CN104962579A - 修饰植物中的糖蛋白产生 - Google Patents

修饰植物中的糖蛋白产生 Download PDF

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Publication number
CN104962579A
CN104962579A CN201510364867.XA CN201510364867A CN104962579A CN 104962579 A CN104962579 A CN 104962579A CN 201510364867 A CN201510364867 A CN 201510364867A CN 104962579 A CN104962579 A CN 104962579A
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Prior art keywords
nucleotide sequence
plant
protein
interest
seq
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Chinese (zh)
Inventor
马克-安德烈·德奥斯特
埃斯泰勒·马凯-布卢安
穆里尔·巴尔多
卡罗勒·比雷尔
卢瓦克·法耶
帕特里斯·勒鲁热
路易斯-菲利普·韦齐纳
韦罗妮克·戈莫尔德
斯特凡妮·阿奎
克里斯托夫·里韦
托马斯·帕卡莱特
克里斯托夫·苏鲁耶
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Rouen, University of
Medicago Inc
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Rouen, University of
Medicago Inc
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Publication of CN104962579A publication Critical patent/CN104962579A/zh
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
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  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Cultivation Of Plants (AREA)
CN201510364867.XA 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生 Pending CN104962579A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94434407P 2007-06-15 2007-06-15
US60/944,344 2007-06-15
CN2008801031743A CN101918559A (zh) 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生

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CN2008801031743A Division CN101918559A (zh) 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生

Publications (1)

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CN104962579A true CN104962579A (zh) 2015-10-07

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CN2013101091944A Pending CN103382487A (zh) 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生
CN2008801031743A Pending CN101918559A (zh) 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生
CN201510364867.XA Pending CN104962579A (zh) 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生

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CN2013101091944A Pending CN103382487A (zh) 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生
CN2008801031743A Pending CN101918559A (zh) 2007-06-15 2008-06-13 修饰植物中的糖蛋白产生

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Country Link
US (1) US20110008837A1 (enExample)
EP (1) EP2155880B1 (enExample)
JP (1) JP5783720B2 (enExample)
KR (2) KR20130075787A (enExample)
CN (3) CN103382487A (enExample)
AU (1) AU2008261527C1 (enExample)
BR (1) BRPI0812538B1 (enExample)
CA (2) CA2795379A1 (enExample)
DK (1) DK2155880T3 (enExample)
EG (1) EG26600A (enExample)
ES (1) ES2624776T3 (enExample)
HU (1) HUE031698T2 (enExample)
IL (1) IL202568A (enExample)
MA (1) MA31516B1 (enExample)
MX (1) MX2009013665A (enExample)
NZ (2) NZ581944A (enExample)
PL (1) PL2155880T3 (enExample)
PT (1) PT2155880T (enExample)
RU (2) RU2499053C2 (enExample)
SG (1) SG185249A1 (enExample)
SI (1) SI2155880T1 (enExample)
TN (1) TN2009000512A1 (enExample)
WO (1) WO2008151440A1 (enExample)
ZA (1) ZA201000207B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111328347A (zh) * 2017-09-11 2020-06-23 R.J.雷诺兹烟草公司 通过与p21共表达来增加植物中感兴趣基因的表达的方法和组合物

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
ES2554703T3 (es) 2007-11-27 2015-12-22 Medicago Inc. Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina
CN105753948A (zh) 2008-07-08 2016-07-13 麦迪卡格公司 可溶性重组流感抗原
CA2730668C (en) 2008-07-18 2020-04-28 Medicago Inc. New influenza virus immunizing epitope
EP2445928B1 (en) 2009-06-24 2018-03-28 Medicago Inc. Chimeric influenza virus-like particles comprising hemagglutinin
MX2012003372A (es) 2009-09-22 2012-05-29 Medicago Inc Metodo para preparar proteina derivada de vegetales.
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
CA2839932C (en) * 2011-06-07 2022-07-05 Ibio, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
EP2551348B1 (en) 2011-07-29 2014-09-24 Icon Genetics GmbH Production of galactosylated N-glycans in plants
CN103930435A (zh) 2011-09-30 2014-07-16 麦迪卡格公司 增加植物中病毒样颗粒的产率
WO2013169009A1 (ko) * 2012-05-08 2013-11-14 경상대학교 산학협력단 고-만노오스형 n-글라이칸을 생산하는 식물체 및 이를 이용한 고-만노오스형 n-글라이칸의 생산방법
WO2014153674A1 (en) 2013-03-28 2014-10-02 Medicago Inc. Influenza virus-like particle production in plants
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
US11959088B2 (en) 2014-07-11 2024-04-16 Aramis Biotechnologies Inc. Modifying protein production in plants
EP3221455B1 (en) 2014-11-20 2020-08-12 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
CA3045173A1 (en) 2016-12-01 2018-06-07 Plantform Corporation Transgenic plant with reduced fucosyltransferase and xylosyltransferase activity
US20240057540A1 (en) * 2021-01-15 2024-02-22 Denka Company Limited Method for Determining Conditions for Cultivation, and Method for Producing Desired Protein or Desired Peptide

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029242A2 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
WO2001031044A1 (en) * 1999-10-26 2001-05-03 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Gonadotrophins in plants
CN1377418A (zh) * 1999-10-04 2002-10-30 麦迪卡格公司 用于调控外源基因表达的启动子
CN1549861A (zh) * 2001-01-19 2004-11-24 �Ϻ���ͨ��ѧ 利用植物细胞分泌性生产具有人型糖链的糖蛋白的方法
CN1665934A (zh) * 2002-03-19 2005-09-07 国际植物研究所 GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达
CN1756844A (zh) * 2002-03-19 2006-04-05 国际植物研究所 在植物中优化聚糖生成
CN1761746A (zh) * 2003-01-22 2006-04-19 格黎卡特生物技术股份公司 融合构建体及其用来生产Fc受体结合亲和性和效应子功能提高的抗体的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312746A (en) * 1993-01-08 1994-05-17 Life Technologies, Inc. Cloning and expressing restriction endonucleases and modification methylases from caryophanon
GB9524350D0 (en) * 1995-11-29 1996-01-31 Lynxvale Ltd Enhancer-increased gene expression in plants
US5945326A (en) * 1997-03-20 1999-08-31 New England Biolabs, Inc. Method for cloning and producing the Spel restriction endonuclease
ES2350063T3 (es) * 1998-12-09 2011-01-17 Phyton Holdings, Llc Método para fabricación de glicoproteínas que tienen glicosilación de tipo humano.
US7125978B1 (en) * 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
NZ518532A (en) * 1999-10-26 2004-02-27 Plant Res Internat B Transgenic plant expressing mammalian beta-1,4- galactosyltransferase
US20030035774A1 (en) 2001-07-18 2003-02-20 Adjei Akwete L. Salt/ion pair medicinal aerosol formulation
NZ603111A (en) * 2001-08-03 2014-05-30 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
EP1572910B1 (en) * 2002-02-13 2015-12-02 Wisconsin Alumni Research Foundation Signal for packaging of influenza virus vectors
JP5425365B2 (ja) * 2003-01-22 2014-02-26 グリカート バイオテクノロジー アクチェンゲゼルシャフト 増加したFcレセプター結合親和性およびエフェクター機能を有する抗体を作製するための融合構築物およびその使用
US7132291B2 (en) * 2003-05-05 2006-11-07 Dow Agro Sciences Llc Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
JP2006212019A (ja) * 2004-04-30 2006-08-17 National Institute Of Agrobiological Sciences 植物を用いたユビキノン−10の製造方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1377418A (zh) * 1999-10-04 2002-10-30 麦迪卡格公司 用于调控外源基因表达的启动子
WO2001029242A2 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
WO2001031044A1 (en) * 1999-10-26 2001-05-03 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Gonadotrophins in plants
CN1549861A (zh) * 2001-01-19 2004-11-24 �Ϻ���ͨ��ѧ 利用植物细胞分泌性生产具有人型糖链的糖蛋白的方法
CN1665934A (zh) * 2002-03-19 2005-09-07 国际植物研究所 GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达
CN1756844A (zh) * 2002-03-19 2006-04-05 国际植物研究所 在植物中优化聚糖生成
CN1761746A (zh) * 2003-01-22 2006-04-19 格黎卡特生物技术股份公司 融合构建体及其用来生产Fc受体结合亲和性和效应子功能提高的抗体的用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAZUYA OKADA ET AL.: ""Expression and integration of genes introduced into highly synchronized plant protoplasts"", 《MOL GEN GENET》 *
沈爱国等: ""β-1,4-半乳糖基转移酶的研究进展"", 《交通医学》 *
王洋等: ""植物表达重组蛋白的N-糖基化研究进展"", 《中国农学通报》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111328347A (zh) * 2017-09-11 2020-06-23 R.J.雷诺兹烟草公司 通过与p21共表达来增加植物中感兴趣基因的表达的方法和组合物

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NZ598417A (en) 2013-06-28
RU2010101024A (ru) 2011-07-20
AU2008261527A1 (en) 2008-12-18
RU2013137208A (ru) 2015-02-20
WO2008151440A1 (en) 2008-12-18
EP2155880A4 (en) 2010-08-04
TN2009000512A1 (en) 2011-03-31
EG26600A (en) 2014-03-23
KR101385050B1 (ko) 2014-05-13
CA2795379A1 (en) 2008-12-18
JP5783720B2 (ja) 2015-09-24
CA2700180C (en) 2013-01-29
SI2155880T1 (sl) 2017-03-31
PL2155880T3 (pl) 2017-06-30
NZ581944A (en) 2012-03-30
BRPI0812538A2 (pt) 2014-09-30
ES2624776T3 (es) 2017-07-17
WO2008151440A8 (en) 2010-03-04
KR20130075787A (ko) 2013-07-05
MA31516B1 (fr) 2010-07-01
MX2009013665A (es) 2010-06-02
US20110008837A1 (en) 2011-01-13
AU2008261527B8 (en) 2014-04-24
SG185249A1 (en) 2012-11-29
PT2155880T (pt) 2016-11-18
AU2008261527A8 (en) 2010-01-21
BRPI0812538B1 (pt) 2021-03-16
AU2008261527B2 (en) 2014-04-10
IL202568A0 (en) 2011-08-01
DK2155880T3 (en) 2016-12-05
KR20100037602A (ko) 2010-04-09
AU2008261527C1 (en) 2014-09-04
JP2010531136A (ja) 2010-09-24
EP2155880B1 (en) 2016-08-10
IL202568A (en) 2015-02-26
EP2155880A1 (en) 2010-02-24
ZA201000207B (en) 2013-09-25
RU2499053C2 (ru) 2013-11-20
WO2008151440A4 (en) 2009-02-26
CA2700180A1 (en) 2008-12-18
HUE031698T2 (en) 2017-07-28
CN101918559A (zh) 2010-12-15
CN103382487A (zh) 2013-11-06

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