KR101385050B1 - 식물에서 당단백질 생산의 변형 - Google Patents

식물에서 당단백질 생산의 변형 Download PDF

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Publication number
KR101385050B1
KR101385050B1 KR1020107000811A KR20107000811A KR101385050B1 KR 101385050 B1 KR101385050 B1 KR 101385050B1 KR 1020107000811 A KR1020107000811 A KR 1020107000811A KR 20107000811 A KR20107000811 A KR 20107000811A KR 101385050 B1 KR101385050 B1 KR 101385050B1
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South Korea
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protein
plant
interest
nucleotide sequence
galt
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Korean (ko)
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KR20100037602A (ko
Inventor
마르크-안드레 다우스트
에스텔르 마르케-블륀
뮤리엘 바르도
카롤 부렐
로익 파이
패트리스 르루즈
루이스-필리페 베지나
베로니크 고모
스테파니 아퀸
크리스토프 리후이
토마스 파칼레
크리스토프 소르일레
Original Assignee
메디카고 인코포레이티드
유니베르시떼 드 루앙
상뜨르 나시오날 드 라 리쉐르쉐 샹띠피끄
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Cultivation Of Plants (AREA)
KR1020107000811A 2007-06-15 2008-06-13 식물에서 당단백질 생산의 변형 Expired - Fee Related KR101385050B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94434407P 2007-06-15 2007-06-15
US60/944,344 2007-06-15
PCT/CA2008/001139 WO2008151440A1 (en) 2007-06-15 2008-06-13 Modifying glycoprotein production in plants

Related Child Applications (1)

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KR1020137014893A Division KR20130075787A (ko) 2007-06-15 2008-06-13 식물에서 당단백질 생산의 변형

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KR20100037602A KR20100037602A (ko) 2010-04-09
KR101385050B1 true KR101385050B1 (ko) 2014-05-13

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KR1020107000811A Expired - Fee Related KR101385050B1 (ko) 2007-06-15 2008-06-13 식물에서 당단백질 생산의 변형
KR1020137014893A Ceased KR20130075787A (ko) 2007-06-15 2008-06-13 식물에서 당단백질 생산의 변형

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KR1020137014893A Ceased KR20130075787A (ko) 2007-06-15 2008-06-13 식물에서 당단백질 생산의 변형

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Country Link
US (1) US20110008837A1 (enExample)
EP (1) EP2155880B1 (enExample)
JP (1) JP5783720B2 (enExample)
KR (2) KR101385050B1 (enExample)
CN (3) CN104962579A (enExample)
AU (1) AU2008261527C1 (enExample)
BR (1) BRPI0812538B1 (enExample)
CA (2) CA2700180C (enExample)
DK (1) DK2155880T3 (enExample)
EG (1) EG26600A (enExample)
ES (1) ES2624776T3 (enExample)
HU (1) HUE031698T2 (enExample)
IL (1) IL202568A (enExample)
MA (1) MA31516B1 (enExample)
MX (1) MX2009013665A (enExample)
NZ (2) NZ581944A (enExample)
PL (1) PL2155880T3 (enExample)
PT (1) PT2155880T (enExample)
RU (2) RU2499053C2 (enExample)
SG (1) SG185249A1 (enExample)
SI (1) SI2155880T1 (enExample)
TN (1) TN2009000512A1 (enExample)
WO (1) WO2008151440A1 (enExample)
ZA (1) ZA201000207B (enExample)

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CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CN103122354B (zh) 2007-11-27 2018-03-23 麦迪卡格公司 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
ES2545607T3 (es) 2008-07-08 2015-09-14 Medicago Inc. Antígenos de la gripe recombinantes solubles
ES2593277T3 (es) 2008-07-18 2016-12-07 Medicago Inc. Nuevo epítopo de inmunización contra el virus de la influenza
KR101377725B1 (ko) 2009-06-24 2014-03-27 메디카고 인코포레이티드 헤마글루티닌을 포함하는 키메라 인플루엔자 바이러스-유사 입자
BR112012006414B1 (pt) 2009-09-22 2020-09-15 Medicago Inc Métodos para preparação de proteínas derivadas de plantas
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
BR112013031564B1 (pt) * 2011-06-07 2021-11-03 Ibio, Inc Métodos para geração e expressão de um polipeptídio e sistema de expressão
US9181532B2 (en) 2011-07-29 2015-11-10 Icon Genetics Gmbh Production of galactosylated N-glycans in plants
DK2760882T5 (da) 2011-09-30 2024-06-24 Medicago Inc Forøgelse af udbyttet af viruslignende partikler i planter
KR20130125337A (ko) * 2012-05-08 2013-11-18 경상대학교산학협력단 고-만노오스형 n-글라이칸을 생산하는 식물체 및 이를 이용한 고-만노오스형 n-글라이칸의 생산방법
ES2803508T3 (es) 2013-03-28 2021-01-27 Medicago Inc Producción de partículas similares al virus de la gripe en plantas
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
EP3167057B1 (en) 2014-07-11 2020-03-25 Medicago Inc. Modifying protein production in plants
BR112017010555A2 (pt) * 2014-11-20 2018-02-27 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd composições e métodos para produção de polipeptídeos com padrão de glicosilação modificado em células vegetais
EP3548612A4 (en) 2016-12-01 2020-04-15 Plantform Corporation TRANSGENIC PLANT WITH REDUCED FUCOSYL TRANSFERASE AND XYLOSYL TRANSFERASE ACTIVITY
WO2019049111A1 (en) * 2017-09-11 2019-03-14 R. J. Reynolds Tobacco Company METHODS AND COMPOSITIONS FOR INCREASING THE EXPRESSION OF GENES OF INTEREST IN A PLANT BY CO-EXPRESSION WITH P21
WO2022153973A1 (ja) * 2021-01-15 2022-07-21 デンカ株式会社 栽培条件を決定する方法、及び目的タンパク質又は目的ペプチドの製造方法

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WO2003007867A2 (en) 2001-07-18 2003-01-30 Aerophram Technology, Inc. A salt/ion pair medicinal aerosol formulation
WO2004065540A2 (en) 2003-01-22 2004-08-05 Glycart Biotechnology Ag Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function

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Publication number Publication date
DK2155880T3 (en) 2016-12-05
RU2499053C2 (ru) 2013-11-20
IL202568A0 (en) 2011-08-01
CN101918559A (zh) 2010-12-15
CA2700180A1 (en) 2008-12-18
TN2009000512A1 (en) 2011-03-31
CA2700180C (en) 2013-01-29
US20110008837A1 (en) 2011-01-13
MX2009013665A (es) 2010-06-02
PT2155880T (pt) 2016-11-18
EP2155880A1 (en) 2010-02-24
ES2624776T3 (es) 2017-07-17
KR20100037602A (ko) 2010-04-09
RU2013137208A (ru) 2015-02-20
AU2008261527A8 (en) 2010-01-21
KR20130075787A (ko) 2013-07-05
WO2008151440A1 (en) 2008-12-18
EG26600A (en) 2014-03-23
JP2010531136A (ja) 2010-09-24
SG185249A1 (en) 2012-11-29
ZA201000207B (en) 2013-09-25
IL202568A (en) 2015-02-26
MA31516B1 (fr) 2010-07-01
NZ598417A (en) 2013-06-28
WO2008151440A4 (en) 2009-02-26
AU2008261527B8 (en) 2014-04-24
BRPI0812538B1 (pt) 2021-03-16
WO2008151440A8 (en) 2010-03-04
AU2008261527B2 (en) 2014-04-10
AU2008261527C1 (en) 2014-09-04
CN103382487A (zh) 2013-11-06
SI2155880T1 (sl) 2017-03-31
CA2795379A1 (en) 2008-12-18
NZ581944A (en) 2012-03-30
CN104962579A (zh) 2015-10-07
PL2155880T3 (pl) 2017-06-30
EP2155880A4 (en) 2010-08-04
EP2155880B1 (en) 2016-08-10
RU2010101024A (ru) 2011-07-20
BRPI0812538A2 (pt) 2014-09-30
AU2008261527A1 (en) 2008-12-18
JP5783720B2 (ja) 2015-09-24
HUE031698T2 (en) 2017-07-28

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