MX345055B - Procedimientos para reducir niveles de aceptor de michael contaminantes en oxicodona y otras composiciones. - Google Patents

Procedimientos para reducir niveles de aceptor de michael contaminantes en oxicodona y otras composiciones.

Info

Publication number
MX345055B
MX345055B MX2012006612A MX2012006612A MX345055B MX 345055 B MX345055 B MX 345055B MX 2012006612 A MX2012006612 A MX 2012006612A MX 2012006612 A MX2012006612 A MX 2012006612A MX 345055 B MX345055 B MX 345055B
Authority
MX
Mexico
Prior art keywords
processes
compositions
oxycodone
michael acceptor
michael
Prior art date
Application number
MX2012006612A
Other languages
English (en)
Inventor
Jules A Shafer
Vladislav V Telyatnikov
Hao Wang
Original Assignee
Controlled Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Controlled Chemicals Inc filed Critical Controlled Chemicals Inc
Publication of MX345055B publication Critical patent/MX345055B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cleaning Or Drying Semiconductors (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

La presente invención se refiere a procedimientos para remover aceptores de Michael a partir de ciertas composiciones en donde la composición se trata con un compuesto que contiene tiol bajo condiciones suficientes para remover aceptores de Michael y los tiol-aductos de Michael resultantes; ciertas modalidades de la presente invención permiten la cuantificación y/o remoción de aceptores de Michael y/o precursores de aceptor de Michael.
MX2012006612A 2005-11-22 2008-05-22 Procedimientos para reducir niveles de aceptor de michael contaminantes en oxicodona y otras composiciones. MX345055B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73908705P 2005-11-22 2005-11-22

Publications (1)

Publication Number Publication Date
MX345055B true MX345055B (es) 2017-01-13

Family

ID=38042645

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2008006710A MX2008006710A (es) 2005-11-22 2006-11-22 Procedimientos para reducir niveles de aceptor de michael contaminantes en oxicodona y otras composiciones.
MX2012006612A MX345055B (es) 2005-11-22 2008-05-22 Procedimientos para reducir niveles de aceptor de michael contaminantes en oxicodona y otras composiciones.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2008006710A MX2008006710A (es) 2005-11-22 2006-11-22 Procedimientos para reducir niveles de aceptor de michael contaminantes en oxicodona y otras composiciones.

Country Status (9)

Country Link
US (4) US7875623B2 (es)
EP (2) EP2402346A1 (es)
JP (2) JP5415075B2 (es)
KR (3) KR101417135B1 (es)
CN (2) CN101346384B (es)
CA (1) CA2630703C (es)
HK (1) HK1179622A1 (es)
MX (2) MX2008006710A (es)
WO (1) WO2007062184A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3175780A1 (en) 2003-12-18 2017-06-07 Metronom Health, Inc. Implantable biosensor and methods of use thereof
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
EP2402346A1 (en) 2005-11-22 2012-01-04 Controlled Chemicals, Inc. Processes for reducing contaminating Michael acceptor levels in oxycodone and other compositions
JP5695296B2 (ja) * 2006-03-02 2015-04-01 マリンクロッド エルエルシー 低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
CA2671551C (en) 2006-12-04 2015-02-10 Noramco, Inc. Process for reducing impurities in oxycodone base
CA2671518C (en) 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
FR2923484B1 (fr) * 2007-11-09 2012-11-09 Sanofi Aventis Procede de preparation de composes morphiniques
WO2012003468A1 (en) 2010-07-02 2012-01-05 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
WO2014022733A1 (en) 2012-08-03 2014-02-06 Johnson Matthey Public Limited Company A method for preparing oxycodone
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
CA2954600A1 (en) 2014-07-09 2016-01-14 Rhodes Technologies Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions
WO2017040849A1 (en) 2015-09-02 2017-03-09 Bremer Troy M Systems and methods for continuous health monitoring using an opto-enzymatic analyte sensor
CN109725065A (zh) * 2017-10-31 2019-05-07 中国石油化工股份有限公司 一种轻质油中硫醇类化合物的分析方法
CN113237988B (zh) * 2021-04-30 2021-12-31 北京济圣康泰国际医药科技有限公司 一种羟考酮液体制剂中降解杂质羟醛二聚体含量的检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
WO1998022487A1 (en) 1996-11-15 1998-05-28 Synsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
AU2002352402A1 (en) * 2001-12-14 2003-06-30 Charterhouse Therapeutics Limited Improvements in pharmaceutical compositions
TW201509943A (zh) * 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
EP2402346A1 (en) * 2005-11-22 2012-01-04 Controlled Chemicals, Inc. Processes for reducing contaminating Michael acceptor levels in oxycodone and other compositions
JP5695296B2 (ja) * 2006-03-02 2015-04-01 マリンクロッド エルエルシー 低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
EP2322926A1 (en) 2009-11-11 2011-05-18 Zedira GmbH Stabilized open form transglutaminase as a diagnostic indicator for autoimmune diseases

Also Published As

Publication number Publication date
MX2008006710A (es) 2008-12-16
CN101346384A (zh) 2009-01-14
JP2009516750A (ja) 2009-04-23
EP1971607A2 (en) 2008-09-24
CA2630703C (en) 2014-05-20
EP2402346A1 (en) 2012-01-04
CN101346384B (zh) 2012-07-04
CN102816167A (zh) 2012-12-12
US10201174B2 (en) 2019-02-12
CN102816167B (zh) 2016-01-06
KR20140002807A (ko) 2014-01-08
WO2007062184A2 (en) 2007-05-31
CA2630703A1 (en) 2007-05-31
US9034893B2 (en) 2015-05-19
JP2013079279A (ja) 2013-05-02
US7875623B2 (en) 2011-01-25
AU2006318445A1 (en) 2007-05-31
US20150148537A1 (en) 2015-05-28
KR20150041176A (ko) 2015-04-15
US9403838B2 (en) 2016-08-02
US20070149559A1 (en) 2007-06-28
HK1179622A1 (zh) 2013-10-04
KR20080096750A (ko) 2008-11-03
KR101561760B1 (ko) 2015-10-20
KR101417135B1 (ko) 2014-07-08
US20170027199A1 (en) 2017-02-02
WO2007062184A3 (en) 2007-07-26
JP5415075B2 (ja) 2014-02-12
US20110136849A1 (en) 2011-06-09

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