KR101516289B1 - 간세포 성장 인자에 대한 사람화된 모노클로날 항체 - Google Patents

간세포 성장 인자에 대한 사람화된 모노클로날 항체 Download PDF

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Publication number
KR101516289B1
KR101516289B1 KR1020087026853A KR20087026853A KR101516289B1 KR 101516289 B1 KR101516289 B1 KR 101516289B1 KR 1020087026853 A KR1020087026853 A KR 1020087026853A KR 20087026853 A KR20087026853 A KR 20087026853A KR 101516289 B1 KR101516289 B1 KR 101516289B1
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KR20090013777A (ko
Inventor
경 진 김
리홍 왕
한 길 박
막시밀리아노 바스퀴즈
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갤럭시 바이오테크, 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020087026853A 2006-04-01 2007-03-28 간세포 성장 인자에 대한 사람화된 모노클로날 항체 Expired - Fee Related KR101516289B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78824306P 2006-04-01 2006-04-01
US60/788,243 2006-04-01
PCT/US2007/065385 WO2007115049A2 (en) 2006-04-01 2007-03-28 Humanized monoclonal antibodies to hepatocyte growth factor

Publications (2)

Publication Number Publication Date
KR20090013777A KR20090013777A (ko) 2009-02-05
KR101516289B1 true KR101516289B1 (ko) 2015-05-07

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KR1020087026853A Expired - Fee Related KR101516289B1 (ko) 2006-04-01 2007-03-28 간세포 성장 인자에 대한 사람화된 모노클로날 항체

Country Status (25)

Country Link
US (3) US7632926B2 (enExample)
EP (2) EP2016162B1 (enExample)
JP (1) JP5312315B2 (enExample)
KR (1) KR101516289B1 (enExample)
CN (2) CN103172736A (enExample)
AR (1) AR059922A1 (enExample)
AU (1) AU2007233242B2 (enExample)
BR (1) BRPI0709932A2 (enExample)
CA (1) CA2645358C (enExample)
CO (1) CO6140067A2 (enExample)
CR (1) CR10308A (enExample)
ES (1) ES2465668T3 (enExample)
GE (1) GEP20125517B (enExample)
IL (1) IL194221A (enExample)
MA (1) MA30382B1 (enExample)
MX (1) MX2008012619A (enExample)
MY (1) MY145042A (enExample)
NO (1) NO20084539L (enExample)
NZ (1) NZ571132A (enExample)
PE (1) PE20080008A1 (enExample)
RU (1) RU2461570C2 (enExample)
TW (1) TWI417300B (enExample)
UA (1) UA94452C2 (enExample)
WO (1) WO2007115049A2 (enExample)
ZA (1) ZA200807903B (enExample)

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US20040208876A1 (en) * 2003-04-18 2004-10-21 Kim Kyung Jin Monoclonal antibodies to hepatocyte growth factor
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AR059922A1 (es) 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
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JP2011513427A (ja) * 2008-03-06 2011-04-28 ジェネンテック， インコーポレイテッド ｃ−ｍｅｔ及びＥＧＦＲアンタゴニストの併用療法
EP2636513B1 (en) * 2008-04-10 2014-08-27 Stratasys Ltd. System and method for three dimensional model printing
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WO2009126840A1 (en) * 2008-04-11 2009-10-15 Galaxy Biotech, Llc Combination of hgf inhibitor and hedgehog inhibitor to treat cancer
TW200948380A (en) * 2008-04-11 2009-12-01 Galaxy Biotech Llc Combination of HGF inhibitor and PTEN agonist to treat cancer
JP5699075B2 (ja) * 2008-05-14 2015-04-08 アムジエン・インコーポレーテツド 癌の治療のためのｖｅｇｆ（ｒ）阻害剤および肝細胞増殖因子（ｃ−ｍｅｔ）阻害剤との組合せ
US8101725B2 (en) 2008-05-29 2012-01-24 Galaxy Biotech, Llc Monoclonal antibodies to basic fibroblast growth factor
CN102316897B (zh) 2008-07-08 2014-11-05 昂考梅德药品有限公司 Notch结合剂和拮抗剂及其应用方法
US8834875B2 (en) 2010-01-13 2014-09-16 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
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US9732150B2 (en) 2013-03-14 2017-08-15 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
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EP4013869A1 (en) 2019-08-12 2022-06-22 InteRNA Technologies B.V. New treatments involving mirna-193a
CN115461461A (zh) 2020-02-28 2022-12-09 因特尔纳技术有限公司 用于促进免疫原性细胞死亡的miRNA-193a
CN113980129B (zh) * 2021-01-15 2023-07-28 东大生物技术(苏州)有限公司 一组il-11单克隆抗体及其医药用途
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Also Published As

Publication number Publication date
US20080019974A1 (en) 2008-01-24
US20140335076A1 (en) 2014-11-13
BRPI0709932A2 (pt) 2011-08-02
NO20084539L (no) 2008-10-28
JP2009532378A (ja) 2009-09-10
CN101415811A (zh) 2009-04-22
WO2007115049A2 (en) 2007-10-11
CO6140067A2 (es) 2010-03-19
NZ571132A (en) 2012-05-25
WO2007115049A3 (en) 2008-09-04
CR10308A (es) 2008-10-27
EP2476704A3 (en) 2012-07-25
US20100278815A1 (en) 2010-11-04
EP2476704A2 (en) 2012-07-18
ES2465668T3 (es) 2014-06-06
EP2016162A4 (en) 2009-11-11
RU2461570C2 (ru) 2012-09-20
US8628778B2 (en) 2014-01-14
AU2007233242B2 (en) 2012-04-26
CA2645358C (en) 2015-05-05
CN103172736A (zh) 2013-06-26
TW200808828A (en) 2008-02-16
MY145042A (en) 2011-12-15
MA30382B1 (fr) 2009-05-04
HK1121489A1 (en) 2009-04-24
ZA200807903B (en) 2010-03-31
AU2007233242A1 (en) 2007-10-11
UA94452C2 (ru) 2011-05-10
US7632926B2 (en) 2009-12-15
JP5312315B2 (ja) 2013-10-09
EP2016162A2 (en) 2009-01-21
PE20080008A1 (es) 2008-02-14
TWI417300B (zh) 2013-12-01
AR059922A1 (es) 2008-05-07
MX2008012619A (es) 2008-10-13
KR20090013777A (ko) 2009-02-05
CA2645358A1 (en) 2007-10-11
CN101415811B (zh) 2013-01-30
GEP20125517B (en) 2012-05-25
RU2008143318A (ru) 2010-05-10
EP2016162B1 (en) 2014-04-16
IL194221A (en) 2015-11-30

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