DE602006019961D1 - Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten - Google Patents

Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten

Info

Publication number
DE602006019961D1
DE602006019961D1 DE602006019961T DE602006019961T DE602006019961D1 DE 602006019961 D1 DE602006019961 D1 DE 602006019961D1 DE 602006019961 T DE602006019961 T DE 602006019961T DE 602006019961 T DE602006019961 T DE 602006019961T DE 602006019961 D1 DE602006019961 D1 DE 602006019961D1
Authority
DE
Germany
Prior art keywords
orodisperrobable
escitaloprambase
escitalopram
tablets containing
crystalline base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006019961T
Other languages
German (de)
English (en)
Inventor
Robert Dancer
Hans Petersen
Ole Nielsen
Michael Harold Rock
Helle Eliasen
Ken Liljegren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006019961(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE602006019961D1 publication Critical patent/DE602006019961D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602006019961T 2005-06-22 2006-06-22 Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten Active DE602006019961D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500912 2005-06-22
PCT/DK2006/000366 WO2006136169A2 (en) 2005-06-22 2006-06-22 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Publications (1)

Publication Number Publication Date
DE602006019961D1 true DE602006019961D1 (de) 2011-03-17

Family

ID=37546630

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602006019961T Active DE602006019961D1 (de) 2005-06-22 2006-06-22 Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten
DE112006001619T Withdrawn DE112006001619T5 (de) 2005-06-22 2006-06-22 Kristalline Base von Escitalopram und orodispersible Tabletten, die Escitalopram-Base umfassen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE112006001619T Withdrawn DE112006001619T5 (de) 2005-06-22 2006-06-22 Kristalline Base von Escitalopram und orodispersible Tabletten, die Escitalopram-Base umfassen

Country Status (39)

Country Link
EP (3) EP1896439B2 (https=)
JP (5) JP4906852B2 (https=)
KR (5) KR20110084341A (https=)
CN (2) CN101189220A (https=)
AR (2) AR055062A1 (https=)
AT (3) AT10983U1 (https=)
AU (2) AU2006261452B2 (https=)
BG (1) BG66086B1 (https=)
BR (1) BRPI0612295A2 (https=)
CA (2) CA2612827C (https=)
CY (1) CY1112392T1 (https=)
CZ (3) CZ299906B6 (https=)
DE (2) DE602006019961D1 (https=)
DK (3) DK1896439T4 (https=)
EA (2) EA201001108A1 (https=)
EE (1) EE00773U1 (https=)
ES (2) ES2319073B1 (https=)
FI (2) FI20080548A7 (https=)
GB (2) GB2442160B (https=)
HR (1) HRP20110093T4 (https=)
HU (1) HUP0800135A3 (https=)
IL (1) IL187454A0 (https=)
IS (1) IS8705A (https=)
LT (1) LT5550B (https=)
LV (1) LV13677B (https=)
MX (1) MX2007015328A (https=)
MY (2) MY143239A (https=)
NO (2) NO20080359L (https=)
PL (2) PL1896439T5 (https=)
PT (1) PT1896439E (https=)
RS (1) RS51575B2 (https=)
SG (1) SG169358A1 (https=)
SI (1) SI1896439T2 (https=)
SK (1) SK500402007A3 (https=)
TR (2) TR201000625T1 (https=)
TW (2) TWI347942B (https=)
UA (1) UA86536C2 (https=)
WO (1) WO2006136169A2 (https=)
ZA (2) ZA200711066B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
WO2008104880A2 (en) * 2007-03-01 2008-09-04 Aurobindo Pharma Limited Stable solid dosage forms of an antidepressant
EP2595979B1 (en) 2010-07-23 2016-04-06 H. Lundbeck A/S Process for the purification of pharmaceutically acceptable salts of escitalopram
CN103360353A (zh) * 2013-08-07 2013-10-23 中国药科大学 草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN110711198B (zh) * 2018-07-12 2022-03-15 山东大学 D-甘露糖在制备抗抑郁药物中的应用
KR102331187B1 (ko) 2019-04-09 2021-11-26 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법
US20240100012A1 (en) * 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH05222041A (ja) * 1992-02-13 1993-08-31 Mitsubishi Gas Chem Co Inc アデニン誘導体の精製法
WO1995020377A1 (en) * 1994-01-27 1995-08-03 The Board Of Regents Of The University Of Oklahoma Rapidly dissolving oral dosage form
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
EP0993524B1 (en) 1997-06-30 2002-11-20 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
ES2148120T3 (es) 1997-07-08 2002-01-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
WO2002030400A1 (fr) * 2000-10-06 2002-04-18 Takeda Chemical Industries, Ltd. Preparations solides
KR20030042006A (ko) * 2000-10-16 2003-05-27 다이이찌 세이야꾸 가부시기가이샤 구강내 속붕괴성 의약 조성물 및 그의 제조방법
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
WO2001045483A2 (en) * 2000-12-22 2001-06-28 H. Lundbeck A/S Method for the preparation of pure citalopram
JP2003519121A (ja) * 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
WO2002087566A1 (en) * 2001-05-01 2002-11-07 H. Lundbeck A/S The use of enantiomeric pure escitalopram
US6872405B2 (en) * 2001-05-10 2005-03-29 Yamanouchi Pharmaceutical Co., Ltd. Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
GB0113842D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IL159326A0 (en) * 2001-07-31 2004-06-01 Lundbeck & Co As H Crystalline composition containing escitalopram
IS7239A (is) 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1517676A1 (en) * 2002-05-03 2005-03-30 Skyepharma Canada Inc. Oral dosage forms comprising fenofibrate
AU2003287919B2 (en) 2002-12-23 2009-11-12 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
CN1510024A (zh) * 2002-12-24 2004-07-07 北京德众万全药物技术开发有限公司 可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
JP4739217B2 (ja) * 2003-05-07 2011-08-03 サムヤン コーポレイション 速く溶ける錠剤を製造するための高可塑性顆粒
US8647668B2 (en) * 2003-10-15 2014-02-11 Fuji Chemical Industry Co., Ltd. Tablet quickly disintegrating in oral cavity
WO2005049596A1 (en) * 2003-11-20 2005-06-02 Natco Pharma Limited A process for the preparation of high purity escitalopram
HU227491B1 (en) * 2003-11-25 2011-07-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Tablet containing citalopram hydrogen bromide
WO2005084643A1 (en) * 2004-03-05 2005-09-15 H. Lundbeck A/S Crystalline composition containing escitalopram oxalate
EP1877394A1 (en) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Process for the preparation of escitalopram or its acid addition salts

Also Published As

Publication number Publication date
IL187454A0 (en) 2008-02-09
SG169358A1 (en) 2011-03-30
SK500402007A3 (sk) 2008-05-06
ZA200901698B (en) 2010-04-28
CA2612827C (en) 2010-11-30
GB2448834B (en) 2010-01-20
TR200708792T1 (tr) 2008-05-21
LT2008005A (en) 2008-10-27
FI20077133L (fi) 2007-12-20
AR079750A2 (es) 2012-02-15
TR201000625T1 (tr) 2010-03-22
AT11883U1 (de) 2011-06-15
JP4415056B2 (ja) 2010-02-17
NO20080359L (no) 2008-01-18
DK1896439T4 (en) 2015-01-12
GB2442160A (en) 2008-03-26
AT10983U1 (de) 2010-02-15
CZ2007898A3 (cs) 2008-01-23
KR20100133023A (ko) 2010-12-20
RS51575B2 (sr) 2018-02-28
IS8705A (is) 2008-01-14
FI20080548L (fi) 2008-10-07
GB0811164D0 (en) 2008-07-23
EP2385044A1 (en) 2011-11-09
UA86536C2 (ru) 2009-04-27
EP1896439B2 (en) 2014-10-15
KR101340815B1 (ko) 2013-12-11
WO2006136169A2 (en) 2006-12-28
EP1896439B1 (en) 2011-02-02
BRPI0612295A2 (pt) 2011-01-04
ES2319073B1 (es) 2010-02-26
PL384185A1 (pl) 2008-06-23
MY143239A (en) 2011-04-15
ATE497500T1 (de) 2011-02-15
GB0724557D0 (en) 2008-01-23
JP4906852B2 (ja) 2012-03-28
JP2009046506A (ja) 2009-03-05
EP2325177A1 (en) 2011-05-25
JP2009179635A (ja) 2009-08-13
CA2612827A1 (en) 2006-12-28
TWI358407B (en) 2012-02-21
EA201001108A1 (ru) 2011-02-28
CZ300686B6 (cs) 2009-07-15
JP2008546724A (ja) 2008-12-25
ZA200711066B (en) 2009-07-29
HUP0800135A2 (en) 2008-06-30
EE00773U1 (et) 2008-10-15
SI1896439T2 (sl) 2014-12-31
GB2448834A (en) 2008-10-29
TWI347942B (en) 2011-09-01
AR055062A1 (es) 2007-08-01
DE112006001619T5 (de) 2008-06-12
HRP20110093T4 (hr) 2015-02-27
JP2012072168A (ja) 2012-04-12
AU2006261452A1 (en) 2006-12-28
DK200900284A (da) 2009-02-27
ES2319073A1 (es) 2009-05-01
FI20080548A7 (fi) 2008-10-07
HUP0800135A3 (en) 2009-01-28
KR20110084341A (ko) 2011-07-21
PL1896439T5 (pl) 2016-01-29
KR20110033310A (ko) 2011-03-30
TW200740785A (en) 2007-11-01
LT5550B (lt) 2009-03-25
EA019239B1 (ru) 2014-02-28
MY143252A (en) 2011-04-15
ES2356838T5 (es) 2015-01-26
GB2442160B (en) 2010-01-20
AU2010200844A1 (en) 2010-04-01
RS51575B (sr) 2011-08-31
DK1896439T3 (da) 2011-02-28
KR20120064140A (ko) 2012-06-18
TW201130808A (en) 2011-09-16
PT1896439E (pt) 2011-02-15
CN101928269A (zh) 2010-12-29
ES2356838T3 (es) 2011-04-13
SI1896439T1 (sl) 2011-03-31
KR20080018191A (ko) 2008-02-27
CY1112392T1 (el) 2015-12-09
HRP20110093T1 (hr) 2011-03-31
EP1896439A2 (en) 2008-03-12
MX2007015328A (es) 2008-02-15
CA2646780A1 (en) 2006-12-28
PL1896439T3 (pl) 2011-04-29
LV13677B (en) 2008-05-20
EA200800102A1 (ru) 2008-04-28
NO20101777L (no) 2008-01-18
BG66086B1 (bg) 2011-03-31
WO2006136169A3 (en) 2007-10-18
CZ299906B6 (cs) 2008-12-29
CZ301286B6 (cs) 2009-12-30
JP5731957B2 (ja) 2015-06-10
AU2006261452B2 (en) 2010-02-04
BG110024A (bg) 2008-05-30
CN101189220A (zh) 2008-05-28
DK200800075A (da) 2008-03-15
FI20077133A7 (fi) 2007-12-20
JP2009179634A (ja) 2009-08-13

Similar Documents

Publication Publication Date Title
DE602005004988D1 (de) Reversibele thermochromische Zusammensetzung und Mikrokapseln, die diese enthalten
LU92426I2 (fr) Canagliflozine
NO20040933L (no) Nye gamma-sekretaseinhibitorer.
EP1594979A4 (en) SURFACES WITH MODIFIED NANOCYLINDERS
NO20044588L (no) Nye forbindelser
NO20054005D0 (no) Nye arylpiperazinylforbindelser
NO20044432L (no) Nye forbindelser
EP1627259A4 (en) COMPOSITIONS ADAPTED FOR REMOVING PHOTORESINE, PHOTORESIN DERIVATIVE PRODUCTS AND ETCH RESIDUES, AND USES THEREOF
HUS1500006I1 (hu) Benzotiazol-származék vegyületek, kompozíciók és alkalmazások
DE602004013405D1 (de) Polymorphe formen von valsartan
NO20052683D0 (no) Nye pyridopyrimidinonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
DE602004031170D1 (de) Druckmaschine
DK1704148T3 (da) Nye kondenserede pyrrolocarbazoler
DE602004009120D1 (de) Stanzpresse
IL187454A0 (en) Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
NO20043595L (no) Nye kortikosteroider
ATE405943T1 (de) Quecksilberfreisetzende zusammensetzungen und herstellungsverfahren dafür
DE602004023623D1 (de) Chirale verbindungen und zusammensetzungen, die diese enthalten
DE60334012D1 (de) Valerolactonverbindungen und parf mzusammensetzung
DE602004014804D1 (de) Haltenden tabletten
DE602004009733D1 (de) Dynamisches Ratenteilungsverfahren
NO20055657D0 (no) Nye bioisostaererav aktinonin
DE60336431D1 (de) Aterial
DE602004013897D1 (de) Stanznocken
ATE377639T1 (de) Neue klebemittel, die diacetale enthalten