CN101346384B - 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法 - Google Patents

用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法 Download PDF

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Publication number
CN101346384B
CN101346384B CN2006800494626A CN200680049462A CN101346384B CN 101346384 B CN101346384 B CN 101346384B CN 2006800494626 A CN2006800494626 A CN 2006800494626A CN 200680049462 A CN200680049462 A CN 200680049462A CN 101346384 B CN101346384 B CN 101346384B
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China
Prior art keywords
oxycodone
product
component
michael acceptor
hydroxycodeinone
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Expired - Fee Related
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CN2006800494626A
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English (en)
Chinese (zh)
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CN101346384A (zh
Inventor
朱尔斯·A·谢弗
弗拉迪斯拉夫·V·捷利亚特尼科夫
汪浩
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Controlled Chemicals Inc
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Controlled Chemicals Inc
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Priority to CN201210142283.4A priority Critical patent/CN102816167B/zh
Publication of CN101346384A publication Critical patent/CN101346384A/zh
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Publication of CN101346384B publication Critical patent/CN101346384B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cleaning Or Drying Semiconductors (AREA)
  • Processing Of Solid Wastes (AREA)
CN2006800494626A 2005-11-22 2006-11-22 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法 Expired - Fee Related CN101346384B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201210142283.4A CN102816167B (zh) 2005-11-22 2006-11-22 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73908705P 2005-11-22 2005-11-22
US60/739,087 2005-11-22
PCT/US2006/045316 WO2007062184A2 (en) 2005-11-22 2006-11-22 Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210142283.4A Division CN102816167B (zh) 2005-11-22 2006-11-22 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法

Publications (2)

Publication Number Publication Date
CN101346384A CN101346384A (zh) 2009-01-14
CN101346384B true CN101346384B (zh) 2012-07-04

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CN2006800494626A Expired - Fee Related CN101346384B (zh) 2005-11-22 2006-11-22 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
CN201210142283.4A Expired - Fee Related CN102816167B (zh) 2005-11-22 2006-11-22 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法

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Country Status (8)

Country Link
US (4) US7875623B2 (https=)
EP (2) EP2402346A1 (https=)
JP (2) JP5415075B2 (https=)
KR (3) KR20150041176A (https=)
CN (2) CN101346384B (https=)
CA (1) CA2630703C (https=)
MX (2) MX2008006710A (https=)
WO (1) WO2007062184A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2659831B1 (en) 2003-12-18 2016-11-30 Metronom Health, Inc. Stabilized oxygen transport matrix
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
CA2630703C (en) * 2005-11-22 2014-05-20 Controlled Chemicals, Inc. Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions
CN101395159A (zh) * 2006-03-02 2009-03-25 马林克罗特公司 制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
WO2008070656A2 (en) 2006-12-04 2008-06-12 Noramco, Inc Process for reducing impurities in oxycodone base
ES2393221T3 (es) 2006-12-04 2012-12-19 Noramco, Inc. Procedimiento de preparación de oxicodona con niveles reducidos de 14-hidroxicodeinona
FR2923484B1 (fr) * 2007-11-09 2012-11-09 Sanofi Aventis Procede de preparation de composes morphiniques
PL2588481T3 (pl) * 2010-07-02 2018-05-30 Johnson Matthey Public Limited Company Sposób syntezy i oczyszczania oksykodonu
PL2880037T3 (pl) 2012-08-03 2019-07-31 Johnson Matthey Public Limited Company Sposób wytwarzania oksykodonu
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
MA40332A (fr) 2014-07-09 2021-04-28 Rhodes Tech Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane
CN108135929B (zh) 2015-09-02 2021-10-12 梅特罗诺姆中国Ip控股公司 使用光-酶分析物传感器进行连续健康监测的系统和方法
CN109725065A (zh) * 2017-10-31 2019-05-07 中国石油化工股份有限公司 一种轻质油中硫醇类化合物的分析方法
CN113237988B (zh) * 2021-04-30 2021-12-31 北京济圣康泰国际医药科技有限公司 一种羟考酮液体制剂中降解杂质羟醛二聚体含量的检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
AU736031B2 (en) 1996-11-15 2001-07-26 Synsorb Biotech Inc. Combinatorial synthesis of carbohydrate libraries
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
AU2002352402A1 (en) * 2001-12-14 2003-06-30 Charterhouse Therapeutics Limited Improvements in pharmaceutical compositions
TW201509943A (zh) * 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
CA2630703C (en) * 2005-11-22 2014-05-20 Controlled Chemicals, Inc. Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions
CN101395159A (zh) * 2006-03-02 2009-03-25 马林克罗特公司 制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
EP2322926A1 (en) 2009-11-11 2011-05-18 Zedira GmbH Stabilized open form transglutaminase as a diagnostic indicator for autoimmune diseases

Also Published As

Publication number Publication date
US9403838B2 (en) 2016-08-02
MX2008006710A (es) 2008-12-16
US7875623B2 (en) 2011-01-25
KR20140002807A (ko) 2014-01-08
HK1179622A1 (zh) 2013-10-04
MX345055B (es) 2017-01-13
WO2007062184A2 (en) 2007-05-31
AU2006318445A1 (en) 2007-05-31
CA2630703A1 (en) 2007-05-31
US10201174B2 (en) 2019-02-12
KR101417135B1 (ko) 2014-07-08
EP2402346A1 (en) 2012-01-04
US20110136849A1 (en) 2011-06-09
CA2630703C (en) 2014-05-20
KR20150041176A (ko) 2015-04-15
KR101561760B1 (ko) 2015-10-20
JP5415075B2 (ja) 2014-02-12
CN102816167A (zh) 2012-12-12
EP1971607A2 (en) 2008-09-24
US20170027199A1 (en) 2017-02-02
US9034893B2 (en) 2015-05-19
WO2007062184A3 (en) 2007-07-26
US20070149559A1 (en) 2007-06-28
US20150148537A1 (en) 2015-05-28
JP2009516750A (ja) 2009-04-23
CN101346384A (zh) 2009-01-14
JP2013079279A (ja) 2013-05-02
KR20080096750A (ko) 2008-11-03
CN102816167B (zh) 2016-01-06

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Granted publication date: 20120704

Termination date: 20181122