KR101072237B1 - 2-시아노-3-하이드록시-ｎ-(페닐)부트-2-엔 아미드의제조방법 - Google Patents

2-시아노-3-하이드록시-ｎ-(페닐)부트-2-엔 아미드의제조방법 Download PDF

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KR101072237B1
KR101072237B1 KR1020057017413A KR20057017413A KR101072237B1 KR 101072237 B1 KR101072237 B1 KR 101072237B1 KR 1020057017413 A KR1020057017413 A KR 1020057017413A KR 20057017413 A KR20057017413 A KR 20057017413A KR 101072237 B1 KR101072237 B1 KR 101072237B1
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South Korea
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formula
compound
phenyl
cyano
process according
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Korean (ko)
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KR20050120647A (ko
Inventor
요헨 하흐텔
베른트 나이세스
빌프리트 슈밥
롤란트 우츠
마르틴 찬
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사노피-아벤티스 도이칠란트 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/26—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020057017413A 2003-03-18 2004-03-06 2-시아노-3-하이드록시-ｎ-(페닐)부트-2-엔 아미드의제조방법 Expired - Lifetime KR101072237B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10311763A DE10311763A1 (de) 2003-03-18 2003-03-18 Verfahren zur Herstellung von 2-Cyan-3-hydroxy-N-(phenyl)but-2-enamiden
DE10311763.6 2003-03-18
PCT/EP2004/002311 WO2004083165A1 (de) 2003-03-18 2004-03-06 Verfahren zur hertellung von 2-cyan-3-hydroxy-n-(phenyl)but-2-enamiden

Publications (2)

Publication Number Publication Date
KR20050120647A KR20050120647A (ko) 2005-12-22
KR101072237B1 true KR101072237B1 (ko) 2011-10-12

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Family Applications (1)

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KR1020057017413A Expired - Lifetime KR101072237B1 (ko) 2003-03-18 2004-03-06 2-시아노-3-하이드록시-ｎ-(페닐)부트-2-엔 아미드의제조방법

Country Status (20)

Country Link
EP (1) EP1606246B1 (enExample)
JP (1) JP4546952B2 (enExample)
KR (1) KR101072237B1 (enExample)
CN (1) CN100361967C (enExample)
AR (1) AR043624A1 (enExample)
AT (1) ATE468323T1 (enExample)
AU (1) AU2004222139B2 (enExample)
CA (1) CA2519209C (enExample)
CY (1) CY1110722T1 (enExample)
DE (2) DE10311763A1 (enExample)
DK (1) DK1606246T3 (enExample)
ES (1) ES2346215T3 (enExample)
IL (1) IL170934A (enExample)
MX (1) MXPA05009764A (enExample)
PL (1) PL1606246T3 (enExample)
PT (1) PT1606246E (enExample)
RU (1) RU2330838C2 (enExample)
SI (1) SI1606246T1 (enExample)
TW (1) TW200503995A (enExample)
WO (1) WO2004083165A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2724861A1 (en) 2008-06-05 2009-12-10 Alembic Limited A process for preparing teriflunomide
WO2013113035A1 (en) * 2012-01-28 2013-08-01 Optmed, Inc. Improved methylidene malonate process
CN104995166A (zh) * 2013-01-29 2015-10-21 Opt迈德有限公司 改进的1,1-二取代的乙烯方法
CN104693070A (zh) * 2013-12-10 2015-06-10 深圳翰宇药业股份有限公司 一种特立氟胺的合成方法
CN105272882B (zh) * 2014-07-23 2019-05-31 欣凯医药化工中间体（上海）有限公司 一种环保简便制备泰瑞米特的方法
CN116924937A (zh) * 2022-04-02 2023-10-24 江苏康缘药业股份有限公司 2-氰基-3-羟基-2-丁烯-(4-三氟甲基-苯基)酰胺制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
DE19636974A1 (de) * 1996-09-12 1998-03-19 Hoechst Ag 2-Cyano-3,5-dihydroxy-hex-2-en- carbonsäureamidderivate
WO2002034251A1 (en) * 2000-10-20 2002-05-02 Parker Hughes Institute Treatment of asthma with lfm analogues

Also Published As

Publication number Publication date
CN1756737A (zh) 2006-04-05
DE502004011176D1 (de) 2010-07-01
HK1086818A1 (zh) 2006-09-29
IL170934A (en) 2009-11-18
ATE468323T1 (de) 2010-06-15
KR20050120647A (ko) 2005-12-22
RU2005132162A (ru) 2006-02-10
DE10311763A1 (de) 2004-10-07
CY1110722T1 (el) 2015-06-10
EP1606246B1 (de) 2010-05-19
PT1606246E (pt) 2010-07-21
RU2330838C2 (ru) 2008-08-10
AU2004222139A1 (en) 2004-09-30
EP1606246A1 (de) 2005-12-21
CN100361967C (zh) 2008-01-16
PL1606246T3 (pl) 2010-10-29
CA2519209A1 (en) 2004-09-30
MXPA05009764A (es) 2005-10-26
SI1606246T1 (sl) 2010-08-31
AR043624A1 (es) 2005-08-03
WO2004083165A1 (de) 2004-09-30
CA2519209C (en) 2011-12-06
TW200503995A (en) 2005-02-01
ES2346215T3 (es) 2010-10-13
JP4546952B2 (ja) 2010-09-22
JP2006520345A (ja) 2006-09-07
DK1606246T3 (da) 2010-09-06
AU2004222139B2 (en) 2010-03-04

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