KR101340815B1 - 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제 - Google Patents

에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제 Download PDF

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Publication number
KR101340815B1
KR101340815B1 KR1020117005777A KR20117005777A KR101340815B1 KR 101340815 B1 KR101340815 B1 KR 101340815B1 KR 1020117005777 A KR1020117005777 A KR 1020117005777A KR 20117005777 A KR20117005777 A KR 20117005777A KR 101340815 B1 KR101340815 B1 KR 101340815B1
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South Korea
Prior art keywords
escitalopram
base
tablets
salts
mixture
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KR1020117005777A
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Korean (ko)
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KR20110033310A (ko
Inventor
로버트 댄서
한스 페테르센
올레 닐센
마이클 해롤드 락
헬레 엘리아센
켄 리리에그렌
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하. 룬트벡 아크티에 셀스카브
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020117005777A 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제 Active KR101340815B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200500912 2005-06-22
DKPA200500912 2005-06-22
PCT/DK2006/000366 WO2006136169A2 (en) 2005-06-22 2006-06-22 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020077028918A Division KR20080018191A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를함유한 구강내분산성 정제

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020127014205A Division KR20120064140A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020117015711A Division KR20110084341A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제

Publications (2)

Publication Number Publication Date
KR20110033310A KR20110033310A (ko) 2011-03-30
KR101340815B1 true KR101340815B1 (ko) 2013-12-11

Family

ID=37546630

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020117005777A Active KR101340815B1 (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020077028918A Ceased KR20080018191A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를함유한 구강내분산성 정제
KR1020127014205A Ceased KR20120064140A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020117015711A Ceased KR20110084341A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020107026804A Ceased KR20100133023A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020077028918A Ceased KR20080018191A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를함유한 구강내분산성 정제
KR1020127014205A Ceased KR20120064140A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020117015711A Ceased KR20110084341A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020107026804A Ceased KR20100133023A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제

Country Status (39)

Country Link
EP (3) EP1896439B2 (https=)
JP (5) JP4906852B2 (https=)
KR (5) KR101340815B1 (https=)
CN (2) CN101189220A (https=)
AR (2) AR055062A1 (https=)
AT (3) AT10983U1 (https=)
AU (2) AU2006261452B2 (https=)
BG (1) BG66086B1 (https=)
BR (1) BRPI0612295A2 (https=)
CA (2) CA2646780A1 (https=)
CY (1) CY1112392T1 (https=)
CZ (3) CZ300686B6 (https=)
DE (2) DE602006019961D1 (https=)
DK (3) DK1896439T4 (https=)
EA (2) EA201001108A1 (https=)
EE (1) EE00773U1 (https=)
ES (2) ES2319073B1 (https=)
FI (2) FI20077133L (https=)
GB (2) GB2442160B (https=)
HR (1) HRP20110093T4 (https=)
HU (1) HUP0800135A3 (https=)
IL (1) IL187454A0 (https=)
IS (1) IS8705A (https=)
LT (1) LT5550B (https=)
LV (1) LV13677B (https=)
MX (1) MX2007015328A (https=)
MY (2) MY143239A (https=)
NO (2) NO20080359L (https=)
PL (2) PL384185A1 (https=)
PT (1) PT1896439E (https=)
RS (1) RS51575B2 (https=)
SG (1) SG169358A1 (https=)
SI (1) SI1896439T2 (https=)
SK (1) SK500402007A3 (https=)
TR (2) TR200708792T1 (https=)
TW (2) TWI358407B (https=)
UA (1) UA86536C2 (https=)
WO (1) WO2006136169A2 (https=)
ZA (2) ZA200711066B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200119021A (ko) 2019-04-09 2020-10-19 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법

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EP2134325A2 (en) * 2007-03-01 2009-12-23 Aurobindo Pharma Limited Stable solid dosage forms of an antidepressant
ES2569984T3 (es) 2010-07-23 2016-05-13 H. Lundbeck A/S Procedimiento para la purificación de sales farmacéuticamente aceptables de escitalopram
CN103360353A (zh) * 2013-08-07 2013-10-23 中国药科大学 草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN110711198B (zh) * 2018-07-12 2022-03-15 山东大学 D-甘露糖在制备抗抑郁药物中的应用
US20240100012A1 (en) * 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200119021A (ko) 2019-04-09 2020-10-19 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법

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CZ2007898A3 (cs) 2008-01-23
BRPI0612295A2 (pt) 2011-01-04
DK200900284A (da) 2009-02-27
AT11883U1 (de) 2011-06-15
GB2448834B (en) 2010-01-20
CZ299906B6 (cs) 2008-12-29
SG169358A1 (en) 2011-03-30
TWI358407B (en) 2012-02-21
MY143252A (en) 2011-04-15
KR20110084341A (ko) 2011-07-21
LT2008005A (en) 2008-10-27
BG110024A (bg) 2008-05-30
IS8705A (is) 2008-01-14
RS51575B (sr) 2011-08-31
UA86536C2 (ru) 2009-04-27
DK1896439T4 (en) 2015-01-12
IL187454A0 (en) 2008-02-09
CA2646780A1 (en) 2006-12-28
KR20080018191A (ko) 2008-02-27
SK500402007A3 (sk) 2008-05-06
GB2442160B (en) 2010-01-20
EP1896439A2 (en) 2008-03-12
AU2006261452B2 (en) 2010-02-04
CZ301286B6 (cs) 2009-12-30
TWI347942B (en) 2011-09-01
BG66086B1 (bg) 2011-03-31
GB0724557D0 (en) 2008-01-23
GB2448834A (en) 2008-10-29
EA019239B1 (ru) 2014-02-28
TW201130808A (en) 2011-09-16
TR200708792T1 (tr) 2008-05-21
AU2010200844A1 (en) 2010-04-01
EE00773U1 (et) 2008-10-15
HRP20110093T1 (hr) 2011-03-31
ES2319073A1 (es) 2009-05-01
PT1896439E (pt) 2011-02-15
ATE497500T1 (de) 2011-02-15
DE112006001619T5 (de) 2008-06-12
AT10983U1 (de) 2010-02-15
CN101189220A (zh) 2008-05-28
FI20077133A7 (fi) 2007-12-20
DE602006019961D1 (de) 2011-03-17
GB2442160A (en) 2008-03-26
JP5731957B2 (ja) 2015-06-10
GB0811164D0 (en) 2008-07-23
PL1896439T5 (pl) 2016-01-29
EA201001108A1 (ru) 2011-02-28
EP2325177A1 (en) 2011-05-25
JP2012072168A (ja) 2012-04-12
ZA200901698B (en) 2010-04-28
FI20077133L (fi) 2007-12-20
NO20101777L (no) 2008-01-18
ZA200711066B (en) 2009-07-29
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LV13677B (en) 2008-05-20
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JP4415056B2 (ja) 2010-02-17
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