KR101078919B1 - 신규한 스트렙토코커스 항원 - Google Patents
신규한 스트렙토코커스 항원 Download PDFInfo
- Publication number
- KR101078919B1 KR101078919B1 KR1020107009285A KR20107009285A KR101078919B1 KR 101078919 B1 KR101078919 B1 KR 101078919B1 KR 1020107009285 A KR1020107009285 A KR 1020107009285A KR 20107009285 A KR20107009285 A KR 20107009285A KR 101078919 B1 KR101078919 B1 KR 101078919B1
- Authority
- KR
- South Korea
- Prior art keywords
- polypeptide
- seq
- bvh
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11380098P | 1998-12-23 | 1998-12-23 | |
| US60/113,800 | 1998-12-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087008264A Division KR101170203B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100063814A KR20100063814A (ko) | 2010-06-11 |
| KR101078919B1 true KR101078919B1 (ko) | 2011-11-01 |
Family
ID=22351610
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107009285A Expired - Fee Related KR101078919B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
| KR1020067025282A Expired - Fee Related KR100891398B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
| KR1020087008264A Expired - Fee Related KR101170203B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
| KR1020017007963A Expired - Fee Related KR100802198B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067025282A Expired - Fee Related KR100891398B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
| KR1020087008264A Expired - Fee Related KR101170203B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
| KR1020017007963A Expired - Fee Related KR100802198B1 (ko) | 1998-12-23 | 1999-12-20 | 신규한 스트렙토코커스 항원 |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP1141306B1 (enExample) |
| JP (2) | JP4761623B2 (enExample) |
| KR (4) | KR101078919B1 (enExample) |
| CN (3) | CN101134775A (enExample) |
| AP (1) | AP2001002199A0 (enExample) |
| AR (1) | AR029322A1 (enExample) |
| AT (1) | ATE394489T1 (enExample) |
| AU (1) | AU1764900A (enExample) |
| BR (1) | BR9916477A (enExample) |
| CA (1) | CA2356836C (enExample) |
| CL (1) | CL2009002037A1 (enExample) |
| CY (3) | CY1108223T1 (enExample) |
| CZ (2) | CZ303675B6 (enExample) |
| DE (1) | DE69938670D1 (enExample) |
| DK (3) | DK1141306T3 (enExample) |
| EA (1) | EA007409B1 (enExample) |
| ES (3) | ES2480417T3 (enExample) |
| HU (1) | HU229664B1 (enExample) |
| IL (3) | IL143905A0 (enExample) |
| MX (1) | MXPA01006427A (enExample) |
| NO (1) | NO330800B1 (enExample) |
| NZ (1) | NZ512574A (enExample) |
| OA (1) | OA11736A (enExample) |
| PL (3) | PL206576B1 (enExample) |
| PT (3) | PT1141306E (enExample) |
| TR (2) | TR200200633T2 (enExample) |
| UY (1) | UY25877A1 (enExample) |
| WO (1) | WO2000039299A2 (enExample) |
| ZA (1) | ZA200105114B (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2000001886A0 (en) | 1998-02-20 | 2000-09-30 | Iaf Biochem Int | Group B streptococcus antigens. |
| EP1801218A3 (en) * | 1998-07-27 | 2007-10-10 | Sanofi Pasteur Limited | Nucleic acids and proteins from streptococcus pneumoniae |
| US20030134407A1 (en) | 1998-07-27 | 2003-07-17 | Le Page Richard William Falla | Nucleic acids and proteins from Streptococcus pneumoniae |
| US6582706B1 (en) | 1998-12-21 | 2003-06-24 | Medimmune, Inc. | Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural MOTIFS |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| EA007409B1 (ru) * | 1998-12-23 | 2006-10-27 | Шайе Биокем Инк. | Антигенные полипептиды стрептококков, способы их получения и применения |
| DE60136356D1 (de) * | 2000-06-12 | 2008-12-11 | Univ Saskatchewan | Chimäres GapC Protein aus Streptococcus und dessen Verwendung zur Impfung und Diagnostik |
| US6866855B2 (en) | 2000-06-12 | 2005-03-15 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| US6833134B2 (en) | 2000-06-12 | 2004-12-21 | University Of Saskacthewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| EP2281891A3 (en) * | 2000-06-20 | 2011-08-17 | ID Biomedical Corporation | Streptococcus antigens |
| US7074415B2 (en) | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
| WO2002079475A2 (en) * | 2001-03-30 | 2002-10-10 | Shire Biochem Inc. | Streptococcus pyogenes antigens and corresponding dna fragments |
| AU2002317107B2 (en) | 2001-07-06 | 2008-06-12 | Id Biomedical Corporation | Group B streptococcus antigens and corresponding DNA fragments |
| GB0130228D0 (en) * | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
| US7262024B2 (en) | 2001-12-20 | 2007-08-28 | Id Biomedical Corporation | Streptococcus antigens |
| AU2004218284B2 (en) | 2003-03-04 | 2009-07-23 | Intercell Ag | Streptococcus pyogenes antigens |
| EP2311987A1 (en) * | 2003-04-15 | 2011-04-20 | Intercell AG | S. pneumoniae antigens |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| DK2384765T3 (en) | 2005-12-22 | 2017-01-09 | Glaxosmithkline Biologicals Sa | Vaccine against Streptococcus pneumoniae. |
| EP2687228B1 (en) | 2007-06-26 | 2017-07-19 | GlaxoSmithKline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
| ES2397488T3 (es) * | 2007-07-23 | 2013-03-07 | Sanofi Pasteur Limited | Polipéptidos inmunógenos y anticuerpos monoclonales |
| ES2678694T3 (es) | 2008-04-16 | 2018-08-16 | Glaxosmithkline Biologicals Sa | Vacuna |
| CN102223876A (zh) | 2008-09-26 | 2011-10-19 | 纳米生物公司 | 纳米乳剂治疗性组合物及其使用方法 |
| KR101450958B1 (ko) | 2009-04-30 | 2014-10-15 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 폐렴구균 백신 및 그의 용도 |
| WO2010132833A1 (en) | 2009-05-14 | 2010-11-18 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
| EP3358008A1 (en) | 2009-09-03 | 2018-08-08 | Pfizer Vaccines LLC | Pcsk9 vaccine |
| GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| KR20140009281A (ko) | 2010-12-03 | 2014-01-22 | 사노피 파스퇴르 리미티드 / 사노피 파스퇴르 리미떼 | 스트렙토코커스 뉴모니애에 대한 면역화를 위한 조성물 |
| MY163871A (en) * | 2011-01-20 | 2017-10-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
| EP2680883B1 (en) | 2011-03-02 | 2018-09-05 | Pfizer Inc | Pcsk9 vaccine |
| WO2012156391A1 (en) | 2011-05-17 | 2012-11-22 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| CA2859078A1 (en) * | 2012-01-05 | 2013-07-11 | Deutsches Krebsforschungszentrum | Means and methods for treating or diagnosing idh1 r132h mutant-positive cancers |
| EP2931743A4 (en) * | 2012-12-14 | 2016-08-03 | Sanofi Pasteur Ltd | METHOD FOR ASSESSING IMMUNOGENICITY |
| HRP20211288T1 (hr) | 2014-01-21 | 2021-11-26 | Pfizer Inc. | Kapsularni polisaharidi bakterije streptococcus pneumoniae i njihovi konjugati |
| EP3096785B1 (en) | 2014-01-21 | 2020-09-09 | Pfizer Inc | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| PT3096783T (pt) | 2014-01-21 | 2021-08-16 | Pfizer | Polissacáridos capsulares de streptococcus pneumoniae e conjugados dos mesmos |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| EP3443983B1 (en) | 2014-02-14 | 2022-07-20 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
| CN107427568B (zh) | 2015-01-15 | 2021-12-14 | 辉瑞公司 | 用于肺炎球菌疫苗中的免疫原性组合物 |
| IL303998A (en) | 2015-07-21 | 2023-08-01 | Pfizer | Immunogenic preparations containing conjugated capsular sugar antigens, kits containing them and their uses |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| EP3377098A1 (en) | 2015-11-20 | 2018-09-26 | Pfizer Inc | Immunogenic compositions for use in pneumococcal vaccines |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| WO2018134693A1 (en) | 2017-01-20 | 2018-07-26 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| US20220016229A1 (en) | 2018-12-12 | 2022-01-20 | Pfizer Inc. | Immunogenic Multiple Hetero-Antigen Polysaccharide-Protein Conjugates and uses thereof |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| CA3136278A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| US20220265803A1 (en) | 2019-07-31 | 2022-08-25 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same |
| MX2022005252A (es) | 2019-11-01 | 2022-06-08 | Pfizer | Composiciones de escherichia coli y metodos de las mismas. |
| JP2021132644A (ja) | 2020-02-21 | 2021-09-13 | ファイザー・インク | 糖の精製 |
| IL295632A (en) | 2020-02-23 | 2022-10-01 | Pfizer | Escherichia coli preparations and their methods |
| WO2022084852A1 (en) | 2020-10-22 | 2022-04-28 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| EP4237428A2 (en) | 2020-10-27 | 2023-09-06 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| US12138302B2 (en) | 2020-10-27 | 2024-11-12 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| US20240000912A1 (en) | 2020-11-04 | 2024-01-04 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| US12357681B2 (en) | 2020-12-23 | 2025-07-15 | Pfizer Inc. | E. coli FimH mutants and uses thereof |
| WO2022234405A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| JP2024521847A (ja) | 2021-05-28 | 2024-06-04 | ファイザー・インク | コンジュゲート化莢膜糖抗原を含む免疫原性組成物およびその使用 |
| CA3221074A1 (en) | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| JP2025508749A (ja) | 2022-01-13 | 2025-04-10 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
| WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
| CA3256617A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | PROCESS FOR PRODUCING VACCINE FORMULATIONS WITH PRESERVATIVES |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
| PE20251701A1 (es) | 2022-11-22 | 2025-07-02 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos |
| KR20250113501A (ko) | 2022-12-01 | 2025-07-25 | 화이자 인코포레이티드 | 폐렴구균 접합체 백신 제형 |
| EP4661911A1 (en) | 2023-02-10 | 2025-12-17 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024201324A2 (en) | 2023-03-30 | 2024-10-03 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024255922A1 (en) | 2023-04-14 | 2025-10-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024241172A2 (en) | 2023-05-19 | 2024-11-28 | Glaxosmithkline Biologicals Sa | Methods for eliciting an immune response to respiratory syncycial virus and streptococcus pneumoniae infection |
| WO2025057078A1 (en) | 2023-09-14 | 2025-03-20 | Pfizer Inc. | Adjuvanted immunogenic compositions comprising conjugated pneumococcal capsular saccharide antigens and uses thereof |
| WO2025133971A1 (en) | 2023-12-23 | 2025-06-26 | Pfizer Inc. | Improved methods for producing bacterial capsular saccharide glycoconjugates |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025191415A1 (en) | 2024-03-11 | 2025-09-18 | Pfizer Inc. | Immunogenic compositions comprising conjugated escherichia coli saccharides and uses thereof |
| WO2025219908A2 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Media and fermentation methods for polysaccharide production in bacterial cell culture |
| WO2025219904A1 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998018930A2 (en) | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae antigens and vaccines |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
| DE69432658T2 (de) * | 1993-03-19 | 2004-04-08 | Gunnar Lindahl | Rib-protein, ein oberflächenprotein welches immunität gegen viele streptococcus-stämme der gruppe b verleiht, reinigungsverfahren für das rib-protein, testsatz und pharmazeutische zusammenstellung (arznei) |
| WO1996040928A1 (en) * | 1995-06-07 | 1996-12-19 | Biochem Vaccines Inc. | Streptococcal heat shock proteins members of the hsp70 family |
| US5928895A (en) * | 1996-09-24 | 1999-07-27 | Smithkline Beecham Corporation | IgA Fc binding protein |
| US5882896A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
| CA2305016A1 (en) * | 1997-09-24 | 1999-04-01 | Regents Of The University Of Minnesota | Human complement c3-degrading proteinase from streptococcus pneumoniae |
| AU770378B2 (en) * | 1998-04-23 | 2004-02-19 | Uab Research Foundation | Pneumococcal surface protein C(PspC), epitopic regions and strain selection thereof, and uses therefor |
| CN1318103A (zh) * | 1998-07-27 | 2001-10-17 | 微生物技术有限公司 | 肺炎链球菌的核酸和蛋白质 |
| ATE361365T1 (de) * | 1998-07-27 | 2007-05-15 | Sanofi Pasteur Ltd | Streptococcus pneumoniae proteine und nukleinsäuren |
| BR9914066A (pt) * | 1998-09-24 | 2002-04-23 | Univ Minnesota | Polipeptìdio degradador de c3 de complemento humano de streptococcus pneumoniae |
| US6582706B1 (en) * | 1998-12-21 | 2003-06-24 | Medimmune, Inc. | Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural MOTIFS |
| EA007409B1 (ru) * | 1998-12-23 | 2006-10-27 | Шайе Биокем Инк. | Антигенные полипептиды стрептококков, способы их получения и применения |
-
1999
- 1999-12-20 EA EA200100565A patent/EA007409B1/ru not_active IP Right Cessation
- 1999-12-20 AU AU17649/00A patent/AU1764900A/en not_active Abandoned
- 1999-12-20 AT AT99960748T patent/ATE394489T1/de active
- 1999-12-20 BR BR9916477-9A patent/BR9916477A/pt active Search and Examination
- 1999-12-20 ES ES10180372.4T patent/ES2480417T3/es not_active Expired - Lifetime
- 1999-12-20 KR KR1020107009285A patent/KR101078919B1/ko not_active Expired - Fee Related
- 1999-12-20 DK DK99960748T patent/DK1141306T3/da active
- 1999-12-20 TR TR2002/00633T patent/TR200200633T2/xx unknown
- 1999-12-20 PT PT99960748T patent/PT1141306E/pt unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1998018930A2 (en) | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae antigens and vaccines |
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| US7262024B2 (en) | Streptococcus antigens | |
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