KR101504640B1 - 광절단가능 표지된 뉴클레오티드와 뉴클레오시드, 표지된 뉴클레오티드와 뉴클레오시드, 그리고 ｄｎａ 염기서열분석에서 이들의 이용 방법 - Google Patents

광절단가능 표지된 뉴클레오티드와 뉴클레오시드, 표지된 뉴클레오티드와 뉴클레오시드, 그리고 ｄｎａ 염기서열분석에서 이들의 이용 방법 Download PDF

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KR101504640B1
KR101504640B1 KR1020097013028A KR20097013028A KR101504640B1 KR 101504640 B1 KR101504640 B1 KR 101504640B1 KR 1020097013028 A KR1020097013028 A KR 1020097013028A KR 20097013028 A KR20097013028 A KR 20097013028A KR 101504640 B1 KR101504640 B1 KR 101504640B1
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mmol
compound according
compound
triphosphate
nucleic acid
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KR20090101451A (ko
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블라디슬라브 에이. 리토시
브라이언 피. 스투피
마이클 엘. 메츠케르
웨이동 우
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레이저젠, 인코퍼레이티드
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Priority claimed from US11/567,189 external-priority patent/US7897737B2/en
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Assigned to 애질런트 테크놀로지스, 인크. reassignment 애질런트 테크놀로지스, 인크. 권리의 전부이전등록 Assignors: 레이저젠, 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
KR1020097013028A 2006-12-05 2007-12-05 광절단가능 표지된 뉴클레오티드와 뉴클레오시드, 표지된 뉴클레오티드와 뉴클레오시드, 그리고 ｄｎａ 염기서열분석에서 이들의 이용 방법 Active KR101504640B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/567,193 US7893227B2 (en) 2006-12-05 2006-12-05 3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing
US11/567,189 2006-12-05
US11/567,189 US7897737B2 (en) 2006-12-05 2006-12-05 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US11/567,193 2006-12-05
PCT/US2007/086559 WO2008070749A2 (en) 2006-12-05 2007-12-05 Photocleavable labeled nucleotides and nucleosides and labeled nucleotides and nucleosides and methods for their use in dna sequencing

Publications (2)

Publication Number Publication Date
KR20090101451A KR20090101451A (ko) 2009-09-28
KR101504640B1 true KR101504640B1 (ko) 2015-03-20

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KR1020097013028A Active KR101504640B1 (ko) 2006-12-05 2007-12-05 광절단가능 표지된 뉴클레오티드와 뉴클레오시드, 표지된 뉴클레오티드와 뉴클레오시드, 그리고 ｄｎａ 염기서열분석에서 이들의 이용 방법

Country Status (12)

Country Link
EP (1) EP2125856B1 (https=)
JP (1) JP5513122B2 (https=)
KR (1) KR101504640B1 (https=)
CN (1) CN102443030B (https=)
AU (1) AU2007329361B2 (https=)
BR (1) BRPI0719923B1 (https=)
CA (1) CA2670937C (https=)
IL (1) IL199051A (https=)
MX (2) MX338089B (https=)
NZ (1) NZ577303A (https=)
RU (1) RU2009121089A (https=)
WO (1) WO2008070749A2 (https=)

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US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
NZ590265A (en) 2008-06-11 2012-11-30 Lasergen Inc Nucleotides and nucleosides and methods for their use in dna sequencing
EP2321429B1 (en) 2008-09-03 2016-08-17 Quantumdx Group Limited Methods and kits for nucleic acid sequencing
US10759824B2 (en) 2008-09-03 2020-09-01 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising charge mass tags
WO2013040257A1 (en) 2011-09-13 2013-03-21 Lasergen, Inc. 5-methoxy. 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
WO2013105025A1 (en) * 2012-01-13 2013-07-18 Koninklijke Philips N.V. Dna sequencing with reagent recycling on wiregrid
CN103602719B (zh) * 2013-04-07 2016-06-08 北京迈基诺基因科技有限责任公司 一种基因测序方法
WO2015015913A1 (ja) * 2013-07-31 2015-02-05 株式会社 日立ハイテクノロジーズ 核酸分析用フローセル、及び核酸分析装置
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
RU2582198C1 (ru) * 2014-11-20 2016-04-20 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделения Российской академии наук (ЛИН СО РАН) Аналоги природных дезоксирибонуклеозидтрифосфатов и рибонуклеозидтрифосфатов, содержащие репортёрные флуоресцентные группы, для использования в аналитической биоорганической химии
CN105001292A (zh) * 2015-07-14 2015-10-28 深圳市瀚海基因生物科技有限公司 一种光可断裂的荧光标记可逆终端化合物及其在dna或rna测序中的用途
EP3400444A4 (en) 2016-01-04 2019-10-16 QuantuMDx Group Limited DESIGN, SYNTHESIS AND USE OF SYNTHETIC NUCLEOTIDES WITH LOADING MASS MARKINGS
GB201711219D0 (en) 2017-07-12 2017-08-23 Illumina Cambridge Ltd Short pendant arm linkers for nucleotides in sequencing applications
CN113272443B (zh) 2019-01-07 2025-01-10 安捷伦科技有限公司 用于单细胞中的基因组dna和基因表达分析的组合物和方法
CN110568039B (zh) * 2019-09-06 2021-05-04 中国科学院生物物理研究所 使用新型电化学传感器的氨基酸特异实时检测方法
WO2021194640A1 (en) * 2020-03-26 2021-09-30 Agilent Technologies, Inc. Methods and compositions for multistage primer extension reactions
GB2605404A (en) * 2021-03-30 2022-10-05 Sumitomo Chemical Co Sequencing method
WO2022263489A1 (en) * 2021-06-17 2022-12-22 F. Hoffmann-La Roche Ag Nucleoside-5 -oligophosphates having a cationically-modified nucleobase
IL309368A (en) * 2021-06-29 2024-02-01 Agilent Technologies Inc polymerase mutants and use with 3'-OH UNBLOCKED REVERSIBLE TERMINATORS
CN114250283B (zh) * 2021-10-15 2022-10-04 深圳铭毅智造科技有限公司 基于环境敏感染料的单色荧光mrt基因测序试剂及方法

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WO2004018493A1 (en) 2002-08-23 2004-03-04 Solexa Limited Labelled nucleotides
WO2005084367A2 (en) * 2004-03-03 2005-09-15 The Trustees Of Columbia University In The City Of New York Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry

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WO2004018493A1 (en) 2002-08-23 2004-03-04 Solexa Limited Labelled nucleotides
WO2005084367A2 (en) * 2004-03-03 2005-09-15 The Trustees Of Columbia University In The City Of New York Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry

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Also Published As

Publication number Publication date
IL199051A (en) 2013-11-28
AU2007329361A1 (en) 2008-06-12
JP5513122B2 (ja) 2014-06-04
CA2670937C (en) 2016-07-26
RU2009121089A (ru) 2011-01-20
MX338089B (es) 2016-04-01
CN102443030A (zh) 2012-05-09
BRPI0719923A2 (pt) 2014-03-04
EP2125856A2 (en) 2009-12-02
CN102443030B (zh) 2015-12-16
AU2007329361B2 (en) 2013-07-18
CA2670937A1 (en) 2008-06-12
BRPI0719923B1 (pt) 2021-08-17
MX2009005936A (es) 2010-01-15
WO2008070749A2 (en) 2008-06-12
JP2011506265A (ja) 2011-03-03
HK1169413A1 (zh) 2013-01-25
EP2125856B1 (en) 2016-09-14
NZ577303A (en) 2011-12-22
WO2008070749A3 (en) 2008-11-27
KR20090101451A (ko) 2009-09-28
EP2125856A4 (en) 2013-12-25

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