IL170934A - Method for producing 2-cyan-3-hydroxy-n-(phenyl)but-2-ene amides - Google Patents

Method for producing 2-cyan-3-hydroxy-n-(phenyl)but-2-ene amides

Info

Publication number
IL170934A
IL170934A IL170934A IL17093405A IL170934A IL 170934 A IL170934 A IL 170934A IL 170934 A IL170934 A IL 170934A IL 17093405 A IL17093405 A IL 17093405A IL 170934 A IL170934 A IL 170934A
Authority
IL
Israel
Prior art keywords
compound
formula
phenyl
mol
acid
Prior art date
Application number
IL170934A
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of IL170934A publication Critical patent/IL170934A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/26—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton

Description

METHOD FOR PRODUCING 2-CYAN-3-HYDROXY-N- (PHENYL)BUT-2-ENE AMIDES ta )3 -') -2-?i-i( 3£))-N-t7p iT n-3-iN^-2 n? \y Pearl Cohen Zedek Latzer P-8143-IL Method for producing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides Description The invention relates to a process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides from 2-cyano-N-(phenyl)acetamide, in particular the preparation of 2-cyano-3-hydroxy-N-[(4-trifluoromethyl)phenyl]but-2-enamide from 2-cyano-N-(4-trifluoromethylphenyl)acetamide.
The compound 2-cyano-3-hydroxy-N-[(4-trifluoromethyl)phenyl]but-2-enamide is known (US 5,679,709). Processes for preparing 2-cyano-3-hydroxy-N-[(4-trifluoromethyl)phenyl]but-2-enamide are described, for example, in US 5,519,042 or US 5,700,822. Disadvantages of the known processes are a low yield and a low purity.
It has now been found that 2-cyano-3-hydroxy-N-[phenyl]but-2-enamides can be prepared from 2-cyano-N-(phenyl)acetamide in the presence of acetic anhydride and sodium hydroxide.
The invention therefore relates to a process for producing the compound of formula I where R1 is a) -CF3, b) -O-CF3, c) -S-CF3, d) -OH, e) -NO2, f) halogen, g) benzyl h) phenyl, i) -O-phenyl, k) -CN, I) -O-phenyl, monosubstituted or polysubstituted with 1 ) -(Ci -C4)-alkyl, 2) halogen, 3) -O-CF3 or 4) -O-CH3, and R2 is a) -(Ci -C4)-alkyl, b) halogen or c) a hydrogen atom, which comprises reacting a compound of the formula II, where R1 and R2 are as defined above, in the presence of at least one base, acetic anhydride and at least one solvent and then isolating the resulting compound of the formula I.
The invention further relates to a process for producing the compound of the formula III wherein a compound of the formula IV is reacted in the presence of water, sodium hydroxide, acetic anhydride and an additional solvent and then the resultant compound of the formula III is isolated.
In the preparation of the compound of the formula I, a procedure is followed in such a manner that, first, the compound of the formula II or (2-cyano-N-(4-trifluoromethylphenyl)acetamide) is placed in a solvent and the resultant solution or suspension is cooled. Aqueous sodium hydroxide and acetic anhydride are then added, and the resultant reaction mixture is then stirred or shaken with cooling.
After an appropriate reaction time, the compound of the formula I is precipitated out using an acid. The compound of the formula I is isolated, for example, by crystallization or extraction, for example using ethyl acetate or toluene. Crystallization is promoted by cooling the suspension or further evaporation of the solvents.
The term "solvents" is taken to mean, for example, water, organic solvents for example: ketone solvents, such as acetone, methyl ethyl ketone or methyl isobutyl ketone; halogenated hydrocarbons such as dichloromethane; alcohols such as ethanol, isopropanol or n-butanol; ethers such as diisopropyl ether, diethoxymethane, or diethylene glycol dimethyl ether, hydrocarbons such as toluene; esters such as ethyl acetate; aprotic solvents such as dimethylformamide, dimethylacetamide, dimethyl sulfoxide or N-methylpyrrolidone or mixtures of said solvents, or phase-transfer catalysts such as quaternary ammonium or phosphonium salts, for example dimethylditetradecylammonium bromide, benzyltriethyl-ammonium chloride, Alliquat® 336 (3-methyltrioctlylammonium chloride), tetrabutylammonium hydrogen sulfate, or tetrabutylphosphonium chloride; crown ethers or cryptands such as 18-crown-6 or cryptand 222 [= 4,7,13,16,21 ,24-HEXAOXA-1 ,10-DIAZABICYCLO-(8.8.8)HEXACOSANE], or polyethylene glycols can be used, which is particularly advantageous in the case of slightly water-miscible solvents such as toluene.
The term "bases" is taken to mean alkali metal hydroxides, for example sodium hydroxide or potassium hydroxide, caustic soda in solid form or in the form of lyes of differing concentrations, alkali metal hydrides and alkaline earth metal hydrides, for example sodium hydride, calcium hydride; amides, for example sodium amide; alkoxides, eg sodium methoxide, potassium tert-butoxide, organometallic compounds, for example n-butyllithium; or amines, for example diethylisopropylamine or mixtures of said organic bases. The water present in the lye is then included in the calculation in preparation of the reaction mixture.
The term "halogen" is taken to mean fluorine, chlorine, bromine and iodine. The term "-(Ci -C4)-alkyl" is taken to mean hydrocarbon radicals such as methyl, ethyl, propyl, n-butyl or isobutyl.
Suitable acids are, for example, hydrochloric acid, sulfuric acid, nitric acid or phosphoric acid, or mixtures of the acids.
Preferably, for the inventive reaction, 150 mol to 300 mol of acetic anhydride and 100 mol to 550 mol of sodium hydroxide are used per 100 mol of the compound of the formula II or IV.
The amount of solvent used is generally from 3 kg to 1 1 kg per kg of the compound of the formulae II or IV, preferably from 4 kg to 6 kg.
The reaction time is generally between a few minutes and 24 hours, preferably 1 to 3 hours, depending on composition of the mixture and the temperature range selected.
The reaction temperature is from -5°C to 50°C, preferably from 0°C to 30°C, in particular 10°C.
The residual content of starting substrate of the compound of the formula II or 2-cyano-N-(4-trifluoromethylphenyl)acetamide was reduced below a content of 0.5% in the isolated 2-cyano-3-hydroxy-N-[(4-trifluoromethyl)-phenyl]but-2-enamide.
The starting substance for the inventive reaction can be prepared according to methods known from the literature, for example DE 1 900 947.
The process product is biologically active and is suitable, for example, for treating rheumatoid arthritis or multiple sclerosis.
Advantageous features in the inventive process are the very short reaction times, the omission of additional purification steps, the high yields and the high purity of the product prepared. Advantages of the inventive process are the essentially complete reaction to give the compound of the formula I or 2-cyano-3-hydroxy-N-[(4-trifluoromethyl)phenyl]but-2-enamide and a total byproduct content of less than 1 %.
Example 1 Preparation of 2-cyano-3-hydroxy-N-[(4-trifluoromethyl)phenyl]but-2-enamide 2.5 g of 2-cyano-N-(4-trifluoromethylphenyl)acetamide and 0.127 g of dimethylditetradecylammonium bromide were weighed into a Teflon reactor equipped with a frit. The reactor was blanketed with argon and charged with 15 ml of diethoxymethane. The shaking was turned on and the contents were cooled to 15°C. 1 .73 ml of aqueous 50% strength NaOH were added manually and, in the course of 5 to 20 min, a total of 2.12 ml of acetic anhydride were added. Then the reaction mixture was monitored by HPLC repeatedly. The suspension was shaken for a further 8.5 hours (h) after addition of acetic anhydride.
Thereafter, the reactor was cooled to 5°C. In the course of 10 (minutes) min, 3.20 ml of water and 2.90 ml of HCI, 37% were each added, the reactor internal temperature being kept at 5°C. At this temperature the contents were shaken for 1 h. Subsequently, 13.0 ml of water were added to each reactor, warmed to 10°C and shaken for 1 h. The white suspension was ejected with argon. The remaining solids were washed three times each time with 15.0 ml of water, dried at 45°C and 150 mbar to constant weight, weighed and analyzed by HPLC.
HPLC method for 2-cyano-3-hydroxy-N-[(4-trifluoromethyl)phenyl]but-2-enamide Test technique: Liquid chromatography (European Pharmacopoeia) Apparatus: Liquid chromatograph: Alliance Separations Module Column: Material: stainless steel Length: 100 mm Internal diameter: 4.6 mm Stationary phase: Waters Symmetry-C18 Particle size 3.5 /vm Mobile phase: Acetonitrile: 350 ml Water: 650 ml Triethylamine: 5 ml adjust to pH 6.0 using H3P04 85% Injection volume: 10 /vl Sample applicator 12°C temperature: Column temperature: 20°C Flow rate: 0.8 ml/min Run time: 45 min Detection: UV/Vis, 210 nm Standard solution: 14.0 mg of reference standard are sonicated in 2 ml of acetonitrile and made up to 20 ml.
Test solution: 12.5 mg of substance are dissolved with acetonitrile R to give 25 ml.
Retention times (min): absolute relative 2-Cyano-3-hydroxy-N-[(4-trifluoromethyl)- 6.4 ± 10% 1 .0 phenyl]but-2-enamide: 2-Cyano-N-(4-trifluoromethylphenyl)- 12.8 ± 10% 2.0 ± 10% acetamide: 4-Trifluoromethylaniline: 14.1 ± 10% 2.2 ± 10% ^ , , t. AB -100 a/ . , , Calculation: — ■= = % byproduct AB = peak area of the respective byproduct in the chromatogram of the test solution ∑A = sum of all peak areas in the chromatogram of the test solution except for the injection peak Examples 2 to 7 The experiments in Table 1 were carried out in a similar manner to Example 1 Table 1 : Various solvent mixtures Molar Volum Yield Exampl equivalent PTC(1) Solvent e [% of e s [ml] theory] PTC Dimethylditetradec 2 ylammonium Toluene 30 0.1 48.3 bromide Dimethylditetradec 3 ylammonium Toluene 30 0.05 53.6 bromide Dimethylditetradec Diethoxy 4 ylammonium 25 0.1 65.4 methane bromide Benzyltriethyl Diethoxy ammonium 30 0.05 73.7 methane chloride Dimethylditetradec Diethoxy 6 ylammonium 30 0.05 79.4 methane bromide Benzyltriethyl Diethoxy 7 ammonium 15 0.1 77.8 methane chloride PTC means phase-transfer catalyst Example 8: 2.5 g of 2-cyano-N-(4-trifluoromethylphenyl)acetamide and 15 ml of acetone were charged into a Teflon reactor equipped with a frit. The shaking was turned on and the mixture was cooled to 15°C. 1 .73 ml of aqueous 50% strength NaOH were added by hand and 2.12 ml of acetic anhydride were added in the course of 5 to 20 min, with sampling and HPLC monitoring being carried out repeatedly. After the acetic anhydride had been added, the suspension was shaken for a further 8.5 h and cooled to 5°C. In the course of 10 min, 3.20 ml of water and 2.90 ml of HCI, 37%, were each added, with the reactor internal temperature being kept at 5°C. At this temperature, the contents were shaken for 1 h. Subsequently 13.0 ml of water were added, the mixture was warmed to 10°C and shaken for 1 h. The white suspensions were ejected with argon. The residual solids were washed 3 times, each time with 15.0 ml of deionized water, dried to constant weight at 45°C and 150 mbar, weighed and analyzed by HPLC. Yield 2.76 g (92% of theory, HPLC purity 98.3) Example 9: 9.1 g of 2-cyano-N-(4-trifluoromethylphenyl)acetamide were weighed into a 200 ml four-neck flask and then suspended adding 49 ml of methyl isobutyl ketone (slightly yellow low-viscosity suspension), which was then cooled to 10°C. At this temperature, 17.8 ml of 33% strength NaOH were added directly from the measuring cylinder. In the course of this the temperature increased to 12°C and a creamy-colored suspension which was difficult to stir was formed. This was stirred vigorously for 10 min. Thereafter, in the course of 1 h and 20 min, 9.7 ml of acetic anhydride are added dropwise at 7 to 12°C. In the course of this the viscous suspension was converted into a slightly turbid orange solution from which, after 50 min of dropwise addition (about 7 ml added dropwise) a solid crystallized out, as a result of which a spontaneous temperature increase was observed (maximum above 12°C). After sampling and HPLC analysis, about 1.29% peak area of the starting substance 2-cyano-N-(4-trifluoromethylphenyl)acetamide was still found in the reaction mixture. The dropwise addition was not interrupted. At the end of the dropwise addition after 1 h and 20 min, according to HPLC analysis, complete conversion had been achieved (about 0.13% peak area of 2-cyano-N-(4-trifluoromethylphenyl)acetamide). The mixture was stirred for a further 50 min, being cooled to 3 to 5°C.
Then, at this temperature, 1 1 .5 ml of water were added dropwise in the course of 10 min; the mixture had a pH of 7.1 . 16 ml of 37% strength HCI were then added dropwise in the course of 1 h, so that, at a constant temperature, a pH of 1 .1 was reached. After further stirring for 25 min, the pH was still 1 .1 (creamy-colored non-homogeneous stirrable suspension, as soon as after about 7 ml of HCI). Within the next 20 min, 47.5 ml of water were added dropwise, the temperature increasing to 10°C. The pH increased to 1 .7. The mixture was then further stirred for 40 min. Thereafter the suspension was removed by suction and the residue was washed chloride-free 5 times with 30 ml of water. A creamy-colored solid was obtained which was dried under reduced pressure at 40°C.
Yield: 9.8 g (91 % of theory, HPLC purity 99.0) The reactions according to Table 2 were carried out in a similar manner to Examples 8 and 9.
Table 2 * 30% strength NaOH ** 33% strength NaOH

Claims (4)

10 170934/2 CLAIMS
1. A process for producing the compound of the formula I where R1 is a) — CF3, b) -O-CFs, c) -S-CF3, d) -OH, e) -NO2, f) halogen, g) benzyl h) phenyl, i) — O-phenyl, k) — CN, I) — O-phenyl, monosubstituted or polysubstituted with 1) (C C4)-alkyl,
2. ) halogen,
3. ) — O— CF3or
4. ) — O— CH3, and R2 is a) (C C4)-alkyl, b) halogen or c) a hydrogen atom, which comprises reacting a compound of the formula II, 1 1 170934/2 where R1 and R2 are as defined above, in the presence of at least one base, acetic anhydride and at least one solvent and then isolating the resulting compound of the formula I. The process as claimed in claim 1 , wherein a compound of the formula III is prepared from a compound of the formula IV and the resulting compound of the formula III is then isolated. The process as claimed in claim 1 or 2, wherein the base used is selected from the group consisting of alkali metal hydroxides, caustic soda, alkali metal hydrides, alkaline earth metal hydrides, amides, alkoxides, organometallic compounds, amines and mixtures thereof. 12 170934/2 The process as claimed in claim 1 or 2, wherein the solvent used is selected from the group consisting of water; organic solvents selected from the group consisting of ketone solvents, halogenated hydrocarbons, alcohols, ethers, hydrocarbons, esters, aprotic solvents and mixtures thereof; phase-transfer catalysts; crown ethers; cryptands; polyethylene glycols; and mixtures thereof. The process as claimed in claim 1 or 2, wherein the compound of the formula I or III is precipitated out using an acid. The process as claimed in claim 5, wherein the acid is selected from the group consisting of hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid and mixtures thereof. The process as claimed in claim 1 or 2, wherein from 150 mol to 300 mol of acetic anhydride and from 100 mol to 550 mol of sodium hydroxide are used per 100 mol of the compound of the formulae II or IV. The process as claimed in claim 1 or 2, wherein the solvent is used in an amount of from 3 kg to 1 1 kg, based on 1 kg of the compound of the formula II or IV. The process as claimed in claim 1 or 2, wherein the reaction temperature is from
IL170934A 2003-03-18 2005-09-18 Method for producing 2-cyan-3-hydroxy-n-(phenyl)but-2-ene amides IL170934A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10311763A DE10311763A1 (en) 2003-03-18 2003-03-18 Process for the preparation of 2-cyano-3-hydroxy-N- (phenyl) but-2-enamides
PCT/EP2004/002311 WO2004083165A1 (en) 2003-03-18 2004-03-06 Method for producing 2-cyan-3-hydroxy-n-(phenyl)but-2-ene amides

Publications (1)

Publication Number Publication Date
IL170934A true IL170934A (en) 2009-11-18

Family

ID=32945937

Family Applications (1)

Application Number Title Priority Date Filing Date
IL170934A IL170934A (en) 2003-03-18 2005-09-18 Method for producing 2-cyan-3-hydroxy-n-(phenyl)but-2-ene amides

Country Status (21)

Country Link
EP (1) EP1606246B1 (en)
JP (1) JP4546952B2 (en)
KR (1) KR101072237B1 (en)
CN (1) CN100361967C (en)
AR (1) AR043624A1 (en)
AT (1) ATE468323T1 (en)
AU (1) AU2004222139B2 (en)
CA (1) CA2519209C (en)
CY (1) CY1110722T1 (en)
DE (2) DE10311763A1 (en)
DK (1) DK1606246T3 (en)
ES (1) ES2346215T3 (en)
HK (1) HK1086818A1 (en)
IL (1) IL170934A (en)
MX (1) MXPA05009764A (en)
PL (1) PL1606246T3 (en)
PT (1) PT1606246E (en)
RU (1) RU2330838C2 (en)
SI (1) SI1606246T1 (en)
TW (1) TW200503995A (en)
WO (1) WO2004083165A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280938A4 (en) 2008-06-05 2013-01-23 Alembic Pharmaceuticals Ltd A process for preparing teriflunomide
US20130197263A1 (en) 2012-01-28 2013-08-01 Optmed, Inc. 1,1-disubstituted ethylene process
CN104995166A (en) * 2013-01-29 2015-10-21 Opt迈德有限公司 Improved 1, 1-disubstituted ethylene process
CN104693070A (en) * 2013-12-10 2015-06-10 深圳翰宇药业股份有限公司 Method for synthesizing teriflunomide
CN105272882B (en) * 2014-07-23 2019-05-31 欣凯医药化工中间体（上海）有限公司 A kind of easy method for preparing Tai Rui meter Te of environmental protection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
DE19636974A1 (en) * 1996-09-12 1998-03-19 Hoechst Ag 2-cyano-3,5-dihydroxy-hex-2-ene carboxamide derivatives
AU2001236361A1 (en) * 2000-10-20 2002-05-06 Parker Hughes Institute Treatment of asthma with lfm analogues

Also Published As

Publication number Publication date
DK1606246T3 (en) 2010-09-06
RU2330838C2 (en) 2008-08-10
JP4546952B2 (en) 2010-09-22
AR043624A1 (en) 2005-08-03
HK1086818A1 (en) 2006-09-29
DE10311763A1 (en) 2004-10-07
AU2004222139A1 (en) 2004-09-30
WO2004083165A1 (en) 2004-09-30
CY1110722T1 (en) 2015-06-10
MXPA05009764A (en) 2005-10-26
CN1756737A (en) 2006-04-05
EP1606246A1 (en) 2005-12-21
AU2004222139B2 (en) 2010-03-04
PL1606246T3 (en) 2010-10-29
RU2005132162A (en) 2006-02-10
DE502004011176D1 (en) 2010-07-01
KR101072237B1 (en) 2011-10-12
ATE468323T1 (en) 2010-06-15
PT1606246E (en) 2010-07-21
JP2006520345A (en) 2006-09-07
SI1606246T1 (en) 2010-08-31
TW200503995A (en) 2005-02-01
KR20050120647A (en) 2005-12-22
EP1606246B1 (en) 2010-05-19
CN100361967C (en) 2008-01-16
ES2346215T3 (en) 2010-10-13
CA2519209C (en) 2011-12-06
CA2519209A1 (en) 2004-09-30

Similar Documents

Publication Publication Date Title
RU2697581C1 (en) Fluoridation of esters of acrylic acid and derivatives thereof
US7803942B2 (en) Crystals of morphinan derivative and process for producing the same
IL170934A (en) Method for producing 2-cyan-3-hydroxy-n-(phenyl)but-2-ene amides
CN102875537A (en) Novel preparation method of antithrombosis medicine
US10927095B2 (en) Processes for the preparation of Niraparib and intermediates thereof
CN107118215B (en) A kind of preparation method for treating breast cancer medicines Rui Boxini intermediate
US6894184B2 (en) Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides
CA3230330A1 (en) Process for preparing {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate having high purity
EP3006449B1 (en) Method for synthesizing optically active alpha-amino acid using chiral metal complex comprising axially chiral n-(2-acylaryl)-2-[5,7-dihydro-6h-dibenzo[c,e]azepin-6-yl]acetamide compound and amino acid
Gerus et al. Uncommon fluorination of enones with xenon difluoride
TW201831441A (en) Process for the one-pot preparation of organo-iodized compounds
JP2006265129A (en) Method for producing 3,3'-bis(trifluoromethyl)hydrazobenzene
WO2005066117A1 (en) Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
US7141693B2 (en) Process for producing β-oxonitrile compound or alkali metal salt thereof
KR101184915B1 (en) Process for preparing high-purity prasugrel
CN113816955B (en) RET kinase inhibitor intermediate and preparation method thereof
JP5309680B2 (en) Method for producing fluorinated ester compound and intermediate thereof
JP5032732B2 (en) Synthesis of chlorinated pyrimidines.
WO2001040161A1 (en) The preparation of 4,4'-dinitrodiphenylamine from urea and nitrobenzene
JP2001510178A (en) Method for producing 3-hydroxy-2-methylbenzoic acid
WO2023058050A1 (en) A process for preparation of pharmaceutically active compounds via selective nitro reduction reactions
RU2315749C1 (en) Method for preparing 2,4,6-trichloro-3,5-dinitroaniline
JP2003113151A (en) N-unsubstituted amidinium salt
CN109665982A (en) The synthetic method of Nefiracetam intermediate 2-Pyrrolidone
JPS63165354A (en) Production of asymmetric cyanhydrin

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed