KR101321619B1 - 스틸벤 유도체, 및 아밀로이드 플라크에 결합 및영상화하기 위한 그의 용도 - Google Patents

스틸벤 유도체, 및 아밀로이드 플라크에 결합 및영상화하기 위한 그의 용도 Download PDF

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KR101321619B1
KR101321619B1 KR1020077016290A KR20077016290A KR101321619B1 KR 101321619 B1 KR101321619 B1 KR 101321619B1 KR 1020077016290 A KR1020077016290 A KR 1020077016290A KR 20077016290 A KR20077016290 A KR 20077016290A KR 101321619 B1 KR101321619 B1 KR 101321619B1
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ethoxy
phenyl
compound
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vinyl
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KR20070093427A (ko
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행크 에프. 쿵
메이-핑 쿵
치-핑 추앙
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더 트러스티스 오브 더 유니버시티 오브 펜실바니아
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077016290A 2004-12-17 2005-12-19 스틸벤 유도체, 및 아밀로이드 플라크에 결합 및영상화하기 위한 그의 용도 Expired - Lifetime KR101321619B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US60/636,696 2004-12-17
US68639505P 2005-06-02 2005-06-02
US60/686,395 2005-06-02
PCT/US2005/045682 WO2006066104A2 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (2)

Publication Number Publication Date
KR20070093427A KR20070093427A (ko) 2007-09-18
KR101321619B1 true KR101321619B1 (ko) 2013-10-30

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KR1020077016290A Expired - Lifetime KR101321619B1 (ko) 2004-12-17 2005-12-19 스틸벤 유도체, 및 아밀로이드 플라크에 결합 및영상화하기 위한 그의 용도

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US (2) US7807135B2 (https=)
EP (3) EP2213652B1 (https=)
JP (1) JP5128956B2 (https=)
KR (1) KR101321619B1 (https=)
AU (1) AU2005316421B2 (https=)
BE (1) BE2015C015I2 (https=)
BR (1) BRPI0516408B8 (https=)
CA (1) CA2591534C (https=)
DK (1) DK2213652T3 (https=)
EA (1) EA012334B1 (https=)
ES (1) ES2526655T3 (https=)
FR (1) FR15C0012I2 (https=)
HU (1) HUS1500014I1 (https=)
IL (2) IL183946A (https=)
LT (1) LTC2213652I2 (https=)
LU (1) LU92647I2 (https=)
MX (1) MX2007007380A (https=)
NL (1) NL300719I2 (https=)
NO (1) NO339195B1 (https=)
NZ (1) NZ555942A (https=)
PL (1) PL2213652T3 (https=)
PT (1) PT2213652E (https=)
SG (1) SG194363A1 (https=)
SI (1) SI2213652T1 (https=)
WO (1) WO2006066104A2 (https=)

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EP2213652B1 (en) * 2004-12-17 2014-10-22 The Trustees of The University of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
JP2008546804A (ja) * 2005-06-24 2008-12-25 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 造影剤として用いるためのリガンドの放射性標識ペグ化
PL1999109T3 (pl) * 2006-03-30 2012-05-31 Univ Pennsylvania Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
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US8779002B2 (en) * 2007-10-15 2014-07-15 Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
EP2247558B2 (en) * 2008-02-14 2024-07-03 Eli Lilly and Company Novel imaging agents for detecting neurological dysfunction
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
EP2247944A1 (en) * 2008-02-27 2010-11-10 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
JP2012508889A (ja) * 2008-11-13 2012-04-12 アビッド レディオファーマシューティカルズ、インク． 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法
WO2010072342A2 (en) 2008-12-22 2010-07-01 Bayer Schering Pharma Aktiengesellschaft A method for the synthesis of a radionuclide-labeled compound
PT2381967T (pt) * 2008-12-31 2017-02-24 Avid Radiopharmaceuticals Inc Síntese de estirilpiridinas radiomarcadas com 18f a partir de precursores tosilato e as suas composições farmacêuticas estáveis
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
CA2767475A1 (en) 2009-07-10 2011-01-13 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
MX336896B (es) * 2009-12-23 2016-02-05 Piramal Imaging Sa Formulaciones adecuadas para la generacion de imagenes pet con agentes pet hidrofobicos.
CA2801525A1 (en) 2010-06-04 2011-12-08 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
WO2011151282A1 (en) * 2010-06-04 2011-12-08 Bayer Pharma Aktiengesellschaft Method for production of f-18 labeled amyloid beta ligand
SG185782A1 (en) 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
EP2699157B1 (en) * 2011-04-21 2018-03-14 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
BR112013032610B1 (pt) * 2011-06-21 2022-05-31 Life Molecular Imaging Sa Formulações de estilbeno fluorado adequadas para imagiologia pet, e seus métodos de preparação, obtenção e filtração estéril
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
EP2768790A1 (en) 2011-10-19 2014-08-27 Piramal Imaging SA IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS
PT2836241T (pt) 2012-04-10 2019-05-30 Lantheus Medical Imaging Inc Métodos de síntese de radiofármacos
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) * 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
JP6765518B2 (ja) 2016-09-29 2020-10-07 コリア アトミック エナジー リサーチ インスティテュートＫｏｒｅａ Ａｔｏｍｉｃ Ｅｎｅｒｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ クルクミン誘導体、その製造方法、及びそれを含むベータ−アミロイドプラーク検出用光音響イメージング剤
TWI752098B (zh) 2016-10-10 2022-01-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物

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EP2213652B1 (en) * 2004-12-17 2014-10-22 The Trustees of The University of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
JP2008546804A (ja) * 2005-06-24 2008-12-25 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 造影剤として用いるためのリガンドの放射性標識ペグ化

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EP1841465A2 (en) 2007-10-10
NL300719I1 (https=) 2015-12-29
SI2213652T1 (sl) 2015-03-31
EP1838298A4 (en) 2009-03-04
IL183946A0 (en) 2007-10-31
EA200701299A1 (ru) 2007-12-28
BRPI0516408A (pt) 2008-09-02
WO2006066104A2 (en) 2006-06-22
BRPI0516408B8 (pt) 2021-05-25
CA2591534C (en) 2013-08-06
FR15C0012I1 (https=) 2015-03-20
MX2007007380A (es) 2007-10-11
KR20070093427A (ko) 2007-09-18
HUS1500014I1 (hu) 2016-11-28
US7807135B2 (en) 2010-10-05
WO2006066104A3 (en) 2006-08-03
FR15C0012I2 (fr) 2015-11-20
LTC2213652I2 (lt) 2016-12-27
EP1838298A2 (en) 2007-10-03
JP5128956B2 (ja) 2013-01-23
IL206091A (en) 2013-08-29
NZ555942A (en) 2011-01-28
US20100266500A1 (en) 2010-10-21
CA2591534A1 (en) 2006-06-22
EP2213652A1 (en) 2010-08-04
BE2015C015I2 (https=) 2025-04-29
NO339195B1 (no) 2016-11-14
IL183946A (en) 2011-08-31
US8465726B2 (en) 2013-06-18
NO20073650L (no) 2007-09-14
EA012334B1 (ru) 2009-08-28
NL300719I2 (https=) 2015-12-29
PT2213652E (pt) 2015-01-02
AU2005316421A1 (en) 2006-06-22
JP2008524243A (ja) 2008-07-10
LU92647I2 (fr) 2015-11-03
ES2526655T3 (es) 2015-01-14
AU2005316421B2 (en) 2012-04-05
PL2213652T3 (pl) 2015-04-30
EP2213652B1 (en) 2014-10-22
BRPI0516408B1 (pt) 2021-03-23
US20060269473A1 (en) 2006-11-30
SG194363A1 (en) 2013-11-29
EP1841465A4 (en) 2009-04-01
DK2213652T3 (en) 2015-01-26

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