KR101250824B1 - 바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는크로마닐우레아 화합물 및 이의 용도 - Google Patents

바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는크로마닐우레아 화합물 및 이의 용도 Download PDF

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Publication number
KR101250824B1
KR101250824B1 KR1020077014371A KR20077014371A KR101250824B1 KR 101250824 B1 KR101250824 B1 KR 101250824B1 KR 1020077014371 A KR1020077014371 A KR 1020077014371A KR 20077014371 A KR20077014371 A KR 20077014371A KR 101250824 B1 KR101250824 B1 KR 101250824B1
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South Korea
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alkyl
indazol
dihydro
methyl
chromen
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Expired - Fee Related
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KR1020077014371A
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English (en)
Korean (ko)
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KR20070086607A (ko
Inventor
아서 알. 곰챤
에롤 케이. 베이버트
2세 로버트 쥐. 슈미트
치-훙 리
에스. 브라이언 브라운
케이. 타미 진커슨
알. 존 쾨닉
에프. 제롬 대넌
스티브 랏셔
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아보트 러보러터리즈
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Publication of KR101250824B1 publication Critical patent/KR101250824B1/ko
Assigned to 애브비 인코포레이티드 reassignment 애브비 인코포레이티드 권리의 전부이전등록 Assignors: 아보트 러보러터리즈
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020077014371A 2004-11-24 2005-11-22 바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는크로마닐우레아 화합물 및 이의 용도 Expired - Fee Related KR101250824B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63063604P 2004-11-24 2004-11-24
US60/630,636 2004-11-24
PCT/US2005/042545 WO2006065484A2 (en) 2004-11-24 2005-11-22 Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020127028557A Division KR20120137420A (ko) 2004-11-24 2005-11-22 바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는 크로마닐우레아 화합물 및 이의 용도

Publications (2)

Publication Number Publication Date
KR20070086607A KR20070086607A (ko) 2007-08-27
KR101250824B1 true KR101250824B1 (ko) 2013-04-05

Family

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Family Applications (2)

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KR1020077014371A Expired - Fee Related KR101250824B1 (ko) 2004-11-24 2005-11-22 바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는크로마닐우레아 화합물 및 이의 용도
KR1020127028557A Withdrawn KR20120137420A (ko) 2004-11-24 2005-11-22 바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는 크로마닐우레아 화합물 및 이의 용도

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KR1020127028557A Withdrawn KR20120137420A (ko) 2004-11-24 2005-11-22 바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는 크로마닐우레아 화합물 및 이의 용도

Country Status (13)

Country Link
US (2) US7812019B2 (cg-RX-API-DMAC7.html)
EP (2) EP1844038A2 (cg-RX-API-DMAC7.html)
JP (2) JP4932730B2 (cg-RX-API-DMAC7.html)
KR (2) KR101250824B1 (cg-RX-API-DMAC7.html)
CN (2) CN102161653A (cg-RX-API-DMAC7.html)
AU (1) AU2005316972B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0518581A2 (cg-RX-API-DMAC7.html)
CA (1) CA2588909A1 (cg-RX-API-DMAC7.html)
IL (1) IL183321A0 (cg-RX-API-DMAC7.html)
MX (1) MX2007006205A (cg-RX-API-DMAC7.html)
NZ (1) NZ555318A (cg-RX-API-DMAC7.html)
TW (1) TW200633712A (cg-RX-API-DMAC7.html)
WO (1) WO2006065484A2 (cg-RX-API-DMAC7.html)

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US8145180B2 (en) * 2004-05-21 2012-03-27 Rosemount Inc. Power generation for process devices
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US20060160850A1 (en) * 2005-01-18 2006-07-20 Chongqing Sun Bicyclic heterocycles as cannabinoid receptor modulators
JP2008538576A (ja) * 2005-04-22 2008-10-30 ワイス クロマンおよびクロメン誘導体およびその使用
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WO2009095726A1 (en) * 2008-01-29 2009-08-06 Glenmark Pharmaceuticals, S.A. Acrylamide derivatives as vanilloid receptor 1 modulators
JP5305704B2 (ja) * 2008-03-24 2013-10-02 富士フイルム株式会社 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版
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US8609692B2 (en) * 2008-10-17 2013-12-17 Abbvie Inc. TRPV1 antagonists
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
CN101654435B (zh) * 2009-06-09 2014-01-29 沈阳药科大学 N-苯甲基喹啉羧酸类化合物、组合物及其制备方法
US20100318007A1 (en) * 2009-06-10 2010-12-16 O'brien Donald J Electromechanical tactile stimulation devices and methods
US9674976B2 (en) 2009-06-16 2017-06-06 Rosemount Inc. Wireless process communication adapter with improved encapsulation
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CN103739547B (zh) * 2014-01-03 2015-09-02 沈阳药科大学 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法
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CN109574972A (zh) * 2018-07-13 2019-04-05 郑州大学 一种3-烷基取代-4-色满酮类化合物及其制备方法
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WO2003097586A1 (en) * 2002-05-17 2003-11-27 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid vr1 receptor

Also Published As

Publication number Publication date
WO2006065484A3 (en) 2009-02-19
AU2005316972A1 (en) 2006-06-22
US20060128689A1 (en) 2006-06-15
JP2012111766A (ja) 2012-06-14
WO2006065484A2 (en) 2006-06-22
JP4932730B2 (ja) 2012-05-16
CN101443327A (zh) 2009-05-27
BRPI0518581A2 (pt) 2008-11-25
EP1844038A2 (en) 2007-10-17
NZ555318A (en) 2011-01-28
US20110152250A1 (en) 2011-06-23
JP2008532925A (ja) 2008-08-21
KR20070086607A (ko) 2007-08-27
US7812019B2 (en) 2010-10-12
KR20120137420A (ko) 2012-12-20
EP2527339A1 (en) 2012-11-28
AU2005316972B2 (en) 2011-11-10
MX2007006205A (es) 2009-02-13
IL183321A0 (en) 2008-04-13
US8440691B2 (en) 2013-05-14
CA2588909A1 (en) 2006-06-22
CN102161653A (zh) 2011-08-24
TW200633712A (en) 2006-10-01

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