KR101108354B1 - Ｐｔｈ 수용체 조절제로서의 페길화된 ｐｔｈ 및 그의 용도 - Google Patents
Ｐｔｈ 수용체 조절제로서의 페길화된 ｐｔｈ 및 그의 용도 Download PDFInfo
- Publication number
- KR101108354B1 KR101108354B1 KR1020097007424A KR20097007424A KR101108354B1 KR 101108354 B1 KR101108354 B1 KR 101108354B1 KR 1020097007424 A KR1020097007424 A KR 1020097007424A KR 20097007424 A KR20097007424 A KR 20097007424A KR 101108354 B1 KR101108354 B1 KR 101108354B1
- Authority
- KR
- South Korea
- Prior art keywords
- daltons
- mpeg
- compound
- compounds
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Radar Systems Or Details Thereof (AREA)
- Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82938306P | 2006-10-13 | 2006-10-13 | |
| US60/829,383 | 2006-10-13 | ||
| PCT/US2007/080367 WO2008048784A1 (en) | 2006-10-13 | 2007-10-04 | Pegylated pth as pth receptor modulators and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20090067168A KR20090067168A (ko) | 2009-06-24 |
| KR101108354B1 true KR101108354B1 (ko) | 2012-01-25 |
Family
ID=42828673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097007424A Expired - Fee Related KR101108354B1 (ko) | 2006-10-13 | 2007-10-04 | Ｐｔｈ 수용체 조절제로서의 페길화된 ｐｔｈ 및 그의 용도 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7820179B2 (https=) |
| EP (1) | EP2084183B1 (https=) |
| JP (1) | JP5200027B2 (https=) |
| KR (1) | KR101108354B1 (https=) |
| CN (1) | CN101522709B (https=) |
| AT (1) | ATE469173T1 (https=) |
| AU (1) | AU2007313001B2 (https=) |
| BR (1) | BRPI0719885B8 (https=) |
| CA (1) | CA2672907C (https=) |
| DK (1) | DK2084183T3 (https=) |
| EA (1) | EA014696B1 (https=) |
| MX (1) | MX2009003740A (https=) |
| NO (1) | NO341986B1 (https=) |
| PL (1) | PL2084183T3 (https=) |
| SI (1) | SI2084183T1 (https=) |
| WO (1) | WO2008048784A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| MY208384A (en) * | 2016-03-01 | 2025-05-05 | Ascendis Pharma Bone Diseases As | Pth prodrugs |
| US12453778B2 (en) | 2016-09-29 | 2025-10-28 | Ascendis Pharma Bone Diseases A/S | Incremental dose finding in controlled-release PTH compounds |
| KR102627405B1 (ko) * | 2016-09-29 | 2024-01-18 | 아센디스 파마 본 디지즈 에이/에스 | 조절 방출 pth 화합물을 위한 투여 용법 |
| HRP20230383T1 (hr) * | 2016-09-29 | 2023-07-07 | Ascendis Pharma Bone Diseases A/S | Pth spojevi s malim omjerima maksimalne prema minimalnoj koncentraciji |
| WO2019232283A1 (en) | 2018-05-30 | 2019-12-05 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| MY209748A (en) | 2019-02-11 | 2025-07-31 | Ascendis Pharma Bone Diseases As | Liquid pharmaceutical formulations of pth conjugates |
| KR20250075704A (ko) | 2022-09-30 | 2025-05-28 | 익스텐드 바이오사이언시즈, 인크. | 장기-지속형 부갑상선 호르몬 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1477496A1 (en) * | 2002-02-01 | 2004-11-17 | Chugai Seiyaku Kabushiki Kaisha | Peg-conjugated pth or peg-conjugated pth derivate |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| FR2550204B1 (fr) | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| JPS6360940A (ja) | 1986-09-01 | 1988-03-17 | Toyo Jozo Co Ltd | 白内障の予防または治療剤 |
| EP0293158A3 (en) | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroid hormone antagonists |
| US4771124A (en) | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| JPH0532696A (ja) | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| JPH05271279A (ja) | 1991-08-07 | 1993-10-19 | Takeda Chem Ind Ltd | ヒト副甲状腺ホルモンムテインおよびその製造法 |
| US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| US6110892A (en) | 1994-06-20 | 2000-08-29 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| US5556940A (en) | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| US5747456A (en) | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
| US5717062A (en) | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| CA2178894A1 (en) | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Parathyroid hormone derivatives and their use |
| US6544949B1 (en) | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
| US5723577A (en) | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| US5955574A (en) | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
| DK0915911T3 (da) | 1996-08-02 | 2004-03-08 | Ca Nat Research Council | Analoger til parathyreoideahormon til behandling af osteoporose |
| HUP0003349A3 (en) | 1997-05-14 | 2001-12-28 | Aventis Pharmaceuticals Inc Co | Peptide parathyroid hormone analogs, pharmaceutical compositions comprising thereof and their use |
| EP1030658A1 (en) * | 1997-10-14 | 2000-08-30 | Eli Lilly And Company | Method of building and maintaining bone |
| NZ506839A (en) | 1998-03-09 | 2003-05-30 | Zealand Pharma As | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| CZ20003798A3 (cs) | 1998-04-15 | 2001-08-15 | Aventis Pharmaceuticals Products, Inc. | Způsob výroby cyklických peptidů vázaných k polymernímu nosiči |
| US7531621B1 (en) | 1998-05-05 | 2009-05-12 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | PTH2 receptor selective compounds |
| US6316410B1 (en) | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| US7022815B1 (en) | 1999-09-29 | 2006-04-04 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
| WO2001023521A2 (en) | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| US20050124537A1 (en) | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| AU2002339843B2 (en) | 2001-07-23 | 2007-12-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| US7799757B2 (en) | 2002-06-13 | 2010-09-21 | Michael Chorev | Analogs of parathyroid hormone and PTH-related protein as bone anabolic agents |
| TW533925U (en) | 2002-09-26 | 2003-05-21 | Lee Yeong Ind Co Ltd | Improvement of speed-changing transmission mechanism for cutting tools of drill sharpening machine |
| CA2511966A1 (en) | 2002-11-01 | 2004-07-22 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| MXPA05007151A (es) | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Polimeros terminados en maleimida hidroliticamente estables. |
| WO2004084918A1 (ja) * | 2003-03-25 | 2004-10-07 | Sekisui Chemical Co., Ltd. | 皮膚止痒外用組成物 |
| US20040220094A1 (en) | 2003-05-01 | 2004-11-04 | Skinner Keith K. | Inverse agonist and agonist peptides that stimulate/inhibit hair growth |
| EP1758927A4 (en) | 2004-01-21 | 2008-09-17 | Unigene Lab Inc | PARATHYROID HORMONE AMIDE FRAGMENTS AND USES THEREOF |
-
2007
- 2007-10-04 BR BRPI0719885A patent/BRPI0719885B8/pt not_active IP Right Cessation
- 2007-10-04 US US12/440,619 patent/US7820179B2/en not_active Expired - Fee Related
- 2007-10-04 AT AT07843791T patent/ATE469173T1/de active
- 2007-10-04 SI SI200730296T patent/SI2084183T1/sl unknown
- 2007-10-04 JP JP2009532504A patent/JP5200027B2/ja not_active Expired - Fee Related
- 2007-10-04 CN CN2007800382095A patent/CN101522709B/zh not_active Expired - Fee Related
- 2007-10-04 PL PL07843791T patent/PL2084183T3/pl unknown
- 2007-10-04 EP EP07843791A patent/EP2084183B1/en active Active
- 2007-10-04 EA EA200970376A patent/EA014696B1/ru not_active IP Right Cessation
- 2007-10-04 WO PCT/US2007/080367 patent/WO2008048784A1/en not_active Ceased
- 2007-10-04 DK DK07843791.0T patent/DK2084183T3/da active
- 2007-10-04 AU AU2007313001A patent/AU2007313001B2/en not_active Ceased
- 2007-10-04 KR KR1020097007424A patent/KR101108354B1/ko not_active Expired - Fee Related
- 2007-10-04 CA CA2672907A patent/CA2672907C/en not_active Expired - Fee Related
- 2007-10-04 MX MX2009003740A patent/MX2009003740A/es active IP Right Grant
-
2009
- 2009-04-28 NO NO20091691A patent/NO341986B1/no not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1477496A1 (en) * | 2002-02-01 | 2004-11-17 | Chugai Seiyaku Kabushiki Kaisha | Peg-conjugated pth or peg-conjugated pth derivate |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20091691L (no) | 2009-05-11 |
| EP2084183A1 (en) | 2009-08-05 |
| US20090253630A1 (en) | 2009-10-08 |
| CA2672907A1 (en) | 2008-04-24 |
| BRPI0719885B8 (pt) | 2021-05-25 |
| ATE469173T1 (de) | 2010-06-15 |
| AU2007313001B2 (en) | 2012-03-22 |
| CN101522709B (zh) | 2013-03-20 |
| MX2009003740A (es) | 2009-04-22 |
| PL2084183T3 (pl) | 2010-10-29 |
| BRPI0719885A2 (pt) | 2014-04-29 |
| US7820179B2 (en) | 2010-10-26 |
| AU2007313001A1 (en) | 2008-04-24 |
| JP5200027B2 (ja) | 2013-05-15 |
| SI2084183T1 (sl) | 2010-09-30 |
| KR20090067168A (ko) | 2009-06-24 |
| DK2084183T3 (da) | 2010-08-16 |
| CA2672907C (en) | 2013-08-06 |
| EA200970376A1 (ru) | 2009-10-30 |
| EA014696B1 (ru) | 2010-12-30 |
| EP2084183B1 (en) | 2010-05-26 |
| JP2010506844A (ja) | 2010-03-04 |
| WO2008048784A1 (en) | 2008-04-24 |
| CN101522709A (zh) | 2009-09-02 |
| NO341986B1 (no) | 2018-03-12 |
| BRPI0719885B1 (pt) | 2018-12-11 |
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