KR101395591B1 - 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기 방법의 중간체 - Google Patents

고리화된 피페라진-2-온 유도체의 제조 방법 및 상기 방법의 중간체 Download PDF

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KR101395591B1
KR101395591B1 KR1020127028659A KR20127028659A KR101395591B1 KR 101395591 B1 KR101395591 B1 KR 101395591B1 KR 1020127028659 A KR1020127028659 A KR 1020127028659A KR 20127028659 A KR20127028659 A KR 20127028659A KR 101395591 B1 KR101395591 B1 KR 101395591B1
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KR20120136414A (ko
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아딜 듀란
귄터 린츠
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베링거 인겔하임 인터내셔날 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020127028659A 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기 방법의 중간체 Expired - Fee Related KR101395591B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004058337A DE102004058337A1 (de) 2004-12-02 2004-12-02 Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
DE102004058337.4 2004-12-02
PCT/EP2005/056291 WO2006058876A1 (de) 2004-12-02 2005-11-29 Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020077015136A Division KR101362131B1 (ko) 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기방법의 중간체

Publications (2)

Publication Number Publication Date
KR20120136414A KR20120136414A (ko) 2012-12-18
KR101395591B1 true KR101395591B1 (ko) 2014-05-16

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KR1020127028659A Expired - Fee Related KR101395591B1 (ko) 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기 방법의 중간체
KR1020077015136A Expired - Fee Related KR101362131B1 (ko) 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기방법의 중간체

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Country Status (34)

Country Link
US (9) US7238807B2 (https=)
EP (2) EP1819706B1 (https=)
JP (1) JP5164574B2 (https=)
KR (2) KR101395591B1 (https=)
CN (3) CN101065381B (https=)
AR (1) AR053100A1 (https=)
AU (1) AU2005311308B2 (https=)
BR (1) BRPI0518601A2 (https=)
CA (1) CA2588857C (https=)
CL (1) CL2013002895A1 (https=)
CY (1) CY1113625T1 (https=)
DE (1) DE102004058337A1 (https=)
DK (2) DK1819706T3 (https=)
EA (1) EA012624B1 (https=)
ES (2) ES2548680T3 (https=)
HR (1) HRP20120980T1 (https=)
HU (1) HUE027689T2 (https=)
IL (1) IL183568A (https=)
ME (1) ME01470B (https=)
MX (1) MX2007006549A (https=)
MY (1) MY147459A (https=)
NO (1) NO20072283L (https=)
NZ (1) NZ556182A (https=)
PE (2) PE20061061A1 (https=)
PL (2) PL2436685T3 (https=)
PT (1) PT1819706E (https=)
RS (1) RS52533B (https=)
SG (2) SG158848A1 (https=)
SI (1) SI1819706T1 (https=)
TW (1) TWI362391B (https=)
UA (1) UA89390C2 (https=)
UY (1) UY29233A1 (https=)
WO (1) WO2006058876A1 (https=)
ZA (1) ZA200703368B (https=)

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US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
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US7759485B2 (en) * 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en) * 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
TW200804389A (en) 2006-02-14 2008-01-16 Vertex Pharma Dihydrodiazepines useful as inhibitors of protein kinases
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EP2185559A1 (en) * 2007-08-03 2010-05-19 Boehringer Ingelheim International GmbH Crystalline form of a dihydropteridione derivative
EP2100894A1 (en) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
CA2773827A1 (en) 2009-09-25 2011-03-31 Vertex Pharmaceuticals Incorporated Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
SG179206A1 (en) 2009-09-25 2012-04-27 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
CA2827770A1 (en) 2011-02-25 2012-11-01 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
TW201414734A (zh) 2012-07-10 2014-04-16 Takeda Pharmaceutical 氮雜吲哚衍生物
US20150031699A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
AR099052A1 (es) 2014-01-09 2016-06-29 Takeda Pharmaceuticals Co Derivados de azaindol
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome

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Also Published As

Publication number Publication date
HUE027689T2 (hu) 2021-12-28
UY29233A1 (es) 2006-07-31
US20070213530A1 (en) 2007-09-13
AR053100A1 (es) 2007-04-25
US20070213528A1 (en) 2007-09-13
MY147459A (en) 2012-12-14
PE20061061A1 (es) 2006-11-10
ME01470B (me) 2014-04-20
KR20070092252A (ko) 2007-09-12
DK1819706T3 (da) 2013-01-02
EP1819706B1 (de) 2012-09-19
UA89390C2 (ru) 2010-01-25
CN101065381A (zh) 2007-10-31
EP2436685B1 (de) 2015-07-01
CN102093361B (zh) 2014-05-07
TW200628471A (en) 2006-08-16
ES2548680T3 (es) 2015-10-20
CY1113625T1 (el) 2016-06-22
NZ556182A (en) 2009-08-28
CL2013002895A1 (es) 2014-03-14
PL2436685T3 (pl) 2015-11-30
SG141461A1 (en) 2008-04-28
RS52533B (sr) 2013-04-30
AU2005311308A1 (en) 2006-06-08
HK1158200A1 (en) 2012-07-13
USRE43115E1 (en) 2012-01-17
CN102070637B (zh) 2012-09-26
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JP5164574B2 (ja) 2013-03-21
JP2008521861A (ja) 2008-06-26
SG158848A1 (en) 2010-02-26
ES2395829T3 (es) 2013-02-15
DE102004058337A1 (de) 2006-06-14
PT1819706E (pt) 2012-12-06
PL1819706T3 (pl) 2013-03-29
EA200701164A1 (ru) 2007-12-28
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US20070213531A1 (en) 2007-09-13
US7238807B2 (en) 2007-07-03
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SI1819706T1 (sl) 2013-01-31
BRPI0518601A2 (pt) 2008-11-25
ZA200703368B (en) 2008-09-25
PE20090488A1 (es) 2009-05-27
EP2436685A1 (de) 2012-04-04
WO2006058876A1 (de) 2006-06-08
CA2588857C (en) 2013-10-08
CN101065381B (zh) 2011-03-30
CN102070637A (zh) 2011-05-25
EA012624B1 (ru) 2009-10-30
US20060122393A1 (en) 2006-06-08
US7626019B2 (en) 2009-12-01
IL183568A (en) 2015-02-26
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US20070213529A1 (en) 2007-09-13
US20070219369A1 (en) 2007-09-20
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AU2005311308B2 (en) 2012-04-12
NO20072283L (no) 2007-06-28
TWI362391B (en) 2012-04-21
MX2007006549A (es) 2007-06-18
US20070208027A1 (en) 2007-09-06
KR101362131B1 (ko) 2014-02-19
CN102093361A (zh) 2011-06-15
KR20120136414A (ko) 2012-12-18
HK1113489A1 (en) 2008-10-03
EP1819706A1 (de) 2007-08-22

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