TWI417300B - 與肝細胞生長因子結合之人化單株抗體類 - Google Patents

與肝細胞生長因子結合之人化單株抗體類 Download PDF

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Publication number
TWI417300B
TWI417300B TW096111376A TW96111376A TWI417300B TW I417300 B TWI417300 B TW I417300B TW 096111376 A TW096111376 A TW 096111376A TW 96111376 A TW96111376 A TW 96111376A TW I417300 B TWI417300 B TW I417300B
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TW
Taiwan
Prior art keywords
hgf
monoclonal antibody
humanized
amino acid
human
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TW096111376A
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English (en)
Chinese (zh)
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TW200808828A (en
Inventor
Kyung Jin Kim
Lihong Wang
Hangil Park
Maximiliano Vasquez
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Galaxy Biotech Llc
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Publication of TW200808828A publication Critical patent/TW200808828A/zh
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Publication of TWI417300B publication Critical patent/TWI417300B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW096111376A 2006-04-01 2007-03-30 與肝細胞生長因子結合之人化單株抗體類 TWI417300B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78824306P 2006-04-01 2006-04-01

Publications (2)

Publication Number Publication Date
TW200808828A TW200808828A (en) 2008-02-16
TWI417300B true TWI417300B (zh) 2013-12-01

Family

ID=38564195

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096111376A TWI417300B (zh) 2006-04-01 2007-03-30 與肝細胞生長因子結合之人化單株抗體類

Country Status (25)

Country Link
US (3) US7632926B2 (enExample)
EP (2) EP2476704A3 (enExample)
JP (1) JP5312315B2 (enExample)
KR (1) KR101516289B1 (enExample)
CN (2) CN101415811B (enExample)
AR (1) AR059922A1 (enExample)
AU (1) AU2007233242B2 (enExample)
BR (1) BRPI0709932A2 (enExample)
CA (1) CA2645358C (enExample)
CO (1) CO6140067A2 (enExample)
CR (1) CR10308A (enExample)
ES (1) ES2465668T3 (enExample)
GE (1) GEP20125517B (enExample)
IL (1) IL194221A (enExample)
MA (1) MA30382B1 (enExample)
MX (1) MX2008012619A (enExample)
MY (1) MY145042A (enExample)
NO (1) NO20084539L (enExample)
NZ (1) NZ571132A (enExample)
PE (1) PE20080008A1 (enExample)
RU (1) RU2461570C2 (enExample)
TW (1) TWI417300B (enExample)
UA (1) UA94452C2 (enExample)
WO (1) WO2007115049A2 (enExample)
ZA (1) ZA200807903B (enExample)

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US7649083B2 (en) 2006-06-02 2010-01-19 Aveo Pharmaceuticals, Inc. Hepatocyte growth factor (HGF) binding antibody
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DK3290052T3 (da) 2008-11-07 2020-02-03 Galaxy Biotech Llc Monoklonale antistoffer mod fibroblastvækstfaktorreceptor 2
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US9062104B2 (en) 2013-03-14 2015-06-23 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
TW201444868A (zh) * 2013-03-14 2014-12-01 Alder Biopharmaceuticals Inc Ｈｇｆ抗體及其組成物
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AU2020327537A1 (en) 2019-08-12 2022-03-03 Interna Technologies B.V. New treatments involving miRNA-193a
KR20220082007A (ko) 2019-10-08 2022-06-16 넥틴 테라퓨틱스 리미티드 폴리오바이러스 수용체(pvr)에 대한 항체 및 이의 용도
US20230136088A1 (en) 2020-02-28 2023-05-04 Interna Technologies B.V. miRNA-193a for Promoting Immunogenic Cell Death
CN113980129B (zh) * 2021-01-15 2023-07-28 东大生物技术(苏州)有限公司 一组il-11单克隆抗体及其医药用途
CN119285785B (zh) * 2024-09-26 2025-04-18 武汉奥科博泰生物科技有限公司 一种抗d-二聚体单克隆抗体及其应用

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Also Published As

Publication number Publication date
CN103172736A (zh) 2013-06-26
AR059922A1 (es) 2008-05-07
NO20084539L (no) 2008-10-28
US20080019974A1 (en) 2008-01-24
JP5312315B2 (ja) 2013-10-09
RU2461570C2 (ru) 2012-09-20
MA30382B1 (fr) 2009-05-04
WO2007115049A2 (en) 2007-10-11
BRPI0709932A2 (pt) 2011-08-02
US20100278815A1 (en) 2010-11-04
HK1121489A1 (en) 2009-04-24
JP2009532378A (ja) 2009-09-10
CA2645358C (en) 2015-05-05
AU2007233242A1 (en) 2007-10-11
CA2645358A1 (en) 2007-10-11
KR20090013777A (ko) 2009-02-05
TW200808828A (en) 2008-02-16
CO6140067A2 (es) 2010-03-19
ZA200807903B (en) 2010-03-31
US8628778B2 (en) 2014-01-14
CN101415811A (zh) 2009-04-22
AU2007233242B2 (en) 2012-04-26
CN101415811B (zh) 2013-01-30
US20140335076A1 (en) 2014-11-13
MY145042A (en) 2011-12-15
MX2008012619A (es) 2008-10-13
UA94452C2 (ru) 2011-05-10
NZ571132A (en) 2012-05-25
EP2016162A4 (en) 2009-11-11
ES2465668T3 (es) 2014-06-06
EP2016162A2 (en) 2009-01-21
CR10308A (es) 2008-10-27
EP2476704A2 (en) 2012-07-18
PE20080008A1 (es) 2008-02-14
US7632926B2 (en) 2009-12-15
IL194221A (en) 2015-11-30
GEP20125517B (en) 2012-05-25
RU2008143318A (ru) 2010-05-10
KR101516289B1 (ko) 2015-05-07
WO2007115049A3 (en) 2008-09-04
EP2016162B1 (en) 2014-04-16
EP2476704A3 (en) 2012-07-25

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