SI1606246T1 - Postopek za pripravo 2-cian-3-hidroksi-N-(fenil)but-2-enamidov - Google Patents

Postopek za pripravo 2-cian-3-hidroksi-N-(fenil)but-2-enamidov

Info

Publication number
SI1606246T1
SI1606246T1 SI200431463T SI200431463T SI1606246T1 SI 1606246 T1 SI1606246 T1 SI 1606246T1 SI 200431463 T SI200431463 T SI 200431463T SI 200431463 T SI200431463 T SI 200431463T SI 1606246 T1 SI1606246 T1 SI 1606246T1
Authority
SI
Slovenia
Prior art keywords
cyan
hydroxy
phenyl
producing
ene
Prior art date
Application number
SI200431463T
Other languages
English (en)
Slovenian (sl)
Inventor
Jochen Hachtel
Bernd Neises
Wilfried Schwab
Roland Utz
Martin Zahn
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of SI1606246T1 publication Critical patent/SI1606246T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/26—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200431463T 2003-03-18 2004-03-06 Postopek za pripravo 2-cian-3-hidroksi-N-(fenil)but-2-enamidov SI1606246T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10311763A DE10311763A1 (de) 2003-03-18 2003-03-18 Verfahren zur Herstellung von 2-Cyan-3-hydroxy-N-(phenyl)but-2-enamiden
PCT/EP2004/002311 WO2004083165A1 (de) 2003-03-18 2004-03-06 Verfahren zur hertellung von 2-cyan-3-hydroxy-n-(phenyl)but-2-enamiden
EP04718192A EP1606246B1 (de) 2003-03-18 2004-03-06 Verfahren zur hertellung von 2-cyan-3-hydroxy-n-(phenyl)but-2-enamiden

Publications (1)

Publication Number Publication Date
SI1606246T1 true SI1606246T1 (sl) 2010-08-31

Family

ID=32945937

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431463T SI1606246T1 (sl) 2003-03-18 2004-03-06 Postopek za pripravo 2-cian-3-hidroksi-N-(fenil)but-2-enamidov

Country Status (20)

Country Link
EP (1) EP1606246B1 (enExample)
JP (1) JP4546952B2 (enExample)
KR (1) KR101072237B1 (enExample)
CN (1) CN100361967C (enExample)
AR (1) AR043624A1 (enExample)
AT (1) ATE468323T1 (enExample)
AU (1) AU2004222139B2 (enExample)
CA (1) CA2519209C (enExample)
CY (1) CY1110722T1 (enExample)
DE (2) DE10311763A1 (enExample)
DK (1) DK1606246T3 (enExample)
ES (1) ES2346215T3 (enExample)
IL (1) IL170934A (enExample)
MX (1) MXPA05009764A (enExample)
PL (1) PL1606246T3 (enExample)
PT (1) PT1606246E (enExample)
RU (1) RU2330838C2 (enExample)
SI (1) SI1606246T1 (enExample)
TW (1) TW200503995A (enExample)
WO (1) WO2004083165A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009147624A2 (en) * 2008-06-05 2009-12-10 Alembic Limited A process for preparing teriflunomide
CA2861411A1 (en) * 2012-01-28 2013-08-01 Optmed, Inc. Improved methylidene malonate process
CN104995166A (zh) * 2013-01-29 2015-10-21 Opt迈德有限公司 改进的1,1-二取代的乙烯方法
CN104693070A (zh) * 2013-12-10 2015-06-10 深圳翰宇药业股份有限公司 一种特立氟胺的合成方法
CN105272882B (zh) * 2014-07-23 2019-05-31 欣凯医药化工中间体（上海）有限公司 一种环保简便制备泰瑞米特的方法
CN116924937A (zh) * 2022-04-02 2023-10-24 江苏康缘药业股份有限公司 2-氰基-3-羟基-2-丁烯-(4-三氟甲基-苯基)酰胺制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
DE19636974A1 (de) * 1996-09-12 1998-03-19 Hoechst Ag 2-Cyano-3,5-dihydroxy-hex-2-en- carbonsäureamidderivate
WO2002034251A1 (en) * 2000-10-20 2002-05-02 Parker Hughes Institute Treatment of asthma with lfm analogues

Also Published As

Publication number Publication date
PL1606246T3 (pl) 2010-10-29
TW200503995A (en) 2005-02-01
AR043624A1 (es) 2005-08-03
MXPA05009764A (es) 2005-10-26
ES2346215T3 (es) 2010-10-13
WO2004083165A1 (de) 2004-09-30
EP1606246B1 (de) 2010-05-19
CA2519209C (en) 2011-12-06
CA2519209A1 (en) 2004-09-30
RU2330838C2 (ru) 2008-08-10
KR20050120647A (ko) 2005-12-22
JP2006520345A (ja) 2006-09-07
DE502004011176D1 (de) 2010-07-01
DE10311763A1 (de) 2004-10-07
KR101072237B1 (ko) 2011-10-12
CN1756737A (zh) 2006-04-05
HK1086818A1 (zh) 2006-09-29
IL170934A (en) 2009-11-18
RU2005132162A (ru) 2006-02-10
AU2004222139A1 (en) 2004-09-30
EP1606246A1 (de) 2005-12-21
AU2004222139B2 (en) 2010-03-04
JP4546952B2 (ja) 2010-09-22
ATE468323T1 (de) 2010-06-15
DK1606246T3 (da) 2010-09-06
CY1110722T1 (el) 2015-06-10
CN100361967C (zh) 2008-01-16
PT1606246E (pt) 2010-07-21

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