KR101060539B1 - Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 - Google Patents

Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 Download PDF

Info

Publication number
KR101060539B1
KR101060539B1 KR1020087021067A KR20087021067A KR101060539B1 KR 101060539 B1 KR101060539 B1 KR 101060539B1 KR 1020087021067 A KR1020087021067 A KR 1020087021067A KR 20087021067 A KR20087021067 A KR 20087021067A KR 101060539 B1 KR101060539 B1 KR 101060539B1
Authority
KR
South Korea
Prior art keywords
carboxylic acid
thiazole
formula
phenyl
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087021067A
Other languages
English (en)
Korean (ko)
Other versions
KR20080090550A (ko
Inventor
존 프레데릭 보일랜
?컸? 차이
나데 포뚜이
폴 길레스피
주니어 로버트 앨런 굿나우
캉 르
크리스토프 미슈
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20080090550A publication Critical patent/KR20080090550A/ko
Application granted granted Critical
Publication of KR101060539B1 publication Critical patent/KR101060539B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1020087021067A 2006-02-27 2007-02-19 Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 Expired - Fee Related KR101060539B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27
US60/776,964 2006-02-27
PCT/EP2007/051541 WO2007096315A1 (en) 2006-02-27 2007-02-19 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as plk1 inhibitors

Publications (2)

Publication Number Publication Date
KR20080090550A KR20080090550A (ko) 2008-10-08
KR101060539B1 true KR101060539B1 (ko) 2011-08-30

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087021067A Expired - Fee Related KR101060539B1 (ko) 2006-02-27 2007-02-19 Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드

Country Status (19)

Country Link
US (1) US7504513B2 (https=)
EP (1) EP1991543A1 (https=)
JP (1) JP2009528284A (https=)
KR (1) KR101060539B1 (https=)
CN (1) CN101415704A (https=)
AR (1) AR059621A1 (https=)
AU (1) AU2007217575A1 (https=)
BR (1) BRPI0710473A2 (https=)
CA (1) CA2642921A1 (https=)
CR (1) CR10206A (https=)
EC (1) ECSP088700A (https=)
IL (1) IL193481A0 (https=)
MA (1) MA30260B1 (https=)
MX (1) MX2008010884A (https=)
NO (1) NO20083708L (https=)
RU (1) RU2008138163A (https=)
TW (1) TW200745097A (https=)
WO (1) WO2007096315A1 (https=)
ZA (1) ZA200807074B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008149784A1 (ja) * 2007-06-08 2008-12-11 Nec Corporation 半導体集積回路及びフィルタ制御方法
US9029411B2 (en) 2008-01-25 2015-05-12 Millennium Pharmaceuticals, Inc. Thiophenes and uses thereof
US8962614B2 (en) * 2008-04-17 2015-02-24 The Johns Hopkins University ON01910.Na enhances chemotherapeutic agent activity in drug-resistant tumors
WO2010029327A1 (en) * 2008-09-10 2010-03-18 Datalase Ltd. Data storage medium
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
WO2010121675A2 (en) * 2008-12-18 2010-10-28 F. Hoffmann-La Roche Ag Thiazolyl-benzimidazoles
WO2010090716A1 (en) 2009-01-30 2010-08-12 Millennium Pharmaceuticals, Inc. Heteroaryls and their use as pi3k inhibitors
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
TW201217365A (en) 2010-08-11 2012-05-01 Millennium Pharm Inc Heteroaryls and uses thereof
WO2012021611A1 (en) 2010-08-11 2012-02-16 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US8859768B2 (en) 2010-08-11 2014-10-14 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
TW201307309A (zh) 2010-10-13 2013-02-16 Millennium Pharm Inc 雜芳基化合物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
DK1320531T3 (da) 2000-08-10 2011-01-03 Pfizer Italia Srl Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
CA2515243A1 (en) 2002-02-22 2003-08-28 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
US7183276B2 (en) * 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
WO2003072062A2 (en) 2002-02-28 2003-09-04 Temple University-Of The Commonwealth System Of Higher Education Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
US20060079503A1 (en) 2002-05-03 2006-04-13 Schering Aktiengesellschaft Thiazolidinones and the use therof as polo-like kinase inhibitors
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
BR0313160A (pt) * 2002-08-08 2005-07-12 Smithkline Beecham Corp Composto, composição farmacêutica, métodos para tratar uma condição e um neoplasmo suscetìvel em um animal em um animal, processo para preparar um composto e uso de um composto
US20050196808A1 (en) 2002-11-14 2005-09-08 Yaffe Michael B. Products and processes for modulating peptide-peptide binding domain interactions
AU2003284399A1 (en) 2002-11-14 2004-06-03 Kyowa Hakko Kogyo Co., Ltd. Plk inhibitors
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
ES2325440T3 (es) 2003-02-20 2009-09-04 Smithkline Beecham Corporation Compuestos de pirimidina.
JP2006522127A (ja) 2003-04-01 2006-09-28 スミスクライン ビーチャム コーポレーション イミダゾトリアジン化合物
EP1641780B1 (en) 2003-06-24 2008-11-12 Pfizer Products Incorporated Processes for the preparation of 1- [(benzoimidazole-1yl) quinolin-8-yl] piperidin-4-ylamine derivatives
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
JP5164380B2 (ja) 2003-10-21 2013-03-21 サイクラセル リミテッド ピリミジン−４−イル−３，４−チオン化合物及び治療におけるその使用
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

Also Published As

Publication number Publication date
BRPI0710473A2 (pt) 2011-08-16
ECSP088700A (es) 2008-09-29
CR10206A (es) 2008-09-22
US7504513B2 (en) 2009-03-17
IL193481A0 (en) 2009-05-04
AU2007217575A1 (en) 2007-08-30
TW200745097A (en) 2007-12-16
MA30260B1 (fr) 2009-03-02
US20070203210A1 (en) 2007-08-30
ZA200807074B (en) 2009-10-28
NO20083708L (no) 2008-09-23
RU2008138163A (ru) 2010-04-10
EP1991543A1 (en) 2008-11-19
AR059621A1 (es) 2008-04-16
CN101415704A (zh) 2009-04-22
MX2008010884A (es) 2008-09-03
JP2009528284A (ja) 2009-08-06
WO2007096315A1 (en) 2007-08-30
KR20080090550A (ko) 2008-10-08
CA2642921A1 (en) 2007-08-30

Similar Documents

Publication Publication Date Title
KR101060539B1 (ko) Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드
EP2493862B1 (en) Imidazole derivatives as ido inhibitors
JP4805916B2 (ja) 化合物、組成物、および方法
AU2008253684B2 (en) Pyrimidinones as Casein kinase II (CK2) modulators
US8318928B2 (en) Fused imidazole carboxamides as TRPV3 modulators
CN104003940B (zh) 2,4‑二氟‑5‑(酞嗪酮‑1‑甲基)‑苯甲酰哌嗪类化合物及其用途
CA2985542A1 (en) Triazole agonists of the apj receptor
CA2711603A1 (en) Activators of executioner procaspases 3, 6 and 7
JP2002537298A (ja) ピリジン化合物およびその医薬用途
Jin et al. 4-([1, 2, 4] Triazolo [1, 5-a] pyridin-6-yl)-5 (3)-(6-methylpyridin-2-yl) imidazole and-pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type I receptor kinase
US7803825B2 (en) Aminoalkylazole derivatives as histamine-3 antagonists
JP7266901B2 (ja) 複素環式化合物、調製方法及びその医薬的な応用
RS59787B1 (sr) Novo heterociklično jedinjenje, metoda za pripremu istog, i farmaceutska kompozicija koja sadrži isto
AU2020264679B2 (en) Selective ligands of human constitutive androstane receptor
US20240217969A1 (en) Substituted pyrrole carboxamides, process for their preparation and their use as kinase inhibitors
JP2009514865A (ja) 有糸分裂キネシン阻害剤
CZ34975U1 (cs) Ligandy lidského konstitutivního adrostanového receptoru
HK1133012B (en) Pyrimidinones as casein kinase ii (ck2) modulators

Legal Events

Date Code Title Description
A201 Request for examination
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20140825

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20140825

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000