KR101086654B1 - 신규 헤테로아릴 유도체 - Google Patents

신규 헤테로아릴 유도체 Download PDF

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Publication number
KR101086654B1
KR101086654B1 KR1020067000907A KR20067000907A KR101086654B1 KR 101086654 B1 KR101086654 B1 KR 101086654B1 KR 1020067000907 A KR1020067000907 A KR 1020067000907A KR 20067000907 A KR20067000907 A KR 20067000907A KR 101086654 B1 KR101086654 B1 KR 101086654B1
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KR
South Korea
Prior art keywords
straight
group
branched
mmol
compound
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KR1020067000907A
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English (en)
Korean (ko)
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KR20060040681A (ko
Inventor
겐-이치 와타나베
가츠노리 마루타
간타로 우시로다
류 나가타
Original Assignee
다이닛본 스미토모 세이야꾸 가부시끼가이샤
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Publication of KR20060040681A publication Critical patent/KR20060040681A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
KR1020067000907A 2003-07-15 2004-07-13 신규 헤테로아릴 유도체 Expired - Fee Related KR101086654B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003274684 2003-07-15
JPJP-P-2003-00274684 2003-07-15
PCT/JP2004/010282 WO2005012245A1 (ja) 2003-07-15 2004-07-13 新規ヘテロアリール誘導体

Publications (2)

Publication Number Publication Date
KR20060040681A KR20060040681A (ko) 2006-05-10
KR101086654B1 true KR101086654B1 (ko) 2011-11-24

Family

ID=34113749

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067000907A Expired - Fee Related KR101086654B1 (ko) 2003-07-15 2004-07-13 신규 헤테로아릴 유도체

Country Status (11)

Country Link
US (2) US7425642B2 (https=)
EP (1) EP1647546B1 (https=)
JP (2) JP4820169B2 (https=)
KR (1) KR101086654B1 (https=)
CN (1) CN100516041C (https=)
AT (1) ATE556051T1 (https=)
CA (1) CA2531064C (https=)
ES (1) ES2383895T3 (https=)
MX (1) MXPA06000539A (https=)
TW (1) TW200523249A (https=)
WO (1) WO2005012245A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006075638A1 (ja) * 2005-01-14 2006-07-20 Dainippon Sumitomo Pharma Co., Ltd. 新規ヘテロアリール誘導体
US20060241073A1 (en) * 2005-04-20 2006-10-26 Wanders Ronaldus J A Means and methods for counteracting fatty acid accumulation
TWI386405B (zh) 2006-09-05 2013-02-21 咪唑衍生物
WO2008157537A2 (en) * 2007-06-19 2008-12-24 Ironwood Pharmaceuticals, Inc Compositions and methods of use for treating or preventing lipid related disorders
CN102202662A (zh) * 2008-10-31 2011-09-28 大日本住友制药株式会社 抗糖尿病剂
US20120010264A1 (en) * 2009-03-26 2012-01-12 Dainippon Sumitomo Pharma Co., Ltd. Novel medicament for treating cognitive impairment
WO2011002012A1 (ja) * 2009-07-01 2011-01-06 大日本住友製薬株式会社 Sglt1阻害薬とインスリン抵抗性改善薬を組み合わせてなる医薬
KR20120117905A (ko) 2010-01-28 2012-10-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로테아좀 활성을 향상시키는 조성물 및 방법
JP5996532B2 (ja) 2010-07-15 2016-09-21 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 有害生物防除剤としての新規複素環式化合物
HUE044867T2 (hu) 2011-05-12 2019-11-28 Proteostasis Therapeutics Inc Proteosztázis szabályzók
US10266490B2 (en) * 2012-03-16 2019-04-23 Georgetown University Radioprotector compounds
US9849135B2 (en) 2013-01-25 2017-12-26 President And Fellows Of Harvard College USP14 inhibitors for treating or preventing viral infections
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514631A (ja) 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
WO2002000661A1 (en) 2000-06-26 2002-01-03 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
JP2002121186A (ja) 2000-05-22 2002-04-23 Takeda Chem Ind Ltd チロシンホスファターゼ阻害剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752361A1 (de) * 1977-11-24 1979-06-07 Troponwerke Gmbh & Co Kg Neue indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6177443B1 (en) 1997-03-07 2001-01-23 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
EP1284260A4 (en) 2000-05-22 2004-03-31 Takeda Chemical Industries Ltd TYROSIN PHOSPHATASE INHIBITORS
EP1386913B1 (en) * 2001-04-19 2008-07-16 Dainippon Sumitomo Pharma Co., Ltd. Pyrrole derivative
JP2003171275A (ja) 2001-12-11 2003-06-17 Sumitomo Pharmaceut Co Ltd ＰＰＡＲδアゴニスト
JPWO2004048341A1 (ja) 2002-11-28 2006-03-23 住友製薬株式会社 新規ヘテロアリール誘導体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514631A (ja) 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
JP2002121186A (ja) 2000-05-22 2002-04-23 Takeda Chem Ind Ltd チロシンホスファターゼ阻害剤
WO2002000661A1 (en) 2000-06-26 2002-01-03 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS

Also Published As

Publication number Publication date
CN1849303A (zh) 2006-10-18
JP2011251974A (ja) 2011-12-15
TWI331142B (https=) 2010-10-01
KR20060040681A (ko) 2006-05-10
EP1647546A1 (en) 2006-04-19
US20060194857A1 (en) 2006-08-31
US7425642B2 (en) 2008-09-16
US20080306275A1 (en) 2008-12-11
WO2005012245A1 (ja) 2005-02-10
JPWO2005012245A1 (ja) 2006-09-14
CN100516041C (zh) 2009-07-22
CA2531064A1 (en) 2005-02-10
MXPA06000539A (es) 2006-03-30
TW200523249A (en) 2005-07-16
JP4820169B2 (ja) 2011-11-24
CA2531064C (en) 2012-05-22
ATE556051T1 (de) 2012-05-15
EP1647546A4 (en) 2008-07-23
ES2383895T3 (es) 2012-06-27
HK1087409A1 (en) 2006-10-13
EP1647546B1 (en) 2012-05-02

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