KR101561760B1 - 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법 - Google Patents

옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법 Download PDF

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Publication number
KR101561760B1
KR101561760B1 KR1020137031487A KR20137031487A KR101561760B1 KR 101561760 B1 KR101561760 B1 KR 101561760B1 KR 1020137031487 A KR1020137031487 A KR 1020137031487A KR 20137031487 A KR20137031487 A KR 20137031487A KR 101561760 B1 KR101561760 B1 KR 101561760B1
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Prior art keywords
thiol
michael
oxycodone
composition
michael acceptor
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KR20140002807A (ko
Inventor
줄스 에이. 샤퍼
블라디슬래브 브이. 텔야트니코브
하오 왕
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콘드롤드 케미컬즈, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cleaning Or Drying Semiconductors (AREA)
  • Processing Of Solid Wastes (AREA)
KR1020137031487A 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법 Expired - Fee Related KR101561760B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73908705P 2005-11-22 2005-11-22
US60/739,087 2005-11-22
PCT/US2006/045316 WO2007062184A2 (en) 2005-11-22 2006-11-22 Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020087015013A Division KR101417135B1 (ko) 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체수준을 감소시키는 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020157007999A Division KR20150041176A (ko) 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법

Publications (2)

Publication Number Publication Date
KR20140002807A KR20140002807A (ko) 2014-01-08
KR101561760B1 true KR101561760B1 (ko) 2015-10-20

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Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020137031487A Expired - Fee Related KR101561760B1 (ko) 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법
KR1020157007999A Ceased KR20150041176A (ko) 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법
KR1020087015013A Expired - Fee Related KR101417135B1 (ko) 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체수준을 감소시키는 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020157007999A Ceased KR20150041176A (ko) 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법
KR1020087015013A Expired - Fee Related KR101417135B1 (ko) 2005-11-22 2006-11-22 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체수준을 감소시키는 방법

Country Status (8)

Country Link
US (4) US7875623B2 (https=)
EP (2) EP2402346A1 (https=)
JP (2) JP5415075B2 (https=)
KR (3) KR101561760B1 (https=)
CN (2) CN101346384B (https=)
CA (1) CA2630703C (https=)
MX (2) MX2008006710A (https=)
WO (1) WO2007062184A2 (https=)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
EP3175780A1 (en) 2003-12-18 2017-06-07 Metronom Health, Inc. Implantable biosensor and methods of use thereof
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
CN101346384B (zh) 2005-11-22 2012-07-04 控制化学品公司 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
MX2008010921A (es) * 2006-03-02 2008-09-03 Mallinckrodt Inc Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados.
US7875719B2 (en) * 2006-12-04 2011-01-25 Cox D Phillip Process for reducing impurities in oxycodone base
JP2010511726A (ja) * 2006-12-04 2010-04-15 ノランコ・インコーポレーテツド １４−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法
FR2923484B1 (fr) 2007-11-09 2012-11-09 Sanofi Aventis Procede de preparation de composes morphiniques
WO2012003468A1 (en) 2010-07-02 2012-01-05 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
RS58427B1 (sr) 2012-08-03 2019-04-30 Johnson Matthey Plc Postupak za pripremu oksikodona
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
CA2954600A1 (en) 2014-07-09 2016-01-14 Rhodes Technologies Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions
US10695000B2 (en) 2015-09-02 2020-06-30 Metronom Health, Inc. Systems and methods for continuous health monitoring using an opto-enzymatic analyte sensor
CN109725065A (zh) * 2017-10-31 2019-05-07 中国石油化工股份有限公司 一种轻质油中硫醇类化合物的分析方法
CN113237988B (zh) * 2021-04-30 2021-12-31 北京济圣康泰国际医药科技有限公司 一种羟考酮液体制剂中降解杂质羟醛二聚体含量的检测方法

Citations (1)

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WO2005097801A1 (en) * 2004-03-30 2005-10-20 Euro-Celtique S.A. Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone

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US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
JP2001505558A (ja) 1996-11-15 2001-04-24 シンソーブ バイオテック，インコーポレイテッド 炭化水素ライブラリーのコンビナトリアル合成
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
EP1456214A2 (en) * 2001-12-14 2004-09-15 Charterhouse Therapeutics Limited Improvements in pharmaceutical compositions
CN101346384B (zh) * 2005-11-22 2012-07-04 控制化学品公司 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
MX2008010921A (es) * 2006-03-02 2008-09-03 Mallinckrodt Inc Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados.
EP2322926A1 (en) 2009-11-11 2011-05-18 Zedira GmbH Stabilized open form transglutaminase as a diagnostic indicator for autoimmune diseases

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WO2005097801A1 (en) * 2004-03-30 2005-10-20 Euro-Celtique S.A. Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone

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Also Published As

Publication number Publication date
CN101346384B (zh) 2012-07-04
MX345055B (es) 2017-01-13
JP2013079279A (ja) 2013-05-02
EP2402346A1 (en) 2012-01-04
US10201174B2 (en) 2019-02-12
CN102816167A (zh) 2012-12-12
CN102816167B (zh) 2016-01-06
JP5415075B2 (ja) 2014-02-12
CA2630703A1 (en) 2007-05-31
KR20150041176A (ko) 2015-04-15
US20070149559A1 (en) 2007-06-28
CA2630703C (en) 2014-05-20
US20170027199A1 (en) 2017-02-02
JP2009516750A (ja) 2009-04-23
WO2007062184A2 (en) 2007-05-31
US9034893B2 (en) 2015-05-19
US20150148537A1 (en) 2015-05-28
CN101346384A (zh) 2009-01-14
US7875623B2 (en) 2011-01-25
US20110136849A1 (en) 2011-06-09
US9403838B2 (en) 2016-08-02
KR20140002807A (ko) 2014-01-08
KR20080096750A (ko) 2008-11-03
AU2006318445A1 (en) 2007-05-31
KR101417135B1 (ko) 2014-07-08
MX2008006710A (es) 2008-12-16
WO2007062184A3 (en) 2007-07-26
EP1971607A2 (en) 2008-09-24
HK1179622A1 (zh) 2013-10-04

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