtgcctct tccagctaaa tcgagacaaa aatagtggca aggcagtcac caagacacat 139200 ctgggaaaat tctgaaagaa cacgtatcaa tatttcacct gcttgtccac tctgattctg 139260 tttgctttct cttcctaggc tatccaaaaa gacagttgtg aatctaatca taatatcaca 139320 tgtaaagttg gatatccctt cctgagaaga ggagagatgg tgagcagatc atacaaaata 139380 catgtagaaa ttgaatatga aaagtaatat gtgcaaagac aaatatataa atccttccaa 139440 tggtagttta ggataatacg gatgaaaaat gttcagttca aaattgtgac agattggaat 139500 atgctatggt cagaatgttt gtgccccacc aaaattcata tgttaatact taatccccaa 139560 tgtgatcgta gtaaaagatg aggcctttag gaggtcagta ggtccagagg gtggagcccc 139620 catgagggat tagtgtcctc atacgagagg cttgagggag actgctcacc ccttctacca 139680 tgtcagaaca catagcaggt gccatctatg agaactgggt gtttccagac actgaatctg 139740 ttggtgcctt gatcttggac ttcccaaccc tcagaactgt gagcaatata tttctgttat 139800 ttataaaatg cttggtataa ggtattttgt acaaggtatt tataaataac agaaacatat 139860 ttaacaacct tgtaacaatt cttacacagg caaactcgaa caccaagaca agatttaaaa 139920 tttatactac ataacatatc taatttatac tacataacat atctgataaa atggagctgg 139980 gaaattctgt tattggagtc tcctaggtag taggtgtctc tggccttcaa gaaaaagaat 140040 gcttcaaata gattggttta gaacttaatc agaaattctc cttccatctc tctctttcta 140100 aaaaaaaatt gccttattga gatataattc acgtagcatg gagttcactc gttgaaagtg 140160 tgtatttcag tgggttttag tatattcacc aaattataaa ttgtacagtc attacgacaa 140220 ttgattttag aacattttca cacaccacaa agaagccacg tatgcattgg cagtcactct 140280 gtttttcctc aacagccttt ctcccaagcc caggcaacca ctaacctgct ttctttttct 140340 atggaacaaa ttgaatttcc aaatatcaat tgacttttat tggcaattct agaatcaggc 140400 aacaccttat tctgtaaaat aaaatgaatg gtggatgagc tgaggagagg aagttgactt 140460 tatagagaga aaagggctga agaaagcaga aacagaacga aaagttgatt ggtcatttca 140520 aagttatttt ccttgtaaaa gtgaaagcag aggggatttt cttatcatgc tgtttgaaac 140580 tggcttgatt ggggatttgg tgattatctc tcacttttct catctcccaa aaagtcagac 140640 aaatgactta atttcggctt tgtggtgtgg aacttaagca ttatttagtc tgttgggcct 140700 agagcaagag ctgtccaaac caatgacctc ctatatgttt tacttaacat gtttcttagt 140760 ctattctggc tgctataact aaatactata aactgagtag cttaaaagcc agaagtttat 140820 ttctcacagt tctggaagct gggaagtcca aagtaaacac actggtagat ctagtgtctg 140880 gtgagggccc atttcatgct tcatagaaga tgtcttttca atgcatcctg agatagcaga 140940 accaggaagg cagcattctg agttacaagg gtactaatcc cactcatgag ggctctgccc 141000 ttatgatctc atcacctgcc caaaggcccc atctcctaat atcatcacat tagtgtttag 141060 gtttcaacac atgaattttg aggggaaaca ttcacattat agcaatatgt aaaacatggt 141120 agacattcac attgaaaaag aatatgtata ttatatgtta ttctatctat tttgagatac 141180 aataaggttt cattttgtaa gacaatgttt ctcaaataac ttcataattt gagtttaggt 141240 aatgtcattt atggaaattg aatattttag tcaaagtaaa tttcttatct gttactaaag 141300 acatattttt attttatagg taactttcaa aatattgttt cagtttaaca catcctatct 141360 catggaaaat gtgaccattt atttaagtgc aacaaggttg gtttacatgt gtataaatgt 141420 atgtatatga atgtatattg cttcttctgt gtatgtcgaa tattttgctc tataaactca 141480 ctgacagttt cttccaggtt gtaggagatc agtagaagtg gaaggcaatt aaccactttg 141540 cttcacaaaa acacccttaa gaataattag caaaataaag aaattttcat ttaatagaaa 141600 taattcacct agattaaagc aatggttcta tgagctatag aagataccat aatcacacat 141660 catttatatc tgccaaattg catttaaatt cataaaaaat ttactgataa tttaaaaact 141720 ttcactggct gcccatcaag gtcaaatgaa tcattagatg gacttaaagt tttatgatat 141780 ccttttgtaa tttaatatac tttattcaaa tcagtcagta cttctgaaag gtatcataga 141840 acacacagac taacaacagc aaaggctcaa taaggaaagt gaaatagtgg tctaactttc 141900 ttctaattgt aattatccac tgacctgtct gcagtgagat ggtgtctttt actgttttat 141960 tcacagtgac tagcattgtg cctgccatat tataatcact acatagatgt agacgaaatg 142020 aataaattag agaaatgaat taatggatta attaattctg tatgttcaag tcaactcaac 142080 aaatatttat ttgacatcta ttatgcacaa gatattgagt tagtcactgt aaggaatata 142140 aaaattacta agggcatgaa actcctcata gggtaagtat tacagtaggg ggttgagtct 142200 agtataaaat tattgtaacc tgggatagaa taaaaacact ccattataga gatagaaagc 142260 tttgtcagaa aattaataga agctgaaata atatctactt ggcaatggga acccaagaaa 142320 gctttatcaa ggaacttata attgagaaag accttgaagg gtagatagca tttcacagag 142380 aggtcactga atagcaccag gtggagcatt tcaggcaaaa tatatagctt gattaaaaag 142440 gttatcaatt ttagctgaaa tataaagaat acataaagta gcaatgaaaa taaacaggga 142500 gtgtgcattc tatcatatta cgctaggtac tgaatgtcag tcaaggtatt atttcttaat 142560 tgaacagacc ttgaaaagcc agtaaagttt ttgagaggta aagtcatctg tacagagctg 142620 ctgcttatgg agatgaattt aggaaggctg cagtgtggaa tgggtgagag aaaaggggac 142680 cattcatgct aagagctgag tcacacaaat acctataatc caaggcagca tgctgctttc 142740 tctgtcctgc tgcttatgag ccactttata catttgggaa taagcagagc cattaaaaag 142800 tactcttatg cccattctgt gagacaatat gttaggtgct tggtcagttg gtggaggggt 142860 atgtgtaaaa taataatgaa agctaacact tactgaatat ttcctatgtc ctaggcacaa 142920 tcttaagcac tttatactta ttactaattt aatcatcatt tattactcat ttgatatccc 142980 attttataga tgaagaaacc aaaacaaaga cagataagta atttgaccaa agtgtatcag 143040 tgtccaagaa caatctcatt ctctggcccc agagccagtg ttcattactc gttatatcat 143100 ttgtatgtgt tttctaatac gaggaagtat gtatatgtgt gtatgcacat atatacatgt 143160 gtttacataa tatataattt aaatgataac caaaatcaag agaataaatc agtgtttaac 143220 aaacaatatg atcatcaagt acttagtatg gaaagactat taaagaagaa aacaaaagat 143280 tttagattta ctctcagctg tgtgacccta atcacttatc tttactaagt cctcatctgt 143340 gataaataag catcacctgg gggcagatat gtggttaaaa acagaaattc ctgcacccca 143400 agttggaacc cctaaatcca tatttctaag ggaagcccag taacctttgt attttaacaa 143460 ttaaactgag ggattcttat caatattgtc atagaatttt gaaaaacata aatcagtgtg 143520 attgtcaagt ctagtcgcac atcagaatca acttgggaac tttcaaccat accaatcatc 143580 tctgatctcc ttcttcaccc caattaaaaa aatgattaaa aattatactc ttacatgctt 143640 ttatttagtt gccaggataa gcttctcttt caaacactta gaaatgtctt taaatagtca 143700 agattttaat ggtttgtctg aatgtgccgt gtattttcta gtgacagcga agaacctcct 143760 gaaacccttt ctgataatgt agtaaacatt tctatcccgg taaaatatga agttggacta 143820 cagttttaca ggtaggagaa aactacattt ttatgtggat gcctttctat taacccagtg 143880 gttctgaaag tgtggtccct gcctggccaa gggcatcagc atcacctgga aacttgttag 143940 gcaaattctc tggccccacc agaaacctac caaatcagaa actcggagga tggggttaaa 144000 caagccttcc aggtaattct catgcatcct aatgtttgag aaccattata ctaaataacc 144060 caaagtgtta ggtgttagtg ataccggatt gcatttgctg tccagtctta attcccgaat 144120 gcaagttgaa gacccagaag tccttcgcaa aacacgatat tttcttagag gccgccagca 144180 tatttcttgg tcatcgttct catcctgtgg aagctgatca gtcttctcaa tctggacaca 144240 caagattaaa gcatttctca ttgataagag ctgtttattt cttccaccat tcataaacca 144300 ttctttctct taagaacttc ttatctatcc caacacaaac catgttgaca aactttccct 144360 ctataatttc ccctgcttaa gcagaactcc aagcttttgc caaataaaca tgtgcaatat 144420 acttaaaagg ataagaatca gtggcaagta ggtttattct aaaagtctta tcattttatt 144480 aattttttaa taatagtggc taacatttat tgagcctttg tgttctgtct tatgtgatcc 144540 tcatgataac actatggttc aaatacaact actatctcca ttttccagtt gaagaatttg 144600 aggttcagag aggctaattt acccaaggtt atatattcag gaagtgttag tttaaaccat 144660 ttcacatgct tttttttttc ttttaattta aaaactgttt taaattgaca cgtaataatt 144720 gtacatattt ataaggcgct tggagacgtt gtgatgcaag taatatatag caactaaaca 144780 gggtaattgg aacatccatt gtctcaaaca tttatctttt ttttgtattg ggaacattca 144840 atatcttctt tctggcttaa taatttatta tctatggcac tctctcttta ctaaatggag 144900 actacaaaaa tggcatgatt ataggacata catgtagatt gtgctaatat ttctcagcct 144960 ttaaattctg tctccacttt tctgtatttt tctgtatcca cttctattgg tgcactgact 145020 tttccccaag agttttccat ttacttaaaa tcaaattttg gcaaacactt ataaatattt 145080 tttgtcttcc cttgactgaa gtgctgctta aaaacatact attttactct accaagttca 145140 tccaaagaac atgatgaagc tgtgtagaga agattgaact tttaagttta gcagtaaata 145200 taggacttta aattatgaaa tggtaaaaat ttttaatcta tttagaattc agcattacat 145260 tttagtttca tttttcacta ggtataaatg gtattagtga atttacagaa acttttcact 145320 tgttaaccat gaaattttaa cttttaaaac tcatattcta gcattttggg gtcaaataag 145380 catcagtgac tattgaacta aattacataa tccttctcac tctcctcaaa gatttaattt 145440 tacgtttcaa ggtaaatgaa ttcccctatg atttgaaatc cctacaagta tttttgtgga 145500 attacatgat atggagaaag aaaataatga ggccaaataa aagttaaact ttgttatgtt 145560 ttatttttct tctaattaat tttttaagct ctgcaagtga ataccacatt tcaattgctg 145620 ccaatgagac agtccctgaa gttattaatt ctactgagga cattggaaat gaaattaata 145680 tcttctactt ggtaagaaat tacctctaaa atagtattct aaaggagtta tttgtaaata 145740 tataaattaa agtattaaca gacacataaa aatatgttgc ttcaatgttt aatctctata 145800 ttccagcata ttttctttat aatttcataa atataaatat agacatataa tatataaata 145860 taattttcaa tttatatttt tctttataat ttcactgaag atttaaattt gttgtaatta 145920 tattttcaca tcagtttaga gatctaagcc tctaatttcc tcaaaataag ataccactag 145980 aatgactttc tagaaaaaaa aaataaacta tgggactaga tagatgctac cgataaacct 146040 gtagacttta cttacattat tttatcagtg tgactgagaa aagcactttt tcattaatta 146100 tgactatatc agaaatttgt tatcacaatt gtcttggcaa ttttttttac ttaacaaata 146160 agtatgtatc acattctcct tattgttacc tttcacatgc attgtactat aaattactca 146220 tgttggtact accacctcct taaatgatgt tttctattac atttattttt ccttttaaat 146280 ccttcataac aaactctata ccactatagc aaacaatcac ggaattttat tttaggtaat 146340 gcctagttac tgacacagac tcaagttaaa atcactcaag gaaaaaagag agcacaattc 146400 aaataatgga tttaaatatg tattcaaaaa tatgagataa tgcaacaaaa ttataaatga 146460 agacagcctc aatccttttg ggaattgcca accacaaaaa aaagttctct catagagtat 146520 aaataaacgt atactcccaa gattaatttc attttttaaa atttgtactc tttgctagaa 146580 ttcctatgac aatttatgct aatttccctg gaaattagca taaatgccaa tcactctact 146640 ggattctagg acagattttt ggaattcagg ctatcagatt tctccagccc tattcacttt 146700 ccctgaacta gaaaattcag caaaaaaaga aagaaaacaa aaagactttg ttgcagaact 146760 ttatatattg taacttatta gggtccagat ttgaaatagg tactctctct tataaaagtg 146820 ttgatatgaa ttacattgct aagaatattc ctgagcataa aactttgtgt gtatctctga 146880 ttattttgct gaagtaaatt ctagaattgg aataaaggag ttttttaaaa gaactttttt 146940 taaggtgaaa cccggtaagt ttactgctcg gaattttccc taggaaattt ttggtgatag 147000 aaacaaagat ttcagggatg ttcttaacaa tattatttat aatagtttaa aaattaaagc 147060 ctgggcacaa tctaaacact taacacaatg aaattactta cattatcata tatttagtga 147120 agagattatc atatattcaa tggagagaca acgtaatatt ttagaaggca cattttggag 147180 taagaaacca taatgctgct atttactagc tttgtgatct tggaagttct taattttcat 147240 tccaaccttc ttacctcata gataaaacaa agataatatg aggatctgct tcctgcagtt 147300 gttaacaggg ttaaaagcaa taatgcatat aagaagatta gcacagcatg tggcacatag 147360 tcaacaatat tgatattgtg gttgttatga acagtcatat tctcaataaa cttatacatt 147420 taaaggaaaa tgccatagca taatacattt tacagacagg gtacaaaact gtattttatt 147480 gtgttacaaa ttttataaat atgcatatat gcaaatagga caggtaacct acactaaaat 147540 gttaccaagg tagttgaagt ataggaaacg tttattttca gtattttcca atgtttctac 147600 aaggaacatt ttttaatcag aaaaaaatgg taattacaga acacaggatt tctttttttt 147660 tttttttttt tttttttttt ttttttttga gacggagtct cgctctgtcg cccaggctgg 147720 agtgcagtgg cgggatctcg gctcactgca agctccgcct cccgggttca cgccattctc 147780 ctgcctcagc ctcccaagta gctgggacca caggcgcccg ccactacgcc cggctaattt 147840 tttgtatttt ttagtagaga cggggtttca ccgttttagc cgggatggtc tcgatctcct 147900 gacctcgtga tccgcccgcc tcggcctccc aaagtgctgg gattacaggc gtgagccacc 147960 gcgcccggcc agaacacagg atttctaact gaatatcagg aaacagaatt tgactggaaa 148020 tcaagaagat aagagttagg gagcatgttt aagggtccag gtgcagctgg tcaggaacct 148080 ccagaattcc agaattaaag gatgtatttc gtctttacaa acccaggaaa ctgcttcaga 148140 tctgaggagc tctcagtctg gaaggctcag ttgggtagat cactggcttt ccttgggtct 148200 atctatgtag atcaaggcgt tccctaccca gctaaagaag ctgcacaggg atgccatagg 148260 tttcaggcct gcagattatg cttcagcagt aggaagggga caactgcatc tggttgtccc 148320 agttcagttg taccttttaa gcagggaagg acctctggat agtgagttca gtttcctgtt 148380 gaactttatc ctgcccacct ttccctctga gctacactca ctactggtag cagaacatga 148440 tactaagtgg aaactttggg ttagtggata aaatcgaatg gagactgaga tgaaagtaaa 148500 tctgactctc ataaaaccag attatcaaca gccagtgtca cggtagccct agctgggggt 148560 agaattgtga agggaagcag atgggagtct ggttttcctg tatagtggtg gcagatccca 148620 tctagccagg attagagatg atttatgggt ttaaggaatt atggcaaact gggtaaaggc 148680 aaccaaaaat ctaaattgtt ccgtggtctc ccttctttcc agtttcaaaa agactggtat 148740 gttaaaaaaa aaaaaaagaa agaaaaagaa aagaatgagc atggcaagaa cataataaca 148800 gacaaaaact tccaattctg gtcttctgtt aatcctaggt ctattaagag aatgggggat 148860 ggaggaacaa tatgattata gctgatacat acggctactg accattaagt gtccatattt 148920 tctgctggct gaattatgcc aattctctgt acagcaccat aaaggatcta catttgtttg 148980 gggattcaaa atattacaca atttacttca tcagctagaa aacaaagccc tacataagac 149040 agaagaattc tattaaaaga ggaagaaaga ttacatttcc atttttttct tgtagattag 149100 aaaaagtgga tcttttccaa tgccagagct taagctgtca atttcattcc ccaatatgac 149160 atcaaatggt taccctgtgc tgtacccaac tggattgtca tcttctgagg taagtcatgt 149220 gtgccttgga attatgtcat tactgttatc ttttccactt tatgtttaag ccttttgttc 149280 tgcatgatac ttgtaataaa gaattttacc aaagtaacat ggagaggtat ttagataatt 149340 aaaagcaaat aataatagat gtattattcc ctagagctgc tgtaacaaat tatcacaaat 149400 tgagtgactt aaaacaacac aaatttattc tttcacggtt ctggagtcca gaagtccaaa 149460 atcaaggtgt tgacagtgtt aattccctct ggaggctcca agagagactc tttctcatgc 149520 tgttttccta gcttctggtg acaactggca accctagtcg ttccttggct tgcggcagca 149580 tagctcctat ctctgcctct gtcttcacct ggccttctct gtgtttctat gtgttctcct 149640 tctctctttg tgtttctgca cactcaccat tagatttagg gtccacccta aatccagagt 149700 gatctcatct ggagatcctt aatataatta tgtctgcaaa gaccctattt ccaagtaaag 149760 tcatatttac tagttctagg gagatttagg catatctttg gggaccacta ttcaatccac 149820 tagagtagat tttaaataat tcattgttat gaaatgtttc ttacactttt ccttgatttg 149880 tggtaatcaa acaactctat aaagtgactt cttaattgta cctaagcatg cacagctgca 149940 aacaaaatag tataattgta tttactcaca tcccaaataa tagcaatatt gcaccccctt 150000 tatattttta gcttgaatga gactatatga tggttcatta tggtttagtg cctaaaacaa 150060 aaaatcacca taagtattga attaatgtgt gcatgatgtc agaatttgga aatctgtctt 150120 ttcatgcatt ttttaaagtg ttcccagaaa tcaagaaata gcaacaatgc taattggctt 150180 gtgatcactt aaatgttttc ctaagggcaa ggaaaaaata agcctttgga atttccctct 150240 aatccaaaaa agcaggtttg tgaaaatcca gaagagaaaa aaaaattgta cttttcatac 150300 tgcttaggaa actttaatct tattaacttt tgtcaaggat attgacagta ctggggaagc 150360 aaaaggttta ctaggttaag tctagaacca gctatcttat aaatatagca ttttaacata 150420 atatattaac atctataggg ctgtctgctt acgtctacct cccatgtaga ctgagtgtcc 150480 tatccttggt gtgtagggaa tcaaaagtat tactggatga atacataaat acagatgaag 150540 gtctctcgct tttcaattgt ttcatgagcc ataatattga acaagtattt ttgttgtttt 150600 tgtttccttt tttttgagac ggaatctctc tctgtcaccc aggctggagt gcagtggcgc 150660 gatcttggct tactgcaacc tcctcctccc atgtccaaat gattctcctg cctcagactc 150720 ccaagtagct gggactacag gcgcctgcca ccacacccaa ctaatttttg tatttctagt 150780 agagatgggg cctcaccatg ttggccaggc tggtctcgaa ctcctgacct caggtgatcc 150840 acccacctcg gcctcccaga gtgctagaat tacaggtgtg agccactgtg gctggccgtt 150900 gtttttgttt ttatcagtag aatttaaatg cttttctctc tctgtagtat agaatttata 150960 agcttatctt tgattaaggt aataatgaat gtattaatca cgtaatagta agttctatta 151020 gcattctttc ttttccatta caacctcact agtttccatt acaattcaaa agtagcatgg 151080 taagagtaca tattatcttg gggtggatat atatgtatgt atggctggtg cataacaacc 151140 tttcccatac agcacactta caaagatgga tctctaatat atggcaatgg ctgtcattca 151200 cagattcttt acactactgc agcaagtcat gtttttcctc tgatatctgg cattgtctga 151260 taaatgtaat attttcattt ctagaatgca aactgcagac cccatatctt tgaggatcct 151320 ttcagtatca actctggaaa gaaaatgact acatcaactg accatctcaa acgaggcaca 151380 attctggtaa attaagacaa gtgctatttt taccttttgc tttccaaatg aataaaattg 151440 atatcaatct agaaataacc atctgaagaa tttaaatata gatatttgat aaaacggcaa 151500 gaatactgat atgtatctct ggacatttaa acaggactgc aatacatgta aatttgctac 151560 catcacatgt aatctcactt cttctgacat cagccaagtc aatgtttcgc ttatcttgtg 151620 gaaaccaact tttataaaag taagtaaata catagttcta tgcacttatt gaataatatc 151680 aataaatatt catttaccac ttagaatatg caaggcactg tgctgctttt ggaaagaatg 151740 tgcgactgga agtataagag gatgtgacca agccccagct ctacttaacc agctatgtgt 151800 gtctcatctt ccttgtctgt taagaactaa gatattacca aggtcccctc tggagagata 151860 tacttttttc aatctctctt atcctttttc tttgtacttt aagagataaa tacctttcca 151920 gtaccaaagc ttgcacttat cttaatactt tggaactcag ttaatgtaca gagtataata 151980 aagtggcaac ccttgacccc agtaacaaag gaaagagcta acatatacca tagacttact 152040 gtgttttatc agactgttat tatatgtata attttataat atataggtat atatgaagcc 152100 ttttttcttt tttttttttt tgagacggag tgtctctctg tcgcccaggc tggagtgcag 152160 tggcacgatc tcagctcact gcaagctcca cctcccgggt tcacgccatt ctcctgcctc 152220 agcctcccga gtagctggga ctacaggcgc ccaccaccac gcccggctaa tttttttttg 152280 tattttagta gagactatga agacattttt aaccccttat aaagccaaat ctgtctgaca 152340 ataagctact ttaaaacttt ttattgtatt ttgtattatt tatttctcag gaagtattta 152400 gttgaacata tgactttgcc atttttgaat ttgattatag taagttgcta tttttatgtc 152460 attaactgtt aatattggca atttcatttt ttaaatttca actttaattt tagatacagg 152520 gagtatacat gcacgagttt gttacatggg tatatttgca ggatattgag gtttagggta 152580 cagattccat cgctcaggta gtgggcataa tacccaatag gtagtttgtc agctcctcca 152640 agtagtccat ggtgtctact gttcccatct ttatatccat gagtacccaa ggcttaactc 152700 tcacttatac gtgagaacat gtggtatttg gttttctgtt cctgtggaat ttgcttagga 152760 ttatggcctc catctgcatg tatgttgctg caaaggacat gattttgttc ttttttatgg 152820 ctgtgcagtg ttccatggtg tatatgtaca tattttcttt atccaggcca ctgttgatgg 152880 gcacctatgt taattccatg tctttgctgt tgtgaatagc actgcaatga agatatgacc 152940 gcacgtgtct ttttggtaaa cagtttcttt cgggtatata cacccagtaa tgggattgct 153000 gggttgaatg gtagttctgt tttaagttgt ttgagaaatc tccaaactgc tttccactgg 153060 ctgaactaat ttacatcccc accaacagtg tataagcttt tccttttctc tgctgcctca 153120 ccattttctg ttattttttg acttcttaat aatagccatt ctgactggag tgagatggta 153180 cctacctcat tttggctttt atttgcattt ctgtaatgat tagtgataat gagagttttt 153240 tcatatgttt gttggtcacc tgtatgtcat gttttaagga gtctattcat gtccttcgcc 153300 cattatttaa tgtggttatt tgttgattga ttgcttgctg agttgttcaa gttccttatt 153360 ctggatatta gacctttgtc agatgcatag tttgcaatta ttttctccca ttctgtaggt 153420 tgtctgttta ctctattgat aatgtctttt gttgtgcaga agctctttag tttaattaga 153480 tcccacttgt caatttttgt ttttgttgca attgctttta gagacttagc caaaaattat 153540 ttgccaagac caatgtcaga gagggtattt cctaggtttt cttataatat ttttatagtt 153600 aaaggtctta tatttaaatc tttaatttgt cttggttagt ttttatatat ggggaaagtt 153660 aggggtccag tttcattctt ctgcatatgg ctagccagtt atcccaacac cattttttga 153720 ctagggattc ctttccccat tgcttgtttt tgttggcttt atcaaagatc agacggctgt 153780 aggtatgtgg ctttatttct gaattctcta ttctgtttca ctggtccatg tggctcttct 153840 gtaccagtat catactgttt tgattaccgt agccttatag tagagttcga agtcaggcag 153900 tgtgatgggt ctggctttgt tctttttact taggattgct ttggctacct gagctctttt 153960 tttagatcca catgaatttt agaatagttt tttctaattc tgtgaaaaat gatgttggta 154020 ctttaagagc aacagtgtta aatctataca ttgctttggg cagtatggcc atttaatgat 154080 attaaatgaa aggttttttc ttttatttgt ctcatctctg atttctttca gcagtgtttt 154140 ttaggtctcc ttttagagat ctcttacctc cttggttagc tgtattcctg gatatttcag 154200 tgttttttgt agcttctgta aatggagttt tttttttttt tttgagacgg agtctcgctc 154260 tgtcgcccag gctggagtcc agtggcgcga ccttggctca ctgcaagctc cgcctcccgg 154320 gttcacgcca ttctcttgac tcagcctcct gagcagctgg gactacaggc acccaccacc 154380 atgcccggct aatttttttt tttttttttg tatttttagt agagatgggg tttcactgtg 154440 ttagccagga tggtctcgat ctcctgacct catgatctgc ccacctcagc ctcccaaagt 154500 gctgggatta caggcgtgag ccaccgcacc cagccctgag ttgtgttgtt tatttgactc 154560 tcaccttgaa cattattggt gtatagaaat gctactaatt tttgtacccc tattttatat 154620 tctgaaactt tactaaagtc atttatgaat tctaggagtt ttttggcaga gtcttaaggg 154680 ttttctaggt ataggatcat attaccagtg gaaaaaagat agcttgactt cttctattcc 154740 tatttggatg tctttatttc tttatcttgc cttattgctc tggctaggac ttagagtact 154800 aggttgaata ggagtggtaa gagtgggcat ccttgtctta ttccagttcc ccaggggaat 154860 ggttccagct tttgcccatt cagtatgata ttggctagga ttagttacag atgactctta 154920 ttatttggag gtatgtttct ttgatgcctg tctctaccta gagttcttgt gctgattctt 154980 tctcatcttg ggggactgat gttcttcaac tgtggtgtaa gttgagtgta gtcatttggg 155040 tttgtttctg gatgctttca gagggccaag tctctgtaca ggatctttat ttgtgggtgt 155100 atgctcacag gagtgtttat tagcaaagta atttttggtg ttgttgtttg agctgtgatc 155160 cagtagaggg caattaaggg taatgggcag tagataggct cttagtcttg ccactcttgt 155220 atttgctcat gtttgcaggg gtgctctgca gtgggtaggg agaggcctcc tccaatcact 155280 ggcactgtac ccatgtttct tttgttaggt gttctgggcc acaggctctc tcgggcagag 155340 gccatggcag gtagataggt gacacctttt ccgaaccagc cctgtggagg gagtcatgcc 155400 ctactccagt gctggcccac gctggcccac gaatccatgt ttgttaccca tctcagtgct 155460 ctgagatggg ggctcctccc ctacttgagt gccagccata gatctcagct tggtactcct 155520 gagacggaca tgccatctct gggtctccag gacaccccgc agctcagagt caggctctgg 155580 ttgctttgga ggatccaaag tcctcccagg tcacagggaa agtactcagg tggggcgcag 155640 cacccaggct gggcggcaga gactgcgctg tgcacatgct cctgtggggc agttaggcag 155700 ggactctggg agggtctggc aggcgggaga ggctgcagaa cagacatgcc ccagtcccat 155760 ggggaatgcc tgctttctcc tggcttgtgg tcacctgggg ctagagcctc tctgaaggag 155820 atggggagtc cgaggggatg ggcacctatg tctgtgctct gctcacaaaa gctcctgggc 155880 tccatgctag ctgaagccct gtctctacct gctccctggg aaaatccacc tgccagctca 155940 cacatccatt ggagatgttg ggtactctgt agcttagatc ccagatgtct gtggcaagag 156000 tgagctgtcc ctcagtcccc tccctcaccc cttctccagg agccatttag ggccaggaag 156060 tagcccaagc attcaggtac cctacgcagg gttcccagct tctccctctt cagcctcagc 156120 atctgtgttg cctctccaca cacttgcggt gttttctccc tagagatcag atctgcccaa 156180 attatattat ttacttgata atttgggatc tcttagtggg agagatggct gtgtctagtt 156240 agccatcttg tccccctaga tcatcaattt catttttaat cctaaataag tgcctagata 156300 aacttcatca ccagaatgta gttgtttcat gtcttgctac attaaaggta ggcagagttt 156360 gaggtttgtt ttttctaatg ataaatcaat acaaaatatt tttaaaattt tttttcattc 156420 cataacgagg atctaagtaa ggattttcag tggcaaatga gggaggacaa gtgcacggtt 156480 attatttgat actaccagtt ccatttggaa gttaacaaaa ctggaatttt taatctctca 156540 gaaaaatctt agcttttata aatgtcctac tcaaacatga ctagctctca ttttgattag 156600 catcatatat taagaacaaa tcctatttgc ttttcagtca tatttttcca gcttaaatct 156660 tactataagg ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca 156720 aaaaagagag gtaagtgcaa catgagtttt gaaaacatta tgcatttcac tctgaatttt 156780 gtgacataat gttttataat tgttgatagt cccttaagca gtgactggta ttgctctcgg 156840 taagtgacag acactatttg cttcaaatta tacttcatta gcttcaaatg tgattttagt 156900 cttattcatc cttgtaagac actgggaaaa tcatgatatt tacaattcac atgccgcatt 156960 tgactttatc acttataact atcacggtaa atggatgttt ttactttcac tttgataaca 157020 aatgatgcag ttgtaacttt cctccttaaa agctgacatt ataaaatgca gctgatatct 157080 gaagagcagc cgcaaaaaac aacttcttta taaaaagtgc ctttatactg tacaggaaaa 157140 catgtacatt ttttaaagtt ttctttcaaa tttcattgag aaatttgaaa caaaaaagtg 157200 atggtatttc ctaatacaaa ttcagacttg agtcctcagt aaaaatagaa aggtttgagt 157260 ttttaactct tgtccttttt ataaattaat aagccaaggt gacggagtaa gaccccatct 157320 ctaaaaaaat aaaataaaat aagtacttgt tacacatgca ggcacttcag catgatctcc 157380 ccccttctca tgggagactt taaatatccc atgtggataa cagcaccatg tgaatcataa 157440 aattcaattt ggaagctccc taactttcag atgttctttt taaattgctt atttcaaatt 157500 tttccaatat caatgacttc tgataagtat acgcttttca agaaaaagga aaatacatgc 157560 atataatgtt tacttatgtc ataaagagcg cttagcataa gcaatgcaaa atgcaaagtt 157620 gttccttaca tagaatagcc aacatttcac taaaacctaa aaaatttgag tatggtttat 157680 gttggaaaag tacatatgat tcctaaattt atgtgttaaa attttataat gagttttatt 157740 ttccctaaat attagttaaa aattcccctg gaaatattta ttctacattc atcctaaagg 157800 aaaaattata tctatattga taaaattact aaaagtgatc attttgtaat tgtgtgatct 157860 gaggaaagtc actgatctta tctagattcc ggtttccata tctgtaagtt cagggaattg 157920 ttttacatat gtttaaaatc tgccttgctg ggcttagtgg ctcatgtctg tcatcccagc 157980 ctactcggga gactgagatg gaaggatcac tttagcccag gagtttgaga tcagcctggg 158040 caaaatagtg aaaccccatc tgtgttttgt tttgttttgt tttaagaaac tgtcataatg 158100 gtctgatgct gtatatgtct acattcttgc cagctctgtc acctacctgg agtgatttga 158160 gaggttttga ttagtatcat gcatatacaa atctctcccc tgttagtttc tttttctacc 158220 ctaatcttcc ctctaggtaa agaaattgag gtgttactgt taaaggcaaa tacagggctt 158280 gaactattac tagccattga tatctaccct aaattaattt ttttcaaatc ccccagggat 158340 gagacacaga gcagataggt ttcattgagg tttgagtgcc accctgagag agcttgagta 158400 gctggaacac taaaagcggt ccattttaca gctttgcttc agttaaaacc tgatttatac 158460 atgtggaccc agtgataagt caagtagaag aaacattgtg gtataatgaa gagcacactg 158520 ggagtgaata catatgcaaa cattcactta cccatacact tgacatgtat gcattatact 158580 ttcaatttat aaacaaaaaa ttatgcacac tagaaataaa ataaggagac tttctcaggt 158640 tcttatgaca acaaactgcg acattccaat ctaaactaat gctattgtga taatacagta 158700 gtgtactaat taatctttaa cacacataat actttggttc tccctgagtt aaacagaaat 158760 tcactcctcc ccttgagcat tccaatccat tgacatttaa ccctttatgt ataaatttca 158820 gaaggataat attataaata ccttttggta ataataaatt tgacatagtt agagatttag 158880 actagatgaa gagcattttc taatgtaaat ctaatgtttt ctcattatat agtaacgaga 158940 ttaatgcact ggtagagaat tgtagcctgc aagaactcaa tgttccagga gttctaatag 159000 gtgtttatta tgttaacaat cttgtttaat aattttcagc ttgctattca aatatccaaa 159060 gatgggctac cgggcagagt gccattatgg gtcatcctgc tgagtgcttt tgccggattg 159120 ttgctgttaa tgctgctcat tttagcactg tggaaggtaa acaccaaaat tcctttgact 159180 ctctacttca atcatcaaca gcaaactgga gaaataagct ctgatatatt cagactatgt 159240 aatatagtat tattacagca atgaaacaaa cgttgaaatg atgactaagg gaaagaaaaa 159300 agaaaaatgc gtatttcaaa cactgcacac aacttgaccc aatttttgta aaggaaaaaa 159360 aacttatttt aagttagaaa tagtcaaaaa ttcacaaaag tatctttcta gagtttagta 159420 tgatagggga ctttcacatg tgtaacaatt aaaattttat aataagtatg tatttctttt 159480 ataaacagag aacaatgaaa actgtctttt atagagaaag aaaaaatgaa ttcctatgtc 159540 aatttaagga tatataagca gtagattcaa ggttaaaata agccttgttt taatcacatc 159600 tccatgtgtc ttaaatatca aataattctt taatgtttaa atatatatgg cacattttat 159660 gtaataaatt gtgtgcctga gtggaggata agggatcagc tgatgtaggg gagatcttaa 159720 agtttcacag actcctattt caaattctgt ggtaaatgtg agtaaccacc tattttgtgt 159780 caagtaactc tggatattta tgtaatgttt tgcttaggct gaaatagaca tgatttttaa 159840 aactcttagc agctgtataa ttttcacatt aagtagaatt gagatgacag cttttgggat 159900 aagttgaata gagaataaca tcccatacag agttgaatgt tttttcaatt aaatatcaaa 159960 taagcattta ttctagcata atatccccct agattttacc tattgttttg ttaaatagtt 160020 aaattatgtt aaaaatatag gttgtggcta catattaatt gttctattac ctgagcaaca 160080 taattattta atcaaatagt ttaaatagca agtttctctc ccactgaaat accaactgtt 160140 cctatccttt cttactctcc tatgactcac ttcctctttt gaggggctta gtctcagagg 160200 agatggtgaa caaagccaga tgtaggtcag tggcatttaa ttcagtaaat agaatccatg 160260 gcttttctct agcaaagttc cccaaacaaa attctccact atagccaatg tccagctctt 160320 ccttctactt tataagggat cagtgttctc tctgtaatac ctagctttgc cacactgtgg 160380 tacccaaggc ctggcttatt ggtgtcaagg ttgtacttga aatataggaa gtggtttctt 160440 catttctatg cacctctaat agagagtgtt actgttgatt tttttcagca tagtcttctg 160500 ttctcagcac tgcacttacc tctatggttt tagaacaccg ctggcaggag aagaggaaaa 160560 ccagagctga tatttggata ggttctttca ggccttgtac ctctgtttca gacaaacaaa 160620 taggaaattt cagtcaccta tttttcagtc agtagtctga aaaagcataa atgtaaaact 160680 aagctcattg tttcatccag ataatgatgt gttgatacat tctgacagct tcttaggtta 160740 ttattaatat tattattatt gcaggcccaa aagaagatca tttgacaaac tttgggctgt 160800 cttacccggt agaaatagtt cagccacttc attgggaggc ccagcaatca gaactgtgat 160860 tctaaggtag aagggaagaa actagctctt atcgaatgct tactatgtgc agggagctat 160920 tttaaacatt tctgctttaa gcattcccac ttaatactca tatcaacctt atgaggtcgt 160980 atgaacctcc tcttttaagt gaagaacata aaatttaagt atatttccca aagacacata 161040 gtgagattca gagtaaggat ctgaattctg tgccaaaacc actgactatt atcactctgt 161100 gttctctctt gcttccattc actctggtgt ccttgcaaca atcttttcga ccaagtattt 161160 taactacatt ttacacctga ggacattaaa gcaaagggag gtaaagtgac tctcccatga 161220 ttactagcta gtaaatgact ggattcaagg aatgatctac agagctcttt ctttttccaa 161280 tatatcctac tgctgcaggc tatagggtag ggctctttac tctggagctc caggagttgg 161340 gttttgttca agagagtcat gaactctctt aaacacataa tactgtcttt ggttttggaa 161400 tgagggtccc tggttggatt cagactttcg gtagttccat tatatcaaga aggctaatcc 161460 cacttccccc tactttaaag ttctgttgga agctgcctga agcatgagtt cagttgcagt 161520 aggttcagaa gagctactct tatcccagac atctttttta ttctaactag atctggatca 161580 gacacctcag gactatccct tcttccttcc tttcctgaat cccaccagtt tggagttcat 161640 tggaactccc aagtctgagt ctctgtgtaa gagacaggcc aaaagtttct cttagagcag 161700 agattcactt tcaaaagaca cagtctttat atctttgtct tcatcataca catggcaaaa 161760 attaaagctt gacaaagtgt tagtagctgc ttaatacact tcatgattga tgggaggaat 161820 cttgtagggg acgtaggttt aaataggtgg agaaacttgt cctgaactgt ggtaccacat 161880 gccgggggag atgccagcac accaggagcc atgagagact cagaacattc ctctctccta 161940 acttgatgtc ataatgatgc ctgaagttcc tcaactgatg atttatttat taatcctaaa 162000 gctttattct tcatccaata tacatgttct gggtgggtgt ggatggggac tggtgtctca 162060 ccacttttta gtcttttata cattagtatg aatttattca ttcagcaatt attccatgtt 162120 atattcatta agcacttact tttctgacag ttatcacctc attagagcct ttgccatagg 162180 gttttgaaca agggatcatg aagcaaacac aggaaggaaa aaatgaaagc cagtgctgca 162240 aagaaagtgt tggggctgaa aacaaactct attggtttca aatttgggct aggattggcc 162300 cagtccatct tgaagctata aactattttc tcctaatctc cactctttgc cactcaactt 162360 ctcttaaaaa cccatgttaa ttggttgggt ggagtgctta gataacagaa gttattttaa 162420 aatagaacat ttaatgtgta gaagccaagg agcattgtaa agaagcaaaa agagctgtga 162480 gagatcagaa gcaaagcaga gtgggaagga gaaaaagtct tagaatccac cacctgcttt 162540 tgtgaaagcc ttgtctgttt atttttgact caggacatgc aggcacaagt taagaagcct 162600 aatggtttgt gaatctggaa cttttatact tggctcatat gaaaaagcct gagacgtgta 162660 ggagagctgg catttgggga agaaaaactt attgttttca tgtgtatttg ttccgttacc 162720 gccttttctt catctaccac caactagatg atggcataat agaagacatg agccctgaat 162780 aaaaattttc caacctaaaa gtgcatattt ttgagggttt atcccctcta agccctcagt 162840 tgtttaataa ttattttata aacacatagt tccctggcat aatttgccat aatttcgtga 162900 ttaaaatgat gtagaggtgc cacactttta aagaattaac tcattgcctt tgctcgatct 162960 attatagccc cctctcaaat ttaaaaaata tatacaaatt tgaaaaatca cttacctatg 163020 acccttaatt ttcttttttt aaaaataagc attttaggtt agataattgc aaagatccct 163080 tctatccccc atacttagtt ttgttattct ataggatggg aaacaattgc agcacttata 163140 actttttatg atgccccaaa ttgcaaagca taatgaaata tggctcacca tccaccacga 163200 tgtgaaattt ttcttatggt caacaacttc attttttatt tccaaatgat atagtgtgtt 163260 ttcaagaggc tttttatatc aaatctatat aagcagacgt cctgatgcat ttaaagttaa 163320 tacagacaac tcagaaatct ccctaacgcc ctagccataa tatacctgtc agattcccta 163380 ccatctctaa tgacctcaac ttatggtcat cgatcatttg atggaaattt ctctgccaca 163440 tccctgaaaa aaaagatgat ggcaaagaag agacaatgct agctaattgc agtttgtctc 163500 ccaaaatatt ttcccagaag cttttaatta gttcaatgtg tatactatat tttactaggg 163560 gtcatggtgt atttaaccaa tgaaaatatt aaaaatgaaa ccgcggcccg gcgcgatggc 163620 tcacgcctgt aatcccagca ctttgggagg ccgaggcagg cagatcatga ggtcaagaga 163680 tagagaccat cctggccaac atggtgaaac cccgtctcta ctgaaaatac aaaaattagc 163740 tgggcatggt ggtgcatgcc tgtagtccca gctacccagg aggctgaggc aggagaatca 163800 cttgaacccg ggtggcggag gttgcagtga gcggagatca cgccactgca ctccagcctg 163860 gtgacagagt gagactgtct caaaaaaaaa aaagaaaaga aaaaaaaaga aacagcaatt 163920 taataaatgt cattttttga cattgaatat taataggtca atgagaaaat atttcttaat 163980 tatattagtt gtgtgcccag cattgccaat atactattaa atttaattct atccaaagga 164040 ttaatatttg ctacctaaat taaaatagtt aattgtgtta tgttttgtgt tttctcaaca 164100 gattggattc ttcaaaagac cactgaaaaa gaaaatggag aaatgaaata ttttatgaaa 164160 gaaaataata acaattattc aataatctat cctcaggttt gcctcaaata tgtgacaaga 164220 aatgtataat tcatgacata gtcatgtaac tatgtaatcc atcagggatt cattacttgg 164280 aaaatgacag gtcatgcatt atccaaaaac aataccaaaa agacatattt tataaaatga 164340 caaaaaatat tttacataat tactcatttt tgttgagtaa gcaaaattac aaagtgtttt 164400 taaaaaaacc tgtacaaata tgtttatgta ttaaatcacc atccaaaata tttaaggaat 164460 atataaaaag atttttatga tcatagaaac atctattttc aaaacaatat aaattaagct 164520 tttccccttg attcctgttg gatatccatg ttcagcatga cagtcagcac tcgtaaatgc 164580 caagaaaaga attacctgaa aaagatcatt tctccctatt caaatgagaa tattttccct 164640 tggtagaatc catatacaat atggattgaa aattaagtca ccaagaatac atttagcatc 164700 tttgtgttgg gttctatacc taaaaatttt ccctccctgc ccaaggtgat tggaaagtac 164760 tgcaattgag ctaaaatttt atctaggatg gaaaatcagg atagactcgt ttaaaaacaa 164820 gtatattaaa tgggttaaat taagctttta cagaacatgc ttaattttga tattgagctc 164880 taaatgcaaa actcttttat actgaaaaaa cacttaaagt agttttgtgt ggcatcacag 164940 tgatttgtca tgaaaagcca tatatggggg acatgctaaa atggcttctg aatgaaatac 165000 gacagcagag aaagatgcca ctgaaatgct gaaattatct ttgctgagca gcttttgaat 165060 gctaagggtt ccagtatgtg acccaaagaa agagttgtct caactccttg gtacagggtt 165120 cattcaaacc cccaagctgt gagagtgtgt ttatttttaa ttttttaaaa ggtatttaat 165180 ttccaaccac acttcttatt tttttgaaaa gacaattttc catttcagta ttacatttta 165240 ccaagaagtc actgcttttt aggtgtgttg catcaatatt taaataaaat cccagaaatg 165300 tattttaaag aatttcaggt ttgaaaactc aaaccaacag gaagatatca 165350 <210> 95 <211> 4811 <212> DNA <213> Homo sapiens <400> 95 ggtcctgccc tgcgaaccag cgcggccccc tggcgctgag gctgctccgg ccatggcccc 60 tcggccccgc gcccgcccag gggtcgctgt cgcctgctgc tggctcctca ctgttgttct 120 acgctgctgc gtatcattca atgttgatgt gaaaaattca atgactttca gcggcccggt 180 ggaagacatg tttggatata ctgttcaaca atatgaaaat gaagaaggaa aatgggtgct 240 tattggttct ccgttagttg gccaacccaa aaacagaact ggagatgtct ataagtgtcc 300 agttgggaga ggtgaatcat taccttgtgt aaagttggat ctaccagtta atacatcaat 360 tcccaatgtc acagaagtaa aggagaacat gacatttgga tcaactttag tcaccaaccc 420 aaatggagga tttctggctt gtgggccctt atatgcctat agatgtggac atttgcatta 480 cacaactgga atctgttctg acgtcagccc cacatttcaa gtcgtgaatt ccattgcccc 540 tgtacaagaa tgcagcactc aactggacat agtcatagtg ctggatggtt ccaacagtat 600 ttacccatgg gacagtgtta cagctttttt aaatgacctt cttgaaagaa tggatattgg 660 tcctaaacag acacaggttg gaattgtaca gtatggagaa aacgtgaccc atgagttcaa 720 cctcaataag tattcttcca ccgaagaggt acttgttgca gcaaagaaaa tagtccagag 780 aggtggccgc cagactatga cagctcttgg aatagacaca gcaagaaagg aggcattcac 840 ggaagcccgg ggtgcccgaa gaggagttaa aaaagtcatg gttattgtga cagatggaga 900 gtctcatgac aatcatcgac tgaagaaggt catccaagac tgtgaagatg aaaacattca 960 acggttttcc atagctattc ttggcagcta taaccgagga aatttaagca ctgaaaaatt 1020 tgtggaggaa ataaaatcaa ttgcaagtga acccactgaa aagcatttct tcaatgtctc 1080 tgatgaattg gctctagtca ccattgttaa aactctggga gaaagaatat ttgccctgga 1140 agccacagct gaccagtcag cagcttcatt tgaaatggaa atgtctcaga ctggcttcag 1200 tgctcattat tcacaggact gggtcatgct tggagcagta ggagcctatg attggaatgg 1260 aacagttgtc atgcagaagg ctagtcaaat cataatccct cgaaacacaa cctttaatgt 1320 tgagtctacc aaaaagaatg aaccgcttgc ttcttattta ggttacactg taaactctgc 1380 tactgcttct tctggagatg tgctctatat tgctggacag cctcggtaca atcatacagg 1440 ccaggtcatt atctacagga tggaagatgg aaacatcaaa attctccaga cgctcagtgg 1500 agaacagatt ggttcctact ttggcagtat tttaacaaca actgacattg acaaggattc 1560 taatactgac attcttctag tcggagcccc tatgtacatg ggaacagaga aggaggagca 1620 aggaaaagtg tatgtgtatg ctctcaatca gacaaggttt gaatatcaaa tgagcctgga 1680 acctattaag cagacgtgct gttcatctcg gcagcacaat tcatgcacaa cagaaaacaa 1740 aaatgagcca tgcggggctc gttttggaac tgcaattgct gctgtaaaag acctcaatct 1800 tgatggattt aatgacatcg tgataggagc tccgctggaa gatgatcacg ggggagctgt 1860 gtacatttat catggaagtg gcaagactat aaggaaagag tatgcacaac gtattccatc 1920 aggtggggat ggtaagacac tgaaattttt tggccagtct atccacggag aaatggattt 1980 aaatggtgac ggtctgacag atgtgactat tgggggcctt ggtggtgctg ccctcttctg 2040 gtcccgagat gtggccgtag ttaaagtgac catgaatttt gagccaaata aagtgaatat 2100 tcaaaagaaa aactgccata tggagggaaa ggaaacagta tgcataaatg ctacagtgtg 2160 ttttgatgtg aaattaaagt ctaaagaaga cacgatttat gaagctgatt tgcagtaccg 2220 tgtcacccta gattcactaa gacaaatatc acgaagtttt ttctctggaa ctcaagagag 2280 aaaggttcaa aggaacatca cagttcgaaa atcagaatgc actaagcact ccttctacat 2340 gttggacaag catgactttc aggactctgt gagaataacg ttggacttta atcttaccga 2400 tccagaaaat gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc 2460 ctttgccaaa gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc 2520 caccactgaa aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct 2580 cacagtcaaa aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc 2640 aaatctagtt ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa 2700 tatcacatgt aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat 2760 attgtttcag tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac 2820 aagtgacagc gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc 2880 ggtaaaatat gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat 2940 tgctgccaat gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat 3000 taatatcttc tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc 3060 aatttcattc cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc 3120 atcttctgag aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc 3180 tggaaagaaa atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa 3240 tacatgtaaa tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa 3300 tgtttcgctt atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct 3360 tactataagg ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca 3420 aaaaagagag cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg 3480 ggtcatcctg ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact 3540 gtggaagatt ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt 3600 atgaaagaaa ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg 3660 acaagaaatg tataattcat gacatagtca tgtaactatg taatccatca gggattcatt 3720 acttggaaaa tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata 3780 aaatgacaaa aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag 3840 tgtttttaaa aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta 3900 aggaatatat aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat 3960 taagcttttc cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt 4020 aaatgccaag aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt 4080 ttcccttggt agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt 4140 agcatctttg tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga 4200 aagtactgca attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa 4260 aaacaagtat attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt 4320 gagctctaaa tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca 4380 tcacagtgat ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg 4440 aaatacgaca gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt 4500 ttgaatgcta agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac 4560 agggttcatt caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta 4620 tttaatttcc aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac 4680 attttaccaa gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca 4740 gaaatgtatt ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatcaaaaa 4800 aaaaaaaaaa a 4811

Claims

골다공증에 대한 감수성을 예측하기 위한 서열번호: 94의 염기서열로 구성된ITGA1 유전자 다형성 마커로서,

상기 유전자 다형성 마커가 ITGA1 유전자의 단일염기다형성 중 +73187C>T (엑손 3) 또는 +76969T>G (인트론 5)이고,

상기 유전자 다형성 마커는 대퇴골 경부 및 대퇴골 간체의 BMD와 연관되어 있음을 특징으로 하는 ITGA1 유전자 다형성 마커.
골다공증에 대한 감수성을 예측하기 위한 서열번호: 94의 염기서열로 구성된ITGA1 유전자 다형성 마커로서,

상기 유전자 다형성 마커가 ITGA1 유전자의 번역개시점으로부터 +73187번째 염기가 C이고 +76969번째 염기가 T인 일배체형 BL1_ht1, 또는 ITGA1 유전자의 번역개시점으로부터 +73187번째 염기가 T이고 +76969번째 염기가 G인 일배체형 BL1_ht2이고,

상기 유전자 다형성 마커는 대퇴골 경부 및 대퇴골 간체의 BMD와 연관되어 있음을 특징으로 하는 ITGA1 유전자 다형성 마커.
골다공증에 대한 감수성을 예측하기 위한 서열번호: 94의 염기서열로 구성된ITGA1 유전자 다형성 마커로서,

상기 유전자 다형성 마커가 ITGA1 유전자의 단일염기다형성 중 +159174A>C (인트론 28)이고,

상기 유전자 다형성 마커는 골절 위험도와 연관되어 있음을 특징으로 하는 ITGA1 유전자 다형성 마커.
골다공증에 대한 감수성을 예측하기 위한 서열번호: 94의 염기서열로 구성된ITGA1 유전자 다형성 마커로서,

상기 유전자 다형성 마커가 ITGA1 유전자의 번역개시점으로부터 +159174번째 염기가 C이고 +164104번째 염기가 C이고 +165697번째 염기가 T인 BL3_ht1이고,

상기 유전자 다형성 마커는 골절 위험도와 연관되어 있음을 특징으로 하는 ITGA1 유전자 다형성 마커.
골다공증에 대한 감수성을 예측하기 위한 서열번호: 94의 염기서열로 구성된ITGA1 유전자 다형성 마커로서,

상기 유전자 다형성 마커가 ITGA1 유전자의 번역개시점으로부터 +109100번째 염기가 T이고 +110140번째 염기가 G이고, +130991번째 염기가 C인 ITGA1 유전자의 일배체형 블록 (haplotype LD) BL2_ht3이고,

상기 유전자 다형성 마커는 와드 삼각부의 BMD와 연관되어 있음을 특징으로 하는 ITGA1 유전자 다형성 마커.
삭제
(1) 개체로부터 DNA 샘플을 수득하는 단계;

(2) 단계 (1)에서 수득한 DNA에서 제1항 내지 제5항 중 어느 한 항의 유전자 다형성 마커를 검출하는 단계; 및

(3) 단계 (2)에서 검출된 다형성 마커를 확인하는 단계를 포함하는, 골다공증에 대한 감수성에 관한 정보를 제공하는 방법.
스크리닝용 프라이머 세트가 서열번호: 1 내지 서열번호: 62로 이루어진 군에서 선택되고, 지노타이핑용 프라이머 및 프로브 세트가 서열번호: 63 내지 서열번호: 93로 이루어진 군에서 선택되는 것을 특징으로 하는, ITGA1 유전자 다형성 검출용 키트.
삭제