KR101119878B1 - 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포 - Google Patents

프리미티브 간 줄기세포 및 프록시멀 간 줄기세포 Download PDF

Info

Publication number
KR101119878B1
KR101119878B1 KR1020047014503A KR20047014503A KR101119878B1 KR 101119878 B1 KR101119878 B1 KR 101119878B1 KR 1020047014503 A KR1020047014503 A KR 1020047014503A KR 20047014503 A KR20047014503 A KR 20047014503A KR 101119878 B1 KR101119878 B1 KR 101119878B1
Authority
KR
South Korea
Prior art keywords
cells
stem cells
liver
delete delete
primitive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020047014503A
Other languages
English (en)
Korean (ko)
Other versions
KR20060010693A (ko
Inventor
레이드롤라
모스니콜라스지.
퍼스마크이.
루드로우존더블유.
브루스앤드류티.
Original Assignee
베스타 테라퓨틱스 인코포레이티드
유니버시티 오브 노스캐롤라이나 앳 채플 힐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베스타 테라퓨틱스 인코포레이티드, 유니버시티 오브 노스캐롤라이나 앳 채플 힐 filed Critical 베스타 테라퓨틱스 인코포레이티드
Publication of KR20060010693A publication Critical patent/KR20060010693A/ko
Application granted granted Critical
Publication of KR101119878B1 publication Critical patent/KR101119878B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020047014503A 2002-03-15 2003-03-14 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포 Expired - Fee Related KR101119878B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15
US60/365,361 2002-03-15

Publications (2)

Publication Number Publication Date
KR20060010693A KR20060010693A (ko) 2006-02-02
KR101119878B1 true KR101119878B1 (ko) 2012-03-09

Family

ID=28042021

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047014503A Expired - Fee Related KR101119878B1 (ko) 2002-03-15 2003-03-14 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포

Country Status (18)

Country Link
US (4) US7413897B2 (cg-RX-API-DMAC7.html)
EP (2) EP3023491A1 (cg-RX-API-DMAC7.html)
JP (2) JP4723811B2 (cg-RX-API-DMAC7.html)
KR (1) KR101119878B1 (cg-RX-API-DMAC7.html)
CN (3) CN1742082A (cg-RX-API-DMAC7.html)
AU (2) AU2003233399B2 (cg-RX-API-DMAC7.html)
CA (1) CA2479510C (cg-RX-API-DMAC7.html)
CY (1) CY1118167T1 (cg-RX-API-DMAC7.html)
DK (1) DK1490480T3 (cg-RX-API-DMAC7.html)
ES (1) ES2569951T3 (cg-RX-API-DMAC7.html)
HK (1) HK1209783A1 (cg-RX-API-DMAC7.html)
HU (1) HUE032238T2 (cg-RX-API-DMAC7.html)
IL (1) IL164048A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA04009031A (cg-RX-API-DMAC7.html)
PL (1) PL372619A1 (cg-RX-API-DMAC7.html)
RU (1) RU2327479C2 (cg-RX-API-DMAC7.html)
SI (1) SI1490480T1 (cg-RX-API-DMAC7.html)
WO (1) WO2003078588A2 (cg-RX-API-DMAC7.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
AU2004261899A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3D synthetic tissue
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織(Scaffold-free Self-Organized 3D synthetic tissue)
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
RU2008124158A (ru) 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников
AU2006331706A1 (en) 2005-12-22 2007-07-05 Vesta Therapeutics, Inc. Method of using hepatic progenitors in treating liver dysfunction
CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
MY146352A (en) * 2006-04-25 2012-08-15 Univ Louisiana State Adipose derived adult stem cells in hepatic regeneration
PT2029725T (pt) * 2006-05-26 2018-04-12 Univ North Carolina Chapel Hill Precursores de células hepáticas estreladas e métodos para isolar as mesmas
TW200916581A (en) * 2007-06-15 2009-04-16 Univ North Carolina Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
CA2693827A1 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US20100087000A1 (en) * 2008-05-02 2010-04-08 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
JP5822287B2 (ja) * 2008-05-14 2015-11-24 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
US20090291494A1 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells
US8877497B2 (en) * 2008-05-22 2014-11-04 Vesta Therapeutics Inc. Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
ES2819028T3 (es) * 2009-10-30 2021-04-14 Univ North Carolina Chapel Hill Células madre multipotentes del árbol biliar extrahepático y métodos para su aislamiento
US9341550B2 (en) * 2010-11-19 2016-05-17 On-Chip Biotechnologies Co., Ltd. Method for detecting low concentrations of specific cell from high concentrations of cell populations, and method for collecting and analyzing detected cell
CN103842497A (zh) * 2011-05-27 2014-06-04 德普伊新特斯产品有限责任公司 生物人工近端小管系统及使用方法
WO2013084190A1 (en) * 2011-12-08 2013-06-13 Yeda Research And Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
EP2864472A4 (en) * 2012-06-20 2015-12-30 Celula Inc MATERIALS AND METHOD FOR PROCESSING CELL POPULATIONS
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
SG10201914005TA (en) * 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
KR102338815B1 (ko) 2013-12-16 2021-12-13 프레제니우스 메디칼 케어 도이칠란드 게엠베하 췌장섬-유사 세포 구조물 및 이의 제조 방법
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
US10683484B2 (en) * 2015-06-12 2020-06-16 National University Of Singapore Derivation of hepatic stem cells and mature liver cell types and uses thereof
ES3063334T3 (en) 2015-06-18 2026-04-16 Yeda Res & Dev Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2019148143A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (clicsam)
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665589A (en) * 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
CA2115140A1 (en) 1991-08-07 1993-02-18 Lola M. Reid Proliferation of hepatocyte precursors
CA2177043C (en) * 1993-11-19 2011-08-09 Lola C.M. Reid Hepatoblasts and method of isolating same
ZA951199B (en) * 1994-02-14 1996-08-14 Kirin Brewery Protein having tpo activity
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
HK1038881A1 (zh) * 1998-04-17 2002-04-04 利思进药品公司 通过共同给予前列腺素抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
PE20001250A1 (es) * 1998-11-16 2000-11-21 Detroit Diesel Corp Metodo y sistema para el control de material devuelto
JP2000287680A (ja) * 1999-04-09 2000-10-17 Sentan Kagaku Gijutsu Incubation Center:Kk 未成熟肝細胞を成熟肝細胞へ分化させる方法
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
EP1325111A1 (en) * 2000-10-03 2003-07-09 University of North Carolina Processes for clonal growth of hepatic progenitor cells
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells

Also Published As

Publication number Publication date
US8691523B2 (en) 2014-04-08
CN1742082B (zh) 2015-01-21
EP1490480A4 (en) 2006-06-14
JP2011087591A (ja) 2011-05-06
CY1118167T1 (el) 2017-06-28
EP1490480B1 (en) 2016-02-03
WO2003078588A9 (en) 2003-12-11
RU2005125598A (ru) 2006-01-27
SI1490480T1 (sl) 2016-06-30
US20070099297A1 (en) 2007-05-03
JP2005520513A (ja) 2005-07-14
AU2008202656B2 (en) 2011-03-17
CN104630129A (zh) 2015-05-20
RU2327479C2 (ru) 2008-06-27
WO2003078588A3 (en) 2004-04-01
EP1490480A2 (en) 2004-12-29
DK1490480T3 (en) 2016-04-11
ES2569951T3 (es) 2016-05-13
US20140302601A1 (en) 2014-10-09
CA2479510A1 (en) 2003-09-25
MXPA04009031A (es) 2005-12-12
AU2008202656A8 (en) 2011-12-15
JP5463271B2 (ja) 2014-04-09
AU2008202656A1 (en) 2008-07-10
US20170096641A1 (en) 2017-04-06
AU2008202656B8 (en) 2011-12-15
KR20060010693A (ko) 2006-02-02
CN1742082A (zh) 2006-03-01
HUE032238T2 (en) 2017-09-28
WO2003078588A2 (en) 2003-09-25
US20040018621A1 (en) 2004-01-29
IL164048A0 (en) 2005-12-18
AU2003233399A1 (en) 2003-09-29
JP4723811B2 (ja) 2011-07-13
PL372619A1 (en) 2005-07-25
EP3023491A1 (en) 2016-05-25
US7413897B2 (en) 2008-08-19
AU2003233399B2 (en) 2008-03-20
CA2479510C (en) 2019-10-29
HK1209783A1 (en) 2016-04-08

Similar Documents

Publication Publication Date Title
JP5463271B2 (ja) 始原肝幹細胞および近位肝幹細胞
US6242252B1 (en) Hepatic progenitors and method of isolating same
KR101195838B1 (ko) 분리된 전분화능 성체줄기세포 및 그의 분리 및 배양 방법
CN1351656B (zh) 人肝脏祖先
JP2013039128A (ja) 幹細胞
JP2004339227A (ja) 肝臓機能不全治療剤および人工肝臓の製造方法
KR102218549B1 (ko) 인간 타액선 세포의 배양 방법
HK1225070A1 (en) Primitive and proximal hepatic stem cells
HK1225070A (en) Primitive and proximal hepatic stem cells
HK1176641B (en) Human liver progenitors
IL139319A (en) Isolated hepatocyte precursors, cell cultures containing the same, and compositions containing said cell cultures

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R19-X000 Request for party data change rejected

St.27 status event code: A-3-3-R10-R19-oth-X000

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20150209

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20160119

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20180219

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20190129

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20210218

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20210218