KR101132599B1 - 아폽토시스 유도 효과를 갖는 인돌 유도체 - Google Patents

아폽토시스 유도 효과를 갖는 인돌 유도체 Download PDF

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Publication number
KR101132599B1
KR101132599B1 KR1020057023347A KR20057023347A KR101132599B1 KR 101132599 B1 KR101132599 B1 KR 101132599B1 KR 1020057023347 A KR1020057023347 A KR 1020057023347A KR 20057023347 A KR20057023347 A KR 20057023347A KR 101132599 B1 KR101132599 B1 KR 101132599B1
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KR
South Korea
Prior art keywords
compound
compounds
chlorobenzyl
indol
substituted
Prior art date
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KR1020057023347A
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English (en)
Korean (ko)
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KR20060034230A (ko
Inventor
마티아스 게를라히
틸만 슈스터
페터 에미크
페터 슈미트
질케 바쓰너
엑카르트 귄터
Original Assignee
아에테르나 젠타리스 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from EP03012868A external-priority patent/EP1484329A1/de
Priority claimed from EP04011598A external-priority patent/EP1595878A1/de
Application filed by 아에테르나 젠타리스 게엠베하 filed Critical 아에테르나 젠타리스 게엠베하
Publication of KR20060034230A publication Critical patent/KR20060034230A/ko
Application granted granted Critical
Publication of KR101132599B1 publication Critical patent/KR101132599B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020057023347A 2003-06-05 2004-05-25 아폽토시스 유도 효과를 갖는 인돌 유도체 KR101132599B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US47627703P 2003-06-05 2003-06-05
US60/476,277 2003-06-05
EP03012868A EP1484329A1 (de) 2003-06-06 2003-06-06 Indolderivate mit Apoptose induzierender Wirkung
EP03012868.0 2003-06-06
EP04011598.2 2004-05-15
EP04011598A EP1595878A1 (de) 2004-05-15 2004-05-15 Indolderivate mit Apoptose induzierender Wirkung
PCT/EP2004/005593 WO2004108702A1 (de) 2003-06-05 2004-05-25 Indolderivate mit apoptose induzierender wirkung

Publications (2)

Publication Number Publication Date
KR20060034230A KR20060034230A (ko) 2006-04-21
KR101132599B1 true KR101132599B1 (ko) 2012-06-21

Family

ID=43661564

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057023347A KR101132599B1 (ko) 2003-06-05 2004-05-25 아폽토시스 유도 효과를 갖는 인돌 유도체

Country Status (12)

Country Link
EP (1) EP1641777A1 (sr)
JP (1) JP4878285B2 (sr)
KR (1) KR101132599B1 (sr)
CN (1) CN1816543B (sr)
AU (1) AU2004245198B2 (sr)
BR (1) BRPI0410998A (sr)
CA (1) CA2526663C (sr)
MX (1) MXPA05013121A (sr)
NZ (1) NZ543853A (sr)
RS (1) RS20050901A (sr)
RU (1) RU2327696C2 (sr)
WO (1) WO2004108702A1 (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
KR101400905B1 (ko) * 2005-11-11 2014-05-29 아에테르나 젠타리스 게엠베하 신규한 피리도피라진 및 키나제의 조절제로서의 이의 용도
WO2007062399A2 (en) 2005-11-23 2007-05-31 The Board Of Regents Of The University Of Texas System Oncogenic ras-specific cytotoxic compound and methods of use thereof
EP2610244A1 (en) * 2006-08-07 2013-07-03 Ironwood Pharmaceuticals, Inc. Indole compounds
EP2091532A1 (en) * 2006-11-28 2009-08-26 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
WO2010045624A1 (en) * 2008-10-16 2010-04-22 Array Biopharma Inc. Inhibitors of mitosis for increasing apoptosis in therapy
WO2012017325A2 (en) * 2010-07-19 2012-02-09 Procaps Sa Apparatus and process for encapsulating microparticles with liquid in soft gel capsules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030019295A (ko) * 1999-09-28 2003-03-06 박스터 헬쓰케어 에스.에이. 치료학적으로 유용한 인돌릴-3-글리옥실산 유도체
WO2003022280A2 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 3-glyoxlylamideindoles for treating cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
IT1318641B1 (it) * 2000-07-25 2003-08-27 Novuspharma Spa Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030019295A (ko) * 1999-09-28 2003-03-06 박스터 헬쓰케어 에스.에이. 치료학적으로 유용한 인돌릴-3-글리옥실산 유도체
WO2003022280A2 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 3-glyoxlylamideindoles for treating cancer

Also Published As

Publication number Publication date
RS20050901A (en) 2007-12-31
RU2006100022A (ru) 2006-05-27
BRPI0410998A (pt) 2006-07-04
JP4878285B2 (ja) 2012-02-15
CA2526663C (en) 2011-07-19
CN1816543A (zh) 2006-08-09
RU2327696C2 (ru) 2008-06-27
JP2007523850A (ja) 2007-08-23
NZ543853A (en) 2009-09-25
KR20060034230A (ko) 2006-04-21
WO2004108702A1 (de) 2004-12-16
EP1641777A1 (de) 2006-04-05
CA2526663A1 (en) 2004-12-16
CN1816543B (zh) 2011-01-19
AU2004245198B2 (en) 2009-04-23
AU2004245198A1 (en) 2004-12-16
MXPA05013121A (es) 2006-03-17

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