KR101035931B1 - 2-페닐벤조티아졸린 유도체로 이루어진 κ 오피오이드 수용체 작용약 - Google Patents

2-페닐벤조티아졸린 유도체로 이루어진 κ 오피오이드 수용체 작용약 Download PDF

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Publication number
KR101035931B1
KR101035931B1 KR1020047015318A KR20047015318A KR101035931B1 KR 101035931 B1 KR101035931 B1 KR 101035931B1 KR 1020047015318 A KR1020047015318 A KR 1020047015318A KR 20047015318 A KR20047015318 A KR 20047015318A KR 101035931 B1 KR101035931 B1 KR 101035931B1
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South Korea
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group
acetyl
methoxyphenyl
propoxy
chloro
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KR1020047015318A
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English (en)
Korean (ko)
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KR20040095329A (ko
Inventor
도카이마키
혼다다카히로
니와마사시
오스미야에코
후지무라켄-이치
고노신-이치
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산텐 세이야꾸 가부시키가이샤
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Publication of KR20040095329A publication Critical patent/KR20040095329A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
KR1020047015318A 2002-03-29 2003-03-28 2-페닐벤조티아졸린 유도체로 이루어진 κ 오피오이드 수용체 작용약 KR101035931B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2002-00097500 2002-03-29
JP2002097500 2002-03-29
PCT/JP2003/003928 WO2003082840A1 (en) 2002-03-29 2003-03-28 κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE

Publications (2)

Publication Number Publication Date
KR20040095329A KR20040095329A (ko) 2004-11-12
KR101035931B1 true KR101035931B1 (ko) 2011-05-23

Family

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Family Applications (1)

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KR1020047015318A KR101035931B1 (ko) 2002-03-29 2003-03-28 2-페닐벤조티아졸린 유도체로 이루어진 κ 오피오이드 수용체 작용약

Country Status (10)

Country Link
US (2) US7112598B2 (US20060205796A1-20060914-C00073.png)
EP (2) EP1496053B1 (US20060205796A1-20060914-C00073.png)
JP (1) JP5061134B2 (US20060205796A1-20060914-C00073.png)
KR (1) KR101035931B1 (US20060205796A1-20060914-C00073.png)
CN (2) CN100522954C (US20060205796A1-20060914-C00073.png)
AU (2) AU2003220894B8 (US20060205796A1-20060914-C00073.png)
CA (1) CA2480560C (US20060205796A1-20060914-C00073.png)
ES (1) ES2390052T3 (US20060205796A1-20060914-C00073.png)
NZ (1) NZ535987A (US20060205796A1-20060914-C00073.png)
WO (1) WO2003082840A1 (US20060205796A1-20060914-C00073.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1642590A4 (en) * 2003-07-04 2009-05-13 Santen Pharmaceutical Co Ltd MEANS TO INHIBIT THE DEGRADATION OF THE PAIN LIMIT
US7642274B2 (en) 2004-07-02 2010-01-05 Santen Pharmaceutical Co., Ltd. Inhibitor of pain threshold decrease
EP1849465A4 (en) * 2005-02-18 2008-12-24 Takeda Pharmaceutical AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR
US9303027B2 (en) 2010-07-19 2016-04-05 Dr. Reddy's Laboratories Ltd. Kappa opioid receptor agonists
CN104271552B (zh) 2012-03-05 2017-08-08 雷迪博士实验室有限公司 作为kappa阿片样物质受体(kor)激动剂的取代的杂环乙酰胺
JP6275517B2 (ja) 2013-03-22 2018-02-07 あゆみ製薬株式会社 Ｉｌ−２産生抑制
WO2015093567A1 (ja) 2013-12-18 2015-06-25 国立大学法人京都大学 疼痛に関する化合物及び医薬組成物
WO2018230711A1 (ja) 2017-06-16 2018-12-20 学校法人同志社 ｍＴＯＲインヒビターを含む、眼の症状、障害または疾患を治療または予防するための医薬およびその応用
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US547513A (en) * 1895-10-08 Chell
US4479949A (en) * 1981-09-12 1984-10-30 Santen Pharmaceutical Co., Ltd. Benzothiazoline compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4994667A (US20060205796A1-20060914-C00073.png) * 1973-01-23 1974-09-09
JPS5967276A (ja) 1982-09-01 1984-04-16 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体
JPS60139679A (ja) 1983-12-27 1985-07-24 Santen Pharmaceut Co Ltd ２−アリ−ルベンゾチアゾリン誘導体
JPS6183175A (ja) * 1984-09-06 1986-04-26 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤
JPS62221679A (ja) 1986-03-19 1987-09-29 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体
JPH066581B2 (ja) * 1986-03-19 1994-01-26 参天製薬株式会社 フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体
JPH08231399A (ja) * 1995-02-23 1996-09-10 Shionogi & Co Ltd モルヒネ禁断抑制作用剤
US6174891B1 (en) * 1996-11-25 2001-01-16 Toray Industries, Inc. Antipruritic agent
JP2000344821A (ja) 1999-06-01 2000-12-12 Toagosei Co Ltd オレフィン重合用触媒

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US547513A (en) * 1895-10-08 Chell
US4479949A (en) * 1981-09-12 1984-10-30 Santen Pharmaceutical Co., Ltd. Benzothiazoline compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of medicinal chemistry, 1988, 31(5), 919-930
Journal of medicinal chemistry, 2000, 43, 3474-3477

Also Published As

Publication number Publication date
US7410987B2 (en) 2008-08-12
CN1642929A (zh) 2005-07-20
JP5061134B2 (ja) 2012-10-31
WO2003082840A1 (en) 2003-10-09
US20050113430A1 (en) 2005-05-26
CN100522954C (zh) 2009-08-05
EP1496053A1 (en) 2005-01-12
EP2042173A2 (en) 2009-04-01
ES2390052T3 (es) 2012-11-06
CN1911918A (zh) 2007-02-14
CN1642929B (zh) 2010-05-12
KR20040095329A (ko) 2004-11-12
NZ535987A (en) 2006-08-31
US7112598B2 (en) 2006-09-26
EP1496053B1 (en) 2012-06-20
AU2009201233B2 (en) 2012-07-05
CA2480560C (en) 2011-02-15
JP2009143940A (ja) 2009-07-02
AU2003220894B2 (en) 2009-02-05
EP2042173A3 (en) 2010-02-24
AU2003220894B8 (en) 2009-02-19
US20060205796A1 (en) 2006-09-14
CA2480560A1 (en) 2003-10-09
AU2009201233A1 (en) 2009-04-23
AU2003220894A1 (en) 2003-10-13
EP1496053A4 (en) 2008-01-16

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