KR101086654B1 - 신규 헤테로아릴 유도체 - Google Patents

신규 헤테로아릴 유도체 Download PDF

Info

Publication number
KR101086654B1
KR101086654B1 KR1020067000907A KR20067000907A KR101086654B1 KR 101086654 B1 KR101086654 B1 KR 101086654B1 KR 1020067000907 A KR1020067000907 A KR 1020067000907A KR 20067000907 A KR20067000907 A KR 20067000907A KR 101086654 B1 KR101086654 B1 KR 101086654B1
Authority
KR
South Korea
Prior art keywords
straight
group
branched
mmol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020067000907A
Other languages
English (en)
Korean (ko)
Other versions
KR20060040681A (ko
Inventor
겐-이치 와타나베
가츠노리 마루타
간타로 우시로다
류 나가타
Original Assignee
다이닛본 스미토모 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 다이닛본 스미토모 세이야꾸 가부시끼가이샤 filed Critical 다이닛본 스미토모 세이야꾸 가부시끼가이샤
Publication of KR20060040681A publication Critical patent/KR20060040681A/ko
Application granted granted Critical
Publication of KR101086654B1 publication Critical patent/KR101086654B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
KR1020067000907A 2003-07-15 2004-07-13 신규 헤테로아릴 유도체 Expired - Fee Related KR101086654B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003274684 2003-07-15
JPJP-P-2003-00274684 2003-07-15
PCT/JP2004/010282 WO2005012245A1 (ja) 2003-07-15 2004-07-13 新規ヘテロアリール誘導体

Publications (2)

Publication Number Publication Date
KR20060040681A KR20060040681A (ko) 2006-05-10
KR101086654B1 true KR101086654B1 (ko) 2011-11-24

Family

ID=34113749

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067000907A Expired - Fee Related KR101086654B1 (ko) 2003-07-15 2004-07-13 신규 헤테로아릴 유도체

Country Status (11)

Country Link
US (2) US7425642B2 (https=)
EP (1) EP1647546B1 (https=)
JP (2) JP4820169B2 (https=)
KR (1) KR101086654B1 (https=)
CN (1) CN100516041C (https=)
AT (1) ATE556051T1 (https=)
CA (1) CA2531064C (https=)
ES (1) ES2383895T3 (https=)
MX (1) MXPA06000539A (https=)
TW (1) TW200523249A (https=)
WO (1) WO2005012245A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006075638A1 (ja) * 2005-01-14 2008-06-12 大日本住友製薬株式会社 新規ヘテロアリール誘導体
US20060241073A1 (en) * 2005-04-20 2006-10-26 Wanders Ronaldus J A Means and methods for counteracting fatty acid accumulation
AU2007292155B2 (en) 2006-09-05 2012-11-01 Kyowa Kirin Co., Ltd. Imidazole derivative
WO2008157537A2 (en) * 2007-06-19 2008-12-24 Ironwood Pharmaceuticals, Inc Compositions and methods of use for treating or preventing lipid related disorders
JPWO2010050422A1 (ja) * 2008-10-31 2012-03-29 大日本住友製薬株式会社 糖尿病治療剤
US20120010264A1 (en) * 2009-03-26 2012-01-12 Dainippon Sumitomo Pharma Co., Ltd. Novel medicament for treating cognitive impairment
JPWO2011002012A1 (ja) * 2009-07-01 2012-12-13 キッセイ薬品工業株式会社 Ｓｇｌｔ１阻害薬とインスリン抵抗性改善薬を組み合わせてなる医薬
MX336731B (es) 2010-01-28 2016-01-28 Harvard College Composiciones y metodos para potenciar la actividad de proteasoma.
WO2012007500A2 (de) 2010-07-15 2012-01-19 Bayer Cropscience Ag Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel
DK2707101T3 (da) 2011-05-12 2019-05-13 Proteostasis Therapeutics Inc Proteostaseregulatorer
US10266490B2 (en) * 2012-03-16 2019-04-23 Georgetown University Radioprotector compounds
US9849135B2 (en) 2013-01-25 2017-12-26 President And Fellows Of Harvard College USP14 inhibitors for treating or preventing viral infections
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514631A (ja) 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
WO2002000661A1 (en) 2000-06-26 2002-01-03 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
JP2002121186A (ja) 2000-05-22 2002-04-23 Takeda Chem Ind Ltd チロシンホスファターゼ阻害剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752361A1 (de) * 1977-11-24 1979-06-07 Troponwerke Gmbh & Co Kg Neue indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6177443B1 (en) * 1997-03-07 2001-01-23 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
US6911468B2 (en) * 2000-05-22 2005-06-28 Takeda Chemical Industries, Ltd. Tyrosine phosphatase inhibitors
DE60227655D1 (de) * 2001-04-19 2008-08-28 Dainippon Sumitomo Pharma Co Pyrrolderivat
JP2003171275A (ja) 2001-12-11 2003-06-17 Sumitomo Pharmaceut Co Ltd ＰＰＡＲδアゴニスト
AU2003284479A1 (en) 2002-11-28 2004-06-18 Sumitomo Pharmaceuticals Co., Ltd. Novel heteroaryl derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514631A (ja) 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
JP2002121186A (ja) 2000-05-22 2002-04-23 Takeda Chem Ind Ltd チロシンホスファターゼ阻害剤
WO2002000661A1 (en) 2000-06-26 2002-01-03 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS

Also Published As

Publication number Publication date
WO2005012245A1 (ja) 2005-02-10
CA2531064C (en) 2012-05-22
US20080306275A1 (en) 2008-12-11
US20060194857A1 (en) 2006-08-31
CA2531064A1 (en) 2005-02-10
ATE556051T1 (de) 2012-05-15
US7425642B2 (en) 2008-09-16
ES2383895T3 (es) 2012-06-27
EP1647546A4 (en) 2008-07-23
HK1087409A1 (en) 2006-10-13
CN1849303A (zh) 2006-10-18
JPWO2005012245A1 (ja) 2006-09-14
KR20060040681A (ko) 2006-05-10
JP2011251974A (ja) 2011-12-15
CN100516041C (zh) 2009-07-22
MXPA06000539A (es) 2006-03-30
TW200523249A (en) 2005-07-16
EP1647546A1 (en) 2006-04-19
TWI331142B (https=) 2010-10-01
JP4820169B2 (ja) 2011-11-24
EP1647546B1 (en) 2012-05-02

Similar Documents

Publication Publication Date Title
US20080306275A1 (en) Novel heteroaryl derivative
EP1194144B1 (en) Antibacterial compounds
JP3997491B2 (ja) カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩
SK1182004A3 (sk) Perorálne antidiabetické činidlá
US20100286144A1 (en) Heteroaryl derivatives
US20160355475A1 (en) Novel indole derivative compound and pharmaceutical composition comprising the same
CA2730078A1 (en) Nitrogen-containing aromatic heterocyclyl compound
JP2001151771A (ja) 含窒素芳香族複素環誘導体
KR20220141331A (ko) P2x3 조정제
KR102029516B1 (ko) 아자 아다만탄의 유도체 및 이의 용도
US8063090B2 (en) Mineralocorticoid receptor modulators
JPWO2003091211A1 (ja) 新規ヘテロアリール化合物
KR100592805B1 (ko) 인덴 유도체 및 이의 제조방법
US7220773B2 (en) Pyrrole derivative
JP2006182668A (ja) 高脂質症、動脈硬化、および／またはメタボリックシンドローム治療剤
KR20080065674A (ko) 신규한 인돌 함유 베타 효능제, 이의 제조 방법 및약제로서의 이의 용도
WO2004048341A1 (ja) 新規ヘテロアリール誘導体
HK1087409B (en) Novel heteroaryl derivative
JP3836521B2 (ja) ２，４−チアゾリジンジオン誘導体、その製造法およびそれを含んでなる医薬組成物
JP2006036730A (ja) 新規ピロール誘導体

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20141119

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20141119

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000