JP5415075B2 - オキシコドン及び他の組成物中の混入しているマイケル受容体レベルを低減させる方法 - Google Patents

オキシコドン及び他の組成物中の混入しているマイケル受容体レベルを低減させる方法 Download PDF

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Publication number
JP5415075B2
JP5415075B2 JP2008542458A JP2008542458A JP5415075B2 JP 5415075 B2 JP5415075 B2 JP 5415075B2 JP 2008542458 A JP2008542458 A JP 2008542458A JP 2008542458 A JP2008542458 A JP 2008542458A JP 5415075 B2 JP5415075 B2 JP 5415075B2
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thiol
ppm
oxycodone
michael
less
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JP2009516750A (ja
JP2009516750A5 (https=
Inventor
シェーファー，ジュールズ，エー．
テリャトニコフ，ウラディスラフ，ヴィ．
ワン，ハオ
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コントロールド・ケミカルズ・インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cleaning Or Drying Semiconductors (AREA)
  • Processing Of Solid Wastes (AREA)
JP2008542458A 2005-11-22 2006-11-22 オキシコドン及び他の組成物中の混入しているマイケル受容体レベルを低減させる方法 Expired - Fee Related JP5415075B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73908705P 2005-11-22 2005-11-22
US60/739,087 2005-11-22
PCT/US2006/045316 WO2007062184A2 (en) 2005-11-22 2006-11-22 Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013001763A Division JP2013079279A (ja) 2005-11-22 2013-01-09 オキシコドン及び他の組成物中の混入しているマイケル受容体レベルを低減させる方法

Publications (3)

Publication Number Publication Date
JP2009516750A JP2009516750A (ja) 2009-04-23
JP2009516750A5 JP2009516750A5 (https=) 2010-01-21
JP5415075B2 true JP5415075B2 (ja) 2014-02-12

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ID=38042645

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JP2008542458A Expired - Fee Related JP5415075B2 (ja) 2005-11-22 2006-11-22 オキシコドン及び他の組成物中の混入しているマイケル受容体レベルを低減させる方法
JP2013001763A Pending JP2013079279A (ja) 2005-11-22 2013-01-09 オキシコドン及び他の組成物中の混入しているマイケル受容体レベルを低減させる方法

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JP2013001763A Pending JP2013079279A (ja) 2005-11-22 2013-01-09 オキシコドン及び他の組成物中の混入しているマイケル受容体レベルを低減させる方法

Country Status (8)

Country Link
US (4) US7875623B2 (https=)
EP (2) EP2402346A1 (https=)
JP (2) JP5415075B2 (https=)
KR (3) KR101561760B1 (https=)
CN (2) CN101346384B (https=)
CA (1) CA2630703C (https=)
MX (2) MX2008006710A (https=)
WO (1) WO2007062184A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3175780A1 (en) 2003-12-18 2017-06-07 Metronom Health, Inc. Implantable biosensor and methods of use thereof
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
CN101346384B (zh) 2005-11-22 2012-07-04 控制化学品公司 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
MX2008010921A (es) * 2006-03-02 2008-09-03 Mallinckrodt Inc Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados.
US7875719B2 (en) * 2006-12-04 2011-01-25 Cox D Phillip Process for reducing impurities in oxycodone base
JP2010511726A (ja) * 2006-12-04 2010-04-15 ノランコ・インコーポレーテツド １４−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法
FR2923484B1 (fr) 2007-11-09 2012-11-09 Sanofi Aventis Procede de preparation de composes morphiniques
WO2012003468A1 (en) 2010-07-02 2012-01-05 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
RS58427B1 (sr) 2012-08-03 2019-04-30 Johnson Matthey Plc Postupak za pripremu oksikodona
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
CA2954600A1 (en) 2014-07-09 2016-01-14 Rhodes Technologies Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions
US10695000B2 (en) 2015-09-02 2020-06-30 Metronom Health, Inc. Systems and methods for continuous health monitoring using an opto-enzymatic analyte sensor
CN109725065A (zh) * 2017-10-31 2019-05-07 中国石油化工股份有限公司 一种轻质油中硫醇类化合物的分析方法
CN113237988B (zh) * 2021-04-30 2021-12-31 北京济圣康泰国际医药科技有限公司 一种羟考酮液体制剂中降解杂质羟醛二聚体含量的检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
JP2001505558A (ja) 1996-11-15 2001-04-24 シンソーブ バイオテック，インコーポレイテッド 炭化水素ライブラリーのコンビナトリアル合成
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
EP1456214A2 (en) * 2001-12-14 2004-09-15 Charterhouse Therapeutics Limited Improvements in pharmaceutical compositions
TWI365880B (en) * 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
CN101346384B (zh) * 2005-11-22 2012-07-04 控制化学品公司 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
MX2008010921A (es) * 2006-03-02 2008-09-03 Mallinckrodt Inc Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados.
EP2322926A1 (en) 2009-11-11 2011-05-18 Zedira GmbH Stabilized open form transglutaminase as a diagnostic indicator for autoimmune diseases

Also Published As

Publication number Publication date
CN101346384B (zh) 2012-07-04
MX345055B (es) 2017-01-13
JP2013079279A (ja) 2013-05-02
EP2402346A1 (en) 2012-01-04
US10201174B2 (en) 2019-02-12
CN102816167A (zh) 2012-12-12
CN102816167B (zh) 2016-01-06
CA2630703A1 (en) 2007-05-31
KR20150041176A (ko) 2015-04-15
US20070149559A1 (en) 2007-06-28
CA2630703C (en) 2014-05-20
US20170027199A1 (en) 2017-02-02
JP2009516750A (ja) 2009-04-23
WO2007062184A2 (en) 2007-05-31
US9034893B2 (en) 2015-05-19
US20150148537A1 (en) 2015-05-28
CN101346384A (zh) 2009-01-14
US7875623B2 (en) 2011-01-25
US20110136849A1 (en) 2011-06-09
KR101561760B1 (ko) 2015-10-20
US9403838B2 (en) 2016-08-02
KR20140002807A (ko) 2014-01-08
KR20080096750A (ko) 2008-11-03
AU2006318445A1 (en) 2007-05-31
KR101417135B1 (ko) 2014-07-08
MX2008006710A (es) 2008-12-16
WO2007062184A3 (en) 2007-07-26
EP1971607A2 (en) 2008-09-24
HK1179622A1 (zh) 2013-10-04

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