KR20070118675A - 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성방법 및 상응하는 대사 생성물 - Google Patents
고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성방법 및 상응하는 대사 생성물 Download PDFInfo
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- KR20070118675A KR20070118675A KR1020077025065A KR20077025065A KR20070118675A KR 20070118675 A KR20070118675 A KR 20070118675A KR 1020077025065 A KR1020077025065 A KR 1020077025065A KR 20077025065 A KR20077025065 A KR 20077025065A KR 20070118675 A KR20070118675 A KR 20070118675A
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Abstract
Description
Claims (14)
- 진균 또는 세균을 비활성 담체상에 고정시키고, 탄소 원자, 질소 원자 및/또는 황 원자의 실질적으로 전부가 안정한 동위원소로 대체된 액체 합성 배양 배지를 첨가함으로써 합성을 수행함을 특징으로 하는, 액체 합성 배양 배지에서 진균 또는 세균의 동위원소 표지된 2차 대사 생성물을 생성시키는 방법.
- 제 1항에 있어서, 당 또는 당 알코올, 특히 D-[U-13C6]-글루코오스, 13C-수크로오스, 13C-글리세롤 및/또는 13C-아세테이트가 액체 합성 배양 배지에서 탄소원으로서 사용되고, 15N-아미노산, -니트레이트, -암모늄 화합물 또는 -우레아가 질소원으로서 사용되고, 33S- 또는 34S-설페이트, -설파이드 또는 -아미노산이 황원으로서 사용됨을 특징으로 하는 방법.
- 제 1항 또는 제 2항에 있어서, 액체 합성 배양 배지가 Na+, K+, Ca++, Mg++, Fe+++, Zn++, Cu++, B+++ 뿐만 아니라 CO3--, SO4 --, PO4 ---, NO3 - 이온을 지닌 무기 염 또는 산 및 염기로부터 선택되는 혼합물을 추가로 함유함을 특징으로 하는 방법.
- 제 1항 내지 제 3항 중 어느 한 항에 있어서, 커다란 내부 표면적을 지닌 천연 또는 합성 담체, 특히 실리케이트, 층상 실리케이트, 제올라이트, 벤토나이트, 소성 점토, 규조토, 합성물 등이 상기 비활성 담체로서 사용됨을 특징으로 하는 방법.
- 제 4항에 있어서, 운모 광물 군으로부터의 알루미늄 실리케이트, 예를 들어 제올라이트 또는 층상 실리케이트, 특히 버미큘라이트가 천연 형태 또는 처리된 형태로 상기 비활성 담체로서 사용됨을 특징으로 하는 방법.
- 제 4항에 있어서, 발포 물질, 폴리아미드, 실리콘, 폴리에틸렌, 폴리프로필렌, 폴리테트라플루오로에틸렌, 폴리에스테르 등이 상기 비활성 합성 담체로서 사용됨을 특징으로 하는 방법.
- 제 1항 내지 제 6항 중 어느 한 항에 있어서, 3 내지 45℃, 특히 10 내지 35℃의 온도에서 생성이 이루어짐을 특징으로 하는 방법.
- 제 1항 내지 제 7항 중 어느 한 항에 있어서, 동위원소 표지된 2차 대사 생성물이 추출 및 농축에 의해, 예를 들어 고체/액체-액체/액체 추출, 원심분리, 여과 및 증발과 같은 단계들의 조합에 의해 액체 합성 배양 배지로부터 회수됨을 특징으로 하는 방법.
- 제 8항에 있어서, 크로마토그래피 방법, 특히 컬럼 크로마토그래피, 제조용 박막 크로마토그래피, 이온 크로마토그래피, 친화성 크로마토그래피, 배제 크로마토그래피 및/또는 제조용 고압 액체 크로마토그래피가 정제 방법으로서 사용됨을 특징으로 하는 방법.
- 동물 사료공급 시험에서 대사 연구를 수행하고, 대사 연구를 수행하고, 대사 주기, 분해 경로 및/또는 분해 기간 뿐만 아니라 개재(intercalation)를 해명하는데 있어서 그리고 분석학에서 내부 표준을 생성하기 위한, 제 1항 내지 제 9항 중 어느 한 항에 따른 방법에 의해 생성된 진균 및 세균의 동위원소 표지된 2차 대사 생성물.
- 제 10항에 있어서, 미코톡신, 특히 트리코테센(trichothecene), 예를 들어 니발레놀(nivalenol), 데옥시니발레놀, 3-아세틸-데옥시니발레놀, 15-아세틸-데옥시니발레놀, 푸사레논(fusarenon)-X, T-2 독소, HT-2 독소, DAS, 푸모니신(fumonisin), 예를 들어 푸모니신 B1, B2 또는 B3, 오크라톡신(ochratoxin), 예를 들어 오크라톡신 A, B, C 또는 D, 제아랄레논(zearalenone), 모닐리포르민(moniliformin) 또는 아플라톡신(aflatoxin), 예를 들어 아플라톡신 B1, B2, G1 또는 G2가 대사 생성물로서 사용됨을 특징으로 하는 대사 생성물.
- 제 10항에 있어서, 독소, 예를 들어 내독소 및 외독소, 특히 대장균 종, 살모넬라 종, 클로스트리듐 종, 바실러스 종 또는 스타필로코커스 종의 세균 독소가 상기 대사 생성물로서 사용됨을 특징으로 하는 대사 생성물.
- 제 10항에 있어서, 항생제, 특히 테트라사이클린, 스트렙토마이신 또는 아미노글리코시드와 같은 방선균(actinomycetes)으로부터 형성된 항생제, 박시트라신 또는 폴리믹신과 같은 바실러스 종으로부터 형성된 항생제, 페니실린 또는 그리세오풀빈과 같은 페니실리움(penicillium)으로부터 형성된 항생제, 또는 세팔로스포리움(cephalosporium)으로부터 형성된 세팔로스포린이 상기 대사 생성물로서 사용됨을 특징으로 하는 대사 생성물.
- 95% 이상의 13C, 15N, 또는 33S 또는 34S에 의한 표지화 정도를 지닌, 순수한 물질로서의 제 10항 내지 제 13항 중 어느 한 항에 따른 대사 생성물.
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AT0057405A AT501629B1 (de) | 2005-04-05 | 2005-04-05 | Herstellung von hochgradig isotopenmarkierten, sekundären, mikrobiellen stoffwechselprodukten sowie stoffwechselprodukte |
ATA574/2005 | 2005-04-05 |
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KR1020107021724A Division KR101215023B1 (ko) | 2005-04-05 | 2006-03-31 | 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성 방법 및 상응하는 대사 생성물 |
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KR20070118675A true KR20070118675A (ko) | 2007-12-17 |
KR101013706B1 KR101013706B1 (ko) | 2011-02-10 |
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KR1020107021724A KR101215023B1 (ko) | 2005-04-05 | 2006-03-31 | 고도로 동위원소 표지된 2차 미생물 대사 생성물의 생성 방법 및 상응하는 대사 생성물 |
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US (1) | US20090068706A1 (ko) |
EP (1) | EP1866423B1 (ko) |
JP (1) | JP5231212B2 (ko) |
KR (2) | KR101013706B1 (ko) |
CN (1) | CN101155924A (ko) |
AT (2) | AT501629B1 (ko) |
AU (1) | AU2006230781B2 (ko) |
BR (1) | BRPI0607784A2 (ko) |
CA (1) | CA2602415C (ko) |
DK (1) | DK1866423T3 (ko) |
ES (1) | ES2381275T3 (ko) |
IL (1) | IL186043A (ko) |
MX (1) | MX2007012315A (ko) |
PL (1) | PL1866423T3 (ko) |
PT (1) | PT1866423E (ko) |
RU (1) | RU2407797C2 (ko) |
SG (1) | SG160414A1 (ko) |
SI (1) | SI1866423T1 (ko) |
WO (1) | WO2006105563A2 (ko) |
ZA (1) | ZA200708207B (ko) |
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DE102010019869B4 (de) | 2010-05-07 | 2012-04-05 | Bruker Daltonik Gmbh | Massenspektrometrischer Schnellnachweis von Salmonellen |
CN101914586B (zh) * | 2010-07-14 | 2012-05-30 | 江苏省农业科学院 | Don毒素的制备纯化方法 |
EP2687854A1 (en) * | 2012-07-19 | 2014-01-22 | Chiron AS | Test kit for the quantitative determination of narcotic drugs |
CN103421019B (zh) * | 2012-11-02 | 2015-08-26 | 华中农业大学 | 氚标记脱氧镰刀菌烯醇的微量制备方法 |
EA201201654A1 (ru) * | 2012-12-28 | 2014-06-30 | Ооо "Эн.Си.Фарм" | Противоопухолевое средство (варианты) |
DE102013011509A1 (de) | 2013-07-11 | 2015-01-15 | Martin-Luther-Universität Halle-Wittenberg, Körperschaft des öffentlichen Rechts | Verfahren zur Biosynthese von spezifisch isotopenmarkierten Sekundermetaboliten |
CN103351371B (zh) * | 2013-07-23 | 2015-03-04 | 江苏省农业科学院 | 通过麦粒培养基制备纯化zen毒素的方法 |
EP3266874A1 (en) | 2016-07-08 | 2018-01-10 | Universität Wien | Fermentative production and isolation of stable isotope labeled metabolites from microbial cell walls and/or cell membranes |
CN108593753B (zh) * | 2016-11-25 | 2020-06-05 | 北京毅新博创生物科技有限公司 | 通过内部标准物质谱检测微生物的内标校正方法 |
CN108760929A (zh) * | 2018-06-13 | 2018-11-06 | 广东省药品检验所(广东省药品质量研究所、广东省口岸药品检验所) | 一种检测广佛手8种真菌毒素的方法 |
CN109593676B (zh) * | 2018-12-21 | 2023-04-07 | 江苏大学 | 一种用于酸菜发酵液中微生物分离的培养基及其制备方法 |
CN111849796B (zh) * | 2019-04-26 | 2023-01-13 | 姚瑞莲 | 稳定同位素标记的细胞内中间代谢物及其制备方法 |
CN112979605A (zh) * | 2021-03-03 | 2021-06-18 | 上海海关动植物与食品检验检疫技术中心 | 一种稳定同位素标记的玉米赤霉烯酮及其合成方法 |
CN115290739B (zh) * | 2022-08-12 | 2024-04-26 | 中国科学技术大学 | 细菌代谢物分析方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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IL30380A (en) * | 1967-09-25 | 1972-02-29 | Commercial Solvents Corp | A synthetic fermentation medium and its use in production of 6-(6'-oxo-10'-hydroxy-1'-undecenyl)-2,4-dihydroxy-benzoic acid lactone |
KR900003707B1 (ko) * | 1985-10-25 | 1990-05-30 | 셀진 코오포레이션 | 안정한 동위원소로 표지된 생화학 물질 및 그 제조방법 |
US5314814A (en) * | 1985-11-15 | 1994-05-24 | Gist-Brocades | Preparation of novel immobilized biocatalysts |
CA2083253A1 (en) * | 1991-11-20 | 1993-05-21 | G. Dennis Sprott | Production of metabolites by methanogens |
JPH06319581A (ja) * | 1993-03-15 | 1994-11-22 | Nippon Sanso Kk | 安定同位体標識rnaおよびリボヌクレオチドの製造方法 |
JPH0723794A (ja) * | 1993-07-02 | 1995-01-27 | Nippon Sanso Kk | 細菌同定用培地及び細菌同定方法 |
WO1997018321A1 (en) * | 1995-11-15 | 1997-05-22 | Martek Corporation | Photosynthetic production of stable isotopically labeled recombinant proteins |
EP1101818A4 (en) * | 1998-07-21 | 2003-02-05 | Kansai Chem Eng | METHOD FOR INCREASING THE CATALYTIC ACTIVITY OF CELLS |
DE19839491A1 (de) * | 1998-08-29 | 2000-03-02 | Hermann Heumann | Verfahren zur Markierung von Biopolymeren mit Isotopen |
US6261811B1 (en) * | 1998-12-22 | 2001-07-17 | University Of Georgia Research Foundation, Inc. | Synthesis of natural product metabolites using immobilized fungal spores |
JP4780815B2 (ja) * | 1999-08-26 | 2011-09-28 | 三洋電機株式会社 | エレクトロルミネッセンス表示装置の駆動方法 |
DK1092764T3 (da) * | 1999-10-11 | 2010-04-26 | Dsm Ip Assets Bv | Kontinuerlig fermentering |
FR2820758B1 (fr) * | 2001-02-09 | 2004-05-14 | Univ Pasteur | Procede pour produire des proteines recombinantes, marquees par au moins un isotope |
US7183235B2 (en) * | 2002-06-21 | 2007-02-27 | Ada Technologies, Inc. | High capacity regenerable sorbent for removing arsenic and other toxic ions from drinking water |
EP1644474B1 (en) * | 2003-07-11 | 2012-06-27 | Tatiana A. Egorova-Zachernyuk | Compositions and methods for stable isotope labelling of biological compounds |
US20050049207A1 (en) * | 2003-09-03 | 2005-03-03 | Kaufmann Doug A. | Method of treating and preventing cancer |
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Also Published As
Publication number | Publication date |
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EP1866423B1 (de) | 2012-01-25 |
WO2006105563A2 (de) | 2006-10-12 |
KR101013706B1 (ko) | 2011-02-10 |
ES2381275T3 (es) | 2012-05-24 |
PL1866423T3 (pl) | 2012-07-31 |
CN101155924A (zh) | 2008-04-02 |
PT1866423E (pt) | 2012-04-03 |
CA2602415C (en) | 2013-10-01 |
WO2006105563A3 (de) | 2006-12-14 |
AU2006230781B2 (en) | 2011-04-07 |
KR101215023B1 (ko) | 2012-12-24 |
IL186043A (en) | 2015-04-30 |
ZA200708207B (en) | 2008-11-26 |
SI1866423T1 (sl) | 2012-05-31 |
AT501629B1 (de) | 2007-10-15 |
ATE542914T1 (de) | 2012-02-15 |
BRPI0607784A2 (pt) | 2009-06-13 |
JP2008534027A (ja) | 2008-08-28 |
RU2407797C2 (ru) | 2010-12-27 |
EP1866423A2 (de) | 2007-12-19 |
CA2602415A1 (en) | 2006-10-12 |
DK1866423T3 (da) | 2012-04-16 |
MX2007012315A (es) | 2007-12-11 |
RU2007140982A (ru) | 2009-05-20 |
US20090068706A1 (en) | 2009-03-12 |
KR20100110400A (ko) | 2010-10-12 |
SG160414A1 (en) | 2010-04-29 |
AT501629A1 (de) | 2006-10-15 |
AU2006230781A1 (en) | 2006-10-12 |
JP5231212B2 (ja) | 2013-07-10 |
IL186043A0 (en) | 2008-02-09 |
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