KR101215023B1 - 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성 방법 및 상응하는 대사 생성물 - Google Patents

고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성 방법 및 상응하는 대사 생성물 Download PDF

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KR101215023B1
KR101215023B1 KR1020107021724A KR20107021724A KR101215023B1 KR 101215023 B1 KR101215023 B1 KR 101215023B1 KR 1020107021724 A KR1020107021724 A KR 1020107021724A KR 20107021724 A KR20107021724 A KR 20107021724A KR 101215023 B1 KR101215023 B1 KR 101215023B1
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metabolic product
metabolic
liquid
chromatography
isotopically labeled
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KR1020107021724A
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KR20100110400A (ko
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마르틴 프로이덴쉬우스
게오르크 하우블
루돌프 크르스카
귄터 자우넥커
에바 빈더
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에르버 악티엔게젤샤프트
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107021724A 2005-04-05 2006-03-31 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성 방법 및 상응하는 대사 생성물 KR101215023B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0057405A AT501629B1 (de) 2005-04-05 2005-04-05 Herstellung von hochgradig isotopenmarkierten, sekundären, mikrobiellen stoffwechselprodukten sowie stoffwechselprodukte
ATA574/2005 2005-04-05

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KR1020077025065A Division KR101013706B1 (ko) 2005-04-05 2006-03-31 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성방법 및 상응하는 대사 생성물

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KR20100110400A KR20100110400A (ko) 2010-10-12
KR101215023B1 true KR101215023B1 (ko) 2012-12-24

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KR1020107021724A KR101215023B1 (ko) 2005-04-05 2006-03-31 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성 방법 및 상응하는 대사 생성물
KR1020077025065A KR101013706B1 (ko) 2005-04-05 2006-03-31 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성방법 및 상응하는 대사 생성물

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Country Status (20)

Country Link
US (1) US20090068706A1 (de)
EP (1) EP1866423B1 (de)
JP (1) JP5231212B2 (de)
KR (2) KR101215023B1 (de)
CN (1) CN101155924A (de)
AT (2) AT501629B1 (de)
AU (1) AU2006230781B2 (de)
BR (1) BRPI0607784A2 (de)
CA (1) CA2602415C (de)
DK (1) DK1866423T3 (de)
ES (1) ES2381275T3 (de)
IL (1) IL186043A (de)
MX (1) MX2007012315A (de)
PL (1) PL1866423T3 (de)
PT (1) PT1866423E (de)
RU (1) RU2407797C2 (de)
SG (1) SG160414A1 (de)
SI (1) SI1866423T1 (de)
WO (1) WO2006105563A2 (de)
ZA (1) ZA200708207B (de)

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DE102010019869B4 (de) 2010-05-07 2012-04-05 Bruker Daltonik Gmbh Massenspektrometrischer Schnellnachweis von Salmonellen
CN101914586B (zh) * 2010-07-14 2012-05-30 江苏省农业科学院 Don毒素的制备纯化方法
EP2687854A1 (de) 2012-07-19 2014-01-22 Chiron AS Testkit für die quantitative Bestimmung von narkotischen Arzneimitteln
CN103421019B (zh) * 2012-11-02 2015-08-26 华中农业大学 氚标记脱氧镰刀菌烯醇的微量制备方法
EA201201654A1 (ru) * 2012-12-28 2014-06-30 Ооо "Эн.Си.Фарм" Противоопухолевое средство (варианты)
DE102013011509A1 (de) 2013-07-11 2015-01-15 Martin-Luther-Universität Halle-Wittenberg, Körperschaft des öffentlichen Rechts Verfahren zur Biosynthese von spezifisch isotopenmarkierten Sekundermetaboliten
CN103351371B (zh) * 2013-07-23 2015-03-04 江苏省农业科学院 通过麦粒培养基制备纯化zen毒素的方法
EP3266874A1 (de) 2016-07-08 2018-01-10 Universität Wien Fermentative herstellung und isolierung von stabilen isotopmarkierten metaboliten aus mikrobiellen zellwänden und/oder zellmembranen
CN108593753B (zh) * 2016-11-25 2020-06-05 北京毅新博创生物科技有限公司 通过内部标准物质谱检测微生物的内标校正方法
CN108760929A (zh) * 2018-06-13 2018-11-06 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） 一种检测广佛手8种真菌毒素的方法
CN109593676B (zh) * 2018-12-21 2023-04-07 江苏大学 一种用于酸菜发酵液中微生物分离的培养基及其制备方法
CN111849796B (zh) * 2019-04-26 2023-01-13 姚瑞莲 稳定同位素标记的细胞内中间代谢物及其制备方法
CN112979605A (zh) * 2021-03-03 2021-06-18 上海海关动植物与食品检验检疫技术中心 一种稳定同位素标记的玉米赤霉烯酮及其合成方法
CN115290739B (zh) * 2022-08-12 2024-04-26 中国科学技术大学 细菌代谢物分析方法

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IL186043A0 (en) 2008-02-09
KR20070118675A (ko) 2007-12-17
US20090068706A1 (en) 2009-03-12
MX2007012315A (es) 2007-12-11
EP1866423A2 (de) 2007-12-19
ZA200708207B (en) 2008-11-26
PL1866423T3 (pl) 2012-07-31
ES2381275T3 (es) 2012-05-24
EP1866423B1 (de) 2012-01-25
DK1866423T3 (da) 2012-04-16
JP2008534027A (ja) 2008-08-28
BRPI0607784A2 (pt) 2009-06-13
SI1866423T1 (sl) 2012-05-31
CA2602415C (en) 2013-10-01
RU2007140982A (ru) 2009-05-20
KR101013706B1 (ko) 2011-02-10
CA2602415A1 (en) 2006-10-12
JP5231212B2 (ja) 2013-07-10
AU2006230781B2 (en) 2011-04-07
AT501629B1 (de) 2007-10-15
WO2006105563A2 (de) 2006-10-12
PT1866423E (pt) 2012-04-03
IL186043A (en) 2015-04-30
AT501629A1 (de) 2006-10-15
RU2407797C2 (ru) 2010-12-27
ATE542914T1 (de) 2012-02-15
SG160414A1 (en) 2010-04-29
AU2006230781A1 (en) 2006-10-12
CN101155924A (zh) 2008-04-02
KR20100110400A (ko) 2010-10-12
WO2006105563A3 (de) 2006-12-14

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